FAMILY MATTERS: Playing to the traits we are born with – Andover Townsman

Dear Doctor,

Our two young children are as different as daylight and darkness. While they are both still young, they are not alike at all.Our son is 8 and our daughter is 6. He is thoughtful and slow to speak or act. She, on the other hand, is talkative, quick to do what she wants, and knows her mind even when its not appropriate. Do behaviors come as inherited? Both children are ours, but we wonder where their differences come from.

Curious

Dear Curious,

Children come as their own package of likely behaviors.

There was a time in behavioral and educational theory that it was believed the mind was a tabula rasa (blank slate) on which could be writ whatever a parent ordained. That theory is not widely accepted today.

Think about it. As you consider your friends and neighbors, do you not have an amazing range of gifts and variability in behavior? Isnt this what makes our species so rich and different? All human behavior is on a curve. Some have less of a trait and others more. Many are average with one trait or another.

Trait psychology is here to stay. Any parent or grandparent will tell you children come with unique and sometimes welcome or unwelcome behavioral tendencies and styles.

For example, in the same family, one may see one child who is giving and unselfish. Another may make Scrooge look generous. Why? The unique inheritance of different neurologies and consequent traits results in variability. What would the world be without variance? It would be colorless indeed.

Now comes the troublesome part. Some traits are much less desirable than others. Thus, it is important to consider a basic trait and the life experiences of any person. The difference between a great artist and a destructive force is less than we might think.

How to enhance the positive and not reinforce the less desirable is, in my opinion, the consummate skill of an effective parent. That will be the topic of another column.

Dr. Larry Larsen is an Andover psychologist. If you would like to ask a question, or respond to one, email him at lrryllrsn@CS.com.

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FAMILY MATTERS: Playing to the traits we are born with - Andover Townsman

HILLEL’S TECH CORNER: Making the eyes the windows of disease diagnostics – The Jerusalem Post

Ive covered eye-tracking technology many times over the years, which has since grown to become a saturated market that never ceases to amaze me. After all, we all grew up seeing such futuristic technology in sci-fi movies. Yet here we are life is mimicking art in a way never done before.Eye-tracking technology has been known to detect the identity/presence, attention levels and focus of the user. The information collected from the eyes grants unique insights into human behavior, and it has helped pave the way to the creation of a broad range of vitrual-reality devices and augmented-reality applications.They say the eyes are the windows into the soul, which begs the question: What else can they reveal about us?I recently discovered that eye-tracking technology offers up more than just the cool sci-fi stuff. It can also serve as the basis to address something more serious: disease diagnostics. Allow me to introduce you to AEYE Health.AEYE Health uses advanced machine learning and artificial-intelligence technologies to develop algorithms that can detect a variety of retinal conditions in seconds. This test can be performed in various places such as primary care clinics during the annual check-up, and only the patients that are diagnosed with an eye disease or have suspicious findings are referred to the ophthalmologist for treatment. The company was founded roughly two years ago by two experienced, successful entrepreneurs. It set out to diagnose diseases from retinal images, and is now approaching a crucial milestone: diagnosing images of the fundus.The fundus is the area toward the bottom of the eye that is exactly opposite the lens. Images from it can be used to detect a variety of illnesses, some of which are vision threatening, such as diabetic retinopathy, glaucoma and age-related macular degeneration (AMD). Retinal images can also be used to diagnose systemic diseases: hypertension, cardiovascular diseases, some forms of cancer and Alzheimers disease, to name a few.The diagnosis of fundus images is still primarily conducted by highly skilled and experienced humans, which makes the availability of this crucial procedure extremely limited. That leaves many patients with sight threatening conditions to suffer from entirely preventable blindness and vision impairment, or even premature death.The numbers are staggering, especially when you go beyond vision-related issues. There are an estimated billion people world-wide who are at high risk, out of which about half a billion are diagnosed with diabetes. In the US alone, about 75 million people are considered high risk and should be screened annually. THE VAST majority, however, does not get screened, in part because the procedure is impractical, expensive and because the number of professionals certified to diagnose is limited. This is where AEYE Health comes in.AEYE Healths algorithms are the only ones that can detect a variety of conditions at the highest known degrees of accuracy (specificity and sensitivity), and are designed to work with a variety of cameras, including low-cost, portable hand-held cameras. They are now in the final stages of a multi-site clinical trial required to get the FDAs clearance. The clearance will enable the deployment of their technology commercially, which will make screening patients eyes much more accessible, thus saving them from preventable blindness.AEYE Health was founded by two experienced entrepreneurs: CEO Dr. Zack Dvey-Aharon, an expert in machine-learning who has founded a number of companies in the field, and COO Danny Margalit, who was the co-founder of Aladdin Knowledge System, which went public on the NASDAQ in 1993 and was acquired in 2009.There are currently 14 people working for AEYE Health, and the majority of them are mathematicians and software engineers located in the R&D center in Tel Aviv, while the HQ is located in New York. They are backed by Boston based venture-capital funds Falcon and R-Cubed, and a number of angel investors from Israel and the US, including Club 100 from Israel. To date, the company has raised $3 million.AEYE Health is part of a growing wave of advanced technology companies that use the combined power of neural networks, artificial intelligence, and machine-learning algorithms to make medical treatment much more accessible and cost-effective than it currently is. There are some other giants battling in the same arena, notably Google and IBM. However, in true start-up fashion, AEYE Health is more advanced and widely respected for its under-a-minute noninvasive procedure.Many family doctors and endocrinologists are already using the technology in their clinics, and have expressed great satisfaction. After all, in addition to saving lives and improving quality of life, AEYE Healths technologies also encourage current practitioners to become more specialized and perform more intricate tasks for their patients.I never imagined that in my lifetime such a technology would come into existence; one that would be able to scan eyes for diseases by using almost any camera, from cheap manual scanners to large complicated machines worth tens of thousands of dollars.AEYE is solving a challenge we have all experienced in one way or another: diagnosing medical conditions effectively. The fact that this company is able to do this using our eyes alone is just mind-boggling, and gives me real hope for the future of diagnostics and healthcare in general.

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HILLEL'S TECH CORNER: Making the eyes the windows of disease diagnostics - The Jerusalem Post

Birdsong offers clues to the workings of short-term memory – AroundtheO

When a canary sings, it maintains a memory trace of the notes produced in the previous five to 10 seconds, a process that allows the bird to produce songs with long-range rules or syntactic structure, according to a new study co-written by a neuroscientist at the University of Oregons Phil and Penny Knight Campus for Accelerating Scientific Impact.

In the project, a nine-member team used tiny, head-mounted microscopes to track the activity of the output neurons that reside in a canarys high vocal center, a brain area involved in song motor control. In prior studies, the activity of these neurons had been identified in simpler singers, revealing one of the most precise patterns of neural activity observed in any organism.

Newly applied to the more complex song of canaries, the neurons were seen activating in specific sequential contexts, with the rules of activation spanning up to 40 syllables over four seconds. The teams paper was published online June 17 by the journal Nature.

The research opens a window on theorized hidden states of the brain, a form of short-term memory that integrates past information with ongoing motor control, said Tim Gardner, an associate professor and the DeArmond Chair in Neuro-Engineering in the Knight Campus.

Studying short-term motor memory in canaries provides an opportunity to examine a high-level motor phenomenon in a controlled model system, one that is akin to how studies of the hydrogen atom helped crack the code of quantum mechanics at its inception, Gardner said.

You want to examine a new phenomenon using the simplest possible model that captures the essence of the problem, he said. We often think of songbirds in a similar way. Birdsong is a very quantifiable behavior. Sensory motor learning is 50 percent or more of what brains are all about. Its learning to integrate sensation and action to effectively control movements, in this case, vocalizations.

Songbirds are known to form detailed sensory memories for their tutor songs, and to use the memories to guide the development of their own song to match the tutor over many months. However, until the new study there was no evidence for short-term memory of song that could form a substrate for more complex song rules.

Gardner and Yarden Cohen, then a postdoctoral student and the studys lead author, began the fundamental research in Gardners Boston University lab before Gardner joined the Knight Campus in June 2019. Analyses of the data continued under Gardners tutelage after his arrival at the UO, where he also is affiliated with the Department of Physics.

These birds produce songs that contain hundreds of syllables organized in a way that indicates that they are using the short-term memory of preceding song syllables to guide the choice of the next elements in song, said Cohen, now a neurosurgery research fellow at Massachusetts General Hospital, which is affiliated with the Harvard Medical School.

They create a complex syntax with long-range rules resembling properties of human behaviors like speech, dance and playing a musical instrument, Cohen said. We discovered that their song circuitry reflects the working memory required for their complex syntax.

The research, Gardner said, delivers a new way to study the principles of short-term memory.

If you reflect on the nature of speech, the choice of what to say next is guided by working memory that integrates over many timescales, from the overall aim of the communication episode to the local rules required for proper grammatical form, Gardner said. Canary song is much simpler, but it follows long-range syntax rules such as sing syllable D only if five seconds ago I sang A rather than B.

This deep structure, he said, contains simple similarities to speech where the ending of a sentence is dependent on how the sentence began. In both systems, correlations between past and future parts of the vocalization require a form of short-term memory.

What is clear is that a lot of cellular rules that underlie learning and memory are highly conserved, Gardner said. For example, there are cells in the basal ganglia in songbirds that have incredibly similar patterns of activity to what has been seen in rodents. While brain architecture may differ, the fundamental computations expressed at a cellular level are the same.

Gardner will continue to use the tools used in the study for his work in his Knight Campus lab. Ideally, he said, it could lead to not just to improved understanding of complex behaviors but also to enhanced machine-learning methods.

A lot of what we see in the canary resembles computational models that have been used for speech recognition and general artificial intelligence algorithms, he said. Speech algorithms used in Siri and Google Assistant networks use these types of hidden states seen in the canaries.

Eventually, Cohen said, studying the neural basis of canary song production may make it possible to understand how working memory mechanisms adapt to new conditions or fail when brain circuits are damaged. Developing such a model, he added, may point to new therapies for speech and comprehension deficits that come with aging and in neurodegenerative diseases such as Parkinsons and Alzheimers.

Five grants from the National Institutes of Health supported the research team, which in addition to Gardner and Cohen included seven other members drawn from Boston Universitys biology department and medical school.

By Jim Barlow, University Communications

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Birdsong offers clues to the workings of short-term memory - AroundtheO

30 Years Ago, Romania Deprived Thousands of Babies of Human Contact – The Atlantic

Image above: Izidor Ruckel near his home outside Denver

For his first three years of life, Izidor lived at the hospital.

The dark-eyed, black-haired boy, born June 20, 1980, had been abandoned when he was a few weeks old. The reason was obvious to anyone who bothered to look: His right leg was a bit deformed. After a bout of illness (probably polio), he had been tossed into a sea of abandoned infants in the Socialist Republic of Romania.

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In films of the period documenting orphan care, you see nurses like assembly-line workers swaddling newborns out of a seemingly endless supply; with muscled arms and casual indifference, they sling each one onto a square of cloth, expertly knot it into a tidy package, and stick it at the end of a row of silent, worried-looking papooses. The women dont coo or sing to the babies. You see the small faces trying to fathom whats happening as their heads whip by during the wrapping maneuvers.

In his hospital, in the Southern Carpathian mountain town of Sighetu Marmaiei, Izidor would have been fed by a bottle stuck into his mouth and propped against the bars of a crib. Well past the age when children in the outside world began tasting solid food and then feeding themselves, he and his age-mates remained on their backs, sucking from bottles with widened openings to allow the passage of a watery gruel. Without proper care or physical therapy, the babys leg muscles wasted. At 3, he was deemed deficient and transferred across town to a Cmin Spital Pentru Copii Deficieni, a Home Hospital for Irrecoverable Children.

The cement fortress emitted no sounds of children playing, though as many as 500 lived inside at one time. It stood mournfully aloof from the cobblestone streets and sparkling river of the town where Elie Wiesel had been born, in 1928, and enjoyed a happy childhood before the Nazi deportations.

The windows on Izidors third-floor ward had been fitted with prison bars. In boyhood, he stood there often, gazing down on an empty mud yard enclosed by a barbed-wire fence. Through bare branches in winter, Izidor got a look at another hospital that sat right in front of his own and concealed it from the street. Real children, children wearing shoes and coats, children holding their parents hands, came and went from that hospital. No one from Izidors Cmin Spital was ever taken there, no matter how sick, not even if they were dying.

Like all the boys and girls who lived in the hospital for irrecoverables, Izidor was served nearly inedible, watered-down food at long tables where naked children on benches banged their tin bowls. He grew up in overcrowded rooms where his fellow orphans endlessly rocked, or punched themselves in the face, or shrieked. Out-of-control children were dosed with adult tranquilizers, administered through unsterilized needles, while many who fell ill received transfusions of unscreened blood. Hepatitis B and HIV/AIDS ravaged the Romanian orphanages.

Izidor was destined to spend the rest of his childhood in this building, to exit the gates only at 18, at which time, if he were thoroughly incapacitated, hed be transferred to a home for old men; if he turned out to be minimally functional, hed be evicted to make his way on the streets. Odds were high that he wouldnt survive that long, that the boy with the shriveled leg would die in childhood, malnourished, shivering, unloved.

This past Christmas Day was the 30th anniversary of the public execution by firing squad of Romanias last Communist dictator, Nicolae Ceauescu, whod ruled for 24 years. In 1990, the outside world discovered his network of child gulags, in which an estimated 170,000 abandoned infants, children, and teens were being raised. Believing that a larger population would beef up Romanias economy, Ceauescu had curtailed contraception and abortion, imposed tax penalties on people who were childless, and celebrated as heroine mothers women who gave birth to 10 or more. Parents who couldnt possibly handle another baby might call their new arrival Ceauescus child, as in Let him raise it.

Read: Ta-Nehisi Coates on Nicolae Ceauescu, megalomaniacal tyrant, friend of America

To house a generation of unwanted or unaffordable children, Ceauescu ordered the construction or conversion of hundreds of structures around the country. Signs displayed the slogan: the state can take better care of your child than you can.

At age 3, abandoned children were sorted. Future workers would get clothes, shoes, food, and some schooling in Case de copiichildrens homeswhile deficient children wouldnt get much of anything in their Cmine Spitale. The Soviet science of defectology viewed disabilities in infants as intrinsic and uncurable. Even children with treatable issuesperhaps they were cross-eyed or anemic, or had a cleft lipwere classified as unsalvageable.

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After the Romanian revolution, children in unspeakable conditionsskeletal, splashing in urine on the floor, caked with feceswere discovered and filmed by foreign news programs, including ABCs 20/20, which broadcast Shame of a Nation in 1990. Like the liberators of Auschwitz 45 years before, early visitors to the institutions have been haunted all their lives by what they saw. We flew in by helicopter over the snow to Siret, landing after midnight, subzero weather, accompanied by Romanian bodyguards carrying Uzis, Jane Aronson tells me. A Manhattan-based pediatrician and adoption-medicine specialist, she was part of one of the first pediatric teams summoned to Romania by the new government. We walk into a pitch-black, freezing-cold building and discover there are youngsters lurking abouttheyre tiny, but older, something weird, like trolls, filthy, stinking. Theyre chanting in a dronelike way, gibberish. We open a door and find a population of cretinsnow its known as congenital iodine deficiency syndrome; untreated hypothyroidism stunts growth and brain development. I dont know how old they were, three feet tall, could have been in their 20s. In other rooms we see teenagers the size of 6- and 7-year-olds, with no secondary sexual characteristics. There were children with underlying genetic disorders lying in cages. You start almost to disassociate.

I walked into an institution in Bucharest one afternoon, and there was a small child standing there sobbing, recalls Charles A. Nelson III, a professor of pediatrics and neuroscience at Harvard Medical School and Boston Childrens Hospital. He was heartbroken and had wet his pants. I asked, Whats going on with that child? A worker said, Well, his mother abandoned him this morning and hes been like that all day. That was it. No one comforted the little boy or picked him up. That was my introduction.

The Romanian orphans were not the first devastatingly neglected children to be seen by psychologists in the 20th century. Unresponsive World War II orphans, as well as children kept isolated for long periods in hospitals, had deeply concerned mid-century child-development giants such as Ren Spitz and John Bowlby. In an era devoted to fighting malnutrition, injury, and infection, the idea that adequately fed and medically stable children could waste away because they missed their parents was hard to believe. Their research led to the then-bold notion, advanced especially by Bowlby, that simply lacking an attachment figure, a parent or caregiver, could wreak a lifetime of havoc on mental and physical health.

From the April 1996 issue: Anne F. Thurston describes life in a Chinese orphanage

Neuroscientists tended to view attachment theory as suggestive and thought-provoking work within the soft science of psychology. It largely relied on case studies or correlational evidence or animal research. In the psychologist Harry Harlows infamous maternal deprivation experiments, he caged baby rhesus monkeys alone, offering them only maternal facsimiles made of wire and wood, or foam and terry cloth.

In 1998, at a small scientific meeting, animal research presented back-to-back with images from Romanian orphanages changed the course of the study of attachment. First the University of Minnesota neonatal-pediatrics professor Dana Johnson shared photos and videos that hed collected in Romania of rooms teeming with children engaged in motor stereotypies: rocking, banging their heads, squawking. He was followed by a speaker who showed videos of her work with motherless primate infants like the ones Harlow had producedswaying, twirling, self-mutilating. The audience was shocked by the parallels. We were all in tears, Nelson told me.

In the decade after the fall of Ceauescu, the new Romanian government welcomed Western child-development experts to simultaneously help and study the tens of thousands of children still warehoused in state care. Researchers hoped to answer some long-standing questions: Are there sensitive periods in neural development, after which the brain of a deprived child cannot make full use of the mental, emotional, and physical stimulation later offered? Can the effects of maternal deprivation or caregiver absence be documented with modern neuroimaging techniques? Finally, if an institutionalized child is transferred into a family setting, can he or she recoup undeveloped capacities? Implicitly, poignantly: Can a person unloved in childhood learn to love?

Tract developments fan out from the Denver airport like playing cards on a table. The Great Plains have been ground down to almost nothing here, to wind and dirt and trash on the shoulder of the highway, to Walgreens and Arbys and AutoZone. In a rental car, I drive slowly around the semicircles and cul-de-sacs of Izidors subdivision until I see him step out of the shadow of a 4,500-square-foot McMansion with a polite half-wave. He sublets a room here, as do others, including some familiesan exurban commune in a single-family residence built for Goliaths. At 39, Izidor is an elegant, wiry man with mournful eyes. His manner is alert and tentative. A general manager for a KFC, he works 60-to-65-hour weeks.

Read: American child detention centers degrading, inhumane conditions

Welcome to Romania, he announces, opening his bedroom door. Its an entryway into another time, another place. From every visit to his home country, Izidor has brought back folk art and souvenirshand-painted glazed plates and teacups, embroidered tea towels, Romanian flags, shot glasses, wood figurines, cut-glass flasks of plum brandy, and CDs of Romanian folk music, heavy on the violins. He could stock a gift shop. There are thick wine-colored rugs, blankets, and wall hangings. The ambient light is maroon, the curtains closed against the high-altitude sunshine. Ten miles southwest of the Denver airport, Izidor is living in an ersatz Romanian cottage.

Everyone in Maramure lives like this, he tells me, referring to the cultural region in northern Romania where he was born.

Im thinking, Do they, though?

You will see that many people there have these things in their homes, he clarifies.

That sounds more accurate. People like knickknacks. Do you sound like a Romanian when you visit? I ask.

No, he says. When I start to speak, they ask, Where are you from? I tell them: From Maramure! No one believes him, because of his accent, so he has to explain: Technically, if you want to be logical about it, I am Romanian, but Ive lived in America for more than 20 years.

When you meet new people, do you talk about your history?

No, I try not to. I want to experience Romania as a normal human being. I dont want to be known everywhere as the Orphan.

His precise English makes even casual phrases sound formal. In his room, Izidor has captured the Romanian folk aesthetic, but something else stirs beneath the surface. Im reminded of the book he self-published at age 22, titled Abandoned for Life. Its a grim tale, but once, when he was about 8, Izidor had a happy day.

A kind nanny had started working at the hospital. Onisa was a young lady, a bit chubby, with long black hair and round rosy cheeks, Izidor writes in his memoir. She loved to sing and often taught us some of her music. One day, Onisa intervened when another nanny was striking Izidor with a broomstick. Like a few others before her, Onisa had spotted his intelligence. On the ward of semi-ambulatory (some crawled or creeped), slightly verbal (some just made noises) children, Izidor was the go-to kid if an adult had questions, like what was that ones name or when had that one died. The director would occasionally peek in and ask Izidor if he and the other children were being hit; to avoid retribution, Izidor always said no.

Annie Lowrey: How America treats its own children

On that day, to cheer him up after his beating, Onisa promised that someday shed take him home with her for an overnight visit. Skeptical that such an extraordinary event would ever happen, Izidor thanked her for the nice idea.

A few weeks later, on a snowy winter day, Onisa dressed Izidor in warm clothes and shoes shed brought from home, took him by the hand, and led him out the front door and through the orphanage gate. Walking slowly, she took the small boy, who swayed on uneven legs with a deep, tilting limp, down the lane past the public hospital and into the town. Cold, fresh air brushed his cheeks, and snow squeaked under his shoes; the wind rattled the branches; a bird stood on a chimney. It was my first time ever going out into the world, he tells me now. He looked in astonishment at the cars and houses and shops. He tried to absorb and memorize everything to report back to the kids on his ward.

When I stepped into Onisas apartment, he writes, I could not believe how beautiful it was; the walls were covered with dark rugs and there was a picture of the Last Supper on one of them. The carpets on the floor were red. Neighborhood children knocked on Onisas door to see if the strange boy from the orphanage wanted to come out and play, and he did. Onisas children arrived home from school, and Izidor learned that it was the start of their Christmas holiday. He feasted alongside Onisas family at their friends dinner table that night, tasting Romanian specialties for the first time, including sarmale (stuffed cabbage), potato goulash with thick noodles, and sweet yellow sponge cake with cream filling. He remembers every bite. On the living-room floor after dinner, the child of that household let Izidor play with his toys. Izidor followed the boys lead and drove little trains across the rug. Back at Onisas, he slept in his first-ever soft, clean bed.

The next morning, Onisa asked Izidor if he wanted to go to work with her or to stay with her children. Here he made a mistake so terrible that, 31 years later, he still remembers it with grief.

I want to go to work with you! he called. He was deep into a fantasy that Onisa was his mother, and he didnt want to be parted from her. I got dressed as fast as I could, and we headed out the door, he remembers. When we were near her work, I realized that her work was at the hospital, my hospital, and I began to cry It had only been 24 hours but somehow I thought I was going to be part of Onisas family now. It didnt occur to me that her work was actually at the hospital until we were at the gate again. I felt so shocked when we turned into the yard it was like Id forgotten I came from there.

He tried to turn back but wasnt permitted. Hed found the most wonderful spot on EarthOnisas apartmentand, through his own stupidity, had let it slip away. He sobbed like a newcomer until the other nannies threatened to slap him.

Today Izidor lives 6,000 miles from Romania. He leads a solitary life. But in his bedroom in a subdivision on a paved-over prairie, he has re-created the setting from the happiest night in his childhood.

That night at Onisas, I ask, do you think you sensed that there were family relationships and emotions happening there that youd never seen or felt before?

No, I was too young to perceive that.

But you did notice the beautiful furnishings?

Yes! You see this? Izidor says, picking up a tapestry woven with burgundy roses on a dark, leafy background. This is almost identical to Onisas. I bought it in Romania for that reason!

All these things I gesture.

Yes.

But not because they signify family to you?

No, but they signify peace to me. It was the first time I slept in a real home. For many years I thought, Why cant I have a home like that?

Now he does. But he knows there are missing partsno matter how many shot glasses he collects.

In the early 1990s, Danny and Marlys Ruckel lived with their three young daughters in a San Diego condo. They thought it would be nice to add a boy to the mix, and heard about a local independent filmmaker, John Upton, who was arranging adoptions of Romanian orphans. Marlys called and told him they wanted to adopt a baby boy. Theres thousands of kids there, Upton replied. Thatll be easy.

Marlys laughs. Not much of that was accurate! she tells me. Were seated in the living room of a white-stucco house in the Southern California wine-country town of Temecula. Kids and dogs bang in and out of the dazzling hot day (the Ruckels have adopted five children from foster care in recent years). Marlys, now a job coach for adults with special needs, is like a Diane Keaton character, shyly retreating behind large glasses and a fall of long hair, but occasionally making brave outbursts. Danny, a programmer, is an easygoing guy. Marlys describes herself as a homebody, but then there was that time she moved to Romania for two months to try to adopt a boy she saw on a video.

Undone by Shame of a Nation, Upton had flown to Romania four days after the broadcast, and made his way to the worst place on the show, the Home Hospital for Irrecoverable Children in Sighetu Marmaiei. He went back a few times. On one visit, he gathered a bunch of kids in an empty room to film them for prospective adoptive parents. His video would not show children packed together naked like little reptiles in an aquarium, as hed described them, but as people, wearing clothes and speaking.

By then, donations had started to come in from charities around the world. Little reached the children, because the staff skimmed the best items, but on that day, in deference to the American, nannies put donated sweaters on the kids. Though the children seemed excited to be the center of attention, Upton and his Romanian assistant found it slow-going. Some didnt speak at all, and others were unable to stand up or to stand still. When the filmmakers asked for the childrens names and ages, the nannies shrugged.

At the end of a wooden bench sat a boy the size of a 6-year-oldat age 10, Izidor weighed about 50 pounds. Upton was the first American hed ever seen. Izidor knew about Americans from the TV show Dallas. A donated television had arrived one day, and he had lobbied for this one thing to stay at the hospital. The director had assented. On Sunday nights at 8 oclock, ambulatory kids, nannies, and workers from other floors gathered to watch Dallas together. When rumors flew up the stairs that day that an American had arrived, the reaction inside the orphanage was, Almighty God, someone from the land of the giant houses!

Izidor knew the information the nannies didnt. He tells me: John Upton would ask a kid, How old are you?, and the kid would say, I dont know, and the nanny would say, I dont know, and Id yell, Hes 14! Hed ask about another kid, Whats his last name?, and Id yell, Dumka!

Izidor knows the children here better than the staff, Upton grouses in one of the tapes. Before wrapping up the session, he lifts Izidor into his lap and asks if hed like to go to America. Izidor says that he would.

Back in San Diego, Upton told the Ruckels about the bright boy of about 7 who hoped to come to the United States. Wed wanted to adopt a baby, Marlys says. Then we saw Johns video and fell in love with Izidor.

In May 1991, Marlys flew to Romania to meet the child and try to bring him home. Just before traveling, she learned that Izidor was almost 11, but she was undaunted. She traveled with a new friend, Debbie Principe, who had also been matched with a child by Upton. In the directors office, Marlys waited to meet Izidor, and Debbie waited to meet a little blond live wire named Ciprian.

When Izidor entered, Marlys says, all I saw was him, like everything else was fuzzy. He was as beautiful as Id imagined. Our translator asked him which of the visitors in the office he hoped would be his new mother, and he pointed to me!

Izidor had a question for the translator: Where will I live? Is it like Dallas?

Well no, we live in a condo, like an apartment, Marlys said. But youll have three sisters. Youll love them.

This did not strike Izidor as an interesting trade-off. He dryly replied to the translator: We will see.

That night, Marlys rejoiced about what an angel Izidor was.

Debbie laughed. He struck me more like a cool operator, a savvy politician type, she told Marlys. He was much more on top of things than Chippy. Ciprian had spent the time in the office rummaging wildly through everything, including desk drawers and the pockets of everyone in the room.

No, hes an innocent. Hes adorable, Marlys said. Did you see him pick me to be his mother?

Years later, in his memoir, Izidor explained that moment:

The pediatric neuroscientist Charles Nelson is famously gregarious and kind, with wavy, graying blond hair and a mustache like Captain Kangaroos. In the fall of 2000, he, along with his colleagues Nathan A. Fox, a human-development professor at the University of Maryland, and Charles H. Zeanah, a child-psychiatry professor at the Tulane University School of Medicine, launched the Bucharest Early Intervention Project. They had permission to work with 136 children, ages six months to 2.5 years, from six Bucharest leagne, baby institutions. None was a Home Hospital for Irrecoverable Children, like Izidors; they were somewhat better supplied and staffed.

By design, 68 of the children would continue to receive care as usual, while the other 68 would be placed with foster families recruited and trained by BEIP. (Romania didnt have a tradition of foster care; officials believed orphanages were safer for children.) Local kids whose parents volunteered to participate made up a third group. The BEIP study would become the first-ever randomized controlled trial to measure the impact of early institutionalization on brain and behavioral development and to examine high-quality foster care as an alternative.

To start, the researchers employed Mary Ainsworths classic strange situation procedure to assess the quality of the attachment relationships between the children and their caregivers or parents. In a typical setup, a baby between nine and 18 months old enters an unfamiliar playroom with her attachment figure and experiences some increasingly unsettling events, including the arrival of a stranger and the departure of her grown-up, as researchers code the babys behavior from behind a one-way mirror. Our coders, unaware of any childs background, assessed 100 percent of the community kids as having fully developed attachment relationships with their mothers, Zeanah told me. That was true of 3 percent of the institutionalized kids.

Nearly two-thirds of the children were coded as disorganized, meaning they displayed contradictory, jerky behaviors, perhaps freezing in place or suddenly reversing direction after starting to approach the adult. This pattern is the one most closely related to later psychopathology. Even more disturbing, Zeanah told me, 13 percent were deemed unclassified, meaning they displayed no attachment behaviors at all. Ainsworth and John Bowlby believed infants would attach to an adult even if the adult were abusive, he said. They hadnt considered the possibility of infants without attachments.

Until the Bucharest project, Zeanah said, he hadnt realized that seeking comfort for distress is a learned behavior. These children had no idea that an adult could make them feel better, he told me. Imagine how that must feelto be miserable and not even know that another human being could help.

In October 1991, Izidor and Ciprian flew with Romanian escorts to San Diego. The boys new families waited at the airport to greet them, along with Upton and previously adopted Romanian childrena small crowd holding balloons and signs, cheering and waving. Izidor gazed around the terminal with satisfaction. Where is my bedroom? he asked. When Marlys told him they were in an airport, not his new home, Izidor was taken aback. Though shed explained that the Ruckels did not live like the Ewings in Dallas, he hadnt believed her. Now hed mistaken the arrivals area for his new living room.

A 17-year-old from the orphanage, Izabela, was part of the airport welcoming committee. Born with hydrocephalus and unable to walk after being left all her life in a crib, she was in a wheelchair, dressed up and looking pretty. Rescued by Upton on an earlier trip, shed been admitted to the U.S. on a humanitarian medical basis and was being fostered by the Ruckels.

Izidor was startled to see Izabela: Who is your mother?

My mother is your mother, Izidor.

I didnt like the sound of that, he remembers. To make sure hed heard correctly, he asked again: Who is your mother here in America?

Izidor, you and I have the same mother, she said, pointing at Marlys.

So now he had to get used to four sisters.

In the car, when Danny tried to click a seat belt across Izidors waist, he bucked and yelled, fearing he was being straitjacketed.

Marlys homeschooled the girls, but Izidor insisted on starting fourth grade in the local school, where he quickly learned English. His canny ability to read the room put him in good stead with the teachers, but at home, he seemed constantly irritated. Suddenly insulted, hed storm off to his room and tear things apart. He shredded books, posters, family pictures, Marlys tells me, and then stood on the balcony to sprinkle the pieces onto the yard. If I had to leave for an hour, by the time I got home, everyone would be upset: He did this; he did that. He didnt like the girls.

Marlys and Danny had hoped to expand the family fun and happiness by bringing in another child. But the newest family member almost never laughed. He didnt like to be touched. He was vigilant, hurt, proud. By about 14, he was angry about everything, she tells me. He decided hed grow up and become the American president. When he found out that wouldnt be possible because of his foreign birth, he said, Fine, Ill go back to Romania. Thats when that startedhis goal of returning to Romania. We thought it was a good thing for him to have a goal, so we said, Sure, get a job, save your money, and when youre 18, you can move back to Romania. Izidor worked every day after school at a fast-food restaurant.

Those were rough years. I was walking on eggshells, trying not to set him off. The girls were so over it. It was me they were mad at. Not for bringing Izidor into the family but for being so so whipped by him. Theyd say, Mom, all you do is try to fix him! I was so focused on helping him adjust, I lost sight of the fact that the other children were scraping by with a fraction of my time.

Danny and I tried taking him to therapy, but he refused to go back. He said, I dont need therapy. You two need therapy. Why dont you go? So we did.

Hed say: Im fine when nobodys in the house.

Wed say: But Izidor, its our house.

As early as 2003, it was evident to the BEIP scientists and their Romanian research partners that the foster-care children were making progress. Glimmering through the data was a sensitive period of 24 months during which it was crucial for a child to establish an attachment relationship with a caregiver, Zeanah says. Children taken out of orphanages before their second birthday were benefiting from being with families far more than those who stayed longer. When youre doing a trial and your preliminary evidence is that the intervention is effective, you have to ask, Do we stop now and make the drug available to everyone? he told me. For us, the effective drug happened to be foster care, and we werent capable of creating a national foster-care system. Instead, the researchers announced their results publicly, and the next year, the Romanian government banned the institutionalization of children under the age of 2. Since then, it has raised the minimum age to 7, and government-sponsored foster care has expanded dramatically.

Meanwhile, the study continued. When the children were reassessed in a strange situation playroom at age 3.5, the portion who displayed secure attachments climbed from the baseline of 3 percent to nearly 50 percent among the foster-care kids, but to only 18 percent among those who remained institutionalizedand, again, the children moved before their second birthday did best. Timing is critical, the researchers wrote. Brain plasticity wasnt unlimited, they warned. Earlier is better.

The benefits for children whod achieved secure attachments accrued as time went on. At age 4.5, they had significantly lower rates of depression and anxiety and fewer callous unemotional traits (limited empathy, lack of guilt, shallow affect) than their peers still in institutions. About 40 percent of teenagers in the study whod ever been in orphanages, in fact, were eventually diagnosed with a major psychiatric condition. Their growth was stunted, and their motor skills and language development stalled. MRI studies revealed that the brain volume of the still-institutionalized children was below that of the never institutionalized, and EEGs showed profoundly less brain activity. If you think of the brain as a light bulb, Charles Nelson has said, its as though there was a dimmer that had reduced them from a 100-watt bulb to 30 watts.

One purpose of a baby attaching to just a small number of adults, according to evolutionary theory, is that its the most efficient way to get help. If there were many attachment figures and danger emerged, the infant wouldnt know to whom to direct the signal, explains Martha Pott, a senior lecturer in child development at Tufts. Unattached children see threats everywhere, an idea borne out in the brain studies. Flooded with stress hormones like cortisol and adrenaline, the amygdalathe main part of the brain dealing with fear and emotionseemingly worked overtime in the still-institutionalized children.

Comparing data from orphanages worldwide shows the profound impact institutionalization has on social-emotional development even in the best cases. In Englands residential nurseries in the 1960s, there was a reasonable number of caregivers, and the children were materially well provided for. Their IQs, though lower than those of children in families, were well within the average range, up in the 90s, Zeanah told me. More recently, the caregiver-child ratio in Greek orphanages was not as good, nor were they as materially well equipped; those kids had IQs in the low-average range. Then, in Romania, you have our kids with really major-league deficits. But heres the remarkable thing: Across all those settings, the attachment impairments are similar.

When the children in the Bucharest study were 8, the researchers set up playdates, hoping to learn how early attachment impairments might inhibit a childs later ability to interact with peers. In a video I watched, two boys, strangers to each other, enter a playroom. Within seconds, things go off the rails. One boy, wearing a white turtleneck, eagerly seizes the other boys hand and gnaws on it. That boy, in a striped pullover, yanks back his hand and checks for teeth marks. The researcher offers a toy, but the boy in white is busy trying to hold hands with the other kid, or grab him by the wrists, or hug him, as if he were trying to carry a giant teddy bear. He tries to overturn the table. The other boy makes a feeble effort to save the table, then lets it fall. Hes weird, you can imagine him thinking. Can I go home now?

The boy in the white turtleneck lived in an institution; the boy in the striped pullover was a neighborhood kid.

Nelson cautions that the door doesnt slam shut for children left in institutions beyond 24 months of age. But the longer you wait to get children into a family, he says, the harder it is to get them back on an even keel.

Every time we got into another fight, Izidor remembers, I wanted one of them to say: Izidor, we wish we had never adopted you and we are going to send you back to the hospital. But they didnt say it.

Unable to process his familys affection, he just wanted to know where he stood. It was simpler in the orphanage, where either you were being beaten or you werent. I responded better to being smacked around, Izidor tells me. In America, they had rules and consequences. So much talk. I hated Lets talk about this. As a child, Id never heard words like You are special or Youre our kid. Later, if your adoption parents tell you words like that, you feel, Okay, whatever, thanks. I dont even know what youre talking about. I dont know what you want from me, or what Im supposed to do for you. When banished to his room, for rudeness or cursing or being mean to the girls, Izidor would stomp up the stairs and blast Romanian music or bang on his door from the inside with his fists or a shoe.

Marlys blamed herself. He said he wanted to go back to his first mother, a woman who hadnt even wanted him, a woman he didnt remember. When I took him to the bank to set up his savings account, the bank official filling out the form asked Izidor, Whats your mothers maiden name? I opened my mouth to answer, but he immediately said Maria. Thats his birth mothers name. I know it was probably dumb to feel hurt by that.

One night when Izidor was 16, Marlys and Danny felt so scared by Izidors outburst that they called the police. Im going to kill you! hed screamed at them. After an officer escorted Izidor to the police car, he insisted that his parents abused him.

Oh, for Christs sake, Danny said when informed of his sons accusation.

Continued here:
30 Years Ago, Romania Deprived Thousands of Babies of Human Contact - The Atlantic

Ditch Factory Farms: Health Experts Say Pandemic Is Telling Humanity To End Animal Agriculture – Green Queen Media

A new editorial article authored by leading academic physicians from the US to New Zealand says that the coronavirus pandemic is showing humanity that unsustainable and dangerous factory farming must be phased out for alternative proteins. While acknowledging the role of the wildlife industry, which they say must be eradicated as well, the experts believe that ultimately, the intensive factory farming industry and global appetite for animal meat should be discontinued in order to prevent future pandemics.

The paper, published in peer-reviewed journal Neuroepidemiology, was authored by Mayo Clinic Emeritus Professor David O. Wiebers, MD., and neuroscience professor at Auckland University of Technology and editor-in-chief of Neuroepidemiology Valery Feigin.

As we begin to find our way through this crisis, it is imperative for us as a society and species to focus and reflect deeply upon what this and other related human health crises are telling us about our role in these increasingly frequent events and about what we can do to avoid them in the future, wrote Weibers and Feigin.

Although it is tempting for us to lay the blame for pandemics such as COVID-19 on bats, pangolins, or other wild species, it is human behavior that is responsible for the vast majority of zoonotic diseases that jump the species barrier from animals to humans.

The experts detailed the relation between the alarming increase in frequency of deadly zoonotic diseases to the unnaturally close contact between animals and humans due to humanitys continued exploitation of nature and animals for human purposes.

From destruction of animal habitats to overcrowded factory farms, the authors believe that continuing such practices will mean that more deadly pandemics are on the horizon.

While acknowledging the role of the hunting and selling of wild animals as a key public health risk that must be eliminated, the paper also points to the global livestock industry that has exploded in the past decades due to humanitys appetite for meat.

Over the last 40 years, as the factory farm model has become a global phenomenonNow, serious outbreaks are occurring regularly more in the past 15 years than in the entire 20th century.

It points out that livestock farming not only raises the threat of emerging infectious diseases, but also contributes to habitat destruction, deforestation and greenhouse gases that further exacerbate climate change all of which are factors cycling back to increase the likelihood of deadly pandemics.

Read: Pandemic Meat Crisis Pushes Consumers Towards Plant-Based Alternatives From HK To US

Intensive confinement of animals in factory farm operations should be discontinued worldwide for the sake of animals, humans, and the environment, and we should rapidly evolve to eating other forms of protein that are safer for humans, including plant-based meat alternatives and cultured meat, they wrote.

Additional investment in plant-based agriculture to grow crops to feed humans rather than livestock for human consumption would feed more people while utilising far less land and water, allowing for the preservation of vital ecosystems for innumerable species.

Similar warnings have been issued by other scientific experts in recent months. In an article published in late April, the worlds leading wildlife and biodiversity scientists said that the combination of global air travel, unsustainable urbanisation and industrial livestock farming has created a perfect storm for haunting diseases.

The experts cautioned that while trillion-dollar packages now being implemented are necessary measures, they cannot come at the cost of failing to enforce environmental protection, which would make future pandemics happen more rapidly, frequently and with even more destructive consequences.

Lead image courtesy of Friso Gentsch / DPA / AFP via Getty Images.

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Ditch Factory Farms: Health Experts Say Pandemic Is Telling Humanity To End Animal Agriculture - Green Queen Media

Global inequality and exploitation – Daily Times

Around the world, inequality is a significant determinant of human behavior, opening doors of opportunity to some and closing them to others. A very few centuries ago, such Vast divides in global wealth did not exist. Except for a very few rulers and land Owners everyone in the world was poor. In much of Europe, life was as difficult as it was in Asia or South America. This was true until the industrial revolution and rising agricultural productivity produced explosive economic growth. The resulting rise in the living standards was not evenly distributed across the world.

In 2005 the United Nations launched the millennium project whose objective is to eliminate poverty and to raise the level and standard of living of the people. Industrial nations had the role and goal to set aside a percentage of their gross national product (GNP) for aid to developing nations.

While the divide between industry and developing nations was sharp, sociologists recognize a continuum of nations, from the richest of the rich to the poorest of the poor. Three forces considered responsible, particularly for the domination of the world marketplace by a few nations were the legacy of colonialism; the advent of the multinational companies and modernization.

Relations between the colonial nation and colonized people are similar to those between the dominant capitalist class and the proletariat, as described by Karl Marx.

By the 1980s, colonialism had largely disappeared. For colonies having achieved political independence and established their own governments the complete transition to genuine self-rule was essential to leave behind the established patterns of economic exploitation. Former colonies were unable to develop their own industry and technology. Their dependence on more industrialized nations, including their former colonial masters, for managerial and technical expertise, investment capital, and manufactured goods kept former colonies in a subservient position. Such continuing dependence and foreign domination are referred to as neocolonialism.

Some observers see globalization and its effects as the natural result of advances in communications technology, particularly the Internet and satellite transmission of the mass media

The economic and political consequences of colonialism and neocolonialism are readily apparent. Drawing on the conflict perspective, sociologist Immanuel Wallenstein (1974, 1979 a, 2000) views the global economic system as being divided between nations that control wealth and nations from which resources are taken. Through his world systems analysis, Wallenstein has described the unequal economic and political relationships in which certain industrialized nations (among them the United States, Japan, and Germany) and their global corporations dominate the core of this system. Ultimately it is the exploitative relationship of core nations toward non core nation. Core nations and their corporations control and exploit noncore nations economies.

In the view of world Systems analysis and dependency theory, a growing Share of human and natural resources of developing Countries is being redistributed to the Core industrialized nations. This redistribution happens in part because developing countries owe huge sums of money to industrialized nations as a result of foreign aid, loans, and trade deficits. The global debt crisis has intensified the Third World dependency begun under colonialism, neocolonialism and multinational investment. International financial institutions are pressuring indebted Countries to take severe measures to meet their interest payments. The result is that developing nations may be forced to devalue their currencies, freeze Workers wages, increase privatization of industry, and reduce government services and employment.

Closely related to these problems is globalization, the worldwide integration of government policies, cultures and social movements and financial markets through trade and the exchange of ideas. Because World financial markets transcend Governance by conventional nation states, international organizations such as the World Bank and International Monetary Fund have emerged as major players in the global economy. The function of these institutions which are heavily funded and influenced by Core nations, is to encourage economic trade and development and to ensure the smooth operation of international financial markets. As such, they are seen as promoters of globalization and defenders primarily of interests of Core nations.

Critics call attention to a variety of issues, including violations of workers rights, the destruction of the environment, the loss of cultural identity and discrimination against minority groups in periphery nations.

Some observers see globalization and its effects as the natural result of advances in communications technology, particularly the Internet and satellite transmission of the mass media. Others view it more critically as a process that allows multinational corporations to expand unchecked.

Conflict theorists challenge the favorable evaluation of the impact of multinational corporations. They emphasize the multinationals exploit local workers to maximize profit. The pool of cheap labor in the developing world prompts multinationals to move factories out of core countries.

The writer is former Director National Institute of Public Administration (NIPA) Government of Pakistan, a political analyst, a public policy expert

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Global inequality and exploitation - Daily Times

Widely cited health institute keeps missing the mark on Maine death projections – Press Herald

A research group that has been widely cited by national health experts and government officials for its COVID-19 models has twice projected enormous increases in COVID-19 deaths in Maine.

But in both cases, the Institute for Health Metrics and Evaluation at the University of Washington published new data within a matter of days that sharply reduced its projected death counts.

The institute published projections last week that Maine could surpass 1,000 COVID-19 deaths by the fall a 10-fold increase over current deaths but revised that figure to less than 200 deaths just five days later. And in March, the institute published a projection of more than 3,000 deaths in Maine by August, only to lower that figure to 334 deaths a few days later, after making adjustments to its data.

The wildly different death projections over the course of less than a week raises questions about the value of the modeling and spotlights the potential perils of relying on any one model to anticipate how the coronavirus could spread across the U.S.

Maines top public health epidemiologist, Dr. Nirav Shah, said he still lists the institute among the infectious disease modeling groups that he checks regularly as part of the Maine Center for Disease Control and Preventions own internal modeling exercises.

But the Maine CDC director added: It has diminished as a website that I check on a daily basis.

The institute is among dozens of academic and research groups trying to model how this new, somewhat unpredictable virus will spread across the globe. But IHMEs projections have been used by federal and state public health officials as they make decisions impacting the daily lives of nearly all Americans, as well as the economic health of the country.

Dr. Deborah Birx, the White Houses coronavirus response coordinator, has cited the IHME model several times, as have numerous governors. The institutes projections, both for the nation and individual states, are often quoted in news articles in a wide array of national publications.

On June 5, IHME released updated state-by-state and national forecasts that projected Maine could see 614 deaths by Sept. 21 six times higher than the current total of 101 deaths. A forecast from the institute in early April, by comparison, had projected Maine that could experience 115 COVID-related deaths by Aug. 1.

On June 10, the institutes projection for Maine jumped to 1,076 deaths. But in a June 15 update, IHME researchers slashed the projected number of deaths to 185 by Oct. 1.

Asked about the wild fluctuations over a period of just 10 days, an IHME spokeswoman attributed the swings to changes in Maines virus transmission rate. Also referred to as the reproduction rate or the R-naught, a transmission rate of 1 means that every person with COVID-19 would be expected to infect one other person, while a value of 3 means every person would infect three others.

The higher the number creeps above 1, even by decimal points, the faster the situation gets to a point where the virus is increasing exponentially to the point where hospitals and health care systems are overwhelmed.

In the earlier model, the modeling showed the transmission rate (R naught) going above 1, which leads to fast growth, Amelia Apfel wrote in an email. With the additional data in the latest update, we arent seeing that increase in transmission rate. The (institutes) models are pretty sensitive to this type of change.

Institute staff did not respond to requests for additional information on the data underlying the projections.

Shah, the Maine CDC director, said he saw the dramatic swings in IHMEs projections but attributed it to the institutes data sources and methodology, as well as Maines relatively small number of COVID-19 cases.

Maine did see an increase in its transmission rate several weeks ago, largely because of an outbreak at the Cape Memory Care nursing home in Cape Elizabeth. Over the course of a few days, Cape Memory went from zero cases to more than 60 among residents and staff as the Maine CDC helped test everyone at the facility.

Ultimately, Cape Memory Care had 84 cases with six deaths, to date. But Shah said models such as those run by IHME do not distinguish between isolated and contained outbreaks at facilities and a surge in cases in the community.

I kind of attributed them to statistical noise, Shah said Wednesday of the institutes surging death projections. What happens in Maine is what I call the law of small numbers.'

Shah said that Maine has very few cases compared to many other states, with his agency reporting 2,836 cases and 102 deaths as of Wednesday compared to a nationwide total of 2.1 million cases and 117,000 deaths. So when Maine reports 30 new confirmed or probable infections one day but 36 new cases the next day, Shah said, that equates to a 20 percent jump.

Shah said IHME relies largely on historical data, in this case, how COVID-19 spread, faded and may have surged again in other countries and more recently in the U.S. The institute said its most recent models also include such factors as testing rates, mobility data, mask use and population densities.

But while Shah said such models are useful and informative, comparing them to an almanac for weather projections, he has come to prefer more dynamic models that he compares to the supercomputers used by meteorologists to make weather forecasts. Those disease models take into account more things happening on the ground and, in some cases, individual policies at the state level.

But we dont use models to predict the future, Shah said. We use them to project scenarios that might happen and then respond accordingly.

IHMEs projections for Maine now fall within the range of more than a dozen other modeling organizations tracked by the U.S. Centers for Disease Control and Prevention. Those models which include projections from researchers at IHME, Johns Hopkins University, the Massachusetts Institute of Technology, UCLA, the University of Massachusetts and other institutions project Maine will experience between 103 and 151 deaths by July, with an ensemble average of between 115 and 123 depending on the confidence interval.

Shah stressed that modeling was a particularly important exercise early on as the state tried to gauge hospital capacity and critical care needs on a range of COVID-19 scenarios. But more than three months later, Maine has so far avoided uncontrolled transmission overwhelming the states health care system thanks, in large part, to physical distancing and other restrictions.

Maine CDC epidemiologists still consult outside models, including IHMEs projections, as they try to prepare for future scenarios. But the prime directives that influence decisions such as whether to lift or impose restrictions on businesses and people include metrics like the daily and rolling averages of new cases and deaths, hospitalization trends, testing rates and the percent of tests that come back positive.

Experts said, however, that models are valuable in infectious disease tracking even if they are inherently imprecise.

I think models get a bad rap because they are not perfectly, numerically precise, but that is just the nature of dealing with complex systems, said Chris Moore, an assistant professor of biology at Colby College.

That imprecision factor becomes even greater, Moore added, when you consider that the progression of COVID-19 and other infectious diseases is often dependent on unpredictable human behavior.

Moore, who taught courses last semester on the evolution of infectious disease and ecological modeling, said weather forecasts are often fairly precise in the short term and can generally predict, based on history, trends over the longer-term. The middle-range is more problematic.

Instead, Moore liked one of his students comparisons of infectious disease modeling to using a smartphone for driving directions. Your phones GPS should be able to predict with some precision when you will arrive in, say, nearby Fairfield from Waterville. But your ETA in Boston from Waterville depends on traffic, accidents and other factors.

When you are watching your phone and traveling, it is dynamically updating and taking into account all of these variables, Moore said.

Mathematical modeling expert Raj Saha said one of his major criticisms of COVID-19 modeling is that organizations need to be clearer about the underlying assumptions and data that are used to build the projections. For instance, the public should be able to clearly see and understand from non-scientific language whether a models projections take into account policies such as stay-at-home orders and other factors when they see the results.

Thats important because Saha, an interdisciplinary lecturer in environmental geophysics at Bates College, said people could change their behaviors based on projections, with potentially dire consequences during an outbreak of highly infectious disease.

People can look at low projections and assume things are OK, but they are OK because of the lockdown measures, Saha said.

Saha said he would rather see disease projections offer several scenarios based on easily understandable factors. As examples, Saha said one scenario could include a continuation of lockdown measures and physical distancing, another scenario where those measures are eased, and one with little or no restrictions.

Without knowing those assumptions, any projections, regardless of how sophisticated themodels are, can be interpreted in unintended ways, Saha said. We are all used to seeing weather projections for example the path of a hurricane which always comes with error zones. But how a public reacts to the projected paths of a hurricane is not going to affect the actual path of the hurricane. The same cannot be said here in the case of disease projections.

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Biomedicals big year: Grants fund research on skin, heart cells, cancer and more – Binghamton University

By Chris Kocher

June 18, 2020

The Thomas J. Watson School of Engineering and Applied Sciences Department of Biomedical Engineering has earned nearly $4 million in grants from 201820 (as of March 2020). Associate Professor Sha Jin alone received three grants totaling $1.2 million for her diabetes research. Funding agencies include the National Institutes of Health, the National Science Foundation and the National Institute of Standards and Technology.

Guy German

ASSOCIATE PROFESSOR

RESEARCH TOPIC: HUMAN SKIN

THE GOAL: Understanding how different factors can cause the mechanical properties of our skin to change. The human body has many barriers, and skin is arguably the most important, protecting us from the external environment. When skin becomes broken or ruptured, that barrier is lost. It can be caused by surgical incisions, penetrating trauma, diseases that cause lesions and chapping from cold environments. German explores how bacteria can degrade integrity; the effects of chronological- and photo-aging; and how to create bio-inspired materials that control crack propagation and the movement of fluids on their surfaces.

Tracy Hookway

ASSISTANT PROFESSOR

RESEARCH TOPIC: HEART CELLS

THE GOAL: Turning stem cells into functioning cardiac cells.

The human heart does not have the ability to repair itself after heart attacks or similar cardiac events. By merging the fields of stem-cell biology, tissue engineering and cardiovascular physiology, Hookway is trying to make models of cardiovascular tissue in a Petri dish that are more similar to what is in our bodies. One challenge is that the heart is not one cell type; in fact, it is multiple types of cells working together to achieve function.

Sha Jin

ASSOCIATE PROFESSOR

RESEARCH TOPIC: DIABETES

THE GOAL: Generating pancreatic tissue from stem cells.

One experimental treatment for diabetes currently in clinical trials through the U.S. Food and Drug Administration is islet transplantation, but there are fewer donors than needed. Human-induced pluripotent stem cells cells that can self-renew by dividing could offer a renewable source for islets, but they remain a challenge because of limited knowledge about how islets form. Jins lab has been working to direct stem cells to differentiate and mature into pancreatic islet organoids using a variety of approaches; when successful, these islets would be transplanted into humans.

Ahyeon Koh

ASSISTANT PROFESSOR

RESEARCH TOPIC: HUMAN SWEAT

THE GOAL: Utilizing sweat to generate electricity for flexible biosensors and to monitor stress levels.

Kohs research aims to give us real-time information about how our bodies are functioning, such as for glucose monitoring, wound care and post-surgery cardiac health. She is currently working with other Binghamton professors on two microfluidic systems that can collect and use the sweat that our body produces. One of them will have sweat-eating bacteria that will power biosensors, and the other will monitor stress levels by measuring the amounts of the steroid hormone cortisol that are secreted.

Gretchen Mahler

ASSOCIATE PROFESSOR

RESEARCH TOPIC: ORGAN-ON-A-CHIP

THE GOAL: Creating 3D microfluidic cell-culture chips that simulate the mechanics and physiological response of organs and tissues.

Mahlers current research which has applications for cardiovascular disease and cancer focuses on how disruptions in a tissues mechanical or chemical environment can lead to disease initiation and progression. She currently is working with three other professors two from Watson, one from Harpur College of Arts and Sciences on a National Science Foundation-funded study of calcific aortic valve disease, and she also is interested in how food additives alter gastrointestinal health.

Kaiming Ye

PROFESSOR AND DEPARTMENT CHAIR

RESEARCH TOPIC: CANCER VACCINE

THE GOAL: Developing a vaccine that will slow or halt the growth of future tumors.Yes research is targeting the protein CD47, which is part of the membrane that covers human cells. It also sends a dont eat me signal to a bodys immune system normally a good thing, but a problem when cells become cancerous. In a 2019 study using mice treated with their experimental vaccine, Ye and his co-investigators found a two-fold reduction in tumor growth rates and five-fold reduction in size in the tumors that did form.

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Biomedicals big year: Grants fund research on skin, heart cells, cancer and more - Binghamton University

Orca Bio Surfaces With $192M and Recipes for Custom Cell Therapies – Xconomy

XconomySan Francisco

The cancer cell therapies available today are made by tweaking a patients own immune cells to better recognize and fight the disease. Orca Bio is developing what it says is the next generation of cell therapy: custom preparations made without modifying cells or genes.

Orca is already testing its technology in humans, though it has kept that research mostly under wraps. As the startup prepares to reveal its preliminary findings and ramp up its manufacturing capability, the Menlo Park, CA-based biotechannounced on Wednesday the close of $192 million in financing.

The immune system is comprised of many cells that work in concert, says CEO Ivan Dimov. Some cells stimulate activity while other cells block it. But the effects of these immune cells can be dampened by the other cells around them. Orcas therapies are allogeneictheyre made by taking stem and immune cells from healthy donors rather than from the patients themselves, as is the case with autologous treatments. But rather than just taking those healthy cells and putting them into a patient, Orca chooses certain cells from the donor sample and combines them in specific ways. Dimov says each mixture, created from certain cell types that it has assembled in the proper ratio, forms a custom immune army that seeks out cancer cells and leaves healthy tissue alone.

Weve created a novel class of precision therapiesprecise, optimal therapeutic mixtures, he says.

Orcas first disease targets are aggressive blood cancers that require bone marrow transplants as a treatment of last resort. These procedures offer patients a potential cure, but they also come with risks, such as rejection by the immune system.

In recent years, cell therapy has emerged as a new option for aggressive blood cancers that havent responded to treatment. Chimeric antigen receptor T cell therapies, or CAR-Ts, are made by engineering a patients own T cells, multiplying them in a lab, and then infusing them back into the patient to target and fight the cancer. The first CAR-Ts that reached the market were developed by Novartis (NYSE: NVS) and Gilead Sciences (NASDAQ: GILD). These therapies pose the risk of a potentially fatal immune system reaction.

There are other biotechs that are trying to advance CAR-T therapy by making it safer and more scalable. Some of them, like Orca, are developing allogeneic cell therapies. Two such companies, Allogene Therapeutics (NASDAQ: ALLO) and Precision Biosciences (NASDAQ: DTIL), use gene editing to eliminate parts of an immune cell that could prompt an adverse response. Those companies are testing their respective therapies in clinical trials.

Dimov says Orcas custom therapies are meant to allow patients to avoid the complications associated with bone marrow transplants and CAR-T drugs. The descriptor custom needs a bit of clarification: An Orca therapy is not tailored to each patient, but rather customized to generate a particular therapeutic effect, Dimov says. If it works, the right mix not only provides the optimal treatment, it also avoids any adverse immune response. This approach offers a new way to reset and rebuild the immune system, Dimov says.

Orca has two programs in clinical trials. TRGFT-201 is a formulation of T cells and regulatory T cells (a type of cell that tamps down an immune response) that is in Phase 1/2 testing in patients with certain blood cancers. A second program, OGFT-0001, is a formulation of T cells that is in Phase 1, also in blood cancers. The new cash is expected to be enough for Orca to complete Phase 1 tests of the lead program, as well as build the startups manufacturing capacity.

Preliminary data from the studies have not yet been reported but Dimov says a terminally ill cancer patient who received one of the Orca therapies got well enough to leave the hospital. Anecdote aside, while full data are expected in 2022, some early findings are being prepared for peer review.

Orca traces its origins to the laboratory of Irv Weissman, director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine. Dimov joined Weissmans group in 2010 as the field of cell therapy was heating up. At that time, a central obstacle to its progress was figuring out how to make cell therapy manufacturing scalable. Meanwhile, the scientific communitys understanding of immune cells continued to advance. Orcas intellectual property covers both the cell therapy manufacturing technology, which offers the capability to sort stem and immune cells, and the therapeutic mixtures of cells. The startup spun out of Stanford in 2016 and started its first clinical trial about two years later, Dimov says.

Though cancer is Orcas focus for now, Dimov says the companys technology has potential applications in other diseases. Rare inherited disorders such as beta thalassemia and severe combined immunodeficiency are possible targets. Autoimmune diseases represent another opportunity. For each one, Orca would develop an appropriate mixture of immune and stem cells to treat the condition and restore immune system function, Dimov says.

Including the latest financing, Dimov says Orca has raised nearly $300 million. The new capital, a Series D round of funding, was co-led by Lightspeed Venture Partners and an unnamed investor. The other investors Orca has disclosed are 8VC, DCVC Bio, ND Capital, Abu Dhabi sovereign wealth fund Mubadala Investment Company, Kaiser Permanente, and the Illinois Municipal Retirement Fund.

Image: iStock/jonmccormackphoto

Frank Vinluan is an Xconomy editor based in Research Triangle Park. You can reach him at fvinluan@xconomy.com.

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Orca Bio Surfaces With $192M and Recipes for Custom Cell Therapies - Xconomy

Six tales from the trenches of running a startup – MIT Technology Review

Our company has built a platform to produce high-quality cells and tissues for regenerative medicine. That pursuit involves multiple disciplines, which means everyone here is an expert in a different language. Some of us are fluent in stem-cell biology, others in optical engineering, others in machine learning. When we started the company it wasnt possible to do biology and engineering under the same roof. When we finally moved into a shared space we were able to learn each others lexicons, and we became more strongly aligned. And now that were all working separately, the bonds created in that process have helped us deal with things. We cant discuss technical details at our desks anymore, but weve learned new ways of working together. Its important to stay in sync as a team, and in a covid-19 world thats never felt more true.

TIM O'CONNELL

Founded Blendoor, a job-search platform that hides candidates names and photos in the initial stages to reduce unconscious bias.

I started coding at 13, and that has gotten me pretty far in my career (Stanford, MIT, Microsoft). I once viewed humanities and social science education as nice-to-haves but not need-to-haves. It wasnt until I came face to face with the harsh realities of inequity and the paradox of meritocracy that I realized that artificial intelligence is far from solving many of our most challenging problems as a human race (for example, xenophobia, sexism, racism, homophobia, impostor syndrome, and unconscious bias).

The externalities that influence creativity, adoption, and scale are often more important than the innovation itself. To be a successful innovator one has to be really in tune with whats happening in the world on a global scale (or be really lucky, or better yet both). Venture capital has shortened the learning curve for some innovators, but bias has limited access to venture capital for many. Unconscious bias is like an odorless gasits imperceptible to most, but pervasive and deadly.

To optimize the innovation ecosystem, institutions must invest more in leveling the playing field. Today and for much of the documented past, innovation has been reserved for the children of middle- and upper-class parents. (Research the founders of companies valued at over $1 billion.) We laud the proverb Necessity is the mother of invention, but the people who grow up needing the most, independent of their intelligence, are often left out of the innovation game. As with all games, the best players emerge when the barriers to entry are low, the rules/standards are equally enforced, and there is high transparency across the board.

Audre Lorde once wrote: The masters tools will never dismantle the masters house.

I am a short, melanin-enriched, queer female on planet Earth. In some ways its easier to be innovative when youre invisible, but at some point, you need tools to scale: capital, team, mentorship. The one thing I know now that I wish I had known earlier is that my path toward getting the tools I need looks a lot different from the paths of others. Its not better nor worsesimply different. The hardest part is carving it out. Now that I know my path isnt blockedrather, it just didnt existIm way better equipped to win.

COURTESY PHOTO

Founded DotLab, which makes diagnostic tests focused on womens health.

About a decade ago I worked at the White House Office of Science and Technology Policy, whose goal was to speed up the commercialization of technologies being developed in federally funded labs. While there I saw that some of the most important work done by the government involved things the media paid no attention tofor example, the way it could use investments in research and development to fuel private--sector innovation.

In 2009, the Obama administration released the Strategy for American Innovation. The idea behind it was to establish the critical nature of federal government support for R&D. In particular it stressed the spillover effects, or the idea that investments in such research end up being beneficial to people unrelated to the original investment. Or to put it another way, R&D investment is a public good. Analyses at the time suggested that in order to produce economic growth we should be doubling or quadrupling our R&D investments. Instead that spending has since been slashed, especially in basic research.

President Obama also launched a Lab to Market Initiative meant to speed the path to market for technologies stemming from government--funded research. There were also pilot programs designed to increase the use of government-funded R&D facilities by entrepreneurs, create incentives to commercialization, and improve, among other things, the impact of the Small Business Innovation Research (SBIR) program.

My own company, DotLab, ended up being a beneficiary. We develop novel molecular diagnostic tests for prevalent yet underserved diseases affecting womens health. Its notoriously difficult for this field of early--stage diagnostics to attract private investment, because of unclear regulatory pathways, low reimbursement rates, or resistance to change among physiciansor all of the above. Many promising diagnostic technologies never make it to patients because its so hard for these types of companies to get financing. A grant from the SBIR was critical to our early success. I cant be sure that wed be here today without it.

COURTESY PHOTO

Founded Ubiquitous Energy, which makes transparent solar cells that can be put on windows or device screens.

I used to imagine innovators as individuals, as most people probably dothe genius inventor divining solutions in a lab or garage. But this picture that people have is not only wrong; it hinders our ability to innovate effectively.

Eight years ago I cofounded Ubiquitous Energy, a company based on an innovation Id helped to launch from an MIT laba transparent solar cell that promised new ways of deploying solar technology, like windows that generate energy or consumer devices powered by their own displays. I learned that in the messy, scrappy world of tech startups, the key to innovation is to make it a team sport.

Taking any innovation from the lab to commercial reality requires engaging with all sorts of people. You need to work with engineering, R&D, business development, and sales teams, as well as investors, advisors, and customers. By thoughtfully designing teams and carefully tending to the connections among them, you ensure that innovation doesnt happen in a vacuum. If you isolate the engineering team you risk creating an innovative technology that doesnt have a customer. If you listen only to the customer you might conceive of a product that cant practically be made. Neglect investors and you can find yourself with a business plan that nobody wants to fund.

Working among people with competing priorities takes more effort. It means encouraging communication so theyre aware of each others needs as they generate new ideas. You have to find a way to invite these ideas in, make it okay for people to disagree respectfully, and encourage the flow of ideas among the various groups. You need each person to focus on his or her task, but not so much that it creates boundaries and kills any sense of creativity in the group.

Ive found that viewing innovation as a team sport instills a creative culture that makes an organization better. The innovations that result are far greater than anything that might have come from any one person operating independently.

CHRIS SCIACCA / IBM RESEARCH

Founded Somalias first incubator and start-up accelerator; now at IBM Research.

People tend to think innovation can be neatly placed into two categories: incremental or disruptive. They also assume that the only category that really matters is the disruptive kind, where you dramatically transform markets or introduce a novel product. And yes, disruptive innovations in CRISPR, quantum computing, or batteries are undoubtedly worth the headlines.

But Ive learned that there is immense value in incremental innovation. When you improve an existing product to cut costs, or when you make that product more efficient or user friendly, thats what pays the bills. And in fact those little innovations can give you the needed tailwind to go after the disruptive ideas, which can take years to incubate and bring to fruition. Never underestimate the importance of incremental improvements.

TIM O'CONNELL

Cofounded Imprint Energy, which is developing thin, flexible, and safe print- able batteries.

As a CEO of a startup, you get used to hearing no. You also face an endless succession of what feel like earth--shattering crises, like nearly running out of cash, losing a key customer, discovering a widespread product failureor having to shut down operations because of a global pandemic. But it turns out that these disasters can actually be good for you. In fact, Im not sure you can innovate without them. Heres what all our crises have taught me.

Its good to be uncomfortable. We once had a key customer request a battery capability that wed never deployed before. The customer made it clear that if we couldnt develop this capability theyd be less confident in our product. We wrestled with the risks, not least of which was the potential embarrassment if we couldnt meet the customers needs. We knew wed face many technical problems with no obvious solutions if we tried to pull it off. Yet we decided to try to satisfy the customer, even if it wasnt obvious at first how we could get it done. A few weeks later we delivered something beyond what the customer had asked for, and weve since grown this capability into a powerful sales tool and potential revenue streamnot to mention it strengthened our relationship with the customer.

Short-term failure is good. A few years ago our company began to scale up our manufacturing output in response to a customers need. In the process we discovered aberrations we hadnt seen during smaller-scale production. Our team dived into failure analysis, and we finally attributed the problem to a single material within the battery. Wed used this material for years, but now we needed a replacement. Once we deployed that change, the battery quality, reliability, and manufacturability drastically improved.

Its okay to be vulnerable. One of my hardest days as Imprints CEO was the day I found out I was pregnant. We were in the middle of raising a funding round, we had begun scaling our manufacturing output, and I had been traveling nonstop for a year. Until that day, I had assumed that my role as CEO was to exude strength and confidence. With the mounting pressure I was harder on myself than I needed to be, and now I had the added stress of being pregnant. I decided to acknowledge to my team that I was overwhelmed. They rallied together and found ways to operate more efficiently and communicate more effectively, supporting me to focus my time and leverage on our most pressing goals. This gave me not only the space to plan for the companys future, but also the resiliency to prepare for my own new normal: leading while becoming a first-time mother.

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Six tales from the trenches of running a startup - MIT Technology Review