Blood test could predict diabetes years before it strikes – Science Codex

Scientists have identified metabolites in the blood that accurately predict whether a woman will develop type 2 diabetes after experiencing a transient form of illness during pregnancy. This discovery could lead to a test that would help doctors identify patients at greatest risk and help them potentially avert the disease through interventions including diet and exercise.

The research was led by Michael Wheeler, a professor of physiology at U of T's Faculty of Medicine, in collaboration with Hannes Rst, an assistant professor of molecular genetics and computer science at the Donnelly Centre for Cellular and Biomolecular Research, Feihan Dai, a research scientist of physiology and Erica Gunderson, a research scientist at the Kaiser Permanente Division of Research in Northern California. Mi Lai, a post-doctoral fellow in Wheeler's group performed much of the analyses.

"There is a metabolic dysregulation that occurs in the group of women that will go on to develop type 2 diabetes that is present in the early postpartum period, suggesting that there is an underlying problem that exists already and we can detect it," says Wheeler, who is also a senior scientist at Toronto General Hospital Institute at University Health Network.

The identified metabolic signature can predict with over 85 per cent accuracy if a woman will develop type 2 diabetes (T2D), as described in a study published in the journal Plos Medicine.

About one in 10 women will develop gestational diabetes (GD) during pregnancy which puts them at higher risk of T2D, with 30 to 50 per cent of these women developing the disease within 10 years after delivery. The disease hampers the body's ability to regulate blood sugar levels and can lead to serious complications including vision loss, neurological problems, as well as heart and kidney disease.

Women with GD are recommended to have an annual oral glucose tolerance test after delivery, which measures the body's ability to remove sugar from the bloodstream. But the procedure is time and labor consuming and fewer than half of the women follow through with it.

"If you've got a newborn at home one of the last things you are thinking about or have time for is your own health," says Wheeler. "This is one of the main reasons why we performed this study, to potentially develop a simple blood test reducing the number of hospital visits."

Wheeler and Gunderson first uncovered metabolic signatures predictive of T2D in their 2016 pilot study of 1033 women with GD Gunderson recruited for the Study of Women, Infant Feeding and Type 2 Diabetes After GDM Pregnancy (SWIFT), one of the largest and most diverse studies of its kind. All of the women delivered their babies at Kaiser Permanente Northern California hospitals between 2008 and 2011.

The new study builds on prior research, following the same cohort of women over a longer time period during which more women developed T2D.

Baseline blood samples were collected between six and nine weeks after birth and then twice over two years. The women's health was followed through their electronic medical records for up to 8 years. During this time, 173 women developed T2D and their blood samples were compared to 485 women enrolled in the study, matched for weight, age, race and ethnicity, who had not developed the disease.

"This study is unique as we are not simply comparing healthy people to people with advanced disease," says Rst, who holds Canada Research Chair in Mass Spectrometry-based Personalized Medicine and led the statistical data analysis. "Instead, we are comparing women who are clinically the same--they all had GD but are back to being non-diabetic post-partum.

"This is the holy grail of personalized medicine to find molecular differences in seemingly healthy people and predict which ones will develop a disease," says Rst.

Rst said that, unsurprisingly, sugar molecules feature prominently among the identified compounds. But amino-acids and lipid molecules are also present, indicating underlying issues in protein and fat metabolism, respectively. In fact, the predictive power of the test dropped if amino-acids and lipids were excluded, suggesting that processes beyond sugar metabolism may occur very early in the development of the disease. The finding may help explain why complications occur in T2D patients even when blood sugar is tightly controlled with medications.

The researchers hope to turn their discovery into a simple blood test that women could take soon after delivery, perhaps during an early visit to the doctor with their baby.

The women from the SWIFT study are being invited back for a 10-year follow-up visit, where they will be tested for T2D. "The information we glean from this study will bring us even closer to our goal of developing this blood test," says Gunderson.

"It will also help us to identify metabolic differences among race and ethnic groups that this test will need to take into account. The test is intended to help obstetricians and primary care providers identify the women with recent gestational diabetes who are most at risk for developing type 2 diabetes and to support them with breastfeeding and other healthful lifestyle habits during the first year postpartum that may reduce their risk."

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Blood test could predict diabetes years before it strikes - Science Codex

Researchers Identify a Potential ‘Thinness’ Gene That Stops Mice Putting on Weight – ScienceAlert

Although scientists don't fully understand it yet, and it varies from person to person, there is a link between genetics and obesity as you've probably figured out if you've got friends who can eat whatever they like while remaining thin.

Now new research has identified one gene that could play a role. It's called ALK (Anaplastic Lymphoma Kinase), and mutations in this gene have previously been linked to certain cancers, and identified as drivers of tumour growth.

The latest study found two particular ALK variations showing up in thin, low BMI individuals - but not in individuals of normal weight. The analysis looked at the DNA of 47,102 people aged 20 to 44 years old, taken from Estonia's 'biobank', a biological database collected from a large percentage of the Estonian population.

"We wanted to understand why," says medical geneticist Josef Penninger, from the University of British Columbia in Canada. "Most researchers study obesity and the genetics of obesity. We just turned it around and studied thinness, thereby starting a new field of research."

In follow-uptests on mice and Drosophila fruitflies, animalsthat had the ALKgene turned off stayed thinner than normal even when the mice were fed what the researchers described to CNN as "a McDonald's diet".

Further tests showed that the mice without the ALK gene had lower than normal body weight and levels of body fat.

Of course correlation isn't causation. But the researchers suggest that the gene, which is highly expressed in the brain, plays a role in telling bodies how much fat to burn and how to use its energy stores.

Still, for now all we've shown is that this direct link exists in fruit flies and mice, not humans. Despite extensive research into the gene's involvement in cancer, our understanding of the ALK gene's role in human physiology remains largely unclear.

But one promising aspect of the discovery is that scientists already know how to inhibit ALK in humans because of its role in cancer development, so testing the link further is doable.

"If you think about it, it's realistic that we could shut down ALK and reduce ALK function to see if we did stay skinny," says Penninger.

"ALK inhibitors are used in cancer treatments already. It's targetable. We could possibly inhibit ALK, and we actually will try to do this in the future."

Further studies are also going to need to take a closer look at how the ALK gene operates in the brain: how it potentially balances metabolism and leads to a skinnier body shape at a molecular level.

Even if a clear link between ALK mutations and a resistance to weight gain is established, it's probably going to only be part of a much larger mix of genetic factors as previous research has hinted at.

While the biobank data and tests on mice and flies are a good starting point at solving the mystery link between genetics and thinness, scientists are going to need a lot more data in the future before we can figure out what's really happening here.

"You learn a lot from biobanks," says Penninger. "But, like everything, it's not the ultimate answer to life, but they're the starting points and very good points for confirmation, very important links and associations to human health."

The research has been published in Cell.

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Researchers Identify a Potential 'Thinness' Gene That Stops Mice Putting on Weight - ScienceAlert

Ocean ‘breathability’ key to past, future habitat of West Coast marine species – National Science Foundation

Southern part of northern anchovy's range could be uninhabitable by 2100

Anchovies are small fish that form a major part of the diet of many marine animals.

May 22, 2020

Marine species off the west coast of North America from Mexico through Canada inhabit the California Current. The cool, nutrient-rich water supports marine life ranging from invisible phytoplankton to economically important salmon and rockfish.

A new study led by University of Washington researchers finds that these species' ability to breathe may be key to where and when they thrive.

The study, published in Science Advances, uses a recent understanding of water breathability and historical data to explain northern anchovy population cycles over periods of time. The results for this important fish could apply to other species in the California Current.

"If you're worried about marine life off the west coast of North America, you're worried about anchovies and other forage fish," said lead author Evan Howard. "Ultimately it's what underpins the food web."

The National Science Foundation-funded study shows that species respond to how breathable the water is -- a combination of the oxygen levels in the water and the species' oxygen needs. Anchovy historical data match this pattern and suggest that the southern part of the anchovy's range could be uninhabitable by 2100.

"Climate change isn't just warming the oceans, its causing oxygen to decrease, which could force fish and other ocean animals to move away from their normal range to find higher-oxygen waters," Howard said.

Anchovy populations are known to cycle through time, but the reasons have been mysterious. Explanations that focused on food supplies, predator-prey interactions, competition with other species, and temperature preferences failed to fully explain the anchovy population cycles from the 1950s to today, which have been carefully recorded.

"This study demonstrates on a timescale of decades that a species is responding in close alignment with this metabolic index -- how breathable the ocean in its habitat has become," said senior author Curtis Deutsch. "It adds a new, independent line of verification that species in the ocean are arranged in accordance with how breathable their habitats are."

Added Mete Uz, a program director in NSF's Division of Ocean Sciences, "These results highlight the value of transcending disciplinary boundaries and approaching facets of a problem such as ocean circulation, physiology and ecology as interacting elements of a unified Earth system."

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Ocean 'breathability' key to past, future habitat of West Coast marine species - National Science Foundation

St. Johns Prep hand-delivering nearly 300 Class of 2020 diplomas – Wicked Local

In recognition of the unprecedented challenges this years graduating class has experienced, as well as those students unique capacity to meet the moment, St. Johns Prep is hand-delivering diplomas to its graduating seniors this month.

The journey, spanning 15 days from May 14-29, will cover 1,044.5 miles, endure approximately 200 hours and traverse 64 cities and towns across two states.

Co-piloting a school shuttle bus, Headmaster Edward Hardiman and Principal/Associate Head of School Keith Crowley are driving themselves to student residences using route-optimization software. All safe practices for Massachusetts residents issued by the Massachusetts Department of Public Health are being followed throughout the effort.

Like parents and educators everywhere, our school community has been determined to celebrate and honor our 2020 graduates by every available means, said Hardiman, a Danvers resident. From the moment this idea came up, we believed committing the time and resources to make it happen should be a top priority.

To make the initiative even more meaningful, 112 faculty and staff members have volunteered to personally attend individual diploma drop-offs for every single graduate. The vast majority of faculty and staff are making multiple home visits.

In all, Prep faculty and staff will combine to make more than 500 visits to individual diploma deliveries. At least a half-dozen faculty or staff across different departments signed up to attend more than a dozen such individual ceremonies, and several will attend more than 20.

Families have welcomed the Preps traveling commencement ceremony to front yards, side yards, back yards, curbsides, doorsteps, sidewalks and driveways all across the North Shore and beyond. The trip will carry diplomas to 14 graduates from New Hampshire, reaching as far north as New Castle and as far west as Windham. Across the Commonwealth, the route will hit municipalities along every compass point, including as far as Amesbury to the north, Gloucester to the east, Lynn and Revere to the south and Westford to the west.

Something magical happens when someone actually hands you that document, said Matt Green, a Beverly resident who received his diploma on May 19 and will attend Fordham University to study the fine arts with a concentration in theater. They made it such a beautiful moment. It was so special to have my family and teachers there to applaud. I was overwhelmed. It was an incredible seven minutes and something Ill never forget.

At a time when so many of us feel disconnected and out of sync, we believe that going door-to-door delivers a clear message to our graduates: We salute you, we celebrate with you, and were here for you, now and always, said Crowley, who also owns a degree in physical therapy and teaches human anatomy and physiology at the school. A primary focus at St. Johns Prep is guiding our students toward becoming their best selves. We hope our commitment to celebrate these graduates is a suitable model for that mission.

The Prep recently informed the families of 2020 graduates that the school is planning to host a downsized, ticketed and socially distanced commencement ceremony on campus in August, provided that the states phased reopening proceeds according to plan.

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St. Johns Prep hand-delivering nearly 300 Class of 2020 diplomas - Wicked Local

A True Miracle: This Woman Just Gave Birth To A Nintendo Switch – The Onion

Prepare yourselves for some astonishing news, gamers! A biological phenomenon previously dismissed as impossible has finally occurred, transforming our fundamental understanding of science and human physiology for generations to come. Early this Friday morning, 28-year-old Sarah Holder was blessed by miraculously giving birth to an operational Nintendo Switch!

Readers, look upon this glorious birth and be filled with wonder! This is game-changing stuff.

Heres why: For all of recorded history, our understanding of human reproductive systems has been hampered by the foolhardy belief that our physiology and video game hardware are incapable of mingling. Now, however, this single unprecedented birth has upended such unfounded beliefs, bringing us a 0.66-pound bundle of joy that includes a set of Joy-Con controllers and an adorable built-in LCD display.

Of course, every pregnancy comes with its set of challenges, and the story of this newborn Nintendo Switch is no exception. Early ultrasounds revealed that the developing console started out sharing the womb with a human twin before absorbing the childs nutrients in order to develop a functional touchscreen. Doctors also had to untangle the Switchs power cords, which had become dangerously wrapped around its screen during birth, threatening some of the consoles crucial operating capabilities.

Despite these difficulties, however, Holder described the console in an interview with OGN as the best thing that had ever happened to her. Watching the new mother swaddle her newly delivered console while staring into its glowing screen really hit home for us how this isnt just a win for gamers everywhere, its also a feel-good story with a genuinely happy ending.

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A True Miracle: This Woman Just Gave Birth To A Nintendo Switch - The Onion

Alternative Treatment for Mesothelioma in Herb-like Compound – Surviving Mesothelioma

A man-made version of a traditional Chinese herb could be an alternative treatment for mesothelioma.

Turkish researchers have published a new study on a drug called halofuginone. The study shows the drug has significant anticancer effects on mesothelioma cells.

In an article in Cell Biology International, they explore how halofuginone affects mesothelioma and lung cancer cells.

Mesothelioma is an asbestos-linked cancer that is hard to treat. Pleural mesothelioma is the most common type. Pleural mesothelioma grows quickly. It usually causes few symptoms until it is very advanced.

Chemotherapy is the main treatment. When that stops working, many patients look for an alternative treatment for mesothelioma.

Scientists are studying immunotherapy, new kinds of radiotherapy, and even light-based treatments for mesothelioma. So far, there is no reliable second-line alternative treatment for mesothelioma.

Halofuginone is a synthetic molecule. It is an analog of febrifugine. Febrifugine is an alkaloid found in the Chinese herb Dichroa febrifuga (Chang Shan).

In 2015 , Israeli researchers published an article about halofuginone. They wrote, During recent years, halofuginone has attracted much attention because of its wide range of beneficial biological activities, which encompass malaria, cancer, and fibrosis-related and autoimmune diseases.

The Turkish study aimed to understand halofuginones effect on mesothelioma cells. If it limits their growth or causes cell death, it could be an alternative treatment for mesothelioma.

This was the first time for halofuginone tests on malignant mesothelioma cells. Researchers tested the alternative treatment for mesothelioma on lung cancer cells, too.

They found that the drug interrupts the cell cycle. It interferes with signaling proteins. This causes mesothelioma cells to die earlier and at a faster rate. The more halofuginone the researchers used, the more mesothelioma cells died. This was also true for the lung cancer cells.

HF exerts its anti-cancer effects in lung-derived cancers by targeting signal transduction pathwaysto reduce cancer cell viability, induce cell cycle arrest, and apoptotic cell death, writes lead author Asuman Demiroglu-Zergeroglu.

Malignant cells were more susceptible to halofuginone than normal cells.

The research team concludes that halofuginone might be an alternative treatment for mesothelioma. But there have been no US clinical trials on Chinese herbs for mesothelioma.

A British Medical Journal published a review of Chinese clinical trials on herbs in 2013. Most of those studies combined conventional and alternative treatment for mesothelioma.

Source:

Asuman, DZ, et al, Anti-carcinogenic Effects of Halofuginone on Lung Derived Cancer Cells, May 21, 2020, Cell Biology International, Epub ahead of print, https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.11399

Qihe, X, et al, The quest for modernisation of traditional Chinese medicine, June 13, 2013, BMC Complementatry and Alternative Medicine, pp. 132, https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-13-132

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Alternative Treatment for Mesothelioma in Herb-like Compound - Surviving Mesothelioma

New research could be a breakthough in collagen and stem cell research – Truth In Aging

New research has identified two actives that can prevent stem cell decline as we age and increase collagen 17 levels in cells. It was published in Nature last year and has just been covered in Scientific American. The study was described as elegant by a prominent dermatologist, not involved in the project. As I am always on the look out for next big thing in antiaging skincare, I pounced.

Ill cut straight to the car chase. The two actives are Y27632 and apocynin and I was curious to see if they could be tracked down outside of a lab and, perhaps, in our potions and lotions. The first is a chemical that I havent been able to track down. Happily, I had better luck with apocynin.

Apocynin has been identified in a specific strain of cannabis, but also in cloudberry. And rubus chamaemorus (AKA cloudberry) seed oil is in a facial oil by Keracell. Ill post a link at the end of this article.

So, how do Y27632 and apocynin work? Emi Nishimura, a professor of stem cell biology at Tokyo Medical and Dental University in Japan, revealed that aging and UV exposure deplete stem cells of a crucial collagen protein. Heres what happens.

As part of normal skin health, the top layer of the epidermis is constantly being sloughed off and replaced from a self-replenishing pool of stem cells in the basal layer. These stem cells have roots that anchor them to a thin piece of tissue called the basement membrane that connects the epidermis and the dermis. Only when tethered can they replicate and mature into another type of cell.

This is where collagen 17 comes in. This collagen protein does the tethering (see the "adhesive molecule" in the illustration above), rooting the stem cell to the basement membrane. As stem cells become damaged, they lose precious amounts of collagen 17. The more protein they lose, the weaker their bond to the basement membrane, until eventually they are forced out by neighboring healthy cells.

Thats why this study is potentially a breakthrough. It has identified the process, the key protein that needs to be replenished and the chemicals that might just be able to do that.

You can find rubus chamaemorus (AKA cloudberry) seed oil and a potential source of apocynin in KERACELL Liquid Gold Enriching Elixir ($160 in the shop).

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New research could be a breakthough in collagen and stem cell research - Truth In Aging

On the Basis of Gender – The Viking Magazine

Left foot forward. Right foot forward. While that may well be the mantra playing in 18-year-old Caster Semenyas head as she flies furiously down the length of the track towards the finish line, the spectators watching her would be lucky to be able to distinguish between her feet as she runs. Her high speed reduces her muscular figure clad in a South-African-colored uniform to a blur of green and yellow as she finishes almost a full second before her closest opponent at the World Championships in the 800 meter race.

Semenya didnt just win her event she dominated it.

But later that fateful night in 2009, instead of being celebrated for the young phenom that she had trained arduously to become, Semenya came under fire for potentially having an unfair advantage as the public began to question her biological sex. The intrusive testing and inquisitions that followed affected Semenyas ability to compete, but she did her best to hold her head high and carry on as people picked apart her prowess. Semenyas case was just one of many that deals with the complicated role of gender in sports, a topic that becomes increasingly relevant as athletic science improves and athletes of all genders become faster and stronger than ever before.

When people think of sports, their mind often divides mens sports and womens sports into two separate entities, with the athletes within them as strictly binary. Sports have been categorized this way throughout history with the intention of ensuring that competition that ensues will be fair. But how do we define fair, and will this rigid separation continue to be the norm in the future?

In some sports, such as distance swimming, the average percent difference between men and womens times is a slim 5.5%, according to a 2010 study in The Journal of Sports Science and Medicine. In other sports, such as weightlifting, this difference is more significant at 36.8% according to the same source. Because each sport is unique in the physical challenge it presents to athletes, the same standards for legislation and rules regarding gender and fairness cannot be applied universally.

Recently, there has been an increase in discussion surrounding transgender athletes competing in the gender category that best matches their gender identity. While some push back against trans inclusion in situations such as the Idaho bill passed in March that enforces genital and hormonal testing of athletes, others fight for equality in sport. Harvard graduate Schuyler Bailar a trans swimmer who was accepted onto the mens team and found great success and joy in living life as his most authentic self is one of the athletes leading the fight for gender inclusivity in sports. The role that gender plays in sports is already complexthe way gender and sports will interact in the future is even more so.

Despite a social movement towards increased transgender inclusion and a general heightened understanding of what it means to be transgender, many major sports leagues, such as USA Powerlifting, have chosen to keep their original policies in place. In a statement of the organizations transgender participation policy, the USA Powerlifting league cited both the physical advantage of males and a ban on the androgens often used to transition from female to male as reasons for their stance.

While the term discrimination is used to catch the attention of the public, it is most often misused, the statement read. We are a sports organization with rules and policies. They apply to everyone to provide a level playing field.

While some question whether the USA Powerlifting policies are discriminatory against transgender athletes, the organization said it is fair in a sport largely based on physical strength and compared gender discrimination to policies surrounding age restrictions.

This bill attempts to solve a problem that does not exist while slamming the door shut for transgender student athletes to fully participate in their school communities.

Kathy Griesmeyer

At the high school level, some athletes have protested transgender participation in the gender category of their choice. Recently, at a high school in Connecticut, the families of female track runners filed a lawsuit against the participation of transgender athletes in womens sports, arguing that their female children competing against runners with male anatomy could hinder their personal chances of earning track titles and scholarships.

Those who share the same opinion as those parents have formed conservative groups and are supported by legislators throughout the states that are looking to ban participation of transgender athletes in both mens and womens sports. For example, the Idaho state Senate recently passed Republican-sponsored bill 24-11. If signed, this bill would prohibit both trans and intersex girls from competing in the girls heats of high school and college sports.

If a female athletes sex is questioned by a coach, parent, or administration of the other team, the future of that athletes participation depends on if their biological sex is confirmed by a signed physicians statement that shall indicate the students sex based solely on: The students internal and external reproductive anatomy; the students normal endogenously produced levels of testosterone; an analysis of the studentsgenetic makeup, according to the bill.

This bill fails to acknowledge that the inclusion and acceptance of transgender people and their identity is extremely important to their well being, both physically and mentally. By reducing someone to their biological sex characteristics, one is blatantly disregarding their internal identity.

Additionally, this bill only targets female athletes, requiring them to go the extra step if their sex status is questioned in order to play their sport, while their male counterparts do not have to endure this same burden. This suggests that, should a woman have success in an athletic event, her success may be attributed to genetic alterations rather than talent.

Kathy Griesmyer, a policy director with the American Civil Liberties Union of Idaho, is disappointed with this bill, citing that it is intentionally transphobic and that it makes things more difficult for athletes that already face many social hurdles simply for fulfilling their true sense of identity.

This bill attempts to solve a problem that does not exist while slamming the door shut for transgender student athletes to fully participate in their school communities, Griesmyer said in a statement in response to the bill. Idaho has not seen any issues with trans girls competing in the girls sports. This unconstitutional and mean-spirited bill prevents trans girls from finding community and self-esteem in sports, and will certainly result in litigation to defend the civil rights of Idahos transgender community.

In addition to being transphobic, this bill is an invasion of the athletes privacy and puts power in the hands of coaches or parents who may use it to place their competitors at a harsh disadvantage.

In a similar proposition, legislation announced in January could prevent transgender women in Arizona from participating in athletics teams based on their gender identity, requiring some females athletes to provide a doctors note stating their biological sex in order for them to compete in their sport.

However, this rule only applies to womens sport and not to male counterpart sports. The vast majority of the arguments surrounding barring transitioned athletes center solely on male-to-female athletes. Those critics cite the biological differences between men and women that, they claim, could lead to significant competitive advantages for male athletes. Most of these changes take place during puberty: a biological male undergoing puberty will see a host of changes due to their significantly elevated testosterone levels compared with biological females. According to a study comparing female to male testosterone, an adult male will have seven to eight times the natural testosterone coursing through a womans body on average.

This testosterone is accompanied by scores of physiological changes, among them larger muscles, denser bones and a higher proportion of lean body massits these traits that lead to the bigger, faster, stronger notion surrounding male athletes.

While transitioning to female often involves the use of testosterone suppressants and estrogen, most in favor of barring trans athletes argue that these measures dont reverse the increased bone density, superior musculature, and other characteristics of male puberty.

So despite the fact that female-to-male athletes who choose to undergo hormone therapy treatment will also have elevated testosterone levels, this isnt seen as a threat: the vast majority of benefits will be derived from a biological male puberty, not from an addition of testosterone to a body thats undergone female puberty.

But, of course, thats not always the case. A 2016 Washington Post article examining the trans advantage cites that after a year of hormone therapy, female trans distance runners completely lose their speed advantage over cisgender women. Similarly, individuals like Nancy Barto, an Arizona state representative, recognize that regardless of whether a male-to-female athlete will have a greater advantage in sports than a female-to-male athlete, legislature that targets women specifically cis or otherwise puts up barriers to prevent their participation. This type of legislature in sport is counterproductive, introducing yet another in a long line of historical roadblocks for female athletes.

When this is allowed, it discourages female participation in athletics and, worse, it can result in women and girls being denied crucial educational and financial opportunities, Barto said in an interview with NBC News.

The recent passage of such legislation such as the bill signed by Idahos governor on March 30 raises questions about what, exactly, constitutes someone as being transgender. Legislators such as Representative Barbara Ehardt, a sponsor of the bill passed in Idaho, have said that genital exams and genetic and hormone testing could easily determine an athletes sex. However, in reality, sex testing may not be that simple, as it is difficult to come up with metrics to objectively distinguish between different sexes.

Some of the sex testing methods that Ehardt cited may even produce contradictory results. At the 1966 European Track and Field Championships in Budapest, Polish sprinter Ewa Kobukowska passed a genital exam and qualified as female. The following year, Kobukowska failed a chromosomal test, and was barred from participating in the European Cup womens track and field competition in Kiev. An analysis later found that she had a set of XXY chromosomes.

A similar issue arises when it comes to hormone testing. The International Association of Athletics Federation, which sets testosterone limits for women in racing events ranging from the 400-meter to one-mile race, bans athletes who produce abnormally-high levels of testosterone from participating in womens sports.

In 2011, the IAAF set the limit for womens testosterone levels at 10 nanomoles per liter of blood, widely considered the lower end of the typical testosterone level among males. This limit barred Dutee Chand, an Indian sprinter who naturally produces high levels of testosterone, from competition. Chand later won an appeal against her ban; the court agreed with Chand that there was no scientific evidence linking high testosterone levels to better athletic performance. The IAAF commissioned a study in 2017 and justified with data that was highly scrutinized lowered the limit to five nanomoles per liter seven years later, a change that was meant to ensure a level playing field for athletes, IAAF President Sebastian Coe said. Critics argued that the data was flawed, and urged the IAAF to retract the study, which was published in the British Journal of Sports Medicine.

However, the IAAF stood firmly behind its study and said it would not retract the paper. Our evidence and data show that testosterone, either naturally produced or artificially inserted into the body, provides significant performance advantages in female athletes, Coe said. The press release goes on to state that most females have testosterone levels of between 0.12 to 1.79 nanomoles per liter, and that no females testosterone level would exceed the IAAFs new limit unless they had disorders of sex development or a tumor.

An example of a female athlete with higher than usual levels of testosterone is track champion Caster Semenya of South Africa. She began running seriously at age 12, and by the time she became an adult, she was competing in the Olympics. Due to her incredible success and ability, suspicion arose regarding Semenyas biological sex and levels of testosterone. She soon found herself the target of an extremely intrusive media investigation and was eventually barred from competing; after an investigation discovered that she was born with XY chromosomes, Semenyas genetic makeup was ruled an unfair advantage over her competition.

On August 19, 2009, Semenya won the 800-meter event in the World Championship by a landslide, but following this impressive feat came a seemingly never ending public investigation into her biological sex and sex characteristics.

Along with stripping Semenya of any type of celebration or praise for her accomplishments, the public reduced her feats to her gender. The scrutiny Semenya endured is disproportionate to her situation, as she is seconds off the world record and is relatively competitive with other female athletes, disproving the idea that she has an unfair advantage she is simply talented at what she does.

Typically, it is women who endure accusations of this nature. Michael Phelpss abnormally long wingspan is never labeled as an unfair advantage; it is simply a tool that makes him successful. Most professional basketball players are extremely tall compared to the general population, making them genetic oddities, and this is never labeled as an unfair advantage. Yao Ming, for instance, is a staggering 76 tall, a height thats inspired countless conspiracy theories about whether the star was bred in a lab rather than born to his 63 mother and 67 father. Tinfoil hats aside, Mings height enabled him to tower over even his fellow NBA competitors. Ming is nearly a full foot taller than the average NBA player, who stands at 67, and nearly two feet taller than the average American male, who stands at 59, which gives him a clear competitive advantage based on his genetics. And instead of protesting Usain Bolt, society hails him as the fastest man in the world, despite his body being described as built for speed due to his abnormal proportions. In a BBC News article, former Great Britain sprinter Craig Pickering said, Bolt is a genetic freak because being 65 tall means he shouldnt be able to do what he does at the speed he does given the length of his legs.

Along with stripping Semenya of any type of celebration or praise for her accomplishments, the public reduced her to her gender.

The main goal of most professional athletes is to be the best they can, so why was Semenya punished for her gift? The examples listed above are few compared to the gifted male athletes celebrated for the genetic gifts that enable them to compete leaps and bounds ahead of most athletes. And the countless examples seem to point to one central notion: men who are good at what they do are not held to the same unreasonable standards or stigma as their female counterparts.

Although Semenyas case has gained notoriety, she is not the first female athlete to face restrictions from her sport when her performances were deemed, essentially, too good to be true. Maria Jos Martnez-Patio, an internationally-recognized hurdler turned college professor, has a history that eerily parallels that of Semenya, so much so that Martnez-Patio calls herself the Semenya of the 1980s, according to a profile with the United Kingdoms Times. Martnez-Patio faced little scrutiny or public attention initially; at 22, she was given a certificate of femininity after passing a sex test the title is often awarded after enduring humiliating and intrusive tests such as gynecological exams, MRIs, and ultrasounds enabling her to advance to the quarter finals of the 100-meter hurdles at the world championships in Helsinki.

But in 1985, her troubles began.

At the World University Games, a new test karyotype analysis that examined her chromosomes directly found that she had an XY 46th chromosome, the chromosomal pattern typical of a biological male. Martnez-Patios story was more complex than her chromosomes she has androgen insensitivity syndrome which means her body doesnt respond to testosterone in a typical fashion, so any advantage she was perceived to have was likely naturally negated but the storm of public backlash that poured down on her was indifferent to that fact. After her test, Martnez-Patio was ruled ineligible to participate in femaleathletics, and even encouraged to fake an injury to leave quietly. She suddenly found herself barred from the sport shed played and loved all her life and newly privy to information regarding her sex that would leave anyones head spinning if not reconsidering what theyd thought was the truth about their gender their entire life. If the sudden onslaught that had struck Martnez-Patio wasnt already enough, the humiliation and shame of being pushed to lie, to leave gracefully not to make a scene was the final straw. Despite her initial compliance with the injury scheme, Martnez-Patio chose to fight back. In 1986, despite the public media skewering shed endured, she entered the Spanish national championships 60-meter hurdles event. She was told she had two options: withdraw from the event discreetly, or face public condemnation. She chose the latter. After competing and winning, she was stripped of her scholarship and athletic residency, and faced consequences in her private life that were far more hurtful than any Spanish press article.

In The Times article, Martnez-Patio describes how she suffered after the test. I lost my boyfriend because all the media said I was a man, Martnez-Patio said. On many occasions, I thought the best thing was to die because I could not stand so much suffering and injustice. I had to leave my residence in a high-performance center in Madrid within 24 hours. I was on the street. The most complicated thing is having to publicly demonstrate your status as a woman before the whole world. You feel as if everyone is talking about the amount of woman that you are. And this stigma accompanies you for the rest of your life.

Similarly to Martnez-Patios situation, when she was told to cease competing until her chromosomal test results were returned, the International Amateur Athletic Federation, or IAAF, requested Semenya to refrain from competing until there was a definitive conclusion from sex verification tests. As this all occurred, Semenya, her family and her team upheld the statement that she was biologically female and had identified as a woman since birth, regardless of her abnormal hormone levels.

However, this type of testing is not as accurate or conclusive as many hoped it would be. According to many studies and Dr. Gerald Conway, an endocrinologist who worked on the study of Semenyas hormones, while it is true that higher-than-usual levels of testosterone can give an individual an advantage in sport, this is not always the case.

There is an advantage to exposure to testosterone, which is why people use testosterone as an anabolic steroid, Conway said. There are natural conditions, where women normally have more testosterone in circulation, and they would have a biological advantage in many sports arenas.

But the quantitative level of testosterone in ones blood isnt the end all be all, as some women do not react to having high levels of the hormone because their bodies simply dont recognize it.

Katrina Karkazis, a cultural anthropologist and research fellow at Yale, co-authored the book Testosterone: An Unauthorised Biography with Rebecca Jordan-Young, a sociomedical scientist. In it, Karkazis and Jordan-Young critique and dismantle the previously believed effects testosterone has on the body.

In an interview with The Guardian, Karkazis discussed misconceptions about the actual impact testosterone can have on an athlete.

Testosterone is a very dynamic hormone, Karkazis said. Its actually responsive to social cues and situations. For example, if a coach gives you positive feedback, that can raise your testosterone level Where we run into trouble is trying to make comparisons across individuals based on testosterone levels. Sometimes its individuals with lower testosterone who do better. So its not as simple as saying more testosterone equals better performance.

Schuyler Bailar made history as the first openly transgender swimmer in the NCAA. As a member of the graduating class of 2019 from Harvard, the Virginia native took a gap year after high school during which he came out as transgender. After becoming a star swimmer in high school, Bailar had been recruited to swim for the womens team at Harvard, although after coming out he was unsure if he would be able to swim on the mens team once his education at Harvard began.

In an interview on the Ellen Show, Bailar said that while he has not been as competitive in mens heats in comparison to the dominance he showed when racing against women, he doesnt mind. Bailar admits that while he is no longer placing first, he is holding his own in races, defying people who support barring trans athletes from existing as themselves.

Im not winning anything, but I think Im not awful, Bailar said with a smile on his face. I keep up with my teammates and I keep up with the people around me, but Im not winning anything like I used to and thats definitely humbling.

While some people may argue that trans athletes fight to change which gender category they compete in for an advantage or other external reasons, Bailar is simply living life in a way that feels true to himself and because the sport is important to him. Along with being a swimmer, Bailar has become a public speaker, and aims to raise awareness about transgender youth in sports.

It [not winning] has helped me develop something I was working on before, which was learning to love swimming just for swimming, and I think that theres a lot of other kinds of glory in that, Bailar said.

I was just ecstatic and it was as much glory as I wouldve gotten in first place. Probably more, because I was myself.

Schuyler Bailar

Bailar has found that having the support of his team and improving on his own personal times can be just as exciting and rewarding as a medal.

In my last meet, I got sixteenth place, which obviously is not first place, Bailar said with a laugh. But the whole team was on the side of the deck and they jumped up and were screaming for me because I dropped a lot of time from my best, so I did really well relative to myself, and I was just ecstatic and it was as much glory as I wouldve gotten in first place. Probably more, because I was myself.

Elizabeth Edwards, an 18-year-old senior at the Urban School of San Francisco and a transgender woman, believes legislation which requires sex testing doesnt work and unfairly discriminates against transgender women like herself.

The requirement of gender reassignment surgery is ridiculous, especially considering the absurdly strict medical standards currently held in the US to qualify trans people to undergo them, Edwards said. Also, sex verification standards leads without fail to unfair standards of gender expression normativity that bear down on cis people, and result in cis people being disqualified on bases of uniquely high/low chemical levels that result from normal variance in such factors across the cisgender population.

A study conducted by researchers from the Department of Molecular and Cell Biology and Biochemistry at Brown University found that as many as 2% of the population have traits which deviate from the ideal male or female, including hormone levels and the structure of the internal genital duct systems and external genitalia. This seems to suggest that sex testing would not necessarily be as straightforward as critics suggest.

According to Edwards, at the professional level, the highest reasonable requirement should be proof that an athlete has undergone hormone reduction therapy for 18 months.

By that point, trans and cis people are chemically identical, and such quote-unquote biological dis/advantages such as bone density will have fallen to the wayside, Edwards said.

While research on this subject has hardly reached a consensus, a meta-analysis of eight research articles conducted by researchers from the Nottingham Centre for Gender Dysphoria and Loughborough University concluded that there is no evidence that hormones such as testosterone give transgender female athletes an advantage.

The analysis also reviewed 31 sport policies from various national and international competitions and found that rules restricting participation from transgender athletes discourage transgender athletes from participating in sports.

Within competitive sport, the athletic advantage transgender athletes are perceived to have appears to have been overinterpreted by many sport organisations around the world, which has had a negative effect on the experiences of this population, the analysis reads.

The researchers also write that sports organizations need to improve their policies to be more inclusive.

Given the established mental and physical health benefits of engaging in physical activity and sport, the barriers transgender people experience are a significant limitation to the promotion of healthy behaviours in transgender individuals, the analysis reads.

Kay Svenson, a Paly alum and recent graduate of Wellesley college, is a trans activist and believes that trans people, like all people, have the right to be treated in accordance with their gender identity, and this includes sports.

Sex-based discrimination is prohibited under Title IX, and that amendment is not up to the free interpretation of the (potentially transphobic) governing bodies of the state or local school district, Svenson said. We need to work harder to ensure that differences in birth anatomy do not shape our definition of athletic fairness.

Svenson believes that it is important that transgender people have the means and support to pursue their personal athletic careers, free of judgment.

Trans athletes have just as much of a right as cis athletes do to compete in the gender category that they identify with, Svenson said.

While there is no explicitly correct answer or proposed set of regulations surrounding the role of gender identity in sports today, if athletes and fans alike continue to ask hard questions respectfully and work towards giving everyone the opportunities to enjoy sports, compete as themselves, and make sure matches remains competitive, it will be a victory for everyone. Nonetheless, as gender identity and societal views surrounding the gender spectrum become more well understood and all-encompassing, the issues described will only become more complex. Its time to have conversations about this topic now so were ready for the more complex questions later.

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On the Basis of Gender - The Viking Magazine

Biology Arrives In the Greek Words To Additional Info, Please Read This Article – NewsDay

The three wordsbiology,geologyastronomy is derived from this Greek term.

The very first thing we need to bear in mind when coping with scientific investigations may be that the meaning of the two phrases. Just what could be this significance of those words study? If people talk aboutgeology, what are they talking about? What they truly are speaking about is that the analysis of rocks or perhaps the study of fossils.

Whenever some one talks about fossils, that which they truly have been referring to is that the process of fossilization. Inorder for those rocks there has to be a certain number of oxidation, which can only come about at particular intervals of why not try here time.

For this procedure an amount of heat must be found on Earth earth. These will be the true meaning of geology. The studies of rocks and fossils are typical related to the origin of life.

The thing is archaeology. It simply meansto find the last. For archaeology to function, there has to be always a math.cas.lehigh.edu specific degree of wisdom and knowledge . The theory of development relies upon the notions of archaeology.

The true analysis of evolution needs to accomplish with its particular own shape in the modern occasions and the knowledge of living In spite of the fact that it is interesting to know the references to dinosaurs. In the event that you would really like to understand the origin of life, you have to understand that the plan of archaeology.

The third word is embryology. Its the study of the growth of living things on earth. The process is just one among the earliest & most recognized methods, although there are a number of distinctive procedures of studying embryology.

The baby was is explained by embryology. We are capable analytical thesis statement of knowing relating to embryology. We are all capable of thinking that it developed from some sort of fertilization or that an creature came to be.

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Biology Arrives In the Greek Words To Additional Info, Please Read This Article - NewsDay

The pause on parenthood! How Coronavirus is messing up baby dreams – Mid-day

Last month, the Human Fertilisation and Embryology Authority (HFEA), which regulates Britain's fertility industry, ordered private and the National Health Service (NHS) clinics to stop treating patients who are in the middle of an in-vitro fertilization (IVF) cycle. All new treatments had also been banned. Experts believed that this decision would prevent the birth of at least 20,000 babies if the policy were to stay in place for 12 months. But on May 1, the fertility regulator did a U-turn, lifting the suspension of fertility services, provided they were taking safety precautions for both doctors and patients.

The conundrum is more or less the same in Mumbai. Much before the Janata Curfew was imposed by Prime Minister Narendra Modi on March 22, a few fertility clinics in Mumbai had already shuttered. Dr Firuza Parikh, director, Assisted Reproduction and Genetics at Jaslok Hospital and Research Centre, says, "A week before the nationwide lockdown, Jaslok shut its fertility clinic for two reasons. We wanted to ensure the safety of our patients since we did not know what course the infection was going to take in Mumbai or Maharashtra. Second, we thought the government needs hospitals and healthcare workers to tend to COVID patients. We didn't want to sap resources including anaesthesia medicines, medical talent, etc., which could otherwise have been used to contain the spread of Coronavirus. We decided to pass on all the resources from our inventory to the ICU. The supply chain of PPEs had not started then, so this felt like the right thing to do."

Dr Firuza Parikh

Jaslok's fertility centre had around 40 patients who were in the middle of their IVF cycles at that point. Dr Parikh says we can no longer view the world from an individual standpoint. "It has to be about 'us'. I personally made calls to all our patients to explain the reason behind the decision. While a majority of them agreed with us, some women who had come down from the US and wanted to do multiple cycles of IVF at our centre, weren't pleased," she adds.

Dr Parikh explained the dangers. During the Zika virus outbreak, several newborns ended up being infected as their mothers were in the first trimester when they contracted the virus.

While there is no mandate from the Centre or the state government on the closure of fertility centres, it was a decision taken unanimously by most gynaecologists in the city. NOVA IVF fertility centres in Chembur and Andheri, too, shut down when the lockdown was imposed. Around 75 IVF cycles were underway at NOVA at that time. Dr Ritu Hinduja, consultant fertility specialist, NOVA, explains, "We didn't know if we were equipped to deal with patients during the pandemic. But before we closed, whatever injectable cycles were ongoing, we completed those, created embryos and cryopreserved them within a week."

Dr Ritu Hinduja

If embryos are cryopreserved, they can be transferred into the patient's womb at a suitable time. Once the eggs are frozen, the couples need not worry, Dr Hinduja adds. But what about those who had to leave the cycle in the stimulation phase? "They have to restart the IVF procedure when the world opens up. But we tried to finish ongoing cycles as we knew it would be mentally harrowing for patients. Some couples wait for years to have this procedure.

So while this is not a typical emergency service, it is indeed an emergency for some desperate couples."

Shweta and Sailesh Kumar may have to wait even longer. The Kumars have been undergoing IVF treatment under Dr Hinduja's supervision. "We have been married for four years. Last year, my wife was diagnosed with systemic lupus erythematosus (SLE), an autoimmune disease." In this condition, the immune system of the body mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain and other organs. "Our rheumatologist advised us to freeze her eggs as the treatment for SLE could have an effect on them." Just before the lockdown, Shweta's condition improved and her rheumatologist gave her a fitness certificate to go ahead with the pregnancy. "We decided to do the transfer of embryos but due to the lockdown, the procedure has been put on hold," Sailesh says.

The couple's case is unique. Since Shweta is a high risk patient, doctors advised her against venturing out for IVF treatment during the pandemic. They have staggered her transfer, because she has co-morbidity.

At both Jaslok and NOVA, doctors are ensuring that tele-consultations are available to patients to allay their fears. Dr Parikh says, "It's important for them to know when we will start OPDs again. About 50 per cent of our patients come from outside Mumbai, and about 10 per cent are from outside India. So, unless travel restrictions are lifted, we cannot help them."

Dr Prakash Trivedi

Dr Prakash Trivedi, well-known gynaecologist and president of the Indian Society For Assisted Reproduction (ISAR), facilitated a meeting of stakeholders last week to discuss the issue. "We recommended that couples who are not showing any COVID symptoms, have tested negative and are keen on IVF, could be treated. But necessary precautions need to be taken, both by doctors and patients. Since we don't know if the patient can contract the virus during IVF, we will only allow transfer of embryos. But this will be done after offering thorough counselling to the couples. We have also recommended that the embryos of patients undergoing IVF post-COVID be separated from the ones done before in different jars. This is to ensure safety of all patients," he shares.

According to him, there are close to 3,000 fertility centres across India, of which most have voluntarily decided to close temporarily. While Jaslok and NOVA are aiming to open up their OPDs for embryo transfers, they are yet to decide on whether to take on a new patient to start a fresh IVF cycle.

Ovulation Stimulation: During the stimulation phase of an IVF cycle, female patients are administered hormones for a period of 12 days.

Egg retrieval: Patient is put under mild sedation and the eggs are collected.

Sperm retrieval: Male partner is asked to produce a semen sample. The specimen is washed, and those that display maximum motility are selected.

FertiliSing the eggs: Retrieved eggs are fertilised with sperm. The eggs are regularly monitored to confirm the fertilization.

Embryo transfer into uterus: Embryologists monitor the embryos growth and viability to determine whether a transfer should be done.

After Transfer: Two weeks after retrieval, a pregnancy blood test is performed. If this test is positive, the patient is considered four weeks pregnant.

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The pause on parenthood! How Coronavirus is messing up baby dreams - Mid-day