Easy Remedies That Can Help Relieve Allergy Suffering – 24/7 Wall St.

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Easy Remedies That Can Help Relieve Allergy Suffering

Hristina Byrnes

As the world concentrates on fighting the COVID-19 pandemic, spring is fast approaching. Trees will soon be in bloom, spring flowers will decorate parks, and green grass will make everything look more pleasant. Most people cannot wait to see signs of spring. For the 50 million Americans who suffer from seasonal allergies, the sixth leading cause of chronic illness in the United States, excitement about spring is accompanied by a feeling of dread.

24/7 Tempo reviewed information by the American Academy of Allergy, Asthma and Immunology, and other health-focused sites to compile a list of ways to relieve seasonal allergies symptoms.

Spring allergies, which go by other names such as hay fever, or the more medical name such as allergic rhinitis, can cause sneezing, stuffy and runny nose, watery eyes, as well as itchy nose, eyes, and mouth, according to the American College of Allergy, Asthma and Immunology. These symptoms are due to an allergic sensitivity to pollen from trees, grass, weeds, or airborne mold spores.

An allergy is the immune systems hypersensitivity reaction to usually harmless substances in the environment. If the body is allergic to food, most symptoms occur around the mouth, throat, or stomach. If the allergen is something a person breathes in, the symptoms are then likely to affect the eyes, nose, and lungs here are 16 symptoms you may not know are allergic reactions.

Click here for easy allergy relief that isnt medication.

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Easy Remedies That Can Help Relieve Allergy Suffering - 24/7 Wall St.

When will a Covid-19 vaccine be available in New Zealand? – RNZ

Vaccines for Covid-19 could be at least 12 to 18 months away from wide distribution according to the world's leading scientists, but that doesn't mean they aren't moving at breakneck speed trying to develop them.

The timeframe of 12 to 18 months could theoretically be accelerated, but people must plan for at least an 18-month wait. Photo: RNZ / Samuel Rillstone

Right now there is no vaccine available for Covid-19 - a new coronavirus disease - which means that scientists around the world trying to develop vaccines are starting from scratch.

New Zealand's foremost experts in viral immunology are working closely together, and with other countries, to combine their knowledge and resources, yet Auckland University immunologist Rod Dunbar said people's expectations may need to be tempered.

"We all feel incredibly responsible to do all we can, however, in terms of our actual work, we are hesitant at this stage to share too much detail because we don't want to over promise," Dunbar said.

He said the timeframe of 12 to 18 months could theoretically be accelerated, but people must plan for at least an 18-month wait.

"You just can't predict what clinical trials are going to tell you, and early vaccines that aren't thoroughly tested can come with side-effects or potentially make the virus worse - so we have to be careful."

Graham Le Gros is the research director of the Malaghan Institute - a world-leading biomedical research institute based in Wellington - and fears 18 months may be a conservative prediction. Some vaccines can take more than a decade to safely develop.

"We really are blind on this one. I think 18 months is quite optimistic," he said.

"But it's just a virus. We'll get this thing. Obviously, it's a great challenge, but there are wonderful technologies now that means something will come up."

Trials around the world are slowly shifting into gear.

In Seattle this past week, 45 healthy volunteers began taking part in a six-week human trial against Covid-19, but it will be many months to know if this vaccine, or others in development, are effective.

But the good news is that Dunbar said vaccine development is far from resembling a "space race".

"There are some commercial imperatives, such as companies wanting to sell vaccines - so they won't share everything they know, but in terms of work being done targeting the virus, we're looking at an unprecedented speed and international collaboration. The fact that China has shared information has been incredible," he said.

"Information is being shared in academic publications, but without any barriers to access. There is a massive coordination effort."

He said the vaccine that comes first is likely to be the one that is both safe and effective, but also able to be "scaled up". In other words, which vaccine allows for the quick production of doses for massive global communities.

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Le Gros expects multiple different vaccines to be produced and distributed. Certain vaccines may only be effective for certain people. As of a week ago, the World Health Organisation's website listed 41 candidate vaccines in development.

His Malaghan Institute, which started to look closely at Covid-19 about three weeks ago, has applied for a grant from the Health Research Council and hopes to put together a programme of its own. The institute can assist in vaccine development via its ability to test on mice.

"We've been living for almost 100 years in some sort of vaccine-protected world and we haven't really had any infectious agents that we are completely susceptible to, like this, for a long time," he said.

There is research showing that those who recover from Covid-19 are protected from reinfection for a long time, although this assumption isn't yet backed by definitive evidence.

"The fact that there are reports that most people who are recovering are now well, is good, and those people are effectively super-charged against the virus," Dunbar said.

But even if infection rates drop, the importance of developing a vaccine is still crucial.

"We don't yet know enough about this virus - we may not have lifelong immunity - and that's why vaccines can be effective down the track. Viruses like these are designed to survive," Le Gros said.

"If the virus changes every year, we may end up having a coronavirus season every year and different immunity shots will be needed."

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When will a Covid-19 vaccine be available in New Zealand? - RNZ

Research interrupted: Lab groups find their way together – Cornell Chronicle

When Mariana Wolfner, a Cornell geneticist and molecular biologist,learned March 15she needed to suspend all noncritical research as part of the universitys effort to stem thecoronavirus outbreak, she had two main concerns.

The first was how best to help her students.

Everyone is just stunned ..., obviously because of the coronavirus, but also because of their research suddenly stopping or slowing down, said Wolfner,the Goldwin Smith Professor of Molecular Biology and Genetics in the College of Arts and Sciences (A&S). She has emphasized staying in contact with her lab virtually, to create a sense of community and support.

Ciro Cordeiro, a postdoc in Scott Emrs lab in Weill Hall, organizes frozen cell samples.

The other thing thats been hard has been trying to figure out what to shut down without forgetting something critical to maintain, said Wolfner, a Stephen H. Weiss Presidential Fellow.

She and other researchers on campus have found that people are making extra efforts to help each other.

Everyone is working together, pitching in to find solutions to problems as they arise, saidScott Emr,the Frank Rhodes Professor of Molecular Biology and Genetics in A&S and director of the Weill Institute for Cell and Molecular Biology. The atmosphere in the lab is very collegial and supportive.

With universities across the country also suspending research, scientists have offered transition strategies on social media. Students in Wolfners lab also consulted friends at other institutions.

Using that, weve come up with a plan, Wolfner said. Her students canvassed lab members to determine what experiments were absolutely critical. A postdoctoral researcher made a shift schedule for the lab.

Laura Harrington, a professor of entomology whose research seeks to understand mosquito biology and use that knowledge to prevent them from spreading disease, has noticed small but meaningful acts of kindness. Students have made their own hand sanitizer and made it available. Entomology graduate students circulated a list of people willing to provide a room in their homes for students who had no place to go.

I was really touched by people reaching out, she said.

Another major consideration for researchers has been what to do with stocks of animals or cultures that are invaluable for their research.

Avery August, professor of immunology and vice provost for academic affairs, said maintaining animal models used in his lab will be essential for when lab members return to work.

We work a lot with animals, he said, adding that animals used in research can take months and even years to develop. Along with maintenance, research animals must continue to be bred. A lab member will come in regularly to make sure the animals are cared for, so that we dont lose six to nine months if we just stopped everything, August said.

Harrington and her lab colleagues are in a race to complete an essential research project theyve been working on for the last two years, on the acoustic behavior of disease-carrying Anopheles mosquitoes, a key for understanding how males hone in on females for mating. Weve got a whole bunch of really valuable mosquito strains that we need to maintain, she said.

Wolfners lab does pioneering work with fruit flies, which must be maintained and bred. One students entire doctoral thesis is based on a strain of flies the student created. To keep all the flies alive, a team is working at the lab in shifts, so theres only one person in the lab at a time.

Perhaps the biggest task for faculty has been supporting and guiding students during this transition.

A lot of people are upset, said Colin Parrish, the John M. Olin Professor of Virology at the Baker Institute for Animal Health. The students are trying to figure out what theyre going to do to finish their research projects, finish their theses.

Postdocs in Scott Emr's lab in Weill Hall work to freeze down cell samples to preserve the labs research.

Parrish has been helping his students come up with solutions ways they can be productive remotely, read papers and write. One of his students who was scheduled to travel for a job interview will now be interviewing online.

Its been especially hard for senior undergraduate students, because they are graduating, Harrington said.

One of her seniors was upset she was not able to finish her honors project research. I just told her, Youve done the best you can with the lab work, but it really is the experience that is the educational component rather than the end product, Harrington said.

Emrs group held a pre-graduation ceremony and celebration March 17, complete with a decorated sheet cake with an inscription, for two graduating seniors who feared they wouldnt have a graduation ceremony.

A one-hour pause in our day that made us all feel good, Emr said, especially the two seniors in my lab who are likely saying a final goodbye to Cornell when they leave Ithaca in the next three days.

As people leave campus, most lab groups have plans to stay in touch via regular Zoom meetings. Wolfners group has already held a Zoom lab meeting where they discussed a journal article just to do something normal, and it made us relax, she said. They plan to meet virtually three times a week.

Harringtons lab had its first virtual meeting on March 16. We tried to laugh about things, you know, talk to each other and share ideas, support each other, she said.

As a community, everyones done a great job, Parrish said. People are doing what they can to make it a smooth transition, and hopefully, in a month or two, when things settle down, well be able to start moving things in the other direction.

Research and lab work are being scaled down across Cornell Universitys campus to stem the spread of COVID-19. In Scott Emrs molecular biology and genetics lab, postdoctoral associates are putting most research on ice.

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Research interrupted: Lab groups find their way together - Cornell Chronicle

Janssen Submits Ponesimod New Drug Application to the US FDA for Treatment of Adults with Relapsing Multiple Sclerosis | Small Molecules | News…

DetailsCategory: Small MoleculesPublished on Thursday, 19 March 2020 13:23Hits: 346

TITUSVILLE, NJ, USA I March 18, 2020 I The Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen) today announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for ponesimod for the treatment of adult patients with relapsing multiple sclerosis (MS).

Ponesimod is an investigational selective sphingosine-1-phosphate receptor 1 (S1P1) modulator that inhibits S1P protein activity and in so doing is believed to reduce the number of circulating lymphocytes that can cross the blood-brain barrier. In patients with MS, the movement of immune cells into the brain damages myelin, the protective sheath that insulates nerve cells. Damage to myelin slows or halts nerve conduction, producing the neurologic signs and symptoms of MS.i

"Nearly 1 million people over the age of 18 in the U.S. live with MSii, and approximately 85 percent of people with the condition are initially diagnosed with relapsing MS.iiiDespite new advancements and treatments coming to market, a number of unmet needs still remain leaving patients struggling to manage often-debilitating symptoms," said Mathai Mammen, M.D., Ph.D., Global Head of Janssen Research & Development, LLC. "In the coming months, we'll work closely with the FDA to bring ponesimod one step closer to the MS patient community and remain encouraged by its superior efficacy profile specifically in reducing new inflammatory lesions and disability accumulation in comparison to a leading therapy on the market."

The NDA is based on the head-to-head OPTIMUM Phase 3 study, which showed superior efficacy of ponesimod 20 mg on the primary endpoint of reduced annualized relapse rate (ARR), as well as most secondary endpoints, compared to Aubagio (teriflunomide) 14 mg in adults with relapsing MS.

At week 108, a highly statistically significant reduction of 30.5 percent on ARR was observed with ponesimod when compared to Aubagio. Additionally, a statistically significant reduction of fatigue symptoms and a 56 percent reduction on combined unique active lesions (CUALs) in the brain were observed with ponesimod compared to Aubagio. The safety profile observed for ponesimod was consistent with previous studies of ponesimod and the known safety profile for other S1P receptor modulators.

"What's interesting about MS is that symptoms are not always visible. Fatigue is one of the most common and debilitating symptoms of MS and yet, it's one of the most challenging to manage and treat," saidHusseini Manji, M.D., F.R.C.P.C., Global Therapeutic Area Head for Neuroscience at Janssen Research & Development, LLC. "We were thrilled to see improvement in fatigue-related symptoms as part of the Phase 3 OPTIMUM trial as we know the profound impact it may have on a person's daily life. The improvement in fatigue, coupled with reduction in ARR, demonstrate great promise for ponesimod with patients seeking a more targeted treatment option."

The clinical study data that supports this filing was presented in September 2019 at the 35th Congress of The European Committee for Treatment and Research in Multiple Sclerosis Conference (ECTRIMS) in Stockholm, Sweden. More information may be found here.

About Multiple Sclerosis (MS)MS is a chronic autoimmune inflammatory disease of the central nervous system affecting 2.3 million people worldwide,iv with females more impacted than males.v The disease is characterized by demyelinationii and axonal loss leading to neurological impairment and severe disability.vi Relapsing forms of MS, which make up 85 percent of all MS cases, include clinically isolated syndrome, relapsing-remitting MS and active secondary progressive MS.vii In addition to the debilitating neurological symptoms of the disease, patients often also suffer from "hidden symptoms," namely fatigue and depression, both of which are major contributors to the reduced quality of life.viii Fatigue is one of the most common symptoms of MS, occurring in about 80 percent of people.ix

Relapses are defined as new, worsening or recurrent neurological symptoms that last for more than 24 hours with the absence of fever or infections. Relapses may be fully resolved over days or weeks or lead to persistent residual deficits and accumulation of disability.x

About the Janssen Pharmaceutical Companies of Johnson & JohnsonAt Janssen, we're creating a future where disease is a thing of the past. We're the Pharmaceutical Companies of Johnson & Johnson, working tirelessly to make that future a reality for patients everywhere by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology, and Pulmonary Hypertension.

Learn more at http://www.janssen.com. Follow us at http://www.twitter.com/JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies of Johnson & Johnson.

*Aubagio(teriflunomide) is a registered trademark of Sanofi Socit Anonyme France.

iNational Multiple Sclerosis Society. What is Myelin? Available at: https://www.nationalmssociety.org/What-is-MS/Definition-of-MS/Myelin. Accessed July 22, 2019.iiNational Multiple Sclerosis Society. Multiple Sclerosis FAQs. Available at: https://www.nationalmssociety.org/What-is-MS/MS-FAQ-s#question-How-many-people-have-MS. Accessed November 20, 2019.iiiNational Multiple Sclerosis Society. Relapsing-Remitting MS (RRMS). Available at: https://www.nationalmssociety.org/What-is-MS/Types-of-MS/Relapsing-remitting-MS. Accessed February 12, 2020.ivNational Multiple Sclerosis Society. Multiple Sclerosis FAQs. Available at: https://www.nationalmssociety.org/What-is-MS/MS-FAQ-s. Accessed April 23, 2019.vNational Multiple Sclerosis Society. Who Gets MS. Available at: https://www.nationalmssociety.org/What-is- MS/Who-Gets-MS. Accessed April 24, 2019.viNational Multiple Sclerosis Society. Immunology of MS. Available at: https://www.nationalmssociety.org/What-is-MS/Definition-of-MS/Myelin. Accessed July 22, 2019.viiNational Multiple Sclerosis Society. What is MS? Types of MS. Available at: https://www.nationalmssociety.org/What-is-MS/Types-of-MS. Accessed July 22, 2019. viiiBiernacki T, Sandi D, Kincses ZT, et al. Contributing factors to health-related quality of life in multiple sclerosis. Brain Behav. 2019;00:e01466. https://doi.org/10.1002/brb3.1466. ixNational Multiple Sclerosis Society. Fatigue. Available at: https://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Fatigue. Accessed February 25, 2020.xMultiple Sclerosis Association of America. What is an MS relapse? Available at: https://mymsaa.org/publications/ms-relapse-toolkit/what-relapse/. Accessed July 22, 2019.

SOURCE: Janssen

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Coronavirus offers reprieve from air pollution | TheHill – The Hill

Environmental experts say the planet is getting a breather from the constant output of pollution by humans as the coronavirus puts many activities by individuals and businesses on hold.

Smog levels in China were reduced after factories shuttered during the outbreak there, and satellite images show a significant drop in air pollution in Italy while the country remains in a nationwide lockdown.

Similar declines are soon expected in the U.S., where half of all car trips are to and from work or school.

But while the coronavirus pandemic could disrupt daily routines for months, experts say the drop in heat-trapping emissions, while beneficial, will likely amount to just a blip in trend lines that show the world is moving toward unsustainable levels of carbon dioxide, or CO2, emissions.

The damage from CO2 just accumulates, so every ton we don't release is not inflicted on the environment, but if everything goes back to business as usual when this ends, it wont have much of an impact, said David Archer, a professor of geophysical sciences at the University of Chicago.

Experts say emissions are likely to drop this year, continuing a trend already driven by the closure of coal-fired power plants as utilities transition to cleaner forms of energy.

And as schools close and more Americans work from home, the decline in travel is likely to aid the emissions dip.

Vehicle emissions are expected to drop in the U.S. In New York City, traffic congestion was measured at 17 percent this week, compared to 52 percent during the same period in 2019, according to transit data company TomTom.

Air traffic, however, is a more complicated piece of the emissions puzzle.

Airlines have asked the federal government for $50 billion in economic relief amid massive declines in passenger travel as countries close borders, conferences are canceled and family vacations are postponed.

What counts is not the reduction in the number of people flying but the number of airplanes flying. There are a lot of airplanes running half empty, said Michael Gerrard, a professor at the Columbia Law School and director of the Sabin Center for Climate Change Law.

Many airlines are flying with planes that are anywhere from 30 percent to 50 percent full, whereas this time last year flights were about 80 percent full, according to information collected by Airline Data Inc.

While planes still account for just a small percentage of global emissions, the airline industry is one of the fastest growing sectors with greenhouse gas emissions. Emissions increased 32 percent between 2013 and 2018.

With more online meetings being held amid the outbreak, some clean energy advocates hope it could lead to a behavioral shift.

Weve seen a rise of fly-in, fly-out business travel, where 30 people come in and out, everyone shakes hands and then leaves almost immediately, said Dan Rutherford, aviation director at the International Council on Clean Transportation.

That's bad for the environment and now people are understanding it's bad for public health, so Im curious if that takes more of a long-term hit.

But data shows that airline traffic, while often taking a hit for about a year after events like 9/11 or the first Gulf War, eventually picks up again.

Similarly, many of the day-to-day human activities that have been put on hold by coronavirus are likely to resume once calls to social distance or shelter in place come to an end.

Are we talking about a short-term decline in emissions? Absolutely. It's not clear to me yet the epidemic will transform our economy to be more energy efficient or change human behavior, said Rob Jackson, an environmental scientist at Stanford University as well as chair of the Global Carbon Project.

Gerrard added that emissions have often gone down during recessions, only to recover alongside the economy.

I think we're talking about blips Im not sure whether theyre small blips or large blips but theres no reason to believe this is affecting overall trends unless it leads to a long-term crash of the global economy, which no one wants, he said of emissions.

There are also fears that an economic downturn might slow progress on some environmental fronts.

Companies ranging from Microsoft to Nestle have previously pledged to reduce their carbon footprint efforts Jackson worries may stall when faced with financial challenges caused by coronavirus.

It may hurt companies ability to keep their commitments; it may give them an excuse not to keep their commitments; it may make the government less likely to push more improvements too, he said.

Those scenarios suggest any long-term improvements to stem climate change are unlikely to come out of the coronavirus pandemic.

Its like were spending money on a credit card that we can't pay back every year, said Archer. If you stop spending for a year but then continue later, it slows down accumulation of the debt, but it doesn't make that much difference in the long run if your spending just bounces back.

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Coronavirus offers reprieve from air pollution | TheHill - The Hill

Now AI will get to know your intentions, scientists teaching the nuances of human behavior – westofthepond.com

Imagine that you have put a robotic machine in front of you and you can describe it in a word of mind.At first it seems like a small part of a film, but now it can also be possible in reality.Because scientists have started making such robotic machines.For this, they are also teaching the Artificial Intelligence (AI) system the nuances of human behavior so that machines can anticipate peoples intentions in a timely manner and give prior notice if anything is anticipated.

Researchers at the University of New South Wales (UNSW), Australia, said, In the era of growing AI, machines are now being built that have the ability to talk to humans and even detect their intentions.He said that currently AI can do commendable work to find out the intentions of a person.Apart from this, a possible list of different reactions of humans in a situation can also be made.From this it can be found out what kind of reactions a human being can give in a particular situation.

Human attachment to machines increases over time

Leila Yao, senior lecturer at UNSW, said, Over time, the attachment of humans to machines is increasing.Machines also think like humans and help to work, it is necessary that its system be further improved.With this, machines will not only be able to take better decisions but also forecast our intentions.

Yao said that in return for improving the AI system, it can increase our ability to work and make decisions.This will establish cooperative relations between machine and man and will be able to work well.Researchers said that although it will take some time to prepare machines that make 100 percent accurate predictions of human intentions, humans are not able to detect the frenzy in another persons mind.

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Now AI will get to know your intentions, scientists teaching the nuances of human behavior - westofthepond.com

UMMC experts give tips on dealing with anxiety and stress during coronavirus outbreak – WLBT

Dr. Daniel Williams, Division Chief in the Department of Psychiatry and Human Behavior and Associate Director in the Office of Well-Being says quote..."I dont have control over whether there will be toilet paper in the store. All I can do is make reasonable attempts to get it, and if worst comes to worst, come up with a plan B. He adds. when people dont have things, they get very creative. No matter what is upsetting you, your feelings are normal and nothing to be ashamed of.

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UMMC experts give tips on dealing with anxiety and stress during coronavirus outbreak - WLBT

Last Nights on Londons Stages, Before the Lights Went Out – The New York Times

LONDON Nol Coward wrote Blithe Spirit in a mere six days, and the perennially popular play opened on the West End in 1941, running for nearly 2,000 performances setting a record in London for a nonmusical.

Its longevity back then is in stark contrast with the most recent outing of the play here, with Jennifer Saunders, of Absolutely Fabulous fame, playing the bicycle-riding medium Madame Arcati, who communicates with the dead. A victim of circumstances beyond the control of even the most supernaturally minded, the director Richard Eyres comparatively somber revival played its last performance at the Duke of Yorks Theater on March 14; the run had been due to finish on April 11.

The production closed early after Londons West End theaters took coordinated action on Monday to close themselves down and help stop the spread of the coronavirus. Londons West End, like Broadway, has gone dark, and no one knows when the lights will come back on.

As premature closings go, the timing here was somewhat ironic, when you consider how audiences throughout World War II flocked to Blithe Spirit, Cowards inquiry into the frustrations, erotic and otherwise, of Charles (Geoffrey Streatfeild), a novelist whose first wife returns from the grave. (She died, were told, while recovering from pneumonia, which may well have had an eerie resonance for nervous playgoers today.)

When she rises up, the mischievous Elvira (Emma Naomi) scatters calculated chaos in her wake. Its giving nothing away to tell you that she ends up taking Charless second wife, the whiplash-tongued Ruth (Lisa Dillon, giving the performance of the night), over to the other side with her, though neither woman will go quietly from the land of the living.

This was easily the least buoyant Blithe Spirit Ive seen, which was presumably intentional on the part of Eyre, the distinguished director who once ran the National Theater. The trend of late has been to find in Cowards outwardly breezy plays something more psychologically acute, as was the case when Andrew Scott, of Fleabag fame, stormed the Old Vic last summer in Present Laughter. Against expectation, a character long presented as a devil-may-care narcissist was revealed to be an anxious man-child, as well. Both revivals remind us that Coward possessed a keen understanding of human behavior, in addition to a quick wit.

In this Blithe Spirit, Charles and Ruths marriage seems far from blissful well before Elvira arrives on the scene, and Eyre takes the verbal brickbats they lob at each other for real. This, like Present Laughter, is a Coward play centered around a man who draws women to him when he would rather be left alone: Both plays end with their flustered heroes fleeing female companionship, but for what precisely? Coward leaves the sequels up for grabs.

The fate of this show, however, is sealed though no one could have guessed how quickly it would flit from view. Think of the cast as the casualties of an invisible terror. It was one that Saunders, top-billed albeit in a supporting role that Judi Dench is playing in a forthcoming film, acknowledged when Madame Arcati a germaphobe before her time reacted in spontaneous disgust at shaking another characters hand. I doubt those who laughed at that gesture last week would do so now.

Across London last week, a city in gathering distress was met with theater that chimed with the prevailing mood. Before the shutdown, I caught what turned out to be the final matinee of Shoe Lady, an arrestingly quirky play from E.V. Crowe at the Royal Court Theater, best described as a surrealist nightmare in the style of Caryl Churchill.

Its like were all on the edge, says Viv, a realtor whose life goes into free-fall when she loses a shoe on the London Underground. Buck up, she says, all the while succumbing to a growing sense of anxiety, brilliantly captured by Katherine Parkinson, accentuating her characters panic the more determinedly she keeps smiling. Running just over an hour, Vicky Featherstones production cant have anticipated how much the play, which might otherwise have seemed a theatrical caprice, felt instead like a parable of precariousness in a society that, much like Viv, seems to be losing its grip.

The connection between life and art was even more keenly felt on Monday at the Southwark Playhouse, in southeast London, one of the few theaters to offer a show on the evening when the bigger houses around town were calling it quits.

There, I was among a surprisingly full house to catch the last performance of the director Jonathan OBoyles hyper-intense revival of The Last Five Years, the Jason Robert Brown musical about a couple falling apart. (Think of it as the Marriage Story of the early 2000s.) The conceit of a show that alternates perspectives across 90 minutes is that one character, Jamie (the excellent Oli Higginson), tells his version of events from the beginning, whereas his ex, Cathy (Molly Lynch), begins her version of events at the end.

But there was no doubt for those in the room that we were all witnessing a finish of a different sort, given that it is entirely unclear when any of us will find ourselves in a London playhouse again. The audience that night had seemed especially focused, as if everyone present was savoring for keeps the experience of live performance.

Taking an empty Underground train home, I couldnt help but feel that Jamie and Cathys unraveling had acquired a resonance well beyond what the composer-lyricist Brown could have imagined. I wont soon forget the surge of feeling throughout the auditorium when the show got to its closing sequence, and ended on a single word: Goodbye.

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Last Nights on Londons Stages, Before the Lights Went Out - The New York Times

Parkland chief: Past epidemics reveal why we must take serious action now – The Dallas Morning News

On Sept, 27, 1918, there were 15 cases of influenza reported in Dallas. The Dallas Health Officer, A.W. Carnes, underestimated the coming pandemic and allowed the Liberty Loan parade to proceed the following day. Thousands flocked to the streets in downtown Dallas. Eleven days later Dallas had over 1,000 cases of influenza. Three days after that the count was 2,719.

The subsequent responses to the 1918 flu pandemic will sound eerily familiar today. A tent was erected at St. Pauls Hospital to handle the overflow of cases. Baby Camp, a childrens hospital, restricted all visitors. Parkland turned a chronic disease ward into an isolation ward for influenza patients and recovering patients were moved to hallway beds to make room for newer admissions. On Oct. 10 theaters, playhouses and other entertainment venues closed. Two days later, Mayor Joseph Lawther closed schools and banned public gatherings including church services.

With cases skyrocketing the mayor acted reluctantly stating, I am taking this action not because the situation in our city is alarming but as a measure of safety and precaution and because it seems to be the desire of our citizenship.

Across the country leaders unwilling to acknowledge the reality at hand and reluctant to take action contributed to public mistrust. In Philadelphia, one of the cities hardest hit, Director of Public Health Dr. Wilmer Krusen was slow to respond. Described as someone who thought most problems disappeared on their own, Krusen lost the publics trust and that mistrust led to panic and selfish behaviors. When the Bureau of Child Hygiene begged neighbors to take in children whose parents had died, the response was silence. Pleas for volunteers to feed dying patients and for nurses to deliver medical care were ignored.

From a medical perspective, surprisingly little has changed in a century. Non-pharmaceutical interventions (NPIs) are still our first line of defense against the spread of COVID-19. Isolating known cases, quarantining family contacts, limiting social interactions, and closing schools are the tools we have available to us. These actions are similar to 1918 but our understanding is better. Unlike 1918, local authorities today are proactively proposing these personal and economic sacrifices in order to suppress the spread of COVID-19.

These interventions are designed to delay peak transmission to give the health system time to prepare; blunt the peak so the health system is not overwhelmed; and buy time for researchers to develop a vaccine.

The NPIs are tough medicine but a true anticipation of the threat before us. Honest communication and thoughtful actions build public trust that is critical as we call on each other to act as a community in service of each other.

In his epic story The Great Influenza, John Barry quoted Albert Camus: Whats true of all the evils in the world is true of plague as well. It helps men to rise above themselves. Barry went on however to warn, evil and crises do not make all men rise above themselves. Crises only make them discover themselves. And some discover a less inspiring humanity.

Stories of plague and flu pandemics often tell the stories of heroes who risked their lives to save their fellow humans. That history is also replete with acts of selfishness and abandonment. Often in retrospect we are not proud of the human behavior in these crises.

In the past two weeks I have heard the stories from across the country of stolen personal protective equipment (PPE) and workers who refuse to care for potentially infected individuals. But I have witnessed many more instances of health care colleagues understanding their risks, taking appropriate precautions and raising their hands to care for infected individuals. These caregivers are ministering with skill and compassion to the sick in full exemplar of their callings to serve. We are writing the story of our response by our actions today.

Be generous interpreting the decisions of leaders. Public health officials were criticized for an aggressive vaccination campaign in anticipation of the swine flu pandemic that never materialized in 1976. We can hope for something similar.

Inform yourself. The virus has mild clinical manifestations in 80% of those infected. Those infected with minimal symptoms, however, can spread the virus to the elderly and those with chronic illnesses who have a greater chance of severe, life-threatening disease. With proper precautions (including sufficient PPE, which is needed in greater supply) our health care professionals can remain protected so they can continue to provide compassionate care to those infected.

Finally, stay connected. We will likely be dealing with this for several months. Reach out to someone socially isolated and fearful. Pay attention to the poor and the marginalized who have historically been disproportionately affected by crises like this one. Unlike 1918, you can text, email, phone or FaceTime. Staying connected is important for each individuals and for societys mental health.

Dr. Fred Cerise is CEO and president of Parkland Health & Hospital System.

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Parkland chief: Past epidemics reveal why we must take serious action now - The Dallas Morning News

DAVID CHANCEY: March Madness and the hunt for Double Q salmon – Henry Herald

The coronavirus outbreak still has my head spinning. As health officials keenly followed COVID-19, March began with news of the first U.S. death, a man in Washington state. Also, the CDC reported the first possible outbreak at a long-term care facility in Washington.

After a rough February closing, March 1 news reported a stock market surge of 5.1%. The rebound didnt last as economic distress surged as well.

Adjusting to the time change as we began the week of March 9, we wondered what a week with a full moon and a Friday the 13th would bring. We soon saw the coronavirus apprehension snowball.

The sports world turned upside down as various leagues cancelled, postponed or rescheduled their seasons. School systems shut down. Even some May graduations are already cancelled.

As new developments unfolded daily, observing peoples reactions became a study in human behavior. First came denial and disbelief. We lived our lives as if we werent affected, thinking China is a long way from America. Then COVID-19 hit Washington state and steadily spread.

Denial turned to skepticism: The news media is creating hysteria and people are overreacting, or This is a conspiracy with a political agenda, or This whole virus-thing is overblown.

Then skepticism turned to fear as people bombarded stores. Toilet paper turned to gold. Hand wipes disappeared. As my March 15 birthday approached, I requested fried salmon patties for my special meal. Suddenly, I couldnt find Double Q Pink Salmon as I daily visited several groceries and discovered the canned meat aisles cleared. I struck out.

Fear turned to hysteria as shoppers acted like a blizzard was coming, packing parking lots, standing in lines waiting for stores to open, clearing out key items. It was each man for himself until stores set limits. One customer asked, Did I miss the memo that the world was going to end?

Now folks seem to be coping with this disruption, hoping for this crisis to pass soon and for life to return to normal.

This craziness gives new meaning to March madness and reminds us how uncertain life is. Fear, scarcity and an unknown future trigger a reaction like stockpiling.

Stockpiling is a means of exerting control in a situation that is out of control, said Jon Mueller, professor of psychology at North Central College in Napierville, Ill. We want to do things to gain control, he said, and hoarding supplies offsets our sense of helplessness.

Chris Elkins, chief of staff at Denison Forum, shared hes having a hard time.

Theres no certainty about how this virus will spread or whom it will impact. . . I have zero control of the stock market, the hoarding or peoples compliance to guidelines. I find this troubling and deeply disturbing.

The reality is, under normal circumstances, we are NOT in control, even though we want to be. The sooner we accept that reality, the sooner we can lessen our anxiety. How can we live confidently in a world thats going nuts?

First, replace fear with faith. Faith and fear cannot coexist. Either were fearing or were demonstrating faith. Satan uses fear to erode our faith.

In times like these, where do you turn? Asaph found himself in a crisis and wrote, I cried out to God with my voice . . . and He gave me ear. In the day of my trouble I sought the Lord . . . (Psalm 77:1, 2a). Look first to God.

Second, remember Gods presence. Deuteronomy 31:8 reads, And the Lord, He is the One who goes before you. He will be with you. He will not leave you nor forsake you; do not fear nor be dismayed. God is with us in this crisis.

Third, look out for others. Were in this together. Dont fight over toilet paper. Share the wealth. Check on your neighbors, especially the elderly. Remember its not just about you.

Fourth, shine brightly. Believers must let the world see us living unafraid, using good sense, exercising wisdom, but living as people of faith who trust in a God who is bigger than coronavirus.

I finally found my favorite brand, Double Q salmon, by the way, and got to enjoy my belated birthday treat. And it was delicious!

David L. Chancey is pastor, McDonough Road Baptist Church, Fayetteville. The church gathers at 352 McDonough Road, near McCurry Park. Join MRBC this Sunday for Bible study at 9:45 and worship at 10:55 a.m. Visit them online at http://www.mcdonoughroad.org. Order Chanceys new book The Day I Nearly Met Dolly: Tales of Faith, Family and a Few Homeruns on Amazon.

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DAVID CHANCEY: March Madness and the hunt for Double Q salmon - Henry Herald