Miss America speaks on the importance of STEM during visit to Norfolk elementary school – 13newsnow.com WVEC

Camille Schrier, a biochemistry major at Virginia Tech, told young girls at Oceanair Elementary they shouldn't be afraid to embrace STEM education.

NORFOLK, Va. Students at a Norfolk elementary school got a special surprise when Miss America came by for a visit!

Camille Schrier stopped by Oceanair Elementary on Thursday. She's a biochemistry major at Virginia Tech and spoke to little girls about all kinds of STEM topics, telling them they shouldn't be afraid to embrace STEM education.

"The message that I hope to impart is authenticity," Schrier said. "Whether that girl in the audience loves science or loves something else, to know that you can do something completely different and take a risk and know that doing what is important to you is the basis of success."

You may remember, Schrier's science skills were what helped her earn the Miss America title when she did an experiment for the talent portion of the competition.

"We lack a lot of female role models in science for those young girls, and I didn't really have that when I was their age," she said. "So I think it's a really great opportunity for me to inspire them and show them that science is cool and fun and you can be a girl with a crown on and also do science, and that's really the message I hope to impart on them."

Schrier will spend a lot of the next year touring different schools, encouraging girls to get into science. She is the fourth Miss Virginia to win the Miss America title.

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Miss America speaks on the importance of STEM during visit to Norfolk elementary school - 13newsnow.com WVEC

New bile discovery will rewrite textbooks – MSUToday

Forget what you know about bile because thats about to change, thanks to a new discovery made by Michigan State University and published in the current issue of Nature.

Much of our knowledge about bile hasnt changed in many decades. Its produced in the liver, stored in our gall bladder and injected into our intestine when we eat, where it breaks down fats in our gut. In fact, the first bile acid was discovered in 1848, and the scientists who revealed the structure of bile acids in 1928 won the Nobel Prize. Thats a long time ago.

Since then, our understanding of the chemistry of bile production in the liver was that the cholesterol backbone of the bile acid structure is linked to the amino acids glycine or taurine to produce our primary bile acids, said Robert Quinn, assistant professor of biochemistry and molecular biology and Global Impact researcher, and lead author of the study. It begs the question of how the new bile acids weve discovered have remained hidden during the last 170 years of bile acid chemical research.

These new bile acids are not produced by our enzymes; theyre made by microbes in our gut. This discovery will change how medical textbooks address digestion, and it contributes to an ever-growing body of knowledge supporting the importance of the microbiome, the collective community of bacteria and other microorganisms living in our guts.

Quinns team, comprised of scientists from MSU, the University of California San Diego and a number of collaborating institutions, showed that microbes in the gut, members of the microbiome, produce unique bile acids by conjugating the cholesterol backbone with myriad other amino acids.

This represents a fifth mechanism of bile acid metabolism by the microbiome that greatly expands our understanding of mammalian bile.

While much of the study was conducted in mice, these novel bile acids were also found in humans. And heres the kicker that will guide future research: Theyre particularly abundant in the guts of people suffering with gastrointestinal diseases, such as Crohns disease and cystic fibrosis.

These molecules can alter signaling pathways in the human gut that result in a reduction of overall bile acid production, representing a new mechanism where our gut bacteria can manipulate our own physiology, Quinn said.

While the disease connection is an intriguing line of research, this is merely one aspect being pursued by Quinns lab.

Clearly, our understanding of these compounds is in its infancy, Quinn said. This exciting new discovery opens more questions than answers about these compounds and their role in our health.

(Note for media: Please include a link to the original paper in online coverage: https://www.nature.com/articles/s41586-020-2047-9)

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New bile discovery will rewrite textbooks - MSUToday

Veterinary Biochemistry Analyzers Market: Incredible Possibilities, Growth With Industry Study, Detailed Analysis And Forecast To 2078 – Jewish Life…

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Veterinary Biochemistry Analyzers Market: Incredible Possibilities, Growth With Industry Study, Detailed Analysis And Forecast To 2078 - Jewish Life...

CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2. – Physician’s Weekly

The aim of this study was to investigate the possible influences of circPRKCI abnormal expression on lipopolysaccharide (LPS)-induced HK2 cell injury and its mechanism. The circPRKCI level was identified in serum samples from patients with urosepsis and healthy subjects, as well as LPS-treated HK2 cells by qRT-PCR. Cell viability, apoptosis, expression of proteins associated with apoptosis, and expression of pro-inflammatory cytokines in LPS-treated HK2 cells were measured. Effects of circPRKCI abnormal expression on LPS-induced HK2 cell injury were then evaluated. Afterward, the binding miRNA of circPRKCI and target gene of miRNA were identified, and the involvements of NF-kB pathway signaling pathway with the effects of circPRKCI were finally studied. CircPRKCI was significantly down-regulated in serum samples from patients with urosepsis and LPS-treated HK2 cells. LPS-induced decrease of cell viability, increase of cell apoptosis, as well as elevated productions of tumor necrosis factor (TNF)-, interleukins (IL)-1, IL-6, and IL-8 in HK2 cells were attenuated by overexpressed circPRKCI. In addition, circPRKCI negatively regulated the expression of miR-545, and miR-545 up-regulation reversed the inhibiting effects of circPRKCI overexpression on LPS-induced HK2 cell injury. Moreover, zinc finger E-box-binding homeobox 2 (ZEB2) was identified as a target gene of miR-545, and ZEB2 overexpression partly reversed the effects of miR-545 up-regulation on LPS-induced HK2 cell injury. Furthermore, NF-kB pathway was revealed to be associated to the effects of circPRKCI on LPS-induced HK2 cell injury. This research indicated that the highly expressed circPRKCI relieved inflammatory injury induced by LPS in HK2 cells by suppressing miR-545/ZEBs and depressing the briskness of NF-kB pathway. 2020 International Union of Biochemistry and Molecular Biology.

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CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2. - Physician's Weekly

New Jekyll and Hyde Immune Cell Discovered – Technology Networks

Scientists from Trinity have identified a rare, new cell in the immune system with Jekyll and Hyde properties. These cells play a key protective role in immunity to infection but if unregulated also mediate tissue damage in autoimmune disorders.The findings should help us design more effective vaccines to prevent infections such as MRSA, and may also assist help us develop of new therapies for autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis.

The research was funded by Science Foundation Ireland and led by Kingston Mills, Professor of Experimental Immunology, and Dr Sarah Edwards and Dr Caroline Sutton, Postdoctoral Fellows in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute.

The immune system functions to control infection, utilizing various immune cells, such as T cells to respond to and control invading microbes. However, if these immune cells are not highly regulated, they can attack and damage body tissues, leading to the development of autoimmune diseases.

Molecules called T cell receptors (TCRs) allow T cells to recognize components of infectious agents with exquisite specificity. The TCRs enable T cells to respond to and eventually eliminate the infectious agent.

Professor Mills said:

"Until now scientists thought that there were two discrete populations of T cells, expressing either '' or '' TCRs. The s are the most common T cells in the body. They play a key role in remembering prior infection or immunization and thereby help protect us against re-infection and mediate vaccine-induced protective immunity. The s are more prevalent at mucosal surfaces, such as the lung or gut, and provide an immediate first line of defense against pathogens that invade through these routes."

"We have discovered a new cell type that expresses both and TCRs. This rare population of chimeric or hybrid - T cells has properties of both and T cells. Importantly, they are normally highly activated and poised to act as first responders to control bacterial infection. However, given this high level of activation, they are effectively 'Jekyll and Hyde cells' because in certain contexts they can also precipitate autoimmune responses."

Using a model of Staphylococcus aureus infection, Professor Mills and his team found that these cells are rapidly mobilized during infection and play a key role in quickly eliminating the microbes from the body.

The induction of these hybrid - T cells may thus represent a novel approach in the design of more effective vaccines against Staph aureus and other infectious diseases, while advancing our ability to control their response may yield additional therapeutic options.

Professor Mills added:

In a model of autoimmune disease, we found that the hybrid T cells can also trigger the inflammatory cascade that mediates tissue damage in autoimmunity. Therefore, approaches for inhibiting these highly activated immune cells in susceptible individuals may open up new approaches for the treatment of autoimmune diseases such as psoriasis and multiple sclerosis.ReferenceEdwards et al. (2020) A population of proinflammatory T cells coexpresses and T cell receptors in mice and humans. Journal of Experimental Medicine. DOI: https://doi.org/10.1084/jem.20190834

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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New Jekyll and Hyde Immune Cell Discovered - Technology Networks

Biochemistry Analyzers Market Analysis and Forecast to 2026 by Recent Trends, Developments in Manufacturing Technology and Regional Growth Overview -…

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Biochemistry Analyzers Market Analysis and Forecast to 2026 by Recent Trends, Developments in Manufacturing Technology and Regional Growth Overview -...

Allergists offer advice to parents of kids with food allergies – Reuters

(Reuters Health) - Parents of children with food allergies should acknowledge their kids anxiety, as well as their own, a group of allergy experts advises.

Food allergies affect children of different ages in different ways and can influence relationships with classmates, family and the general public, according to the study in the Annals of Allergy, Asthma & Immunology.

Quality of life issues related to food allergies are ubiquitous, said co-author Dr. Ruchi Gupta, director of the Center for Food Allergy and Asthma Research at the Northwestern Feinberg School of Medicine in Chicago.

Coping with food allergies impacts relationship skills with peers and classmates, emerging independence and sense of self-efficacy, social skills and confidence, willingness to participate in sports teams, dating and more, she told Reuters Health by email. Coping is an individual internal experience, too: Feelings of worry and anxiety can color all thinking and generate anxiety about many life experiences.

About 8% of children in the U.S. have been diagnosed with a food allergy, according to the American Academy of Pediatrics. Allergic reactions to foods tend to be among the most severe, and potentially life-threatening, the study authors note.

Anaphylaxis, the most severe allergic reaction, can be reversed with a shot of epinephrine from an auto-injector like the EpiPen.

To examine the challenges children with life-threatening food allergies and their families encounter, which ones cause the most anxiety and what positive coping patterns work best, Gupta and colleagues interviewed six board-certified allergists who treat a large number of children with food allergies.

Overall, the allergists said, diagnosis, management and treatment occur along a spectrum, and its not a one size fits all practice. Younger children, for instance, may not be especially anxious about food, but their parents often are. Although older children may have better understanding and control of their food allergy, they participate in more independent activities, which can create heightened parental anxiety.

Kids with food allergies experience anxiety as a result of their parents stress, as well as fear of the auto-injector needle, anaphylaxis, food allergy tests and oral immunotherapy. The fallout that follows an allergic reaction can also be complex and interfere with everyday functioning. Successfully using epinephrine, however, can build confidence and bring a sense of relief after facing the unknown.

The allergists also talked about creating thoughtful and balanced communication, having credible health information to share with children, and supporting a positive feedback loop between parents and children rather than one that builds anxiety. Parents should be encouraged to transfer their knowledge to children, not all of their worries, one expert remarked.

Psychosocial coping with food allergies can be understood and managed when clear communication is present between parents and children and between healthcare providers and patients, Gupta said. It is a balance between lots of sound medical information and a good understanding of a childs risks and coping resources.

Coping is often impeded by misinformation about food allergies, the experts said, so its important for parents to receive consistent messaging and counseling for the family, if necessary.

You are taking care of the kids, but you are (also) managing the family unit, as you should be, one allergist said.

Brochures, apps, virtual groups and other educational materials can offer scientifically informed resources for parents and kids to manage food allergies. Gupta and colleagues are now collecting information in an online survey about the coping strategies and integrative medicine that parents and children have used.

Its important for families to know that its normal to be stressed about food allergy and feel overwhelmed, worried, sad or frustrated at times, said Linda Herbert, director of the Psychosocial Services Program for the Division of Allergy and Immunology at Childrens National Hospital in Washington, D.C.

But its equally important to know that they can get help from a professional, Herbert, who wasnt involved in the study, told Reuters Health by email. The mental health and allergy communities are paying more and more attention to the needs of food allergy families, and we are working hard to increase the number of mental health professionals who are equipped to do so.

SOURCE: bit.ly/2utQCOm Annals of Allergy, Asthma & Immunology, online February 25, 2020.

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Allergists offer advice to parents of kids with food allergies - Reuters

Roche To Top $66 Billion In Sales By 2020, Led By Neuroscience – Nasdaq

Roche Holdings(OTCMKTS:RHHBY) revenue grew at a CAGR of 5.3% from $52.5 billion in 2015 to $64.4 billion in 2019, and it is estimated to top $66 billion in 2020, led by its Neuroscience drugs. The companys oncology drugs will account for 45% of the companys total sales in 2020, but Neuroscience drugs are key to the near term revenue growth, in our view.Oncology drugs are expected to be the single-biggest revenue driver with $30.1 billion in revenues (45% of Total Revenues), which is 5.7x the size of its Neuroscience drugs revenue in 2020. Neuroscience drugs revenues, which includes Ocrevus and Modopar among other drugs, will be the fastest-growing segment adding $3.7 billion over 2017-2020 (32% of $11.6 billion in incremental revenues). Oncology drugs revenues, which includes Herceptin, Perjeta, Tecentriq, and Avastin among other drugs, will add about $3.4 billion over 2017-2020 (29% of the $11.6 billion in incremental revenue). Look at our interactive dashboard analysis on Roches Revenues for more details, parts of which are highlighted below.

Roches Revenue Has Been On A Rise Over The Last Few Years

Comparing Roches Sales Growth To Its Peers

Roche Has One of The Largest Oncology Drugs Portfolio, But It Is Expected To See A Decline Going Forward.

Ocrevus Has Been The Best Drug Launch Ever For Roche, Boosting Its Neuroscience Drugs Portfolio

Other Therapeutic Drugs Could Also See Growth In The Near Term

Among Other Segments, In-Vitro Diagnostics Could Continue To Grow At A Steady Pace, While Immunology, Ophthalmology, And Virology Drugs Could See A Decline

See allTrefis Price EstimatesandDownloadTrefis Datahere

Whats behind Trefis? See How Its Powering New Collaboration and What-Ifs ForCFOs and Finance Teams|Product, R&D, and Marketing Teams

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

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Roche To Top $66 Billion In Sales By 2020, Led By Neuroscience - Nasdaq

New immune cell with ‘Jekyll and Hyde properties’ identified – The Medical News

Scientists at Trinity College Dublin have identified a rare, new cell in the immune system with "Jekyll and Hyde properties". These cells play a key protective role in immunity to infection but - if unregulated - also mediate tissue damage in autoimmune disorders.

The findings should help us design more effective vaccines to prevent infections such as MRSA, and may also assist help us develop of new therapies for autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis.

The research was funded by Science Foundation Ireland and led by Kingston Mills, Professor of Experimental Immunology, and Dr. Sarah Edwards and Dr. Caroline Sutton, Postdoctoral Fellows in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute. Their findings were published today [Thursday 27th February 2020] in The Journal of Experimental Medicine.

The immune system functions to control infection, utilizing various immune cells, such as T cells to respond to and control invading microbes. However, if these immune cells are not highly regulated, they can attack and damage body tissues, leading to the development of autoimmune diseases.

Molecules called T cell receptors (TCRs) allow T cells to recognize components of infectious agents with exquisite specificity. The TCRs enable T cells to respond to and eventually eliminate the infectious agent.

Professor Kingston Mills said:

Until now scientists thought that there were two discrete populations of T cells, expressing either '' or '' TCRs. The s are the most common T cells in the body. They play a key role in remembering prior infection or immunization and thereby help protect us against re-infection and mediate vaccine-induced protective immunity. The s are more prevalent at mucosal surfaces, such as the lung or gut, and provide an immediate first line of defense against pathogens that invade through these routes."

We have discovered a new cell type that expresses both and TCRs. This rare population of chimeric or hybrid - T cells has properties of both and T cells. Importantly, they are normally highly activated and poised to act as first responders to control bacterial infection. However, given this high level of activation, they are effectively 'Jekyll and Hyde cells' because in certain contexts they can also precipitate autoimmune responses."

Using a model of Staphylococcus aureus infection, Professor Mills and his team found that these cells are rapidly mobilized during infection and play a key role in quickly eliminating the microbes from the body.

The induction of these hybrid - T cells may thus represent a novel approach in the design of more effective vaccines against Staph aureus and other infectious diseases, while advancing our ability to control their response may yield additional therapeutic options.

Professor Mills added:

In a model of autoimmune disease, we found that the hybrid T cells can also trigger the inflammatory cascade that mediates tissue damage in autoimmunity. Therefore, approaches for inhibiting these highly activated immune cells in susceptible individuals may open up new approaches for the treatment of autoimmune diseases such as psoriasis and multiple sclerosis."

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New immune cell with 'Jekyll and Hyde properties' identified - The Medical News

Does the Drug Used in Anesthesia Contain Egg and Soy? – Allergic Living

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Published:February 28, 2020

Q: Our teenage daughter with egg and soy allergies has to have surgery. Ive been told that the drug propofol used in anesthesia contains both egg and soy. Is that correct and should I be concerned?

Dr. Sharma: Propofol is mixed in a liquid which contains soybean oil and egg lecithin (a fatty substrate).

For people like your daughter, who have soy or egg allergies, they are allergic to the proteins in these foods, not the oils or fats.

While in theory soy oil and egg lecithin might contain trace amounts of protein, there are no reports in the medical literature of any allergic reactions caused by these ingredients.

There have been reports of allergic reactions to propofol in medical literature. But none of these appear to be related to soy or egg allergy.

Therefore, the general recommendation is that patients who require anesthesia with soy or egg allergy can receive propofol. But be sure to check with your daughters allergist to discuss her particular case.

Dr. Sharma is an allergist, clinical researcher andassociateprofessor of pediatrics. He isChiefof the Division of Allergy and Immunology at Childrens National Medical Center in Washington D.C. and Director of the Food Allergy Program. He co-authors The Food Allergy Experts column inAllergic Livings e-magazine. Questions submitted will be considered for answer in the e-magazine.

Related:The Truth About Drug AllergiesTop Allergens: Places Where They HideFood Allergies and Hospitals: Lack of Training and Reliable Systems

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Does the Drug Used in Anesthesia Contain Egg and Soy? - Allergic Living