Prestigious NY Cancer Center Will Spend $3.7M To Study Bogus Cancer Treatment – Forbes

Reportage in a Chinese medicine practice in Lyon, France Acupuncture session. (Photo by: ... [+] BSIP/Universal Images Group via Getty Images)

Sometimes I'm not sure whether the best response to pseudoscience is to ignore it, or to patiently try to explain why it's wrong, or to get mad.

This week I'm mad.

My anger and frustration was triggered bya tweetfrom Memorial Sloan-Kettering's Integrative Medicine account, shown here:

Image captured by the author

For those who don't know,Memorial Sloan-Kettering Cancer Centeris one of the world's leading cancer centers, both for treatment and research. If you are diagnosed with cancer, MSK is one of the best places to go.

But not everything at MSK is world class. Unfortunately, they have an"integrative medicine"center that offers a mixture of therapies ranging from helpful to benign to useless. One of their biggest activities is acupuncture, which they claim offers a wide range of benefits to cancer patients.

The MSK tweet shown here was boasting abouta new, $3.7 million studyfunded by NIH to study the effect of acupuncture on pain that cancer patients experience from chemotherapy and bone-marrow transplants.

Here's why I'm mad: cancer patients are extremely vulnerable, often suffering the most frightening and difficult experience of their lives. They are completely dependent on medical experts to help them. When a place like MSK suggests a treatment, patients take it very seriouslyas they should. But they really have no choice: a cancer patient cannot easily look for a second opinion, or switch hospitals or doctors. Even if they have the money (and cancer treatment is extremely expensive), switching hospitals might involve a long interruption with no treatment, during which they could die, and it might also involve traveling far from their home.

Offering these patients ineffective treatments based on pseudoscienceand make no mistake, that's what acupuncture isis immoral. Now, I strongly suspect that the MSK's "integrative medicine" doctors sincerely believe that acupuncture works. Their director, Jun Mao, is clearly a true believer, as explained inthis profile of himon the MSK website. But that doesn't make it okay.

I've written about acupuncture many times before (here,here,here, andhere, for example), but let me explain afresh why it is nonsense.

Acupuncture is based on a pre-scientific notion, invented long before humans understood physiology, chemistry, neurology, or even basic physics, which posits that a mysterious life force, called "qi," flows through the body on energy lines called meridians. As explainedin this article by MSK's Jun Mao:

"According to traditional Chinese medicine ... interruption or obstruction of qi was believed to make one vulnerable to illness. The insertion of needles at specific meridian acupoints was thought to regulate the flow of qi, thus producing therapeutic benefit."

Today we know that none of this exists. There is no qi, and there are no meridians. In that same article, Jun Mao continued by admitting that

"the ideas of qi and meridians are inconsistent with the modern understanding of human anatomy and physiology."

And yet this is what they offer to patients at MSK.

Just to be certain, I readone of the latest studies from MSK, published early this year, which claims to show that acupuncture relieves nausea, drowsiness, and lack of appetite in multiple myeloma patients who were going through stem cell transplants.

It's a mess: totally unconvincing, and a textbook case of p-hacking (ordata dredging). The paper describes a very small study, with just 60 patients total, in which they measured literally dozens of possible outcomes: overall symptom score at 3 different time points, a different score at 3 time points, each of 13 symptoms individually, and more. I counted 24 different p-values, most of them not even close to significant, but they fixated on the 3 that reached statistical significance. The two groups of 30 patients weren't properly balanced: the sham acupuncture group started out with more severe symptoms according to their own scoring metric, andFigure 2in the paper makes it pretty clear that there was no genuine difference in the effects of real versus sham acupuncture.

But they got it published (in a mediocre journal), so now they point to it as "proof" that acupuncture works for cancer patients. This study, bad as it is, appears to be the basis of the $3.7 million NIH grant that they're now going to use, they say, in "a larger study in 300 patients to confirm these previous findings."

And there you go: the goal of the new study,according to the scientists themselves, is not to see if the treatment works, but to confirm their pre-existing belief that acupuncture works. Or, asone scientist remarked on Twitter, "they already have a result in mind, the whole wording of this suggests that they EXPECT a positive outcome. How did this get funded exactly?"

Good question.

So I'm mad. I'm mad that NIH is spending millions of dollars on yet another study of a quack treatment (acupuncture) that should have been abandoned decades ago, but that persists because people make money off it. (And, as others have explained in detail, acupuncture is actually a huge scam that former Chinese dictator Mao Zedong foisted on his own people, because he couldn't afford to offer them real medicine. For a good expos of Chairman Mao's scam,see this 2013 Slate piece.)

But I'm even more upset that doctors at one of the world's leading cancer centers are telling desperately ill patients, who trust them with their lives, that sticking needles into their bodies at bogus "acupuncture points" will relieve the pain and nausea of chemotherapy, or help them with other symptoms of cancer. I'm willing to bet that most MSK doctors don't believe any of this, but they don't want to invest the time or energy to try to stop it.

(I am somewhat reassured by the fact that MSK'sTwitter accounthas nearly 75,000 followers, while it's integrative medicine Twitter account has just 110.)

Or perhaps they are "shruggies": doctors who don't believe in nonsense, but figure it's probably harmless so they don't really object. To them I suggest this:read Dr. Val Jones's accountof how she too was a shruggie, until she realized that pseudoscience causes real harm.

And finally, let me point tothis study inJAMA Oncologyfrom last year,by doctors from Yale, which looked at the use of so-called complementary therapies among cancer patients. They found that

"Patients who received complementary medicine were more likely to refuse other conventional cancer treatment, and had a higher risk of death than no complementary medicine."

And also seethis 2017 studyfrom the Journal of the National Cancer Institute, which found that patients who used alternative medicine were 2.5 times more likely to die than patients who stuck to modern medical treatments.

That's right,Memorial Sloan-Kettering: patients who use non-traditional therapies are twice as likely to die. Thats why Im mad. This is not okay.

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Prestigious NY Cancer Center Will Spend $3.7M To Study Bogus Cancer Treatment - Forbes

Breathe to Perform: Improve Your Breathing To Unlock Hidden Athletic Potential – BOXROX

If youre anything like me, the memory of your very first CrossFit WOD is burned into your lungs.

From the moment that the clock started running until the very last rep of the workout, you likely sucked wind harder than at any previous point in your life. As you fell to the ground afterwards in a heap of exhaustion, a love/hate relationship with the sport of fitness developed right on the chalk stained and sweat soaked spot.

What many of us were experiencing was an introduction to metabolic conditioning. This newly coined term describes a high intensity training model designed to, in the words of CrossFit founder Greg Glassman, increase the storage and delivery of energy for any activity.

In a 2003 Crossfit Journal article, Glassman shared his position on the importance of metabolic conditioning to avoid specificity of adaptation allowing for first wave cardiovascular and respiratory adaptations.

Its been 16 years since that original journal article was written.

16 years of thrusters, wall-balls and those ever elusive airdyne calories. 16 years of sweat, grit, commitment, and community. A lot of memories and training milestones can be packed into a 16 year time frame.

There are a lot of cardiovascular and respiratory adaptations that can be made as well. One of the greatest physiological adaptations that an athlete can make, however, remains largely untapped in the sports training community.This leaves the door to progress wide open, despite how seasoned and experienced a CrossFit athlete you may be. It is the adaptation that determines how the process of delivering energy for any activity that Glassman spoke about 16 years ago actually occurs.

Its our ability to utilise oxygen more efficiently and more effectively.

Understanding how oxygen is directly related to energy production may mark the next major paradigm shift in human health, fitness and sports performance.

When CrossFit first began, anaerobic output was a glaring weak link in the athletic chain for many athletes. The sport has evolved to the point where this statement might not be true anymore.

Past Games events have demonstrated the effectiveness of CrossFits ability to increase work capacity over short duration. High intensity workouts showcase a collective need to perform more aerobic capacity training.

But, what is aerobic capacity? Does it mean just putting in more LSD (long, slow distance) efforts or is it changing the way that our body utilises oxygen to fuel the release of ATP to power muscular activity.

It is possible to put in hours of focused endurance work each week while never making the critical adaptation which allows this process of more effective energy delivery to take place: that process is an increased tolerance to carbon dioxide and must be trained specifically in order to be improved.

Take the following test from the book The Oxygen Advantage by Patrick McKeown to determine whether your breathing is a buried weakness or a hidden strength.

Note: This is not a test of willpower or a test of how long you can hold your breath. Once you get the first urge to breathe stop the timer and you will have the information that you need to assess your C02 tolerance.

Was it 10 seconds? 20 seconds? 40 seconds or more?

If you were in a large room filled with athletes performing this test you would find that C02 scores would run the gamut from less than 10 seconds to more than 40 seconds.

What does your score mean, and how does it affect your athletic performance?

A score below 20 seconds indicates a comparatively high level of sensitivity to carbon dioxide which will require you to rely on a higher volume of oxygen during training while needing to offload more C02.

This is an athletic disadvantage when compared to an athlete who can work at higher intensities with an increased ability to utilise C02 for more efficient oxygen transport, instead of ridding the body of C02 prematurely and suffering the cost of gassing out as a result.

For every 5 second increase in your C02 tolerance score you can expect to feel more energy, increased stamina, and less fatigue in your aerobic training.

When you exhale and pinch your nose, carbon dioxide levels begin to rise. Your sensitivity to rising carbon dioxide will determine how you will need to breathe during a difficult workout which, in turn, determines your ability to use available oxygen to power those hard working muscles when you need it most.

I strongly believe that the ability to extract and utilisethese basic physiological principles will separate the pack in the seasons to come.

Although variance is a key tenet to the CrossFit training methodology, the WOD is written clearly on the board prior to each training session or competition along with the implicit energy system demands and estimated workout duration for all competitors to study.

A rudimentary understanding of energy consumption and energy demands allows each competitor to make basic decisions about pace prior to the workout beginning. Unlike a sport such as mixed martial arts where the energy demands may be directly dependant on the tactics and approach of your opponent, or a team sport such as basketball where a dynamic interplay between players dictates the pace of the game, CrossFit offers a strategic opportunity that is akin to understanding the basics of accounting.

Oxygen Is Currency. Movement is Expensive.

If you have a $1,000 budget for a 5 day vacation, you would be unlikely to spend $900 of it on the first day. Equally, if you saw a 21 minute workout on the whiteboard you would be unlikely to approach it as if it were a 400m sprint.

Understanding the aerobic and anaerobic demands of each workout beforehand allows you to approach each effort with a heightened level of athletic intelligence.

An understanding of how breathing impacts aerobic and anaerobic performance and that you can not only control your breathing but significantly improve it allows you to gain a competitive advantage in your next WOD despite the specific time demands of the workout.

Simple Breathing Techniques to Improve your Crossfit Performances

The process of cellular respiration is a complex one. Fortunately, even the most basic understanding of how oxygen fuels muscular activity can provide a distinct advantage in terms of pacing yourself during workouts as well as in the development of stronger breathing muscles and an increased tolerance to carbon dioxide: the secret ingredient when it comes to utilising oxygen effectively and efficiently.

The next time you find yourself bent over with hands-on-knees after a tough set of thrusters, struggling to get air into your lungs, keep the following in mind:

There is no shortage of available oxygen in the atmosphere.

It is your internal environment that has changed due to the intensity of the workout. More specifically, your ability to get oxygen from your bloodstream and into muscles has been diminished.

Thats because the key to unlocking oxygen from the bloodstream is C02 and big breaths taken while exhaling through your mouth are offloading C02 from the body at too high a rate to make efficient oxygen utilisation possible.

Heres an easy way to remember this next time that you train:

The amount of Co2 that you lose is the amount of oxygen that you cant use.

The knowledge of this basic physiological process becomes a competitive advantage for any athlete willing to train the following respiratory adaptations in order to master their breathing and improve their aerobic capacity:

You happen to have access to the most powerful and effective breathing machine ever created: the human nose.

The nose is designed for the purpose of up-taking oxygen, removing harmful particles from the atmosphere, warming air prior to entering the body and creating a highly pressurised flow of oxygen directly into the lungs and diaphragm. It also induces the release of nitric oxide, a potent vasodilator that widens the walls of your blood vessels creating a more effective pathway for oxygen rich blood to make it to muscles.

It may be smaller than the mouth, but thats the athletic advantage. If getting more oxygen into our bodies were the solution to avoid gassing out in workouts we would simply take bigger breaths. However, oxygen is in no short supply.

The ability to use available oxygen i.e, extract it from the hemoglobin in the bloodstream, which is the job of carbon dioxide, is the challenge that we face when training.

Nasal breathing allows us to increase our oxygen utilisation while decreasing the amount of C02 that we offload while training.

Keep in mind that C02 is not simply a waste gas, it is like oxygens teammate in a partner WOD. They work together and if one bales out, the others performance suffers.

Breathing through the nose can initially be difficult for many athletes. Therein lies the advantage for those willing to train the adaptation.

After a few weeks of consistent training, many athletes can perform at upwards of 90% max heart rate with nasal-only breathing. They uptake oxygen faster and more effectively and delay premature transitions into anaerobic respiration which come at the cost of increased metabolic waste to buffer.

They also remain fresh so that, if they do decide to shift to mouth breathing near the end of a workout in order to sprint to the finish, they are positioned for a powerful finish.

Use an assault bike, rower or ski erg and try the following 4 minute warm-up.

EMOM for 4 minutes:

Nasal breathing only. Put out as much wattage as the prescribed breathing cadence allows.

Before long you will be able to increase the wattage while sticking to the prescribed warm-up breathing pattern.

This is akin to doing pull-ups and push-ups for your breathing muscles while making the physiological adaptations to carbon dioxide that help separate you from the pack and break through those PR plateaus that weve all experienced.

Additional Training Tips

How you breathe post-workout will affect how quickly your heart rate returns to baseline levels as well as how effective your post-workout mobility session will be (you cant relax a body that is still in a high-stress state).

Your ability to recover more effectively sets you up for success in your next training session. This simple post-workout breathing exercise can help you optimise your recovery and get the most from your hard work:

As a CrossFit athlete, you train your body and you push it hard. Youve most likely already made nutritional changes to support your training and youve worked to prioritise sleep to support your recovery. Youve looked at the various pieces that make up the training puzzle and youve worked hard to put each one in place.

It just so happens that one of the most important puzzle pieces may have been right underneath our noses the whole time

Training comes down to getting oxygen to the body when it needs it most. No amount of willpower or dedication can outweigh the most basic and essential demands of our physiology. The more effective we become at using oxygen to fuel our athleticism, the higher we can raise the ceiling of our own performances potential.

David Bidler is a writer, speaker, and performance-breathing coach living in Portland, Maine. David owns The Distance Project: Strength and Conditioning. Follow him @the_distance_project on Instagram.

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Breathe to Perform: Improve Your Breathing To Unlock Hidden Athletic Potential - BOXROX

Biochemistry Analyzers Market Projected to Have a Stable Growth for the Next Few Years – The Denton Chronicle

Biochemistry analyzers are machines designed for analyzing blood, cerebral spinal fluid, urine, and other biological samples. These machines are equipped with electrochemical and optical technologies for measuring characteristics of the sample. Most of these analyzers use optical technologies for performing the measurements such as colorimetric, spectrometric, absorption, and fluoroscopic detection methods. These machines can also measure chemicals such as antigens, proteins, and molecules in body fluids. These analyzers offer several benefits such as fast measurement ability, accuracy, and high sensitivity when detecting even minuscule amount of chemicals.

On the basis of modality, the biochemistry analyzers market has been divided into bench top, and floor standing. Bench top analyzers are comparatively small in size and can be used with significant level of flexibility. In addition, in small laboratory settings, benchtop analyzes are preferred over space consuming floor standing analyzers. Considering the convenience benefits offered, growth rate of demand for bench top analyzers is expected to surpass the demand for floor standing analyzers during the forecast period.

On the basis of both value and volume, North America dominated the market in 2017. High penetration of these analyzers in countries such as U.S. and Canada are attributed to its strong base of pharmaceutical and healthcare sector. From supply side, many of the producers of biochemistry analyzers are located in this region and they have strong distribution channel penetration across hospitals, diagnostics centers, pharmaceutical and biotechnology companies, and academic research institutes.

Growth of the biochemistry analyzers market is hindered by factors such as its complex system integration is complex and high upfront cost. High upfront cost has dented its attractiveness among price sensitive customers in countries from Asia-Pacific.

Some of the major players operating in the global biochemistry analyzers market are Abbott, Siemens AG, Thermo Fisher Scientific, HORIBA, Ltd., F. Hoffmann-La Roche Ltd, Beckman Coulter Inc., Hologic, Inc., Danaher Corporation, Meril Life Sciences Pvt. Ltd., and Randox Laboratories Ltd.

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Biochemistry Analyzers Market Projected to Have a Stable Growth for the Next Few Years - The Denton Chronicle

Global Bench-top Veterinary Biochemistry Analyzers Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025 – Breakaway Trends

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Global Bench-top Veterinary Biochemistry Analyzers Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025 - Breakaway Trends

Global Biochemistry Analyzer Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025 – PR Industry News

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The research analysis for Biochemistry Analyzer market comprises each and every feature of the market all over the world, which starts from the Biochemistry Analyzer market description and ends on the Biochemistry Analyzer market segmentation (Semi-Automatic Biochemical Analyzers, Fully Automated Biochemistry Analyzers). In addition to this, each section of the Biochemistry Analyzer market is categorized and evaluated on the basis of goods, the end-user clients of the Biochemistry Analyzer market, and the employment of the products. The geographical categorization of the Biochemistry Analyzer market (Academic Research Institutes, Biotechnology Companies, Contract Research Organizations, Diagnostic Centres, Hospitals, Pharmaceutical Companies, Others) has also been evaluated thoroughly in the report.

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Biochemistry Analyzers Market Competitive Insights, Production Overview and Forecasts | Download Pdf Brochure – Crypto Journal

Coherent Market Insights recently published a detailed study of Biochemistry Analyzers Market covering interesting aspects of the market with supporting development scenarios ranging from 2018-2026. The report delivers the clean elaborated structure of the Market comprising each and every business-related information of the market at a global level. The complete range of information related to the Global Market is obtained through various sources and this obtained bulk of the information is arranged, processed, and represented by a group of specialists through the application of different methodological techniques and analytical tools such as SWOT analysis to generate a whole set of trade-based study regarding the Biochemistry Analyzers.

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The key players are highly focusing on innovation in production technologies to improve efficiency and shelf life. The best long-term growth opportunities for this sector can be captured by ensuring ongoing process improvements and financial flexibility to invest in optimal strategies. Few Market Key Players are Abbott, Danaher Corporation, F.Hoffman-La Roche Ltd., Siemens AG, Thermo Fisher Scientific, Inc., Randox Laboratories Ltd., Meril, Hologic Inc., Beckman Coulter Inc., and Horiba Medical.

This report examines and evaluates the market for a Biochemistry Analyzers at a global and regional scale. The market has been projected on the basis of revenue (USD Million) and volume (million square meters) from 2018 to 2026. The report further includes the different factors that are responsible for driving and restraining the growth of the market. It also covers the consequences of these driving and restraining factors on demand for the Market during the forecast period. The study also consists of potential growth opportunities in the global and regional markets.

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Brexit message as University of Cambridges Prof Paul Dupree and Prof Steve Jackson named as 2019 Highly Cited Researchers – Cambridge Independent

Two University of Cambridge scientists have been named as among the most influential researchers in the world - and responded with a message about Brexit.

Professor Paul Dupree and Professor Steve Jackson, of the Department of Biochemistry, were named as 2019 Highly Cited Researchers, as they research is among the top one per cent most cited worldwide.

Prof Dupree, who explores the extracellular matrix in plants and cell wall biosynthesis, said: I am very proud once again in 2019 to be named a Highly Cited Researcher. This reflects the outstanding work of our group members over many years to produce reproducible, exciting findings addressing the big questions in science that directly impact society, such as sustainable energy and material resources, and improvement of our diet.

He added: The result of the Brexit referendum has caused uncertainty and stress amongst my team members from other EU countries.

The UK must continue to attract the top students and researchers from elsewhere in the EU. We benefit in the UK from being fully integrated into many EU research programmes. The amazing high tech companies clustered around Cambridge are evidence of the impact top research in Cambridge has on job and wealth creation for the UK.

Prof Jackson, head of the Gurdon Institute's Cancer Research UK labs and the Frederick James Quick professor of biology, studies how our genomes remain stable, through processes such as DNA damage response.

It is a great honour to be on the list of 2019 Highly Cited Researchers, he said. This presumably reflects my laboratory's recent and past research publications having been well received by our peers in the research community.

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How Cambridge biochemist Prof Paul Dupree teamed up with his 80-year-old dad to solve plant mystery

Gurdon Institute research uncovers new genes responsible for genome stability

Prof Steve Jackson of Gurdon Institute wins prestigious European cancer research prize

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Brexit message as University of Cambridges Prof Paul Dupree and Prof Steve Jackson named as 2019 Highly Cited Researchers - Cambridge Independent

Agilent Receives Multiple Life Science Industry Awards for Innovation – BioSpace

SANTA CLARA, Calif.--(BUSINESS WIRE)--Agilent Technologies Inc. (NYSE: A) announced today that it has received two Life Science Industry Awards (LSIA) for Most Innovative New Products in 2019 fromBioInformatics Inc. Since 2002, the LSIA have recognized manufacturers of the tools of science that help advance biological research and drug discovery.

It is a great honor for our xCELLigence RTCA eSight, the latest addition to Agilents cell analysis portfolio, to receive one of the Most Innovative New Product in 2019 Award - Cell Biology from Bioinformatics

The Agilent products were theMagnis NGS Prep System, which received a Silver Award in the genomics category, and thexCELLigence RTCA eSight, which received a Bronze Award in the cell analysis category. Agilent was the only life sciences company nominated twice.

Id like to congratulate Agilent for winning not one, but two, Life Science Industry Awards in the categories of cell biology and genomics," said Craig Overpeck, CEO of BioInformatics Inc. xCELLigence RTCA eSight and the Magnis NGS Prep System are examples of Agilents innovative thinking and commitment to driving life science research forward.

The fully automated Magnis NGS Prep System includes reagents and protocols that make it easy to assay multiple genes and complex genetic aberrations from genomic DNA, including degraded samples such as formalin-fixed paraffin-embedded (FFPE).

With complex NGS library preparation, customers often struggle with retaining skilled lab personnel who can routinely produce high-quality results, said Kevin Corcoran, Agilent VP, and general manager for biomolecular analysis. The Magnis was designed as a turn-key automation solution to enable any lab to adopt NGS. Magnis has innovated library prep processing, ensuring optimized, reproducible results that work seamlessly with Agilents SureSelect platform.

The xCELLigence RTCA eSight provides label-free, real-time biosensor measurements, as well as kinetic imaging of the same live cell populations, independently, or simultaneously. It enables scientists to obtain unprecedented information and deep insight into cell health and their responses to a variety of chemical or biological manipulations across a wide spectrum of basic research and therapeutics fields, including cell biology, immunology, immuno-oncology, and immunotherapy.

"It is a great honor for our xCELLigence RTCA eSight, the latest addition to Agilents cell analysis portfolio, to receive one of the Most Innovative New Product in 2019 Award - Cell Biology from Bioinformatics," said Xiaobo Wang, Ph.D., who joined Agilent from ACEA, as general manager of the Flow Cytometry and Real-Time Cell Analysis Business. "The launch of xCELLigence RTCA eSight, with its highly multiplexing capabilities including real-time electronic biosensor measurements and live cell imaging with up to four independent, bright field and fluorescent channels, represents the frontier in live cell analysis. Now researchers can observe cell health and behavior in the greatest mechanistic details to analyze and more fully understand complex cellular environments and interactions through the entire course of the cell-based assay.

About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is a global leader in life sciences, diagnostics and applied chemical markets. Now in its 20thyear as an independent company delivering insight and innovation toward improving the quality of life, Agilent instruments, software, services, solutions, and people provide trusted answers to customers' most challenging questions. The company generated revenue of $5.16 billion in fiscal 2019 and employs 16,300 people worldwide. Information about Agilent is available atwww.agilent.com. To receive the latest Agilent news, subscribe to the AgilentNewsroom. Follow Agilent onLinkedIn,Twitter, andFacebook.

Naomi GoumilloutAgilent Technologies+1.781.266.2819naomi.goumillout@agilent.com

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Agilent Receives Multiple Life Science Industry Awards for Innovation - BioSpace

Scientists Shocking Discovery That Babies in the Womb May See Much More Than We Thought – SciTechDaily

An intrinsically photosensitive retinal ganglion cell (ipRGC) as it would appear if you looked at a mouses retina through the pupil. The white arrows point to the many different types of cells with which it networks: other subtypes of ipRGCs (red, blue and green) and retinal cells that are not ipRGCs (red). The white bar is 50 micrometers long, approximately the diameter of a human hair. Credit: Franklin Caval-Holme, UC Berkeley

By the second trimester, long before a babys eyes can see images, they can detect light.

But the light-sensitive cells in the developing retina the thin sheet of brain-like tissue at the back of the eye were thought to be simple on-off switches, presumably there to set up the 24-hour, day-night rhythms parents hope their baby will follow.

University of California, Berkeley, scientists have now found evidence that these simple cells actually talk to one another as part of an interconnected network that gives the retina more light sensitivity than once thought, and that may enhance the influence of light on behavior and brain development in unsuspected ways.

In the developing eye, perhaps 3% of ganglion cells the cells in the retina that send messages through the optic nerve into the brain are sensitive to light and, to date, researchers have found about six different subtypes that communicate with various places in the brain. Some talk to the suprachiasmatic nucleus to tune our internal clock to the day-night cycle. Others send signals to the area that makes our pupils constrict in bright light.

But others connect to surprising areas: the perihabenula, which regulates mood, and the amygdala, which deals with emotions.

In mice and monkeys, recent evidence suggests that these ganglion cells also talk with one another through electrical connections called gap junctions, implying much more complexity in immature rodent and primate eyes than imagined.

Given the variety of these ganglion cells and that they project to many different parts of the brain, it makes me wonder whether they play a role in how the retina connects up to the brain, said Marla Feller, a UC Berkeley professor of molecular and cell biology and senior author of a paper that appeared this month in the journal Current Biology. Maybe not for visual circuits, but for non-vision behaviors. Not only the pupillary light reflex and circadian rhythms, but possibly explaining problems like light-induced migraines, or why light therapy works for depression.

The cells, called intrinsically photosensitive retinal ganglion cells (ipRGCs), were discovered only 10 years ago, surprising those like Feller who had been studying the developing retina for nearly 20 years. She played a major role, along with her mentor, Carla Shatz of Stanford University, in showing that spontaneous electrical activity in the eye during development so-called retinal waves is critical for setting up the correct brain networks to process images later on.

Hence her interest in the ipRGCs that seemed to function in parallel with spontaneous retinal waves in the developing retina.

We thought they (mouse pups and the human fetus) were blind at this point in development, said Feller, the Paul Licht Distinguished Professor in Biological Sciences and a member of UC Berkeleys Helen Wills Neuroscience Institute. We thought that the ganglion cells were there in the developing eye, that they are connected to the brain, but that they were not really connected to much of the rest of the retina, at that point. Now, it turns out they are connected to each other, which was a surprising thing.

UC Berkeley graduate student Franklin Caval-Holme combined two-photon calcium imaging, whole-cell electrical recording, pharmacology and anatomical techniques to show that the six types of ipRGCs in the newborn mouse retina link up electrically, via gap junctions, to form a retinal network that the researchers found not only detects light, but responds to the intensity of the light, which can vary nearly a billionfold.

Gap junction circuits were critical for light sensitivity in some ipRGC subtypes, but not others, providing a potential avenue to determine which ipRGC subtypes provide the signal for specific non-visual behaviors that light evokes.

Aversion to light, which pups develop very early, is intensity-dependent, suggesting that these neural circuits could be involved in light-aversion behavior, Caval-Holme said. We dont know which of these ipRGC subtypes in the neonatal retina actually contributes to the behavior, so it will be very interesting to see what role all these different subtypes have.

The researchers also found evidence that the circuit tunes itself in a way that could adapt to the intensity of light, which probably has an important role in development, Feller said.

In the past, people demonstrated that these light-sensitive cells are important for things like the development of the blood vessels in the retina and light entrainment of circadian rhythms, but those were kind of a light on/light off response, where you need some light or no light, she said. This seems to argue that they are actually trying to code for many different intensities of light, encoding much more information than people had previously thought.

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Reference: Gap Junction Coupling Shapes the Encoding of Light in the Developing Retina by Franklin Caval-Holme and Marla B. Feller, 7 November 2019, Current Biology.DOI: 10.1016/j.cub.2019.10.025

The research was supported by the National Institutes of Health (NIH F31EY028022-03, RO1EY019498, RO1EY013528, P30EY003176).

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Scientists Shocking Discovery That Babies in the Womb May See Much More Than We Thought - SciTechDaily

Six professors named 2019 fellows of the American Association for the Advancement of Science – UCLA Newsroom

The American Association for the Advancement of Science, which is the worlds largest scientific society, has named six UCLA faculty members as 2019 fellows. Since 1874, the AAAS, which publishes the journal Science, has chosen members for their distinguished efforts to advance science or its applications.

UCLAs new fellows are:

Paula Diaconescu, professor of chemistry and biochemistry. Diaconescus research focuses on the design of reactive metal complexes with applications to small molecule activation, organic synthesis and polymer formation. She is being honored for seminal contributions to the field of catalysis, particularly for applications of switchable catalytic systems to block copolymer synthesis.

David Glanzman, professor of integrative biology and physiology and of neurobiology. Glanzman studies the cell biology of learning and memory in marine snails and the zebrafish. He transferred a memory from one marine snail to another in 2018, thereby creating an artificial memory. Glanzman is being honored for his groundbreaking research on learning and memory, particularly on memory consolidation and erasure.

Margaret Jacob,distinguished professor emeritus of history. Jacobs expertise includes the history of science and intellectual history. She has played a critical role in shedding light on how the scientific and theoretical advancements of the Enlightenment worked their way into the mainstream of 17th- and 18th-century life. Jacob is being honored for distinguished and groundbreaking contributions to the cultural history of the Scientific Revolution, Newtonianism, and the Enlightenment, and effective communication of these to wider audiences.

Thomas Mason, professor ofphysical chemistry and professor of physics. Masons experimental research focuses on designing and studying new forms of soft matter that have innovative multi-scale dynamic micro- and nano-architectures and morphologies. He is being honored for distinguished contributions to the field of soft matter, particularly for creating and developing thermal-entropic passive microrheology, and for advances in emulsification and nanoemulsions.

Dr. Stephen Smale, vice dean for research at the at the David Geffen School of Medicine at UCLA and distinguished professor in the department of microbiology, immunology and molecular genetics. Smales research addresses the molecular mechanisms of gene regulation in cells of the immune system. He is being honored for distinguished contributions to the field of transcriptional regulation of eukaryotic gene expression, particularly in the immune system.

Yang Yang, professor of materials science and engineering, and the Carol and Lawrence E. Tannas, Jr. Professor of Engineering at the UCLA Samueli School of Engineering. Yangs research involves advanced technologies in thin film solar cells, transparent conductors, metal oxide transistors and other electronic devices, and has large potential for future applications at extremely low cost. He is being honored for extraordinary contributions to organic and hybrid electronic materials and interface processing, leading to highly efficient solar cells, digital memory, and organic displays.

A total of 443 scholars were selected as fellows this year. They will be honored Feb. 15, 2020, at the associations annual meeting in Seattle.

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Six professors named 2019 fellows of the American Association for the Advancement of Science - UCLA Newsroom