Ai Weiwei’s new film goes behind the scenes of the Wuhan lockdown – DW (English)

After threeyears in Berlin, the Chinese artist Ai Weiwei now lives in Cambridgein the UK, but his latest film, Coronation, is set in the Chinese city of Wuhan as it undergoes a draconian lockdown due to the coronavirus outbreak.

Using footage filmed by citizens after the Chinese state locked down the city on January 23, Coronation observes the militarized and often brutal nature of the government-enforced quarantine until it was lifted in early April. It also reveals its efficiency in stopping the spread of the virus.

In an exclusive written interview with DW, Ai Weiwei shared his thoughtsabout the making of the film, and whether he believes the pandemic will fundamentally change society.

DW: What was your motivation for making Coronation?

Ai Weiwei: As with most of my activities, the motivation for making Coronation was to try and gain a deeper knowledge of a new and unfamiliar incident, such as with the Sichuan earthquake in 2008 and the refugee crisis in 2015. I wanted to provide a first-hand experience in understanding China and the Chinese people and how they responded to the coronavirus. Under these dramatic conditions, we can better understand the politics and humanity of any society.

Ai Weiwei: New film a window into understanding Chinese society

What was the biggest challenge directing a film from a remote location?

With today's technology, remote directing a film is possible. The biggest challenge for a director when approaching a subject is the concept.

Read more:Ai Weiwei's presents his 'Manifesto without Borders'

You can see in the film that young people, nurses and doctors and other health professionals came to Wuhan within days on buses. China is probably the only nation that could achieve that with such speed and spirit. You can see how the state built the infrastructure, including the emergency field hospitals, and equipped those on the frontlines with the necessary rescue equipment. Those details surprised me and are a profound revelation of human behavior under authoritarian control.

We also managed to show how they recruited those young people into the Communist party and the celebration after the lockdown was lifted. Those positive, objective parts about a very highly controlled authoritarian state are difficult to film.

You can see another person, a construction worker who came to Wuhan to assist the emergency effort, prevented from leaving the city. He attempts to navigate this typical Kafka-esque bureaucracy to get out. Unfortunately, we later learned Meng Liang managed to return home to be with his family, but he had financial issues and decided to hang himself. A tragic and banal story about life in these times.

How did you make sure your Chinese crews were safe?

I cannot make sure anyone is safe. I gave them daily instruction and they have the absolute choice to film the way they think is safe. They are all equipped with Personal Protective Equipment (PPE) and instructed on necessary medical protocols. Still, [it] could have been very damaging for the people filming. So we asked them to send out the material every day through the internet to protect those materials. We did not know what we had until we started to review and to edit. Most of the cameramen are amateurs, and this is their first time working on a film.

A still from 'Coronation': Wuhan's deserted train station

You have often critiqued China for its strict policies. What would be your critique at present?

China, as an authoritarian state, has been the most efficient in taking on a situation as challenging as a pandemic. In doing so, China's suppression of human rights, individual rights, privacy, and personal will has been heavy. Basically, China has consumed everyones liberty into its own power. That is the basic character of this nation's fast development and how it has closed the gap between itself and the West. It has worked very well over the last 30 years.

At the same time, China has created a society which has no trust, the controlling party has never gained legitimacy through the people's recognition but rather through police force, heavy propaganda, and by limiting balanced information. The Chinese state and its population do not trust each other but the state must be obeyed because maintains control through law and violence.

Instead of strictly cordoning off Wuhan, could there have been a more appropriate response to the initial coronavirus outbreak?

They made a good decision to seal off Wuhan. China has another 100 cities of similar size to Wuhan. If they [had not limited] the travel to and from the root city in this pandemic, we would [have seen] a true humanitarian disaster. At the same time, the method of sealing the city should not have been through literally sealing off people's doors, placing people in detention, or hiding the truth about the situation. This has caused a great panic.

Read more:'Wuhan Diary': 60 days in a locked-down city

Before the authorities sealed off Wuhan on January 23, there was a month or two when they knew the coronavirus was human-to-human transmissible. They covered up the number of infected and the death toll.

Do you think that societies will be forever changed due to the pandemic?

I am very pessimistic about what we will learn from this. I think that things will return to normal, people will simply take off their masks and throw them away into the rubbish bin. I don't think people will learn that much in general. Even if they have learned something, it will be superficial, like what has happened in China.

This interview has been edited for length and clarity.

Chairman Mao died in 1976. His death also marked the end of the Cultural Revolution. In the mid-1980s, modern artists started experimenting with the figure of Mao in their imagery - which at that time was still associated with considerable risks. Inspired by Andy Warhol's work, Ai Weiwei approached China's difficult relationship with Mao, the icon of the Cultural Revolution, in his "Mao Images."

Geng Jianyi (born 1962) was one of the big avant-garde names in China's modern art scene. He was part of one of the 179 artists' groups that formed during the 1980s. For his thesis, he painted not this but another couple, but the painting was rejected as being too "cold," as it did not correspond to the positive image of the socialist person that the regime wanted to perpetuate. Geng died in 2017.

Wang Guangyi (born 1957), was part of the "Group of the North" in the late 1980s, a group that focused extensively on Western philosophy writings. With his skilful combination of propaganda art from the Cultural Revolution with Pop Art aesthetics, his works became known as "Political Pop". "Great Criticism" is his best-known and -paradoxically - most commercially successful series.

Yue Minjun (born 1962) is also considered as a leader in China's avant-garde movement. He has long become one of those Chinese stars featured at international auctions. One can recognize his own facial features in his signature laughing grimaces. After the events on Tiananmen Square in Beijing in 1989, his "Cynical Realism" approach helped shape the direction of the socio-critical artist movement.

Born in 1963, painter and woodcutter Fang Lijun was featured at the groundbreaking exhibition "China Avant-Garde" in Beijing in 1989. He later developed his trademark style with his bald men against the backdrop of the sea or the sky. His imagery became the epitome of a new awakening in Chinese art. His works show people looking bored and angry at the same time - a reflection on Chinese society.

"The Great Chairman" shakes hands with his doppelganger in this work by Feng Mengbo. Feng was born in Beijing in 1966, when the Cultural Revolution started. Even as a student, the video and installation artist used his imagery to deal in a subversive manner with China's revolutionary idol. Feng has continued to recycle images from the Mao era in his videos and animations.

Zeng Fanzhis' painting "The Last Supper" measures four meters in width and has fetched a record sum of $23.3 million at an auction for Asian art in Hong Kong in 2013. In Zeng's work, which is modeled after Leonardo da Vinci's masterpiece, Jesus' disciples have all been replaced with pioneers wearing red scarves. Only "Judas" is seen wear a western tie - a reference to China's turn to capitalism.

Cao Fei is one of China's most recognized media artists, who is always represented in important international exhibitions on Chinese art. Her works often present a subjective mixture of fiction and documentation. This is how she addresses the fast pace of urban life in China, while also highlighting the impact of the latest technologies on people as well as their social consequences.

Huang Yongping (born 1954), is one of the earliest artists of the Chinese avant-garde. In 1986, he co-founded the group "Xiamen Dada", whose members were known for publicly burning their paintings after exhibitions. In 1989, he was one of the first Chinese artists to take part in an art show in France at the Centre Pompidou. After June 4, 1989, he stayed in Paris, where he still lives to this day.

Wang Renzheng a.k.a. "Nut Brother" spent 100 days in Beijing in 2015 to collect the smog-related dust particles from the air using an industrial vacuum cleaner. The artist from Shenzhen later mixed the particles with clay and baked this mixtures in a factory to form bricks. Air pollution at your fingertips - that is his commentary on the relationship between man and nature.

Author: Sabine Peschel (ss)

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Ai Weiwei's new film goes behind the scenes of the Wuhan lockdown - DW (English)

Peninsula Delivers a Heist Film in the Train to Busan Universe – Film School Rejects

Filmmakers have one very important choice to make before moving forward on a sequel to a popular movie. Do you go with more of the same and what clearly already worked? Or do you take a chance and try something new? Films have found success on both paths, so theres no right or wrong answer here necessarily, but not every film can swing both. 2016s terrifically intense and heartfelt Train to Busan is a rarity in that its received two follow-ups, both of which are entirely different creations. While Seoul Station (2016) is an animated prequel, Peninsula is a new live-action story set in the same world that too often feels like every other post-apocalyptic zombie thriller.

Captain Jung-seok (Gang Dong-won) sees the zombie plague growing and works to evacuate family members from the city before its overrun, but his efforts run afoul of human behavior. Four years later, still grieving his loss and feeling guilty over his failure, he heads back into South Korea on a mission to retrieve millions in U.S. cash. He and the team are successful, but their extraction doesnt go nearly as smoothly. Jung-seok finds himself in league with two industrious young sisters (Lee Re, Lee Ye-won) and their equally capable mother (Lee Jung-hyun), and soon hes once again trying desperately to escape the city.

Director/co-writer Yeon Sang-ho returns with Peninsula, but rather than deliver a direct sequel or more of the same he instead aims for a different kind of familiar. The film forgoes much of what makes Train to Busan so intensely affecting in favor of a somewhat more generic setting the world is populated by pockets of survivors, the city is filled with zombie hordes, and the most dangerous villains remain the living. Where the last film found terror and emotion by unleashing the undead into an otherwise normal day recognizable to us all, Peninsula drops viewers alongside new characters into the overly familiar sci-fi setting of a post-apocalyptic landscape.

By definition, this means more CG as well, and thats just one more layer of disillusionment between viewers and the unfolding action. Driving scenes, of which there are several, are a mix of CG and rear projection, and zombie masses are equally artificial. The result is a series of zombie attacks and action beats that lack the immediacy and terror of its predecessor. Add in a muted color palette and emotional beats that range from lackluster to exaggerated, and Peninsula is an undeniably lesser experience than Train to Busan.

Of course, all of that said, its a fantastic idea blending a zombie movie with a heist film, and Yeon has fun with the concept. The sub-genre has been stale for a long time, and injecting it with a bit of a Fast & Furious vibe is an entertaining move. The film feels bigger too, from its English-speaking news broadcast at the start (complete with the requisite terrible acting from Westerners) to its slightly more international vibe moving from Korea to Hong Kong and back to Korea again. The script layers the heist element with difficulty and double-crosses, and while most of it is visible well in advance Yeon still crafts the beats with style and energy. Vehicular shenanigans, gun fights, and last-second reprieves fill the time with a balance of high-stakes drama and silliness.

Train to Busan succeeds in part because of the emotional investment it encourages in its characters, and while Peninsula cant compete to the same degree the characters are still engaging. The emotional interactions are frequently heightened to exaggerated degrees, particularly in the third act, but its a silliness that works for the antics at hand. The sisters, in particular, are capably plucky and given plenty of action beats of their own. The desire to deliver fun and thrills leaves the film feeling less threatening, but the two young actors are are unavoidably affecting. The adults are a mix of familiar post-apocalyptic character types, but heroes and villains (Koo Kyo-hwan, Kim Min-jae) alike tear through the CG-afflicted landscapes with enjoyable abandon.

Peninsula is an energetic and entertaining ride through an urban landscape littered with both the skeletal remains of civilization and the cliches of the subgenre. What it lacks in originality, though, it makes up for with competency and enthusiasm as Yeon has fun riffing in a world of his own creation. Sure weve seen villains feeding other humans to zombies for sport, but here the undead come crawling out en masse in creepy as hell fashion youve seen it before but never quite like this.

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Peninsula Delivers a Heist Film in the Train to Busan Universe - Film School Rejects

Iroquois prophecies warn of grave dangers – Turtle Island News

By Doug George-Kanentiio: On Prophecy and the Enlightened Ones Across the broad band of the human experience we have looked to philosophers, seers, psychics and prophets to give us insights into our place within the universe and to provide us with direction as to events which lay before us. Prophets (Enlightened Teachers: Raonkwe:ta:shon:a in Mohawk) in particular believe they have been selected to carry out specific tasks from the Divine, that they have a unique personal experience with a spiritual entity which delivers to them, in a state of urgency, revelations about future events which are, in turn, based on moral teachings meant to direct, condition, exclude or advocate human behavior. Generally, prophets are exclusive since other spiritual practices are either condemned or re-defined; social changes are enacted towards a

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Iroquois prophecies warn of grave dangers - Turtle Island News

Why Sign The Duke Compact? | Duke Today – Duke Today

Duke started this semester with a campus safety plan that relies heavily on wearing masks, washing hands, physical distancing, robust testing and signing the Duke Compact.

The first four have a lot of science behind them. But what about signing the Duke Compact? What good does that do?

It turns out even the Duke Compact has research backing it. Let Dan Ariely explain.

The university professor and behavioral economist has made a career of studying how incentives (and disincentives) affect human behavior. He sees several reasons shown in research as to why the Duke Compact may make the campus safer.

One, when we sign something, we read it more carefully, Ariely says. Signing makes us more committed to following it. In pre-Corona times, when we agreed to something, we shook hands. When you shake hands, you take the agreement more seriously. The same with signing.

Finally, weve shown that signing a statement gets people to be more honest and they adhere more to what they sign.

Now, theres a caveat, Ariely says. Signing a document doesnt magically mean our misbehaviors go away.

But will it help? Absolutely. In fact, we should sign it again time to time to refresh our memory and commitment. This would remind us that there are a few important standards of behavior that we should all take to reduce the risk of COVID-19. After all, COVID-19 isnt just about us, its also about helping others and helping the entire community.

The Duke Compact was distributed to 45,000 university faculty, staff and students. As of Aug. 18, about 95 percent of undergraduate students have signed it, and 80 percent of graduate and professional students have signed. Nearly 19,000 faculty and staff have signed the compact, including 1,100 faculty who committed to teach in-person classes this semester. Overall, about 34,000 people around 75 percent -- have signed the Compact. Of the remaining 11,000, many of these are seasonal staff, retirees and other affiliates who are not routinely on campus.

Leigh Goller, Chief Audit, Risk and Compliance Officer at Duke, has received hundreds of questions university from community members about the Compact. Some express resistance, but most simply arent sure about certain points. The Compacts website provides answers for many frequently asked questions.

Here are some of the most common questions and concerns raised about the Compact.

Signing the Duke Compact is a condition of maintaining access privileges for university facilities on and off campus. Employees who choose not to sign can continue to work remotely, Goller said; however, if its not possible to do the job remotely, it may affect employment status.

The goal of the Compact is to help our community stay healthy and reminds us of our responsibility to keep those around us healthy classmates, colleagues, family and friends, Goller said. Its meant to inspire us to make a personal commitment to do the things we need to do to support a wider Duke community. This is to ensure everyone working and learning in the university setting has affirmed their commitment to practice the safety principles that will enable us to be in close proximity with one another. Part of that is understanding that everything you do when you are not on campus, you carry back with you if you come to campus.

The Compact follows employment status: It is required of university employees but doesnt apply to the Duke University Health System, which has its own guidelines for pandemic safety. This has created some confusion for faculty and staff in the two health schools -- medicine and nursing -- because although they are university employees, many spend much of their time in working with health system colleagues.

University leadership extended the Compact to them because they wanted the entire university community committing to the same set of behaviors, Goller said. This is an experiment on how to have a trusted and common set of behaviors among all people on campus, she said. All faculty, staff and students coming to campus are riding the same buses and walking the same sidewalks and occupying facilities together.

Weve had questions as to whether an employee can go visit family members or attend a wedding, Goller said. Duke has restricted non-essential university-funded travel. Duke is not telling you cant take a personal trip; thats your call.

If you do travel or attend an event, you should monitor your symptoms and use the SymMon app to help decide whether you need to come into campus. If you are traveling to a hot spot, we may ask you to follow Employee Health or Student Health guidance to stay at home for a few days before returning to campus, Goller said.

The state of North Carolina and City of Durham currently restricts most gatherings of more than 25 people, and Duke restricts most gatherings of more than 10.

Local and state ordinances differ. based on local conditions. As a porous campus, Goller said, Duke officials hope that everyone will be attentive to that guidance while off campus and to Duke's guidance while on it. As with personal travel, Duke may ask you to follow Employee Health or Student Health guidance to stay at home for a few days before returning to campus.

The university will accept certain religious and medical exemptions for taking the flu vaccine. But outside of those cases, getting a flu vaccine is part of the behaviors that will go a long way to maintaining community health this winter.

Dr. Cameron Wolfe, one of Dukes leading experts on infectious diseases, said no patient wants to get a double hit from the flu and from COVID. And unfortunately, it looks like both are going to be around this winter.

We need to do all we can to not let the two co-circulate, Wolfe said. The challenges of co-circulation of influenza and COVID-19 on a campus are not insignificant -- for many, the illness is similar. It would be clinically indistinguishable for me to separate them in front of a patient. Yet the management is quite different especially for people who develop severe illness. The extra PPE; the extra resource utilization; additional testing; challenges with quarantine requirements when you're not sure which virus you're dealing with.

I'm hopeful the masking and social distancing, and de-densifying that's occurred throughout the university will also help reduce flu. But we have an instrument, in a flu vaccine, that is recommended for almost every adult. This is the year, more than ever, if we're going to go to great lengths to keep our campus virus free, that means both.

Thats what Duke President Vincent Price and other university leaders had in mind when the Compact was presented. It was written following extensive collaboration with faculty, staff and students across the university, whose advice significantly shaped the final version. What didnt change was a core message about our responsibility to community health.

When it comes to COVID, we can behave in a way that contributes to the health and safety of others or we can behave in a way that frankly endangers others, Price said during a Leadership Conversation this past week. We needed to articulate that in a clear way, and the Duke Compact came out of that need. It is a collective statement about the basic things that each of us have to do to serve and support each other.

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Why Sign The Duke Compact? | Duke Today - Duke Today

Living on Less, Liking it More – mySteinbach.ca

Already back in 1976, Maxine Hancock wrote a book entitled, Living on Less and Liking it More. She eloquently made the case that the quality of ones life is not dependent upon acquiring more stuff, but rather in modest living, sharing good things and looking out for one another.

That same year, Gary Becker published The Economic Approach to Human Behavior. In his book he sought to prove that all human behavior is guided by the same self-centered greed that underlies economic capitalism. For this discovery, Becker received the Nobel Prize in Economics in 1992. In other words, the brightest minds on the planet agreed that selfishness is what makes the world go round. That people only practice generosity if that somehow serves their self-interest.

I think Becker has had more influence on how people live today than has Hancock. And the consequences are stark: Greater degrees of injustice. Deterioration in political discourse and stability. More unhappiness. And a huge strain on environmental integrity.

But the good news is that many studies since 1976 have proven Hancock to be at least as realistic about human nature and potential as Becker. Although the degree of cooperation varies widely, all the studies show that in no cultures do people behave 100 percent selfishly. And, furthermore, studies in neuroscience have proven that humans have in-built desires for altruism and fairness as well as selfishness and avarice. Different areas of the brain light up when in the process of grasping for ones self or sharing with others.

From a faith perspective, it is right after all then, to assert that all humans carry the image of God within them. Another way of saying it is that underneath the veneer of selfishness we have come to expect from one another, there lies a more cooperative spirit than we had thought. We have all experienced how such virtue surfaces in the context of emergencies like natural disasters.

This brings me to my point about downsizing for resilience. One way to tackle the ecological crisis facing our planet is to look for alternative sources of energy and materials to satisfy our needs at present levels of consumption. Another is to downsize our expectations on a broad front. And in order to accomplish this we can appeal to those deeper levels of altruism and fairness in people that often lie hidden behind a faade of selfishness and greed we have come to expect.

If those of us in the overprivileged world begin to understand the human and environmental holocaust that is unfolding around the world we can find it in our hearts to downsize for the sake of a little more justice, peace and environmental protection. Downsizing will not look the same for everyone. But if we are serious about it, we can find ways to downsize our homes, travel plans and our need for ever-more stuff. And in the process we will discover that we can live on less and like it more.

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How can humankind find a sustainable future in the midst of climate change? This scientist has some ideas. – Anchorage Daily News

Grassroots Stewardship: Sustainability Within Our Reach

By F Stuart Chapin III. Oxford University Press, 2020. 222 pages. $38.50 hardcover, $19.19 E-book.

Grassroots Stewardship: Sustainability Within Our Reach, by F Stuart Chapin III

F Stuart Terry Chapin, emeritus professor of ecology from the University of Alaska Fairbanks, has been a leading figure in scientific circles for decades as the author of hundreds of scientific papers and texts in ecosystem ecology and stewardship and as a participant in international fora. In 2019 he won the Volvo Environment Prize, one of the scientific worlds most respected environmental prizes, for his work in earth stewardship.

Now, Chapins years of research, learning and hard thinking about the relationship between people and nature has culminated in an optimistic argument for a grassroots movement leading away from the Earths destruction to sustainability. Grassroots Stewardship: Sustainability Within Our Reach marries science and ethics in a way that recognizes what ecology itself teaches everything connects. Although this is not a work directly about climate change, that issue, about which Chapin is intimately informed, underlies much of the discussion. The question that keeps him awake at night, he says, is how can global society shape our planets future so that our grandchildren and their grandchildren can thrive?

Scientists are trained to deal with data and objectivity and are notoriously poor at communicating with the general public. Happily, Chapin commands an ability to explain science in ways that ordinary people can not only understand but will find interesting and relevant to their lives. He understands that storytelling is at the heart of communicating. He admits midway through the book, Ive only recently come to appreciate the power of stories in setting the stage for effective dialogue about societal and environmental issues. I should have made this connection long ago. Just as his grandchildren beg him for stories, not facts, audiences of all kinds look for stories from scientists that, while consistent with facts, are about people and events.

Indeed, a reader of Grassroots Stewardship is unlikely to remember what climate models tell us about the expected global warming by 2100 (2.5 to 8 degrees F. higher than today) while easily recalling stories of Newtok, Alaska, losing ground to permafrost thaw and erosion, of Miami, Floridas frequent flooding, and Capetown, South Africas water emergency in 2018. Chapin includes personal stories from his boyhood, such as bodysurfing on the Carolina coast, and from his life of travel and research. He tells of wandering through Stockholms allotment gardens, where citizens tend urban gardens that connect them to nature and community and help with food security and resilience. He tells numerous stories of time spent in Alaska Native communities and what he learned about respect for the land and what it provides.

While the author initially details some of the challenges facing humankind and the worlds ecosystems, the emphasis throughout is on how we might, starting as individuals, move forward into sustainable practices and an ecological model of living. Chapins four-tiered stewardship strategy is about solutions. The four tiers are individual actions, effective communications built on trust, collaborating on shared goals, and political action.

Each chapter lays out an issue or approach and ends with a What can we do? section of bulleted, practical acts. For example, the chapter on individual actions discusses attachment to place, cities that have reinvented themselves, patterns of consumption, and the kinds of trade-offs that can be made to better the environment and human health. This is followed by a list of starting points that include experiencing nature, understanding how consumptive choices affect nature, and modeling good behavior regarding consumption.

While the suggested actions throughout emphasize grassroots that is, individuals and like-minded people who join together Chapin is clear that theres a chain of influence, from making personal earth-friendly choices, being informed, talking with people on all sides of an issue, collaborating and compromising, and eventually directing government policies and enacting laws. The book was finalized just as the coronavirus pandemic began upending lives, but it recognizes that even before that we were caught up in a world of great economic disparity, inequality and political divisiveness. Chapin emphasizes again and again the necessity of holding honest and respectful discussions with those outside our own circles, to find ways we can move forward together.

Is the author a Pollyanna, too optimistic about human behavior and possibilities for derailing the coming cataclysm? We might ask this. But we might also ask, why cant Chapins vision, his four-tiered strategy, be realized? Everything he suggests from adopting new technologies to educating women to protecting forests and wetlands to reducing population growth and consuming less is doable, if humankind can only agree on some fundamental shifts. Continuing business as usual is not an option, if we want future generations to inherit a livable world.

Grassroots Stewardship will likely be adopted for use in classes on stewardship and sustainability, but its readability and applicability to the lives of ordinary citizens should put it on reading lists more broadly. Photos, diagrams, and charts enhance the text. Back-of-the-book materials, besides notes and an index, include a useful glossary and a list of climate-action guides.

[Because of a high volume of comments requiring moderation, we are temporarily disabling comments on many of our articles so editors can focus on the coronavirus crisis and other coverage. We invite you to write a letter to the editor or reach out directly if youd like to communicate with us about a particular article. Thanks.]

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How can humankind find a sustainable future in the midst of climate change? This scientist has some ideas. - Anchorage Daily News

How Smooth Muscle Cells in the Human Airway Behave To Trigger Asthma – Technology Networks

These days, novel diseases such as COVID-19 are pushing scientists to work real hard and real fast to find treatments and cures for patients.

But there are also many other types of old foes that live within usdiseases that have been part of our lives for such a long time that we can easily forget how much (or little) we know about them and their causes.

Asthma is one of these diseases, and it affects millions and millions of people around the world.

Scientists think that asthma results from the behavior of unhealthy cells within the human airway. But now, researchers at Northeastern have found that the way those cells trigger asthmatic attacks isnt only a result of how they communicate with one another.

Rather, that behavior is also a result of the interactions of airway cells with a mesh of important proteins and molecules known as the extracellular matrix, which isnt part of the cells but serves as a structural and biochemical support for them.

The new findings show how even healthy human airway cells in contact with each other can respond to a stimulus in a similar way as the unhealthy cells from an asthmatic personthat is, if they are also in contact with an unhealthy extracellular matrix.

We have known for decades that there are pathological changes to the extracellular matrix, says Harikrishnan Parameswaran, an assistant professor of bioengineering who led the study. But its functional consequence in asthma was not known.

During an asthma attack, the cells in someones airway react to different substances and constrict, or stiffen. That swelling affects the capability of the airway to supply air to the lungs.

Because that reaction occurs when those cells receive a very small dose of the substance that causes such physiological response, conventional research to tackle asthma has largely focused on it as a disease of those particular cells.

The new findings, however, show that asthma is not entirely a disease of those cells. Instead, Parameswaran says, it could be a result from a situation in which healthy cells find themselves in a bad extracellular environment.

Thats because as the disease progresses over time, the properties of the material outside the cells, as well as its influence on them, can also change.

This gives you a mechanism by which this extracellular matrix remodeling actually impacts constriction, Parameswaran says.

Research into better treatments for asthmatic people normally focuses on the pathology of the cells, and leaves the matrix outside of the equation.

Scientists have generally focused on the collective behavior of the kinds of cells that line the airway, known as smooth muscle cells. These types of cells coordinate different kinds of involuntary stretching and squeezing in various parts of our insides, including the gut, uterus, and other hollow organs.

Many of our cells use small openings within them, known as gap junctions, for intracellular communication. Those openings work like tunnels of a highway system that create communication networks. Through those gaps, cells can talk to each other, and send the various types of signaling molecules that trigger the physiological machinations that orchestrate simple and complex bodily functions.

Cells are known to use calcium waves extensively to communicate with one another through gap junctions. But even after disassembling those gaps, Parameswarans team didnt see a change in the way calcium propagated along the muscle.

On those extracellular layers, cells responded differently to the stimulus when they were together than when they were apart. And their mechanical communication responded as if they had received a very strong dose of histamine, even though they did not.

That observation told Parameswarans team that the airway cells do not rely on gap junctions. Instead, he says, the stiffening of the extracellular matrix appears to connect them and create the collective action that triggers the stiffening in response.

Parameswaran says he believes asthma persists because of the molecular changes within the matrix that scientists havent targeted extensively.

Thats why, he says, in the specific case of the human airway, the discovery means that researchers might need to start developing therapies that can target stiffening of the extracellular matrix in the airway to treat asthma.

There is no cure for asthma, Parameswaran says. Because we have specific evidence that pathological stiffening in the extracellular environment is sufficient to cause hyper-constriction, it is imperative now to see if we can target matrix stiffening as a therapy.

Those findings fit within an active area of research in biophysics that explores how cells use more than just gap junctions to trigger collective actions within the body. The discovery of how they coordinate collective behavior in the airway is something that scientists have previously not been able to see, says Erin Cram, a professor of biology who co-led the new study.

These cells respond differently as a collective than they do as individuals, Cram says. Its kind of like a mob that responds differently to a stimulus than four or five individuals spread out over a field.

In the long run, unveiling ways of intercellular communication like that could also help other scientists understand how smooth muscles in the airway and other organs interact with the rest of the biochemistry of the body, says Cram, whose lab studies the reproductive system of Caenorhabditis elegans, a microscopic worm with cells that behave in similar ways to human smooth muscle cells.

If you think about the cells of your airway, theyre all interacting together, she says. You dont have a cell here and a cell therethe whole thing is lined with cells. This is a much more realistic picture of whats probably actually going on.

Reference:Stasiak, S. E., Jamieson, R. R., Bouffard, J., Cram, E. J., & Parameswaran, H. (2020). Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells. Science Advances, 6(32). doi:10.1126/sciadv.aba1149

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Visualizing Data To Save Lives: A History of Early Public Health Infographics – The MIT Press Reader

A wave of statistical enthusiasm, coupled with new technologies, paved the way for data visualization that laid the foundations for social reform in 19th-century Britain.

By: Murray Dick

When publicized far and wide enough, infographics, some experts argue, can save lives.

The communicative value in visualizing data toward improving public health outcomes is long-established, going back over two centuries. And while the earliest examples were intended to inform discussion and debate among an elite social sphere, they also sought to address real-world problems.

From 1820 to 1830, an enthusiasm for statistics began to emerge across the western world, leading to an era of statistics concerned with reform. It was led by individuals who sought to disrupt what they saw as the chaos of politics and replace it with a new apolitical regime of empirical, observed fact. This new approach would come to be seen as a field of action, as an applied science, providing empirical weight to the new, intellectually dominant spirit of political economy.

Following the creation of the General Register Office (GRO) in 1837, the first wave of statistical enthusiasm was applied to poverty and to the lived environment of the poor; the progressives who undertook these surveys did so in the legal context of the reforming acts of the early 1830s. Separate from (but at the same time, often socially or professionally connected to) the governments of this era, a network of liberal-minded, reforming individuals hailing from business and professional classes busied themselves in statistical pursuits. Within a few years, in the capital and in the major cities of the industrial north, a series of societies was founded, each bearing the imprint of their own members interests and concerns.

Health matters tended to dominate the concerns of the societies in part because health represented a fundamental component of the well-being of the working classes, as medical historian John Eyler writes in his book Victorian Social Medicine; but also because data were comparatively easy to produce.

The emergence of these new societies coincided, in the 1840s, with a wider publishing revolution; new communications and printing technologies were making possible both increasingly affordable and improved-quality print publications, paving the way for early public health visualizations.

Health matters tended to dominate the concerns of the societies in part because health represented a fundamental component of the well-being of the working classes.

William Farr, regarded as one of the founders of medical statistics and epidemiology, started his career in medical journalism rather than in practice, which in turn helped him cement his reputation as an expert on vital statistics. In 1839 Farr joined the Statistical Society of London, remaining a core member until his retirement. A regular contributor to one of the worlds oldest medical journals, The Lancet, Farr combined sympathies for liberal reform with the demeanor of the professional statistician. Like many of his peers in the statistical societies of this era, he struggled to balance an ideological inclination toward self-help, with statistical findings that mitigated state intervention.

The GROs policies under Farr were anti-contagionist (in terms of medical outlook), and environmentalist (in terms of reform), writes the late sociologist and historian of science Alain Desrosires. Farr used graphics in his publications for the GRO, some of which, though certainly not innovative, had a striking impact. For example, in his summary report, published in the Fifth Annual Report (1843), three line graphs are used to juxtapose mortality rates between Surrey, Liverpool, and an average Metropolis, demonstrating wide variation in the laws of mortality across the distributions. The middle of these three charts, representing Liverpool, showed that half the children there died before the age of six challenging previously held convictions of the time that the rapid growth of the city was proof that its environmental climate was healthy.

Another medical journalist who experimented with data visualization, John Snow, started his trade in London during the mid-1830s, having several papers published in The Lancet and the London Medical Gazette. On the Mode of Transmission of Cholera (1849) was published in the same year that Snow published articles about cholera in the Medical Gazette and Times. He proposed that the disease was carried in water supplies contaminated with diarrhea and that it passed via human contact and through contact with contaminated matter.

In his statistical maps, he used GRO data reports Weekly Return of Births and Deaths in London to map local incidences of the disease and to compare them with previous outbreaks. The centrality of Snows findings to medical cartography, geography, and epidemiology are long established in the literature but a question remains as to why he failed to convince his contemporaries of the logical conclusion of his findings. Tom Koch, a clinical ethicist and the author of Cartographies of Disease, suggests Snow did not put forward a compelling general theory to substantiate his local findings he refused to challenge the zymotic theory (the belief that infection was exclusively a consequence of airborne vapors), a theory promoted in the writings, diagrams, and maps of, among others, William Farr.

Through family ties, Florence Nightingale, a trailblazing statistician, social reformer, and nursing pioneer, became acquainted with many of the leading medical figures of the day, including Farr. Nightingale and Farr developed a mutually advantageous relationship based on shared goals, at least initially, in which he provided her with statistical advice, while she provided him with access to her politically influential contacts. When the Crimean War broke out in September 1854, The Timess William Howard Russell sent back a series of damning reports from the front, causing great disquiet among its readers and the wider public, raising awareness of the armys lack of preparedness, and poor medical management of the wounded. War Secretary Sidney Herbert was compelled to act, asking Nightingale to visit the army hospitals, in the Crimea, at government expense.

Just as Nightingales presence at Scutari Barracks hospital, Istanbul, had been precipitated by the press, so too her reputation was cultivated, as a consequence of favorable coverage in The Times that popularized her persona as The Lady with the Lamp who spent much of her time doting on convalescing soldiers. Although taking up what was primarily an administrative role, Nightingale paid regular visits to the wards, developing a strong affection among the soldiers, leading to her symbolic association with maternal caring.

For Nightingale, disease was a quality of the human condition, not something that may be isolated and treated in a particular context.

After the war, in September 1856, Nightingale was invited to Balmoral to discuss her experiences and thoughts with Queen Victoria and Prince Albert, leading a few days later to an interview with Lord Panmure, who agreed to the setting up of a commission to investigate the shortcomings of the armys medical infrastructure.

Nightingales Notes on Matters Affecting the Health, Efficiency, and Hospital Administration of the British Army (1858) was damning in its conclusions about the consequences of the deleterious sanitary conditions in the army hospitals of the Crimea; deaths from (mostly) preventable disease outnumbered deaths on the battlefield (or injuries accrued on the battlefield) by a factor of seven to one. For Nightingale, disease was a quality of the human condition, not something that may be isolated and treated in a particular context.

Nightingale had a natural flair for infographic design, or statistical aesthetics, to quote John Eyler, which she used to accentuate her work. She was as attuned to the persuasive power of data visualization as she was in her use of written rhetorical techniques. She thought her graphical forms had the power to speak both to the public and to the Queen; however, these forms were not discursively addressed to a wide-ranging, reading public indeed some were only published, if at all, buried away in the appendixes of several-hundred-page-long government reports.

In March 1858, Nightingale developed a sophisticated media campaign, in order to maintain the political momentum of the commissions findings and to ensure its recommendations were carried out. She identified a number of editors who could be enlisted in getting her message across, supplying their names to the commissioner (and close personal friend) Sydney Herbert. She focused her efforts on the heavies the quarterlies and reviews whose editors garnered a higher degree of respect in polite society than any daily newspaper editor of the day could realistically hope for. Nightingale put together individualized press packs for each one of these contacts, comprising outlines, the facts, even the headings for all articles; though all were to be published anonymously.

Both Nightingale and Farr were concerned in their statistical investigations with uncovering natural laws about human behavior. If man could discover these laws, they reasoned, he might adapt society accordingly, in an act of progressive improvement.

Both Nightingale and Farr were concerned in their statistical investigations with uncovering natural laws about human behavior.

This deterministic (albeit not fatalistic) principle owes a debt to Adolphe Quetelet. In 1831, Quetelet published a map of property crimes in France, which was used to visually support his argument that, regardless of human agency, crime obeyed natural laws and increased in relation to increasing social inequality. Quetelets approach was empirical, experiential, and predicated on statistical enquiry. Later, his Sur lhomme et le dveloppement de ses facults, ou Essai de physique sociale (1835), the first work to apply statistical method to social problems, exerted a particularly strong influence over Nightingale. In this book she could perceive the intellectual culmination of a mind she thought keenly attuned, like hers, to the systematic collection of data.

Nightingale was acutely aware of the rhetorical power of infographics. She took much the same aesthetic delight in statistics as Priestley took in chronographs; they represented for her a moral imperative, a religious duty, writes Eyler, toward Gods divinely ordained plan. That said, Nightingales contribution to public health was thoroughly pragmatic. She was a shrewd publicist and political actor, but her legacy as a popularizer of infographics is not so clearly established. Those texts containing her diagrams were not commonly available in public library catalogs of the day.

Nightingales polar area diagrams (or exploded pie charts) owe a debt to William Playfairs innovations, but also, no doubt, to her long-term collaborator William Farr, who experimented with circular charts in his earlier publications. Lee Brasseur, an expert in the field of visualization, has set out a compelling critique of the visual rhetoric of three of Nightingales diagrams as they appear in her 16-page pamphlet, A Contribution to the Sanitary History of the British Army (1859) (a publication that attributes tables and diagrams to Farr). These three lithographic prints, published in a short, highly impactful pamphlet, comprise (according to Brasseur) a coherent (and persuasive) sequential progression in visual rhetoric.

The first, titled Diagrams of the Mortality in the Army in the East, sets out monthly mortality rates in the army during the first and second years of the war; the first (larger) diagram concerning mortality rates in the first year draws the viewers eye to the right, before a dotted line draws attention over to the smaller diagram on the left, concerning the second years mortality rates. The viewer is invited to juxtapose these mortality rates against a concentric circle in each diagram that expresses the average mortality rate of Manchester, one of the deadliest towns in England at the time.

Inviting the viewer to reflect upon what might be the cause of these discrepancies, the second chart, Diagram of the Causes of Mortality in the Army in the East demonstrates using color-coordinated polar area diagrams that the majority of fatalities are due to preventable disease. Having first set out the scale of the problem, and then second, having explored the reasons for the anomaly, Nightingale then sets out in a third diagram, comprising monthly mortality rates, the outcome of improvements that had been made after March 1855, in Scutari and Kulali army hospitals. Collectively, these three diagrams represent a devastating visual critique of the armys culpability in many needless deaths at the Crimean front.

Nightingales polar area diagrams play with the metaphorical implications in William Playfairs circle diagrams in a highly effective way. These charts challenge the seeming unity, continuity, and coherence of the phenomena they express. The variation in the scaling of each section implies a sense of discontinuity, but also the same spirit of cartographic empiricism that speaks through the wider statistical maps of the 19th century.

These forms embolden the viewer with a sense of power, authority, and purpose, to cast a scrutinizing lens over the problem of the social ills of the day. But they also represent discontinuity; things clearly cannot simply go on as they are change is implicit, change is necessary. This pamphlet is a multimodal medium, combining highly charged interpretive and explanatory discursive elements, into a compelling work of publicity. Nightingales approach speaks more to technique than to method. She sought to communicate Quetelets foundational statistics to a non-specialist, but nonetheless elite audience.

However, passionate statistician though she may have been, the Victorian press had, it seems, little to say about Nightingales innovations. Though read within (and presented to) an esteemed audience, the visualizations of Nightingale and Farr could hardly be said to have had a significant, direct public impact. It wouldnt be until the rise of popular almanacs toward the turn of the 20th century, and in turn the modern daily popular British press, that the wider public would begin to encounter infographics.

Murray Dick is a lecturer in multimedia journalism at Newcastle University and the author of The Infographic: A History of Data Graphics in News and Communications, from which this article is adapted.

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CDC Eases Post-Exposure Testing; Send in the Troops!; Anatomy of a Nursing Home Outbreak – MedPage Today

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People who don't show symptoms of COVID-19 need not be tested, even if they've been exposed to the virus, the CDC now says. (NBC News)

New York Gov. Andrew Cuomo (D) announced the state won't be canceling its quarantine requirement for visitors from certain COVID-19 hotspot states even though the CDC said such measures are no longer necessary. (New York Post)

As of 8:00 a.m. EDT Wednesday, the unofficial COVID-19 tally reached 5,779,395 cases and 178,533 deaths -- up 38,307 and 1,249 from this time a day ago.

A biotech lab in England is gearing up to manufacture AstraZeneca's COVID-19 vaccine if and when it's approved, but that deal is raising concerns about access and pricing. (CBS News, Kaiser Health News)

One hurdle for vaccine makers trying to secure deals in the EU -- a lack of full legal protection for side-effect-related claims. (Reuters)

Send in the troops: that's what Spain's prime minister is doing to help with a resurgence of COVID-19 in that country. (Reuters)

A nasal spray formulation of a vaccine candidate is showing promising results, University of Alabama researchers say. (AL.com)

Meanwhile, that same university has more than 500 coronavirus cases just 6 days after reopening, and Tuscaloosa's mayor has ordered local bars to close for 2 weeks. (Business Insider)

A nurses' union has sued two Florida hospitals, alleging that they are not adequately protecting workers from the coronavirus. (Bradenton Herald)

What was it like during the first COVID-19 nursing home outbreak in the U.S.? Katie Engelhart of the California Sunday Magazine digs in.

Do you think coronavirus test results take too long to come back? Watch what happens when flu season hits. (New York Times)

Remember that Biogen conference in Boston that was said to be a "superspreader" event? It's now thought to be responsible for 20,000 coronavirus infections, and nearly a third of the virus cases in Massachusetts are thought to come from the gene variant that originated there. (Becker's Hospital Review, Washington Post)

An early August wedding and reception in Maine is believed to be the source of 60 coronavirus cases in the state, including some cases among people -- residing in jails and nursing homes -- who did not attend the wedding. (CNN)

At the U.N., the U.S. rejected the notion of "an assumed right to abortion," after a working group on discrimination against women and girl's found that some U.S. states may have used the pandemic to curb access to the procedure. (Reuters)

In other news:

Joyce Frieden oversees MedPage Todays Washington coverage, including stories about Congress, the White House, the Supreme Court, healthcare trade associations, and federal agencies. She has 35 years of experience covering health policy. Follow

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Anatomy of a Goal: Ring sends the Crew to first defeat of 2020 MLS Season – Massive Report

Welcome back to the Anatomy of a Goal, where each week we dissect one goal (or near goal) from Columbus Crew SCs previous match.

For match seven of the 2020 MLS Season, we take a look at Alexander Rings 59th minute goal for New York City FC that gave City a 1-0 lead and send the Crew to their first loss of the 2020 campaign.

Here is a look at the goal from NYC FCs captain.

Columbus entered Mondays match against NYCFC on a six-match unbeaten streak to start the season. Due to COVID-19 protocols, the Black & Gold flew into New Jersey on match day and their sluggish legs through much of this match showed just how difficult getting a result on the road will be during this phase of the MLS season.

The Crew was once again without offensive fulcrum Lucas Zelarayan, and the offense continued to struggle without the Argentine playmaker. Offensive timing issues further plagued Columbus with three goals correctly called back as offside.

Rings game-winner directly follows a substitution and tactical change for the Black & Gold. Following a foul on Luis Diaz, Artur entered the match for the Costa Rican winger sending Darlington Nagbe up to the No. 10 spot and Pedro Santos out to the wing as the team finished the match against Chicago last week. Emmanuel Boateng entered for Derrick Etienne in a more like-for-like substitution.

Jonathan Mensah lines up the free kick after the substitutions are complete. He has the option to hit a pass to almost every Crew player on the field.

Mensah, keeping with the Caleb Porter system, plays a pass across Heber toward Aboubacar Keita. Heber then drops back toward the midfield. Hector Jimenez will provide a wide option to Keita and Sebastian Berhalter will also drift further toward the sideline bringing Rings defensive presence with him. Artur sticks further up the field.

Keita picks up the ball and has four immediate options. He can play a pass up the sideline to Jimenez, carry the ball forward, play a short pass to Berhalter or play a pass back to Mensah.

Keita takes a step sideways and spots Mensah heading back toward the 18-yard box. Ring has left Berhalter and is cutting toward Keita to apply a defensive press. Heber puts on the breaks and cuts back toward the passing lane between the two Columbus center backs.

Mensah notices Heber cutting back and points toward the box for a deeper pass from Keita.

Keita hits the pass toward the spot that Mensah has vacated as the captain points back to the penalty box. Heber sprints into the path of the ball.

Mensah realizes the ball was played behind him and without enough pace and plants hard to try to recover. Keita realizes that he has mishit the pass and sprints toward the middle of the field while Heber attempts to intercept the errant pass.

Heber gets near the ball the ball with Black & Gold defenders between him and goalkeeper Andrew Tarbell.

From behind the goal we can see just how close this pass was to missing Heber. The NYCFC striker has to stretch out his left foot to get on the end of the pass.

Unfortunately, Heber is able to intercept Keitas pass and carries the ball into the Columbus goal box. Ring sprints in behind Keita, forcing the Homegrown defender to decide whether to cut off Hebers angle to the back post or whether to track Rings run into the penalty box.

Keita cuts off Hebers angle to the back post leaving Ring to run free in behind. Heber now finds himself with the option to take a shot on goal or to slide a quick pass over to a wide open Ring.

Heber makes the safer choice and plays a simple square pass to Ring.

Ring tees up a first touch shot on goal as Keita and Tarbell scramble back toward the New York City captain.

Ring fires in a left-footed shot as Tarbell attempts to dive in front of the ball.

Tarbell has too much ground to make up as the ball sails past him . . .

. . . and into the back of the net.

Findings:

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