The Business Strategies Accepted By Leading Players In The Biochemistry Analyzers Market | (List: Abbott Laboratories,Danaher Corporation and more) -…

The newest research report andinnovative strategies on Biochemistry Analyzers Marketexamined by Marketresearch.biz encloses a comprehensive analysis of the market and was conducted across a variety of industries in various regions to produce more than 100+ page reports. Biochemistry Analyzers concludes with precise and authentic market estimations considering all the parameters and market dynamics. Segmentation of the market is studied specifically to give profound knowledge for supplementary market investments.

Biochemistry Analyzers study is a perfect blend of qualitative and quantifiable information highlighting key market developments, industry, absolute opportunity assessment and competitors challenges in gap analysis and may be trending in the Biochemistry Analyzers market. The strategies followed by leading Biochemistry Analyzers market players which can reflect growth during the forecast period 2020-2029 is analyzed during this report. The past market development, opportunities, and market risks are covered during this study. the elemental Biochemistry Analyzers Market overview, development scope, market dynamics, growth challenges, and influencing factors are briefed.

The Renowned Players-Abbott Laboratories, Danaher Corporation, Hoffman-La Roche Ltd, Meril, Siemens AG, Hologic Inc, Thermo Fisher Scientific Inc, Randox Laboratories Ltd, Beckman Coulter Inc, Horiba Medical

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Biochemistry Analyzers Market Segmentation Overview:

Global biochemistry analyzers market segmentation, by type:

Semi-AutomaticFully AutomaticGlobal biochemistry analyzers market segmentation, by modality:

Bench TopFloor StandingGlobal biochemistry analyzers market segmentation, by end user:

HospitalsDiagnostics CentersAcademic Research InstitutesContract Research OrganizationsPharmaceutical and Biotechnology Companies

The research provides answers to the following key questions:

1) Who are the key Top Competitors in the Global Biochemistry Analyzers Market?

Following are the list of key players: Abbott Laboratories, Danaher Corporation, Hoffman-La Roche Ltd, Meril, Siemens AG, Hologic Inc, Thermo Fisher Scientific Inc, Randox Laboratories Ltd, Beckman Coulter Inc, Horiba Medical

2) What is the expected market size and growth rate of the Biochemistry Analyzers market for the period 2020-2029?

** The Values marked with XX is confidential data. To know more about CAGR figures fill in your information so that our business development executive can get in touch with you.

3) Which Are The Main Key Regions Cover in Reports?

Geographically, this report is segmented into several key Regions, consumption, revenue (million USD), and market share and growth rate of Biochemistry Analyzers in these regions, from 2020 to 2029 (forecast), covering North America, Europe, Asia-Pacific, etc

4) Can I include additional segmentation/market segmentation?

Yes. Additional granularity/market segmentation may be included depending on data availability and the difficulty of the survey. However, you should investigate and share detailed requirements before final confirmation to the customer.

Global Biochemistry Analyzers Market Research Report comprises holistic business information and changing trends in the current market that enables users to spot the pin-point analysis of the market along with growth, revenue and profit during the forecast period 2020-2029. It provides an in-depth study of Biochemistry Analyzers Market by using SWOT analysis. This gives a complete analysis of drivers, restraints, and opportunities of the market. Additionally, the report provides a detailed study of top players within the market by highlighting their product description, business overview, and business strategy. It also endows with a quantity of production, required raw material, future demand, and the money health of the organization.

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Biochemistry Analyzers market research report also involves the manufacturing process along with shipment, price, interview records, gross profit, potential, revenue, business distribution, etc. This enables users to get a complete scenario of competitive analysis of the market.

Also, Biochemistry Analyzers survey report offers Porters Five Forces analysis and PESTLE analysis for more detailed contrast studies. Each section of the report has something valuable that helps companies for improving their sales and marketing strategy, gross margin, and profit margins. Using the report as a tool for gaining insightful Biochemistry Analyzers market analysis, players can identify the much-required changes in their operation and improve their approach to doing business.

In this study, the years considered to estimate the market size of the Biochemistry Analyzers are as follows:

Base Year: 2019 | Estimated Year:2020 | Forecast Year: 2020 to 2029

Table of Content:

Market Outline:The report lists the merchandise overview, applications, product highlights including price, revenue, sales, rate of growth, and market share study.

Competition by Top Players:Worldwide market players and their Biochemistry Analyzers competition by the newest trends, market share, expansion, sales, and acquisitions are stated.

Business Profiles and Sales Analysis:This section stated the sales analysis of top Biochemistry Analyzers Market, manufacturing base, top regions, specifications, and merchandise details are stated.

Market Position and Regional Level View:during this part, the report states the CAGR value, market size estimation by regions and top countries present in North America, Europe, Asia-Pacific, Middle East, and Africa and South America.

Application or user Segment Analysis:This part explains the wide selection of applications that contribute to Biochemistry Analyzers marketing research

Forecast Trend Analysis:Here, the report states forecast Biochemistry Analyzers Industry view and revenue estimates for various segments like product, types, and applications for the forecast period from 2020-2029.

Research Outcomes and Inference:This part of the report mentions the analyst opinions and findings of Biochemistry Analyzers Market.

Appendix Section:Here, weve stated the disclaimer, data sources, research methodology, data triangulation, market breakdown.

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Definitively, Biochemistry Analyzers report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

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The Business Strategies Accepted By Leading Players In The Biochemistry Analyzers Market | (List: Abbott Laboratories,Danaher Corporation and more) -...

Astrobiologist explains why there may be invisible aliens among us. – Tech Ballad

Life is pretty easy to learn. He moves, he grows, he eats, he secrete, he multiplies. Simply. In biology, researchers often use the abbreviation MRSGREN to describe it. It refers to movement, breathing, sensitivity, growth, reproduction, excretion and nutrition.

But Helen Sharman, the first British astronaut and chemist at Imperial College London, recently said that alien life forms that cannot be found can live among us. How could this be possible?

Although life can be easily recognized, it is actually difficult to define, and scientists and philosophers have argued for centuries, if not millennia. For example, a 3D printer can reproduce itself, but we would not call it alive. On the other hand, the mule is famously sterile, but we would never say that he does not live.

As no one can agree, there are over 100 definitions of what life is. An alternative (but imperfect) approach describes life as a self-sustaining chemical system capable of Darwin evolution, which works in many of the cases that we want to describe.

(Read: aliens exist, but we are not open enough to see them)

Lack of definition is a huge problem when it comes to finding life in space. Failure to define life other than we will know it when we see it means that we really confine ourselves to geocentric, perhaps even anthropocentric ideas about how life looks. When we think of aliens, we often portray humanoid creatures. But the intelligent life we seek does not have to be humanoid.

Sharman says that she believes that aliens exist, and there are no two ways. She also wonders: Will they look like you and me, made up of carbon and nitrogen? Probably no. Perhaps they are here now, and we simply cannot see them.

Such a life will exist in the shadow biosphere. By this I do not mean the realm of ghosts, but undetected creatures, possibly with a different biochemistry. This means that we cannot study or even notice them, because they are beyond our comprehension. Assuming that it exists, such a shadow biosphere is likely to be microscopic.

So why didnt we find it? We have limited opportunities to study the microscopic world, since only a small percentage of microbes can be cultured in the laboratory. This may mean that there really can be many life forms that we have not yet noticed. Now we have the opportunity to sequence the DNA of uncultured strains of microbes, but this can only be detected by the life that we know which contains DNA.

However, if we find such a biosphere, it is not clear whether we should call it a stranger. It depends on whether we mean extraterrestrial origin or simply unfamiliar.

A popular alternative biochemistry proposal is based on silicon, not carbon. This makes sense even from a geocentric point of view. About 90 percent of the Earth is made up of silicon, iron, magnesium and oxygen, which means there are many opportunities for creating potential life.

Artists impression of silicone life form. Zita

Silicon is like carbon, it has 4 electrons to create bonds with other atoms. But silicon is heavier, with 14 protons (protons make up the atomic nucleus with neutrons) compared with six in the carbon nucleus. Although carbon can create strong double and triple bonds to form long chains, useful for many functions, such as building cell walls, silicon is much more complex. He is struggling to create strong bonds, so molecules with long chains are much less stable.

Moreover, conventional silicon compounds, such as silicon dioxide (or silicon dioxide), are usually solid at terrestrial temperatures and insoluble in water. Compare this, for example, with highly soluble carbon dioxide, and we will see that carbon is more flexible and provides much more molecular possibilities.

Life on Earth is fundamentally different from the basic composition of the Earth. Another argument against the silicon-based shadow biosphere is that there is too much silicon in the rocks. In fact, the chemical composition of life on Earth has an approximate correlation with the chemical composition of the Sun, with 98 percent of the atoms in biology being made up of hydrogen, oxygen, and carbon. So, if there were viable life forms of silicon, they could have developed elsewhere.

However, there are arguments in favor of silicon-based life on Earth. Nature is adaptable. A few years ago, scientists at the California Institute of Technology managed to bring out a bacterial protein that created bonds with silicon essentially driving silicon. Thus, although silicon is inflexible compared to carbon, it may be able to find ways to assemble into living organisms, potentially including carbon.

And when it comes to other places in space, such as the moon of Saturns Titan or planets orbiting other stars, we certainly cannot rule out the possibility of life based on silicon.

To find it, we must somehow think outside the framework of terrestrial biology and find ways to recognize life forms that are fundamentally different from carbon-based forms. There are many experiments to test these alternative biochemical methods, for example, from Caltech

Regardless of the belief of many that life exists elsewhere in the universe, we have no evidence of this. Therefore, it is important to consider all life as precious, regardless of its size, quantity or location. Earth supports the only known life in the universe. Therefore, no matter what form life can take elsewhere in the solar system or the universe, we must be sure that we will protect it from harmful pollution whether it be earthly life or alien life forms.

So can aliens be among us? I do not believe that we were visited by a living form with the technology to travel through vast outer spaces. But we have evidence that carbon-based life-forming molecules arrived on Earth on meteorites, so the data certainly does not preclude the same possibility for more unfamiliar life forms.

This article is reprinted from Conversation by Samantha Rolfe, lecturer in astrobiology and chief technical specialist at the Bayfordbury Observatory, University of Hertfordshire, licensed under Creative Commons. Read the original article.

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Astrobiologist explains why there may be invisible aliens among us. - Tech Ballad

What’s on Your Shelf? Recommended Reading in the New Year – Healio

Over the past few years in this column, I have occasionally shouted out a book I have read and I have occasionally been rewarded by more than a few of my readers then sharing with me their thoughts and experiences of these same works. As the first editorial of 2020, I thought it might be fun to go to my bookshelf and share a number of the titles I have read over the past year.

I always read both nonfiction and fiction at the same time, but I am only going to give you my nonfiction picks. To get my fiction reading list, you will have to buy me a glass of wine so I can wave my hands and tell you why I picked certain books. A second caveat is that I must be truthful and tell you that I often buy the Kindle version of a nonfiction book first, and if I really like it, then I buy the real deal because I like to write and scribble in my books. I am not sure what that says about me but thats the way it is and virtually all have come into my passion this way.

Leonard H.Calabrese

There is no total unifying theme of the nine books I am recommending to you but, after looking at this stack, I think I found a few threads. My intention in this column is to give you enough information that will tempt you to pick one or more up on the basis of our shared interests. The first theme surrounds my work, namely the field of immunology in all its glory. There are three books that deal with my field and thus one may wonder what there could be in books written for the lay public that would make heart a card-carrying immunology guys heart sing to read? The answer is easy. Its all about the humanity.

In An Elegant Defense, Matt Richtel recounts stories of real patients with HIV, rheumatoid arthritis, and cancer intersecting with therapeutic advances in the field, and the enormous impact these changes have had on them. In The Breakthrough, Charles Graeber details the backstory of the people behind the development of checkpoint inhibitors, including many colorful interviews with Nobel Laureate James P. Allison, PhD even for me, actively working in the field, this was a terrific read.

Finally, the real sleeper in the immunology cassette, is The Beautiful Cure by Daniel M. Davis, which despite not garnering the press it deserves, in my opinion is a brilliant treatise on the evolution of the field of immunology over the past century. The book is written in scholarly fashion, but laced with terrific backstories in the style of The Gene by Siddhartha Mukherjee. Read it!

Switching gears, The Compassionate Connection by David Rakel and Suggestible You by Eric Vance are all about placebo science and the role of interpersonal relationships in building wellness and healing. Both of these are great reads and I am planning on a cover story/roundtable in the spring on placebo science in rheumatology. See how this works now?

The Longevity Diet by Valter Longo, PhD, a leading researcher in aging/longevity research is a terrific read on something we all share an interest in namely how to eat and living a long life. I find choosing books in the wellness field often problematic given the myriad of bugnutty offerings out there, but I assure you, Dr. Longo is a scientist in the truest sense of the word. I recently hosted him at my 2019 Cleveland Clinic Biologic Therapies VIII Summit, a presentation you will be able to watch when it posts on our website in the near future.

In my previous editorials in February 2019 and April 2019, I have already discussed the profound impact of The Empathy Effect by Helen Reiss, MD, and Deep Medicine by Eric Topol, MD, so I will not expound on them again if you havent picked up by now, please do. Perhaps counterintuitively, I believe these books on empathy and artificial intelligence are intimately related. As I have written in the past, one of the most exciting and challenging areas of investigation lying ahead is how to bring empathy to the growing onslaught of AI, machine learning and technology. We must figure this out.

Finally, why did Leonardo Da Vinci, by the noted biographer Walter Isaacson, make it to my bedside reading table? There are many reasons, perhaps prominent among them that 2019 was the 500th anniversary of the death of the most curious man with the greatest mind the world has ever known. Probably more important is a passion to learn about him instilled by a friend and a physician, humanist and Da Vinci scholar, Sal Mangione, MD, from Thomas Jefferson University.

I have heard Dr. Mangione speak on Da Vinci many times, and he has also graced our Medical Grand Rounds podium frequently discussing art, observation and humanism. His passion for the life, work and genius of Leonardo Da Vinci is quite infectious, and the book is a great start to understanding the master Thank you Sal, I am hooked.

These are my nonfiction picks from the last year tell me about yours through Twitter at @LCalabreseDO or email me at calabrl@ccf.org.

Disclosures: Calabrese reports consulting relationships with AbbVie, Centecor Biopharmaceutical, Crescendo Bioscience, GlaxoSmithKline, Horizon Pharma, Janssen Pharmaceuticals, Pfizer, Regeneron Pharmaceuticals and UCB.

Over the past few years in this column, I have occasionally shouted out a book I have read and I have occasionally been rewarded by more than a few of my readers then sharing with me their thoughts and experiences of these same works. As the first editorial of 2020, I thought it might be fun to go to my bookshelf and share a number of the titles I have read over the past year.

I always read both nonfiction and fiction at the same time, but I am only going to give you my nonfiction picks. To get my fiction reading list, you will have to buy me a glass of wine so I can wave my hands and tell you why I picked certain books. A second caveat is that I must be truthful and tell you that I often buy the Kindle version of a nonfiction book first, and if I really like it, then I buy the real deal because I like to write and scribble in my books. I am not sure what that says about me but thats the way it is and virtually all have come into my passion this way.

Leonard H.Calabrese

There is no total unifying theme of the nine books I am recommending to you but, after looking at this stack, I think I found a few threads. My intention in this column is to give you enough information that will tempt you to pick one or more up on the basis of our shared interests. The first theme surrounds my work, namely the field of immunology in all its glory. There are three books that deal with my field and thus one may wonder what there could be in books written for the lay public that would make heart a card-carrying immunology guys heart sing to read? The answer is easy. Its all about the humanity.

In An Elegant Defense, Matt Richtel recounts stories of real patients with HIV, rheumatoid arthritis, and cancer intersecting with therapeutic advances in the field, and the enormous impact these changes have had on them. In The Breakthrough, Charles Graeber details the backstory of the people behind the development of checkpoint inhibitors, including many colorful interviews with Nobel Laureate James P. Allison, PhD even for me, actively working in the field, this was a terrific read.

Finally, the real sleeper in the immunology cassette, is The Beautiful Cure by Daniel M. Davis, which despite not garnering the press it deserves, in my opinion is a brilliant treatise on the evolution of the field of immunology over the past century. The book is written in scholarly fashion, but laced with terrific backstories in the style of The Gene by Siddhartha Mukherjee. Read it!

Switching gears, The Compassionate Connection by David Rakel and Suggestible You by Eric Vance are all about placebo science and the role of interpersonal relationships in building wellness and healing. Both of these are great reads and I am planning on a cover story/roundtable in the spring on placebo science in rheumatology. See how this works now?

The Longevity Diet by Valter Longo, PhD, a leading researcher in aging/longevity research is a terrific read on something we all share an interest in namely how to eat and living a long life. I find choosing books in the wellness field often problematic given the myriad of bugnutty offerings out there, but I assure you, Dr. Longo is a scientist in the truest sense of the word. I recently hosted him at my 2019 Cleveland Clinic Biologic Therapies VIII Summit, a presentation you will be able to watch when it posts on our website in the near future.

PAGE BREAK

In my previous editorials in February 2019 and April 2019, I have already discussed the profound impact of The Empathy Effect by Helen Reiss, MD, and Deep Medicine by Eric Topol, MD, so I will not expound on them again if you havent picked up by now, please do. Perhaps counterintuitively, I believe these books on empathy and artificial intelligence are intimately related. As I have written in the past, one of the most exciting and challenging areas of investigation lying ahead is how to bring empathy to the growing onslaught of AI, machine learning and technology. We must figure this out.

Finally, why did Leonardo Da Vinci, by the noted biographer Walter Isaacson, make it to my bedside reading table? There are many reasons, perhaps prominent among them that 2019 was the 500th anniversary of the death of the most curious man with the greatest mind the world has ever known. Probably more important is a passion to learn about him instilled by a friend and a physician, humanist and Da Vinci scholar, Sal Mangione, MD, from Thomas Jefferson University.

I have heard Dr. Mangione speak on Da Vinci many times, and he has also graced our Medical Grand Rounds podium frequently discussing art, observation and humanism. His passion for the life, work and genius of Leonardo Da Vinci is quite infectious, and the book is a great start to understanding the master Thank you Sal, I am hooked.

These are my nonfiction picks from the last year tell me about yours through Twitter at @LCalabreseDO or email me at calabrl@ccf.org.

Disclosures: Calabrese reports consulting relationships with AbbVie, Centecor Biopharmaceutical, Crescendo Bioscience, GlaxoSmithKline, Horizon Pharma, Janssen Pharmaceuticals, Pfizer, Regeneron Pharmaceuticals and UCB.

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What's on Your Shelf? Recommended Reading in the New Year - Healio

Hope for patients with a rare genetic condition linked to severe infections – Newswise

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Journal of Allergy and Clinical Immunology, January 2020

Newswise A team of researchers at CHU Sainte-Justine and Universit de Montral has shed light on the mechanisms that underlie a rare genetic condition by creating the first cellular model of the disease. The study's findings were published today in the Journal of Allergy and Clinical Immunology.

Chronic granulomatous disease (CGD) is a rare hereditary condition that affects one in every 217,000 people worldwide and typically strikes patients at an early age.

It is a primary innate immune defect that typically leads to severe, recurrent infections caused by bacteria and fungi, as well as potentially disabling lung inflammation or inflammatory colitis similar to Crohns disease, said senior author Dr.FabienTouzot, a clinical assistant professor in pediatric medicine at UdeM and researcher in pediatric immunology and hematology at CHU Sainte-Justine.

Currently, patients are forced to take antibiotics and anti-inflammatory drugs for the rest of their lives.

Gene editing shows the way forward

To better understand the mechanisms that trigger inflammation in patients with CGD, Touzot and his research team created the very first cellular model of the disease in their labs at CHU Sainte-Justine. They then used a technique known as gene editing to recreate and introduce into their model a genetic mutation that causes the disease. This allowed them to model the inflammatory response observed in patients and to study its mechanisms.

CGD is a hereditary illness caused by mutations in the NADPH oxidase enzyme. These mutations prevent white blood cells from working properly and, as a result, the patients body can no longer defend itself against certain kinds of bacteria and fungi, said researcher Aissa Benyoucef, the studys first author.

More than 90% of affected patients have inflammation that appears to be unrelated to infectious agents," he added. "Treating this inflammation is difficult, since it can put patients at increased risk of infection, which can sometimes be fatal. A better understanding of the mechanisms underlying the disease could help us develop new and more effective treatment strategies.

The research team showed that restoring NADPH oxydase function in defective cells would put the immune process back on track, thereby proving that this genetic mutation plays a direct role in causing inflammation.

CHU Sainte-Justine is one of Quebecs leading centres of expertise in rare genetic diseases," said Touzot. "Were proud to serve patients by expanding the knowledge base in this area and by contributing to the development of precision medicine."

The new cellular model will be useful for the development of targeted treatments that are less toxic and more effective in treating inflammation, significantly improving patient quality of life, according to the researchers.

About this study

CRISPR gene-engineered CYBBko THP-1 cell lines highlight the crucial role of NADPH-induced reactive oxygen species for regulating inflammasome activation was published in the January 2020 edition of the Journal of Allergy and Clinical Immunology. The first author is Aissa Benyoucef, PhD, a lab employee under the supervision of Dr. Fabien Touzot. The senior author is Dr. Touzot, MD, PhD, a clinical assistant professor at Universit de Montreals Department of Pediatrics and clinician-researcher in pediatric immunology and hematology at CHU Sainte-Justine. The study was paid by a CHU Sainte-Justine Research Centre start-up fund and by Fondation Charles-Bruneau.

About the CHU Sainte-Justine Research Centre

The CHU Saint-Justine Research Centre is a flagship institution in mother-child research affiliated with Universit de Montral. Focused on the discovery of innovative means of prevention, less intrusive and faster treatments and promising avenues of personalized medicine, it brings together more than 210 researchers, including more than 90 clinical researchers, as well as 450 graduate students and postdoctoral fellows. The centre is an integral part of the Centre hospitalier universitaire Sainte-Justine, the largest mother-child centre in Canada. Details at https://research.chusj.org/en/Home

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Hope for patients with a rare genetic condition linked to severe infections - Newswise

Cancer immune cell: what have scientists discovered? – The Week UK

The discovery of a killer cell in the human immune system could lead to a one-size-fits-all cancer treatment, according to a newly published study.

The team of Cardiff University researchers who made the find say the T-cell has already been used in lab tests to attack and destroyprostate, breast, lung and other cancer cells.

Although no tests have been conducted yet on human patients, scientists say the findings - outlined in a newly publishedpaperin the journal Nature Immunology -haveenormous potential, the BBC reports.

One of the most groundbreaking advances in the fight against cancer in recent years is a treatment known as CAR-T immunotherapy. This therapy involves harvesting a patients immune T-cells and reprogramming them to target specific proteins found on the patients cancer cells, while leaving healthy cells undamaged, explains science news siteNew Atlas.

However, a major limitation facing researchers of CAR-T therapies has been the lack of a universal T-cell receptor (TCR) that can target different kinds of cancers in all patients.

But the T-cell discovered by the Welsh university team appears to be equipped with a new type of TCR that does exactly that.

This T-cell recognises a molecule present on the surface of a wide range of cancer cells, and normal cells, and is able to distinguish between healthy and cancerous cells - killing only the latter, The Independentreports.

In lab tests on mice and human cells, the T-cells equipped with the new TCR has been found to kill lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells.

If these sorts of effects can be replicated in humans,says ScienceAlert, we could be looking at a bright new future for T-cell treatments.

According to Wales Online, experiments are under way to determine the precise molecular mechanism by which the new TCR distinguishes between healthy cells and cancer, and researchers hope to begin human patients towards the end of this year following further safety testing.

Cardiff University professor Awen Gallimore, a cancer immunology lead for the Wales Cancer Research Centre, said: If this transformative new finding holds up, it will lay the foundation for a universal T-cell medicine, mitigating against the tremendous costs associated with the identification, generation and manufacture of personalised T-cells.

This is truly exciting and potentially a great step forward for the accessibility of cancer immunotherapy.

Alasdair Rankin of blood cancer charity Bloodwise added: This research represents a new way of targeting cancer cells that is really quite exciting, although much more research is needed to understand precisely how it works.

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Cancer immune cell: what have scientists discovered? - The Week UK

Hairy cells in the nose called brush cells may be involved in causing allergies – Science News

Some hairy cells in the nose may triggersneezing and allergies to dust mites, mold and other substances, new work withmice suggests.

When exposed to allergens, these brushcells make chemicals that lead to inflammation, researchers report January17 in Science Immunology. Only immunecells previously were thought to make such inflammatory chemicals fattycompounds known as lipids. The findings may provide new clues about how peopledevelop allergies.

Brush cells are shaped like teardropstopped by tufts of hairlike projections. In people, mice and other animals, thesecells are also found in the linings of the trachea and the intestines, wherethey are known as tuftcells (SN: 4/13/18). However, brushcells are far more common in the nose than in other tissues, and may help thebody identify when pathogens or noxious chemicals have been inhaled, says LoraBankova, an allergist and immunologist at Brigham and Womens Hospital inBoston.

Bankova and her colleagues discoveredthat, when exposed to certain molds or dust mite proteins, brush cells inmices noses churn out inflammation-producing lipids, called cysteinylleukotrienes. The cells also made the lipids when encountering ATP, a chemical usedby cells for energy that also signals when nearby cells are damaged, as in aninfection. Mice exposed to allergens or ATP developed swelling of their nasaltissues. But mice that lacked brush cells suffered much less inflammation.

Such inflammation may lead to allergiesin some cases. The researchers havent yet confirmed that brush cells in humannoses respond to allergens in the same way as these cells do in mice.

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Hairy cells in the nose called brush cells may be involved in causing allergies - Science News

New breakthrough discovery in immune system could treat all types of cancer – News Heads

New Delhi : A newly-discovered part of our immune system can be used to save and cure you from all types of cancers, say scientists.

A team of Cardiff University scientists discovered have discovered a method to kill prostate, breast, lung and other cancers in lab tests.

The findings from their study have been published in Nature Immunology. However, the procedure is yet to be tested on a patient, the scientists are positive and have a strong belief that this will turn in their favour.

Progress till date

Human body has its natural defence to the diseases, commonly known as immune system. The scientists were looking for "unconventional" and previously undiscovered ways the immune system naturally attacks tumours.

During the research, they found that T-cell inside human blood that keeps a check on the body to locate which part of the body has a threat to the disease and needs to be eliminated.

The difference is this one could attack a wide range of cancers.

"There's a chance here to treat every patient," researcher Prof Andrew Sewell told the BBC.

He added: "Previously nobody believed this could be possible.

"It raises the prospect of a 'one-size-fits-all' cancer treatment, a single type of T-cell that could be capable of destroying many different types of cancers across the population."

How does T-Cell work?

T-cells have "receptors" on their surface that allow them to "see" at a chemical level.

The Cardiff team discovered a T-cell and its receptor that could find and kill a wide range of cancerous cells in the lab including lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells.

Crucially, it left normal tissues untouched.

How would the treatment be done?

According to the scientists, a blood sample would be taken from the patient to locate T Cells then they will be genetically modified and placed back in the blood and then into the human body.

The new modified T cells will no locate the cancer-causing threats and would eliminate them automatically without causing any damage to other parts of our body.

Expert Researchers Reaction to the study

Lucia Mori and Gennaro De Libero, from the University of Basel in Switzerland, said the research had "great potential" but was at too early a stage to say it would work in all cancers.

"We are very excited about the immunological functions of this new T-cell population and the potential use of their TCRs in tumour cell therapy," they said.

Daniel Davis, a professor of immunology at the University of Manchester, said: "At the moment, this is very basic research and not close to actual medicines for patients.

"There is no question that it's a very exciting discovery, both for advancing our basic knowledge about the immune system and for the possibility of future new medicines."

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New breakthrough discovery in immune system could treat all types of cancer - News Heads

Kaitlin Walsh: Anatomy of the Senses, February 1 through 28 – River Cities Reader

Exhibit: Saturday, February 1, through Friday, February 28Opening Reception: Friday, February 7, 5:30 7:30 p.m.Berskin Gallery & Art Academy, 2967 State Street, Bettendorf IA

A celebration of the human body's most fascinating facets as viewed through abstract illustrations will grace the Berskin Gallery & Art Academy from February 1 through 28, with the Bettendorf venue hosting colorful, captivating works by Bettendorf artist Kaitlin Walsh in her new exhibition Anatomy of the Senses.

An independent artist specializing in abstract anatomy watercolor and oil paintings, Walsh, from a young age, exhibited an immense fascination with both art and science. She focused her studies on both disciplines, taking medical courses alongside fine art ones, and this culminated with a graduate degree in Biomedical Visualization at the University of Illinois at Chicago. Soon after graduation, Walsh married and had her first child, a son who spent several months in the hospital recovering from prenatal complications and an early birth. This experience motivated the artist to focus her career on her passion: portraying the beauty and complexity of the human body, as her sons initially precarious health status, while frightening, also compelled her to appreciate the things that were going well within his body.

Walsh was naturally impelled to convey this appreciation through her paintings, using the skills gained throughout her education. After spending some time honing her craft, increasing her inventory, and having more children, she opened up shop, saying, I feel incredibly lucky to have found success doing what I love. She is currently in the top 1 percent of Etsy sellers and has sold over 15,000 prints of her anatomical fine art paintings, and lives happily in Bettendorf with her husband and three healthy children. Kaitlin joined Berskin Gallery & Art Academy in December, says gallery owner Pat Berskin, adding, We are delighted to announce that she will begin teaching abstract watercolor in the spring. Her work is not only inspiring, but educational and aesthetically pleasing. Her positive energy and enthusiasm for the arts made for an excellent match with our programs.

A 5:30 p.m. opening reception will be held at the Berskin Gallery & Art Academy on February 7, and regular gallery hours are 11 a.m. to 6 p.m. on Wednesdays through Saturdays. Admission is free, and more information on the February 1 through 28 Kaitlin Walsh: Anatomy of the Senses exhibition is available by calling (563)508-4630 or visiting BereskinArtGallery.com.

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Kaitlin Walsh: Anatomy of the Senses, February 1 through 28 - River Cities Reader

Anatomy of a one-on-one steal: is this how we want the game to look? – NRL.COM

A rule tweak at the end of 2017 allowing one-on-one steals to be executed in multi-tackler tackles provided only one defender was involved at the time of the strip saw the tactic proliferate last season.

As we head into the third season of the new rule interpretation, NRL.com Stats has taken a look at how the practice has evolved, how it may evolve further and what implications that may hold.

After little change in 2018, the first year of the new interpretation, one-on-one strips proliferated in 2019.

The Raiders in particular and also the Storm got better at surprising teams by using secret code-words to co-ordinate for extra tacklers to drop off, leaving one man to effect a steal before the ball-carrier realised he was in danger of losing possession.

There were 120 successful steals through the 201 NRL matches in 2019. That is up from 68 in 2018 when the rule was first changed (the Raiders again were top with 11), and 44 in 2017 under the old rule.

The Raiders (28), Storm (19) and Warriors (11) were the only clubs to hit double digits in 2019. Josh Hodgson (14) individually effected more than 14 other clubs.

Teams were generally good at ensuring they didn't infringe once they decided to attempt a steal there were 25 penalties for stealing the ball where it was deemed there was more than one in the tackle.

There were a further 232 penalties for a stripping action however these are the ones where the ball pops free in a tackle and it is deemed a defender hit or raked at the ball so there is no deliberate stealing action.

For the most part the officials did a remarkably good job of deducing in a split second at what point the extra tacklers dropped off and at what point the ball came free.

With the practice likely to increase further in 2020 as teams aim to emulate the Raiders' success, things won't get easier for the officials.

The officials have to make the calls in real time (unless there is a rare instance of the steal directly leading to a try) so they do not have the benefit of video replays.

They didn't always get it right; for example frustrated Warriors coach Stephen Kearney lashed out after a couple of tight calls incorrectly went against his side in a 24-22 loss to the Eels in round 19. "If they can't get it right just piss it off," Kearney fired.

Roosters coach Trent Robinson and, perhaps surprisingly, Raider coach Ricky Stuart have publicly criticised the rule.

Robinson believes it is not in the spirit of the game and says his team will not be coached to do it (the Roosters registered just three steals in 2019) while Stuart suggested referees were being forced to guess when the extra tacklers drop off.

The reception has been largely positive from fans on both social media and in official fan surveys.

For the most part fans appreciated the unpredictability and the chance for momentum swings in a game where possession is at a premium and can be hard to claw back once the tide turns against a team.

The NRL's head of football elite competitions Graham Annesley touched on issues around the rule during his weekly briefings several times and, while admitting it placed extra pressure on referees, broadly supported the positive reception around the increase in unpredictability and renewed contest for possession.

One of the looming issues for the rule in 2020 is what actually constitutes "one-on-one". NRL.com Stats has isolated a number of incidents from 2019 where a ball-carrier was effectively gang-tackled, with defenders wrapping up his legs and non-ball-carrying arm while another defender started prising the ball out.

The extra defenders drop off with the steal largely effected already.

So while defenders of the new rule say "if you hang onto the ball you won't have a problem" that doesn't always hold true, as the attached examples highlight.

Some have expressed concern coaches may become so worried about having the ball ripped away, players would be instructed to wrap it up tightly in carries and put the offloads away. There has been no evidence of this yet but 2020 could be the acid test if more clubs work on the strategy.

NRL.com Stats has collated some examples that most clearly highlight the issue in the above video and still shots. Each was deemed a legal strip at the time, and resulted in the team executing the strip gaining possession.

These selected examples are at the more extreme end of a ball carrier being wrestled by one or more defenders while also being stripped by another. However, they do not represent the majority of instances of one-on-one strips.

In all, there were 120 steals in 2019, from 201 total games, at a rate of slightly over one steal for every two games.

Of those 120, some would have been legal one-on-one steals even under the old interpretation and in many more the stripping action largely occurs in a one-on-one scenario despite earlier involvement from an extra tackler or tacklers.

Less than a quarter which would equate to roughly one instance per round of eight games bears similarity to the attached examples.

So, at this stage, there is no epidemic of messy gang-tackle steals. However as we have seen with countless previous rules and interpretations, coaches are smart. Their concern is winning games. If they sense a chance to earn an advantage, they will explore it.

Will we see more cases like these examples in 2020? If so that would test the interpretation. If the above examples become more common that could have a detrimental effect on the game as a spectacle and raise questions about fairness.

How the Perth NRL Nines will work

The details are still being worked out but a challenge system will be in play in 2020.

A by-product of this is for the potential for steals to be adjudicated on by the Bunker with slow-motion replays rather than by on-ground officials on the fly.

If a captain believes his player has been unfairly stripped but play has been allowed to continue, he will be able to send that play to the Bunker.

This in turn could force some clarity around what happens in situations like those outlined above.

The reworded rule concerning stealing the ball is as follows:

a. The ball can be stolen from the player in possession at any stage prior to a tackle being complete when there is only one defender effecting the tackle;

b. If there are two or more defender[s] effecting the tackle and the ball is stolen a penalty should be awarded, except if the player in possession is attempting to ground the ball for a try.

So when it comes to a grey area where the ball is partway out while more than one player is still involved, it comes down to the referee's interpretation as so many other grey areas do.

Think forward passes that look backwards out of the hand but float forward, or when a player loses control in a play-the-ball while being crowded by a tackler. This is what could be tested by the Bunker this season.

The rule is certainly here to stay for 2020 at least the competition committee have already decided on rule changes for 2020 and the stripping law will stay as-is for at least this year.

Continued here:
Anatomy of a one-on-one steal: is this how we want the game to look? - NRL.COM

Anatomy of an Ad: the story behind Greenpeace’s harrowing tale of turtle extinction – The Drum

Following the impact of its Rang-tan palm oil campaign, last week Aardman and Greenpeace unveiled 'Turtle Journey' - a heart-wrenching stop motion animation that worked to urge people to take action on the ocean crisis.

The campaign brought together the activist strength of Greenpeace with the famed creative of Aardman Animations, the makers of Wallace and Gromit and famous voices like Olivia Colman, Dame Helen Mirren and Stranger Things' David Harbour.

The Drum went behind the scenes to uncover how the major project came together.

A major focus for Greenpeace has been bringing the problems facing the worlds oceans as a result of climate change into public awareness. Back in 2018, what started as a Twitter joke, resulted in Stranger Things David Harbour dancing with penguins in the Antarctic to raise awareness of their plight.

That same year, Radiohead lead singer and environmental activist, Thom Yorke, released a single in support of Greenpeaces mission to protect the Antarctic Ocean from the effects of climate change, commercial fishing, and human interference. The ominous instrumental tracks message was relayed on Londons Marble Arch.

Meanwhile, to celebrate World Oceans Day in 2018, people from 25 countries and all seven continents painted themselves blue and perform human waves to show their support for ocean protection.

Happy World Oceans Day! Together, we're campaigning for an ocean rescue plan that'd create huge new ocean sanctuaries all over the world. If it...

But despite all the action Greenpeace has taken to drive this message home, Chris Till, deputy fundraising director at Greenpeace admitted its not been as effective as it would like.

"If you spoke to most people, they would have no idea that the United Nations (UN) is in the middle of negotiating a big new global ocean treaty, he said. Despite the fact that that could arguably affect the future of life on earth.

The Greenpeace team realised they needed to do something that would help it break out of its bubble of support, and get its message out into the wider world.

Ahead of the UN global ocean treaty talks in March, Greenpeace wanted to take plan to action by launching a petition to ensure the treaty came to life.

Greenpeace was also battling against peoples resistance to shocking footage. For decades, bodies like Comic Relief and Children in Need have relied on distressing footage to spur people into giving. But recent reports claim hearts are hardening against distressing content.

In preparing for this campaign, Greenpeace quickly came to the conclusion that emotional animations would be a more effective tactic.

As a society, were fast getting used to images that used to be shocking, admitted Till. Animation can be different as it allows people to emotionally connect. They can see themselves within the story in a way thats difficult to do in the real world.

The team had also learned a lesson from its wildly successful Rang-tan campaign; Greenpeaces emotional tale starring actress Emma Thompson that hit home the hard reality of palm oil, and the effect its cultivation has on the earth.

With help from Iceland, which chose to repurpose the video for its Christmas ad, the film thrust the issue of palm oil into the popular mindset. This, in turn, encouraged more people to consider it when buying food and products.

"It really pushed it into the public spotlight," explained Till. "And we knew we needed to do something similar with our next campaign, to get people really talking and taking action about the ocean crisis."

Fortuitously, around the time Greenpeace was mapping out this campaign Aardman Animation got in touch to say it was interested in working with the organisation.

It just felt like a perfect fit, Till said. We were looking for something that would make a strong connection with our audience and Aardman is brilliant at that. As we're both household names in our own right, it would help get the word out.

Following market testing around wider communication for the oceans issue, the research persuaded the team decided to focus on turtles. Till argued that while Greenpeace has a strong track record of talking about whales, they are received differently across the world. Turtles, on the other hand, have universal appeal.

The team at Greenpeace then spoke to Aardmans producers on what they wanted to get out of the film, the reaction they wanted and soon they began working on a brief.

This was then used to reach out to Aardmans network of directors, which garnered 12 pitches as to what this film could look like. They were brilliant and varied and offered many different ways of tackling what could be a very difficult subject, Till said.

We were clear that we wanted the animation to be immediately recognisable as Aardman, he explained on the creative vision Greenpeace had. We wanted something that would be immediately accessible and would take people on a real emotional journey.

Till explained that emotional punch was a phrase that continued to surface throughout their discussions as Greenpeace knew that while it was good at delivering facts and figures, its not always enough to make the case or make people prioritize the issue.

Till said deciding on the director was a fun if agonising decision process where the team refined and narrowed the ideas until they settled on Gavin Strange.

Just hearing Gav talk about his vision showed he really got to the heart of the issue, Till explained. He not only understood it intellectually, but he had a really strong emotional connection to the story." An added extra, to heighten his pitch, Strange read it alongside an accompanying musical mood real.

With the initial premise agreed back in mid-September, Aardman got going on the animation, while Greenpeace stayed in close contact throughout this time, during which Till admits the main producer was his main speed dial.

We had to get it right as its a big story to tell in not so long a video, he explained. Further, because of the process of stop-motion animation, it needed to sign off the script, set and characters before filming started, as once its set in clay, so to speak, all the changes become more difficult. If you go back and reanimate it loses you days and lots of effort.

Due to the nature of stop motion, the team used an animated storyboard, instead of a script. This was so they could work out the timings of each shot down to a fraction of a second.

One issue arose around how the characters should be depicted, as they needed to agree on the exact species of turtle to focus on - down to the colour of the shell. And this needed to balance with the story itself, to ensure that each character was scientifically accurate, with clear distinctions and personalities.

The team then had to work to a tight schedule, to ensure it was ready by January to give it enough airtime to make waves before the final found of the United Nations ocean treaty in March.

To help manage the team. who were working individually on shots, Aardman put boards on the walls with pictures of each shot so they could move between studios to show how it was working out.

All in all, the stop motion recording took six weeks - a painstaking process given the total length of the film is just under two minutes.

The famous voices involved include Olivia Colman, Dame Helen Mirren, and David Harbour, alongside Game of Thrones Bella Ramsey, Downton Abbeys Jim Carter, and comedian Ahir Shah.

Other than the scientific data and facts, Greenpeace also has an extensive phonebook of famous stars keen to support its campaigns.

Colman really did put everything into it, Till said on the Oscar-winning actress' performance. She took time off from doing the final takes of The Crown to rush over and deliver the recordings in under an hour. She just got it."

Till said he was in Harbours ear during his recording, as the actor was working remotely in New York. He said the whole process was interesting to experience, as each famous voice approached the shoot in a different way.

"We don't want to be accused of being hyperbolic," claimed Till on why alongside the video, it has produced a report about the threats that are facing turtles in the real world. "We know it's crucial for us as a lobbying and scientific campaigning organisation we need to demonstrate that science is there to back this story up."

'Turtles Under Threat' reports that while the creature has traversed the world's oceans for more than 100 million years, now six in seven marine turtles are on the red list of the International Union for Conservation of Nature and are threatened with extinction.

"Unfortunately, our film might be fiction, but what happens to our turtle family in that film is sadly happening to real turtles all over the world," Till said dejectedly.

With the campaign launching last week, its still early days. But Greenpeace said it has already collected over 280,000 signatures - not far off its 300,000 target.

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Anatomy of an Ad: the story behind Greenpeace's harrowing tale of turtle extinction - The Drum