The Coronavirus Fighter: ‘Science will get us out of this’ – 10News

LA JOLLA (KGTV) - We are battling an invisible enemy with COVID-19, but scientists will eventually defeat it.

One of the best virus fighters in the world is here in San Diego.

Dr. Erica Ollmann Saphire is an immunologist who once led an international effort to defeat Ebola. She is now directing another worldwide team to do the same to beat coronavirus.

"It's like the introduction of smallpox into the new world," Saphire says from an office outside her lab in La Jolla.

She's describing how native American's must have reacted during the 1500s when Europeans brought the smallpox pandemic into the new world. The emergence of coronavirus is as unusual to us today.

"When there's a spillover event, and it's something new to us, and we have no prior immunity, and we have no defenses, it tends to expand and explode," adds Ollmann Saphire.

The San Diego immunologist directs a worldwide consortium from here at the La Jolla Institute for Immunology.

Ollmann Saphire oversees a global team that operates in 50 labs on five continents. They're job it is to save the world -- they study the virus and find a way to defeat it.

"This is the most exciting area of science, and the tools, the strategies, and the collaborations that we have to move against something novel are incredible," says Ollmann Saphire. "The data sharing is unprecedented."

But the work takes time. It will be at least a year before a vaccine is created, maybe longer.

We asked Dr. Ollmann Sapher for her expertise about the warm weather theory. Does it slow the virus? She explains that viruses such as the cold and flu do have seasonal patterns.

"You are more likely to get infected with many things in January than you are in June," says Ollmann Saphire.

But she adds new emergent viruses such as COVID-19 are unpredictable, which could make warm weather ineffective. Staying at home and social distancing are most effective in preventing the spread and contracting the virus.

"If we've all been shut up in the spring and we go out and interact with each other in the summer, you can expect the virus is going to keep spreading and expanding," says Ollmann Saphire. "Until we have something that gives us immunity, we're not immune."

And then there is something called herd immunity. Essentially, if you have enough people who get the virus and recover, it creates something similar to a fire-break blocking the spread of the virus. But you would need about 200 million immune American's for that to be possible.

As of April 27, we know of about one million confirmed cases, maybe more.

"And if there are ten times as we don't know about that we do know about, that's maybe 6 million are immune as a guess. That's a long way to go between 6 million and 200 million."

And finally, we asked about a message of hope from a scientist's perspective. How will we find a way through this?

"Science is what is going to get us out of this," adds Ollmann Saphire emphatically.

The Coronavirus Immunotherapy Consortium (CoVIC) is a global partnership to accelerate discovery, optimization, and delivery of life-saving antibody-based therapeutics against SARS-CoV-2, and is supported by the COVID-19 Therapeutics Accelerator of the Bill and Melinda Gates Foundation.

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ROME Therapeutics Launches to Develop Novel Therapies for Cancer and Autoimmune Diseases by Harnessing the Power of the Repeatome – Business Wire

CAMBRIDGE, Mass.--(BUSINESS WIRE)--ROME Therapeutics, a biotechnology company harnessing the power of the repeatome in drug development, launched today with $50 million in Series A funding from GV, ARCH Venture Partners and Partners Innovation Fund. ROME was founded to discover and develop novel therapies for cancer and autoimmune diseases by leveraging new insights from the vast uncharted territory of the repeatome the roughly 60% of the human genome consisting of repetitive sequences of nucleic acids, known as repeats. Drawing on deep expertise in oncology, virology, immunology and machine learning, the ROME team has identified several promising drug targets and launched multiple discovery programs.

The overwhelming majority of industry drug discovery programs target the roughly 2% of the human genome which encodes for proteins. Repeats have long been dismissed as junk DNA. However, recent discoveries at this frontier of biology have made it clear that the repeatome is a rich and complex ecosystem. Among other elements, it contains the remnants of ancient viruses which have integrated into the human genome over time. In addition to being vital for embryonic development, these viral-like strands of genetic material are activated in times of stress and may play a significant role in driving diseases such as cancer, as malignant cells co-opt the repeats to facilitate their own survival and growth. These insights are the foundation of ROMEs pioneering work to discover and develop repeatome-based therapeutics.

ROME is led by CEO, President and Co-founder Rosana Kapeller, M.D., Ph.D., who incubated the company during her tenure as an entrepreneur-in-residence at GV, where she is currently a Fellow. In her previous role as founding Chief Scientific Officer at Nimbus Therapeutics, Dr. Kapeller led the companys initiative to apply advanced computational technologies to the design and development of novel therapeutics. Notably, she led discovery and development of a new class of acetyl-CoA carboxylase (ACC) inhibitors for NASH, later acquired by Gilead Sciences.

At ROME, we have set out a bold goal: To drive even the most difficult-to-treat cancers and autoimmune diseases into sustained remission, Dr. Kapeller said. Too many patients do not benefit from todays therapies, or experience only a partial response that quickly fades. We believe the repeatome holds the key to longer-lasting interventions. Our scientific founders together with our team have made excellent progress in exploring this uncharted territory and identifying promising therapeutic paths. With the support of our outstanding investors and advisors, were moving quickly to advance our therapeutic programs.

By targeting this uncharted territory, ROME has the potential to open up huge new stretches of the genome for drug discovery, said Kristina Burow, Managing Director, ARCH Venture Partners and a member of ROMEs Board of Directors. We are thrilled to be working alongside the ROME team as they seek to develop novel therapies for intractable cancers and autoimmune diseases.

Rosana has brought together some of the best minds in oncology, immunology, virology and machine learning to create a novel approach to harnessing the power of the repeatome, said Krishna Yeshwant, M.D., General Partner at GV and a member of ROMEs Board of Directors. We believe that ROME has the insights and expertise to turn cutting-edge discoveries in this field into an important new class of medicines, and were proud to continue working with Rosana and her team as they drive their programs forward.

Shaping the development of ROME

The scientific insights leading to the formation of ROME came from clinical oncologist David Ting, M.D., and computational biologist and theoretical physicist Benjamin Greenbaum, Ph.D.

Dr. Ting, who focuses on understanding RNA expression patterns in cancer, is the Associate Clinical Director for Innovation at the Massachusetts General Hospital Cancer Center and an Assistant Professor at Harvard Medical School. Dr. Greenbaum uses techniques from statistical physics, information theory and evolutionary biology to understand the interaction of tumors with the immune system and to explore virus evolution. He is an Associate Member of Memorial Sloan Kettering Cancer Center, where he is an Associate Attending Computational Oncologist and inaugural Program Leader in Computational Immune-Oncology.

Julius Knowles, a Partner at Partners Innovation Fund and a member of ROMEs Board of Directors, worked with the scientific co-founders on company ideation. ROMEs formation was driven and shaped by Ari Nowacek, M.D., Ph.D., a Principal with ARCH Venture Partners. ROMEs founding intellectual property comes from Massachusetts General Hospital and the Icahn School of Medicine at Mount Sinai, where Dr. Greenbaum previously worked and carried out foundational research.

A leadership team with deep expertise

In addition to Dr. Kapeller, ROMEs leadership team includes:

Supporting the leadership team is a world-class Scientific Advisory Board including experts in virology, immunology, oncology and genetics:

A veteran Board of Directors

ROMEs Board of Directors includes investors, business leaders and scientists with deep expertise in company formation and drug discovery and development:

About ROME

ROME Therapeutics is developing novel therapies for cancer and autoimmune diseases by harnessing the power of the repeatome vast stretches of uncharted genetic material that have long been dismissed as junk DNA. With several drug targets identified and multiple discovery programs underway, ROME is moving rapidly to leverage this new frontier in biology. To lead this exploration, ROME has assembled a team of world-class leaders across fields including oncology, immunology, virology and machine learning. ROME was launched in April 2020 and was incubated at GV, in collaboration with ARCH Venture Partners and Partners Innovation Fund. ROME is based in Cambridge, Mass. For more information, please visit http://www.rometx.com.

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Secarna Pharmaceuticals Enters Into Cooperation with Guangzhou’s Sun Yat-sen University to Develop a Treatment for SARS-CoV-2 Viral Infections -…

MUNICH/MARTINSRIED, GERMANY / ACCESSWIRE / April 28, 2020 / Secarna Pharmaceuticals GmbH & Co. KG ("Secarna"), a biopharmaceutical company focusing on the discovery and development of next generation antisense oligonucleotide (ASO) therapies to address challenging or previously undruggable targets via its LNAplusTM platform, today announced that the Company has entered into a cooperation with the First Affiliated Hospital at Guangzhou Sun Yat-sen University (SYSU) for the development of a treatment or prophylactic for SARS-CoV-2 viral infections. Under this agreement, Secarna will employ its proprietary LNAplusTM platform to develop antisense oligonucleotides (ASOs) which specifically suppress the expression of a certain host factor that is essential for the viral infection cycle.

Secarna's approach to target host factors is beneficial compared to other approaches targeting the virus directly, as most viruses are known to evade targeted therapies by mutation over time. This risk could be completely avoided by targeting host factors. Additionally, different viruses often depend on common host factors. Therefore, a therapy addressing a host factor linked to existing or emerging viruses could potentially also serve as a treatment against future challenges.

The feasibility of Secarna's concept was already successfully demonstrated in 20191. In this study, Secarna employed its LNAplusTM platform to develop ASOs targeting the host factor NPC1 to efficiently reduce Ebola virus infection in vitro. The approach's applicability to SARS-CoV-2 is currently being evaluated by Prof. Claus Bachert at the University of Ghent in Belgium and the First Affiliated Hospital at Guangzhou Sun Yat-sen University (SYSU).

"We are very excited to be working together with Guangzhou's Sun Yat-sen University and leveraging our proprietary technology to develop LNAplusTM-based ASOs to potentially tackle SARS-CoV-2 infections. By targeting a host factor essential to the viral infection cycle, we hope to prevent the infection of cells and viral spread," said Jonas Renz, Managing Director and Co-founder of Secarna Pharmaceuticals.

Prof. Claus Bachert added: "This international cooperation is combining an innovative development platform with specific translational laboratory skills and the access to patients in a unique way."

About Secarna's proprietary drug discovery platform, LNAplusTM

Secarna's proprietary third-generation antisense oligonucleotide (ASO) platform, LNAplusTM, which encompasses all aspects of drug discovery and pre-clinical development, enables the company to discover novel antisense-based therapies for challenging or currently undruggable targets.Secarna's platform and ASOs have previously been validated by numerous in-house projects as well as in several academic and industry collaborations. With over 15 development programs focusing on targets in indications such as immuno-oncology, immunology, ophthalmology, as well as viral-, neurodegenerative- and cardiometabolic diseases, where antisense-based approaches have clear benefits compared to other therapeutic modalities, Secarna is the leading independent European antisense drug discovery and development company.

About Secarna Pharmaceuticals GmbH & Co. KG

Secarna Pharmaceuticals is the next generation antisense oligonucleotide (ASO) company with multiple innovative antisense therapies in various stages of pre-clinical development in the areas of immuno-oncology, immunology, ophthalmology, as well as viral-, neurodegenerative- and cardiometabolic diseases. Secarna's mission is to maximize the performance and output of its proprietary LNAplusTM antisense oligonucleotide discovery platform, as well as to develop highly specific, safe, and efficacious best-in-class antisense therapies for challenging or currently not druggable targets. http://www.secarna.com

Contact

Jonas RenzManaging Director and Co-founderJonas.Renz@secarna.com

Secarna Pharmaceuticals GmbH & Co. KGAm Klopferspitz 1982152 Planegg/MartinsriedTel.: +49 (0)89 215 46 375

For media enquiries:

Anne Hennecke/Vera LangMC Services AGsecarna@mc-services.euTel.: +49 (0)211.52 92 52 22

[1] Sadewasser A, et al. "Anti-Niemann Pick C1 Single-Stranded Oligonucleotides with Locked Nucleic Acides Potently Reduce Ebola Virus Infection In Vitro." Molecular Therapy Nucleic Acids, vol. 16, 2019, pp. 686-697.

SOURCE: Secarna Pharmaceuticals GmbH & Co. KG

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Hunter Library continues to assist faculty, students with virtual research, including 3D anatomy – Western Carolina University News

When Ashley Hyatt, assistant professor of physical therapy at Western Carolina University, recently needed to show her students various perspectives of the human brain, there was a challenge.

Normally, Hyatt teaches from a classroom, in the laboratory and using clinical demonstrations. But in this case, she was faced with the new normal of COVID-19.

No problem. Enter the staff and resources of Hunter Library.

Jill Ellern, associate professor and IT systems librarian, had obtained Organon Virtual Reality anatomy atlas software earlier in the semester, just before spring break. Students share video game play all the time with websites like Twitch, Ellern said. Making on-demand videos of educational topics seemed like it would be a great service we could provide to the faculty and students.

Following trial runs and discussion with faculty, Ellern and Hyatt were ready to put the application into use.

Jill and I did a recorded Zoom session while she removed parts of the brain in virtual reality, so we could show the students a three-dimensional perspective of the basal ganglia, Hyatt said. I did the voice-over while she did the step-by-step dissection, so students were getting a good description of the parts from different angles, very much like they would with an anatomic model in the lab.

Jill Ellern enters the virtual realm.

Although the Hunter Library building is closed to the public, the staff are still performing duties while practicing COVID-19 precautions, and are available to respond to many faculty and student requests for educational and research materials needs. The 3D example Hyatt and Ellern utilized fulfilled course requirements.

Dr. Hyatt always goes above and beyond when it comes to educational experiences, but I was absolutely blown away when half-way through the lecture, a virtual reality clip of a simulation of the brain in a lab appeared, said Bianca Boieru, a first-year doctoral student in the physical therapy program. With me being more of a visual learner, I highly valued our time in the anatomy lab. With our educational transition moving from face-to-face lecture to the online format, she found a way to give us back a piece of that experience. With something multi-layered and unique like the anatomy of the brain, the virtual reality simulation helped me visualize better than I could from any 2D textbook. Im grateful for this type of technology that helps give students back the experience of being in the anatomy lab.

Another participating student readily agreed. Being able to see such a complex structure, like the brain, in 3D has greatly contributed to my understanding of the location and orientation of structures within the cerebrum, said Abby Murrell, also a first-year doctoral student in the physical therapy program. I feel very fortunate to have faculty and resources that optimize learning even from an online platform.

Physical therapy students must undergo a great deal of advanced instruction and experience with human anatomy in order to give their future patients the best possible care, said Ann Hallyburton, the librarys liaison to the College of Health and Human Sciences.

The use of virtual anatomy tools in remote physical therapy education will hopefully aid students and their professors in these interesting times when access to the laboratories and other hands-on experiences with anatomical study have been made so challenging, Hallyburton said. In addition to the interactive, illustrative model-based learning provided by the 3D Organon tool, Hunter Library has also temporarily made available to students the Aclands Video Atlas of Human Anatomy, an electronic resource offering exploration of real human cadaver-focused anatomical instruction with a special emphasis on the mechanics of body movement, and McGraw-Hill Medicals AccessPhysiotherapy, an electronic resource melding physical therapy electronic textbooks, videos and self-assessments.

These tools join the librarys permanent access to Informas Anatomy.tv that offers interactive 3D models of human anatomy, numerous electronic research databases and journals, and the services of an experienced librarian who provides research assistance via Zoom, email, chat and telephone, Hallyburton said.

Hunter Library has always supported the early stages of the research lifecycle, said Sarah Steiner, associate professor and head of instruction services. Whether selecting a topic, narrowing or broadening that topic, then finding, evaluating and synthesizing credible sources on that topic. With the Scholar Studio, we aim to close the loop on the research lifecycle by helping faculty and students to create multimedia research and scholarly projects.

The library also offers a mobile application that provides for easy access to online resources and services. In addition to providing a digital library card, the app allows users to check library hours, reserve study space, search databases, browse the catalog to request materials, and manage their account by reviewing due dates and renewing items. The app works for smartphones and tablets, and can be found under WCU Hunter Library through the App Store for iOS devices or Google Play for Android devices.

In addition to the VR anatomy lab and online platforms, the traditional book loan and checkout process remains available, with a staff member getting the physical item to a patron outside of the building.

Hunter Library is one of the few libraries in the University of North Carolina System that did not cancel any of the services to students and faculty, said Farzaneh Razzaghi, dean of WCU library services. Our dedicated staff and librarians answer questions through chat, email and phone, borrow materials from other libraries and, if a journal is available, scan the articles and email them to students and faculty. We also check online requests for physical materials that are included in our collection.

For information, visit library.wcu.edu.

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Anatomy of a Hat Trick: How Gustav Nyquist and Zach Werenski Put Three in the Back of the Net | 1st Ohio Batte – 1st Ohio Battery

There have been 39 hat tricks by Blue Jackets players in the 19-year history of the franchise.

Two were added this season; one apiece from Zach Werenski and Gustav Nyquist. Werenski had 20 goals when the NHL season was suspended, which led all defenseman and was one behind Oliver Bjorkstrand for the club lead. Nyquist came into the COVID-19 suspension with 15 goals on the year.

Let's take a look at each of their hat tricks from this season, and what transpired to make them possible.

On November 29th, the Pittsburgh Penguins came to town for what is always a testy, adrenaline-filled battle. Nyquist scored the Blue Jackets' first, third, and fifth goals of the game in what was a fantastic contest.

Just five minutes in, Nyquist notched his first goal: a perfect example of Nyquist putting himself in a good position and making things happen, as he deflects Bjorkstrand's shot past Penguins netminder Tristan Jarry.

Then, with the Blue Jackets leading 2-1 early in the second period, Nyquist grabbed his second on the power play. Pierre-Luc Dubois drew two defenders along the wall, threw the puck out and found Nyquist, who drove to the net and buried a backhand to give the Blue Jackets a 3-1 lead.

The Penguins put together a push in the third period, but that was promptly shut down when Nyquist notched an empty-netter to put the game to bed with 59 seconds remaining. Josh Anderson cleared the puck out of the Blue Jackets' zone, and Nyquist won a footrace against Kris Letang to negate the icing call. All he had to do after that? Just tap it in.

It was a great night for Nyquist and the Blue Jackets, as they took two points from the Penguins and improved their record to 11-10-4.

Just over a month later, the Blue Jackets had a New Year's Eve date with the Florida Panthers. Old friend Sergei Bobrovsky made his first start against his former club, butZach Werenski ensured that the Pantherswouldn't leave Columbus with any points.

Just like Nyquist's hat trick, Werenski scored his first goal roughly five minutes into the game. Alexander Wennberg won a faceoff in the offensive zone, and the puck went directly to Werenski.The Blue Jackets' stalwart defenseman wasted no time rifling a slapshot past Bobrovsky.

Then, with just over four minutes gone in the third period, Werenski struck again. David Savard found him in space, and this time he uncorked a wrister that beat Bobrovsky low glove side. The Panthers would challenge the play for goaltender interference, believing Bobrovsky was bumped, but the call on the ice of a goal was confirmed after video review.

Four minutes later, Werenski gave the Blue Jackets a three-goal cushion. Nyquist, Boone Jenner, and Nick Foligno had a fantastic shift in the offensive zone leading up to the goal. Nyquist stole the puck from Mike Matheson behind the net, and then the three connected several passes while cycling the puck. Eventually, a pass from Nyquist deflected off of a Panthers defenseman and fell to Zach Werenski in an area that Werenski rarely misses from.

This game may have been the turning point for the Blue Jackets' season. Elvis Merzlikins defeated Bobrovsky for his first NHL win, and the Blue Jackets went on to go 9-2-0 in their next 11 games after this one, in large part due to the play of Merzlikins and Werenski.

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The anatomy of a coronavirus conspiracy theory – The Week

Most conspiracy theories have some sort of basis in historical fact. The CIA really did have a mind-control program. The FBI knew more about Lee Harvey Oswald than it let on to the Warren Commission. The planes that smuggled guns into Nicaragua were also smuggling drugs out of Nicaragua. We frequently uncover secrets about the U.S. government that make the wilder conspiracy theories sound more plausible.

But it is hard to draw a line from the U.S. government's coronavirus response to the conspiracy theories circulating about that response. Conspiracists believe the pandemic, or "plannedemic," is a coordinated effort to hold American citizens hostage and institute martial law. They warn that sheltering-in-place and social distancing are not temporary measures but instead will become the new normal. The government will require us to receive some sort of "digital tattoo" or microchip implant before we are allowed to leave our homes and go back to work. And eventually, the conspiracists claim, there will be a mandatory rollout of tainted vaccines concocted by the same mysterious forces that concocted the "COVID-1984" virus: vaccines that will render us infertile, docile, or dead.

How does this square with the federal government's documented actions? If anything, the government has been guilty of downplaying the threat posed by the virus, not exaggerating it. They have demonstrated a grievous lack of planning for this supposed "plannedemic." And rather than attempting to parlay the temporary economic lockdown into something more permanent, the president is eager to end it as soon as possible, so the stock market can go up and unemployment can go down in time for his re-election. When protesters around the country demanded that the economy reopen, Trump didn't call them enemies of the state; he celebrated them. If the Trump administration's secret goal is to provoke mass hysteria, shut down the economy permanently, and cancel democracy, it is not doing a good job.

There are other narratives being spun about the coronavirus which at least have greater internal logic. Small-government conservatives at outlets like The National Review and the Wall Street Journal argue that, yes, the federal government's response has been weak and this is a good thing. They champion what corporations, nonprofits, and state and local governments are doing to combat the virus. Where conspiracists see the ascendance of tyranny, many conservatives see a vindication of capitalism and federalism.

Meanwhile, traditional nationalists like Tom Cotton, Josh Hawley, and Steve Bannon see the pandemic as a chance to vilify China and the World Health Organization. They call for greater national autonomy and stronger border control, which have indeed been the clearest aspects of the White House's coronavirus response. Conspiracists, however, are less interested in vilifying China, which they see as a pawn in a greater scheme. They frequently claim the pandemic is a hoax, in which case border control would be irrelevant.

There are at least two explanations for this dissonance between the conspiracist imagination and the federal government's actual policies. One is that we may be witnessing the decline of "fusion paranoia" and the repolarization of conspiracy theories, so that conspiracists no longer denounce the government per se. Another is that the real source of conspiracist angst isn't the government, but rather the citizens who are willingly giving up their freedom.

The term "fusion paranoia" was first coined by journalist Michael Kelley in 1995, as the conspiracy theory movement was becoming an increasingly baroque fusion of the left- and right-wing fringes. This was a distinct break from the Cold War, when conspiracy theories were more ideologically contained. Right-wing conspiracists focused on the threat of communism, while left-wing conspiracists focused on the anticommunist right.

These Cold War conspiracists did not fear the government itself, but rather cabals working to subvert the government. Conservatives defended the State Department while they decried the communists who had infiltrated it. Liberals castigated the military-industrial complex while they propped up John F. Kennedy as a martyr, ignoring his record as a foreign-policy hawk. The big revelation in the Watergate-era thriller Three Days of the Condor wasn't that the CIA was crooked; it was that there was "another CIA in the CIA."

With the fall of the Soviet Union, ideological battle lines blurred. Alex Jones became an Austin counterculture darling, while Gore Vidal wrote a glowing Vanity Fair profile of fellow anti-imperialist Timothy McVeigh. White nationalists co-opted black nationalist accounts of the crack epidemic; religious skeptics cribbed from fundamentalist Christian tracts claiming barcodes were the sign of the Beast; self-identified liberals counted the Clintons' murder victims, while conservatives parsed through George H. W. Bush's 1990 speech proclaiming a "new world order."

Conspiracism was no longer tethered to any partisan ideology, no longer caught up in the cat-and-mouse game of communist vs. anticommunist. As Kathryn Olmsted explains in her history of conspiracy theories, the postCold War left and right "found a common enemy to fight in their defense of the republic: their own government."

But the election of Donald Trump may have repolarized our paranoia. Jones, who was no more a fan of George W. Bush than he was of Barack Obama, firmly believes Trump is on his side. When he lists the members of the plot to weaponize the coronavirus, he includes the "blue cities" and "blue states," Hollywood and the mainstream media, the universities, the medical industry, communist China but he leaves out the Trump administration.

Rather than blaming the U.S. government for unleashing the virus and shutting down the economy, right-wing conspiracists blame "the globalists" working inside and outside the government. Ben Garrison, the "alt-right's favorite cartoonist," portrays Trump in the backseat of a car, asking, "Are we there yet?" (i.e., when can the economy restart); sitting up front are his public-health advisers Anthony Fauci and Deborah Birx, who syly grin and respond, "In a few more months!... Maybe." Like Oliver Stone's JFK, Trump is trying his best but is undermined by sinister forces outside his control.

Bill Gates looms oddly large in these paranoid narratives Jones and Roger Stone believe the Gates Foundation manufactured the coronavirus, and in Garrison's cartoon Birx is wearing a Gates Foundation button. Another Garrison cartoon has Bill Gates (looking rather like a Protocols-esque Jewish caricature) unrolling a scroll that lays out his coronavirus plot: Stage 1 is "fear," Stage 3 is "shutdown and social distancing," Stage 5 is "martial law and checkpoints," and the last stage ("Stage 666") is the "mandatory vaccine rollout."

Gates is singled out not just because of his enormously wealthy foundation that has spent hundreds of millions on fighting the virus, but also because of his history as a software developer. Conspiracists frequently tie the "plannedemic" to the allure of new technology, from 5G mobile networks to VR headsets, because they fear that the seductiveness of technology is the New World Order's model for controlling all aspects of life. The globalists "seduced and beguiled everyone," Jones claims, with an "extended spring break" and "nice big juicy checks." The endgame is for everyone to be "put into our little bubbles, our little pods," where you have to get permission from an app to leave your home conveniently enabled by Microsoft, Apple, and other tech companies.

Conspiracists fear this plot will succeed if American citizens let themselves be manipulated. Jones calls our efforts to flatten the curve staying inside, washing our hands, wearing masks, meeting people on Zoom, keeping six feet from each other at the grocery store "little rituals" of "submission," and we must stop performing them if we want to be free. Popular podcast host Joe Rogan, who is less of a conspiracy theorist but is certainly conspiracy-curious, laments that "people are willing to give up certain civil liberties if they think they can get more safety." And while he concedes this is necessary for the time being, he asks, "what if it just sorta stays that way?" What is the price of our submission?

Jones explains the choice Americans face with a bizarre, violent, lowkey-racist allegory: imagine you stop at the grocery store "on your way back home from church on a Wednesday night," and as you return to your car, a couple of "thugs pull knives on you" and ask for "everything you got" and start coming on to your wife. Jones says you can let the thugs tie you up and take you to your house, where they'll get the codes to your safe, violate your wife, and "kill you while you cry." Or, Jones posits, you can "explode" in the grocery-store parking lot, "rip the knife out the guy's hand, and stab it right into his throat." This is analogous to our current situation, he insists, with the globalists standing in for the thugs: "You are under lockdown, you're under martial law. And it's just gonna get worse the more you submit to it."

Conspiracists are drawn to this fantasy of domination and submission because they refuse to accept that people are willingly surrendering their individual autonomy for the common good. Americans are looking out for each other, staying home even when they're not especially at risk, and calling on the government to take care of their basic needs. No one is drawing a knife on us.

This is too much for the conspiracist to bear. Their libertarian worldview is seemingly repudiated by the fact that, when faced with such a serious crisis, Americans are, by and large, not behaving like libertarians. It is easier for conspiracists to believe the pandemic is a globalist plot to brainwash us than to believe that Americans will give up certain freedoms with little if any pressure from any government or cabal that a little bit of peer pressure and genuine selflessness is all it takes. Behind the fear of a conspiracy, behind the fear that citizens will be easily duped, is a greater fear: that no conspiracy is necessary.

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Inside the Jefferson medical archives, where the most popular item is 1840’s ‘Anatomy of the Breast’ – Billy Penn

Philadelphia is home to the ninth oldest medical college in the United States and the fascinating archives that come with it.

Founded in 1824, Thomas Jefferson University has maintained a wealth of records. Most impressively, many of them are digitized. Staff have worked since 2005 to upload materials to an accessible and searchable online repository.

Thats the most exciting part, is to discover it for yourself, university archivist F. Michael Angelo told Billy Penn. We saved almost everything. Its a really rich collection, very detailed, very complete.

That means in quarantine, you can peruse centuries of health records totally free.

You wouldnt be alone. I suspect were getting new audiences now, Angelo said. Weve been getting more emails and phone calls asking questions, especially about genealogy.

The archives contain leads into stories about all number of topics, from war history to womens rights to scandals over racist body snatching. The most popular item? Look no further than an 1840 text on the anatomy of the breast.

Read on for a few highlights to get you started.

If youre interested in what its like to perform emergency medical procedures under extreme duress, look to the Civil War.

There are dozens of records on military surgery from the 1850s and 60s, when Jefferson doctors were overwhelmed with wartime injuries. The documents cover surgical technicalities, descriptions of emotional strife, and notes about the importance of medical professionals on the battlefield.

In the 1861 book A Manual of Military Surgery, Jefferson surgeon Samuel Gross wrote:

No men of any sober reflection would enlist in the service of their country, if they were not positively certain that competent physicians and surgeons would accompany them in their marches and on the field of battle, ready to attend to their diseases and accidents.

A dark spot on Jeffersons history is its sexist legacy. The Philly medical school was among the last in the country to start accepting women as students, according to Angelo, the archivist. But at least the experiences of these female pioneers were well recorded.

They did a really nice job interviewing some of those in the very first class of women, from 1961 to 1967, Angelo said.

There are about a dozen recorded interviews with women who graduated in Jeffersons first few integrated classes with audio files and written transcriptions available online.

Nancy Szwec Czarnecki tells her story as the first woman ever to graduate from Jeffersons medical school. Theres also Bonnie Lee Ashby, who later moved onto an infectious disease fellowship at Lankenau.

Anita Robinson first attended grad school at Penn but then realized she wanted to practice medicine first hand instead of research it. Shes still working in Philadelphia as a specialist in adolescent medicine.

Over the past 200 years, Thomas Jefferson University has graduated more than 46,000 medical students. By Angelos estimation, if your fam has been in Philly awhile, youre likely to find someone you know in their diploma records.

Somebody in Philadelphia who has an interesting last name probably can look in the directory and find forebears with the same last name, Angelo said. The odds are pretty good.

Here are the steps to find someone:

If youre lucky, you could find past work of someone related to you or your friends, and perhaps even find their signature in one of the university ledger books.

For those who like to confront their own mortality, searching the Jefferson archives for the word dissection will yield a whopping 1,177 results.

If you choose to click, many of them reveal pics of white men with handlebar mustaches, crowded around medical tables. Sometimes its dozens of people watching, sometimes just a few. Some of the bodies theyre observing have been resorted to skeletons, while some look mostly normal.

In the 19th century, it was tough to find cadavers on which to practice, and the college was at one point entangled in a scandal over body snatchers who raided Black cemeteries and sold disinterred bodies for $8 apiece.

Especially considering the provenance of whats on the table, the pictures are super interesting. They also reveal the evolution of popular facial hair choices of Phillys medical types over the years.

Keep your inner preteen boy from giggling if you must, but its true. The most popular item in the archives has to do with female anatomy.

According to Jefferson archivist Angelo, Anatomy of the Breast by Sir Astley Cooper has been downloaded more than 20,000 times and surpasses any other archive document in number of views.

I have to wonder how many of those downloads are because it has the word breast in it, Angelo said. Still, its a really cool item.

Though the thing was written in the 19th century, its still super accurate among the most accurate drawings of breast anatomy in the history of medicine, Angelo said. So its popular among medical students and researchers and yes, prob some internet trolls, too.

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Inside the Jefferson medical archives, where the most popular item is 1840's 'Anatomy of the Breast' - Billy Penn

Every Season of Grey’s Anatomy, Ranked – Glamour

To an outsider, Greys Anatomy is simply an ensemble medical drama about the lives and loves of (good-looking) doctors and surgeons at a prominent Seattle hospital told through the lens of surgeon Meredith Grey (Ellen Pompeo) as she rises in the ranks from intern to resident to attending. Real fans, however, know that Greys Anatomy is actually an emotional torture device overseen by the brilliant and sadistic Shonda Rhimes, an agonizing exercise in grief and loss delivered in weekly installments.

Greys Anatomy is about what makes us human: our blood, tissue, and bone, as well as our hearts, souls, and minds. Its about creating characters that feel so real, you cant help but come to care about them, and then either killing them, everything they love, or both. Greys Anatomy is nothing short of evila scourge, a blight upon our souls. So, obviously, its a massive hit that has been running for a decade and a half, attracted a wide and loyal fanbase, and made everyone involved insanely rich. It even spawned two spin-off series, Private Practice and Station 19.

Ranking all the seasons is sort of an impossible undertaking, since the dynamics and cast are always shifting. Heck, the name of the hospital changed from Seattle Grace to Seattle Grace Mercy West to Grey Sloan Memorial. Theres an argument to be made that everything before Derek and Meredith get together for good is one show about falling in love with your married boss, everything during their marriage is another show, and everything post-Derek is a third still-unclear premise for the series. And depending on a viewers loyaltiesto a particular character or relationshipeveryone has their own idea of when the show was at its best and worst.

With all that in mind, this is an attempt to corral the many, many, OH SO MANY, hours of Greys Anatomy into a ranking based on which plot lines felt the most random, forced, or arbitrary versus the ones that we simply couldnt look away from. From worst to best...

I have zero medical training, but this season made me scared for all of the hospitals patients. What the hell are the doctors doing? Practicing medicine on each other just to be cool, getting hyper-competitive over surgery assignments, going out of their specialties to shake things up and try to boost their rating? This is the season that the ceiling collapses on someone in the middle of surgery. Sorry, but I cant invest in any of the personal stuff unless Im also confident that the sick people are receiving at least competent care.

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Every Season of Grey's Anatomy, Ranked - Glamour

Justice League Anatomy: The 5 Weirdest Things About The Flash’s Body – CBR – Comic Book Resources

Just because they break so many laws of physics doesn't mean the Flash writers don't care about science. Quite the contrary, the "Flash Facts" section of the classic Silver Age Flash comics always went out of their way to try to explain just how the Scarlet Speedster's powers worked and just what happens to a body under the super-speed conditions he so often finds himself in.

The result is a whole lot of pseudo-science and it actually makes a lot more sense than one might think. The human body just wasn't built to go at the near-light speeds, but theFlash is no ordinary human. On top of the Fastest Man Alive, he could be the Strangest Man Alive. Here are the five weirdest things about the superhero's anatomy.

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There's a whole lot more to the Flash than just being able to run fast. The same way super-strength might come with making super jumps or super throws, moving extremely fast comes with a whole host of other powers that don't immediately come to mind. The Flash can create whirlwinds by spinning his arms, run across the surface of water and even phase through solid objects.

By vibrating the molecules of his body extremely fast, the Flash is able to "slide" his molecules through thoseof other solid objects. It's an extremely difficult move for a speedster to master and often comes later in the Flash's career, whenever a new hero takes up the mantle. Flash's vibrational abilities show just how thorough he is -- it's not just his legs that are fast, it's his everymolecule.

RELATED:DCAU Flash Vs DCEU Flash: Who Is Better?

If Flash's super speed goes down to the level of his molecules, it must affect every aspect of his body -- even his brain. Flash's neurons fire at incalculable speeds, allowing him to enter a mental state in which time appears frozen and he can work through complex problems in mere moments. Just imagine having a million thoughts a moment piled on top of sensory data from the environment. This ability served Barry Allen extremely well as a forensic scientist, allowing him to analyze the minutiae of a crime scene with a glance and then process all the data with his verifiable super computer of a brain.

Flash most often needs to activate the ability, but there is a subconscious level on which his instincts can kick in to protect him. Since he is unconsciously processing all that information at every moment, even the slightest shift in air pressure can tune him in to a potential threat. Call it a "Speedster Sense" or a "Barry Tingle," but it's proved to be one of the hero's most valuable abilities. Since he's too fast for most villains to touch, they will often try surprising him before he knows he's in a fight -- but that's a lot easier said than done.

RELATED:X-Men Anatomy: The 5 Weirdest Things About Juggernaut's Body, Explained

Onecan only go so far into the science of discussing the Flash before it's an absolute necessity to discuss the Speed Force. Conceived as a way to explain many of the more physics-breaking aspects to the Flash's powers, the Speed Force is an extradimensional power source which both fuels and protects all the speedsters of the DC Universe. The Speed Force it the answer to almost any question that asks how something a speedster can do is even possible. One of the most potent examples is friction.

Any object moving as fast as the Flash would necessarily generate a lot of heat as the molecules of the moving object bounce against the surrounding air or the ground beneath. That heat should incinerate the clothing and even the skin of someone moving so fast, but the Speed Force generates a protective envelope around the Flash and anyone he is touching that keeps them safe from harm. The same holds true for the air that presumably blasts into the Flash's eyes, which explains why he's one of the few speedsters who doesn't need goggles.

It's clear at this point that every aspect of the Flash moves far faster than a normal human and that holds true even for his metabolism. The most common example of his super metabolism is his appetite, as the Flash constantly scarfs down feasts of food in fractions of a second to feed his ferocious appetite. The super metabolism isn't entirely an inconvenience -- he was once poisoned by Poison Ivy and managed to run the toxins out of his system before they ever hit his heart. His grocery bill might be sky high, but it's better than a hospital bill.

RELATED:Justice League Anatomy: The 5 Weirdest Things About Deathstrokes Body

Ordinarily the Flash does not visit the hospital much in the first place, as his body actually heals far faster than a normal human as well. Generally his white blood cells and regeneration go to work immediately following any injury, allowing him to recover from near-fatal wounds in almost no time at all. Bart Allen even had his kneecap blown off and was in well enough shapeto run himself out of the emergency room shortly after.

There can be a downside to this, however, as the healing process can happen so fast that bones will grow back improperly. He's even had to break a bone all over again just to reset it, which is a major inconvenience in the midst of battle. Still, it's certainly better than the alternative and the Flash certainly isn't going to give up a handy healing factor just because it causes some unpleasantness every so often.

Keep Reading:Justice League Anatomy: The 5 Weirdest Things About Superman's Body

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Justice League Anatomy: The 5 Weirdest Things About The Flash's Body - CBR - Comic Book Resources

Grey’s Anatomy Boss Facing Creative ‘Conundrum’ With Mer-Centric Triangle – Yahoo Entertainment

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Greys Anatomy showrunner Krista Vernoff is torn between Merediths two lovers.

Ahead of the ABC medical dramas likely delayed 17th season, Vernoff tells TVLine that when it comes to Merediths latest romantic predicament does Ellen Pompeos MD get back with sorta ex-love DeLuca or pursue a relationship with new doc on the block Cormac McWidow Hayes the EP has backed herself into the best kind of corner.

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Im at the point with that story where I dont know who I am rooting for, Vernoff confesses to TVLine. I dont know if I think that DeLuca is rising to a level of dark and twisty and life experience that makes him somehow a [suitably] mature partner for Meredith. Or if all that Hayes has been through in his life already makes him her equal. I am delighted to have such a conundrum.

Vernoff credits DeLucaand Hayesrespective portrayers, Giacomo Gianniotti andRichard Flood, for bringing so much complexity to the love triangle. I thought that both Giacomo and Richard rose so beautifully to the occasion of the storytelling, she enthuses. You write a script and you think its one thing and then you see it shot and put it together and it becomes something entirely different I honestly dont know how it will end.

Greys Anatomys 16th season came to a premature conclusion earlier this month as a result of the coronavirus pandemic. As we previously reported, the original finalewas slated to revolve around a cataclysmic event that would have likely claimed the life of a major character.Greys fans may be able to glean clues about the ill-fated finale in this seasons final episodes of sister series Station 19.

Ironically, when fans watch Episode 15 and 16 of Station 19, they will probably have a feeling of some of what we had planned for [the original Greys finale], Vernoff previously told TVLine.

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Grey's Anatomy Boss Facing Creative 'Conundrum' With Mer-Centric Triangle - Yahoo Entertainment