Anatomy

Anatomy of a grant: Ashley Kramer’s yearlong journey to finding her doctoral thesis – The South End

He asked her for a list of dream projects she would love to investigate. What followed was a year of challenges, stresses and the ultimate reward guided intellectual freedom toward scientific discovery.

Ashley Kramer, a student at the Wayne State University School of Medicine, is enrolled in the schools M.D.-Ph.D. program, an eight-year commitment broken down into three parts the first two years of medical school, four years of graduate school, then the final two years of medical school. Like all M.D./Ph.D. students at the medical school, Kramer had to complete research rotations with faculty she thought would make good dissertation advisors.

Because I have always loved stem cell biology and had experience working with zebrafish in the past, I decided to do an eight-week rotation in Dr. Thummels lab between my medical year one and medical year two, and made the decision that this was absolutely the perfect lab for me, she said.

Ryan Thummel, Ph.D., is an associate professor of Ophthalmology, Visual and Anatomical Sciences. His lab focuses on retinal development and regeneration in zebrafish, an attractive model to study neurodegenerative diseases because of its ability to regenerate neuronal tissues. Zebrafish fully regenerate their retinas in just a matter of weeks, an ability mammals lack.

Zebrafish and mammals both have a cell called Mller glia that supports retinal neurons. In zebrafish, however, these cells convert to stem cells and are responsible for retinal regeneration.

At the end of the rotation, Dr. Thummel floated the crazy idea of starting to work on this grant, a 70-plus page monster undertaking, during my M2 year, and I immediately jumped at the opportunity. I was excited at the idea of having a four-year research project completely planned out by the time I started my Ph.D. after M2 so I could hit the ground running after the dreaded STEP 1, Kramer said.

I came to him two days later with a nine-page document of project ideas. We sat down for three hours discussing projects and came up with a top-two list of cohesive projects for me to move forward with as a grant and thesis, she said. From there, it was a nearly yearlong process of writing, meeting, revising and repeating for each of the many sections of the grant.

The effort was worth it. Kramer secured a five-year, $294,102 grant from the National Eye Institute of the National Institutes of Health last year to study the molecular mechanisms of retinal regeneration in zebrafish, an organism that exhibits a remarkable capacity for regeneration.

"Ashley is a dedicated young scientist and worked very hard on this grant application," Dr. Thummel said.

The grant is one of the NIHs Ruth L. Kirschstein National Research Service awards, also known as an F30. The project, Elucidating the role of DNA methyltransferases in epigenetic regulation of retinal regeneration in the zebrafish, started last month. She is the principal investigator.

This was an incredibly challenging experience that allowed me to grow immensely as a scientist. Grant writing, planning effective and novel longitudinal scientific investigations, and time management will all be critical skills for me moving forward in my career as a physician scientist, she said. I cannot thank Dr. Thummel and my past advisors enough for all of their mentoring and support in the last ten years who have gotten me to where I am today, and I am looking forward to the rest of my training here at Wayne State and beyond.

Kramer earned her bachelors degree in Genetics, Cell Biology and Development from the University of Minnesota in 2014. Her love of research and stem cell biology started when she was an undergraduate research assistant there.

Nearly a decade later, she is studying how epigenetic marks are added to, and removed from, genes in zebrafish retinal stem cells during the process of retinal regeneration. The role of epigenetics in the body is akin to traffic signs on the road.

If roads had no traffic lights, stop signs or barricades, it would be complete chaos. The same is true for your cells. If you used every single gene encoded in your DNA 100% of the time, your cells would be chaos. Epigenetics is what is responsible for telling your skin cell to be a skin cell and your liver cell to be a liver cell, while they both have the exact same underlying DNA sequence, Kramer said. There are various different epigenetic marks that decorate the DNA without actually changing the sequence. These marks come in many forms and can act to either start, stop or change the amount that a particular gene is used, similar to how a green light, road block or stop sign direct traffic rules.

The process is critical for normal embryonic development and everyday cell processes.

If we can gain a deeper understanding of how species like the zebrafish are able to regenerate tissues when mammals cannot, despite having the same cell types, we may be able to start working to translate those mechanisms to mammals, she said. It is possible that certain regeneration pathways have been epigenetically silenced through evolution and we may be able to use modern advances in gene therapy techniques to unlock regenerative capacity in mammals.

Go here to see the original:
Anatomy of a grant: Ashley Kramer's yearlong journey to finding her doctoral thesis - The South End

Anatomy

TV Ratings: Greys Anatomy and Station 19 Reach Four-Week Viewership High – Variety

February 21, 2020 10:49AM PT

Greys Anatomy and its Station 19 both drew their largest total audiences in four weeks on Thursday night.

Station 19 ticked up from a 0.9 rating among adults 18-49 last week to a 1.0 this time around, drawing 6.3 million total viewers, a 4% bump. One hour later, Greys came in at a 1.1 and 6 million, a 7.5% jump from last week. A Million Little Things rounded off the night even for the Disney-owned network at a 0.6 and 3.7 million viewers.

Young Sheldon scored the largest audience on the night with 9 million total viewers and a 1.0 rating, almost exactly the same numbers as last episode. Both The Unicorn and Mom ticked down from their multi-week high 0.8 rating. The two shows came in at a 0.7 this time around, drawing 6 million and 6.2 million viewers respectively. Carols Second Act and Tommy held steady, scoring a 0.6 and a 0.4.

The majority of the shows in NBCs Thursday night comedy lineup improved week-to-week. Superstore rose to a 0.7 and 2.7 million viewers, Brooklyn Nine-Nine jumped to a 0.6 and 1.9 million, and Indebted ticked up to a 0.4 and 1.6 million. Will & Grace matched Indebted with a 0.4 and just over 2 million pairs of eyeballs. Law & Order: SVU came in even at a 0.7 and 3.4 million viewers.

There wasnt much movement on the Fox front Thursday night, as Outmatched and Deputy posted the same 0.5 rating as last week, with the former drawing 2 million viewers and the latter 3.3 million. Last Man Standing rose fractionally to a 0.7 and 3.6 million viewers.

Finally on the CW, Riverdale spinoff was even week-to-week at a 0.1 rating and around 540,000 total viewers.

More:
TV Ratings: Greys Anatomy and Station 19 Reach Four-Week Viewership High - Variety

Anatomy

Is Your Favorite Greys Anatomy Couple Really Over Forever? – Refinery29

Maggie is the one who spends Diagnosis trying to help her sister metabolize her pain over the Link situation. It would be easy for Greys to have Maggie, in this case the voice of reason, fully turn on Link because he made her sister sad. However, Maggie doesnt. During the meatiest part of the conversation when Maggie finally learns about the Owen part of the pregnancy equation Maggie explains why Links reaction to the messy paternity twist is sensible. She reminds Amelia that she and Owen have a complicated relationship, to put things mildly.

See the rest here:
Is Your Favorite Greys Anatomy Couple Really Over Forever? - Refinery29

Immunology

Neurology Professor from Harvard Medical School Wins Barancik Prize for Innovation in MS Research for Work Resulting in New Tools and Treatments to…

MEDIA CONTACT

Available for logged-in reporters only

Newswise Dr. Francisco J. Quintana, PhD, Professor of Neurology at Ann Romney Center for Neurologic Diseases at Brigham and Womens Hospital, Harvard Medical School, is the winner of the National Multiple Sclerosis Societys Barancik Prize for Innovation in MS Research.

While the genetic origins of MS are becoming better understood, its less known how environmental factorssuch as pollutants, diet and intestinal bacteriamight contribute to MS and its progression. It is also not yet known how risk factors influence the immune system to attack the central nervous system. To address these questions, Dr. Quintana uses cutting-edge technologies to study the regulation of immune responses and inflammation in MS, molecular changes that trigger MS and environmental factors that influence disease activity.

Through a series of high-impact publications, Dr. Quintanas work has contributed new tools to further the work of the MS research community. His research has led to potential drugs for treating progressive MS, and has contributed to the development of a designer treatment called nanoparticles to control autoimmune activity. He recently developed anti-inflammatory synthetic engineered probiotics as a novel approach to MS therapy, and his team is currently licensing these probiotics to a new biotech for their clinical testing.

I recently completed what is so far the largest single-cell analysis of central nervous system cells in MS and EAE models Since this work generated one of the largest datasets currently available, it provides a unique resource for the study of the CNS in health and disease, Dr. Quintana said. Thus, we expect these datasets and novel methods to have a deep impact on MS research.

As for future research plans, Dr. Quintana will serve as the lead researcher on an international collaboration to develop a pipeline to identify the origins of progressive MS and new or repurposed drugs to treat it. His long-term goal is to identify mechanisms of disease pathogenesis and develop therapies for progressive MS.

Dr. Quintana will receive the Barancik Prize and deliver the Prize lecture at the ACTRIMS Forum. ACTRIMS Forum brings together more than 1,200 researchers and clinicians annually to share developments in the rapidly changing field of MS. The 2020 Forum will be held Feb. 27-29, 2020, in West Palm Beach, Florida. Themed Networks in MS, this CME-accredited meeting stands apart from many traditional medical meetings by offering a single track of scientific and clinical presentations in an interactive environment.More information about ACTRIMS Forum appears on the events website. Follow the event at #ACTRIMS.

Dr. Quintana earned a diploma in biology from the University of Buenos Aires and a Ph.D. in immunology from the Weizmann Institute of Science in Rehovot, Israel. He completed his postdoctoral training with a focus on neuroimmunology at the Weizmann Institute and at BWH. Among his many awards are Young Investigator Awards in Ireland and Italy, a Pathway to Independence Award from NIAID/NIH, and the National Multiple Sclerosis Societys 2014 Harry Weaver Research Scholar Award and 2017 Milestones in MS Research Award. The recipient of the 2016 Young Mentor Award from Harvard Medical School, he has trained more than 30 graduate students and postdoctoral fellows, and participates in several programs focused on training scientists from underrepresented minorities. He directs the Autoimmunity post-graduate course at Harvard Medical School, and the Seminars in Immunology post-graduate course at the University of Sao Paulo, Brazil.

The Barancik Prize seeks to recognize and encourage exceptional innovation and originality in scientific research relevant to multiple sclerosis, with emphasis on impact and potential of the research to lead to pathways for the treatment and cure for MS, and scientific accomplishments that merit recognition as a future leader in MS research. The international prize is made possible by the generosity of the Charles and Margery Barancik Foundation, and is administered through the National Multiple Sclerosis Society.

Read about the Barancik Prize and previous recipients

About ACTRIMS Founded in 1995, Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) is a community of leaders from the United States and Canada who are dedicated to the treatment and research in MS and other demyelinating diseases. ACTRIMS focuses on knowledge dissemination, education and collaboration among disciplines. ACTRIMS also provides a Forum for experienced and newer clinicians and researchers to exchange information, debate current issues and discuss advances related to basic research and clinical issues.

View original post here:
Neurology Professor from Harvard Medical School Wins Barancik Prize for Innovation in MS Research for Work Resulting in New Tools and Treatments to...

Neuroscience

Jeremy Shaw explores neuroscience and science fiction in new installation – FACT

Phase Shifting Index is presented as part of the Mutations/Creations series at Center Pompidou.

Berlin-based artist Jeremy Shaw will debut a new solo work at Pariss Center Pompidou this month.

Phase Shifting Index arrives as part of the museums Mutations/Creations program, which previously has seen artists Ross Lovegrove, Ryoji Ikeda and Erika Verzutti showing work that exists at the border of art, science and engineering.

Drawing on Shaws enduring interest in ritual, dance, alternative culture, science-fiction and neuroscience, Phase Shifting Index is a new immersive installation that is a continuation on the themes of his recently completed Quantification Trilogy. Watch Jeremy Shaw talking about one of the films from that trilogy, Liminals, below.

Phase Shifting Index runs from February 26 to April 20 at Gallery 3, Centre Pompidou. Tickets are available now.

Watch next: CTM 2020 in videos Robert Henke, Teto Preto, Kamaal Williams and more

Go here to see the original:
Jeremy Shaw explores neuroscience and science fiction in new installation - FACT

Neuroscience

The Neuroscience Behind Kejriwals Victory – The Wire

Arvind Kejriwals victory is currently being viewed from the perspective of a development centred narrative coupled with a platitude of freebies offered by the Aam Admi Party (AAP). However, if one analyses past election results, voters have rejected pro-development governments on a number of occasions.

The governments of Narasimha Rao, as well as Vajpayee, were decisively rejected by the voters, despite their strong development-centric approaches. Freebies have been also rejected by voters rejection of Congress Nyay scheme during the 2019 elections is a glaring example. What then makes Kejriwal so special that both factors which have pushed many governments into oblivion worked in favour of AAP?

The answer to these questions lies in Neuroscience. We have all read about Pavlovs work on conditioned reflexes based on experiments, where an animal was given food and a bell was rung. After a while, the animal started feeling hungry and began to salivate when the bell was rung. This is also called classical conditioning where, a conditioned stimulus e.g. the sound of a bell, is paired with unconditioned stimulus e.g. food which evokes salivation which is an unconditioned response requiring no training.

After the pairing is repeated, the animal demonstrates a conditioned (or doctored) response to the conditioned stimulus or the external agent. The key observation is that repeated enforcement of a given pattern at the mental level, can actuate specific action patterns. This is exactly, what Kejriwal has done.

Also read: AAP: Soft Hindutva or a Bulwark Without Illusions?

He did not offer a one-time waiver of loans to people, as many other governments have done, as people are not only likely to forget it with time but their aspirations also rise, leading to an increase in anti-incumbency. Kejriwal partially waived off electricity and water bills, which impacted the public periodically while entrenching his image as a family caretaker.

Kejriwal identified two other areas, from which a conditioned response could be evoked within a definite timeframe education and health. He knew that improving the quality of education in government schools was extremely difficult to achieve in the short run, so he focused mainly on building classrooms in schools. Most people tend to cross a site near a school on a daily basis.

The emergence of huge buildings can convince people into believing that the quality of education is changing for the better. It affects parents, wards and the general public on a daily basis. Kejriwal also directed the remaining efforts towards the health sector. He set up Mohalla clinics, which may not offer quality health services, but the thought of someone in ones neighbourhood, to attend to them during distress can be a great mental stimulus for the voters.

Voters queue at a polling booth for the New Delhi assembly election in the Indian capital on February 8, 2020. Photo: Reuters

Kejriwal has always believed in making immediate and short term impact with minimal efforts. His odd-even scheme to control rising air pollution in the city was mostly hype and little substance, but people did talk about it while enhancing his pro-development image. His more recent efforts towards making bus transportation free for women also fall along this direction.

The voters of Delhi have failed to realise that Kejriwals investment in infrastructure-based projects, something which was radically done by the Sheila Dikshit government, has drastically fallen behind. For example, capital expenditure, which is associated with investments in infrastructure, has fallen to 0.54% of GSDP in 2018-19 from 1.16% in 2011-12. Declining tax revenues, which have dropped from 5.49% of GSDP in 2015-16 to 4.93% in 2018-19, are a cause of concern. But then, people tend to get swayed by actions having an immediate impact and this is one of the key pitfalls of democratic process.

Also read: AAP Has Successfully Forged a Model for Regional Forces to Emulate

The BJP government had sufficient time towards initiating a set of efforts directed towards creating a specific pro-development image and associated cognitive states in Delhi. For example, they could have set up dozens of central universities, hospitals and schools for residents, which could have had a cascading effect on peoples psyche.

Instead, the BJP chose to focus on things, which had absolutely very little cognitive value. Sentiment driven elements can also have strong cognitive values, but only when other narratives are absent. A typical middle-class family in Delhi cares little about Article 370, CAA and the Ram Temple. The BJPs rise in vote share is mostly driven by the disenchantment of a class which is fed up with schemes which benefit people and who do not pay direct taxes. It does not imply support for BJPs particular strategies, which would actually have minimal effect in their mental day to day lives.

In the context of Modis return to power, his schemes focusing on the construction of toilets, electricity connection and gas supplies in the rural sector also had a very strong cognitive value. The Balakot strikes galvanised his image as a strong leader, who could take decisive decisions. But in recent times, the impact of these narratives is slowly fading and people need newer and stronger initiatives which could excite favourable cognitive patterns. That has been one of the key reasons behind the BJPs dismal performance in key state elections.

There are significant barriers when it comes to replicating Kejriwals model at the national level. Offering free transport or waiving off electricity bills on a large scale is not economically feasible. Hence, AAP may find it difficult to leverage these successes on a pan India level, as his actions have localised cognitive values, confined to Delhi.

Also read: With Another Win in Delhi, Is Arvind Kejriwal Moving to the National Pulpit?

However, AAP does pose a significant threat as other governments may misread his adventurism in the field of freebies and can create a catastrophic burden on the taxpayer. Despite all these, he has sent a strong lesson to other governments that by focusing on health, education and basic necessities, voters thoughts can be significantly swayed in a specific direction, cutting across caste and religious lines, which carries some hope for the future.

Kejriwal has conditioned the psyche of Delhi in a manner that residents tend to strongly associate water, electricity, transportation, school and healthcare with him, which accounts for his grandiose victory in the heart of Hindi heartland.

Dhiraj Sinha holds a doctorate from the University of Cambridge. He has authored several research papers in the field of systems driven far away from equilibrium.

See the original post:
The Neuroscience Behind Kejriwals Victory - The Wire

Neuroscience

Out of the Basement: Early Results Promising for Portable MRI – MedPage Today

LOS ANGELES -- An investigational low-power MRI scanner appeared safe and feasible for use at the bedside in a standard neuroscience ICU, researchers reported.

The 64-mT portable machine under development by Hyperfine Research required no shielding, no special power supply, no changes to the equipment used in the patient's room, and no precautions for ferrous metal, Bradley Cahn, BS, of Yale University School of Medicine in New Haven, Connecticut, and colleagues reported here at the International Stroke Conference.

Among 96 stroke patients scanned non-acutely (minimum 9 hours post-onset, mean 87 hours), there were no "significant" adverse events. Overall, 87% of participants completed the full exam: six participants experienced claustrophobia, and five didn't fit head and shoulders comfortably into the 30-cm opening.

Acquisition times were about 7.5 minutes for T2-weighted scans, 9.5 for FLAIR, 9.8 for diffusion-weighted imaging, and just shy of 29 minutes for a full exam.

Portable CT machines are already in clinical use for stroke, notably in mobile stroke units, noted Ralph Sacco, MD, chairman of neurology at the University of Miami and past president of the American Heart Association.

"If we could get MRI as quickly as CT scanning, some of us would prefer MRI over CT," he said in an interview.

MRI is a more sensitive indicator of brain injury and can pick up ischemia much earlier in the process when CT might still give a false negative, he noted.

The bulky machines needed to generate high-powered 3- and even 7-T MRI, risk posed by stray metal, as well as the wait and acquisition times have been hurdles, though, Sacco added.

"We have this incredibly safe technology, MRI, and we've put it in depths of the hospital's basement where you have to travel with the patient to get to it," said Cahn. "We've flipped that and brought the magnet into the patient's room."

There are plenty of other possible useful applications, though, said Cahn. Availability in the emergency room and ambulance "would be huge."

However, 28 minutes -- while fast for MRI -- might be just too long to consider overthrowing CT as the standard for urgent diagnosis in most circumstances, said ISC session moderator Justin Fraser, MD, of the University of Kentucky in Lexington. But it could be particularly useful for posterior circulation strokes, to determine futility of thrombectomy, he suggested.

The device still needs to be tested in the acute setting, though, Cahn noted.

"I think what they intended to prove, they proved that it was both feasible and safe to do in this limited, single-center population," commented Peter Panagos, MD, of Washington University School of Medicine in St. Louis, and American Heart Association/American Stroke Association Stroke Council Chair.

The study included both intubated and non-intubated adults in the neuroscience ICU who needed imaging as standard of care. Those with contraindications to 1.5-T MRI were excluded.

In theory, the device should be compatible with MR-compatible pacemakers and similar devices, but that hasn't been tested yet either, noted Cahn. "We just don't know how the low field strength interacts with devices like that. For example, some devices [that] are safe at 3 T may not be at 7 T and vice versa."

Nor were any scans done with contrast administration. Those studies will come, Cahn said, and the device continues to be iteratively improved.

Disclosures

The trial was supported by Hyperfine Research, which is developing the device, and by the American Heart Association.

Cahn disclosed receiving grants from Hyperfine Research.

Coauthors included some employees of Hyperfine Research.

Panagos and Fraser disclosed no relevant relationships with industry.

Read the original:
Out of the Basement: Early Results Promising for Portable MRI - MedPage Today

Neuroscience

Scientists turn organs transparent and capture 3D pictures of what’s inside – STAT

Scientists in Germany have turned human organs transparent and captured pictures of the complex cellular architecture inside, the latest advance in an effort to develop a new way to see inside our tissues.

The new work involved a three-pronged approach: stripping the pigment and fats from organs; capturing images of entire organs with a specially designed, larger microscope; and developing an algorithms to analyze those images and spit out maps labeled with specific cellular structures.

But outside experts said the technique described in a paper published this month in Cell will need more polishing before it might be ready for prime time as a new imaging method.

advertisement

The paper delivers impressive proof-of-concept demonstrations [but] it still seems like early days for broader use of the tool, said Katrin Amunts, a neuroscientist and director of the Institute for Neuroscience and Medicine at Forschungszentrum Juelich in Germany, who wasnt involved in the research.

Currently, scientists can study organs in living individuals with the help of imaging tools such as MRI and CT scans. They can also study slices of tissue from organs obtained postmortem and, with the help of new technologies, piece pictures of those slices together into 3D images of an organs structures.

But Ali Ertrk, director of the Institute of Tissue Engineering and Regenerative Medicine at Ludwig Maximilians University of Munich and senior author of the new study, is hopeful that his new approach could one day offer a new way to study organs in even closer detail.

With our technology, we can see every single cell in an entire human organ, said Ertrk.

Ertrk and his colleagues started their work by hunting for chemicals that could clean out the pigments and fats in organs, which block light. Ertrks lab and other groups had been able to clear the color from mouse organs. But the chemicals that worked in mice didnt work for human tissue, which grows stiffer as collagen and other molecules accumulate over time.

They eventually pinpointed a detergent dubbed CHAPS, which created tiny holes throughout organs. The scientists could then soak the organs in other solutions that rendered them transparent without damaging the tissue structure.

Its like converting milk into water. It becomes transparent, Ertrk said.

Ertrk and his colleagues partnered with the German-based biotech company Miltenyi Biotec to design a fluorescent microscope big enough to fit an organ-sized tissue sample under the lens. The microscope works on a sample as big as a human kidney, but doesnt work on larger organs, such as the brain, which Ertrk and his colleagues have also been able to turn transparent.

The pictures the microscope captured create another challenge: how to process and analyze the massive amount of data generated by imaging human tissue at the cellular level.

Ertrk and his team collaborated with researchers at Technical University of Munich to develop algorithms that could analyze the structure of the organs, including the blood vessels and individual cells. The algorithm was roughly as accurate at labeling cell types as a human identifying the structures manually.

Its a task that would take 100 years by hand, and now takes hours, he said.

Taken together, the approach to clearing and imaging intact organs is called SHANEL. The technology is still in the early stages. Etrk and his colleagues are working to develop a larger microscope that can image larger organs. They are also continuing to sharpen the artificial intelligence arm of SHANEL, developing new algorithms for each internal structure they want to identify, whether thats a neuron or a glial cell in the brain.

Amunts, the Forschungszentrum Juelich neuroscientist, said scientists need to carefully study how the process of chemically clearing an organ might affect specific types of tissue, particularly in different regions of the brain. The brains regions vary more widely than tissues in other organs, like the kidney. Theres also a need for more research into the accuracy of clearing approaches and how they stack up to standard organ imaging methods, like looking at 3D images of brain slices.

It remains to be demonstrated that the tissue-clearing approach presented in the paper reaches the same precision, reliability, and reproducibility that established [methods] have, she said.

Ertrk is hopeful that SHANEL can be used in the future to generate 3D maps of human organs that offer new insight into their function, structure, and the role they play in disease. That could be a helpful tool in studying complex organs, such as the brain, experts said.

For basic science studies on the brains structure, I think this can become a very valuable complementary method in the toolset of neuroscientists, Amunts said.

In the long run, Ertrk wants to use those maps to 3D print organs that accurately replicate their natural counterparts, down to the cellular level. Doing so, in theory, could mean creating lab-grown organs that function and potentially, could one day be used for transplants, though theres far more research to be done before that becomes a possibility, Ertrk said.

See the article here:
Scientists turn organs transparent and capture 3D pictures of what's inside - STAT

Neuroscience

She overcame 6 brain surgeries and exchanged her hospital gown for scrubs: ‘It’s my destiny’ – wtvr.com

RICHMOND, Va. During her childhood, Alexa Nixon was more familiar with surgeons than swing sets and spent more time in the pediatric unit than the playground.

I was filled with hope, but I dont look hopeful, said Alexa.

When she was 11, she was wracked by seizures. An MRI revealed a brain tumor the size of a ping pong ball. She had her first surgery in 2005. It would be the first of six brain surgeries.

Waking up out of surgery I couldnt move my left side at all, Alexa recalled. It was also told to me that the likelihood of me walking was small if not none. Then in 2012, I got to the point where I was having on average 10 to 12 seizures a day.

During her long recovery, caregivers left a deep impression on Alexa.

I was very intrigued, and I asked a lot of questions to the nurses that took care of me because I realized this is something, I might want to do one day, she said.

So, Alexa set a goal.

When we first met Alexa in 2016, she was working toward her degree in nursing. You would understand if Alexa wanted nothing to do with hospitals. Today, it's where the 26-year-old feels most comfortable.

I know where I am is where Im supposed to be, said Alexa.

Alexa works in the Acute Neuroscience Unit at VCU Medical Center as a nurse. It is the same unit where she spent so much time as a child.

Its my destiny. And every day I get to live out my destiny, said Alexa.

Alexa sees herself in the faces of the patients she cares for.

Sometimes it hits too close to home, but it makes me that much more driven, said Alexa.

She credits her faith, family and friends with helping her recover and reach her goal.

Every morning when I come to work, I know Im coming to work to do Gods work, she said.

Fellow nurses Jillian Phillips and Morgan Knowles say their colleague possesses intangibles you just can't learn in a classroom.

Oh, Definitely. Yeah. She was definitely made to be a nurse and be there for other people, said Morgan.

She is what you would imagine as the most trusted profession. What people look to as a nurse that is Alexa, added Jillian.

Alexa is setting out on her calling rather than a career.

If in some freak way that Nursing was not a paid profession it would be my hobby, said Alexa.

Alexa Nixon, a one-time patient realizing her dream of helping others all while exchanging her hospital gown for scrubs.

I obviously want to grow as a nurse and in leadership, but I never want to leave the bedside because the patient relationship is why Im here, said Alexa.

Greg McQuade features local heroes in a weekly Heroes Among Us segment. If you would like to nominate someone to be featured on Heroes Among Us, click here to email heroes@wtvr.com.

Read this article:
She overcame 6 brain surgeries and exchanged her hospital gown for scrubs: 'It's my destiny' - wtvr.com

Neuroscience

Neuroscience Antibodies and Assays Market Latest Trends, Business Strategies, Regional Demand, Key Insights and Future Outlook by 2023 – Jewish Life…

In the context of China-US trade war and global economic volatility and uncertainty, it will have a big influence on this market. Neuroscience Antibodies and Assays Report by Material, Application, and Geography Global Forecast to 2023 is a professional and comprehensive research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom, Japan, South Korea and China).

In this report, the global Neuroscience Antibodies and Assays market is valued at USD XX million in 2020 and is projected to reach USD XX million by the end of 2024, growing at a CAGR of XX% during the period 2020 to 2024.

The report firstly introduced the Neuroscience Antibodies and Assays basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.

The major players profiled in this report include:AbcamBio-Rad LaboratoriesCell Signaling TechnologyRocheMerck KGaATecan GroupThermo Fisher Scientific

The end users/applications and product categories analysis:On the basis of product, this report displays the sales volume, revenue (Million USD), product price, market share and growth rate of each type, primarily split into-General Type

On the basis on the end users/applications, this report focuses on the status and outlook for major applications/end users, sales volume, market share and growth rate of Neuroscience Antibodies and Assays for each application, including-Medical

Table of Contents

Part I Neuroscience Antibodies and Assays Industry Overview

Chapter One Neuroscience Antibodies and Assays Industry Overview1.1 Neuroscience Antibodies and Assays Definition1.2 Neuroscience Antibodies and Assays Classification Analysis1.2.1 Neuroscience Antibodies and Assays Main Classification Analysis1.2.2 Neuroscience Antibodies and Assays Main Classification Share Analysis1.3 Neuroscience Antibodies and Assays Application Analysis1.3.1 Neuroscience Antibodies and Assays Main Application Analysis1.3.2 Neuroscience Antibodies and Assays Main Application Share Analysis1.4 Neuroscience Antibodies and Assays Industry Chain Structure Analysis1.5 Neuroscience Antibodies and Assays Industry Development Overview1.5.1 Neuroscience Antibodies and Assays Product History Development Overview1.5.1 Neuroscience Antibodies and Assays Product Market Development Overview1.6 Neuroscience Antibodies and Assays Global Market Comparison Analysis1.6.1 Neuroscience Antibodies and Assays Global Import Market Analysis1.6.2 Neuroscience Antibodies and Assays Global Export Market Analysis1.6.3 Neuroscience Antibodies and Assays Global Main Region Market Analysis1.6.4 Neuroscience Antibodies and Assays Global Market Comparison Analysis1.6.5 Neuroscience Antibodies and Assays Global Market Development Trend Analysis

Chapter Two Neuroscience Antibodies and Assays Up and Down Stream Industry Analysis2.1 Upstream Raw Materials Analysis2.1.1 Proportion of Manufacturing Cost2.1.2 Manufacturing Cost Structure of Neuroscience Antibodies and Assays Analysis2.2 Down Stream Market Analysis2.2.1 Down Stream Market Analysis2.2.2 Down Stream Demand Analysis2.2.3 Down Stream Market Trend Analysis

Part II Asia Neuroscience Antibodies and Assays Industry (The Report Company Including the Below Listed But Not All)

Chapter Three Asia Neuroscience Antibodies and Assays Market Analysis3.1 Asia Neuroscience Antibodies and Assays Product Development History3.2 Asia Neuroscience Antibodies and Assays Competitive Landscape Analysis3.3 Asia Neuroscience Antibodies and Assays Market Development Trend

Chapter Four 2015-2020 Asia Neuroscience Antibodies and Assays Productions Supply Sales Demand Market Status and Forecast4.1 2015-2020 Neuroscience Antibodies and Assays Production Overview4.2 2015-2020 Neuroscience Antibodies and Assays Production Market Share Analysis4.3 2015-2020 Neuroscience Antibodies and Assays Demand Overview4.4 2015-2020 Neuroscience Antibodies and Assays Supply Demand and Shortage4.5 2015-2020 Neuroscience Antibodies and Assays Import Export Consumption4.6 2015-2020 Neuroscience Antibodies and Assays Cost Price Production Value Gross Margin

Chapter Five Asia Neuroscience Antibodies and Assays Key Manufacturers Analysis5.1 Company A5.1.1 Company Profile5.1.2 Product Picture and Specification5.1.3 Product Application Analysis5.1.4 Capacity Production Price Cost Production Value5.1.5 Contact Information5.2 Company B5.2.1 Company Profile5.2.2 Product Picture and Specification5.2.3 Product Application Analysis5.2.4 Capacity Production Price Cost Production Value5.2.5 Contact Information5.3 Company C5.3.1 Company Profile5.3.2 Product Picture and Specification5.3.3 Product Application Analysis5.3.4 Capacity Production Price Cost Production Value5.3.5 Contact Information5.4 Company D5.4.1 Company Profile5.4.2 Product Picture and Specification5.4.3 Product Application Analysis5.4.4 Capacity Production Price Cost Production Value5.4.5 Contact InformationChapter Six Asia Neuroscience Antibodies and Assays Industry Development Trend6.1 2020-2024 Neuroscience Antibodies and Assays Production Overview6.2 2020-2024 Neuroscience Antibodies and Assays Production Market Share Analysis6.3 2020-2024 Neuroscience Antibodies and Assays Demand Overview6.4 2020-2024 Neuroscience Antibodies and Assays Supply Demand and Shortage6.5 2020-2024 Neuroscience Antibodies and Assays Import Export Consumption6.6 2020-2024 Neuroscience Antibodies and Assays Cost Price Production Value Gross Margin

Part III North American Neuroscience Antibodies and Assays Industry (The Report Company Including the Below Listed But Not All)

Chapter Seven North American Neuroscience Antibodies and Assays Market Analysis7.1 North American Neuroscience Antibodies and Assays Product Development History7.2 North American Neuroscience Antibodies and Assays Competitive Landscape Analysis7.3 North American Neuroscience Antibodies and Assays Market Development Trend

Chapter Eight 2015-2020 North American Neuroscience Antibodies and Assays Productions Supply Sales Demand Market Status and Forecast8.1 2015-2020 Neuroscience Antibodies and Assays Production Overview8.2 2015-2020 Neuroscience Antibodies and Assays Production Market Share Analysis8.3 2015-2020 Neuroscience Antibodies and Assays Demand Overview8.4 2015-2020 Neuroscience Antibodies and Assays Supply Demand and Shortage8.5 2015-2020 Neuroscience Antibodies and Assays Import Export Consumption8.6 2015-2020 Neuroscience Antibodies and Assays Cost Price Production Value Gross Margin

Chapter Nine North American Neuroscience Antibodies and Assays Key Manufacturers Analysis9.1 Company A9.1.1 Company Profile9.1.2 Product Picture and Specification9.1.3 Product Application Analysis9.1.4 Capacity Production Price Cost Production Value9.1.5 Contact Information9.2 Company B9.2.1 Company Profile9.2.2 Product Picture and Specification9.2.3 Product Application Analysis9.2.4 Capacity Production Price Cost Production Value9.2.5 Contact InformationChapter Ten North American Neuroscience Antibodies and Assays Industry Development Trend10.1 2020-2024 Neuroscience Antibodies and Assays Production Overview10.2 2020-2024 Neuroscience Antibodies and Assays Production Market Share Analysis10.3 2020-2024 Neuroscience Antibodies and Assays Demand Overview10.4 2020-2024 Neuroscience Antibodies and Assays Supply Demand and Shortage10.5 2020-2024 Neuroscience Antibodies and Assays Import Export Consumption10.6 2020-2024 Neuroscience Antibodies and Assays Cost Price Production Value Gross Margin

Part IV Europe Neuroscience Antibodies and Assays Industry Analysis (The Report Company Including the Below Listed But Not All)

Chapter Eleven Europe Neuroscience Antibodies and Assays Market Analysis11.1 Europe Neuroscience Antibodies and Assays Product Development History11.2 Europe Neuroscience Antibodies and Assays Competitive Landscape Analysis11.3 Europe Neuroscience Antibodies and Assays Market Development Trend

Chapter Twelve 2015-2020 Europe Neuroscience Antibodies and Assays Productions Supply Sales Demand Market Status and Forecast12.1 2015-2020 Neuroscience Antibodies and Assays Production Overview12.2 2015-2020 Neuroscience Antibodies and Assays Production Market Share Analysis12.3 2015-2020 Neuroscience Antibodies and Assays Demand Overview12.4 2015-2020 Neuroscience Antibodies and Assays Supply Demand and Shortage12.5 2015-2020 Neuroscience Antibodies and Assays Import Export Consumption12.6 2015-2020 Neuroscience Antibodies and Assays Cost Price Production Value Gross Margin

Chapter Thirteen Europe Neuroscience Antibodies and Assays Key Manufacturers Analysis13.1 Company A13.1.1 Company Profile13.1.2 Product Picture and Specification13.1.3 Product Application Analysis13.1.4 Capacity Production Price Cost Production Value13.1.5 Contact Information13.2 Company B13.2.1 Company Profile13.2.2 Product Picture and Specification13.2.3 Product Application Analysis13.2.4 Capacity Production Price Cost Production Value13.2.5 Contact InformationChapter Fourteen Europe Neuroscience Antibodies and Assays Industry Development Trend14.1 2020-2024 Neuroscience Antibodies and Assays Production Overview14.2 2020-2024 Neuroscience Antibodies and Assays Production Market Share Analysis14.3 2020-2024 Neuroscience Antibodies and Assays Demand Overview14.4 2020-2024 Neuroscience Antibodies and Assays Supply Demand and Shortage14.5 2020-2024 Neuroscience Antibodies and Assays Import Export Consumption14.6 2020-2024 Neuroscience Antibodies and Assays Cost Price Production Value Gross Margin

Part V Neuroscience Antibodies and Assays Marketing Channels and Investment Feasibility

Chapter Fifteen Neuroscience Antibodies and Assays Marketing Channels Development Proposals Analysis15.1 Neuroscience Antibodies and Assays Marketing Channels Status15.2 Neuroscience Antibodies and Assays Marketing Channels Characteristic15.3 Neuroscience Antibodies and Assays Marketing Channels Development Trend15.2 New Firms Enter Market Strategy15.3 New Project Investment Proposals

Chapter Sixteen Development Environmental Analysis16.1 China Macroeconomic Environment Analysis16.2 European Economic Environmental Analysis16.3 United States Economic Environmental Analysis16.4 Japan Economic Environmental Analysis16.5 Global Economic Environmental Analysis

Chapter Seventeen Neuroscience Antibodies and Assays New Project Investment Feasibility Analysis17.1 Neuroscience Antibodies and Assays Market Analysis17.2 Neuroscience Antibodies and Assays Project SWOT Analysis17.3 Neuroscience Antibodies and Assays New Project Investment Feasibility Analysis

Part VI Global Neuroscience Antibodies and Assays Industry Conclusions

Chapter Eighteen 2015-2020 Global Neuroscience Antibodies and Assays Productions Supply Sales Demand Market Status and Forecast18.1 2015-2020 Neuroscience Antibodies and Assays Production Overview18.2 2015-2020 Neuroscience Antibodies and Assays Production Market Share Analysis18.3 2015-2020 Neuroscience Antibodies and Assays Demand Overview18.4 2015-2020 Neuroscience Antibodies and Assays Supply Demand and Shortage18.5 2015-2020 Neuroscience Antibodies and Assays Import Export Consumption18.6 2015-2020 Neuroscience Antibodies and Assays Cost Price Production Value Gross Margin

Chapter Nineteen Global Neuroscience Antibodies and Assays Industry Development Trend19.1 2020-2024 Neuroscience Antibodies and Assays Production Overview19.2 2020-2024 Neuroscience Antibodies and Assays Production Market Share Analysis19.3 2020-2024 Neuroscience Antibodies and Assays Demand Overview19.4 2020-2024 Neuroscience Antibodies and Assays Supply Demand and Shortage19.5 2020-2024 Neuroscience Antibodies and Assays Import Export Consumption19.6 2020-2024 Neuroscience Antibodies and Assays Cost Price Production Value Gross Margin

Chapter Twenty Global Neuroscience Antibodies and Assays Industry Research Conclusions

Orbis Research (orbisresearch.com) is a single point aid for all your market research requirements. We have vast database of reports from the leading publishers and authors across the globe. We specialize in delivering customized reports as per the requirements of our clients. We have complete information about our publishers and hence are sure about the accuracy of the industries and verticals of their specialization. This helps our clients to map their needs and we produce the perfect required market research study for our clients.

Hector CostelloSenior Manager Client Engagements4144N Central Expressway,Suite 600, Dallas,Texas 75204, U.S.A.Phone No.: +1 (972)-362-8199; +91 895 659 5155

Go here to see the original:
Neuroscience Antibodies and Assays Market Latest Trends, Business Strategies, Regional Demand, Key Insights and Future Outlook by 2023 - Jewish Life...