The Real Glue-Trapping Scandal – Fair Observer

Over centuries, Europeans have developed local traditions that define the economy, the arts and the rituals of daily life. Those traditions sometimes belong to nations or are spread across the entire continent. Sometimes they are very local and remain unknown beyond a small region. The institutions of the European Union have made an effort to regulate and even suppress some of those practices as well as preserve and protect many others, particularly those that have been endangered by modernity.

The Guardian highlights one example of a traditional hunting practice in the southeast of France called la chasse la glu or glue-trapping. The practice consists essentially of using the calls of encaged songbirds to incite unsuspecting members of the same species to land on sticks placed nearby that have been coated with glue. After landing, the birds become literal sitting ducks for the hunters to aim at. The practice turns out to be doubly cruel because the hunters capture and cage living birds whose calls attract the free birds that will be killed by the hunters.

As The Guardian reports, glue-trapping was banned in the EU by a 1979 directive, except in special circumstances where it is controlled, selective and in limited quantities. Since 1989, France has invoked these circumstances to permit glue-trapping in five south-east departments on the grounds that it is traditional.

Here is todays 3D definition:

Glue-trapping:

A traditional French hunting method for catching and killing birds, by which the victims are enticed through pleasurable and flattering messages to an area in the wilderness where sticks covered with glue are placed by hunters to prevent the birds from escaping, a strategy carefully imitated by the marketing minds of commercial social media

In the name of protecting the ecosystem and minimizing the degree of cruelty and suffering related to hunting, European law forbids the practice, but French law permits it as a recognition of a time-honored traditional practice linked to the local economy. The hunters claim glue-trapping dates back at least several family generations, and reject accusations of cruelty, The Guardian reports.

The avoidance of cruelty has become a cultural norm in the modern world, especially in Europe, where cruelty to humans is severely repressed, as witnessed by the disappearance throughout Europe of the death penalty. The glue-trapping hunters base their claim of legitimacy on three criteria: the universally recognized tolerance of hunting as a strategy for survival (even if modern hunters can survive without hunting), the consecration of time (tradition) and genealogy (family). The last two values tradition and family are specifically important in southern French culture. They have less impact or persuasive value in northern European countries.

The tolerance of hunting is universal and has always been regulated by complex laws. Despite its universal acceptance, in recent times anti-hunting movements have emerged, focusing on the question of unmerited cruelty to prey. The hunters argument based on time and tradition appeals to the psychological and sociological principle of cultural inertia that clearly influences law, as a factor of social stability and historical continuity. Time-honored practices that may grate against modern sensibilities can continue to survive, thanks to their perception as being rooted in what may be thought of as an ecology of human behavior. This is especially true if there is an economic dimension and the practices impinge on the struggle for survival.

Todays European political and economic news contains an extreme illustration of that principle, far more significant than the question of glue-trapping. An initiative against tax havens has been voted down by states who cannot afford to lose the revenue such status brings, The Guardian reports. The reason cited is the reliance of these countries on artificially favorable corporate tax rates granted by some countries to big US tech companies. These corporations thus find a way to avoid paying taxes in the countries where they do business. The article notes that too many influential countries are now utterly dependent on being tax discounters. It concludes that countries such as Malta, Cyprus and Ireland need to be compensated in some way to ease them through a transition period.

In the case of European tax evasion, it isnt clear who is luring whom to the trap, since the countries use their favorable tax policies to lure the corporations and glue them into their economic fabric. But the corporations are the big winners, unlike the caged birds. They use their economic clout to lure the countries into granting them favors. The countries remain glued to their sticks.

The solution that The Guardian proposes would be compensation for the loss of revenue. Its unlikely that a similar solution to glue-trapping could exist. Still, after so many years of failure, the critics of the practice might be wise to imagine an approach similar to the one recommended for the tax issue: These countries need a carrot and not just a stick. And certainly not a gluey stick.

The bird campaigners who seek a total ban on the practice appear to have turned their lobbying campaign into something of a tradition with its own cultural inertia. With their repeated forays over the past 30 years to gather evidence and present it to European courts having failed, they have now quite logically resorted to taking their case to the court of public opinion by offering journalists an opportunity to appeal to their readers shared sense of indignation at unnatural practices. The intention is good but the approach is bound to be ineffective. Weve concrete evidence that sometimes the bird is struggling for 20-30 minutes, says Yves Verilhac of Ligue pour la Protection des Oiseaux (LPO). Its the sometimes that hurts. Things that happen sometimes rarely justify changing behaviors rooted in tradition or passing laws that will only create local friction.

The discourse of the critics can appear to be less about cruelty than an attack on the very idea that tradition and cultural inertia can sometimes trump legal principles. One critic commented, This is what they call tradition, but its a practice from the middle ages and barbaric.

Hunting in the middle ages was most likely less barbaric than today. Apart from a few privileged aristocrats a tiny proportion of the population, who hunted only on rare occasions common people hunted, when it was permitted, for survival. Killing always involves cruelty, but anyone who isnt a vegan learns to live with it. With everyones survival now ensured by the existence of supermarkets, hunting has become a sport and a leisure activity.

And todays sport is possibly far less disciplined and regulated by tradition than the sport practiced by medieval aristocrats. US vice presidents, for example, have even been known to shoot their friends in the face, though the vice president in question, Dick Cheney, had few qualms about ordering the killing of thousands of people who werent his friends.

The glue-trap hunters, after all, have a point. I say to people: You dont like hunting, thats fine. I respect your view, but leave me alone. I probably dont like some things you do but thats your decision, your life. Its hardly a valid excuse for undue cruelty to animals, but if the courts have not found the detective work of the bird campaigners convincing enough to force the application of the law, their eagerness to expose the crime begins to resemble a form of harassment.

The real lesson of the story should come from seeing it as a parable rather than a serious social problem. Whether its the practice of certain social media seeking to lure people into a trap and glue them to a stick (e.g., your Facebook page) as repeat consumers who subsequently leave their feathers and much of their flesh (personal data) in the hands of the corporation that runs the media, or whether its the corporations that have cemented needy governments into their geopolitical tax schemes, glue-trapping can be seen as a metaphor for the most effective marketing schemes of modern times.

*[In the age of Oscar Wilde and Mark Twain, another American wit, the journalist Ambrose Bierce, produced a series of satirical definitions of commonly used terms, throwing light on their hidden meanings in real discourse. Bierce eventually collected and published them as a book, The Devils Dictionary, in 1911. We have shamelessly appropriated his title in the interest of continuing his wholesome pedagogical effort to enlighten generations of readers of the news.]

The views expressed in this article are the authors own and do not necessarily reflect Fair Observers editorial policy.

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The Real Glue-Trapping Scandal - Fair Observer

The Ethics of the devil – Arutz Sheva

A distinction is often made between Judeo-Christian ethics and Islamic ethics. Judeo-Christian ethics are supposedly mild and compassionate, whereas Islamic ethics embrace aggressiveness and violence. Nevertheless, my decade-long experience in social media suggests that fundamentalist Christians can be no less aggressive than their Islamic counterparts in denouncing not only each other, but also homosexuals, abortion activists and progressive politicians.

Even though traditional Judaism is opposed to these practices,few practicing Jews indulge in the demonization of opponents which is so fashionable in other milieus. This reluctance to paint adversaries with a broad brush encompasses Jewish attitudes to Muslims, which, far from being as hostile as the latest eight decades might warrant, are remarkably nuanced.

In order to understand why in many respects Christians and Muslims seem to be on the same page in their reaction to hostile forces, I propose a distinction between the combative ethics dear to most Muslims and many Christians and the constructive ethics embraced by Jews.

A combative view of ethics calls upon us to fight evil wherever it is found. A constructive view of ethics calls upon us to fight for goodness whenever possible. Thus, the person devoted to combative ethics will fight poverty, injustice and oppression, whereas the person devoted to constructive ethics will fight for wealth-redistribution (or wealth-creation), justice and freedom. This is not an academic distinction, but a crucial difference based on our essential understanding of ethics as primarily a fight against evil or a struggle for goodness.

At first glance, it appears unfair to distinguish Christianity from Judaism in this regard. After all, the Christian Gospels are less militant than most books found in the Hebrew Bible. It is Jesus, not the Prophets who invites his followers to love their enemies and turn their cheeks to them. Nevertheless, it is clear that most Christians dont subscribe to the literal meaning of these words. This is not just a reflection of how hard and unrealistic such a course of action usually is. Tolerating evil also clashes with the Christian imperative to resist and oppose Satan.

In the Jewish tradition, Satan plays a very limited role. The Satan, or Ha-Satan, is merely the heavenly prosecutor who makes a case in the divine court against the sincerity of righteous figures like Abraham and Job. This is a far cry from the role that Christianity and Islam assign to Satan. Both in Christianity and in Islam the devil is a powerful force that opposes Gods designs and lures men and women to sin and perdition. In this regard, fighting and defeating the devil in Islam and Christianity is a prerequisite for Gods earthly will to be realized.

The importance attributed to the devil in a culture and religion is directly related to its inclination to engage in combative ethics vis--vis constructive ethics.The importance attributed to the devil in a culture and religion is directly related to its inclination to engage in combative ethics vis--vis constructive ethics. In a world where Satan is viewed as omnipresent, goodness can only be achieved by fighting evil. In a world where the devil does not exist, the temptation to view ethics as a fight against evil is less appealing. It is thus not surprising that in Islamic milieus where the devils presence is acutely felt, the lure of combative ethics is far stronger than in Judaism or contemporary Christianity.

During many centuries Christianity was also under the spell of Satan. The massacres of cats which facilitated the plague, the Salem witch trials and the rhetoric of clericalist parties which in the 19th and early 20th century labelled progressive adversaries as satanic, highlights the crucial role of the devil in the Christian consciousness and ethical worldview. This is the most plausible reason to explain why both Islamists and Christian fundamentalists tend to demonize opponents in a way that is alien to the attitude of most observant Jews.

Focusing on the devil in order to account for differences in human behavior and worldviews in the 21st century may appear absurd. Nevertheless, given that the Manichaean worldview of Islamists and fundamentalist Christians is not shared by people who do not believe in the devil, it makes sense to pursue further research that ascertains how individual and collective attitudes towards the devil and ethics interact and shape each other.

It would be therefore extremely interesting to research whether the role people accord to the devil correlates with their preference for combative vis--vis constructive ethics. A scientific demonstration of this relationship could shed light on a crucial cultural and psychological factorand on the malignant shade the devil casts to this day.

Researchers and academics are welcome to contact the author atrafaelcastro78@gmail.comto jointly pursue this research project.

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The Ethics of the devil - Arutz Sheva

Why the World Needs Bloodsucking Creatures | Science – Smithsonian

In a sprawling gallery of the Royal Ontario Museum, curators and technicians crowded around two large coolers that had recently arrived at the Toronto institution. Wriggling inside the containers were live sea lampreys, eel-like creatures that feed by clamping onto the bodies of other fish, puncturing through their skin with tooth-lined tongues, and sucking out their victims blood and bodily fluids. Staff members, their hands protected with gloves, carefully lifted one of the lampreys and plopped it into a tall tank. It slithered through the water, tapping on the glass walls with its gaping mouth, rings of fearsome teeth on full view.

Having explored its new environment, the lamprey settled onto the pebbles at the bottom of the tank. It will remain on display until March as part of a new exhibition exploring the oft-reviled critters that bite, pierce, scrape and saw their way through flesh to access their favorite food source: blood.

The exhibition, called Bloodsuckers, includes displays of other live animalsmosquitoes, ticks and leechesinterspersed throughout the gallery. And dozens of preserved specimens, arrayed down a long, curving wall, offer a glimpse into the diverse world of the roughly 30,000 species of bloodthirsty organisms across the globe. Among these critters are vampire moths, which can pierce the thick skins of buffalo and elephants. Vampire snails target sick and dying fish, making for easier prey. The oxpecker birds of Africa pluck ticks and other insects off large mammalsand then slurp blood from their hosts sores.

Sebastian Kvist, curator of invertebrates at the Royal Ontario Museum and co-curator of the exhibition, knows that these animals are likely to make some visitors shudder. But to him, blood-feeders are the loveliest of organisms, the result of a refined evolutionary process. Leeches are a particular favorite of Kvists, and his research focuses on the evolution of blood-feeding behavior, or hematophagy, in these predatory worms. Sometimes he even affectionately lets the leeches in his lab gorge themselves on his blood.

When you have live animals in your care, they demand some respect, he says. I think that it is giving back to the leech what we're getting from them to donate our warm blood.

Bloodsuckers opens in a corridor bathed in red light, where an installation featuring three strands of red blood cells dangles from the ceiling. Blood is a hugely abundant food source, so it makes sense that wherever vertebrates exist, animals would arise to steal their life-sustaining fluids. Blood-feeding likely evolved repeatedly over the course of our planets historyperhaps as many as 100 times, according to Kvist. Bloodsucking creatures have no common ancestor, as the behavior has cropped up independently in birds, bats, insects, fish and other animal groupsa testament to its evolutionary value.

I can think of no other system thats [so] intricate that has evolved separately, Kvist says. And it makes blood-feeding as a behavior even more beautiful.

Subsisting on a blood-heavy diet is tricky, however, and relatively few creatures have managed to retain this ability over time. Thirty thousand [bloodsuckers] out of the roughly 1.5 or 1.6 million species [of animals] that have been described is a very, very small number, Kvist says. But it turns out that being able to feed on blood puts tremendous strain on your physiology, on your morphology, and on your behavior.

For one, blood lacks B vitamins, which all animals require to convert food into energy. Many bloodsuckers thus host microscopic bacteria inside their bodies to provide these essential nutrients. Because blood is so iron-rich, its toxic to most animals in large amounts, but habitual blood-feeders have evolved to break it down.

Getting to the blood of a living creature is no mean feat either. Blood-feeding organisms have different ways of accessing their preferred snack. Mosquitoes, for instance, pierce the skin with their long, thin mouthparts, while certain biting flies boast serrated jaws that slash through flesh. But all of these methods risk being met with a deft swat from the host. To counteract this problem, some blood-feeders, like leeches, have mild anesthetics in their saliva, which help them go unnoticed as they feed. Certain creatures like vampire bats, lampreys and leeches also produce anticoagulants to keep their victims blood flowing, sometimes even after theyre done eating.

A leech feeds five times its body weight in blood, up to ten times sometimes, Kvist says. If that blood congealed or clotted inside its body, then the leech would fall to the bottom [of the water] like a brick.

Kvist and Doug Currie, the Royal Ontario Museums senior curator of entomology and co-curator of the exhibition, hope museum visitors gain a newfound appreciation for the elegance of bloodsucking organisms. Humans share a long and complicated relationship with blood-feeders. Leeches, for instance, were once seen as a life-saving force, and are in fact still used by medical experts today after certain types of surgery that overfull parts of the body with blood. But at the same time, we are unnerved by creatures that steal blooda wariness that has persisted for centuries, as suggested by the fearsome bloodsuckers that populate folklore traditions around the world.

A natural history and culture institution, the Royal Ontario Museum also explores how blood-feeding, a trait that exists in nature, has crept into the human imagination and morphed into something fantastical. Monsters abound within the gallery. There are models of the chupacabra, a beast rumored to drain livestock of their blood, and the yara-ma-yha-who, which originated in the oral traditions of Australia and boasts blood suckers on its fingers and toes.

These creatures do not directly resemble any real blood-feeding animal. Instead, they speak to our innate fear of something taking our life force, says Courtney Murfin, the interpretive planner who worked with curators to craft the exhibitions narrative.

Dracula, arguably the most famous of all the fictional bloodsuckers, may have a more tangible connection to the natural world. Legends of vampires predate Bram Stokers 1897 novelvisitors can see a first edition copy of the book at the exhibitionbut the notion that these undead beings could transform into bats originated with Dracula. Vampire bats, which live in Mexico and Central and South America, feed on the blood of mammals and birds. They were first described in 1810 and documented by Charles Darwin in 1839. The animals may have influenced Stokers supernatural count.

Depictions of vampires in todays popular culture run the gamut from cool to sexy to goofy. We can have fun with them now, Murfin says, because we know they arent real. But when vampire lore arose in eastern Europe in the early 1700s, the beasts were a source of true terror. Confusion about normal traits observed in decomposing bodies, like swollen stomachs and blood in the mouth, led to the belief that corpses could rise from their graves to feast on the blood of the living.

They started digging up graves and staking the people to the ground so they couldn't stand up at night, Kvist says.

Fears about losing their blood to vampires did not, however, dampen Europeans enthusiasm for bloodletting, an age-old medical practice that sometimes involved applying leeches to the skin. The treatment can be traced back to the ancient world, where it arose from the belief that draining blood helped rebalance the bodys humors: blood, phlegm, yellow bile and black bile. Bloodletting reached its peak in the late 18th and early 19th centuries, when a leech mania swept across Europe and America. Pharmacies stored the critters in ornate jarsone is on display at the museumand Hirudo medicinalis, or the European medicinal leech, was harvested to the brink of extinction.

Bloodletters also had other ways of getting the job done. One corner of the exhibition is packed with a grisly assortment of artificial bloodletting tools: scarificators, which, with the push of a lever, released multiple blades for opening up the skin; glass cups that were heated and suctioned onto the skin, drawing blood to the surface; smelling salts, in case the procedure proved a bit too overwhelming for the patient.

While medical professionals no longer believe that leeching can cure everything from skin diseases to dental woes, leeches are still valued in medicine today. Hirudin, the anticoagulant in leech saliva, is unrivalled in its strength, according to Kvist. Its synthesized in labs and given to patients in pills and topological creams to treat deep vein thrombosis and prevent strokes. Leeches themselves make appearances in hospitals. Theyre helpful to doctors who perform skin grafts or reattachments of fingers, toes and other extremities. Newly stitched arteries heal more quickly than veins, so blood that is being pumped into the reattached area doesnt flow back into the body, which can in turn prevent healing.

Stick a leech on, and it will relieve that congestion of the veins, says Kvist, who also studies the evolution of anticoagulants in leeches.

Earlier this year, Kvist received a call from Parks Canada asking for help with an unusual conundrum. A man had been apprehended at Torontos Pearson International Airport with nearly 4,800 live leeches packed into his carry-on luggage, and officials needed help identifying the critters. Kvist took a look at some of the leeches, which appeared to have been smuggled from Russia, and pinpointed them as Hirudo verbana. Because they are threatened by over-harvesting, this species is listed by the Convention on International Trade in Endangered Species of Wild Flora and Fauna, meaning it cannot be transported without a permit. Just what the man was doing with the bloodsuckers is unclear, but Kvist says he claimed to sell them for New Age medicinal purposes.

There is a larger-than-we-think underground network of people that use leeches to treat a variety of ailments, Kvist says. The Royal Ontario Museum took in around 300 of the contraband critters, and a few dozen are presently lounging in a display tank at Bloodsuckers.

While leeches have long been valued for their healing propertiesscientifically valid or otherwisesome bloodsuckers are better known for their ability to transmit serious illnesses. Certain species of mosquito, for instance, spread West Nile, Zika and malaria. Ticks transmit Lyme disease. The exhibition does not shy away from exploring the dangers associated with blood-feeders, and it offers advice on how to protect yourself from infection.

Some fears are real, Kvist says. Disease, unfortunately, is a necessary consequence of blood-feeding.

Most blood-feeding animals, though, do not pose a serious threat to humans. In fact, bloodsuckers are vital to the health of our planet. Mosquitoes are an important food source for birds. Fish eat leeches. Even sea lampreys, which are invasive to the Great Lakes, can bring essential nutrients to the aquatic habitats where they spawn. And like all species, blood-feeders contribute to the Earths biodiversitya richness of life that is fast declining due to factors like pollution, climate change and habitat degradation.

Many, many animal groups need to be part of conversations regarding biodiversity, Kvist says, but he and his colleagues opted to spotlight the bloodthirsty ones. The museum hopes to help visitors feel more comfortable living alongside these animalseven if they arent willing to volunteer an arm for a leechs next meal.

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Why the World Needs Bloodsucking Creatures | Science - Smithsonian

Sleep, but not too much, to boost your heart health – CU Boulder Today

Key takeaways

Too much or too littlesleepcan magnify heart attack risk.

Those who slept fewer than six hours were 20% more likely to have a heart attack.

Those who slept more than nine hours were 34% more likely to have a heart attack.

Want to cut your risk of having a heart attack by as much as a third? Get some zzzs. But not too many.

Thats the takeaway from new CU Boulder research suggesting sleepsuch asdiet and exercisecan play a key role in promoting cardiovascular health.

Just as working out and eating healthy can reduce your risk of heart disease, sleep can too, says sleep researcher Celine Vetter, an assistant professor of Integrative Physiology.

In a study, published in the Journal of the American College of Cardiology, Vetter found that even if you are a healthy non-smoker who exercises and has no genetic predisposition to heart disease, skimping on sleepor getting too much of itcan significantly boost your risk of heart attack.

The magic number for heart-healthy slumber, the study found, lies somewhere between six and nine hours nightly.

For the study, Vetter and co-authors at the Massachusetts General Hospital and the University of Manchester, analyzed the genetic information, self-reported sleep habits and medical records of 461,000 people ages 40 to 69 who had never had a heart attack, then followed them for seven years.

Compared to those who slept six to nine hours per night, those who slept fewer than six hours were 20% more likely to have a heart attack. Those who slept more than nine hours were 34% more likely.

The farther people fell outside that ideal range, the more their risk increased. For instance, people who slept five hours per night had a 52% higher risk of heart attack than those who slept seven to eight hours, while those who slept 10 hours nightly were twice as likely to have one.

The upside: Even study subjects with a genetic predisposition to heart disease were able to counteract that risk by as much as 18% by getting the right amount of sleep.

This study provides some of the strongest proof yet that sleep duration is a key factor when it comes to heart health, and this holds true for everyone, said Vetter.

The looming question: What exactly does lack of sleep, or too much of it, do to the heart? More studies are underway, but earlier research has offered some hints.

Sleeping too little can damage the lining of the arteries and lead to poor dietary choices and ill-timed eating all bad things for the ticker. Sleeping too much, on the other hand, may boost inflammation throughout the body, fueling a host of health problems.

Vetters advice for hitting that sleep sweet spot: Shoot for seven to eight hours of quality sleep nightly.

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Sleep, but not too much, to boost your heart health - CU Boulder Today

Win two months supply of CBD tea as new company aims to make the North East calmer – Sunderland Echo

Marketed for its medicinal benefits to help alleviate stress, aid restful sleep and manage pain, cannabidiol (CBD) is found in cannabis plants.

However, unlike the THC associated with marijuana, CBD is legal and is said to harness the natural properties of the plant which regulate mood and sleep patterns without the addictive and psychoactive side effects.

Now businessman Chris Davison has blended water soluble CBD with tea to create company Teacan, which offers four different flavours of CBD-infused whole leaf tea.

Chris, who has a background in physiology and working for a large pharmaceutical company, spoke at a wellness event at North Sands Business Centre in Roker to dispel some of the myths around CBD.

He explained: CBD has been around for years but because of political sensitivities and out of date ideas, its only become more mainstream and accepted recently.

Speaking about how he became interested in the product, he said: Ive always been interested in the illegality of drugs, how some are demonised and some are socially acceptable.

I started looking into CBD out of interest. I was sceptical at first and wondered why it had such a wide range of benefits, but the more I looked into the physiology side of things the more and more convinced I became.

Like most people I have sleep issues, its a common thing, but I thought it would be great if I could have CBD as a tea before bed, without the taste of CBD which isnt very nice.

I already had a software business, so this business was more of a passion project but its generated a lot of interest. Im not selling a magic pill here, its very much about using CBD as part of wider holistic approach, but Ive already had great feedback from people.

Although growing the cannabis plant is illegal without a licence in the UK, Chris, who legally imports his CBD from Europe, believes a regulated industry could open up the benefits of CBD to more people at a higher quality.

Cannabis for medicinal purposes was made legal in the UK in 2018 and can be prescribed by certain registered medical professionals.

*Teacan offers four different types of CBD tea: English breakfast; cherry, coconut and kiwi; lemongrass and ginger and peppermint. We have two months supply to give away, based on one cup a day, which amounts to a box of each flavour.

To be in with a chance of winning the prize, worth more than 50, answer this question: name a flavour of Teacan tea? Email your answer, along with your address, to Katy.Wheeler@jpimedia.co.uk by December 10. Usual JPI Media competition rules apply.

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Win two months supply of CBD tea as new company aims to make the North East calmer - Sunderland Echo

Could Fruit Flies Reveal the Hidden Mechanisms of the Mind? – Scientific American

What is the biological basis of thought? How do brains store memories? Questions like these have intrigued humanity for millennia, but the answers still remain largely elusive.

You might think that the humble fruit fly, Drosophila melanogaster, has little to add here, but since the 1970s, scientists have actually been studying the neural basis of higher brain functions, like memory, in these insects. Classic workperformed by several labs, including those of Martin Heisenberg and Seymour Benzerfocused on studying the behavior of wild-type and genetically mutated Drosophila in simple learning and memory tasks, ultimately leading to the discovery of several key molecules and other underlying mechanisms. However, because one could not peer into the brain of behaving flies to eavesdrop on neurons in action, this field, in its original form, could only go so far in helping to explain the mechanisms of cognition.

In 2010, when I was a postdoctoral researcher in the lab of Michael Dickinson, we developed the first method for measuring electrical activity of neurons in behaving Drosophila. A similar method was developed in parallel by Johannes Seelig and Vivek Jayaraman. In these approaches, one glues a fly to a custom plate that allows one to carefully remove the cuticle over the brain and measure neural activity via electrodes or fluorescence microscopy. Even though the fly is glued in place, the animal can still flap her wings in tethered flight or walk on an air-cushioned ball, which acts like a spherical treadmill beneath her legs.

These technical achievements attracted the attention of the Drosophila neurobiology community, but should anyone really care about seeing a fly brain in action beyond this small, venerable, group of arthropod-loving nerds (of which I'm honored to be a member)? In other words, will these methods help to reveal anything of general relevance beyond flies? Increasingly, the answer looks to be yes.

There exist a few dozen cells that project neural fibers into a doughnut-shaped structure in the middle of the fly brain, with each cell branching to fill one of 16 pizza-slice-like wedges that make up the donut. Seelig and Jayaraman first imaged the activity of these neurons in walking flies using fluorescence microscopy via the new methods just described. Remarkably, they observed that this population of cells expresses a single "bump" of neural activity that stably persists at one position around the doughnut while a fly stands still and this activity bump rotates around the doughnut, like a compass needle, when the fly turns left or right.

The bump updates its position around the doughnut most accurately if the fly is given a visual cue that indicates her angular heading as she turns on the floating ball. However, even in complete darkness the bump is still present in the brain, and its position around the doughnut tracks the flys orientation (though not as precisely as with a visual cue). These results convincingly argued that flies have an internal sense of orientation, similar to our own sense of orientation in an environment that persists even after we close our eyes.

A graduate student in my lab, Jonathan Green, pushed things one step further. He described a neural circuit mechanism that explains how the activity bump rotates around the doughnut, even in complete darkness, guided by the fly's internal sense of how fast and in which direction she senses herself to be turning. (A similar circuit was concurrently described by Dan Turner-Evans and Stephanie Wegener in Vivek Jayaraman's lab.) Moreover, in our newest work, Jonathan Green, alongside a postdoctoral researcher, Vikram Vijayan, and another graduate student, Peter Mussells Pires, described how flies use the bump of activity to guide navigational behavior.

Specifically, we showed that the fly uses the position of the bump in the doughnut as a compass-like estimate of current heading that is compared with a goal heading (the angle along which the fly wishes to be heading), to determine which way to turn andquantitativelyhow hard to turn and how fast to walk forward. This same basic mechanism is very likely at play in the brains of bees, ants and other more-expert insect navigators, as they make their foraging trips away from and back to the nest.

In the 1980s, James Ranck and Jeff Taube discovered the so-called head-direction cells: neurons in mammals whose physiological properties bear a striking resemblance to the compass neurons just described in flies. Humans almost certainly have head-direction cells as well. In humans or other mammals, however, a neural circuit to explain how head-direction-cell activity updates as one turns remains elusive to this day, as does the precise functional role that these neurons serve in navigation. Thus, apart from insects, our work in Drosophila is laying a foundation that could serve as a road map for analyzing how bigger brains, perhaps even our own, might construct a sense of orientation and use that internal sense to guide navigational actions.

Beyond angular orientation, our understanding of how we remember locations in 2-D or 3-D space or how we perform nonspatial cognitive operationslike keeping track of elapsed time or predicting the likelihood of events happening in the futureremains similarly fuzzy. This is not to say that there has been no progress. Neurons whose physiological activity correlates with many such processes have been found in the mammalian brain, and scientists are even able to artificially activate and inactivate those neurons in behaving animals. However, we still do not have a comprehensive understanding of how brains produce an internal sense of space, time or value, nor how such internal senses guide behavior.

Luckily, Drosophila appear to implement versions of the abovementioned cognitive processes (and likely many others). Because Drosophila offers a small brain alongside some of the most advanced genetic, anatomical and physiological methods in neuroscience, I and others in my field believe that the first detailed neural mechanisms for explaining how such mental processes are implemented will become clear in this insect over the coming years. Our recent success in the angular heading domain could represent the tip of the iceberg with regard to how the fly could make plain the mechanisms underlying many other cognitive operations.

Overall, flies have not been bit players in the history of biology. It is by studying Drosophila that we first learned that genes physically reside on chromosomes, that a transcriptional feedback loop generates the circadian rhythms that pervade almost all life on earth, and that hox genes act as master regulators of body morphogenesis. Given the foundational role served by Drosophila in genetics, circadian rhythms, development and many other fields of science, it should perhaps be of little surprise to see Drosophila now serving a similarly pioneering role in cognitive neuroscience. Research projects that might take years or decades to complete in a rat or a monkey, might take only months to conclude in Drosophila.

This difference means that one can take bigger risks when studying flies and pursue seemingly intractable questions more readily, without betting one's entire career on a specific answer turning out to be correct. As the fly community amasses initial answers on how Drosophila implement their cognitive computationseven if they are in a reduced form compared to ourswe hope to inspire directed tests for similar mechanisms in mammalian brains, where the initial exploratory work is harder to perform.

One particularly intriguing aspect of studying neurobiology in Drosophila is the possibility of unifying our understanding of cognition at the gene, cell and circuit levels. Most disorders of the mind, like Alzheimer's disease and other dementias, arise from molecular abnormalities in genes that are largely conserved across humans and flies. Intense efforts have been placed on understanding the pathophysiology of the relevant molecular pathways, but without an ability to robustly link the molecular biology of these pathways to their normal and abnormal role in cognition and behavior.

The premier molecular-genetic methods available in flies, alongside the mature neurophysiological and behavioral approaches, promise to provide deeper insights into how genes, through their effects on cellular and circuit physiology, influence higher brain function and behavior. Thus, flies have the potential to illuminate our basic understanding of cognition alongside paving the way for more rational drug design for mental illness, down the road.

New understandings in cognitive neuroscience are now emerging in Drosophila. Only time will tell the full extent of what we'll learn when all is said and done, but it seems possible that this tiny insect might help to unravel some of the biggest mysteries of the brain. Stay tuned.

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Could Fruit Flies Reveal the Hidden Mechanisms of the Mind? - Scientific American

How can I get my wife to stop her tiresome bragging? – The Oakland Press

Q. My wife's insecurities make her brag when she is around her family. She is a kindhearted and giving person but when her sisters and she get together which is often they get into this tiresome game of one-upmanship. My wife turns into a different person. She shows off and boasts and even tries to drag me into it bragging about things about me that I would rather keep private. I have tried to talk to her about this but she just doesn't see it. I don't know how to handle this anymore.

A. Does she not see she's doing it? Not see how it bothers you? Or maybe not care either way?

At some point, her braggadocio with her sisters, though irritating, veers outside the realm of what you reasonably should have say over (yeah, I can see the "It's none of his business" comments now!). But when it directly involves you, like sharing your information in a way you're not comfortable with, you have a right to be heard.

Focus on that as a concrete example. Don't psychoanalyze her and make it about her "insecurities," but rather explain that you simply don't like feeling like artillery in a war of one-upmanship. "It felt weird for me to be brought into the conversation in that way; I'd really rather be kept out of the fray."

My guess is this dynamic runs decades deep, so it may be tough for you to make headway in helping her change it, especially if she's not on board. You might get more satisfaction finding ways to get your own distance from these brouhahas, logistically and mentally.

Q. I have suffered from panic attacks since I was a child. In college I was put on medication for anxiety, and I am now 27. The medication has helped a bit over the years, but I am hoping to go off of it soon (for many reasons). Is it a bad idea to do this on my own? I know I should probably see a therapist, but I also feel like I could wait and see (money and insurance are an issue) and seek it out if things get bad.

A. No two people with panic attacks are alike just like no two people with vintage brooch obsessions and so I don't want to pretend to know exactly what combination of physiology, environmental conditioning and overall emotional factors make up your particular case. But whoever prescribes the medication should also supervise your coming off it, since there may be things to keep an eye on, depending on the med.

Also, if you've never had cognitive-behavioral therapy (CBT) or acceptance and commitment therapy (ACT) before for your panic attacks or anxiety, you may very well find them helpful. And they could particularly be useful during the transition off the medication. A skilled CBT or ACT therapist who specializes in anxiety and panic treatment can help teach you tools to better manage the panic in the moment in physiological, cognitive and emotional ways.

Some therapists have sliding scales, and some training programs have low-cost therapy. Look around and see what may be possible for you.

Bonior is a licensed clinical psychologist.

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How can I get my wife to stop her tiresome bragging? - The Oakland Press

New findings regarding maintenance and functioning of the endosome – News-Medical.net

On a daily basis, multitudes of molecules enter each cell in our body. These can be nutrients or signal molecules or pathogenic microorganisms. An organelle in the cell directs these molecules to other stations for further processing. This organelle is called the endosome.

If the pathways by which this sorting occurs fails at any stage, several diseases such as neurodegenerative diseases and certain cancers can occur. Thus, a better understanding of the steps in these pathways is of utmost importance.

In a recent study published in Communications Biology, a group of scientists from Japan and Austria, led by Prof Jiro Toshima from the Tokyo University of Science, reports a new finding regarding the maintenance and functioning of the endosome.

Conventional knowledge is that two processes are necessary for the upkeep of endosomes: a) sacs of molecules constantly form at the cell membrane, are transported to the endosome, and fuse into it; b) protein-containing vesicles transported from the Golgi (another cell organelle) fuse with the endosome.

The researchers of this study claim that this is not the case.

They introduce genetic mutations and drugs into yeast cells to inhibit each of these transport processes at a time.

When transport from the Golgi does not occur, a protein essential to the upkeep of the endosome, Rab5, is not activated, and endosome formation is affected. When cell transport from the membrane is inhibited, there is no effect on the endosome.

Thus, essentially, transport from the Golgi is necessary and that from the cell membrane is dispensable, or not as crucial. "Our results provide a different view of endosome formation and identify the Golgi as critical for the optimal maintenance and functioning of endosomes," Prof Toshima says.

This study clarifies only a fraction of the molecule-sorting pathway in cells. But, this is certainly one giant step in the research in this field. Perhaps, the insights from this study will soon appear on the pages of cell biology textbooks.

Source:

Journal reference:

Nagano, M. et al. (2019) Rab5-mediated endosome formation is regulated at the trans-Golgi network. Communications Biology. doi.org/10.1038/s42003-019-0670-5.

Link:
New findings regarding maintenance and functioning of the endosome - News-Medical.net

The Benefits of Molecular Cell Biology – Books LIVE

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The accomplishment by a worldwide group of scientists is significant, not merely due to its sheer size, but also due to the insights it may provide into tissue regeneration. Carbon is possibly the most important element for all living organisms. Every one of these techniques has a particular part to play in allowing scientists to study the critical molecules that form the foundation for life. Opt for an associative chain and receive a hash of its very last block.

Cyclin degradation is needed for the cell to leave the M-phase and most likely the inactivation of p34cdc2. They may be used as enzymes to catalyze certain reactions. This makes a phospholipid. Many nutrient molecules are so big and complex they have to be split homework into smaller molecules before they may be employed by the organism.

If chromosomes arent correctly connected to the spindle apparatus, the metaphase checkpoint will halt the cell cycle. Checkpoint regulation has an important part in an organisms development. 1 chromatid from every pair goes to every daughter cell.

This course is appropriate for company training. By purchasing this product, you agree that youve read and understand the description plus youre aware that you arent purchasing physical book but digital softcopy. This hyperlink to mitosis isnt immediately obvious, this is the kind of question which tests a students ability to work out what is occuring in a particular biological study that they havent seen before. Within this experiment, as in most molecular biology procedures, a control has to be utilized to make sure successful experimentation.

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I think that what look tidal forces generally relativity are really on account of the intrinsic curvature of spacetime. Many physical health conditions also raise the danger of mental disorders. Sometimes, one particular atom will give away electrons to a different atom. Thats the reason why a PoWbased cryptocurrency cannot be economically stable on their nature.

Loaded cardiac hypertrophy will gradually result in a set of cardiovascular diseases. Additionally, the are reliable practices to recognize unique biomarkers and pathological problems. However, once the cancer is discovered to be aggressive, it will most likely spread and, before it does, surgery is the most suitable choice. The very first to recognize nosocomial infections.

Programs concentrate on the use of contemporary technologies in biological research. Bircham University cannot carry out this evaluation without the comprehensive application for admission. Some students might need to take courses during Summer Session to satisfy these requirements.

And on top of that, its totally free! So that was not a truly huge change for me. However, we have to trust on many other techniques when working in a lab. And hes attracted lots of competitive grants for his research. It could help you save you considerable time and, most significantly, safeguard your undertaking.

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The Benefits of Molecular Cell Biology - Books LIVE

Housekeeping secrets of our cells are uncovered by the MRC LMB – Cambridge Independent

Inside our cells, natural housekeeping processes are going on every day.

Proteins required for basic life processes carry out this work across all cell types in the body.

But they require regulation. Like a parent endlessly clearing up after teenagers to prevent too much mess accumulating, our cells tightly control levels of this activity to maintain smooth operation.

The most common way of achieving this is by turning on or off genes in response to the need for the housekeeping protein products they create.

This is accomplished via feedback control of transcription the first step in the process of gene expression, by which information from a gene is used to create a functional product like a protein.

A second method is to degrade messenger RNA (mRNA), which acts as an intermediate carrying instructions in the process of turning a gene into a protein. By stopping these messages, less protein is made.

It was almost 40 years ago that researchers noticed that cells monitor the amount of a group of housekeeping proteins called tubulins and adjust levels of tubulin mRNAs accordingly.

This is called autoregulation, but no factors in the feedback process have previously been identified until now.

In the Cell Biology Division of the MRC Laboratory of Molecular Biology, Manu Hegdes lab has discovered a protein used by cells to find unnecessary mRNA and trigger its destruction.

This is significant not just for our understanding of cellular processes, but also in the fight against disease.

Tubulins are key to the structure and function of neurons, and mutations in tubulin genes cause various neurodevelopmental diseases. Drugs used to treat gout and certain cancer types also target tubulin.

This means that the discovery of a factor regulating tubulin could help lead to new therapeutics for such diseases.

Zhewang Lin in Manus lab searched for factors that selectively engage our cells protein-making factories ribosomes when producing tubulin. He discovered a factor called TTC5 that binds only ribosomes actively making tubulin.

Working with Vish Chandrasekaran, in Venki Ramakrishnans group within the LMBs Structural Studies Division, the structure of TTC5 when bound to a tubulin-producing ribosome was then determined.

They found a groove, within which the beginning of tubulin binds as it emerges from the ribosome like an item being captured as it comes off a factory production line.

Zhewang then made mutations in TTC5, which made them unable to regulate tubulin production rates when excess was present. The factory, in other words, was allowed to go into overdrive.

The work indicated how TTC5 uses the emerging protein as a beacon to find tubulin mRNAs for degradation.

Ivana Gasic in Tim Mitchisons lab at Harvard worked with Zhewang to show that if a working TTC5 is not present, meaning a cell cannot fine-tune its tubulin content, then the alignment and segregation of chromosomes is more prone to errors. They believe this is because tubulin plays a critical role in cell division.

It joins together to form microtubules, which control this key cellular event, along with cell movement and cell shape. Precise control of levels of tubulin is therefore vital.

Further experiments by Zhewang showed that TTC5 is not always available. It is normally sequestered hidden by an inhibitor, which has yet to be identified. It releases TTC5 only under conditions when cells detect too much free tubulin.

The researchers now hope to find this inhibitor and understand how it controls this process of sequestering and releasing TTC5.

Manus lab is also working to identify the machinery responsible for degrading mRNA when requested.

But the mechanism of the nascent protein acting like a beacon to find the tubulin mRNA is important.

Manu told the Cambridge Independent: Our discovery of a central component of the thermostat that regulates the production rate of tubulins allows us to begin understanding how such control systems operate inside the cell. Similar mechanisms are probably used to maintain other important proteins at optimal levels to keep cells healthy.

This work was funded by the MRC, the US National Institutes of Health, the Human Frontier Science Program, the Damon Runyon Cancer Research Foundation, Harvard Medical School, the Vallee Scholars Program, the Wellcome Trust, the Agouron Institute, and the Louis-Jeantet Foundation.

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LMB unveils vision for next generation of Nobel Prize-winning cryo-EM technology

Worlds first synthetic organism with fully recoded DNA is created at MRC LMB in Cambridge

Tributes following the death of Kiyoshi Nagai, of the MRC Laboratory of Molecular Biology

Dr Jan Lwe on the next frontier for MRC Laboratory of Molecular Biology in Cambridge

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Housekeeping secrets of our cells are uncovered by the MRC LMB - Cambridge Independent