https://100women.avancemedia.org/2020-honourees/RashaKelej has been recognized for her efforts through Merck Foundation programs to train thousands of African doctors, to support African communities during Coronavirus lockdown and to empower girls in education so that they can reach their potential and pursue their dreams through "Educating Linda" program. This is for the second time, as she made the 100 Most Influential Africans (women and men) in 2019 by New African Magazine, UK, for empowering women in general and infertile women in particular through the "Merck More Than a Mother" campaign, which is a historic movement that aims to empower childless and infertile women through access to information, education, and change of mind-sets.Dr. RashaKelej is very well respected in the African Communities at all levels and this for her dedication and passion to unleash the potential of young Africans and her coherent strategy and implementation of serious programs that shape the Public healthcare landscape in Africa positively. More than a thousand young doctors from 35 countries have benefited from unique opportunities of specialty education in many fields such as diabetes, cardiovascular, endocrinology, sexual and reproductive medicines, respiratory, acute medicines, oncology, fertility, embryology, and scientific research.Expressing gratitude on the recognition, Dr. RashaKelej emphasized, "I feel honored and proud to receive this recognition and to be included in this prestigious list among such renowned African women from all spheres of life. This is an important recognition not only for me but to Merck Foundation and our team. As an African and an Egyptian woman, I have a great passion for improving access to equitable and quality healthcare solutions for all Africans. I am very lucky to work as CEO of Merck Foundation as I am empowered by them to realize our unique vision through such successful pan African programs in partnership with African First Ladies, to contribute to the future of these girls as part of our signature campaign "Merck More Than a Mother". I strongly believe that empowering women starts with education, to enable them to be healthier, stronger, and independent.""This recognition will also encourage and motivate me to empower the talented girls of my beautiful continent. I promise to use my influence to support and empower women, support girl child education, and build healthcare capacity in Africa, Asia and beyond", added Dr. RashaKelej.The list has a representation of the most powerful African women from 34 countries, chosen from various career backgrounds including diplomacy, philanthropy, politics, activism, entrepreneurship, business leadership, and entertainment. It includes many famous names like; H. E. Monica Geingos, The First Lady of Namibia; H.E. Elene Sirleaf, Former President of Liberia, amongst others.Dr. RashaKelej, CEO of Merck Foundation and president of "Merck More Than a Mother" was recognized last year as one of most influential Africans in 2019 to acknowledge her efforts to empower infertile women through the historic campaign "Merck More Than a Mother".She has been able to work in long term partnerships with 18 African First Ladies as Ambassadors of Merck More Than a Mother to build local healthcare capacity, empower girls in education and break infertility stigma across the continent.RashaKelej Facebook: https://www.facebook.com/KelejRasha/RashaKelej Twitter: http://www.twitter.com/rashakelejRashaKelej Instagram: http://www.instagram.com/rasha_kelejFor more information on Merck Foundation, please visit: http://www.merck-foundation.comTo view the list of 100 Most Influential African Women 2020, please visit:https://100women.avancemedia.org/2020-honourees/This story is provided by BusinessWire India. ANI will not be responsible in any way for the content of the article. (ANI/BusinessWire India)
Global Biochemistry Analyzer Market 2020 | Know the Companies List Could Potentially Benefit or Loose out From the Impact of COVID-19 | Top Companies:…
A perfect mix of quantitative & qualitative Biochemistry Analyzermarket information highlighting developments, industry challenges that competitors are facing along with gaps and opportunities available and would trend in Biochemistry Analyzer market. The study bridges the historical data from 2014 to 2019 and estimated until 2026.
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1 Biochemistry Analyzer Biochemistry Analyzer Market Overview2 Biochemistry Analyzer Market Competition by Manufacturers3 Production Capacity by Region4 Global Biochemistry Analyzer Market by Regions5 Production, Revenue, Price Trend by Type6 Global Biochemistry Analyzer Market Analysis by Application7 Company Profiles and Key Figures in Biochemistry Analyzer Business8 Biochemistry Analyzer Manufacturing Cost Analysis9 Marketing Channel, Distributors and Customers10 Market Dynamics11 Production and Supply Forecast12 Consumption and Demand Forecast13 Forecast by Type and by Application (2021-2026)14 Research Finding and Conclusion15 Methodology and Data Source.
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Global Biochemistry Analyzer Market 2020 | Know the Companies List Could Potentially Benefit or Loose out From the Impact of COVID-19 | Top Companies:...
Biochemistry Analyzers Market Size, Sales, Growth Drivers and Forecast to 2027 Hologic, Thermo Fisher Scientific, Randox Laboratories, Beckman…
Worldwide Biochemistry Analyzers Market Analysis to 2027 is a specialized and in-depth study of the Biochemistry Analyzers Industry with a focus on the global market trend. The report aims to provide an overview of global Biochemistry Analyzers Market with detailed market segmentation by product/application and geography. The global Biochemistry Analyzers Market is expected to witness high growth during the forecast period. The report provides key statistics on the Market status of the Biochemistry Analyzers players and offers key trends and opportunities in the market.
Biochemistry analyzers are new-generation analyzers that are used by hospitals, diagnostic centers, pharmaceutical and biopharmaceutical companies, and contract research organizations to perform various tasks such as routine biochemistry tests, electrolytic tests, hormonal assays, drug-enzyme investigations among others. These analyzers are gaining significant popularity in the market as it is capable of performing multi-functional applications with reliable results. These analyzers are available in the market with various levels of automation.
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The growth of global biochemistry analyzers market is majorly driven due to increasing adoption of automation in laboratories for quicker and reliable results, increasing healthcare expenditure, and increasing need of immediate diagnosis of various diseases. Various other factors responsible for the market growth includes development of technologically advanced analyzers and low cost of the analyzers. However, calibration difference among different instrument resulting in varied test results and requirement of high capital investments are expected to hinder the growth of market at certain extent. On the other hand, marginal distribution of these analyzers in the emerging economies can provide significant opportunities to the investors and manufacturers in terms of monetary benefits and geographic network expansion.
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1 Abbott2 Danaher3 F. Hoffmann-La-Roche Ltd.4 Meril Life Science Pvt. Ltd.,5 Siemens AG,6 Hologic, Inc.,7 Thermo Fisher Scientific, Inc.,8 Randox Laboratories Ltd.,9 Beckman Coulter, Inc.,10 Horiba, Ltd.
The global biochemistry analyzers market is segmented on the basis of type, modality, and end user. On the basis of type, the global biochemistry analyzers market is segmented into semi-automatic and fully automatic. Based on modality, the market is segmented into bench-top and floor-standing. On the basis of end user, the global biochemistry analyzers market is segmented into hospitals, diagnostic centers, pharmaceutical and biotechnology companies, research institutes, and contract research organizations.
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Experts Offer Advice on How to Handle Back-to-School Stress, Headaches, Migraines and More – Baptist Health South Florida
With the new school year comes plenty of stress and anxietyfor both students and parents. But this year, due to the coronavirus pandemicand the uncertainty of what to expect for the upcoming school year, students,parents and even teachers are experiencing higher than normal amounts of stressand anxiety.
In a recent Baptist Health Resource Live panel discussion, Easing Back-to-School Stress, Migraines & More, television host and journalist Jeannette Kaplun, who is also CEO of Hispana Global, was joined by Graciela Jimenez, a family psychologist with Baptist Health Care & Counseling, and Dalia Lorenzo, M.D., a neurologist with Miami Neuroscience Institute.
The two experts offered their thoughts on back-to-schoolstress and steps you can take to get your stress to a more manageable level forthe upcoming year. They also detailed what happens in your brain when youexperience stress and why it can sometimes lead to headaches or migraines.
If we didnt have a little stress, we wouldnt be able to function a little bit of stress is good for us, said Ms. Jimenez. Where it gets out of control is when you start getting headaches and other physiological responses to the stress.
With COVID-19, kids are feeling stress just like theirparents, they just dont have the emotional vocabulary or coping skills tomanage their stress. Dr. Jimenez advised looking for changes in your childsbehavior.
If they usually sleep through the night and have difficulty sleeping too much or too little or if their diet has changed, theyre eating more, or theyre more irritable, then, yes, you should seek out some assistance, said Ms. Jimenez.
Dr. Lorenzo attributed an increase in the number ofpatients presenting with headaches, migraines and insomnia to the coronaviruspandemic. Certainly, Im seeing a lot of patients coming in with worseningmigraines and new-onset headaches, said Dr. Lorenzo. Theres also a lot of depressionand isolation out there right now.
Asked by Ms. Kaplun what the difference is between aheadache and a migraine, Dr. Lorenzo responded, A headache can be caused bymany things eye strain from too much screen time or an old visionprescription; temporomandibular joint disorder (TMJ); a sinus problem; neckdisk disease, or just a standard tension headache. A migraine headache, on theother hand, is a primary neurologic disorder that affects the meninges, thefibrous membranes that cover the brain and spinal column.
Migraines can be triggered by any number of things,according to Dr. Lorenzo, from diet and sleep deprivation to uncertainty anddisruption of routines. But stress, she says, is one of the biggest triggers ofmigraines.
Other types of headaches, such as thunderclap headachesor those accompanied by fever, can indicate a serious medical condition andshould be immediately evaluated by a doctor.
Ms. Jimenez said that area residents who feel they or a loved one might benefit from mental health counseling but dont know where to turn can start by calling 211, a regional resource for references, referrals for counseling, group discussions and more. Or, ask your childs physician or teacher they have access to all sorts of resources.
For those who prefer a consultation from the comfort and safety of their own home, Ms. Jimenez recommended using a telehealth service such as Baptist Health Care On Demand, which offers online video consultations with licensed therapists.
Telehealth is great option for people of all ages from college students and parents of young kids, to working professionals, seniors, and anyone with chronic health issues that limits their ability to leave their home, Ms. Jimenez noted. The Care On Demand app is free, and you can receive $10 off your first consultation through Dec. 31, 2020 with code WELLBEING.
Tags: back-to-school stress, Baptist Health Care & Counseling, Dalia Lorenzo M.D., Graciela Jimenez, headaches, Jeannette Kaplun, kids and stress, Miami Neuroscience Institute, migraines
UNCP Patent to Aid in Alzheimer’s, Brain Injury – Southern Pines Pilot
The University of North Carolina at Pembroke has been awarded the first patent in the universitys history for a method to treat Alzheimers and traumatic brain injury patients.
The patent resulted from the work of Dr. Ben Bahr, William C. Friday Chair and Distinguished Professor, and his team at the UNCP Biotechnology Center. Recognized as one of the worlds leading experts on neurodegenerative diseases, Professor Bahr is listed as inventor on the patent.
This patent is yet another milestone that recognizes the cutting-edge research Dr. Bahr is conducting in his laboratory on these diseases that rob us of our very essence of who we are as people, said Chancellor Robin Gary Cummings.
This is transformative research with far reaching implications for the future relief of human suffering. UNCP is so proud to boast Dr. Bahr among its faculty.
Bahr previously discovered a compound that was shown to clear accumulations of protein material in the brain that cause memory loss and contribute to Alzheimers disease.
The patent covers previous compounds, new derivatives, and unique combinations that tap into the rapidly growing field of natural products for brain health. We are probably the first to show how you can combine them to be able to treat diseases such as Alzheimers, Huntingtons disease and ALS, said Bahr, professor of Molecular Biology and Biochemistry.
And very importantly, the U.S. Patent Office allowed us to include the treatment of mild cognitive impairment. The MCI disorder, which we tested in animal models, is often considered pre-Alzheimers disease and where you really want to start treating early dementia symptoms before Alzheimers disease slowly becomes established in the brain.
It is Bahrs hope UNCPs landmark patent will get the attention of pharmaceutical companies with regard to his efforts to slow and even reverse the progression of Alzheimers disease which affects nearly 6 million Americans. The research is also the focus of a Ph.D. project by Michael Almeida in Bahrs lab.
The new patent US 10,702,571 covers traumatic brain injuries since these types of injuries accumulate similar toxic protein deposits as Alzheimers. Bahrs research has led him to identify a unique class of cathepsin B-enhancing compounds, cathepsin B being an enzyme that can degrade and clear the nerve-damaging deposits found in both Alzheimers and TBI.
As it turns out, both football players and military individuals too often develop chronic traumatic encephalopathy (CTE) and that has the telltale images of the kind of protein deposits that occur in Alzheimers disease.
The patent also includes compounds from patents awarded to Bahr and another medicinal chemistry professor, Dr. Dennis Wright, while he was on the faculty at the University of Connecticut, prior to coming to UNCP in 2009.
He has presented his research in 17 countries and has over 150 publications on neuroprotection pathways and neurodegenerative diseases. Bahr is widely respected among his colleagues in the neuroscience field across the state and nation.
Dr. Todd Cohen, associate professor at the Neuroscience Center at the University of North Carolina at Chapel Hill, has interacted extensively with Bahr, exchanging reagents and brainstorming ideas.
I have been very impressed with Dr. Bahrs research program to advance therapeutics for diseases caused by the protein including traumatic brain injuries.
By improving the health of neurons, we may be able to improve synaptic function and restore cognition to those in the military that suffer from blast injuries, as well as other people that undergo single or multiple brain traumas since both conditions affect the tau protein that forms deposits in the brain. His teams work should provide major new insight into these conditions and help guide therapeutic development in the coming years to treat these patients with effective new drugs, Cohen said.
Dr. Ronny Bell, professor and chair of the Department of Public Health at East Carolina University, said the new patent is exciting news for UNCP and for Bahr.
Dr. Bahr is leading cutting-edge research in the field of cognitive decline and Alzheimers disease.
Current projections indicate that the number of Americans diagnosed with Alzheimers Disease will triple by 2050, so there is a tremendous need to advance the science to better understand this condition and develop effective prevention strategies. I applaud Dr. Bahr and his team for their outstanding work, Bell said.
Since joining UNCP in 2009, Bahr has received numerous prestigious accolades, including the 2013 Governor James E. Holshouser Award for Excellence in Public Service given by the UNC Board of Governors. He has also earned the Outstanding Mentor Award from the Council for Undergraduate Research, a testament to his passion for teaching the next generation of scientists and researchers.
Because of the contributions to his field, the UNC Board of Governors also presented Bahr with the 2017 O. Max Gardner Award, the highest honor a faculty member can receive from the UNC System.
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UNCP Patent to Aid in Alzheimer's, Brain Injury - Southern Pines Pilot
Rasha Kelej, the CEO of Merck Foundation Makes It to the List of 100 Most Influential African Women 2020 – Outlook India
(Eds: Disclaimer: The following press release comes to you under an arrangement with Business Wire India. PTI takes no editorial responsibility for the same.) Mumbai, Maharashtra, India & Accra, Ghana Business Wire India Merck Foundation CEO, Rasha Kelej, featured in the list of 100 Most Influential African Women 2020, by Avance Media as part of Be a Girl Initiative for her efforts to build health care capacity in Africa and to empower girls in education to help them reach their potential and pursue their dreams.Rasha Kelej, CEO of Merck Foundation and President, Merck More Than a Mother has been featured in the list of 100 Most Influential African Women 2020, released by Be a Girl Initiative, for the second time as she was selected to be One of Most Influential African Women by New African Magazine, UK, 2019.https://100women.avancemedia.org/2020-honourees/Rasha Kelej has been recognized for her efforts through Merck Foundation programs to train thousands of African doctors, to support African communities during Coronavirus lockdown and to empower girls in education so that they can reach their potential and pursue their dreams through Educating Linda program. This is for the second time, as she made the 100 Most Influential Africans (women and men) in 2019 by New African Magazine, UK, for empowering women in general and infertile women in particular through the Merck More Than a Mother campaign, which is a historic movement that aims to empower childless and infertile women through access to information, education, and change of mind-sets.Dr. Rasha Kelej is very well respected in the African Communities at all levels and this for her dedication and passion to unleash the potential of young Africans and her coherent strategy and implementation of serious programs that shape the Public healthcare landscape in Africa positively. More than a thousand young doctors from 35 countries have benefited from unique opportunities of specialty education in many fields such as diabetes, cardiovascular, endocrinology, sexual and reproductive medicines, respiratory, acute medicines, oncology, fertility, embryology, and scientific research.Expressing gratitude on the recognition, Dr. Rasha Kelej emphasized, I feel honored and proud to receive this recognition and to be included in this prestigious list among such renowned African women from all spheres of life. This is an important recognition not only for me but to Merck Foundation and our team. As an African and an Egyptian woman, I have a great passion for improving access to equitable and quality healthcare solutions for all Africans. I am very lucky to work as CEO of Merck Foundation as I am empowered by them to realize our unique vision through such successful pan African programs in partnership with African First Ladies, to contribute to the future of these girls as part of our signature campaign Merck More Than a Mother. I strongly believe that empowering women starts with education, to enable them to be healthier, stronger, and independent.This recognition will also encourage and motivate me to empower the talented girls of my beautiful continent. I promise to use my influence to support and empower women, support girl child education, and build healthcare capacity in Africa, Asia and beyond, added Dr. Rasha Kelej.The list has a representation of the most powerful African women from 34 countries, chosen from various career backgrounds including diplomacy, philanthropy, politics, activism, entrepreneurship, business leadership, and entertainment. It includes many famous names like; H. E. Monica Geingos, The First Lady of Namibia; H.E. Elene Sirleaf, Former President of Liberia, amongst others.Dr. Rasha Kelej, CEO of Merck Foundation and president of Merck More Than a Mother was recognized last year as one of most influential Africans in 2019 to acknowledge her efforts to empower infertile women through the historic campaign Merck More Than a Mother.She has been able to work in long term partnerships with 18 African First Ladies as Ambassadors of Merck More Than a Mother to build local healthcare capacity, empower girls in education and break infertility stigma across the continent. Rasha Kelej Facebook: https://www.facebook.com/KelejRasha/Rasha Kelej Twitter: http://www.twitter.com/rashakelejRasha Kelej Instagram: http://www.instagram.com/rasha_kelejFor more information on Merck Foundation, please visit: http://www.merck-foundation.comTo view the list of 100 Most Influential African Women 2020, please visit: https://100women.avancemedia.org/2020-honourees/To View the Image Click on the Link Below:Dr. Rasha Kelej, CEO of Merck Foundation & President, Merck More Than a Mother; One of 100 Most Influential Africans 2019 & 2020 PWRPWR Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: PTI More from Outlook Magazine
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Rasha Kelej, the CEO of Merck Foundation Makes It to the List of 100 Most Influential African Women 2020 - Outlook India
4-H Gives Incarcerated Youth Freedom to Try Their Hands at Growing Vegetables – AgNet West
Youth up to 17 years of age who have been arrested or adjudicated for breaking the law are housed at juvenile detention facilities. In Sonora, while the young people are being detained, the staff at Mother Lode Regional Juvenile Detention Facility strive to create a safe environment for the residents to make positive changes in their lives.
To teach the youths about the food system, JoLynn Miller, UC Cooperative Extensions 4-H youth development advisor for Tuolumne County, and volunteers began visiting weekly in 2016 to help the residents develop a garden at the detention facility. With grants from a local community group, the youths have learned how to grow their own vegetables and prepare them to eat.
The youth enjoy the educational aspect of the 4-H program and are excited whenever we harvest a new vegetable, Edgar Ortega, juvenile corrections officer, wrote in a letter. When the vegetables are ready, some of the youth along with the help and supervision of the staff make a new culinary experience for their peers.
Bonnie Plants donated tomato, garlic, fava bean, onion and basil seedlings.Miller trained volunteers who work with youth at the facility in the same positive youth-development concepts that 4-H volunteers use in 4-H club activities.
The youth planned and built the raised beds using power drills, Miller said, acknowledging that it is rare for power tools to be allowed for use by residents in a detention facility. They worked with the correctional officers to install drip irrigation in the garden.
At the end of last season, Miller gave the residents a cooking lesson using green tomatoes and basil from the garden. We made fried green tomatoes and pesto, she said.
We sincerely appreciate the efforts 4-H volunteers provide to enrich the lives of all youth in our community, said Dan Hawks, chief probation officer in Sonora.Not only do these projects provide real-world, hands-on instruction and skills to incarcerated youth, but it also provides them with an opportunity to reap the rewards of their own efforts.There is no lesson that can match the sense of accomplishment youth realize when they are able to harvest and consume crops they planted and tended themselves.
Lessons include mindfulness
In addition to teaching the residents gardening and cooking, Miller provided their teacher and staff with other 4-H curriculum, including mindfulness.
The mindfulness program helps the youth develop coping skills and become more cognitively aware of themselves and their surroundings, Ortega said in his letter. The youth are open-minded about the different techniques and lessons of the program and, at times, I catch them practicing the different mindfulness technique on their own. I know the mindfulness program is great for our youth because in their own home environments they dont always have a role model to teach them proper coping skills.
The garden wasnt an instant success. Using seeds Miller found in the UC Cooperative Extension office, their first lesson was persistence despite delayed satisfaction. We tried for two summers to grow in the garden beds and not even zucchini would grow. The placement was bad, she said. The plants needed more sun.
Community group funds garden
The 4-H advisor and the youths began seeking funding to buy supplies for the project. With some coaching from Miller, the youths applied for a grant from Farms of Tuolumne County, which advertised a total of $1,500 to be split between awardees.
The youth came up with a budget to build the beds of their dreams, but it was $2,200, Miller said. They asked for it anyway, knowing they may only get enough money to build one bed. Because residents are not allowed to leave the juvenile correctional facility, the Farms of Tuolumne County Board of Directors visited the facility to hear the teenagers present their vision for the garden project. Impressed, the board gave them the full $2,200 requested.
The Farms of Tuolumne County Board of Directors admires the enthusiasm of the young people who are part of this garden project, the dedication of the staff, and the hard work and commitment of JoLynn Miller, said Marian Zimmerly, FOTC chief financial officer. The board believes this project can be a positive influence on the young people who find themselves in the facility. FOTC is honored to lend its support.
Like many community groups, Farms of Tuolumne County is suffering financially during the coronavirus pandemic, yet approved another $750 for the garden and other 4-H agriculture projects at Mother Lode Regional Juvenile Detention Facility, saying, The FOTC Board of Directors continues to view the garden project at the Juvenile Detention Center as very worthy of support.
Participants appreciate lessons
The residents have expressed their appreciation to the 4-H program. Thx for everything you showed us, one resident wrote to Miller and her 4-H volunteers. Ive learned a lot since I first got here. I learned how to farm, make compose [sic] and a whole other bunch of stuff. I was never really interested in gardening until I came here. I really wanna learn more about gardening.
Despite the constraints caused by the pandemic, Miller plans to continue the 4-H partnership with Mother Lode Regional Juvenile Correctional Facility on the garden project and other agricultural educational activities.
As the pandemic began, Miller was given permission to use Zoom to deliver embryology lessons and science experiments using eggs. She is projected onto a big screen in a meeting room while the officer on duty walks around the room with an iPad, using its camera and microphone to connect her with the students at different tables doing experiments such as egg dissection and testing egg strength.
She was allowed to bring five-week-old chicks into the facility to let the youth see, touch and hold them as a capstone to the project. Miller plans to continue meeting with the youths via Zoom to discuss projects and drop off approved project supply kits for them to use.
Wed like to finalize a project we started last fall where we brought in baby goats, Miller said. Theyve since been harvested, and we want to have our UC Cooperative Extension nutrition, family, consumer sciences advisor Katie Johnson provide a nutrition lesson with the residents making goat tacos.
As time permits, officers take the youths outside to water plants and harvest crops in the garden.
4-H services are a priceless resource
I feel the programs and workshops provided by 4-H services are a priceless resource to the youth of our facility, wrote William Neilsen, senior juvenile corrections officer. It allows us to diversify programing and provide hands-on and -off educational opportunities within our facility that teach the youth about agricultural resources otherwise unavailable to the youth here. These programs inherently teach the youth responsibility and life skills and the youth gain a wealth of knowledge from these services.
Additionally, I strongly believe there is a therapeutic resource provided to staff and youth alike. As we progress forward, I am happy and excited in the continued partnership we have with the UCCE 4-H program of Tuolumne County.
Ortega added, 4-H provides the youth an opportunity to develop life skills that will transition to their own home environments.
By Pamela Kan-Rice
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Original post:
4-H Gives Incarcerated Youth Freedom to Try Their Hands at Growing Vegetables - AgNet West
Coronavirus’ Weird Trip Inside Cells Might Be Its Undoing, Scientists Say – HealthDay News
MONDAY, Aug. 24, 2020 (HealthDay News) -- The COVID-19 coronavirus uses an unusually complex method to replicate itself inside human cells, and experts say the somewhat clunky process could be exploited to stop the virus in its tracks.
All viruses hijack the biological processes of an infected cell to pull together the different proteins needed to make copies of themselves.
But the COVID-19 virus -- SARS-CoV-2 -- makes a stop along the way that's a head-scratcher for scientists.
It's widely known now that the virus infects cells using a spiky receptor "that is widely distributed to multiple tissue types," said Dr. Amesh Adalja, a senior scholar with the Johns Hopkins Center for Health Security in Baltimore. "This may explain its ability to impact multiple organ systems beyond the respiratory tract, to which other coronaviruses are largely restricted."
After infection, the coronavirus -- which is 1/100th the size of an average human cell -- uses two-thirds of its genetic material inside the cell to replicate. The hijacked cell reads the virus' genetic map and starts making the proteins needed to assemble new copies of SARS-CoV-2.
At this point, things get weird.
Instead of emerging straight from the cell's membrane, new SARS-CoV-2 viruses stop at a pancake-like structure inside the cell called the Golgi complex.
The Golgi complex acts as a kind of post office for the cell, sorting and processing proteins and sending them along to their final destination after encasing them in a protective coating called a vesicle.
SARS-CoV-2 viruses slip through the Golgi membrane, fully assembling there and using a piece of the membrane to form its protective outer envelope. The Golgi complex then encases each virus in a vesicle and ships it to the cell surface.
Thus, SARS-CoV-2 emerges from the cell as a fully complete virus, unlike other types of virus that assemble themselves as they emerge by stealing a piece of the cell membrane on the way out, said researcher Carolyn Machamer, a professor of cell biology at Johns Hopkins University School of Medicine.
"We're trying to understand the benefit for the virus, because it's a very inefficient way of getting out of the cell," she said. "Viruses are so streamlined, and they can mutate. If the process wasn't advantageous, the virus would be doing it a different way."
What makes this mystery harder to understand is that the Golgi complex is acidic, and potentially could damage the spiky proteins that the COVID-19 virus uses to infect healthy cells.
But the coronavirus appears to have figured out a way to neutralize the pH of the Golgi body so it can obtain its vesicle coating without damaging these spikes, the researchers said.
Ultimately, each infected cell can release millions of copies of a virus before the cell finally breaks down and dies.
These extra steps -- the trip through the Golgi complex and then emergence from the cell -- are promising targets for future drugs aimed at stopping the spread of COVID-19, Machamer said.
Current COVID-19 drugs like remdesivir work by blocking the replication process inside the cell, or help the body's organs and systems by reducing inflammation.
"We don't have anything for the later steps, where the virus assembles and then makes it way out of the cell," Machamer said.
Adalja agreed.
"Treatments for SARS-CoV-2 attack various points of the cycle it takes in entering and traversing cells, as do treatments for all viruses," he said.
These traits in SARS-CoV-2 replication have been seen in other viruses, but have come together in a unique way for the new coronavirus, researchers said.
Some viruses also use the Golgi complex in the assembly process, the most well-known being the German measles virus, rubella. Others like West Nile and hepatitis C emerge fully formed from the cell like SARS-CoV-2, but use a different method of assembly, Machamer said.
In this video, Johns Hopkins outlines the cellular processes involved:
More information
The U.S. Centers for Disease Control and Prevention has more about COVID-19.
SOURCES: Amesh Adalja, M.D., senior scholar, Johns Hopkins Center for Health Security; Carolyn Machamer, Ph.D., professor, cell biology, Johns Hopkins University School of Medicine
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Coronavirus' Weird Trip Inside Cells Might Be Its Undoing, Scientists Say - HealthDay News
New type of taste cell discovered in mice – UB News Center
Researchers Kathryn Medler (left), University at Buffalo associate professor of biological sciences, and Debarghya Dutta Banik, a UB PhD graduate who is now a postdoctoral fellow at the Indiana University School of Medicine, pictured in 2019 at UB. Credit: Douglas Levere / University at Buffalo
Multitasking taste cells can sense bitter, sweet, sour and umami stimuli, challenging scientists understanding of how taste buds work
Release Date: August 20, 2020
BUFFALO, N.Y. Some taste cells are multitaskers that can detect bitter, sweet, umami and sour stimuli, a new study finds.
The research challenges conventional notions of how taste works. In the past, it was thought that taste cells were highly selective, capable of discerning only one or two types of the five basic stimuli (only sweet, for instance, or only salty and sour). Though many cells are indeed specialists, the discovery of a subset of cells that can respond to up to four different tastes suggests that taste science is more complex than previously thought.
The study was published on Aug. 13 in the journal PLOS Genetics. The research was done on mice, which have a very similar taste system to humans, says Kathryn Medler, PhD, associate professor of biological sciences in the UB College of Arts and Sciences, who led the study with first author Debarghya Dutta Banik.
This changes the way weve been thinking about how taste cells function and how taste information is collected in a taste bud and sent back to the brain, Medler says. Our data fills in a lot of holes. Other research has suggested that taste cells can be broadly responsive, but we were able to isolate individual taste cells and describe how they work. I cannot definitively state that humans have these broadly responsively taste cells, but based on the high degree of similarity between the mouse and human taste systems, I predict that these cells are very likely present in humans.
Most taste cells selectively respond to a specific stimulus type while broadly responsive cells respond to multiple taste qualities. Credit: Jhanna Flora and Kathryn Medler
It is currently believed that taste cells are very specific about what stimuli they detect. The surprising thing with this new cell population is that individual cells can detect bitter, sweet, umami as well as sour stimuli, says Dutta Banik, PhD, a postdoctoral fellow in anatomy, cell biology and physiology in the Indiana University School of Medicine. Dutta Banik did the research while pursuing his doctorate at UB. It was surprising to know that individual taste cells can respond to so many taste qualities.
What happens when these multitasking cells are silenced?
Researchers Ann-Marie Torregrossa, University at Buffalo assistant professor of psychology, and Kathryn Medler, UB associate professor of biological sciences, pictured in 2019. Credit: Douglas Levere / University at Buffalo
Taste cells are critical to survival: They help us decide whether a food is a good source of nutrients or a potential poison.
Beyond identifying the multitasking taste cells, the new study describes some of their traits. Scientists showed that the cells detect sour stimuli using one signaling pathway, and sweet, bitter and umami stimuli using a different pathway.
Experiments also showed that when broadly responsive taste cells are silenced, mice have trouble tasting sweet, bitter and umami stimuli. This was the case even when the more selective taste cells those that specialize in detecting individual stimuli remained active, says study co-author Ann-Marie Torregrossa, PhD, assistant professor of psychology in the UB College of Arts and Sciences and associate director of the Center for Ingestive Behavior Research.
We did a series of taste tests, says Torregrossa, who led the behavioral aspects of the study. When the animals were missing the function of either the broadly responsive cells or of the traditional taste cells, they responded to sweet, bitter and umami solutions as if they were water. This is very exciting because it suggests they needed both cells to taste the solution normally. When we did the same taste tests with animals that had both cells, they as you would expect licked the sweet solution avidly and avoided the bitter.
Researcher Debarghya Dutta Banik works with an imaging system. In the new study, this set-up was used to locate taste cells through fluorescent microscopy. Dutta Banik, a postdoctoral fellow at the Indiana University School of Medicine, is pictured in 2019 at the University at Buffalo, where he completed his PhD. Credit: Douglas Levere / University at Buffalo
This shows that both of these cell populations are important for sending the taste information to the brain, Dutta Banik says.
The groundbreaking findings highlight how much scientists still have to learn about taste, including how taste buds work and send information to the brain.
Compared to other sensory systems, we know surprisingly little about how taste is coded and processed, Torregrossa says. This study identifies a new population of cells that are contributing to normal taste function, which could be a large piece in the puzzle.
The study's co-authors also included Eric D. Benfey, Amy R. Nelson, Zachary C. Ahart, Barrett T. Kemp and Bailey R. Kemp in the UB Department of Biological Sciences; and Laura E. Martin, Kristen E. Kay and Gregory C. Loney in the UB Department of Psychology. The research received support from the UB North Campus Imaging Facility, which is funded by the U.S. National Science Foundation.
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