Category Archives: Physiology

Master of Science in Medical Physiology program admissions open office hour – The Daily | Case Western Reserve University

Case Western Reserve University students are invited to join the Master of Science in Medical Physiology program for a virtual admissions open office hour Thursday, Jan. 18, at 1 p.m.

Samantha Baker, director of admissions, will be available to answer questions about admissions, curriculum, enrichment experiences, life in Cleveland, student successes and more. This is a drop-in style session; there will not be a formal presentation.

Get more information.

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Master of Science in Medical Physiology program admissions open office hour - The Daily | Case Western Reserve University

The Impact of GATAD2B Mutations on Brain Function and Development – Medriva

The Impact of GATAD2B Mutations on Brain Function and Development

One of the fundamental aspects of understanding neurodevelopmental disorders and intellectual disabilities is to explore the underlying genetic factors. A gene that has been drawing attention in recent years is GATAD2B. This gene is implicated in brain development and physiology, and mutations in it can lead to profound effects, particularly on cognitive function.

A recent study, focusing on the role of GATAD2B, utilized a mouse model with an inactivating mutation in Gatad2b. The research findings indicated that mutant Gatad2b mice exhibited behavioral and learning abnormalities similar to the human phenotype. These abnormalities were accompanied by abnormal cortical development and gene expression patterns, suggesting that GATAD2B mutations result in abnormal epigenetic transcriptional regulation of corticogenesis, thereby leading to intellectual disability.

Several scientific techniques were employed to understand the role and impact of GATAD2B mutations on brain development. Quantitative PCR was used to assess Gatad2b expression levels in the brain of mice, and Western blot analysis was performed to detect the Gatad2b protein. These techniques were coupled with histological analysis and behavioral tests to evaluate cognitive function in the mutant mice.

Furthermore, the research employed single-cell RNA sequencing to identify shared cell states across different samples. It also conducted gene ontology enrichment analysis to gain insights into the pathogenesis mechanisms associated with GATAD2B haploinsufficiency. The study included a detailed description of the experimental procedures and ethical considerations, ensuring the integrity of the scientific process.

The findings of this study contribute significantly to the understanding of GATAD2B and its implications for brain function and development. The observation of abnormal cortical development and gene expression in mutant mice provides valuable insights into the potential pathophysiological mechanisms underpinning neurodevelopmental disorders associated with GATAD2B mutations.

This research also highlights the potential of GATAD2B as a therapeutic target for neurological disorders. Given its role in regulating gene expression and its impact on cognitive function, targeting GATAD2B could pave the way for innovative therapies in neurodevelopmental disorders and intellectual disabilities.

For more information on the role of GATAD2B in brain development and physiology, you may refer to these resources:

They provide detailed information on the role of GATAD2B in brain development, its function in regulating gene expression, and its impact on neurodevelopmental disorders.

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Influence of Sleep-Disordered Breathing and Hypoxia on AF: A Pulmonary Physiological Perspective – Physician’s Weekly

The following is a summary of SleepDisordered Breathing, Hypoxia, and Pulmonary Physiologic Influences in Atrial Fibrillation, published in the November 2023 issue of Cardiology by Heinzinger et al.

In this study, using a substantial clinical cohort, researchers investigated the link between sleep-disordered breathing, sleep-related hypoxia, and atrial fibrillation (AF) development. The relationship between sleep-related hypoxia, pulmonary physiology, and their contributions to the onset of AF remains ambiguous, prompting the comprehensive analysis. Their retrospective cohort comprised patients undergoing sleep studies at Cleveland Clinic between January 2, 2000, and December 30, 2015. Using Cox proportional hazards models, they assessed various parameters, including apnea-hypopnea index, oxygen saturation levels, and end-tidal carbon dioxide about incident AF, adjusting for multiple factors. The cohort of 42,057 individuals, with a median age of 50.7 years and diverse demographic characteristics, saw 4.6% developing AF within 5 years. Elevated apnea-hypopnea index, reduced oxygen saturation levels, and increased carbon dioxide were associated with heightened AF risk. Specifically, a 10-unit increase in the apnea-hypopnea index led to a 2% higher risk, while similar changes in oxygen saturation levels were linked to a 6% to 30% increased AF risk.

After considering spirometry factors, sleep-related hypoxia remained significantly associated with incident AF, indicating a substantial role in AF development independent of pulmonary physiological impairment. These findings underscore the substantial impact of sleep-related hypoxia on AF incidence, highlighting its significance even when accounting for pulmonary physiological factors.

Source: ahajournals.org/doi/10.1161/JAHA.123.031462

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Influence of Sleep-Disordered Breathing and Hypoxia on AF: A Pulmonary Physiological Perspective - Physician's Weekly

MBRSC to host International Society for Gravitational Physiology meeting – BroadcastProME.com

Abstract submission is now open for the 43rd International Society for Gravitational Physiology Meeting, which will be hosted in the UAE from May 26-31, 2024.

The Mohammed Bin Rashid Space Centre (MBRSC) is set to host the 43rd International Society for Gravitational Physiology (ISGP) Meeting for the first time ever in the Arab world. Scheduled to be held from May 26-31, 2024, at the Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), the event will bring together eminent scientists, representatives from space agencies, young researchers, as well as students.

The meeting aims to foster an exchange of knowledge on the biological and physiological effects of gravity on living organisms. The meeting will not only serve as a collaborative platform, but also be utilised to announce new research and educational opportunities in the field.

Salem Humaid AlMarri, Director General, MBRSC, said: Hosting the 43rd ISGP Meeting is a significant milestone in our continuous efforts to foster knowledge sharing and scientific collaboration. This event aligns perfectly with our commitment to enhancing the understanding of space and its impact on life. By bringing together leading experts in gravitational physiology, we aim to further the boundaries of space science research and education, contributing substantially to the local and global scientific community. We are grateful to our partners at MBRU for partnering on this event. The university has collaborated on numerous projects, including on experiments for astronaut Sultan AlNeyadi during his historic mission aboard the International Space Station. It is through such collaborations that we can truly unlock the potential of space and its profound effects on human health, driving innovation and discovery in the space sector. We look forward to gaining new insights into the world of gravitational science through this meeting and hope it fosters a culture of scientific excellence and exploration, ultimately contributing to the progress of humanity and our understanding of the universe.

Dr Amer Sharif, Chief Executive Officer of Dubai Health and President of MBRU, added: We are proud to be part of the 43rd ISGP meeting which will be held at MBRU. This event is an excellent opportunity for our students, to learn, network and gain insights into the impact of gravity on physiological processes and enhance their understanding of human health in different gravitational environments. Such scientific events perfectly align with our missions at MBRU and Dubai Health. Our integrated academic health system places a strong emphasis on lifelong learning, as we are very much committed to ensuring that our learners are fully equipped with the knowledge and skills needed to contribute to the local and global scientific community, ultimately advancing health for humanity. We are very thankful to our friends at the Mohammed Bin Rashid Space Centre who afforded this opportunity to our students, which is truly unique as it is the first meeting of its kind in the Arab world. We look forward to the insightful discussions, learnings and new research that will emerge from this gathering.

The ISGP association, established in 1979, has a rich history of promoting scientific knowledge on gravitys effects on living organisms and encouraging public and academic interest in this field. Hosting the event in the UAE symbolises the growing stature of the nation in the international science community, providing an opportunity for the UAE science community to engage with global experts, promote the latest findings, including those of Sultan AlNeyadis research projects during his six-month mission on the International Space Station (ISS), as well as the opportunity to highlight the countrys participation in Analog simulation missions.

Pr.Marc-Antoine Custaud, President of ISGP, stated: We are very pleased to announce that our 43rd annual ISGP meeting will be held in Dubai and hosted by MBRSC. This will be an important event for all international researchers working in the field of space physiology, providing a wonderful opportunity to meet each other. The meeting is already shaping up to be a great success.

Abstract submissions for the 43rd ISGP Meeting are now open, while registrations will be opened in February 2024.

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MBRSC to host International Society for Gravitational Physiology meeting - BroadcastProME.com

If anxiety is in my brain, why is my heart pounding? A psychiatrist explains the neuroscience and physiology of fear – PsyPost

Heart in your throat. Butterflies in your stomach. Bad gut feeling. These are all phrases many people use to describe fear and anxiety. You have likely felt anxiety inside your chest or stomach, and your brain usually doesnt hurt when youre scared. Many cultures tie cowardice and bravery more to the heart or the guts than to the brain.

But science has traditionally seen the brain as the birthplace and processing site of fear and anxiety. Then why and how do you feel these emotions in other parts of your body?

I am a psychiatrist and neuroscientist who researches and treats fear and anxiety. In my book Afraid, I explain how fear works in the brain and the body and what too much anxiety does to the body. Research confirms that while emotions do originate in your brain, its your body that carries out the orders.

While your brain evolved to save you from a falling rock or speeding predator, the anxieties of modern life are often a lot more abstract. Fifty-thousand years ago, being rejected by your tribe could mean death, but not doing a great job on a public speech at school or at work doesnt have the same consequences. Your brain, however, might not know the difference.

There are a few key areas of the brain that are heavily involved in processing fear.

When you perceive something as dangerous, whether its a gun pointed at you or a group of people looking unhappily at you, these sensory inputs are first relayed to the amygdala. This small, almond-shaped area of the brain located near your ears detects salience, or the emotional relevance of a situation and how to react to it. When you see something, it determines whether you should eat it, attack it, run away from it or have sex with it.

Threat detection is a vital part of this process, and it has to be fast. Early humans did not have much time to think when a lion was lunging toward them. They had to act quickly. For this reason, the amygdala evolved to bypass brain areas involved in logical thinking and can directly engage physical responses. For example, seeing an angry face on a computer screen can immediately trigger a detectable response from the amygdala without the viewer even being aware of this reaction.

The hippocampus is near and tightly connected to the amygdala. Its involved in memorizing what is safe and what is dangerous, especially in relation to the environment it puts fear in context. For example, seeing an angry lion in the zoo and in the Sahara both trigger a fear response in the amygdala. But the hippocampus steps in and blocks this response when youre at the zoo because you arent in danger.

The prefrontal cortex, located above your eyes, is mostly involved in the cognitive and social aspects of fear processing. For example, you might be scared of a snake until you read a sign that the snake is nonpoisonous or the owner tells you its their friendly pet.

Although the prefrontal cortex is usually seen as the part of the brain that regulates emotions, it can also teach you fear based on your social environment. For example, you might feel neutral about a meeting with your boss but immediately feel nervous when a colleague tells you about rumors of layoffs. Many prejudices like racism are rooted in learning fear through tribalism.

If your brain decides that a fear response is justified in a particular situation, it activates a cascade of neuronal and hormonal pathways to prepare you for immediate action. Some of the fight-or-flight response like heightened attention and threat detection takes place in the brain. But the body is where most of the action happens.

Several pathways prepare different body systems for intense physical action. The motor cortex of the brain sends rapid signals to your muscles to prepare them for quick and forceful movements. These include muscles in the chest and stomach that help protect vital organs in those areas. That might contribute to a feeling of tightness in your chest and stomach in stressful conditions.

The sympathetic nervous system is the gas pedal that speeds up the systems involved in fight or flight. Sympathetic neurons are spread throughout the body and are especially dense in places like the heart, lungs and intestines. These neurons trigger the adrenal gland to release hormones like adrenaline that travel through the blood to reach those organs and increase the rate at which they undergo the fear response.

To assure sufficient blood supply to your muscles when theyre in high demand, signals from the sympathetic nervous system increase the rate your heart beats and the force with which it contracts. You feel both increased heart rate and contraction force in your chest, which is why you may connect the feeling of intense emotions to your heart.

In your lungs, signals from the sympathetic nervous system dilate airways and often increase your breathing rate and depth. Sometimes this results in a feeling of shortness of breath.

As digestion is the last priority during a fight-or-flight situation, sympathetic activation slows down your gut and reduces blood flow to your stomach to save oxygen and nutrients for more vital organs like the heart and the brain. These changes to your gastrointestinal system can be perceived as the discomfort linked to fear and anxiety.

All bodily sensations, including those visceral feelings from your chest and stomach, are relayed back to the brain through the pathways via the spinal cord. Your already anxious and highly alert brain then processes these signals at both conscious and unconscious levels.

The insula is a part of the brain specifically involved in conscious awareness of your emotions, pain and bodily sensations. The prefrontal cortex also engages in self-awareness, especially by labeling and naming these physical sensations, like feeling tightness or pain in your stomach, and attributing cognitive value to them, like this is fine and will go away or this is terrible and I am dying. These physical sensations can sometimes create a loop of increasing anxiety as they make the brain feel more scared of the situation because of the turmoil it senses in the body.

Although the feelings of fear and anxiety start in your brain, you also feel them in your body because your brain alters your bodily functions. Emotions take place in both your body and your brain, but you become aware of their existence with your brain. As the rapper Eminem recounted in his song Lose Yourself, the reason his palms were sweaty, his knees weak and his arms heavy was because his brain was nervous.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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If anxiety is in my brain, why is my heart pounding? A psychiatrist explains the neuroscience and physiology of fear - PsyPost

Renowned Researcher in Physiology to Chair UVA’s Department of … – UVA Health Newsroom

The School of Medicine has recruited Ling Qi, PhD, a leading researcher in protein folding and degradation, to lead its Department of Molecular Physiology and Biological Physics.

Dr. Qi brings incredible expertise as a scientist in understanding how protein degradation within an area of our cells called the endoplasmic reticulum causes disease, together with a selfless, inclusive leadership style and a passion for mentorship and education, saidMelina R. Kibbe, MD, the dean of the UVA School of Medicine and chief health affairs officer for UVA Health. His vision to support groundbreaking discoveries in the department meshes perfectly with ourstrategic planfor the School of Medicine and UVA Health.

Qi comes to UVA from the University of Michigan Medical School, where he has served as a professor in the Department of Molecular & Integrative Physiology and the Department of Internal Medicine since 2016. He has served as president of the Chinese American Diabetes Association, chair of a National Institutes of Health study section and chair of the Biomedical Council at University of Michigan Medical School. He received the Scientific Achievement Award from the Chinese American Diabetes Association, career development and junior faculty awards from the American Diabetes Association and the Bio-Serv Award from the American Nutrition Society. He was elected as a fellow of the American Association for the Advancement of Science in 2021.

Qi has brought in more than $20 million in research over his career and has co-authored more than 70 peer-reviewed publications. His laboratory has uncovered the importance of how the breakdown of proteins within an area of our cells called the endoplasmic reticulum affects many aspects of physiological process and contributes to diseases such asdiabetes, obesity and neurological disorders.

As an educator, Qi has trained more than 50 undergraduate students, 22 graduate students and 27 postdoctoral fellows. During his tenure at Cornell University where he spent nine years before joining the University of Michigan Qi earned the State University of New York Chancellors Award for Excellence in Teaching, a top award for the states best teachers, in 2014.

The Department of Molecular Physiology and Biological Physics has an exceptionally strong foundation and an outstanding team of investigators, and I look forward to seeing how Dr. Qi can energize and inspire the department to continue its outstanding track record of scientific breakthroughs, Kibbe said.

Qi earned his bachelors degree from Fudan University in Shanghai, China, and his PhD from the University of Maryland Baltimore County. He also completed fellowships at Johns Hopkins University and the Salk Institute before joining Cornell University.

I will devote myself unconditionally to build on the departments strengths, tirelessly recruit and retain the best people and advocate for all faculty, staff, and trainees, Qi said. I am looking forward to learning from this great community at UVA Health and improving myself by working closely with my colleagues and the health systems leaders.

Qi will begin his tenure as chair on September 1, 2023. He succeeds Lukas Tamm, PhD, who has served as chair of the department since 2018.

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Renowned Researcher in Physiology to Chair UVA's Department of ... - UVA Health Newsroom

Research Fellow (Aging and Cancer Stem Cell Laboratory … – Times Higher Education

Job Description

The National University of Singapore invites applications for Research Fellow under Aging and Cancer Stem Cell Laboratory in the Department of Physiology, Yong Loo Lin School of Medicine.

We have a deep interest in identifying genes and pathways that are crucial for normal and cancer brain stem cell function, as such studies have implications in regenerative medicine and cancer. Appointments will be made on a one-year contract basis, with the possibility of extension with good performance.

Purpose of the post

The Research Fellow (RF) will be responsible to, and work closely with the Principal Investigator and study team members to ensure the successful completion of the experiments on time. The RFs principal role will be to design and execute experiments, analyze data, write manuscripts and manage experimental protocols.

Main Duties and Responsibilities

The Research Fellow (RF) will be conducting research related to brain stem cell function in the normal brain and during malignancy. The RF will be able to:

Qualifications

The applicant should possess:

Remuneration will be commensurate with the candidates qualifications and experience.

Only shortlisted candidates will be notified.

More Information

Location: Kent Ridge CampusOrganization: Yong Loo Lin School of MedicineDepartment : PhysiologyEmployee Referral Eligible: NoJob requisition ID : 20169

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Research Fellow (Aging and Cancer Stem Cell Laboratory ... - Times Higher Education

Erratum. Integrated Physiology of the Exocrine and Endocrine … – Diabetes Journal

Citation

Teresa L. Mastracci, Minoti Apte, Laufey T. Amundadottir, Alexandra Alvarsson, Steven Artandi, Melena D. Bellin, Ernesto Bernal-Mizrachi, Alejandro Caicedo, Martha Campbell-Thompson, Zobeida Cruz-Monserrate, Abdelfattah El Ouaamari, Kyle J. Gaulton, Andrea Geisz, Mark O. Goodarzi, Manami Hara, Rebecca L. Hull-Meichle, Alexander Kleger, Alison P. Klein, Janel L. Kopp, Rohit N. Kulkarni, Mandar D. Muzumdar, Anjaparavanda P. Naren, Scott A. Oakes, Sren S. Olesen, Edward A. Phelps, Alvin C. Powers, Cherie L. Stabler, Temel Tirkes, David C. Whitcomb, Dhiraj Yadav, Jing Yong, Norann A. Zaghloul, Stephen J. Pandol, Maike Sander; Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433448. Diabetes 2023; db23er08. https://doi.org/10.2337/db23-er08

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Erratum. Integrated Physiology of the Exocrine and Endocrine ... - Diabetes Journal

Survey on Value of Flight Nursing Certification Featured in New Air Medical Journal Research Article – Yahoo Finance

Nearly 1,000 RNs working in the demanding, complex and high-stakes flight care environment said flight physiology and flight nursing clinical knowledge, confidence, and a sense of pride and accomplishment are top benefits of holding the CFRN flight nursing specialty certification. Air Medical Journal publisher Elsevier has made the original research article available for free access through 2023 in honor of the CFRN's 30th anniversary.

OAK BROOK, Ill., May 4, 2023 /PRNewswire-PRWeb/ -- According to a survey of nearly 1,000 registered nurses caring for critically ill or injured patients in the uniquely demanding, complex and high-stakes flight environment, flight nurses earn the Certified Flight Registered Nurse (CFRN) nursing specialty certification "to validate their clinical and patient care excellence, prepare themselves for the flight transport environment, for a competitive hiring advantage, and to lead by example."

The 2022 Certified Flight Registered Nurse Pulse Survey, whose findings appear in a new, peer-reviewed Air Medical Journal original research article, is the first value of certification study of the CFRN flight nursing specialty credential. The CFRN was introduced by the Board of Certification for Emergency Nursing (BCEN) in July 1993. Today, there are over 5,700 CFRNs worldwide.

To earn the complex and multifaceted CFRN credential, nurses must pass a rigorous exam whose content spans clinical knowledge and professional issues specific to air medical transports, as well as safety, survival, disaster preparedness, scene operations management, communications, and equipment and aircraft knowledge.

"As the air medical transport community prepares to mark a milestone in our commitment to excellence, safety, and advancing patient care with the upcoming 30-year anniversary of flight nursing specialty certification, Air Medical Journal is pleased to present this important research," said Air Medical Journal co-editor Eric R. Swanson, MD, FACEP, University of Utah School of Medicine, Division of Emergency Medicine, Salt Lake City, Utah.

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According to the CFRN-certified nurses who responded to the BCEN survey:

The top perceived benefits of being a CFRN are a sense of accomplishment and pride (91%), flight physiology knowledge (85%), flight nursing clinical knowledge (83%), and confidence as a flight nurse (81%).

Since 2012, the annual number of initial CFRN certifications has increased an average of 22%, contributing to a fourfold increase in annual initial CFRN certifications from 2012-2022.

35% have over 10 years of flight nursing experience.

43% are employed by a stand-alone transport program, and another 25% work for a university/academic hospital or university/academic trauma program.

70% of their time is spent in rotor-wing aircraft and 21% in fixed-wing aircraft.

The majority of their patients (49%) are adults aged 18-65, followed by adults over 65 years old (35%), with smaller percentages of pediatric and neonatal patients.

"Flight nurses must safely provide appropriate, timely, and evidence-based care for patients of all ages in a highly autonomous, dynamic environment," said article co-author and BCEN CEO Janie Schumaker, MBA, BSN, RN, CEN, CENP, CPHQ, FABC. "CFRN certification independently validates their advanced clinical and operational knowledge across all aspects of flight nursing, and the renewal process provides an invaluable framework to ensure their flight nursing expertise remains current and relevant over time."

RNs responding to BCEN's CFRN Pulse Survey in October and November 2022 evaluated the CFRN across 13 value of certification categories and shared nursing career and practice environment demographics, transport mode and patient population types, benefits of CFRN certification during the COVID-19 pandemic, and reasons for earning the CFRN.

Findings from BCEN's companion survey on certification in the ground transport setting, The 2022 Certified Transport Registered Nurse Survey, appeared in the January/February 2023 issue of Air Medical Journal (available via free access).

"This CFRN certification study, in combination with the recent critical care ground transport companion study, provides important insight into what flight and critical care transport nurses perceive as benefits of advanced certification, and how holding a mode-specific transport credential validates their dedication to safety, professionalism, and patient care excellence in the out-of-hospital environment," said article co-author Jacqueline C. Stocking, PhD, MBA, MSN, NEA-BC, CMTE, CEN, CFRN, FP-C, CCP-C, RN, NREMT-P, University of California Davis Medical Center, Sacramento, California. Stocking is a long-time editor of Air Medical Journal; her co-editor conducted the editorial process for this article.

About BCEN Founded in 1980, the independent, not-for-profit Board of Certification for Emergency Nursing (BCEN) offers robust nursing specialty certification programs fostering empowered nurses across the emergency spectrum who contribute noticeably to patient care, safety and outcomes. Over 59,000 BCEN credentials are held by RNs and advanced practice RNs who specialize in emergency, flight, critical care ground transport, pediatric emergency and trauma nursing. BCEN offers the Certified Emergency Nurse (CEN), Certified Flight Registered Nurse (CFRN), Certified Pediatric Emergency Nurse (CPEN), Certified Transport Registered Nurse (CTRN) and Trauma Certified Registered Nurse (TCRN) certification programs.

About Air Medical Journal Air Medical Journal (AMJ) is the official journal of the five leading air medical transport associations in the United States: the Association of Air Medical Services, Air Medical Physician Association, Air & Surface Transport Nurses Association, National EMS Pilots Association, and International College of Advanced Practice Paramedics. Published by Elsevier, AMJ is the premier provider of information for the medical transport industry, addressing the unique concerns of medical transport physicians, nurses, pilots, paramedics, emergency medical technicians, communication specialists, and program administrators.

# # #

Media Contact

Hilde Marnul, Board of Certification for Emergency Nursing, 630-352-0811, hmarnul@bcen.org

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Survey on Value of Flight Nursing Certification Featured in New Air Medical Journal Research Article - Yahoo Finance

Positive Relationships Can Keep You Healthy – Medscape

The way you feel about your close relationships may have an impact on your physical health, according to research conducted by the University of Auckland in New Zealand.

Both positive and negative experiences in our relationships contribute to the way our bodies function, including our daily stress, coping, and physiology, like blood pressure and heart rate reactivity.

On average, people with more positive experiences and fewer negative experiences reported lower stress, better coping, and lower systolic blood pressure reactivity, leading to better physiologic functioning in daily life.

Experiencing daily ups and downs in negative relationship experiences, like conflict, were especially predictive of outcomes like more stress, less coping, and overall higher systolic blood pressure.

The COVID-19 pandemic has created considerable strain, turbulence, and variability in people's relationships and may indirectly alter stress, coping, and physiology in daily life, all of which have important implications for physical well-being.

Researchers cautioned that other physiologic states, such as neuroendocrine or sympathetic nervous system responses, should be taken into account as outcomes of daily positive and negative relationship experiences.

This is a summary of the article, "The Good, the Bad, and the Variable: Examining Stress and Blood Pressure Responses to Close Relationships," published in Society for Personality and Social Psychology on March 27, 2023. The full text can be found here.

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Positive Relationships Can Keep You Healthy - Medscape