Male fruit flies’ decline in fertility with age is not only driven by changes in sperm – Mirage News

Infertility is one of the most striking effects of ageing. The impact of ageing on females fertility is more severe and much better understood, but it also affects males. Male reproductive ageing is less researched, but of those studies that do address it, most focus on sperm. However, ejaculate contains more than just sperm. Proteins in the seminal fluid are important for fertility, and in many animals, they have a dramatic effect on female physiology and behaviour. Little is currently known about the impact of male ageing on these proteins, and whether any changes contribute to poorer ejaculates in older males.

To resolve these questions, researchers at the University of Oxfords Department of Zoology conducted experiments in a model organism, the fruit fly, Drosophila melanogaster. This species typically lives for less than five weeks, which means that researchers can very rapidly measure the impact of age on male fertility, and their sperm and seminal fluid proteins. This species is also highly amenable to genetic studies, which allowed the researchers to genetically manipulate male lifespan, to see how this impacted the decline in fertility with age.

Published this week in PNAS are their results which show that both sperm and seminal fluid protein quality and quantity decline with male age, making distinct contributions to declining reproductive performance in older males. However, the relative impacts on sperm and seminal fluid often differ, leading to mismatches between ejaculate components. Despite these differences, experimental extension of male lifespan improved overall ejaculate performance in later life, suggesting that such interventions can delay both male reproductive ageing and death.

Lead author Dr Irem Sepil, from the University of Oxfords Department of Zoology, says: These results highlight that the decline in fertility with male age is not exclusively driven by changes in sperm. The quality and quantity of the seminal fluid proteins also change as males age, and these patterns can differ from the changes seen in sperm, but still impact male reproductive function. However, a manipulation aimed at increasing lifespan also slows down age-related reproductive decline. This means that it is possible that drugs and treatments aimed at promoting healthy ageing could be co-opted to slow down male reproductive ageing.

Going forward, the researchers want to look into the health of offspring. In humans, children of old fathers are more at risk of certain medical disorders, but the mechanisms driving these changes remain unclear. Also, whilst a lifespan-extending genetic manipulation helped fertility in older males, it is not clear whether less invasive treatments, which might be used in human medicine, would work similarly. There is ongoing research to understand how we can increase the healthspan of individuals. The aim is not to live longer but to age healthily, slowing down the onset of age-related diseases such as cancer, Alzheimers and arthritis.

It is important to note that the work described here was on a species of fly. While ageing mechanisms are often similar across animals, to understand whether the patterns are commonly shared, they will need to be examined in other species.

Read the paper in PNAS: https://www.pnas.org/content/early/2020/06/30/2009053117

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Male fruit flies' decline in fertility with age is not only driven by changes in sperm - Mirage News

Pirbright Institute: Pigs ideal for assessing flu antibody therapies – The Pig Site

They also demonstrated pigs are suitable for analysing the delivery systems used to administer the antibodies in order to provide longer lasting protection.

Having been successfully utilised for Ebola virus and respiratory syncytial virus, the use of antibodies to provide protection and reduce symptoms of influenza is an area of great interest. Although several influenza antibodies have progressed to clinical trials based on their success in small animals (ferrets and mice), the outcome has been disappointing as no antibodies have shown therapeutic effect in humans.

A previous study by Pirbright showed that pigs are good models for influenza vaccine studies as they are naturally infected by the same subtypes of influenza viruses as humans, have similar immune systems and are more comparable in size and physiology than smaller animals.

The teams new research, published in the Journal of Immunology established that a human antibody (2-12C) can neutralise the H1N1 2009 flu pandemic virus in pigs, thereby providing protection. Both the amount of virus and signs of infection in the lungs were reduced in pigs that received treatment.

Alongside testing the efficiency of 2-12C, the team also assessed a new antibody delivery method that works by administering the antibody genes to pigs. Once inside pig cells, the genes continuously generate antibodies, providing longer term protection than a single direct inoculation of antibodies. The team showed that this gene delivery method for 2-12C was able to protect pigs from signs of disease typically caused by H1N1.

The success of this antibody and delivery platform in the pig model indicates that these treatments could potentially also work in humans. The pig provides an excellent intermediate step between trials in smaller animals and humans and could provide more accurate assessments of antibody therapies against influenza.

Dr Elma Tchilian, Head of the Mucosal Immunology Group at Pirbright said: We are very excited that the pig model is becoming useful for testing and refining antibody treatments for life threatening influenza infections and could be equally useful for other infectious diseases.

This research was funded by the Bill & Melinda Gates Foundation, the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI) and the National Institute of Allergy and Infectious Diseases, part of the U.S. National Institutes of Health.

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Pirbright Institute: Pigs ideal for assessing flu antibody therapies - The Pig Site

Bringing smart science used to protect premiership footballers to the offshore market in the fight against Covid-19 – Bdaily

Tyneside-based marine engineering specialists, TSG Marine, is taking the latest molecular technology offshore to support the energy sector on its journey out of the Covid-19 crisis.

Utilising the same smart science used to protect premiership football players and staff in stadiums, TSG Marine has secured a deal to make the technology available to oil and gas, marine and renewable assets operating in the North Sea and beyond.

Energy companies have been particularly hard hit during the pandemic and ensuring offshore teams and their families are protected against the transmission of the Covid-19 virus is critical.

Going beyond disinfecting an environment, TSG Marine is deploying a rapid sanitisation system which not only renders a workplace virus-free but a molecular layer, when applied to surfaces, kills all viral, bacterial, mould and organisms for up to 30 days.

TSG Marines Protect+ is a process based on science, using the physiology of viruses, bacteria, mould and organisms against them.

When applied to a surface, ZOONO leaves behind a mono-molecular layer that bonds to the surface. These molecules form a barrier of positively charged microscopic spines that attract and pierce pathogens causing them to break up with lethal effect. This layer of molecular antimicrobial spines is laboratory tested to carry on working for up to 30 days on surfaces and isnt disrupted by regular cleaning practices.

TSG Marine, managing director, Erika Leadbeater, said: Were working with companies in the offshore energy sector as they plan their route out of the COVID-19 crisis. Its important we establish new ways of working that protect their teams and we believe this technology is the solution.

We work with our customers to design the most appropriate programme for their facilities to reduce risk, identifying high transmission areas, utilising fogging for maximum coverage and spray application for exterior locations. With training and supplies of top-up fluids for high contact areas, we will work with the infield personnel to educate and inform, keeping their environment safe. On completion, our technicians will issue a certificate of sanitation which customers can use to help reassure workers of their safety.

We are also bringing temperature monitoring equipment, as weve seen deployed in airports, to help the industry test workers joining facilities for signs of infection. This not only reduces the spread of the virus but ensures those workers showing signs of infection are not putting their own health at risk by travelling offshore.

This non-contact, fast screening process, utilises artificial intelligence to detect elevated temperatures in up to 30 people a second with an accuracy range of +/-0.5oC. Together with TSG Marines expertise in marine and offshore environments, this technology can be applied to make the offshore industry safer amidst a public health crisis that is challenging all companies to change the way they do things.

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Bringing smart science used to protect premiership footballers to the offshore market in the fight against Covid-19 - Bdaily

The anatomy of a rule-breaker’s mind – News – Khaleej Times

So much has been written about those who care to stay safe and go to great lengths to ensure minimum risk from the Covid-19 fallout. There are some who have literally barricaded themselves against the outside world and if that is what floats their boat so be it. Nothing wrong.

But not much is written on the mindset of those who seem to think the rules are not for them and they can cheerfully defy the advice or orders and do their own thing. This includes making a mash of social distancing at pools and on beaches, dropping the mask at every opportunity, getting together with friends surreptitiously and thinking they are achieving some medal of honour for outsmarting the system, taking chances because what the heck you only live once, so enough already, let's party. There are even those who jeopardise their kids by taking them along otherwise it ruins their fun.

It is pretty much the same mental reasoning (or lack of it) that stops people wearing a seatbelt or lets them drive rashly and under the influence. Psychiatrists says it is intrinsic to human nature to defy authority and it makes folks feel brave and heroic. It is a kind of high and "researchers from the University of Washington, Harvard University and other institutions found rule-breakers feel smarter and more capable along with being in an unexpectedly good mood after breaking a rule".

If freedom is a place where there is nothing left to do then that freedom finds expression in being a maverick. It works in the mind as a strike for the individuality, see I do not care, I am doing my own thing. There is something romantic about being the lone wolf, the class cheat, the free spirit. That it amounts to foolishness is swiftly ignored.

Another factor that drives the rule breaker is laziness. Such people cannot abide inconvenience to themselves and any rules that increase their effort line is met with resistance. Whatever the level of danger the discomfort of staying home is trumped by the need for self gratification. In much the same way many of us are afraid of being left out, left behind, left on the sidelines of life as we see it so we need to give presence even if goes against plain common sense.

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The anatomy of a rule-breaker's mind - News - Khaleej Times

Kanpur Bloodbath: Understanding the Anatomy of an ‘Encounter of the Police’ – The Wire

From what has appeared in the media, the death of eight Kanpur police officials in the line of duty is being projected as a simple trap or ambush into which an unsuspecting police party had walked in. That was apparently the third attempt that night to get to the notorious criminal, Vikas Dubey. However, a professional analysis of such an incident must not stop at that.

It must be kept in mind that the usual tendency of official departments is to avoid such analysis at all costs, brushing everything under the carpet of routinely made citations for medals. For example, the report of the one-man inquiry committee, headed by the former BSF chief E.N. Rammohan, into the naxal ambush on a CRPF party in Chintalnar, Chhattisgarh, on April 6, 2010 in which 76 personnel were killed, was never shown to CRPF field officers. How then can one expect any course correction from them?

Did darkness put the police to disadvantage?

It is claimed that streetlights were smashed and that the road was blocked with a JCB. The question is, so what? An argument that it was pitch dark and hence the police could not see the assailants is illogical because it was the thirteenth day of the bright half of the lunar cycle, the full moon coming on July 5. Moreover, there is no reason to suspect the assailants had night vision devices.

With the main beams of the headlights of their vehicles which are presumably on compliance with the Central Motor Vehicle Rules the police should have been able to see the JCB from a distance of 155 metres. This should have set alarm bells ringing and they should have got down immediately and taken defensive positions pending the arrival of reinforcements and protective equipment.

The JCB was parked some 50m away from Dubeys house. Had they stopped immediately upon seeing it from a distance and waited for reinforcements, their assailants would have found themselves at a considerable distance, making it very difficult for all but the most skilled shooters to take pot shots at them.

Also read: Police Demolish Mansion But Kanpur Gangsters Clout Was Built on Deep Political Connections

It is also reported that the police searchlights drew more fire. If that is correct, it is was an elementary mistake. In fact, remotely operated searchlights have been developed even by the DRDO precisely for such situations. The police department is answerable as to why such elementary things have not been procured.

Tactical mistakes in the operation

It has been reported that the police party started walking towards the gangsters house. If that is correct, walking in the open without any protection was a fatal mistake.

An earthmover vehicle is used to remove mangled remains of a car during the demolition of the residence of criminal Vikay Dubey, after an encounter in Bikaru village where 8 police personnel lost their lives, in Kanpur, Saturday, July 4, 2020. Photo: PTI

Media reports suggest that the police party did not have bullet resistant jackets or helmets. This is intriguing. If everybody knew that they were going to face a daredevil criminal, why did they not prepare accordingly? Were they under an impression, for whatever reason, that Dubey would give in meekly? The post-incident inquiry must examine this aspect also.

Regarding the death of the DySP Devendra Mishra, it is reported that he took shelter (or was dragged) in a house which unfortunately, turned out to belong to Dubeys maternal uncle, Prem Prakash Pandey, and was shot there in the head. One SI and one constable were also found dead there. Two were found outside the door; and one was found in the verandah of the same house. Five cops are said to have taken cover in a half-built toilet about 20 metres from the rear boundary of the house but that did not help them. Amar Ujala reports that the DySPs body was mutilated with a sharp-edged weapon, whereas the five bodies were piled onto each other.

It has also been reported that the Amar Dubey, nephew of Vikas Dubey, snatched some weapons of the police. In all, an AK-47, an INSAS rifle and two pistols were snatched.

If the DySP was dragged inside some house and if Amar Dubey snatched weapons, it would mean that multiple assailants were on the ground too and were not just firing from the safe sanctuary of rooftops.

Also watch | Kanpur Encounter: How 8 Policemen Were Shot in an Ambush by Vikas Dubeys Men

These accounts, if true, would indicate that there was either little controlled firing by the police party or that they had run out of ammunition by the time the assailants closed in. A post-incident inquiry must examine this.

As it happens in any ambush, those who had planned it must have ensured that, first, they themselves have adequate cover from return fire and concealment; and second, that possible covers, which the targets could take, are subjected to fire in such a manner that the cover is effectively neutralised.

The layout of the ambush must be carefully examined by investigators. It would also give an idea of the time taken in laying the ambush. That would, in turn, given an idea of when they would have got the information regarding the impending raid.

It appears that the police were first taken surprised by hostile fire and then outgunned, making return fire ineffective. In the end, it became an encounter of the police.

Was Information of the impending raid leaked?

That the information about an impending raid might have been leaked is extremely likely. Media sources cite the state DGP admitting this and an SHO ,Vinay Tiwari of Chaubepur PS, has been suspended.

However, that leakage alone was not responsible for the fatalities.

A much more glaring failure was that of the intelligence machinery. They had obviously no idea of the sort of weaponry which this criminal possessed. Given that kind of weaponry, even if the information were not leaked, the criminals could have still poured in deadly fire from inside Dubeys house and inflicted heavy casualties.

His house (demolished by the same JCB on July 4) is believed to have a dozen CCTV cameras. Taking him by complete surprise was not possible.

After all, the options before a police party supposedly going to arrest somebody are limited by law. They could neither bulldoze their way into his house (there was no bulldozer anyway, nor is it legal to do so), nor enter it surreptitiously. Knocking on the door was the only feasible option and that would have given him enough notice to position shooters and weapons before he answered the bell.

Intelligence lacking on weaponry

Much is being made of the alleged use of automatic weapons like the AK series rifles. That raises very serious questions. From where are they getting those rifles? Why could intelligence never make any headway on this issue? They have obviously no clue because if they had any idea, the next question would be why the source of supply was not disrupted.

Also read: Kanpur Gangster Assaulted, Humiliated Police Party Before Gunning Down 8 Policemen

Even before I entered service 34 years ago, we had been hearing that illegal firearms are manufactured in Munger (Bihar), Malda, Howrah (WB), parts of Jharkhand, Dharmpuri, Theni (TN), Mirzapur-Bardah (UP-Bihar), Daulatpur and Baisar (Bihar) and Bamhaur (Azamgarh, UP) etc. Now these places are neither in Antarctica nor, in the words of the opening voice-over of Star Trek, places Where no man has gone before.

What has prevented the police and the intelligence machinery of the states and Centre from identifying them, hunting them down and destroying them during all these decades? Do they mean to tell the people of the nation that these arms manufacturing units are run 100 feet deep underground and have such a secretive network of operatives that no one ever gets any wind of them?

It is either most despicable, rank incompetence or good, old corruption in the ranks of the police and the intelligence department. Odds are in favour of the latter.

Moreover, let no one give an outrageous theory that the AK series rifles could have been made in the bad lands of Munger etc. That would be a crass attempt to hide their incompetence. From an engineering perspective, it is simply not possible. There is no way one could make a complex thing like the bolt of an AK rifle or barrel, without possessing machines made specifically for the job and those machines are not made in India. Making a double barrel shot gun in craft production is one thing; making an automatic rifle quite another.

Uttar Pradesh Chief Minister Yogi Adityanath pays tribute to policemen who lost their lives in an encounter at Bikaru village, at Police Line in Kanpur, Friday, July 3, 2020. Photo: PTI

Making the parts of a modern rifle like the rotating bolt carrier etc. necessarily requires factories and sophisticated machines made specifically for that purpose. Rifling a barrel, for example, requires something called a rifle lathe. The lands and grooves in a typical rifling are cut and measured in a thousandth of an inch. You cannot make such parts with a file or drill in your hands. The bullet fits the rifling of the barrel to within one-thousandth of an inch. The tolerances being so small, this sort of accuracy can come only with sophisticated machines.

Making ammunition for the rifles is even more difficult as it is impossible to make the chemicals required in your backyard. The intelligence should have also known from where they get the ammunition because it is a consumable item; rifles procured once could last for years, but you need ammunition regularly.

Why did Dubey kill the police?

Normally, even hardened criminals avoid killing policemen for fear of obvious repercussions and reprisals. If Dubey did kill as many as eight of them, it obviously means that he might have sincerely believed that the police party had paid a visit not to arrest him but to eliminate him in an encounter. With the elaborate preparations that they made for the ambush, it appears that opening fire on the police was not an act of reckless bravado. He did it deliberately.

The point is, if he had been able to avoid jail all these years and had such clout that he got bail even in a case where he had killed Santosh Shukla, a politician of the rank of minister-of-state, inside Shivli police station and later got acquittal, why would he suddenly become so wary of getting arrested?

If he indeed believed so, it would follow that the culture of encounters that has been so assiduously built up by the UP police as a way of fighting crime can prove to be horrendously counter-productive.

Also read: A Chronicle of the Crime Fiction That is Adityanaths Encounter Raj

The media is now carrying stories how Dubey, in the past, had fired at a police team and taken a circle office captive; how he had slapped a DIG (Prisons); and how he had organised a gherao led by two MLAs of a police station when he was arrested, etc. The question is, when all this was known all these years, why did successive governments soft-pedal on him?

Talking of the political patronage enjoyed by Vikas Dubey is pointless now. If a criminal has survived comfortably in this field for so long, he must obviously have had the right connections at a thousand places, not just a few. Moreover, if he got bail and later acquittal in a murder case, he got it through the courts. Why was the matter not challenged until its logical end, that is, the Supreme Court? To mention political connections as the source of his bail automatically casts aspersions on the judiciary also. Are they prepared to level that allegation and face the consequences?

Lessons for the future

This incident raises serious questions about the preparedness of state police forces for combat in urban areas (as against combat in jungles), also variously known as FIBUA (fighting in built-up areas), UO (urban operations), MOUT (military operations in urban terrain) or by the archaic term CQB (close quarter battle).

The security forces in India habitually shy away from the intellectual exertion needed to master anything new and boast that the mere fact of donning the uniform entitles them to fight anytime, anywhere against anybody. Unfortunately, real life is different.

Indian security personnel do not have any institutional doctrine or detailed tactics, technique and procedures for urban or jungle combat. Whenever they have been obliged to operate in urban areas, they have fumbled and messed up. Their first exposure of urban combat was during Operation Blue Star at the Golden Temple complex in Amritsar in June 1984. They messed it up badly; eventually tanks had to be called in and the repercussions of the extensive collateral damage to the religious structures therein were heavy. One prime minister was assassinated and thousands of innocent people were killed in the communal massacres that immediately followed her assassination.

In almost all the operations that the Army/Rashtriya Rifles have been undertaking against terrorists in Kashmir, they end up blasting entire houses with explosive charges because the science of house intervention is not practiced the way the world does it. This habit of blasting houses has actually led to a great deal of alienation there. No one, not even a child, has ever believed in the pet theory touted for the benefit of ignoramuses that brick-cement houses van catch fire from bullets. It is a matter of simple physical chemistry that bullets cannot start fires or collapse houses.

In my opinion, officers and men of district police forces are mostly unsuitable for undergoing the rigours of the training in combat, both physically and mentally. Moreover, very few would be willing for this kind of thing, leaving the crores of rupees they could make in the districts. A practical solution would be to have a select band of at least a platoon each at the districts. These men must have volunteered for it and they can be especially trained. It is understood that special training infrastructure needs to be developed for both urban and jungle combat and suitable equipment procured. That is a matter of separate detail but can be provided.

Combat is a science that needs to be mastered with great effort. In this realm, the price of error, bravado or ignorance is indeed death.

Dr. N.C. Asthana, a retired IPS officer, has been DGP Kerala and a long-time ADG CRPF/BSF. Amongst his 46 books, he has also authored Ultimate Handbook of Urban Warfare.

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Kanpur Bloodbath: Understanding the Anatomy of an 'Encounter of the Police' - The Wire

Anatomy of a Try: Andy Muirhead vs Melbourne Rebels – Green and Gold Rugby

Anatomy of a Try: Andy Muirhead vs Melbourne Rebels

There is something about the set play and Australian Rugby, its in the DNA. Personally Im a big big fan of strike moves and in both the Australian games yesterday we saw two fantastic tries attacking the transition zone.

The Brumbies exploited the space at the tail of the lineout for Muirheads try and the Waratahs sent Maddock over for a cracker right through the gaping chasm left by the Reds.

That space is going to close up pretty quickly now its been exploited so openly but there was enough in both those tries to flag up there is plenty of detailed analysis going on, making these set plays hard to stop even when you know they are coming.

Lets have a look at Muirheads try, because despite the ridiculous ease in which it seemed to be scored, there is actually some cracking small-details work by the Brumbies that has a big part to play in stopping the Rebels shutting down something which should have been very stoppable.

Lets first of all look at how the Rebels are defending here.

Weve got Korobite defending at 2, makes sense as a big powerful hitter defending the narrow side.

Weve got Uelese defending in the halfback position. This is the norm, his job is going to be close off the attack around the tail of the line out and defend the punch through the middle of the line should the Brumbies pull a Red Sea and part it.

Sitting in behind both of them in the 11 position is Louwrens, and he is key and who the Brumbies actually exploit to create the try (stick with me this will make sense).

Then in defending at 10 we have Hardwick with Toomua defending in the 12 channel.

The Brumbies set is simple.

Swain and Douglas are both in the middle, so we know short of a front pop ball there are really likely only two areas of contest in this lineout the middle where they are both located and the tail with Samu. Cusacks not a jumping option on this occasion as hes in the half back position.

Its all simple stuff set up wise, but it is already causing the Rebels to think about whats happening. If it goes to Swain or Douglas then its likely to be a drive or a classic Brumbies fake and go.

If its Samu its probably going to be a pop down to Cusack coming around at pace.

Both are typical Brumbies moves weve seen many times.

They go to Douglas and its the catch and set which the Rebels have to defend pulling in the entire lineout.

Cusack lays the ball off to Faingaa who comes around to attack the tail where Uelese is waiting. At the same time Alaalatoa initiates the spin of the maul to take all the Rebels forwards away from the gap.

Uelese bites and Muirhead takes the inside ball to hare over.

via GIPHY

Simple stuff.

But lets look at the details around this move.

The first thing to note is Muirhead is only one of many options.

The Bumbies have set their midfield up very tight, Id question if they were actually 10 here but regardless as Faingaa comes around we see that Kuridrani is also an option and a good one that he can use and Lolesio starts to drift out as a back door option.

Watch as how Faingaa first comes around hes looking at Kuridrani, its an option and a good one, but with Hardwick and Uelese patrolling that seam its likely he sees they have Kuridrani marked and opts to change to the inside pass (hence hes not quite square enough to pass it comfortably).

This takes Hardwick out of the game, he has to hold his move for Kuridrani and to assist Uelese. Toomua obviously is going to watch for the slider option.

Thats creating the space for Muirhead to punch through.

But lets roll our thoughts back to Louwrens and question where did he go in all this? He was in the 11 position and in a perfect position to smash Muirhead.

Well, this is where Powell comes into play.

If we watch the far side as the ball is peeled we see Powell come flying around, its enough to make Korobite bite and its enough to pull Louwrens over initially before he realises whats happened.

If Powells run doesnt look overly convincing seeing as the ball was already with Faingaa, then just remember weve got all the luxury of a reverse elevated position.

At ground level all these guys are seeing is Powell come around the short side at pace whilst Faingaa is hidden by the set piece, ball or not thats enough movement to interest them and that is enough to create the opportunity to exploit.

Its easy to blame the Rebels defence here, call it poor but when you have a defender flooded with options as Hardwick and Uelese and Louwrens are here its going to cause indecision which is what the Brumbies exploit.

Bad defence, great attack, whichever way you sit this was a nice try to start the game with and a great score for Muirhead, its almost enough to forgive the hair do (almost).

Its easy looking at the Super Rugby Aotearoa games, to get caught up in their This is how Rugby should be played! brilliance and wonder, if everyone else is being left behind.

There is a fear that because teams are not playing the regular wider competition, theyll not keep pace with each other but from a different perspective maybe the enforced separation is a good thing?

Its giving everyone a chance to reset in their respective groupings, figure out what they are good at, at what theyre not and how they feel the game should be played and build accordingly. After all isnt the beauty of Union the fact there are so many ways to play the game and they all have their day?

As a first weekend out saw rejuvenated teams, with fresh players and there were two great games, after such a period out its as much as you can ask. Yeah both games were error strewn but this enforced isolation is, for the Australian teams, a great chance to bring through young kids in a tough inter-state scenario without getting taken to task by the New Zealanders, battered into mush by the South Africans all whilst dealing with the physical battering travelling to New Zealand and South Africa.

I think well see some really interesting development from the Australian teams, some exciting new players coming through and some new ways of attacking and innovating the attack.

This is, unless youre the Brumbies then its simply business as usual. Lord Lauries tank busters are going to steamroller you upfront before youve even caught your breath.

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Anatomy of a Try: Andy Muirhead vs Melbourne Rebels - Green and Gold Rugby

Giant Penguin-Like Birds May Have Once Waddled Around The Northern Hemisphere, Too – ScienceAlert

A new fossil discovery has revealed that New Zealand's ancient monster penguins were not the only human-sized, flightless birds waddling around our planet tens of millions of years ago.

Recent findings in North America and Japan suggest there were giant penguin-like creatures plodding across the Northern Hemisphere, too. And these birds may have been even bigger.

The strange thing is, the now-extinct group of birds, known as plotopterids, are not related to penguins at all - but theylook remarkably similar, and probably used their flipper-like wings in similar ways.

The earliest penguin ancestors first made their appearance a little more than 60 million years ago around what is today New Zealand. Plotopterids developed in the Northern Hemisphere much later than their southern counterparts, only appearing between 37 and 34 million years ago, and disappearing altogether 10 million years after that.

"These birds evolved in different hemispheres, millions of years apart, but from a distance you would be hard pressed to tell them apart," sayszoologist Paul Scofield, a curator at the Canterbury Museum.

"Plotopterids looked like penguins, they swam like penguins, they probably ate like penguins but they weren't penguins."

In a fascinating twist, this group of ancient flightless birds is more closely related to modern-day birds that fly just fine - boobies, gannets, and cormorants. In the past few years, we've come to understand a lot more about plotopterids, but this is the first time their anatomy has been compared in detail to ancient penguins.

Analysing the fossilised remains of 16 individual plopterids side by side with five representatives from three ancient penguin species, the researchers found many striking similarities along with a few sizable differences.

Both plotopterids and ancient penguins had long beaks embedded with slit-like nostrils, comparable chest and shoulder bones, and similar wings.But while some ancient penguins towered at 1.8 metres (6 feet), the largest plotopterids stood over 2 metres tall.

It's hard to imagine a bird, larger than a human, diving through the water, but it seems that was once a reality in both the Northern and Southern Hemisphere.

(Mayr/Senckenberg Research Institute)

Above:Artist's rendition of Kumimanu biceae, an extinct giant penguin, alongside a human diver.

Even though plotopterids have large webbed feet like penguins, the authors think they probably swam underwater relying mostly on their wings as flippers, judging by their anatomy.

"Wing-propelled diving is quite rare among birds; most swimming birds use their feet,"says ornithologist Gerald Mayr of the Senckenberg Research Institute and Natural History Museum in Frankfurt.

"We think both penguins and plotopterids had flying ancestors that would plunge from the air into the water in search of food. Over time these ancestor species got better at swimming and worse at flying."

The fact that this happened in distantly related organisms, millions of years apart and on opposite sides of the globe, is truly remarkable. It's a case of what scientists call 'convergent evolution', where similar traits develop in distinct species under similar environmental conditions.

Anatomical comparison of plotopterids and ancient giant penguins. (Mayr et al., Journal of Zoological Systems, 2020)

In this case, two separate groups of flightless birds developed the anatomy they would need to forage for food deeper and deeper underwater. It just turned out to be remarkably similar.

"We therefore hypothesise that plotopterids and penguins had ancestors which performed aerial plunges to submerse into the water and to reduce the energetic costs for reaching greater depths," the authors write.

We'll need more digging to find out why one lineage of these remarkable birds survived, while the other passed into oblivion.

The study was published in the Journal of Zoological Systematics and Evolutionary Research.

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Giant Penguin-Like Birds May Have Once Waddled Around The Northern Hemisphere, Too - ScienceAlert

Canon Medical at ECR: Bringing the Power of AI to Routine Imaging – MedicalExpo e-Magazine

Advanced intelligent Clear IQ Engine (AiCE) brings the power of AI to routine imaging. (Credit: Canon Medical)

Canon Medical will be showcasing some of its latest innovations at this years ECR Online Edition from July 15-19, such as the deep learning reconstruction technology Advanced intelligent Clear-IQ Engine (AiCE) or the Aquilion ONE/PRISM Editionspectral CT system.

The company, which is part of the Canon Inc group, offers a full range of medical imaging solutions. These include CT, MRI, ultrasound, diagnostic, eye care and interventional X-ray equipment, as well as a full suite of healthcare IT solutions that enable visualization and analysis of 2D, 3D, and 4D images of anatomy and physiological functions.

European Director Marketing Jack Hoogendoorn said:

What is most important for us is to focus on getting the best images possible and we address that at ECR. All our technologies are about getting the best images possible because that is what the specialists in the hospital wantthey need to be able to judge and diagnose based on what they see.

With more than 100 years experience in the medical industry, Canon Medical was known as Toshiba Medical Systems until 2016, when it was bought by Canon Inc. This, said Jack Hoogendoorn, is now resulting in some exciting developments:

We are seeing the technologies used in photo cameras and other imaging modalities from Canon Inc being combined with the medical technology we have. Based upon technology from Canon Inc, for example, is our Advanced intelligent Clear-IQ Engine (AiCE).

With Advanced intelligent Clear-IQ Engine (on the right) on the Vantage Orian 1.5T, it is possible to see through the noise to clearly visualize the anatomical structure of the hippocampus at high resolution while maintaining tissue contrast. (Credit: Canon Medical)

This deep learning reconstruction (DLR) technology, is now being integrated across a broad portfolio of scanners with a wide range of clinical applications. It features a deep learning neural network that can reduce noise and boost signal-to-noise ratio (SNR) to deliver sharp, clear and distinct images, further opening doors for advancements in CT and MR systems.Jack Hoogendoorn said:

It has exceptionally low noise properties and enhances anatomical resolution and reconstructs the image in real time until it gets the best image possible.

AiCE technology is incorporated in almost every CT system. Thus also within the Aquilion ONE/PRISM Edition, which will be introduced at ECR. This is a spectral CT system, which integrates AI technology to maximize conventional and spectral CT capabilities and automated workflows, while providing intelligent clinical insights to assist physicians in making more informed decisions across the patients care cycle:

It offers opportunity for innovation within medical imaging, said Hoogendoorn, having the power to illuminate clinical insights and initiate business opportunities designed to improve patient outcomes.Its innovative approach to CT reconstruction uses deep learning to distinguish true signal from noise to deliver sharp, clear and distinct images at fast speeds. Trained using vast amounts of high-quality image data, AiCE provides enhanced anatomical resolution across the whole body including brain, lung, cardiac and musculoskeletal scans.

The DLR technology provides pure energy datasets combined with full field of view acquisitions, patient-specific mA modulation (to reduce radiation doses) and whole-body coverage. The Aquilion ONE/PRISM Edition also has an all new CT fluoroscopy (CTF) interface enabling one-person operation thanks to ergonomically-designed controls and a versatile touchscreen tablet.

Finally, Canon Medical will also be showcasing its Compressed SPEEDER MR technology. MRI scan times are often a challenge in clinical practices, where shorter scan times are typically associated with lower resolution or decreased SNR. Hoogendoorn said:

Available on the Vantage Galan 3T and Vantage Vantage Orian 1.5T, the SPEEDER technology dramatically reduces MRI scan times. The technology provides exceptional image quality and has great potential to help clinicians improve productivity. Reduced scan times enhance patient comfort, which in turn produces higher quality images by mitigating patient movement caused by patient discomfort during long scans.

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Canon Medical at ECR: Bringing the Power of AI to Routine Imaging - MedicalExpo e-Magazine

Abdominal Aortic Aneurysm Repair Device Market Insights 2020 Industry Overview, Competitive Players & Forecast 2027 | Cook Medical Inc.,Endologix…

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‘Grey’s Anatomy’ Star Camilla Luddington Says She Would Love to Play This Character From Another Shondaland Drama – Showbiz Cheat Sheet

Greys Anatomy fans have been following the ups and downs of Dr. Jo Karev, played by Camilla Luddington. With her husband and longtime love Dr. Alex Karev (Justin Chambers) leaving her last season for former flame Izzie Stevens, Jos storyline for Season 17 may involve a new romance.

Luddington has become a fan favorite on the show since starting in 2012 and truly created a niche for herself on Greys. Yet the actress shared that theres another character from show creator Shonda Rhimes suite of dramas that she would love to portray.

Born outside of London, the Greys star revealed that a film classic inspired her love of acting.

I grew up in the UK and started training with the Italia Conti School of Dramatic Arts when I was just 11 years old, Luddington told the New York Film Academy in 2014. The movie The Wizard of Oz was what initially drew me to acting. At five years old I was able to understand that Judy Garland was an actress playing a character and that I wanted to do the very same thing.

Though Luddington has grown to love the United States, there are some things she longs for from across the pond.

RELATED: Greys Anatomys Camilla Luddington Pays Tribute To Her Late Mother on Instagram

I miss British humor. Its just different than American humor, the actress revealed. I get my fill by watching TV shows like The Office, Derek and The Inbetweeners.

Luddington is clearly thriving in her role on Greys and shares her gratitude on working with such a professional ensemble.

Every member of the cast has such a good work ethic. Its been great to watch their process for breaking down material and bringing life to it week after week, she explained. They are also so encouraging to new cast members which I think can be rare. They invite you to play in scenes and push you beyond your comfort zone.

Luddington revealed that her first scene with show star Ellen Pompeo, who portrays Dr. Meredith Grey, did not go according to plan since it was loaded with medical jargon.

I had a whole monologue of just medical dialogue that I had to say to Meredith without her saying anything to me and I was just legitimately terrible, Luddington recalled in a 2016 interview with BUILD. I was so nervous cuz I was such a fan of the show too I could not remember the lines.

Working with media mogul Rhimes has been a boost to the actresss career, where she looks to the producing powerhouse as a mentor.

Shonda has a way of keeping her audience on edge time and time again, Luddington raved. She doesnt give in to what the audience want And always ALWAYS it serves for a more captivating story line. Thats what I like about her. Shes just paving the way for females in the industry.

While shes happy in her role on Greys, the British star did admit theres another character she would jump at the chance to play.

RELATED: Why Greys Anatomys Camilla Luddington Says Her First Scene With Ellen Pompeo Was Legitimately Terrible

Scandals Olivia Pope. How could you not? she told Good Housekeeping in 2015. On top of being this fabulous, powerful woman, the outfits are just opening my trailer door every day and seeing those fabulous coats and hats would make each morning a little bit better.

Thankfully for Greys fans, Luddington never left her post at Grey Sloan Memorial!

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'Grey's Anatomy' Star Camilla Luddington Says She Would Love to Play This Character From Another Shondaland Drama - Showbiz Cheat Sheet