Auxolytic’s Nutrient-Based Shut-Off Switch Boosts Cell Therapy Safety Without Transgenes – BioSpace

Auxolytic has developed a nutrient-based safety-switch for cell therapies that doesnt rely on introducing transgenes. The process, auxotrophy, uses the engineered inability of an organism to synthesize a compound required for its survival to allow physicians to turn off a gene therapy if serious side effects develop.

The work currently is in preclinical phases, in humanized cells in mice, and appears promising. When it advances to clinical applications, patients receiving cell therapies (such as CAR T, stem cell, and TCR therapies) containing this safety switch would be given supplements of a particular nutrient uridine, in this case. If the cell therapy went awry, patients could simply stop taking the uridine supplement and the cellular therapy would cease to function.

A paper published in Nature Biotechnology describes how the off switch could be engineered into cell therapies. Basically, it says, the approach knocks out the gene that disrupt(s) uridine monophosphate synthetase (UMPS) in the pyrimidine de novo synthesis pathway in cell lines, pluripotent cells, and primary human T cells.

This knockout makes proliferation of the cell therapy dependent on the external supply of uridine. Therefore, researchers can control cell growth by modulating the uridine supply in vitro and, importantly, in vivo after transplantation.

In the movie Jurassic Park, the dinosaurs were engineered to need lysine. If they escaped, there was no lysine to keep them alive. This therapy is very similar, founder and CEO James Patterson, M.D., Ph.D., told BioSpace.

Rather than lysine, Auxolytic uses uridine as the controlling nutrient. Uridine is important in carbohydrate metabolism and is found in yeast, tomatoes, broccoli, sugarcane and other foods, and also can be produced by the body when inadequate amounts are consumed in the diet.

The quantities available through the diet or produced by the body, however, arent high enough to sustain the engineered cells, Patterson said. Evidence comes from a rare genetic disease, orotic aciduria. Patients with that condition have a mutation in the UMPS gene that causes them to produce insufficient levels of the enzyme that breaks down orotic acid. They often die at very young ages if not supplied with quantities of pure uridine. This shows that a normal diet wont compensate.

Patients of cell therapies that incorporate Auxolytics nutrient-based safety switch likely would be able to eat their usual foods, but with nuridine added as a supplement. The approach Dr. Patterson developed hasnt been tested in patients yet.

This is the same nutrient I worked with in yeast, but now in human cells, Patterson said. Early work shows that only the engineered cell therapy would be affected by uridine modulation. Within one week of withdrawing the uridine, the engineered cells were inactive and unable to proliferate. Normal cells continued to function as usual.

At age 27, Patterson already has worked with many of the thought leaders in medicine and biomedical research while pursuing his M.D. and Ph.D. degrees at the University of Cambridge and the Francis Crick Institute. Beginning early during his university days, he performed research placements at the University of Zurich, The Gurdon Institute, The Whitehead Institute and The Cambridge Stem Cell Initiative.

This nutrient-based approach to controlling cell therapy is the direct result of that body of experience.

During my M.D./Ph.D. training, I became interested in cell therapy and its potential for curing patients, but there were safety risks. My Ph.D. work focused on yeast biology, studying how cells control their size. There, the idea of nutrient-based cell control was commonplace, but no one was working on this in human cells, he said. I became interested in science when I was very young, so during my undergraduate work I made sure I was thinking about the science being done in the labs in addition to what I was learning in lectures. Theres a difference.

Lectures lay the scientific foundation, but lab work is cutting-edge and forward-thinking.

I started working in labs when I was 19 in Zurich. I spent all my summers working in labs, asking a range of questions and working in lots of different systems, Patterson said.

Such broad exposure proved foundational for Auxolytic.

As you can see, this is a yeast technology. Thats not where you usually go to look for cell therapy ideas, he added.

He advises students early on to get into exciting labs that are doing interesting, fundamental science. Ask basic questions of how cells work, for example. You never know what youll find that could be applicable to the clinic. Jumping to clinical research (too early) causes you to lose the blue sky thinking.

Auxotyic, based in Cambridge, UK, is, for now, a virtual company of onebut with ample advisors.

Theyve helped along the way in the academic sector and also in the management of business, Patterson said. Those mentors include seasoned industry veterans who know what it takes to take a drug from bench to bedside, and who understand patenting and licensing.

The next step for Auxolytic, scientifically, is to identify potential applications around selecting for differentiated cells from induced pluripotent stem cells (iPSCs). Much of the scientific work is being done in collaboration with the Matthew H. Porteus lab at Stanford University.

On the business side, he continued, Were excited to get this into the hands of big cell therapy companies that currently are making cell therapies without a safety switch. Were looking to partner with them to get this to patients.

Auxolytic is talking with several interested companies. People recognize the need for a safety switch and are very excited, Patterson said. Discussions are going well.

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Auxolytic's Nutrient-Based Shut-Off Switch Boosts Cell Therapy Safety Without Transgenes - BioSpace

Market trends and outlook coupled with factors driving and restraining the growth of the Cell Imaging Systems market – Scientect

The most advanced study released by AMR on the Cell Imaging Systems market comprising key market segments such as Type, Application, Sales, Growth, Comprises details of companies manufacturing field, production volume, capacities, value chain, product specifications, raw material sourcing strategies, concentration rate, organizational structure, and distribution channel.

The COVID-19 outbreak is now traveling around the world, leaving a trail of destruction in its wake. This report discusses the impact of the virus on leading companies in the Cell Imaging Systems sector.

The research is a precise offset bridging both qualitative and quantitative data of Cell Imaging Systems market.

The study provides historical data to compare for evolving Sales, Revenue, Volume, Value of 2014 to 2019 and forecasted till 2026.

It becomes necessary to analyze the competitors progress while operating into the same competing environment, for that purpose, the report provides thorough insights into market competitors marketing strategies which include alliances, acquisitions, ventures, partnerships, as well as product launches, and brand promotions.

Cell Imaging Systems Market with Impact Analysis of COVID-19: Key Major Players areCarl Zeiss Microscopy, Etaluma, Inc, Thermo Fisher, Lumenera Corporation, Lonza, Molecular Devices LLC, GE Healthcare Life Science, Logos Biosystems, Perkin Elmer, Bio-Rad, Keyence Corporation, BioTek, Leica Microsystems, Nikon Instruments Inc..

Sample PDF Copy Instantly in your email box at: https://www.amplemarketreports.com/sample-request/covid-19-outbreak-global-cell-imaging-systems-industry-1957105.html

Cell Imaging Systems Research objectives

Focuses on the key global Cell Imaging Systems players, to define, describe and analyze the value, market share, market competition landscape, SWOT analysis, and development plans in the next few years.

Competitive Structure and analysis of The Cell Imaging Systems Market:

Some of the players have a stellar growth track record for 2014 to 2018, some of these companies have shown tremendous growth by sales and revenue while net income more than doubled in the same period with performing as well as gross margins expanding. The growth in gross margins over the years points to strong pricing power by the company for its products, over and above the increase in the cost of goods sold.

The report further features analysis that contains details of companies manufacturing base, production volume, sizes, value chain, product specifications.

According to AMR, key market segments sales will traverse the $$ mark in the year 2020. Unlike classified segments by Type (Confocal Microscopy, Phase Contrast Microscopy, Fluorescent Microscopy, Quantitative Phase Contrast Microscopy), by End-Users/Application (Drug Discovery, Stem Cells, Cell Biology, Developmental Biology).

2020 report version is the most advanced which is further divided and highlights a new emerging twist of the industry.

Cell Imaging Systems market will increase from $XX million in 2019 to strike $YY million by 2026, with a compound annual growth rate (CAGR) of xx%. The most robust growth is anticipated in Asia-Pacific, where CAGR is presumed to be ##% from 2019 to 2026. This prediction is good news for market players, as there is good potential for them to continue developing alongside the industrys projected growth.

Find out more on growth of Cell Imaging Systems market at: https://www.amplemarketreports.com/report/covid-19-outbreak-global-cell-imaging-systems-industry-1957105.html

Market players have determined strategies to offer a whole host of new product launches within several markets around the globe. Remarkable models are variant to be launched in eight EMEA markets in Q4 2019 and 2020. Acknowledging all-around exercises some of the players profiles that would be worth reviewing are Carl Zeiss Microscopy, Etaluma, Inc, Thermo Fisher, Lumenera Corporation, Lonza, Molecular Devices LLC, GE Healthcare Life Science, Logos Biosystems, Perkin Elmer, Bio-Rad, Keyence Corporation, BioTek, Leica Microsystems, Nikon Instruments Inc..

Although recent years might not be that inspiring as market segments have registered reasonable gains, things could have been better if manufacturers would have plan-driven move earlier. Unlike past, but with a decent estimate, investment cycle continuing to progress in the U.S., many growth opportunities ahead for the companies in 2020, it looks like a good for today but stronger returns can be expected beyond.

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Market trends and outlook coupled with factors driving and restraining the growth of the Cell Imaging Systems market - Scientect

New discovery explains how coronavirus may be able to infect cells – Health24

Early in the Covid-19 outbreak, Health24 wrote about the novel coronavirus and how it uses its spikes to dock onto the surface of human cells with the help of a receptor called ACE2.

Vaccine developers have centred their research around these spike proteins and ACE2 receptors, as it provided insight into how the virus triggers an immune response in humans.

According to a news release, German scientists including experts from of the European Molecular Biology Laboratory (EMBL) in Heidelberg, the Max Planck Institute of Biophysics, the Paul-Ehrlich-Institut, and Goethe University Frankfurt have been focusing on the surface structure of the virus to gain insights they can use for the development of vaccines and therapies to treat infected patients.

A flexible stalk

The team used a combination of cryo-electron tomography, subtomogram averaging and molecular dynamics simulations to analyse the exact molecular structure of the spike protein.

Their data showed that the globular portion of the spike protein, where the receptor-binding region is situated and helps the virus to successfully bind to human cells, is actually connected to a flexible stalk.

"The stalk was expected to be quite rigid," said Gerhard Hummer from the MPI of Biophysics and the Institute of Biophysics at Goethe University Frankfurt in a news release. "But in our computer models and in the actual images, we discovered that the stalks are extremely flexible.

The researchers were able to identify that the stalk had three hinges that give it its flexibility.

"Like a balloon on a string, the spikes appear to move on the surface of the virus and thus are able to search for the receptor for docking to the target cell," explains Jacomine Krijnse Locker, group leader at the Paul-Ehrlich-Institut.

What does this mean for future vaccine development?

The new research didnt only identify the flexibility of the spike protein, but also discovered that the entire protein, including the stalk, is coated with sugar-like molecules called glycans, which protect the spikes from antibodies.

This protective layer is an important discovery for vaccine and treatment development.

READ | Mutation helps coronavirus infect more cells, study shows

READ | How the coronavirus infects: It can make itself unrecognisable to cells in the body

READ | New coronavirus wasn't made in a lab, genomic study shows

Image credit: Getty Images

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New discovery explains how coronavirus may be able to infect cells - Health24

The global market for Peripheral Blood Mononuclear Cells (PBMC) is projected to grow at a CAGR of around 9% during 2020 – 2025 – GlobeNewswire

New York, Aug. 21, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Peripheral Blood Mononuclear Cells Market, By Product, By Application, By Technique, By Source, By Region, Competition, Forecast & Opportunities, 2025" - https://www.reportlinker.com/p05953172/?utm_source=GNW

The global market for Peripheral Blood Mononuclear Cells (PBMC) is projected to grow at a CAGR of around 9% during 2020 - 2025.The PBMC are crucial to carry out the biology and pathology related studies as well as in clinical research.

Besides, PBMCs are also utilized in research related to fatal diseases, immunology, vaccine development, etc. However, high cost of PBMCs related studies might act as a challenge for the adoption of technology, especially in developing economies. The global peripheral blood mononuclear cells market is segmented based on product, application, technique, source, and region.The product segment is further divided into cryopreserved or frozen PBMC, cultured or fresh PBMC and peripheral blood mononuclear cell isolation & viability kits.

As of 2019, the cryopreserved PBMC or the frozen PBMC segment held the highest market share as they can be used for longer durations of time if stored carefully at lower temperatures.In terms of regional analysis, North America accounted for the largest market share in the year 2019, on the back of a number of pre-existing peripheral blood mononuclear cells-based companies in the region.

The economy of the region is also rich enough, which makes it easier to carry out the complex and costly R&D procedures. Major players operating in the global peripheral blood mononuclear cells market include Astarte Biologics, Inc., ATZLabs, BioIVT, BioLegend, Inc., BioVision, Bio-Rad, Cell Applications, Inc., Celgene, Creative Bioarray, Dapcel, Inc, HemaCare, iXCells Biotechnologies, Miltenyi Biotec, Merck, Novo Nordisk, Precision Medicine, Qiagen NV, STEMCELL Technologies Inc., Thermo Fisher Scientific, ZenBio, Inc., etc.

Years considered for this report:

Historical Years: 2015 - 2018 Base Year: 2019 Estimated Year: 2020 Forecast Period: 2021 - 2025

Objective of the Study:

To analyze and forecast the market size of global peripheral blood mononuclear cells market. To classify and forecast global peripheral blood mononuclear cells market based on product, application, technique, source, and region. To identify drivers and challenges for global peripheral blood mononuclear cells market. To examine competitive developments such as expansions, new product launches, mergers & acquisitions, etc., in global peripheral blood mononuclear cells market. To conduct pricing analysis for global peripheral blood mononuclear cells market. To identify and analyze the profile of leading players operating in global peripheral blood mononuclear cells market. The analyst performed both primary as well as exhaustive secondary research for this study.Initially, the analyst sourced a list of leading market players across the globe.

Subsequently, the analyst conducted primary research surveys with the identified companies.While interviewing, the respondents were also enquired about their competitors.

Through this technique, the analyst could include the research organizations and companies which could not be identified due to the limitations of secondary research. The analyst examined the research organizations and companies, and presence of all major players across the globe. The analyst calculated the market size of global peripheral blood mononuclear cells market using a bottom-up approach, wherein data for various end-user segments was recorded and forecast for the future years. The analyst sourced these values from the industry experts and company representatives and externally validated through analyzing historical data of these product types and applications for getting an appropriate, overall market size.

Various secondary sources such as company websites, news articles, press releases, company annual reports, investor presentations and financial reports were also studied by the analyst.

Key Target Audience:

Biotechnology and pharma companies and other stakeholders Government bodies such as regulating authorities and policy makers Organizations, forums and alliances related to peripheral blood mononuclear cells Market research and consulting firms The study is useful in providing answers to several critical questions that are important for the industry stakeholders such as research organizations & companies and partners, end users, etc., besides allowing them in strategizing investments and capitalizing on market opportunities.

Report Scope:

In this report, global peripheral blood mononuclear cells market has been segmented into following categories, in addition to the industry trends which have also been detailed below: Market, By Product: o Cryopreserved or Frozen PBMC o Cultured or Fresh PBMC o Peripheral Blood Mononuclear Cell Isolation & Viability Kits Market, By Application: o Immunology o Infectious disease o Hematology o Others Market, By Technique: o Density gradient centrifugation process o Leukapheresis Market, By Source: o Human o Animals Market, By Region: o Asia-Pacific - China - India - Japan - South Korea - Singapore - Australia o Europe - France - Germany - United Kingdom - Italy o North America - United States - Mexico - Canada o South America - Brazil - Argentina - Colombia o Middle east & Africa - South Africa - Saudi Arabia - UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in global peripheral blood mononuclear cells market.

Available Customizations:

With the given market data, we offers customizations according to a companys specific needs. The following customization options are available for the report:

Company Information

Detailed analysis and profiling of additional market players (up to five).Read the full report: https://www.reportlinker.com/p05953172/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The global market for Peripheral Blood Mononuclear Cells (PBMC) is projected to grow at a CAGR of around 9% during 2020 - 2025 - GlobeNewswire

Tips to help kids cope with the stress of online learning with health and human behavior expert Dr. Alok Trivedi – KTLA

Master trainer for AKT Alissa Tucker joined us to tell us all about AKT and the workout classes they offer.AKT is known for their dance cardio classes.Celebs like Alicia Keys, Shakira and Kelly Ripa are fans of the workout.Theyve expanded their classes to include bands, tone and circuit training as well.And theyre now offering outdoor classes at their Yorba Linda location.For more info, you can visit their websiteor follow them on Instagram @TheAKTStudiosThis segment aired on the KTLA 5 Morning News on August 20, 2020.

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Tips to help kids cope with the stress of online learning with health and human behavior expert Dr. Alok Trivedi - KTLA

Letter to the Editor 8/21: Hybrid learning is the wrong approach – The Daily Gazette

Hybrid learning is the wrong approach

Currently, schools in New York state are considering plans for reopening using a combination of distance teaching and classroom teaching.This hybrid approach might work in a few unique school settings. However, for most school districts, this approach will not work for the reasons noted below.1. Human behavior is imperfect.We all tend to take shortcuts occasionally. Will protocols always be followed inside and outside the classrooms? Errors in judgment can always have negative consequences on the best of plans.2. COVID-19 testing time.The plans typically are based on a 24-hour turnaround for COVID-19 testing. I am skeptical about achieving this target given current experience with testing turnaround times, and the additional load presented by opening schools.3. Not all schools are equal.Schools in poor, crowded, and underserved areas will not have the resources necessary to carry out the protocols required for safely opening classrooms.4. Asymptomatic carriers. Infected people who have no symptoms may not be detected. These individuals shed the virus and can cause an outbreak.I believe that the best use of the limited resources should be directed to enhancing distance learning, since this will be the most likely mode during the fall semester.Don SteinerSchenectady

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Letter to the Editor 8/21: Hybrid learning is the wrong approach - The Daily Gazette

The long, complicated history of people analytics – MIT Technology Review

Or perhaps you work for one of the health-care, retail, or financial-services companies that use software developed by Receptiviti. The Toronto-based companys mission is to help machines understand people by scanning emails and Slack messages for linguistic hints of unhappiness. We worry about the perception of Big Brother, Receptivitis CEO recently told the Wall Street Journal. He prefers calling employee surveillance corporate mindfulness. (Orwell would have had something to say about that euphemism, too.)

Such efforts at what its creators call people analytics are usually justified on the grounds of improving efficiency or the customer experience. In recent months, some governments and public health experts have advocated tracking and tracing applications as a means of stopping the spread of covid-19.

But in embracing these technologies, businesses and governments often avoid answering crucial questions: Who should know what about you? Is what they know accurate? What should they be able to do with that information? And is it ever possible to devise a proven formula for assessing human behavior?

Such questions have a history, but todays technologists dont seem to know it. They prefer to focus on the novel and ingenious ways their inventions can improve the human experience (or the corporate bottom line) rather than the ways people in previous eras have tried and failed to do the same. Each new algorithm or app is, in their view, an implicit rebuke of the past.

But that past can offer some much-needed guidance and humility. Despite faster computers and more sophisticated algorithms, todays people analytics is fueled by an age-old reductive conceit: the notion that human nature in all its complexities can be reduced to a formula. We know enough about human behavior to exploit each others weaknesses, but not enough to significantly change it, except perhaps on the margins.

If Then, a new book by Jill Lepore, a historian at Harvard University and staff writer at the New Yorker, tells the story of a forgotten mid-20th-century technology company called the Simulmatics Corporation. Founded by a motley group of scientists and advertising men in 1959, it was, Lepore claims, Cold War Americas Cambridge Analytica.

A more accurate description might be that it was an effort by Democrats to compete with the Republican Partys embrace of the techniques of advertising. By midcentury, Republicans were selling politicians to the public as though they were toilet paper or coffee. Simulmatics, which set up shop in New York City (but had to rent time on IBMs computers to run its calculations), promised to predict the outcome of elections nearly in real timea practice now so common it is mundane, but one then seen as groundbreaking, if not impossible.

The companys name, a portmanteau of simulation and automatic, was a measure of its creators ambition: to automate the simulation of human behavior. Its main tool was the People Machine, which Lepore describes as a computer program designed to predict and manipulate human behavior, all sorts of human behavior, from buying a dishwasher to countering an insurgency to casting a vote. It worked by developing categories of people (such as white working-class Catholic or suburban Republican mother) and simulating their likely decision-making. (Targeted advertising and political campaigning today use broadly similar techniques.)

The companys key players were drawn from a range of backgrounds. Advertising man Ed Greenfield was one of the first to glimpse how the new technology of television would revolutionize politics and became convinced that the earliest computers would exercise a similarly disruptive force on democracy. Ithiel de Sola Pool, an ambitious social scientist eager to work with the government to uncover the secrets of human behavior, eventually became one of the first, prescient theorists of social networks.

More than any other Simulmatics man, Pool embodied both the idealistic fervor and the heedlessness about norm-breaking that characterize technological innovators today. The son of radical parents who himself dabbled in socialism as a young man, he spent the rest of his life proving himself a committed Cold War patriot, and he once described his Simulmatics work as a kind of Manhattan Project gamble in politics.

One of the companys first big clients was John F. Kennedys presidential campaign in 1960. When Kennedy won, the company claimed credit. But it also faced fears that the machine it had built could be turned to nefarious purposes. As one scientist said in a Harpers magazine expos of the company published shortly after the election, You cant simulate the consequences of simulation. The public feared that companies like Simulmatics could have a corrupting influence on the democratic process. This, remember, was nearly half a century before Facebook was even founded.

One branch of government, though, was enthusiastic about the companys predictive capabilities: the Department of Defense. As Lepore reminds readers, close partnerships between technologists and the Pentagon were viewed as necessary, patriotic efforts to stem the tide of Communism during the Cold War.

MIT MUSEUM (POOL); RICHARD RODSTEIN | WIKIMEDIA VIA CC SA (POOL, 1953); LBJ PRESIDENTIAL LIBRARY FOLDER: RECORDS OF THE NACCD, SERIES 39, BOX 7

By 1966, Pool had accepted a contract to oversee a large-scale behavioral-science project for the Department of Defense in Saigon. Vietnam is the greatest social-science laboratory we have ever had! he enthused. Like Secretary of Defense Robert McNamara (whom Barry Goldwater once referred to as an IBM machine with legs and who commissioned the research), Pool believed the war would be won in the hearts and minds of the Vietnamese, and that it required behavioral-science modeling and simulation to win. As Lepore writes, Pool argued that while statesmen in times past had consulted philosophy, literature, and history, statesmen of the Cold War were obligated to consult the behavioral sciences.

Their efforts at computer-enabled counterinsurgency were a disastrous failure, in large part because Simulmatics data about the Vietnamese was partial and its simulations based more on wishful thinking than realities on the ground. But this didnt prevent the federal government from coming back to Pool and Simulmatics for help understandingand predictingcivil unrest back home.

The Kerner Commission, convened by President Lyndon Johnson in 1967 to study the race riots that had broken out across the country, paid Simulmatics Urban Studies Division to devise a predictive formula for riots to alert authorities to brewing unrest before it devolved into disorder. Like the predictions for Vietnam, these too proved dubious. By the 1970s, Simulmatics had declared bankruptcy, and the automated computer simulation of human behavior had fallen into disrepute, according to Lepore.

The profit-motivated collection and use of data about human behavior, unregulated by any governmental body, has wreaked havoc on human societies.

Simulmatics lurks behind the screen of every device we use, Lepore argues, and she claims its creators, the long-dead, white-whiskered grandfathers of Mark Zuckerberg and Sergey Brin and Jeff Bezos and Peter Thiel and Marc Andreessen and Elon Musk, are a missing link in the history of technology. But this is an overreach. The dream of sorting and categorizing and analyzing people has been a constant throughout history. Simulmatics effort was merely one of many, and hardly revolutionary.

Far more historically significant (and harmful) were 19th-century projects to categorize criminals, or early 20th-century campaigns to predict behavior based on pseudoscientific categories of race and ethnicity during the height of the eugenics movement. All these projects, too, relied on data collection and systematization and on partnerships with local and state governments for their success, but they also garnered significant enthusiasm from large swaths of the public, something Simulmatics never did.

What is true is that Simulmatics combination of idealism and hubris resembles that of many contemporary Silicon Valley companies. Like them, it viewed itself as the leading edge of a new Enlightenment, led by the people best suited to solve societys problems, even as they failed to grasp the complexity and diversity of that society. It would be easier, more comforting, less unsettling, if the scientists of Simulmatics were villains, Lepore writes. But they werent. They were midcentury white liberals in an era when white liberals were not expected to understand people who werent white or liberal. Where the Simulmatics Corporation believed that the same formula could understand populations as distinct as American voters and Vietnamese villagers, todays predictive technologies often make similarly grandiose promises. Fueled by far more sophisticated data gathering and analysis, they still fail to account for the full range and richness of human complexity and variation.

So although Simulmatics did not, as Lepores subtitle claims, invent the future, its attempts to categorize and forecast human behavior raised questions about the ethics of data that are still with us today. Lepore describes congressional hearings about data privacy in 1966, when a scientist from RAND outlined for Congress the questions it should be asking: What is data? To whom does data belong? What obligation does the collector, or holder, or analyst of data hold over the subject of the data? Can data be shared? Can it be sold?

Lepore laments a previous eras failure to tackle such questions head-on. If, then, in the 1960s, things had gone differently, this future might have been saved, she writes, adding that plenty of people believed at the time that a people machine was entirely and utterly amoral. But it is also oddly reassuring to learn that even when our technologies were in their rudimentary stages, people were thinking through the likely consequences of our use of them.

As Lepore writes, Simulmatics was hobbled by the technological limitations of the 1960s: Data was scarce. Models were weak. Computers were slow. The machine faltered, and the men who built it could not repair it. But though todays people machines are sleeker, faster, and seemingly unstoppable, they are not fundamentally different from that of Simulmatics. Both are based on a belief that mathematical laws of human nature are real, in the way that the laws of physics area false belief, Lepore notes:

The study of human behavior is not the same as the study of the spread of viruses and the density of clouds and the movement of the stars. Human behavior does not follow laws like the law of gravity, and to believe that it does is to take an oath to a new religion. Predestination can be a dangerous gospel. The profit-motivated collection and use of data about human behavior, unregulated by any governmental body, has wreaked havoc on human societies, especially on the spheres in which Simulmatics engaged: politics, advertising, journalism, counterinsurgency, and race relations.

While Simulmatics failed because it was ahead of its time, its modern counterparts are more powerful and more profitable. But remembering its story can help clarify the deficiencies of a society built on reductive beliefs about the power of data, and illuminate a path toward a dignified, vibrant, human future.

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The long, complicated history of people analytics - MIT Technology Review

Six book recommendations for your summer staycation from the Graduate School of Business | The Dish – Stanford University News

by Jenny Luna & Steve Hawk on August 18, 2020 3:42 pm

The Graduate School of Business asked its professors to reveal what theyve been reading this summer. Their responses range from insights into the neurological origins of human behavior to a debunking of the belief that businesses exist only to make money. As the closing weeks of summer approach, carve out some quiet time and dive in.

From neurobiology to capitalism reimagined, here are some books to enrich your summer. (Image credit: iStock)

ROBERT JOSS, the Philip H. Knight Professor and Dean, Emeritus: Reimagining Capitalism in a World on Fire by Rebecca Henderson.

This book has an important message about the critical role of purpose-driven businesses in our society and how capitalism and democracy need to interact constructively to solve our most pressing challenges.

SUZIE NOH, assistant professor of accounting: Shoe Dog: A Memoir by the Creator of Nike by Phil Knight.

This book provides an inspiring and captivating story of how Phil Knight turned a small startup into the worlds most iconic company. It is filled with helpful tips on how to be a successful businessperson. Id recommend it to all aspiring entrepreneurs.

KEVIN SMITH, assistant professor of accounting: Behave: The Biology of Humans at Our Best and Worstby Robert Sapolsky.

A fascinating, state-of-the-art exploration of the enormity of factors that influence human behavior. While the book contains a multitude of insights, one that stands out is that the relationship between behavior, hormones and neurochemicals is far more complicated than typically conveyed in popular science.

Read the full reading list on the Graduate School of Business website.

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Six book recommendations for your summer staycation from the Graduate School of Business | The Dish - Stanford University News

Fish and Game reminding folks to lock up their trash – 6 On Your Side

BLAINE COUNTY, Idaho Idaho Fish and Game says they've been getting more calls in the Wood River Valley about bears getting into garbage.

It's a dangerous situation not just for people, but for the bear.

"This is a human-caused problem," explained Terry Thompson, Fish and Game Magic Valley's Communications Director. "There's a saying, 'a fed bear is a dead bear.' Unfortunately, that is the case. Food-conditioned bears are a threat to public safety."

Food-conditioned means the bear becomes used to receiving food from human sources like unsecured garbage.

"That's a bad situation," Thompson said. "Bears learn very quickly where they can find food. The problem is, you can't unlearn that behavior."

Thompson explains non-lethal options like trying to relocate a food-conditioned bear usually does more harm than good: the bear will either come back, search for food in the communities in its new area, or it could have territorial issues with another bear already in the area.

"Relocating makes us feel good as humans, but for the outcome of the bear, it doesn't end well," Thompson explained.

That's why Fish and Game says often, their only option once a bear becomes food-conditioned is to euthanize it.

"What we've found is it's much easier to change human behavior than it is to change wildlife behavior, so our goal, what we want to see in the Wood River Valley especially, is we want to see residents change their behavior in how they secure their garbage so we don't have to euthanize a bear because of public safety issues," Thompson said.

Fish and Game says it's best to secure your garbage in your garage or a locked shed. They also recommend waiting until the morning of trash day to bring your trash cans to the curb.

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The Mythology of Karen – The Atlantic

What does it mean to call a woman a Karen? The origins of any meme are hard to pin down, and this one has spread with the same intensity as the coronavirus, and often in parallel with it. Karens are the policewomen of all human behavior. Karens dont believe in vaccines. Karens have short hair. Karens are selfish. Confusingly, Karens are both the kind of petty enforcers who patrol other peoples failures at social distancing, and the kind of entitled women who refuse to wear a mask because its a muzzle.

Oh, and Karens are most definitely white. Let that ease your conscience if you were beginning to wonder whether the meme was, perhaps, a little bit sexist in identifying various universal negative behaviors and attributing them exclusively to women. Because Karen is white, she faces few meaningful repercussions, wrote Robin Abcarian in the Los Angeles Times. Embarrassing videos posted on social media is usually as bad as it gets for Karen.

Sorry, but no. You cant control a word, or an idea, once its been released into the wild. Epithets linked to women have a habit of becoming sexist insults; we dont tend to describe men as bossy, ditzy, or nasty. Theyre not called mean girls or prima donnas or drama queens, even when they totally are. And so Karen has followed the trajectory of dozens of words before it, becoming a cloak for casual sexism as well as a method of criticizing the perceived faux vulnerability of white women.

To understand why the Karen debate has been so fierce and emotive, you need to understand the two separate (and opposing) traditions on which it draws: anti-racism and sexism. You also need to understand the challenge that white women as a group pose to modern activist culture. When so many online debates involve mentally awarding privilege points to each side of an encounter or argument to adjudicate who holds the most power, the confusing status of white women jams the signal. Are they the oppressors or the oppressed? Worse than that, what if they are using their apparent disadvantagebeing a womanas a weapon?

One phrase above all has come to encapsulate the essence of a Karen: She is the kind of woman who asks to speak to the manager. In doing so, Karen is causing trouble for others. It is taken as read that her complaint is bogus, or at least disproportionate to the vigor with which she pursues it. The target of Karens entitled anger is typically presumed to be a racial minority or a working-class person, and so she is executing a covert maneuver: using her white femininity to present herself as a victim, when she is really the aggressor.

Read: How a popular joke about entitled white women became a pandemic meme

Call Donald Trump the ultimate Karen if you like, but the words powerits punchcomes from the frequently fraught cultural space white women in the United States have occupied for generations. This includes the schism between white suffragists and the abolitionist movement, where prominent white women expressed affronted rage that Black men might be granted the vote ahead of them. If intelligence, justice and morality are to have precedence in the government, let the question of women be brought up first and that of the negro last, declared Susan B. Anthony in 1869 at a conference of the American Equal Rights Association. (She was responding to the suggestion by Frederick Douglass that Black male enfranchisement was a more urgent issue than womens suffrage.) There are also echoes in the Scottsboro Boys case, where eight Black men were wrongly convicted of raping two white women in 1930s Alabama; and the rape of the Central Park jogger, where the horrifying violence suffered by a white woman was the pretext for the states persecution of innocent men.

The tension is even more obvious in another infamous case. In August 1955, Carolyn Bryant Donham was 21 years old, and working in a store she owned with her husband, Roy Bryant, in the Mississippi Delta. A Black teenage boy walked into the store, and thenwell, no one knows, exactly. Bryant Donhams initial story was that he wolf-whistled at her. In court, later, she said he grabbed her, insulted her, and told her hed been with white women before. Decades later, she said that she had made it all up, and couldnt remember exactly what had happened.

None of that made any difference to the boy, who was hunted down by Roy Bryant and killed. His body was found days later, so mutilated that his mother insisted on an open-casket funeral, which would force the world to witness what had been done to him. His name was Emmett Till.

That story is vital to understanding Americas Karen mythology. A white womans complaint led white male authority to enact violence on a Black person, and neither she nor they suffered any consequences. Roy Bryant and his half brother were put on trial for Tills murder, but acquitted by an all-white, all-male jury. Within a racist, patriarchal system, Bryant Donhams fragilityher white femininitywas not a weakness, but a weapon, because she could always call on white men to protect her. (Yet even that case is more morally complex than it once seemed. In 2017, the Duke University professor Timothy B. Tyson, who was researching a book on the case, discovered that Roy Bryant was physically abusive to his wife. The circumstances under which she told the story were coercive, he told The New York Times. Shes horrified by it. Theres clearly a great burden of guilt and sorrow.)

All of this is why the earnest feminist contribution to the Karen debatewhy isnt there a name for haughty, shouty men who make customer-service complaints, or call the police on Black people, putting them in danger?is irrelevant. There doesnt need to be a word for that, because the concept being invoked here is the faux victim. Although they differ vastly in magnitude, a direct line of descent can be traced from the Till case to the Central Park Karen, a white woman named Amy Cooper who called the New York City police earlier this year claiming that a Black male bird-watcher was threatening her. (Cooper lost her job and is facing criminal charges for filing a false report.) A white womans tears were, again, a weapon to unleash the authoritiesstill coded white and male, despite the advances we have made since the 1950supon a Black man.

Read: 163 years of The Atlantics writing on race and racism in America

The potency of the Karen mythology is yet more proof that the internet speaks American. Here in Britain, there is no direct equivalent of the Till case, and voting rights were never restricted on racial lines. The big splits in the British suffrage movement were between violent and nonviolent tactics, and on whether men under 30 should receive the vote before women. Yet British newspapers have rushed to explain the Karen meme to their readers, because Twitter, Facebook, and Instagramthe prime sites for Karen-spottingare widely used in this country. (In fact, the Karen discussion has spread throughout the English-speaking internet, reaching as far as New Zealand.)

At some point, though, the particular American history behind Karen got lost. What started as an indictment of racial privilege has become divorced from its original context, and is now a catchall term for shaming women online.

Not very much unites the rapper Ice T and the alt-right activist Paul Joseph Watson of InfoWars, but both can agree on this: Karens are a menace. In July, Ice T identified a Karen of the Day, tweeting a video of a woman who refused to wear a mask in a dentists office. It was another instance of the memes suspicious flexibility: Is a Karen a woman flouting the rules or pettily enforcing them? (Never mind the fact that research shows men are less likely to wear masks, anyway.)

Watsons take was even more revealing, because he was not playing to an audience that considers itself progressive. That means he can say the quiet part out loud. In one YouTube video with nearly 1 million views, Watson defines a Karen as an annoying, interfering female adult, who complains about everything. The first clip in his compilation is of a man cycling past a woman, who tells the cyclist briskly but not angrily: Thats not social distancing.

Cut to Watson: Okay, Karen.

Cut back to the man on the bike, incredulous at being challenged. Stupid bitch, shut up.

Read: The coronavirus is a disaster for feminism

This is the hazard of memes, as well as the phenomenon of viral shaming more broadly. Theres no arbiter to decide which Karens are really acting in egregious or racist ways before the millionth like or view is reached, or their names are publicly revealed. Karen has become synonymous with woman among those who consider woman an insult. There is now a market, measured in attention and approbation, for anyone who can sniff out a Karen.

Whenever the potential sexism of the Karen meme has been raised, the standard reply has been that it originated in Black womens critiques of racism, that white women have more privilege than Black women, and that therefore identifying and chastising Karens is a form of punching up. In February, Aja Romano of Vox defined Karens as officious white women ruining the party for everyone else, adding that Black culture in particular has a history of assigning basic nicknames to badly behaved white women [from] Barbecue Becky and Golfcart Gail to Permit Patty and Talkback Tammy. Calling the Karen meme sexist, according to The Washington Posts Karen Attiah, only trivializes actual violence and discrimination that destroy lives and communities. And to invent oppression when none is happening to you? That is peak Karen behavior.

The best way to see the Karen meme is as a scissor, an idea popularized by the writer Scott Alexander of Slate Star Codex to describe an incident or a statement that drives people to such wildly divergent interpretations that they can never be reconciled. Because white women can be both oppressors and oppressed, Karen is a scissor. Does the word describe a particular type of behavior that resonates because of the particular racial history of the United States? Yes. Is that the only way it is used? No.

As it happens, the casually sexist roots of the meme are as deep as the anti-racist ones. One of the foundational internet Karens was the ex-wife of a Redditor who chronicled their fraught relationship in the subreddit r/FuckYouKaren, created in December 2017. The intensity of the blowback when pointing facts like this out is itself instructive. The chorus of disdain that greets any white woman who questions the Karen meme comes from a broad, and unexpected, coalition: anti-racists and bog-standard misogynists. (Finally, a political stance to bring this troubled world together.)

Read: How the pandemic revealed Britains national illness

For the same reason, the Karen meme divides white women themselves. On one side are those who register its sexist uses, who feel the familiar tang of misogyny. Women are too loud, too demanding, too entitled. Others push aside those echoes, reasoning that if Black women want a word to describe their experience of racism, they should be allowed to have it. Hanging over white womens decision on which way to jump is a classic finger trap, familiar to anyone who has confronted a sexist joke, only to be told that they dont have a sense of humor. What is more Karen than complaining about being called Karen? There is a strong incentive to be cool about other women being Karened, lest you be Karened yourself.

In her 1991 essay From Practice to Theory, or What is a White Woman Anyway? the feminist and legal scholar Catharine MacKinnon referenced the Till case to explain the malignant stereotype that has grown up around the white woman in the United States. This creature is not poor, not battered, not raped (not really), not molested as a child, not pregnant as a teenager, not prostituted, not coerced into pornography, not a welfare mother, and not economically exploited, wrote MacKinnon. She is Miss Anne of the kitchen, she puts Frederick Douglass to the lash, she cries rape when Emmett Till looks at her sideways, she manipulates white mens very real power with the lifting of her very well-manicured little finger. She might have added, echoing the LA Times: Nothing worse happens to the white woman than a viral-video shaming.

Read: The epic political battle over the legacy of the suffragettes

MacKinnons point was that sexism existed, and even whiteness did not protect women from suffering it. (A response to MacKinnon by the Yale Collective on Women of Color and the Law contested some of her points, but agreed that feminism had to address the very real oppression suffered by women, despite any access women may have to social privilege.) Call the Karen meme sexist, though, and you will stumble into the middle of a Venn diagram, where progressive activists and anti-feminists can agree with each other: When white women say theyve been raped, we should doubt them, because we know white women lie. And underneath that: What do white women have to complain about, anyway?

Ageism is also a factor. As a name, Karen peaked in the U.S. in the 1960s, and is now rare for newborns, so todays Karen is likely to be well into middle age. As women shout and rant and protest in out-of-context clips designed to paint them in the most viral-friendly light possible, they are portrayed as witches, harridans, harpies: women who dare to keep existing, speaking, and asking to see the manager, after their reproductive peak.

In her essay, MacKinnon wrote that it was hard for women to organize as women. Many of us, she wrote, are more comfortable organizing around identities we share with men, such as gay rights or civil rights. I sense here that people feel more dignity in being part of any group that includes men than in being part of a group that includes that ultimate reduction of the notion of oppression, that instigator of lynch mobs, that ludicrous whiner, that equality coattails rider, the white woman, she added. It seems that if your oppression is also done to a man, you are more likely to be recognized as oppressed as opposed to inferior. That is the minefield that anyone who wants to use the Karen meme to punch up has to traverse. You will find yourself in unsavory company alongside those who see white women as ludicrous whiners.

In 2011, writing in The Atlantic, Ta-Nehisi Coates acknowledged the sexism that suffragists such as Elizabeth Cady Stanton and Sarah Grimk faced from fellow abolitionists, and their sense of being told again and again that womens rights were important, sure, but not urgent. Coates does not acquit these white suffragists of racial entitlement, but adds: When the goalabolitionwas achieved, they hoped for some reciprocity. It did not come. Without excusing their lack of solidarity, he attempts to understand it. The Nineteenth Amendment, which gave women the vote, came nearly 50 years after the Fifteenth, which ruled that voting rights could not be restricted on account of race, color, or previous condition of servitude.

Read: Why women still cant have it all

This uneasy history explains why the Karen debate has become so furious. It prods at several questions that are too painful for many of us to address. How far does white skin shield a woman from sexism? Do women cry rape with enough frequency to concern us, or is that another misogynist myth? How do Black women navigate competing demands for solidarity from their white sisters and their Black brothers? Does it still feel like punching up if youre joined by anti-feminists such as Watson, and a guy on a bike who shouts stupid bitch at women he doesnt like? And why is it okay to be more angry with the white women questioning the Karen meme than the white men appropriating it?

The Karen debate can, and perhaps will, go on forever, because it is equally defensible to argue that white women are oppressed for their sex, and privileged by their race. (Half victim, half accomplice, like everyone else, in Simone de Beauvoirs phrase.) If successive generations of schoolchildren can see that, maybe adults can too. After all, the most potent echo of the Till case in literature comes from Harper Lees To Kill A Mockingbird, published five years after the 14-year-olds murder. In the book, white trash Mayella Ewell testifies that her familys Black servant, Tom Robinson, raped her. It is a lie. The books hero, the lawyer Atticus Finch, exposes that lie only by also revealing Mayellas real trauma: She came on to Tom, and was beaten savagely by her father, Bob, as a result. Bob Ewells capacity for extreme violence is further demonstrated when he attempts to kill Finchs children in revenge for being humiliated in court. Mayella Ewell is half victim, half accomplicea victim of male violence, and an accomplice to white supremacy.

Her story, therefore, is one of both complicity and oppression. It is not simple or easy. No wonder it was so challenging then, and no wonder our feelings toward her daughters, the internets hated Karens, are so challenging now.

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The Mythology of Karen - The Atlantic