Stunningly Awful Web Overview Demos The Gruesome Anatomy of a Traditional 1-Hour Web Overview Demonstration And Some Solutions – Customer Think

In which we identify a number of common challenges with overview demos and offer solutions.

[Warning graphic and potentially painful content ahead!]

1-Hour Web Overview Demo Timeline

Heres the rough but strangely consistent timeline for most web-delivered 1 hour overview demos:

[Starting time for each element on the left side]:

00:00: Fumbling with Zoom/WebEx/GoToMeeting/Teams

Looks like John/Sue/Page/whoever is just joining now

Can you see my screen?

Looks like youre muted

Were hearing a really bad echo

(This consumption of time is delightfully known as the WebEx Tax).

00:04: Introductions, but generally one-sided

Introductions and brief personal history of each of the vendor participants, but limited information requested or offered regarding customer participants before diving in

00:06: Corporate overview presentation (gag), often including

1. Mission statement

2. Products and services (high level see next section at 00.18 for the gory details)

3. Product history and milestones

4. Founders and origins story

5. The Team

6. Revenue history and financials

7. Office locations

8. Obligatory logos slide(s) (with logos that often have nothing to do with this customers market)

9. Customer testimonials (actually the most useful part of corporate overview presentations, but often ignored by the vendor Why?)

00:18: Product overview presentation (yawn), including

1. Obligatory architecture slide(s), with equally obligatory rectangles and cylinders representing software and database components (how novel)

2. Equally obligatory product-centric slide (showing companys product in the center of a circle of other things (e.g., users, other applications, process steps, you name it so novel, once again!)

3. Key differentiators, presented without context to the customers needs or specific situation (and largely forgotten by the customer, since they havent yet seen a solution that makes remembering anything relevant)

4. Case studies, if any, that are typically skipped over because were short on time (too bad real case studies would be the most interesting section)

00:26: Actual demo, including

1. Slide that says, Demo (which lets the audience know that everything from this point forward is fake)

2. Opening statement that We planned on 45 minutes for the demo, but we only have 30 minutes remaining, so well have to go really fast

3. Followed immediately by, But wed like this be interactive, so please stop me if you have any questions (while the presenter is actually thinking, But please dont stop me because Ive got so much to cover and youll interrupt my flow!)

4. Brief introduction of the plan for a story and 5 fictional characters whose day in the life will be followed in the demo

5. Followed by a firehose-like delivery with the presenter speaking non-stop for 4, 6, or 8 minutes or longer (I just saw an overview demo where the presenter went on for 40 minutes non-stop!)

a) Interspersed with the obligatory, Any questions so far?

Customer response? Nope, were good

b) Or Does that make sense?

Customer response? Um, yes (What else could the customer say to that?)

6. Overview of navigation elements

7. Introduction and definitions of vendor jargon, acronyms and product names (e.g., What we call a _____)

8. Repeated comment that everything is configurable

9. Repeated comment that everything can drill-down to the underlying data

10. Details on how to set up the application, (even though this task is typically done only once, when first implemented, and often by the vendors implementation team)

11. A walk-through of the workflow (a run-through, in fact, since time is really getting short)

a) Exploration of as many if, or, and also options as possible

b) Frequent references to, Remember when I (that arent remembered by the audience)

c) Zippy-Mouse-Syndrome mouse movements exacerbated by a tiny mouse cursor that can barely be seen with the naked eye

d) Made even worse through the lack of use of annotation tools

e) Made yet worse by the vendor presenting from a high-resolution monitor to audience members laptops (I cant read the text)

12. The occasional piling on of a feature description by the salesperson, immediately after a perfectly adequate explanation by the presenter

13. Pre-answering questions that youve heard frequently (but werent asked)

14. Being driven into the weeds by a random question from a low-level customer team member

15. Cutting off customer questions before the customer finishes (because youve heard the question so many times before)

16. Not confirming that you actually answered the customers question, before moving on

17. A rapid verbal description of the canned and custom reporting and dashboard capabilities:

a) Often including the claim that we have over 600 canned reports/dashboards of which a typical user might only consume a few!

b) Discussion of broad report and dashboard editing and creation capabilities

c) Repeated comment that everything can drill-down to the underlying data

18. Showing data that is obviously fake and/or lacks problems to solve, opportunities to exploit, or exceptions to investigate

19. Comment that we didnt have enough time to show you everything

20. No summaries whatsoever just a firehose furiously flinging features, functions, and facts

21. No analogies or metaphors to improve memory retention for the audience

22. No stories to cement memories, either

23. And, of course, absolutely no communication of value

00:58 Salesperson summary, with marketing platitude value proposition statements (that have little or limited bearing on the customers specific situation)

00:60 Salesperson suggests scheduling a deep dive demo or offers a POC

Customer reaction of, Thanks well get back to you

Frightening, gruesome and remarkably common!

If the objective was to show the customer a demo then that objective was achieved but it is very doubtful that other tangible progress was made in the sale.

Very sad; and largely a waste of time for all involved.

Assessment Time Prepare Yourself!

Play a few recordings of your organizations overview demos and see how many of the items identified above you or your team does today. Score 1 point for each item committed above.

[If the recording shows that each item above was exhibited, then your score is (sadly) ~50 the good news is you have LOTS of room for improvement!]

Now for grading how did you do?

0-5 Points: A your demos are delightfully unusual (and you are likely a Great Demo! graduate!)

6-10 Points: B your demos could improve

11-15 Points: C your demos could really improve

16-20 Points: D your demos should seriously improve

20+ Points: F your demos qualify for membership in the Sales Prevention Team!

Sadly, most overview demos rate a C grade or worse. If you are comfortable with the results, read no further (and keep your expectations low!).

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Stunningly Awful Web Overview Demos The Gruesome Anatomy of a Traditional 1-Hour Web Overview Demonstration And Some Solutions - Customer Think

Grey’s Anatomy: 5 Times Callie Torres Was An Overrated Character (& 5 She Was Underrated) – Screen Rant

Over the last ten years, Grey's Anatomyhas seen a lot of significant departures from the show. While some of them had very dramatic and eventful exits, some were a little underwhelming and anti-climatic. One of these included Sara Ramrez, wholeft the show after a decade-long arc.

RELATED:Grey's Anatomy: 10 Facts About Callie Torres Many Fans Don't Know

Callie was one of the more memorable characters as fans saw her involved in someimportant and monumental storylines. She was a loyal and supportive friend, who would go to the ends of the earth to protect her loved ones. However, Callie wasn't perfect by any means. While some of her actions were underappreciated, there were also times where she had fans wanting to tear their hair out.

Despite Callie having all the qualities to make a great leader, she failed to step up when it mattered most. Her tenure as Chief Resident didn't last long after she failed to get the respect of her colleagues and made Bailey do most of her duties. When she proposed an unusual approach to operations, Callie needed her colleagues' reassurance to help her through.

Even when she got a seat on the hospital board, Callie wasn't as opinionated or vocal as the other members. Overall, she wasn't very good in pressured situations.

While Izzie and George's affair brought a lot of emotional pain (even for fans), the viewers shouldgive Callie more credit for the way she handled the situation. When most people find out their partners have had an affair, there tends to be a confrontation of some sort.

However, Callie handled the situation with maturity when she decided she wanted to talk things through. Even when Izzie humiliated her in the cafeteria, Callie took the moral high ground and walked away. How Callie managed to remain composed at this moment is anyone's guess...

While most fans believe Callie and Cristina had one of the most underrated friendships, now may be the time to really look at the flaws in the relationship. Despite Cristina being there for Callie in her time of need, the orthopedic surgeon never seemed to return the favor.

RELATED:Grey's Anatomy: 10 Reasons Why Cristina & Callie Aren't Real Friends

When Cristina was struggling with PTSD, Callie tried to pressure her into moving out. When Hunt humiliated Cristina in front of their friends, Callie didn't check in on her. Even when Owen and Cristina split up, Callie failed to show her support. Maybe this friendship is not as iconic as people believe them to be.

When fans rewatch the old episodes, did anyone else notice the special bond Callie and Meredith had? In Callie's final seasons, Meredith and the orthopedic surgeon grew closer as they bonded over their marital woes and children.

It first began when Callie stayed in Meredith's house after splitting with Arizona. While she was there, Callie helped Meredith with Bailey. When Derek and Meredith were struggling with long-distance, Callie took her out drinking and eased her fears. Callie even put her relationship with Penny on hold out of loyalty to Meredith. It's a shamethey never got more scenes before Callie left.

Season 12 saw Calzona fans' loyalty split down the middle as they battled for the custody of Sofia. While Callie has often be seen as one of the friendliest and most accommodating people, she was the complete opposite in this case. She was so cutthroat and ruthless especially when she allowed her lawyer to assassinate Arizona's character.

Not only did she degrade Arizona's social life but she also tried to make out her was a terrible mother. It's a bit ironic considering the case was brought about after Callie tried to move to another city for a woman she barely knew.

Fans have seen a lot of talented surgeons grace the halls of Grey-Sloan. However, only few get the recognition they deserve Callie being one. When it comes to Callie's surgical prowess, people tend to overlook her skills because she hasn't got accolades to her name. Yet, she too has been involved in some extraordinary and groundbreaking surgeries.

RELATED:Grey's Anatomy: Why Miranda & Callie Aren't Real Friends

Remember when she reconstructed Derek's hand by building cartilage from scratch? Or when she made Sunder Atluri walk again despite his polio making it near impossible. Let's also not forget how she made a man walk after experimenting with therapeutic hypothermia.

As evidenced by the partnership she had with Jo, Callie had the potential to be a good teacher if she put her mind to it. However, she was always seen to let herself down when she allowed her personal life to affect her professional judgment.

Remember when she neglected her Chief Resident duties because she was too concerned with Izzie and George? Or when she started treating Leah Murphy differently once she discovered the resident and Arizona had a fling. Let's not forget how she passed Webber's case onto an intern because she was still mad he didn't make her an attending.

When the writers first began exploring Callie's sexuality, the orthopedic surgeon was still in the midst of her journey of self-discovery. However, as the years progressed, the viewers had the pleasure of watching her turn into an LGTBQ+ icon as she became to embrace her bisexuality.

This was particularly resonant in the season 12 premiere, where Callie confronted a bigoted mother over her threats of her sending her daughter to a gay conversion camp. Considering how her parents struggled with her sexuality, it was good to see Callie become a vocal supporter and fight for those who had no one in their corner.

Over her ten years on the show, fans believed Callie was a loyal and attentive partner. However, her relationship with Penny showed she had a bit of a mean streak.

When Callie lost custody of Sofia, it appeared that the orthopedic surgeon blamed Penny. When the resident tried to console her, she shrugged her off and ended the relationship. All around the workplace,Callie treatedPenny coldly and dismissed her. It was a little unfair considering it could have been avoided if she had communicated with Arizona.

Over the course of the series, Callie and Arizona's relationship was tested as the couple faced many trials and tribulations. One of the biggest challenges they faced came in the aftermath of the plane crash, as it was revealed that Arizona had lost her leg. While many sympathized with Arizona's pain, not a lot of people recognize Callie's strength and struggles.

Although Callie wasn't on the plane, she suffered just as much as the "Grey Sloan Seven." She lost her best friend and the father of her child; she struggled with Arizona's recovery; she also had to look after Sofia while balancing her work life. Throughout it all, Callie proved how strong and compassionate she was.

NEXT:Grey's Anatomy: The 10 Best Couples, Ranked

Next Better Call Saul: 5 Reasons Lalo Is The Best Villain In The Breaking Bad Universe (& 5 Alternatives)

A writer, reader and tv fanatic, Kayleigh enjoys reading movie news and your film reviews. She has attained an Undergraduate degree in Creative Writing and is also the creator of the film and television blog 'The Critics' Corner'.

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Grey's Anatomy: 5 Times Callie Torres Was An Overrated Character (& 5 She Was Underrated) - Screen Rant

‘Grey’s Anatomy’ Star Camilla Luddington is a Britney Spears Lookalike in This Throwback Photo – Showbiz Cheat Sheet

Camilla Luddington of Greys Anatomy is awaiting the birth of her second child with husband Matthew Alan. Always active on social media, the British-born actress keeps her fans posted (pardon the pun!) on how shes spending quarantine with Alan and their 3-year-old daughter Hayden.

One follower of the Greys star recently came across a photo of Luddington that closely resembled a pop icon and decided to post it on Twitter.

Announcing her second pregnancy back in March via Instagram, Luddington communicates regularly with her fans on social media. While on lockdown amid the coronavirus crisis, the Greys actress described her daily routine while expecting a baby and keeping a toddler entertained.

Tired: Growing a human: Running around after another human: she postedon Instagram in April. Looking up baking recipes & never actually making anything: Wearing a bun for 72726 days:

The British star also confessed to feeling anxious during these unprecedented times and expressed her gratitude for her followers.

RELATED: Greys Anatomy Star Camilla Luddington Says She Would Love to Play This Character From Another Shondaland Drama

Keeping daily anxiety in check as best I can: Taking this s*it hour by hour: #saferathome: Luddington posted. thinking of you all and so much love to you and your families.

While Luddington posts plenty of fun pics and information, she also keeps it real when it comes to personal issues in her life. In March, the actress paid tribute to her late mother on social media, who passed away unexpectedly when Luddington was just 19 years old.

My mum died 17 years ago today,Luddington wrotein March on Instagram. I believe she visits me in my dreams whenever she is in them they are always so incredibly vivid and I always remember them in the morning. I miss her everyday but I know she is still with me.

The William & Kate star experienced many unresolved feelings about her mothers death after Haydens birth in April 2017. The past trauma began to cause anxiety for Luddington which prompted her to seek counseling.

RELATED: Greys Anatomy Star Camilla Luddington Posts Touching Mothers Day Photo With Daughter Hayden and a Tribute To Her Late Mom

When I had a child, a lot of my own trauma from losing my mom when I was younger kind of came up with me now being a parent to my own daughter, Luddington toldBustle. I started to get a lot of anxiety. I was constantly afraid that I was going to die early and leave her There was so much strength and, honestly, release in being able to go and seek out a therapist and speak about it to somebody,

With over 3 million followers on Instagram and 650K+ on Twitter, Luddington certainly has a strong fan base. One follower apparently stumbled across an old photo of the Greys star and remarked on the uncanny resemblance to a pop star.

I came across this photo & lmk how, just for a second, I thought this was Britney Spears, the fan captioned the pic of a blond Luddington. ps. I love u Camilla pls dont take it the wrong way haha.

The television doctor was clearly not offended in the slightest, confessing that she intended to replicate the Circus singer.

RELATED:Why Greys Anatomys Camilla Luddington Says Her First Scene With Ellen Pompeo Was Legitimately Terrible

I was 18 in this pic and trust me allllll I wanted was to be @britneyspears Luddington wrote in response.

Though the resemblance is striking, Luddington seems to be sticking with her brunette locks and Grey Sloan Memorial scrubs.

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'Grey's Anatomy' Star Camilla Luddington is a Britney Spears Lookalike in This Throwback Photo - Showbiz Cheat Sheet

The psychology and physiology of pain management in athletics – AW – Athletics Weekly

Gateshead International Athletics Stadium, July 31, 1983

With just one week to go before the inaugural World Championships in Helsinki, some of the sports top names are fine-tuning their preparations before jetting off to Finland.

As a bridging distance between 800m and 1500m, the mens 1000m has attracted an international field of half milers and milers. As they take the bell in a respectable 1:26.58, a familiar face on the European circuit is leading in his distinctive white vest and matching wristbands.

Down the back straight for the last time and BBC Grandstand commentator David Coleman is waxing lyrical about the virtues of the elegant striding American out in front. This being said, the man who will go on to record a lifetime best of 1:44.62 over two laps in Stockholm a year later is most certainly a specialist half miler and the rolling of his head as the 800m point fast approaches, signals an impending changing of the guard.

At that moment, Moscow Olympic 800m champion Steve Ovett predictably devastatingly kicks and opens up a gap on the field with Don Paige giving dogged, if eventually futile, chase over the final 200 metres. An unflustered Ovett stops the clock at 2:19.06, saving his customary wave to the crowd until after the finishing line on this occasion.

Further down the field, the battle for the minor places continues as 1976 Olympic 1500m champion John Walker edges past the long-time race leader, whose shoulders have by now joined his head in rotational motion and who will eventually finish in fifth place.

Thirty-seven years later, laughing as he recalls his capitulation over the final furlong, James Mays jokes: I was left looking like the coyote in an episode of Wile E. Coyote and the Road Runner! His lay citation to matters of the zoological continue as comparisons to a North American species of canine are soon superseded by reference to a mammal namely monkeys.

The man who achieved international recognition for his pacemaking work in the 1980s, which famously included guiding Steve Cram to a world mile record in Oslo in the summer of 1985, recalls: When I was running at Texas Tech, my team-mates coined the phrase Monkey City. I thought it was funny and a great description of how a runner feels when theyre in the final push of a race.

The thought of monkeys riding your back with the sound of eek, eek in your ear was quite amusing!

In his moment of jest, the three-time All American collegiate champion may well be speaking words of truth and offering us a few hidden gems in terms of both the psychology and physiology of pain management among athletes.

The sensation of pain occurs as a result of brain neuronal activity in the encephalon. The experience of pain is of course unpleasant but a necessity when one considers its vitality as a signalling function which enables us to ultimately avoid death and maintain homeostasis in biological terms.

The functionality of pain is that it serves as an adaptive function, allowing us as athletes to know when we have encountered our optimal load, be it in the realms of running, jumping or throwing. In disaggregating the notion of pain, Domzal (1996) spoke about three facets in terms of the somatic (sensual feeling), the cognitive (psychological) and emotional (which is the value judgement we place on pain). This is compatible with the work of Azevedo and Samulski (2003), who noted that while athletes seem to have pain thresholds similar to non-athletes, critically their tolerance to pain may well be higher. So in essence, its not what we experience biologically, but how we perceive that experience psychologically.

Pain is subjective and relative which is why the man who now teaches both at school and university level in his native Dallas continues: Of course there are times when you dont feel like youre attacked by monkeys, but actual gorillas!

What Mays might be referring to would be classified by the likes of Haythornwaite et al (1998) as a specific form of coping strategy for pain management. Rather than ignoring Monkey City, Mays recollections of that Gateshead race challenge us as to whether we should adopt a strategy of Mindfulness based upon acceptance that as endurance-based athletes, at some point in our races we will inevitably feel as if we live in such a frightening urban metropolis. This again has some support from the sports psychology literature in that Salwin and Zajac (2016) perceptively point out: Knowing when to expect the difficulties makes it easier for the competitor to prepare and overcome them This means that an athlete can, to a certain degree, prepare for pain.

So rather than running away from pain, we should actually be prepared to hug and embrace it.

While psychologically it clearly helped an athlete like Mays to objectify and externalise his pain as a monkey, references to Monkey City were shared among his collegiate athlete community. This means they must be understood at the sociological level because shared humour is subcultural and its learned behaviour.

This is no surprise in that pain is central to our sport. The ability to joke about pain is functional for us athletes and there is of course a plethora of literature around how humour can keep us well both psychologically and biologically (See Hassed, 2001). Humour is a necessity, not during a race but certainly when embarking upon the slog of training its a defence mechanism against quitting.

While psychologically accepting that one will encounter pain, elite level performers like Mays will always attempt to develop physiological strategies to try and deal with the build-up of acid in their blood which is one of the biological drivers of the psychological experience of inhabiting Monkey City.

In recent years, the esteemed Oregon-based coach Peter Thompson (see http://www.newintervaltraining.com) has done much good work to further the understanding of what exercise physiologists would term acidosis. When lactic acid is formed it dissociates into lactate and acid, the latter of which is formed of hydrogen ions. At the point at which the production of hydrogen ion exceeds the bodys ability to buffer and clear because the kidneys and lungs cant keep the systems pH in balance, acidosis is said to occur and thus athletes enter the gateways of Monkey City.

At the appropriate point of the periodisation cycle, intense training simply has to be performed in order to both physically and psychologically prepare both body and mind to cope with the accumulation of high amounts of hydrogen ions, which may be perceived as Monkey City in experiential terms.

In previous decades, coach education discourses have incorrectly termed this as lactate tolerance training. The aforementioned Thompson perceptively points out that a more useful term is in fact acidosis tolerance training because lactate itself can be functional for the body.

So how did Mays prepare in terms of the specificity of his own acidosis tolerance training for his visit to Monkey City?

The workout that I did which best prepared me to negotiate Monkey City was a 600m speed endurance, he says. I would run to the 600m mark and then jog 150m through the curve, turn around and jog back to the 200m start. At that point I would blast the final 200m.

I would do three sets of those and at the end I was totally exhausted but it simulated in the 800m and I felt it prepared me to compete at a higher level.

The work of the late national coach for middle-distance, Dave Sunderland (2005), would frame this as an event specific session. The three golden rules of this mode of session are (1) that each set always adds up to the target race distance; (2) that work is grouped into sets in order to allow sufficient recovery to undertaken work which challenges the lactate energy system; and (3) that second and/or third set repetition lengths tend to be shorter the than first set.

So it should be noted that Mays practice of this type of session included a differential element in terms of pacing namely that the 200m effort would be effected at a greater average pace than that over 600m. Additionally, unlike the doctrine offered by Sunderland (2005), he has undertaken sets of the same length of repetitions. So while Mays has deviated from a textbook way of undertaking event specific repetitions, he has done so in a way which serves his own individual developmental needs while remaining faithful to the underlying ethos or spirit of this mode of session.

So while Mays was a world-class 800m runner, lets take Sunderlands example of a world-class 1500m runner aiming to hypothetically run 3:30 first set = 500m (70s); 1 min recovery; 700m (98s); 30 sec recovery; 300m (42s) 15-20 min recovery. Second set = 5x300m (42s) 1 min recovery between repetitions.

The strengths of using the kind of event specific repetitions utilised by the man who was a regular for Team USA in the 1980s, along with the likes of Johnny Gray and Earl Jones, are that they are invaluable preparation for ones visit to Monkey City. The cautionary note is that this mode of session tends to be effected in the competition phase of the periodisation cycle only. This mode of session cannot be performed consistency over several months due to the considerable demands on the lactate energy system and excessive use will risk the kind of fatigue which can lead to both subsequent loss of form and potential injury.

The moral of the story is if you want to deal with the monkey on your back it is well worth having a natter to the man affectionately known as The Rabbit!

Questions for self-reflection

Matt Long is a former winner of the British Milers Club Horwill Award for Coach Education and the author of more than 250 coaching articles.He can be contacted at [emailprotected] for advice on this piece

For more on the latest athletics news, athletics events coverage and athletics updates, check out theAW homepageand our social media channels onTwitter,FacebookandInstagram

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The psychology and physiology of pain management in athletics - AW - Athletics Weekly

U of A ranked among world’s top energy research universities – Folio – University of Alberta

The University of Alberta is among the worlds best, if not the best, energy research universities according to an updated version of the QS World University Rankings by Subject, which also placed the U of A in the top 10 of sport-related subjects for the fourth year in a row.

The amended 2020 version of the subject rankings saw the U of A land in the top 50 in three new energy-related categoriespetroleum engineering (eighth), geophysics (46th) and geology (50th)to go with a previous 11th-place ranking in mining and minerals.

Clayton Deutsch, director of the U of As School of Mining and Petroleum Engineering, said part of the programs success is the impact alumni are having on the mining industry.

You go around to different mining schools around the world, there will be U of A alumni there, said Deutsch. In mining companies all over the world, there are always U of A alumni around there.

He also said the programs approach of being committed academically while remaining practical is what places the U of As mining education among the worlds best.

Even despite some economic woes in the province, we have essentially 100 per cent employment of our students graduating within six months of finishing, said Deutsch. We do that by remaining current and steadfast in our focus on solving real-world mining problems.

One of the enduring legacies of Kerry Mummery, outgoing dean of the Faculty of Kinesiology, Sport, and Recreation, will be the university ranked in the top 10 in the category of sport-related fields in each of the final four years of his tenure, up to seventh from ninth this year.

"During my tenure as dean, I've had the pleasure of working with and bringing in some of the top professors in their field," said Mummery. "I've always been impressed with the quality of their work and how that work makes its way into the classroom to provide our students with a solid foundation of knowledge they wouldn't have found anywhere else."

In the original rankings published in March, other U of A subjects that made the top 50 included nursing, which fought its way back into the top 20 to land at 18th; earth and marine sciences, which rose from 44th to tie for 41st; education, which rebounded from 47th to stick at 44th; and anatomy and physiology, which ranked 44th.

James Young, professor and chair of the U of As Department of Physiology, said he pins the U of As excellence in physiology to strategic recruitment pushes over the past four decades.

We've had sustained recruitment of really excellent young faculty members who want to be part of an excellent environment, and we offer that, said Young. They're not just joining the Department of Physiology, they're joining the faculty and becoming part of a number of research institutes and facilities that really are world class.

Overall, the U of A ranked in the top 100 in 17 subjects and 38 in the top 250. No ranked subject had the U of A lower than ninth nationally, and the university was ranked top five in Canada in 21 categories.

As for the five broad subject ranks, the U of A moved up seven spots to 90th in life sciences and medicine, while dipping slightly in engineering and technology (down to 112 from 107), natural sciences (111 to 116) and arts and humanities (137 to 143). Social sciences and management surged 12 spots to finish at 160.

The methodology for compiling each subject ranking can vary greatly and depends on the publishing rates in each area. Academic reputation, which accounts for anywhere from 30 to 90 per cent of the weight given in determining the rank in a subject area, draws on responses from thousands of academics worldwide.

Other measures include employer reputation, which makes up between 10 and 30 per cent of the measure; citations per paper, which also accounts for between 10 and 30 per cent; and h-indexa way of measuring both the productivity and impact of an academic's published workwhich is valued anywhere from 10 to 30 per cent.

The success in this latest QS ranking follows news in October that the U of A moved back into the top five in Maclean's 2020 Canadian University Rankings, thanks in part to strong showings by the faculties of nursing, business and science.

In August, the ShanghaiRanking Consultancys 2019 Academic Ranking of World Universities by Subject saw the U of A jump into an eighth-place tie with Princeton in the category of environmental science and engineering. Overall, the U of A finished among the top 100 in 21 of the 54 subjects assessed for the ranking, one more than the previous year, with eight subjects ranking in the top 50.

Earlier, the 2019 NTU Ranking of research output placed the U of A 81st in the world, up seven spots over the prior year. The advancement was bolstered by the university's 43rd-place performance in the subject of agricultural science, 47th in environment/ecology and 48th in electrical engineering.

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U of A ranked among world's top energy research universities - Folio - University of Alberta

Does Diet And Gut Bacteria Contribute To Arteries Aging? – Anti Aging News

Recent research from University of Colorado Boulder researchers published in the American Heart Association journal Hypertension suggests that a compound produced in the gut when we eat red meat damages our arteries, and it may play a role in boosting the risk of developing heart disease as we get older.

The report also suggests that an individual may be able to prevent or even reverse this age related decline by making some simple dietary changes and implementing targeted therapies such as nutritional supplements.

Our work shows for the first time that not only is this compound directly impairing artery function, it may also help explain the damage to the cardiovascular system that naturally occurs with age, said first author Vienna Brunt, a postdoctoral researcher in the Department of Integrative Physiology.

When a person eats a portion of steak or a plate of scrambled eggs the resident gut bacteria immediate set to work at breaking it down, as they metabolize the amino acids L-carnitine and choline they churn out trimethylamine metabolic byproducts which the liver then converts into trimethylamine-N-Oxide, known as TMAO, and sends it coursing through the bloodstream.

Studies have shown that those with higher blood levels of TMAO are more than twice as likely to experience a heart attack or stroke, and those with higher blood levels of TMAO also tend to die earlier. However, scientists dont fully understand why.

This team set out to answer three questions drawing on both animal and human experiments: Does TMAO somehow damage the vascular system? If it does damage the vascular system how? And is it one of the reasons why cardiovascular health declines, even among those who dont smoke and exercise as they get older?

Blood and arterial health of 101 older adults and 22 young adults were measured, which revealed that TMAO levels significantly increase with age. This finding supports a previous mouse study showing the gut microbiome changes with age, breeding more bacteria that help to produce TMAO. Adults with higher levels of TMAO were found to have significantly worse artery function and showed greater signs of oxidative stress or tissue damage in the lining of their blood vessels.

When TMAO was fed directly to young mice their blood vessels aged rapidly. Just putting it in their diet made them look like old mice, said Brunt. She noted that 12-month-old mice (the equivalent of humans about 35 years old) looked more like 27-month-old mice (age 80 in people) after eating TMAO for several months.

Preliminary data suggest that mice with higher levels of TMAO also exhibit decreases in learning and memory, indicating that it may play a role in age related cognitive decline.

Older mice that ate dimethyl butanol were observed to experience their vascular dysfunction reverse; the team believes that this compound may prevent the production of TMAO. Dimethyl butanol can be found in olive oil, vinegar, and red wine in trace amounts.

The team notes that even a young vegan will produce some TMAO, but over time consuming a lot of animal products may take a toll on vascular health. The more red meat you eat, the more you are feeding those bacteria that produce it, said Brunt.

According to senior author Doug Seals who is the director of the Integrative Physiology of Aging Laboratory this study is an important breakthrough as it sheds new light in why the arteries erode with age, even within the seemingly healthiest of people.

Aging is the single greatest risk factor for cardiovascular disease, primarily as a result of oxidative stress to our arteries, said Seals. But what causes oxidative stress to develop in our arteries as we age? That has been the big unknown. This study identifies what could be a very important driver.

The team is further exploring possible compounds that may block the production of TMAO to prevent age related vascular decline. Until something is found perhaps it may be a good idea to skip that big steak or at least limit the intake of animal products to incorporate more plant based options, as the gut friendly plant based diet can help to reduce levels of TMAO as well.

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Does Diet And Gut Bacteria Contribute To Arteries Aging? - Anti Aging News

A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily – Science

Kinase regulation conserved under stress

Oxidative stress is necessary for normal cellular function and tissue physiology but can also be pathological, and its effects are mediated in part through functional modification of various proteins. Shrestha et al. and Byrne et al. found that the oxidation of kinases at active siteadjacent cysteine residues, which were conserved across the eukaryotic kinome, regulated cell metabolism and mitosis. Shrestha et al. found that conserved cysteine residues within the diabetes-associated metabolic kinase FN3K acted as a toggle switch upon oxidation, promoting its functional oligomerization and consequently altering cellular redox status. Byrne et al. found that oxidation of mitotic kinases in human cells and yeast suppressed kinase catalytic activity and, in yeast, impaired cellular division. Exploring the effect of chronic oxidative stress on kinase function and how that may be spatiotemporally regulated may enable the development of new targeted therapeutics.

Aberrant regulation of metabolic kinases by altered redox homeostasis substantially contributes to aging and various diseases, such as diabetes. We found that the catalytic activity of a conserved family of fructosamine-3-kinases (FN3Ks), which are evolutionarily related to eukaryotic protein kinases, is regulated by redox-sensitive cysteine residues in the kinase domain. The crystal structure of the FN3K homolog from Arabidopsis thaliana revealed that it forms an unexpected strand-exchange dimer in which the ATP-binding P-loop and adjoining strands are swapped between two chains in the dimer. This dimeric configuration is characterized by strained interchain disulfide bonds that stabilize the P-loop in an extended conformation. Mutational analysis and solution studies confirmed that the strained disulfides function as redox switches to reversibly regulate the activity and dimerization of FN3K. Human FN3K, which contains an equivalent P-loop Cys, was also redox sensitive, whereas ancestral bacterial FN3K homologs, which lack a P-loop Cys, were not. Furthermore, CRISPR-mediated knockout of FN3K in human liver cancer cells altered the abundance of redox metabolites, including an increase in glutathione. We propose that redox regulation evolved in FN3K homologs in response to changing cellular redox conditions. Our findings provide insights into the origin and evolution of redox regulation in the protein kinase superfamily and may open new avenues for targeting human FN3K in diabetic complications.

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A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily - Science

Navigating cytokine storms – Penn: Office of University Communications

How do you define cytokine storm and sepsis?

Hunter: The last time I had the flu, about 20 years ago, I had a fever, I felt like my bones were being crushed, and I thought I was going to die. That was not because the virus was replicating in my lungs and causing a huge amount of damage; it was that these soluble immune factors everywhere through my bodythese cytokineswere causing this whole-body shutdown and making everything feel terrible. Thats how people think about cytokine storms.

Everyone has cytokines circulating in their bodies; thats a normal part of the immune response. But when that response overshoots where it should be to clear an infection, thats where it becomes pathological and is considered a storm. And it doesnt have to be an infection that triggers it. It could be that something turns on a T cell by mistake, it could be an autoimmune response, or it could be a treatment that boosts the immune response to cure cancer.

Mangalmurti: Sepsis is now defined as an abnormal host response to a pathogen, whether its bacteria, virus, parasite, or fungi. Most people should be able to clear the pathogen and return to a normal state. Sepsis is a dysregulated response where there is not necessarily a return to normal. In sepsis, the response is often characterized by both a hyperinflammatory and an immunosuppressive response happening at the same time.

Hunter: A cytokine storm can be part of that. The question is, At what point does cytokine activation become pathological? Immunologists may talk about cytokine storms, but Im not sure we really understand why they make our muscles ache or cause a fever or respiratory distress or heart failure. Thats one of the things were trying to explain. Why does it feel like this? How does it amplify? Why do some people make an appropriate response to control infection and live while some overshoot and die?

A through-line of this work seems to be that the immune response isnt always either completely protective or completely harmful, but it can be somewhere in between?

Hunter: Yes, its all about balance. Of course, we know that an immune response can be protective, but there are also immune-mediated diseases. Everyone knows someone with an immune-mediated condition like arthritis, lupus, diabetes, and inflammatory bowel disease.

How have the two of you been working together?

Hunter: When Nilam and I first met I quickly realized my interests coincided with hers. I do basic immunology studying mice, while Nilams science is informed by her time in the ICU. Ive enjoyed getting her perspective on how disease works and the model infectious system that my laboratory uses. When Immunity asked us to write a primer for people who didnt really know what a cytokine storm was, we took that opportunity and ran with it.

Mangalmurti: A pandemic is never a good thing, but it has been a learning opportunity for all of us and a chance to bring together bench-based scientists with physicians and physician-scientists. We have a huge number of sepsis researchers on campus that dont necessary think theyre studying sepsis or dont contextualize their work that way.

A group of physicians and immunologists, including Chris and myself, started a joint sepsis working group so we could bring together scientists from many walks of life, so anyone from clinical epidemiology to fundamental basic scientists. The first meeting we had there were so many ideas flying back and forth about sepsis and pathogens and host response. It was exciting to see people from PSOM, the Childrens Hospital of Philadelphia, and Penn Vet so engaged.

Now with the pandemic, a focus on understanding the host response to infection is amplified and relevant to questions like why some people with COVID have no symptoms while others get hit really hard.

How is what were seeing with COVID-19 confirming or changing what we understand about cytokine storms and how to address them in patients?

Mangalmurti: Part of why I wanted to do this primer was to sort through this amazing amount of information about COVID that has been pouring in from Twitter, bioRxiv, and medRxiv and other places and try to make sense of it.

There was an opinion piece in the Lancet early on in the pandemic that everyone latched onto that suggested that specific therapies to tamp down cytokine storms were going to be beneficial for COVID. It was early in the pandemic, and this idea seemed to make sense. But we dont have rigorous evidence to back that up and, as we have learned more, we realized that it is not so simple.

In sepsis, multiple therapies to bock cytokine have been tried before, and there hasnt been any survival benefit. In fact, there has been some increased mortality, maybe because the drugs are not striking the right balance of immune response versus immune suppression or are not being used at the right time point in the infection.

One thing that was very clear to us after the first week of seeing COVID-19 patients was that most who came into the ICU with organ failure clearly had a condition that seemed to predispose them to vascular injury: obesity, diabetes, high blood pressure, age, a history of vascular disease, or clots. And that was striking because its not something we usually see in most other forms of sepsis, or other forms of acute respiratory distress syndrome.

That got us thinking about innate immunity in the vascular compartment and whether this virus had a penchant for the vasculature. Maybe theres a way to use what we know about this relationship with the vasculature to design and use more targeted anticytokine therapies.

Of course, when patients are doing poorly, clinicians are often desperate for a treatment. I understand that; we just need to remember to proceed with caution when were treating with drugs outside of a controlled trial.

Hunter: From my perspective its exciting to think about targeted therapies that are already available, like antibodies to cytokines that are already used in the clinic; maybe they could be repurposed and used in this setting. But we really need large clinical trials to assess whether our excitement about some of these approaches is meaningful and valid. Perhaps one consequence of the pandemic is that more people will be thinking about how to more effectively use cytokine therapies or cytokine neutralizing approaches, not just in COVID-19 but in sepsis in general. Sepsis is a disease where the advances in immunology have not yet had the same impact that they have in other conditions, such as cancer and autoimmunity.

Can the idea of a cytokine storm help explain the spectrum of responses weve seen to the coronavirus, from asymptomatic patients to those with severe disease?

Mangalmurti: There are certainly anecdotes from people who get this disease that they are home, theyre having fevers every night, they dont feel well. These people are having a cytokine storm, but it resolves, and they dont end up on a ventilator in the ICU. Maybe those patients dont have the predisposing factors that we talked about. It could also be that they have less of a viral load.

Hunter: No one is studying the asymptomatic patients. One question is, How asymptomatic are they really? Maybe they had a small fever one day; maybe that was their cytokine shower.Also, as Nilam mentioned, in every other system the amount of the virus you are exposed to matters, so Im not sure why it wouldnt matter here, too.

You wrote this primer hoping to reach an audience of immunologists. What do you hope they start doing or doing more of?

Hunter: We, the basic immunologists, need to be thinking more about the physiology of what were doing. Often, well look at immune cells in isolation. We need to look at their effects on the vascular system, the impact on lung function, the impact on heart function. In general, we need to realize that it is really important to understand a whole disease process, to look at the system more broadly.

Your work seems to underscore the value of collaboration across fields.

Hunter: Absolutely. Nilam has worked on sepsis and has been seeing sepsis patients for a long time. Shes dealing with really sick patients who have a lot going on. Basic scientists tend to want to simplify and reduce things. And youve got to meet somewhere in the middle, I think, for complex diseases. Penn is a really good place to do that, at PSOM, CHOP, and Penn Vet.

Mangalmurti: Im usually talking with clinicians about ARDS and sepsis, and now to partner with immunologists who are taking a deep dive into the cytokines, into the pathobiology of these things and looking more at the host-pathogen interface, its a really nice intersection. As awful as the pandemic has been, I hope some of our trainees will be intrigued by all these unanswered questions and want to learn more about disease processes.

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Navigating cytokine storms - Penn: Office of University Communications

Humanigen Appoints Senior Executives to Management Team – BioSpace

BURLINGAME, Calif.--(BUSINESS WIRE)-- Humanigen, Inc., (HGEN) (Humanigen), a clinical stage biopharmaceutical company focused on preventing and treating cytokine release syndrome (CRS) with lenzilumab, the companys proprietary Humaneered anti-human granulocyte macrophage-colony stimulating factor (GM-CSF) monoclonal antibody, announced that several executives have been appointed to key positions at Humanigen.

Effective immediately, Dale Chappell, MD, MBA, has joined Humanigen to serve as its Chief Scientific Officer, David L. Tousley, CPA, MBA, has joined the company as Chief Accounting and Administrative Officer, Corporate Secretary and Treasurer, and Omar Ahmed, PharmD, has been promoted to the position of Senior Vice President, Clinical, Medical and Scientific Affairs. All three positions report to Cameron Durrant, MD, MBA, Chief Executive Officer, Humanigen.

Dr. Chappell began his career as a Howard Hughes Medical Institute fellow at the National Cancer Institute where he studied tumor immunology and published in the field of T-cell therapy, immunology pathways, and GM-CSF, giving him clear insights into the development and execution of our business strategy. He is also the founder of Black Horse Capital with decades of biotechnology investment experience.

Mr. Tousley has held roles including Executive Vice President and Chief Financial Officer and President and Chief Operating Officer at companies including Pasteur Merieux Connaught (now Sanofi Pasteur), AVAX Technologies, Inc. and DARA BioSciences. Mr. Tousley has led functions including finance and accounting, procurement, customer account management, strategic and financial planning and management, corporate governance, equity capital financing and business development, and raised in excess of $400 million in equity and debt financings in his career.

Dr. Ahmed has over 20 years of executive leadership experience building industry-leading specialty care portfolios, establishing strategic partnerships, and launching transformational blockbuster therapies. Dr. Ahmed held responsibilities for advancing Janssens $10 billion global immunology portfolio, from early development to late-stage development, including lifecycle management for Remicade, Simponi and Stelara and served as a board member for the Janssen EMEA Emerging Markets, covering 42 countries in the Middle East, West Asia and Africa Region. He also held leadership positons at Novartis and at Roche Pharmaceuticals.

We are pleased that both Dr. Chappell and Mr. Tousley, who have previously operated in interim capacities with the Company, have joined us as full-time members of the Humanigen team, stated Dr. Cameron Durrant. Their appointments, along with Dr. Ahmeds promotion, provide us with continuity and ongoing scientific and operational bench strength as we move the company forward. Filling these key leadership roles with proven executives who are highly regarded within the biotechnology sector, and who have been deeply involved with the strategic direction of our company, is a next step in our plan to rapidly grow into an organization committed to bringing important therapies to patients around the globe, Dr. Durrant concluded.

About Humanigen, Inc.

Humanigen, Inc. is developing its portfolio of clinical and pre-clinical therapies for the treatment of cancers and infectious diseases via its novel, cutting-edge GM-CSF neutralization and gene-knockout platforms. We believe that our GM-CSF neutralization and gene-editing platform technologies have the potential to reduce the inflammatory cascade associated with coronavirus infection. The companys immediate focus is to prevent or minimize the cytokine release syndrome that precedes severe lung dysfunction and ARDS in serious cases of SARS-CoV-2 infection. The company is also focused on creating next-generation combinatory gene-edited CAR-T therapies using strategies to improve efficacy while employing GM-CSF gene knockout technologies to control toxicity. In addition, the company is developing its own portfolio of proprietary first-in-class EphA3-CAR-T for various solid cancers and EMR1-CAR-T for various eosinophilic disorders. The company is also exploring the effectiveness of its GM-CSF neutralization technologies (either through the use of lenzilumab as a neutralizing antibody or through GM-CSF gene knockout) in combination with other CAR-T, bispecific or natural killer (NK) T cell engaging immunotherapy treatments to break the efficacy/toxicity linkage, including to prevent and/or treat graft-versus-host disease (GvHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Additionally, Humanigen and Kite, a Gilead Company, are evaluating lenzilumab in combination with Yescarta (axicabtagene ciloleucel) in patients with relapsed or refractory large B-cell lymphoma in a clinical collaboration. For more information, visit http://www.humanigen.com

Forward-Looking Statements

This release contains forward-looking statements. Forward-looking statements reflect management's current knowledge, assumptions, judgment and expectations regarding future performance or events. Although management believes that the expectations reflected in such statements are reasonable, they give no assurance that such expectations will prove to be correct and you should be aware that actual events or results may differ materially from those contained in the forward-looking statements. Words such as "will," "expect," "intend," "plan," "potential," "possible," "goals," "accelerate," "continue," and similar expressions identify forward-looking statements, including, without limitation, statements regarding our clinical and pre-clinical therapies and our development programs for them. Forward-looking statements are subject to a number of risks and uncertainties including, but not limited to our lack of profitability and need for additional capital; our dependence on partners to further the development of our product candidates; the uncertainties inherent in the development and launch of any new pharmaceutical product; the outcome of pending or future litigation; and the various risks and uncertainties described in the "Risk Factors" sections and elsewhere in the Company's periodic and other filings with the Securities and Exchange Commission.

All forward-looking statements are expressly qualified in their entirety by this cautionary notice. You should not place undue reliance on any forward-looking statements, which speak only as of the date of this release. We undertake no obligation to revise or update any forward-looking statements made in this press release to reflect events or circumstances after the date hereof or to reflect new information or the occurrence of unanticipated events, except as required by law.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200707005282/en/

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Humanigen Appoints Senior Executives to Management Team - BioSpace