A Zoom Thanksgiving? Summer Could Give Way To A Bleaker Fall – Patch.com

Story by Carla K. Johnson, AP Medical Writer

As the Summer of COVID draws to a close, many experts fear an even bleaker fall and suggest that American families should start planning for Thanksgiving by Zoom.

Because of the many uncertainties, public health scientists say it's easier to forecast the weather on Thanksgiving Day than to predict how the U.S. coronavirus crisis will play out this autumn. But school reopenings, holiday travel and more indoor activity because of colder weather could all separately increase transmission of the virus and combine in ways that could multiply the threat, they say.

Here's one way it could go: As more schools open for in-person instruction and more college students return to campuses, small clusters of cases could widen into outbreaks in late September. Public fatigue over mask rules and other restrictions could stymie efforts to slow these infections.

A few weeks later, widening outbreaks could start to strain hospitals. If a bad flu season peaks in October, as happened in 2009, the pressure on the health care system could result in higher daily death tolls from the coronavirus. Dr. Robert Redfield, director of the Centers for Disease Control and Prevention, has said that scenario is his biggest fear.

One certainty is that the virus will still be around, said Jarad Niemi, a disease-modeling expert at Iowa State University.

"We will not have a vaccine yet and we will not have enough infected individuals for herd immunity to be helpful," Niemi said.

Fall may feel like a roller coaster of stop-and-start restrictions, as communities react to climbing hospital cases, said University of Texas disease modeler Lauren Ancel Meyers. Everyone should get a flu shot, she said, because if flu spreads widely, hospitals will begin to buckle and "that will compound the threat of COVID."

"The decisions we make today will fundamentally impact the safety and feasibility of what we can do next month and by Thanksgiving," Meyers said.

The virus is blamed for over 180,000 deaths and 6 million confirmed infections in the U.S. Worldwide, the death toll is put at almost 850,000, with over 25 million cases.

The U.S. is recording on average about 900 deaths a day from COVID-19, and newly confirmed infections per day are running at about 42,000, down from their peak in mid-July, when cases were topping out at over 70,000.

Around the country, a chicken processing plant in California will close this week for deep cleaning after nearly 400 workers got sick, including eight who died. And college campuses have been hit by outbreaks involving hundreds of students, blamed in some cases on too much partying. Schools including the University of North Carolina, Michigan State and Notre Dame have moved instruction online because of clusters on their campuses.

Several vaccines are in advanced testing, and researchers hope to have results later this year. But even if a vaccine is declared safe and effective by year's end, as some expect, there won't be enough for everyone who wants it right away.

Several companies are developing rapid, at-home tests, which conceivably could be used by families before a Thanksgiving gathering, but none has yet won approval.

More than 90 million adults are over 65 or have health problems, putting them in higher danger of severe consequences if they get sick with the coronavirus. Many of them and their families are starting to decide whether to book holiday flights.

Cassie Docking, 44, an urgent care nurse in Seattle, is telling her parents both cancer survivors that Thanksgiving will be by FaceTime only.

"We all want to get to 2021," she said, "and if that's what it takes, that's what we'll do."Caitlin Joyce's family is forging ahead with a holiday feast. They plan to set up plywood tables on sawhorses in a large garage so they can sit 6 feet apart.

"We'll be in our coats and our sweaters," said Joyce, 30, of Edmonds, Washington, who plans to travel to her grandparents' home in Virginia. "It will be almost like camping."

One widely cited disease model projects 2,086 U.S. deaths per day by Thanksgiving, more than double compared with today.

"In our family we will not have our extended family get-together. We will stick to the nuclear family," said Dr. Christopher Murray of the Institute for Health Metrics and Evaluation, one of the few models making a prediction for November.

Uncertainty is huge in Murray's model: Daily deaths could be as low as 1,500 by Thanksgiving or as high as 3,100. In a more optimistic scenario, daily deaths could range from 510 to 1,200 if nearly everyone wears masks. A more pessimistic scenario? From 2,700 to 6,500 daily deaths if social distancing rules continue to be lifted and are not reimposed.

With all the uncertainty, most disease modelers aren't looking that far ahead at least officially. Jeffrey Shaman, a public health expert at Columbia University, thinks the virus will spread more easily as the weather forces people indoors: "But what level of a bump? That's hard to say."

At Carnegie Mellon University in Pittsburgh, computer scientist Roni Rosenfeld's team uses machine learning to project COVID-19 deaths. The team's computer algorithm learns from patterns it finds in state and county data to improve its forecasts.

A five-time winner of a CDC competition for predicting flu season activity, Rosenfeld thinks his model's COVID-19 projections aren't very useful beyond four weeks because of the wild card of human behavior, including that of government officials.

"What happens very much depends on us," he said. "People, myself included, don't always behave rationally." Presented with the same facts, "the same person might behave differently depending on how sick and tired they are of the situation."

Like other disease modelers, Rosenfeld said the virus will still be with us at Thanksgiving, readily spreading at family gatherings. While his plans may yet change, he said he is going to travel with his wife to visit their adult children. They will wear masks and keep a safe distance during the visit.

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A Zoom Thanksgiving? Summer Could Give Way To A Bleaker Fall - Patch.com

We’re in the ‘pandemic era’ now, and the solution is for us to live ‘in greater harmony with nature’, Fauci says – TheBlaze

In a report co-authored by Dr. Anthony Fauci and David M. Morens of the National Institute of Allergy and Infectious Diseases, they write that the world is now in a "pandemic era" and suggest that the only solution is to live "in greater harmony with nature."

The remarks are part of a 16-page report in Cell that was published in August titled, "Emerging Pandemic Diseases: How We Got to COVID-19."

"COVID-19, recognized in late 2019, is but the latest example of an unexpected, novel, and devastating pandemic disease," they write. "One can conclude from this recent experience that we have entered a pandemic era. The causes of this new and dangerous situation are multifaceted, complex, and deserving of serious examination."

The report goes on to examine various pandemic diseases and the variety of factors that led to them, eventually getting to a conclusion that many of these "disease emergencies reflect our increasing inability to live in harmony with nature," pointing out that a number of pandemics have been exacerbated by "urbanization and crowding."

"Living in greater harmony with nature will require changes in human behavior as well as other radical changes that may take decades to achieve: rebuilding the infrastructures of human existence, from cities to homes to workplaces, to water and sewer systems, to recreational and gatherings venues," Fauci and Morens write. "In such a transformation we will need to prioritize changes in those human behaviors that constitute risks for the emergence of infectious diseases.

"Chief among them are reducing crowding at home, work, and in public places as well as minimizing environmental perturbations such as deforestation, intense urbanization, and intensive animal farming," they continue.

Acknowledging that diseases spread much more easily in a world that is more interconnected than ever, Fauci and Morens conclude that humans must think through how to avoid activities and developments that may lead to the emergence or spread of new diseases.

"COVID-19 is among the most vivid wake-up calls in over a century," they write. "It should force us to begin to think in earnest and collectively about living in more thoughtful and creative harmony with nature, even as we plan for nature's inevitable, and always unexpected, surprises."

The World Economic Forum recently published an article titled, "5 things COVID-19 has taught us about fighting climate change." The first takeaway was that "the planet will not wait."

"We need to set bold and ambitious targets to drive change the planet needs," writes the author, Salesforce Executive Vice President for Corporate Relations Suzanne DiBlanca. "Coming out of the COVID-19 crisis, we have an opportunity to combine a safe recovery with a sustainable recover. The EU has led the way by proposing a green recovery plan, which will use digitalization to boost jobs and growth, secure the resilience of societies, and put the health of our environment first."

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We're in the 'pandemic era' now, and the solution is for us to live 'in greater harmony with nature', Fauci says - TheBlaze

In Peacock’s ‘Brave New World,’ Everyone Is Very Happy or So It Seems | Jen Maffessanti – Foundation for Economic

What do people need to be happy?

In the new Peacock original series Brave New World, as well as the 1932 Aldous Huxley novel its based on, happiness in the fictional society of New London is mandated by the powers that be. Everyone in New London is genetically engineered and psychologically conditioned to be suited to, and satisfied with, a specific role in their society. Theyre encouraged to the point of compulsion to engage in every kind of hedonistic indulgence imaginable. There are no difficult decisions to be made. And for those pesky times when discomfort or anxiety rear their ugly heads, the perfectly effective, perfectly side-effect-free drug Soma is there to smooth it away.

Everyone is happy.

Except that theyre not.

But why? Why, when every physical need is amply satisfied and every pleasure available and every discomfort eased, would people not be happy? Why would a worker kill himself in the opening act? Why would some citizens need the occasional reconditioning in order to bring them back in line? Why do the residents of New London feel the need for so much Soma?

Especially given that the fictional world of New London that Huxley imagined back in the early 1930s rather closely resembles the fantasies of luxury communism that have been recently proposed, its an important question.

Happiness is weird, which may seem weird to say. After all, we all know what happiness is. Dont we?

Broadly speaking, yes, we can define happiness as a general state of contentment with ones circumstances. Generally, people who are happy know and pursue their lifes purpose, they smile a lot, theyre meeting their basic needs for survival, theyre able to give and receive gifts and attention without resentment, and are free of strife.

But thats not all that we need to be happy. For a lot of people, not having to fuss with making decisions about difficult thingsor even easy things!sounds pretty relaxing. Never having to hear, see, or otherwise experience activities or ideas they find objectionable feels comforting. A place for everyone and everyone in their place with no worry about whether or not its what they want to be doing with their life appears neat, clean, and ideal. Surely, this is what happiness for everyone looks like.

And maybe, just maybe, it would be nice, for a little while. Just like a vacation is nice, for a little while. When bills are due and stress levels are high and the kids are asking whats for dinner, yes, I certainly understand the appeal.

But I wouldnt want to live my entire life that way. And in practice, highly-controlled societies like the Soviet Union or modern-day North Korea, where what you do, what you consume, where you go, and who you do it all with is decided by someone else, happiness tends to be in pretty short supply.

This is because happiness is intrinsically tied to personal choice and autonomy. Its about feeling like you have control over your own life. Material comforts are nice and all, but they dont seem to have that big of an impact on peoples happiness levels. But studies have shown that autonomy is the number one predictor of happiness.

And it is autonomy thats conspicuously missing from the fictional society of New London and from real-life command-and-control societies around the world.

But maybe having an easy, cushy life would still be better, if we were able to arrange it so a certain measure of autonomy could be accommodated. After all, its so distressing to worry about bills and dealing with people who dont agree with you, to deal with anxiety and pain. Wouldnt we be better if we could eliminate those things?

No, not really.

And it isnt as though we havent tried. We have. Certain portions of American society have worked very hard to eliminate psychological discomfort with intellectual coddling, safe spaces, and a hyper-focus on self-esteem.

The result is millions of people who dont know how to handle adversity or discomfort. The result is fragility. Our society, broadly speaking, is wealthier, healthier, and more comfortable than its ever been, and yet, more people are struggling with anxiety than ever before.

The human psyche doesnt actually do well with perfect comfort and zero difficulty. It isnt particularly pleasant, but distress, discomfort, and disorder can be good for us. Adversity actually makes us stronger. Author Nassim Nicolas Taleb coined the term antifragile to describe this phenomenon. He explains:

Some things benefit from shocks; they thrive and grow when exposed to volatility, randomness, disorder, and stressors and love adventure, risk, and uncertainty. Yet, in spite of the ubiquity of the phenomenon, there is no word for the exact opposite of fragile. Let us call it antifragile. Antifragility is beyond resilience or robustness. The resilient resists shocks and stays the same; the antifragile gets better.

And the human psyche is antifragile.

Even if it were possible to perfectly control our social environment to shield ourselves from conflict and experience only pleasurable interactions like in New Londonand, to be clear, it emphatically isnt possibleour world itself is a chaotic, largely unpredictable place. As we are all too keenly aware right now, disease and natural disasters are always a possibility, even if nothing else were on the table.

Disruptions to supply lines, changes in our understanding of the natural world, or simply growing up are all shocks to our systems. If we dont allow ourselves to experience and become accustomed to the discomfort of change, not only will we as individuals and as a society stagnate, we will become so fragile that a single hammer-blow of unanticipated hardship could shatter us.

Happiness cannot be engineered. Humans cannot have allor even a slim majorityof their choices made for them and still be happy. Autonomythat is, freedomis necessary for human happiness.

While the psychological research on this might be relatively recent, this wisdom did not escape early 20th-century economists. Economics is, after all, at its core, the study of human behavior and interaction. Austrian economist Ludwig von Mises wrote in his book Liberalism in 1927,

It is impossible, in the long run, to subject men against their will to a regime that they reject. Whoever tries to do so by force will ultimately come to grief, and the struggles provoked by his attempt will do more harm than the worst government based on the consent of the governed could ever do. Men cannot be made happy against their will.

The tendency of so many generally-well-meaning people, from academics to helicopter parents, to socially engineer a perfectly happy society with no strife, no discord, no struggle will always have the opposite effect. The attempts to fix the problems with human nature will always backfire.

People cant be forced into being better. People cannot be forced into being happy.

And while freedom is no guarantee of happiness, it is essential if we are ever to be able to find it on our own.

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In Peacock's 'Brave New World,' Everyone Is Very Happy or So It Seems | Jen Maffessanti - Foundation for Economic

Teen who was told he would never sit an exam prepares to start genetics course at UCD – Irish Examiner

A teenager with autism who was told he was unlikely to ever sit a state exam has been offered a college place to study genetics.

He is determined to find out why his parents - who don't have autism - had four children on the spectrum.

Tristan Lennon from Mornington, Co Meath is getting ready to take his place at University College Dublin (UCD) after securing the extra points he needed through a post leaving certificate course (PLC). The 18-year-old student is encouraging people to take a PLC course, even if they receive the points they need for their preferred course, as he said it gives you the grounding you need for college life.

Tristan's mum Carol was told before his Junior Certificate that it was unlikely that he would ever sit a state exam. She fought to get the additional resources he needed to have the same chance as any other pupil.

"He needed one-on-one help in a lot of subjects so we were told he wasn't expected to sit any state exams due to his needs but I insisted and persisted and, just two days before the Junior Certificate, he was given all he needed as emergency measures," she said.

"And he did really well.

"Again, before the Leaving Certificate, we were told there was no resource accommodation available and again I pulled out all the stops to get it for him."

Tristan, now 18, missed out on the points he needed to get straight into his course but did a PLC, receiving ten distinctions and enough extra merits to get his place in the genetics course in UCD through the CAO round zero.

Tristan was one of 4,411 applicants to receive 5,432 offers for third-level places through the CAO round zero in early August.

Those who fall into the round zero category include graduate entry medicine applicants, additional mature applicants, deferred and access applicants, as well as those presenting QQI FET/FETAC qualifications for courses with a quota for such applicants.

"He has come a long way. We didn't think he would get on the train independently to go to his work experience in Dublin as part of the course but he did and he even stood up to a gang who assaulted him on his first journey," his proud mum said.

Four of Carol's five children have been diagnosed with autism. She has fought hard for extra services for her children over the years.

I've learned that you have to fight and fight hard to be heard when you have a child with autism in Ireland.

"And I'm very proud of where my children are today because of any supports and resources that I've fought for to help them to get the chance they deserve in life."

Tristan has encouraged everyone to consider a PLC course, even if they get the points they need for their preferred couse.

"The PLC gave me a grounding of how college worked and taught me how to commute independently and how to start independently learning," he said.

"Now I'm ready to concentrate solely on my course. My current interest is in genetics and I would like to research if there is a concrete link between the make-up of genes and disabilities.

"I'd love to find out why my parents, who don't have autism, had four out of five children with autism."

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Teen who was told he would never sit an exam prepares to start genetics course at UCD - Irish Examiner

New Guinea singing dogs, renowned for their ethereal howls, are no longer believed to be extinct – Salon

Human activity on Earth has led to a surge in extinctions,which is what makes it so excitingthat the New Guinea Singing Dog, which scientists have thought for decades only survived in captivity, may still survive in the wild after all. The singing dogs, which can breed with domesticated dogs and are closely related to Dingos,are beloved for their ethereal, choral howls.

The study, which was published Monday in Proceedings of the National Academy of Sciences, analyzed the genetic material of a population of canids known as highland wild dogs that were discovered in the New Guinea highlands. These dogs howled in ways that sounded an awful lot like the New Guinea Singing Dogs of the past, even though the species has not been seen outside of inbred zoo populations and the occasional exotic pet collection since the 1950s. Scientists became intrigued in 2012 after an ecotourism guide photographed an animal that looked like a New Guinea Singing Dog and, by 2018, a researcher was able to collect DNA samples from three specimens (two temporarily trapped dogs and a third one that had died).

The DNA results came back,and provided scientists with good news: These were not ordinary village dogs that had wandered away from their homes, but were direct relatives ofNew Guinea Singing Dogs. To be exact, the wild dogsshared a 72 percent genetic similarity with New Guinea Singing Dogs that are held in captivity and that genetic diversity among the wild dogs is probably a good thing, since all of the captive dogs are descended from seven or eight wild ancestors.

This news has major implications for how scientists and the general public can understand dogs.

"These dogs form a group with Dingos that appear to have separated from the ancestors of the average breed dog long before breeds were created," Dr. Heidi G. Parker, a co-author of the study who works at the Dog Genome Project for the National Human Genome Research Institute at the National Institutes of Health, told Salon by email. "They may represent one of the earliest forms of dogs."

She added that our new information about New Guinea Singing Dogs may shed new light on the domesticated dog breeds that so many people know and love.

"Studying this group of dogs may help us establish a timeline for the development of the modern breed types that are so popular now," Parker explained. "Not when the breeds were created by when the modern types of dogs became abundant."

Parker expressed cautious hope that the New Guinea Singing Dogs could be revived.

"We don't know enough right now about the size of the remaining population and how diverse it is. We hope that this will increase interest in these dogs and in preserving them," Parker told Salon.

Salon also spoke with James McIntyre,director and director of field research at New Guinea Highland Wild Dog Foundation, who conducted all of the field research involved in the study. He explained that New Guinea Singing Dogs are very different from the domesticated variety to which so many of us have grown accustomed.

"if you looked at it from a relative distance, you would say, 'Oh, that's a dog,' but if you were to get a little bit closer, there's something very unique about it," McIntyre told Salon. "And you would probably ask somebody, 'Hey, what kind of dog is that?' Because there is something that is unique to them that you don't see and haven't seen. And a lot of it is the way their eyes are set and all that these dogs are extremely intelligent, athletic, flexible. They have a very strong predatory urge."

After noting that it takes a "special kind of person" to keep one of these dogs in their home, McIntyre elaborated that "they don't come when they're called. And like I said, they're very predatory, so you don't want to have a little Shih Tzu or your cat out when this dog gets out. It's just their nature. They're highly predatory. They're more cat-like in their intelligence and disposition than they are like a dog, and in their athletic ability they're almost somewhere between a monkey and a cat then they would be a dog. They're extremely agile."

Study co-author Dr.Elaine Ostrander told Salon that scientists had believed that the dogs were extinct in the wild for half a century.

"So the punchline is that people thought New Guinea Singing Dogs were extinct in the wild and this study shows that they, in fact, are not," Ostrander, an American geneticist at the National Human Genome Research Institute of the National Institutes of Health, told Salon by email. "This changes what we thought about dogs. We know that New Guinea Singing Dogs have not been seen in the wild for over 50 years. The only ones that we knew existed are in conservation centers and are derived from very small numbers of founders many decades ago. Those dogs are losing genetic diversity."

Ostrander said the discovery of a wild population gives hope that the species can be prevented from suffering a genetic bottleneck, both in the wild and in captivity. "The discovery that the Highland Wild Dogs are the original New Guinea Singing Dog give us hope that we can restore the breed/species to its previous genetic status and diversity," Ostrander said.

There have been other intriguing studies of canid genetics to come out in 2020.A study in Junepublished in the journal Proceedings of the Royal Society B revealed that London foxes could be unintentionally self-domesticating because of their close proximity to human beings. The physical signs included urban foxes having wider snout tips and smaller brain cases. Later that same month, a studypublished in the journal Science found that sled dogs like Alaskan Malamutes, Siberian Huskies and Greenland sledgedogs are genetically connected to an Arctic dog from roughly9,500 years ago. This more than tripled the length of time that scientists believed sled dogs had been around.

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New Guinea singing dogs, renowned for their ethereal howls, are no longer believed to be extinct - Salon

Coming Home to the Klamath – Hakai Magazine

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Four aging dams on the Klamath River are coming down. Their completion between 1921 and 1964 brought hydroelectric power to Northern California. It also blocked hundreds of kilometers of fish habitat, causing chinook salmon to effectively disappear from the upper river basin. But the removal of dams is no guarantee the fish will return, so a team of wildlife researchers hopes it can coax the fish to repopulate the river by exploiting a new discovery about salmon genetics.

The Klamath was once the third-largest salmon-producing river in the United States, and its fish are still prized by Indigenous tribes that live along its winding path. In the Klamath, as in many other rivers, chinook salmon come in two main types: spring-run and fall-run. Spring-run fish start their migration from the rivers estuary four to six months before their fall-run cousins, and their return spawning run takes them farther up the river. Over time, however, human activities including mining, agriculture, and dam construction all but swept spring-run fish from the upper Klamath. Today, only the fall run of chinook salmon is large enough to support fishing.

Though dam removal has yet to beginthat wont come for at least another yearJohn Carlos Garza and Anne Beulke are already investigating how to replenish spring-run chinook in the upper reaches of the Klamath River Basin. Garza is a geneticist with the US National Oceanic and Atmospheric Administrations Southwest Fisheries Science Center and a researcher at the University of California, Santa Cruz, where Beulke is pursuing doctoral studies. Their research was motivated by a mystery of salmon behavior.

People have long recognized spring- and fall-run patterns, but scientists couldnt actually explain what caused this distinction. We found these curious patterns again and again, Garza says, even though they were the same type of salmon. Once they acquired the technology to quickly sequence fish DNA, however, the scientists started analyzing the genes of salmon that spawned at different times. We found a single region in the genome thats responsible for the difference between early- and late-migrating fish, Garza says. This led them to wonder whether they could re-create the missing spring-run salmon by crossing fall-run salmon with those that have the early-migration gene.

Garza and Beulke are now preparing to apply their discovery. They plan to crossbreed and release hatchery-raised spring-run chinook from the nearby Trinity River with fall-run chinook from the Klamath. When the fish return to the hatchery once more to spawn, theyll crossbreed them again with more fish from the Klamath. With every generation, youll get fish with a higher percentage of their ancestry from the Klamath River, he says.

Ideally, Garza and Beulke should begin their project this September to take advantage of the 2020 spawning season. Their work was scheduled to start in March, but stakeholder agencies have been slow to agree. The current pandemic may influence their schedule, too. I cant even get into the lab right now, Beulke says.

Although other plans have proposed reintroducing spring-run fish from nearby rivers, Garzas method has the advantage of preserving the evolutionary history of the Klamath River fish. During his analyses, Garza noticed that some fall-run salmon included genetic descendants of the Klamaths earlier spring-run fish. Crossing spring- and fall-run fish from within the river, then, would enable new spring-run generations to also preserve the adaptive genetic patterns of their Klamath ancestors.

At this point, I like Carloss approach, says Kathleen OMalley, a geneticist at Oregon State University. Its a great opportunity to test the connections between a genomic region and run timing. There are a lot of variables, she adds, but its certainly a worthwhile project. It may take more years than anticipated, though, to actually get enough data points.

Garza is comfortable taking the long view. This is a process that occurs naturally, he says. Were just accelerating things. Within 10 years, we could have thriving spring-run chinook salmon populations.

After all, the dams have been up for 100 years.

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Coming Home to the Klamath - Hakai Magazine

Global Preimplantation Genetics Diagnosis Market to Flourish With An Impressive CAGR by 2020-2027 Know The Latest Covid19 Impact Analysis – Bulletin…

Reportspedia announces a new report titled GlobalPreimplantation Genetics Diagnosis Market, which outlines the rationale standpoint of the unpretentious forces of the market. It announces the addition of another new dimension to this industry explaining the performance of the major players. The Preimplantation Genetics Diagnosis Market has also been segmented on the basis of the provincial players, out of which some are well established while some have newly entered the global market. These players have established actions such as research and development, determined to bring in new services that can efficiently compete with the other established players.

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Global Preimplantation Genetics Diagnosis Market Insight and Forecast to 2027

Chapter 1Preimplantation Genetics Diagnosis Market Report Overview

Chapter 2Global Growth Trends

Chapter 3Market Competition by Manufacturers

Chapter 4Preimplantation Genetics Diagnosis by Regions

Chapter 5Preimplantation Genetics Diagnosis by Region

Chapter 6Preimplantation Genetics Diagnosis Market by Type (2020-2027)

Chapter 7Preimplantation Genetics Diagnosis Market by Application (2020-2027)

strong>Chapter 8Company Profiles and Key Figures in Preimplantation Genetics Diagnosis Business

Chapter 9Production and Supply Forecast

Chapter 10 Marketing Channel, Distributors, and Customers

Chapter 11 Industry Trends and Advanced Strategy

Chapter 12Conclusions

Chapter 13Appendix

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Global Preimplantation Genetics Diagnosis Market to Flourish With An Impressive CAGR by 2020-2027 Know The Latest Covid19 Impact Analysis - Bulletin...

Allergies vs. COVID: KU doctors give tips on knowing the difference – hays Post

LEFT to RIGHT: Dr. Dana Hawkinson, University of Kansas Health Center medical director of infection prevention and control; Dr. Steve Stites, chief medical officer; andDr. Selina Gierer, specialist in allergy, immunology and rheumatology medicine.

By CRISTINA JANNEYHays Post

Is that runny nose and cough COVID or just your run-of-the-mill seasonal allergies?

Doctors at the University of Kansas Health System tried to give viewers tips on how to distinguish between the two during their daily news briefing Wednesday.

Dr. Steve Stites, chief medical officer, and Dr.Dana Hawkinson, medical director of infection prevention and control, were joined byDr. Selina Gierer, specialist inallergy, immunology and rheumatology medicine, andear, nose and throat surgeon Dr. Keith Sale.

Gierer said Kansas has reached its peak allergy season. Children are also returning to school and can be exposed to viral infections.

"It is always a challenge when we go back to school when kids get any viral infection on top of season allergies trying to pick a part what's an illness and what is an allergy symptom," she said.

Itchy and water eyes as well as sneezing are common symptoms of allergies, but not of COVID-19.

Then there is an overlap zone for both allergies and COVID,Gierer said.

These include cough, fatigue, headache, sore throat, shortness of breath and runny nose.

"Ultimately, if you are having fever, if your symptoms are not typical for your allergy symptoms,"Gierer said, "perhaps this is not a typical allergy season for you.

"If you are having cough, if you are having congestion and you are having change in your sense of smell, it's time for you to be thinking about contacting your doctor to get tested for coronavirus."

She suggested keeping control of your allergy symptoms and avoiding people who are sick.

Monitor your triggers, such as dust, mold, pollen or animals. Monitor the local pollen count. Stay on your allergy medications.

"If you know you are going to be doing yard work, and the next day you feel itchy and drippy and sneezy, you can probably attribute that to your allergies and not an acute onset of coronavirus,"Gierer said.

Asthma is an underlying medical condition that increases the likelihood of complications from coronavirus. However, it is on the lower end of the range of complicating factors.

Asthma is much less common to cause complications than obesity and hypertension,Gierer said.

However, one of the biggest triggers of asthma is a viral infection. She said it is also important to keep your asthma under control by staying on medications, avoiding triggers and keeping a 30-day supply of medication on hand.

Dr. Sale saw a patient in his clinic who was having typical symptoms for allergies, such as a runny nose, but was not getting better on her normal medications.

She thought she had a sinus infection or something else. A friend from out of town had visited the week before. She was tested for COVID and was surprised with a positive COVID test, Sale said.

Sale said his office is taking COVID precautions, including using PPE, hand sanitizing between patients and patients wearing masks unless their nose or mouth is being examined.

Gierer said allergy medication or a rescue inhaler will probably not help with COVID-19 symptoms.

Sale said fatigue may be common to both allergies and COVID, but the persistence of the symptom may be a sign of the later.

Gierer said, "If the allergy medications are not working, that might trigger you to think there is something else going on."

Hawkinson said scientists are working to combine testing for flu and COVID-19. He said if a patient has a nasal swab for COVID-19, a lab could use that same sample to test for flu and RSV.

RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults, according the Centers for Disease Control.

The flu season is in full swing in South Africa and Australia and has been lighter this year there than in years past,Hawkinson said. He said that could be in part to mask use and increased hand washing.

KU Med is working on mass flu vaccination at this time.

Gierer urged members of the public to get flu vaccines. That is usually recommended starting in October.

The doctors also gave tips on staying in good general health.

You can naturally boost your immune system by getting adequate sleep, eating a healthy diet, as well as hand washing and staying away from people who are sick.

Those tips can help with COVID-19, flu or RSV.

Sale also said caring for your mental health can have an effect on maintaining physical health, which includes socializing in a safe way.

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Allergies vs. COVID: KU doctors give tips on knowing the difference - hays Post

‘I Am a Scientist Working With Severe Cases of COVID-19’ – Newsweek

Before the pandemic, I was studying immunology in the field of virus infections. I am a professor of immunobiology and molecular, cellular and developmental biology at Yale School of Medicine, and an investigator of the Howard Hughes Medical Institute. With my team at Yale's Iwasaki lab, we had been studying how the immune system detects viruses and how innate and adaptive immune systems are connected. Based on these insights, we are designing better vaccines.

We had been studying viruses including herpes, influenza and Zika for years, so when SARS-CoV-2 (COVID-19) hit we were prepared to tackle the questions it provoked. At the end of February, we started pivoting our work to focus on COVID-19. Our first effort was mostly focused on testing, because in the early stages of the virus there was no real testing capacity in the U.S.

With a number of collaborators, we helped set up a polymerase chain reaction (PCR) based testing strategy, and carried out numerous PCR testing in the lab to help identify COVID-19 infected patients and healthcare workers.

In parallel, my lab quickly moved into studying immunology, which is our specialty.

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Now, in September in Connecticut, there are very few COVID-19 cases. But back in March and April we were seeing cases spiking in the state. So, we had this unique opportunity to start enrolling patients at Yale New Haven Hospital, which was seeing many cases of COVID-19, as part of our Yale IMPACT (Implementing Medical and Public Health Action Against Coronavirus CT) study. We were able to do white blood cell analysis on 113 patients to study and follow them over time to understand the changes in their immune responses in real time, and that work has resulted in a study that was published in Nature.

Our aim was to study the immune response in different people; those who were having a moderate case of COVID-19 and are recovering from the infection, and those who were having a severe response to the COVID-19 virus, some of whom unfortunately did pass away from this disease.

Every four days or so, we would take their nasopharyngeal swabs (samples of secretions from the nose and throat) and blood and analyse what was happening, and that led to very interesting insights. Firstly, with the virus load that we measure from the patients' nose, we observed the severe and moderate patients started off with similar levels. But then, though the moderate patients were able to clear the virus eventually, the severe patients never really could.

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So the first thing we noticed was that one of the elements that distinguished between moderate and severe cases of the disease was the inability to control the virus in the severe case. The second thing we learned when we collected patients' plasma and observed their cytokines.

Cytokines are small proteins important in cell signalling because they transmit information from one cell to another.

The COVID-19 viral load in severe patients was associated with increased levels of these proteins. They can have a positive or a negative effect on the body's immune response to a disease, depending on the information they are transmitting between cells.

It turns out that there are a number of distinct features that are associated with the COVID-19 patients we observed and that interestingly correlate with their recovery from this disease. I was really floored when I saw these features, because there were some unusual things that we had not anticipated seeing.

Essentially, we saw that patients who eventually recovered had proteins (growth factors) in their blood that were encouraging their cells to repair. Growth factors can repair the damaged tissue in blood vessels and lung cells that happens during viral infection. In contrast, the patients who went on to have really severe cases of COVID-19 had proteins in their blood that were misfiring in all sorts of strange ways, and in some cases, reacting as if there was a parasite in the body!

It's pretty unusual during a viral infection to have anti-parasite responses going offbut many of the very severe patients we monitored exhibited these.

Compared to other viruses we have been studying over the years, we had never seen this kind of anti-parasite response coming up. So, it's likely that this virus is doing something to the host that is disorienting them in some way that allows this type of misfiring to occur. We don't know what that is yet, it may be intrinsic to the virus or it may be somehow the host is being triggered by some features of this virus that is elevating all kinds of these cytokine proteins. It may even be a body's way of trying to recover from infection.

When the patients were clustered based on their cytokine levels, they separated out into three clusters. We observed that patients who recovered didn't have much in the way of these misfiring proteins, but the second cluster of severe cases and the third cluster of very severe cases both did, and the third cluster had very rapid decline with the disease. That third cluster included patients who had the greatest numbers of misfiring proteins.

When I first saw these unusual signatures, I thought there was some technical glitch. So I asked the scientists to make sure they repeated this analysis multiple times, and these signatures kept coming up. But then during the course of study we started seeing other pre-prints, scientific papers that have not yet been peer-reviewed, that were reporting these anti-parasite responses also. So we knew we weren't alone in seeing this, and now we have seen several studies that confirm this.

One of the things that we reported is that even during the first 12 days of COVID-19 symptom onset there are certain proteins mentioned above that correlate with worse COVID-19 disease outcome. So, by measuring these early, we can inform clinicians that a patient, if they exhibit such cytokine proteins, is someone to pay attention to versus others who may look just as sick but aren't exhibiting in the same way.

In addition, we found bio-markers that we can use to look at patients to help predict what might happen. It's very useful to have this information because you can prepare Intensive Care Unit (ICU) beds in anticipation, as well as to potentially give these patients more suitable treatment.

Way before our COVID-19 study came out I had been tweeting about targeting inflammasomes because we have seen evidence of that activation in multiple papers. Inflammasomes are one type of inflammation that happens during a severe infection.

As the name suggests, inflammasomes are a very toxic form of inflammation. It is a large protein complex that forms inside the cell in response to bacterial and viral infection. Inflammasomes can transform cytokine proteins such as IL-1b and IL-18 into active forms. It can also cause "fiery death" of cells, which is known as pyroptosis. We found clear signatures of inflammasome activation that correlated with worse disease and death from COVID-19.

My lab had the knowledge and tools to react before COVID-19 hit, and it is an amazing privilege to be able to work on a pandemic to try and help people. We feel very energized because we are helping people and there are tangibles that come out of this type of research. Things are happening in real time; people are reaching out to me with different ideas for clinical trials based on what we have found. It's really exciting that a study result can trigger clinical trials in a very rapid manner, and be able to predict what might happen using a mouse model we developed to mimic COVID-19.

I feel honored to be working in this area. The pandemic has given me an opportunity to communicate science because more people are now interested. This real interest in immunology and vaccines is also an opportunity for me to educate the public about the immune system. Immunology is becoming extremely important now that public health measures have failed in many countries. Now, we really need the immune system to be able to kick in with the right vaccines to protect us.

I hope that our insights will help people cope with this infection better and eventually, recover. We continue to investigate this virus and have recently released research into whether immune responses to COVID-19 differ between the sexes.

To help just even one person survive this virus would be the most gratifying thing a scientist could hope for.

Professor Akiko Iwasaki focuses on the mechanisms of immune defense against viruses at mucosal surfaces, which are a major site of entry for infectious agents. She is a professor of immunobiology and molecular, cellular and developmental biology at Yale School of Medicine, and an investigator of the Howard Hughes Medical Institute. Professor Iwasaki has received numerous awards and honors for her work and is also well known for her Twitter advocacy on women and underrepresented minorities in the science and medicine fields. You can follow her on Twitter @VirusesImmunity

All views expressed in this piece are the writer's own.

As told to Jenny Haward.

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'I Am a Scientist Working With Severe Cases of COVID-19' - Newsweek

Assenting: The well-formed mind knows all cultures – The Troubadour Online

Leo Brian Schafer

Catholic Values Columnist

The premise we are discussing today seems to have an obvious solution.

Education, after all, is intended to be the communication of truth, and other religions Islam, Judaism and Protestant denominations are untrue. Why, then, should impressionable children be taught about other religions? All that would seem to do is cause them to question the truth of Christ and stray from the Gospel.

And does the Gospel not tell us that whoever causes one of these little ones who believe in Me to stumble, it would be better for him to have a heavy millstone hung around his neck, and to be drowned in the depth of the sea?

What possible benefit could be borne from the support of this proposal?

Consider the statement at hand. Children should be taught about other religion in schools is not a statement of proselytization or evangelization, but one of education. Being taught about strictly means that children will be told that other religions exist.

This brings us to the foundation of the matter. The core of what we are considering, perhaps, is not a question of religion, but one of culture and how culture is taught.

As Christians, we are called to evangelize, to go out to all nations and baptize. How can we be prepared to do this when the only religion, the only culture we are exposed to during our most formative years is our own?

Yes, learning Plato, Aristotle, Augustine, and the other great thinkers of our tradition is wholly beneficial to our greater formation. But how much greater would it be to aid in our call to evangelization to read Al-Ghazzali, Dawkins, Gdel and Kierkegaard?

To read our opposition through a Catholic lens, to learn about foreign traditions and cultures in order to more adequately carry out our calling to evangelization is not a bad thing, and is, in fact something that should be required of us.

That is not to say, however, that there are drawbacks and downsides.

Yes, teachers who believe in a more universalist philosophy may take all the good that we intend and flip it on its head, instilling their poisonous beliefs into Catholic children. That is to be avoided at any cost, so the conditions for this should be struck, and the dangerous notion of teaching about other religions in schools should be abandoned.

Or should it? Teachers who believe that abortion is a human right may instill their poisonous beliefs on children, so biology and embryology should not be taught. More aptly, teachers who believe (insert heresy here) may instill their poison into children so theology should not be taught.

So it goes for any subject. Some teachers believe false teaching x, so subject y should not be taught.

The very suggestion is preposterous. This debilitating fear of lies is valid one who loves the truth by definition hates lies but we cannot let this fear prevent us from greater things.

Yes, a bad world cultures teacher can corrupt. But so can a bad theology teacher, chemistry teacher or even a business teacher.

It is wholly beneficial to the Christian life to be exposed to other religions and schools of thought in order to be better prepared to serve the universal calling bestowed on us all, to evangelize all nations.

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Assenting: The well-formed mind knows all cultures - The Troubadour Online