Category Archives: Physiology

Organovo (ONVO) Publishes Data Describing Physiology of 3D Bioprinted Human Kidney Tissues for Drug Toxicity … – StreetInsider.com

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Organovo Holdings, Inc. (NASDAQ: ONVO) (Organovo), a three-dimensional biology company focused on delivering scientific and medical breakthroughs using its 3D bioprinting technology, today announced the publication of data in Frontiers in Physiology showing the companys 3D bioprinted proximal tubule tissue model exhibits key characteristics of renal physiology that allow for in vitro kidney toxicity testing.

Traditional preclinical models often fall short in their ability to inform clinical outcomes accurately, largely due to the limited functionality of simple in vitro models and species differences, said Dr. Sharon Presnell, chief scientific officer, Organovo. Our newly published data demonstrate that Organovos 3D bioprinted human kidney tissue has great potential to assess the toxic effects of compounds and the development and progression of complex, multicellular processes such as fibrosis.

Key findings and attributes described in the publication include the following:

In addition to the kidney publication, the Company noted a recent article published in ILAR Journal. The publication explores new technologies that could reduce both dependency on animal models and occurrence of liver toxicity in clinical trials. The article, written by scientific executives and experts from the Food & Drug Administration (FDA), Merck & Co., Inc and LifeNet Health, provides a thorough review of human tissue models and how they can accelerate drug development across all discovery stages, including Organovos 3D bioprinted liver model.

The authors reference Organovos technology as a significant innovation in the study of drug-induced liver injury, as it addresses many of the shortcomings associated with traditional in vitro culture models and animal models. They also state that 3D bioprinted tissues exhibit a broad range of highly differentiated in vivo like features and functions.

The authors reference results from Organovos drug-induced liver injury studies that have shown very good reproducibility and concordance with observed outcomes in vivo at the functional and histological levels and that treatment of the bioprinted human liver model with known fibrotic agents mimicked closely that of patient liver samples with drug-induced fibrosis.

Both liver and kidney drug toxicities are significant challenges for pharmaceutical companies working to advance safe and effective therapeutics, said Mr. Keith Murphy, CEO, Organovo. Previous validation data of our 3D bioprinted human liver tissue, combined with the data published in the peer-reviewed journal, Frontiers of Physiology, on our 3D bioprinted kidney proximal tubule tissue, clearly show that Organovos technology can address the unmet needs of our pharma customers and partners by providing timely, cost-effective, and more accurate human tissue models for evaluating drug toxicity and drug-induced fibrotic disease.

Organovos publication titled 3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing, was published online on February 15, 2017 and can be found on the journals website: http://journal.frontiersin.org/article/10.3389/fphys.2017.00123/abstract

The review titled The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development, was published December 31, 2016 and can be found on the journals website: https://academic.oup.com/ilarjournal/article-abstract/57/2/186/2806701/The-Promise-of-New-Technologies-to-Reduce-Refine

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Organovo (ONVO) Publishes Data Describing Physiology of 3D Bioprinted Human Kidney Tissues for Drug Toxicity ... - StreetInsider.com

The physiology of a defeated Shahjahanabad – Livemint

At the end of 1862, the Jama Masjid was handed over to a committee elected by the majority of the Muslim inhabitants, but they were made to sign an agreement which, among other duties, required them to report any use of seditious language. The rules to be enforced in the mosque were also set down by the government, (and) included the clause that European officers and gentlemen civil and military can enter without restriction as to shoes. The Red Fort was now occupied by the army, and lived in by many British officials and their families. Indians could enter only by paying a fee, and were let in to attend the gora bazaars, which were events modelled on the meena bazaars, or womens bazaars, of Mughal times.

The city was slowly rebuilt along new lines. On the northern side of Chandni Chowk, in the place where Jahanaras sarai had stood, the Town Hall was built between 1860-65, out of provincial funds and subscriptions. It was originally known as the Lawrence Institute, after John Lawrence, the Lieutenant Governor of Punjab Province. It housed a chamber of commerce, (a) literary society and museum. In 1866, it was bought over by the municipality and became the Town Hall. The garden north of Chandni Chowk was re-landscaped and renamed Queens Garden. It included a cricket ground, a bandstand, and a menagerie containing various animal species. South of it, in the middle of Chandni Chowk, a clock tower was built. The Mughal-era hammam had been demolished, and where it had stood, was now one end of a new road, officially named Egerton Road, but popularly called Nai Sarak. In the Kotwali Chowk, a new fountain was builtthe phawwara, which in time led to the square being popularly called Phawwara Chowk or fountain chowk. The channel of water that had flowed along the middle of the street was bricked over.

The railways came to Delhi, the first train steaming in on New Years Eve 1867. The railway line was built across the northern half of the city, cutting the city in two. It necessitated the demolition of many houses, the owners of which were compensated with property confiscated after the Revolt. The railways had a positive impact on the trade passing through Delhi. Prosperity increased, at least among the trading class. Between 1868 and 1869, the total tax collected from the bankers, piece goods merchants, grain merchants and traders in food in Delhi district doubled.

That some of the gaiety had returned to the city was noted by a visitor from Calcutta in 1866Bholanath Chander. He visited Shahjahanabad during Diwali, and noted the illumination, and the exhibition of dolls, toys and confectionary and the whole street lighted up by little glass lamps, cherags, and candles. He also remarked that the Mahomedans now fully enjoy the Hindoo festival, though in the mistaken belief that at one time they had not.

While the traders had prospered, the old, mainly Muslim, aristocracy had been impoverished. Many were reduced to manual work, or poorly paid jobs as schoolteachers. Many of them, along with the other poorer population, lived on the fringes of the city along the city wallsMori Gate, Ajmeri Gate, Turkman Gate, Delhi Gate and Khidki Farrashkhana. Former noblewomen were reduced to spinning gota for a subsistence. Famines in the 1860s further compounded the problem by pushing up food prices.

After the revolt, the city had been placed under martial law. In 1861, it came back to civil administration, but under the Punjab Province rather than the North-Western Provinces, to which it had earlier belonged. The municipality, inaugurated in 1863, became an important agency for the civil management of the city. Not surprisingly, the municipal commissioners were mostly members of the mercantile eliteprominent Hindu and Jain merchants, who had supported the British cause during the Revolt. Among the few Muslim members of the municipality was Mirza Illahi Baksh, a member of the royal family, who had covertly helped the British during 1857, and his son. The municipal council was essentially a conservative body with a limited role; through the 1860s, 75 per cent of municipal expenditure was spent on the police.

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The 1860s-70s was a time when a number of schools, including girls schools, were opened with the efforts of both Hindus and Muslims. The Anglo-Arabic School was set up in 1872, and was housed in Ghaziuddin Madrasa from 1889. The Anglo-Sanskrit School was established in 1869, in a haveli donated by Lala Chunna Mal near Katra Neel in Chandni Chowk and financed by him. The Delhi College had been reduced to the status of a high school after the revolt, which it remained till 1864, when college level classes were started. The college, though it had not recovered from the damage done to its library and laboratories during 1857, still enjoyed a good reputation. It therefore came as a shock when, in 1877, the government announced that the college classes would be shifted to Lahore College.

"An indirect effect of the Durbar was that it drew to Delhi people who would have a long-term effect on the city."-

Ironically this announcement was made in the wake of the Imperial Assemblage, or Durbar of 1877, held in Delhi, by which it was hoped to show the British sovereigns interest in this great Dependency of Her Crown, and Her Royal confidence in the loyalty and affection of the Princes and People of India.

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For the people of Shahjahanabad, the Durbar had limited meaning. The Durbar site was well outside the city walls. Even during the Viceroys one procession through the city, the streets were lined with soldiers, who effectively insulated the cavalcade from the people. As a concession to the people of Delhi, two mosques, the Zinat-ul-Masajid and the Fatehpuri Masjid, which had been confiscated after the revolt, were reopened for worship. An indirect effect of the Durbar was that it drew to Delhi people who would have a long-term effect on the city. Dayanand Saraswati, the founder of the Hindu reform movement, the Arya Samaj, visited Delhi for the Durbar. As a direct outcome of the visit, a branch of the Samaj was formed here the following year. Around the same time, a branch of the Theosophical Society, a neo-Hindu movement, too, was established.

From the second half of the 1870s, there began a phase of increased sectarian activity and conflict. Active proselytization, based on public preaching at bazaars by Christian missionaries, had been going on since soon after the Revolt. Soon, there was a mushrooming of sectarian organizations. Apart from the new movements such as the Theosophical Society and the Arya Samaj, orthodox Hinduism was represented by the establishment of the headquarters of the Bharat Dharam Mahamandal, and the Sanatan Dharam Sabha in the 1890s.

There was also a host of purely local Hindu bodies that sprang up in the 1880s and 90s, many of which were caste-based. In 1878 a Jain Sabha was set up in Dharampura locality, adjoining Dariba, presumably as a response to the Arya Samaj. Among the Muslims, the Anjuman-e-Islamia, founded in 1875, performed the role of promoting the interests of Muslims.

The negative side of the increasing assertion of religious identity were sectarian riots. These conflicts afflicted the city on several occasions during the 1880s and 90s, and centred around issues such as cow-protection and rival religious processions. The latter included conflict between Jains and Hindus. The issue of proselytization and conversion also caused conflict between Christian missionaries, Muslims, Arya Samajis and Sanatan Hindus.

The constructive outcome of these sectarian movements was the founding of educational institutions. Two among these stand out in particular. St Stephens College was founded in 1881 by the Cambridge Mission. With humble beginnings in a haveli just off Kinari Bazaar, it soon got a new building near Kashmiri Gate. In 1899, Hindu College was established to provide an education on Sanatanist Hindu lines. The college received financial backing from Kishen Das Gurwala, and was set up in Kinari Bazaar. Then Lala Sultan Singh sold some property in Kashmiri Gate to the college, and it came to occupy a spot just across the road from St Stephens.

Despite religious disputes that cropped up from time to time, the people of Delhi were able to overcome their differences in times of greater trouble. The famine of 1898-1900 and the subsequent plague scare brought various communities together, and this solidarity was expressed by Hindus greeting Muslims emerging from the Jama Masjid after Eid, members of the two communities accepting water from each other, and Muslims participating in Holi celebrations.

This is an edited excerpt from the chapter The Revolt And Its Aftermath in Swapna Liddles book Chandni Chowk: The Mughal City Of Old Delhi.

*****

Swapna Liddles Old Delhi secrets

A haveli that hosted Nehrus baraat and the mosque Shah Jahans wife built

Kucha Pati Ram: In a city that has become increasingly commercial in its land use, it is refreshing to see some streets that are still predominantly residential. The houses of this neighbourhood, just off Hauz Qazi, are beautiful, some with richly carved traditional doorways and balconies, others with equally rare though not so old, Art Deco-inspired doorways in terrazzo. In nearby Gali Prem Narayan is the ruined Haksar haveli where the Nehru baraat stayed during the wedding of Jawaharlal and Kamala Nehru.

Fatehpuri Masjid: Few visitors go to Fatehpuri Masjid, commissioned by Fatehpuri begum, one of the wives of Mughal emperor Shah Jahan. After the revolt, it remained closed for 20 years. It was restored for worship in 1877, as a boon of the Delhi Durbar. The spacious courtyard does not have the impo-sing grandeur of the Jama Masjid, but is in a more human, intimate scale. Stepping into it from the bustle of the bazaar outside, one is suddenly in an oasis of peace. The attached public library is an added attraction for those wanting to research the history of the city and more.

First Published: Fri, Feb 17 2017. 02 27 PM IST

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The physiology of a defeated Shahjahanabad - Livemint

Human Anatomy Coloring Study Muscular System Physiology Learning Book Launched – MENAFN.COM

(MENAFN Editorial) A new human body coloring book has launched, aimed at those in the medical field or working with the human body on a professional or educational basis. Students who have to take anatomy and physiology tests will know that the muscular system is one of the most difficult sections to learn, and it's because of this that the new coloring book has been launched.

More information can be found at: https://youtube.com/watch?v=5Wr32A1oJB0.

One of the things that makes the anatomy and physiology test so hard is that people have to learn the location and names of between 640 to 850 muscles in the human body. Using the new coloring book, customers can master the muscular and benefit from realistic medical anatomy.

The realism behind the drawings in the book can help the reader to master the muscular system while they are enjoying coloring the different detailed sections of the human body. Once the drawings have been colored in, they can then be compared with the labeled version, which is also available to color.

This meansthat people using the coloring book can learn the human anatomy and physiology of the body while coloring to boost their knowledge and gain a better understanding of the muscular system.

Because each customer will spend a while on each section of the human body, the repetitive and methodical nature of coloring in the book helps to promote learning and allow the names and muscles to stick in the mind.

Coloring will improve the study ability of each customer, as well as helping to improve reference recall by fixating the anatomical images in their mind for easy visual recall later on simply through coloring the body parts in the book.

Through coloring the book, customers can imprint the different shapes and the location of each muscle on their mind, helping them to recall them later on when they need to. This interactive approach means people don't have to spend hours memorizing muscles on their own.

Full details can be found by visiting the URL above.

MENAFN2002201700703206ID1095256480

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Human Anatomy Coloring Study Muscular System Physiology Learning Book Launched - MENAFN.COM

Unwrapping the Physiology of a Tour de France Champion – Newswise (press release)

Newswise Given the current spotlight on sport concerning the use and abuse of Performance Enhancing Drugs (PEDs), there is a public interest in athletes providing greater transparency with regard to what makes them elite. In this study, the investigators conducted a thorough examination into the physiological characteristics of a two-time Tour de France champion cyclist. Several interesting results were found including: 1) some of the highest aerobic capacity values in a cyclist on record; 2) high cycling efficiency; and 3) a higher than anticipated body fat percentage. Collectively, the data demonstrated what may be the required physiological characteristics to be a Tour de France champion. While the data can neither confirm nor deny the use of PEDs, it is perhaps a step in the right direction to publicly demonstrate the type of physiology required to be one of the greatest endurance athletes in the world. For more information, view the abstract or contact the investigator.

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Unwrapping the Physiology of a Tour de France Champion - Newswise (press release)

Human Anatomy Coloring Study Muscular System Physiology Learning Book Launched – Satellite PR News (press release)

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Students, scientists and people working on the human body can now memorize muscle location and names through a new coloring book. The book helps to build a better understanding of muscle location and the human anatomy.

Colorado Springs, United States February 14, 2017

A new human body coloring book has launched, aimed at those in the medical field or working with the human body on a professional or educational basis. Students who have to take anatomy and physiology tests will know that the muscular system is one of the most difficult sections to learn, and its because of this that the new coloring book has been launched.

More information can be found at: https://youtube.com/watch?v=5Wr32A1oJB0.

One of the things that makes the anatomy and physiology test so hard is that people have to learn the location and names of between 640 to 850 muscles in the human body. Using the new coloring book, customers can master the muscular and benefit from realistic medical anatomy.

The realism behind the drawings in the book can help the reader to master the muscular system while they are enjoying coloring the different detailed sections of the human body. Once the drawings have been colored in, they can then be compared with the labeled version, which is also available to color.

This means that people using the coloring book can learn the human anatomy and physiology of the body while coloring to boost their knowledge and gain a better understanding of the muscular system.

Because each customer will spend a while on each section of the human body, the repetitive and methodical nature of coloring in the book helps to promote learning and allow the names and muscles to stick in the mind.

Coloring will improve the study ability of each customer, as well as helping to improve reference recall by fixating the anatomical images in their mind for easy visual recall later on simply through coloring the body parts in the book.

Through coloring the book, customers can imprint the different shapes and the location of each muscle on their mind, helping them to recall them later on when they need to. This interactive approach means people dont have to spend hours memorizing muscles on their own.

Full details can be found by visiting the URL above.

Contact Info: Name: Lloyd Organization: Human Body Coloring Books Address: 7518 Banner Court, Colorado Springs, CO 80920, United States

For more information, please visit https://www.youtube.com/watch?v=5Wr32A1oJB0

Source: PressCable

Release ID: 169642

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Human Anatomy Coloring Study Muscular System Physiology Learning Book Launched - Satellite PR News (press release)

Listen to this male snow leopard’s love song in the Eastern Sayan … – The Siberian Times

Many people still believe that these large secretive cats can't roar due to the physiology of their throat. Picture: Following Snow Leopard Volunteers Expedition

Spotted by a camera trap in the Republic of Buryatia, this snow leopard has debunked the 'no roar' theory about snow leopards, says a leading Russian authority on the wild animals.

Dmitry Medvedev, president of the Irklutsk-based Snow Leopard Foundation, says the mating season cry is proof.

'Many people still believe that these large secretive cats can't roar due to the physiology of their throat, unlike lions, tigers and leopard,' he said.

'This video proves that they can. It shows a large male roaring loudly during a mating season high in the Eastern Sayan mountains.'

Listen to this male snow leopard's love song in the Eastern Sayan mountains.Pictures: Gazeta Pskov, Dmitry Medvedev

The video which hasn't been previously shared was filmed in March 2014 near the snow leopard research base in Buryatia, and won a video trap competition for cats in 2016.

Website snowleopard.org says the endangered animals 'make sounds similar to those made by other large cats, including a purr, mew, hiss, growl, moan, and yowl.

'However, snow leopards cannot roar due to the physiology of their throat, and instead make a non-aggressive puffing sound called a 'chuff'.'

Yet the sound on this video seems more than a 'chuff'.

Endemic to high and rugged mountains in southern Siberia and central Asia, scientists estimate that there may be as few as 3,920 snow leopards left in the wild.

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Listen to this male snow leopard's love song in the Eastern Sayan ... - The Siberian Times

Salivary salt modifies cheese’s tang – Chemistry World (subscription)

If your Christmas was anything like mine, then you ate an awful lot of cheese. I love mature cheddar, and Im partial to brie, but dont offer me anything blue. I always thought my taste buds dictated my choices but recent research has shown that your physiology can affect how you perceive food.

To test for a link between physiology and taste, Elisabeth Guichard from the French National Institute for Agricultural Research, and colleagues combined cheddar, soft cheese, butter, protein powder, salt and water in different proportions to create four model cheeses with differing fat content and firmness. They then trained 14 taste testers to recognise the odour of two specific compounds nonan-2-one, which gives blue cheese its notable smell, and ethyl propanoate, which gives cheese a fruity odour and rate their perception of these two compounds in the cheese they tasted. At the same time the researchers recorded the testers chewing activity and saliva composition.

Chewing mixes food with saliva. During this step, aroma compounds within the food transfer to the saliva and are then released into the nasal cavity. It is already known that food texture and composition will affect this aroma compound release. What Guichard has now discovered is that saliva composition plays a role as well. The aroma of cheeses is perceived differently by humans due to differences in their salivary composition and the way they process the cheese in their mouth. Humans with a low salt content in saliva and high lipolysis [the ability of the body to break down fats in the cheese] activity perceived the cheeses as being more salty, more cheesy and less fruity, says Guichard.

Flavia Gasperi, head of the sensory quality research group at the Edmund Mach Foundation in Italy, agrees with Guichard that both chemical and physiological parameters can influence a foods perceived quality. The highlight of this study is that the researchers are not scared, as often happens, by the complexity of this interaction between food and consumer. They successfully take into account different aspects of food composition and texture, but also the physicochemical and cognitive mechanisms related to the subjects responses, says Gasperi.

Taste perception can also change with time, as eating salty foods alters saliva composition over the course of a day and sense of smell decreases with age. This research could help the food industry tailor their products to the physiology of specific populations. So maybe one day I will like blue cheese, but for now, just pass me the cheddar.

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Salivary salt modifies cheese's tang - Chemistry World (subscription)

UNM Exercise Physiology Lab seeks 30 subjects for weight loss study – UNM Newsroom

The UNM Exercise Physiology Lab is looking for healthy adults ages 18 to 65 years to participate in a weight loss study.

The study involves 12 weeks of health coaching to determine if health devices influence body weight, physical activity levels and select blood-borne markers of health like fasting blood glucose, hemoglobin A1c and insulin.

Participants must have a Body Mass Index (BMI)of greater or equal to 30 BMI kg/m^2, must take less than 7,000 steps per day, and must have and iPhone or Android smart phone.

Those who participate will be randomly assigned to one of two intervention groups, a video conferencing or in-person group or a control group.

The Control group must dedicate 44 hours to the study, twohours for pre and post testing and three and a half hours of MyFitnessPal inputting per week.

The Intervention group must dedicate 54 hours to the study, twohours for pre and post testing, three and a halfhours of MyFitnessPal inputting per week and nine and a half hours of health coaching.

There is no compensation for participating in this study.

For more information, contact Kelly Johnson 505-322-5715 kjohnson4@unm.edu or Dr. Ann Gibson at 505-277-2248 alg@unm.edu.

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UNM Exercise Physiology Lab seeks 30 subjects for weight loss study - UNM Newsroom

41 participants attend NFABD’s physiology course – Borneo Bulletin Online

| Fadhil Yunus |

THENational Football Association of Brunei Darussalam (NFABD) has made efforts to combine sports science in the field of football coaching with a physiology course in collaboration with the High Commission of the Republic of Singapore at the NFABD House which began yesterday.

Morni bin Zakaria, Executive Committee Member of NFABD, said that psychology is a study of the function of body, anatomy, organs and interactions with the environment.

In this case, interactions with physiology is interrelated and also needed in football, the guest-of-honour said during an opening ceremony.

The NFABD executive committee member advised participants to seize the opportunity to comprehend better the benefits which will be presented in the course whether it is in theory or practical.

The three-day physiology course conducted by an established expert in Sports Medicine and Physiology at the Singapore Sports Institute, Dr Abdul Rashid Aziz, will focus on the extensive studies on athletes conditions and training during Ramadhan.

The short course, which ends on Wednesday, also offers a range of theoretical and practical case studies such as Muscles and Energy Systems, Training Principles, Physiological demands in Football, Aerobic and Anaerobic Training, Training Load and many more.

Officials and participants in a group photo. KHAIRIL HASSAN

Morni asserted that the participants can gain insight to Dr Abdul Rashids vast experience and expertise in the field of sports science despite the short length of the course.

He also took the opportunity to express his gratitude to Lim Hong Huai, the High Commissioner of the Republic of Singapore to Brunei Darussalam, for providing cooperation and support to NFABD efforts in bringing in an expert from Singapore.

A total of 41 local head and assistant coaches from the teams in the DST Super and Premier Leagues, physical education coaches from the Ministry of Education, coaches from the Department of Youth and Sports and NFABD staff coaches are currently taking part in the course.

The executive committee member added that it already serves as a great opportunity to the participants as it can be used as well as possible in enhancing their knowledge in the field of coaching as an added value in expanding their own expertise to be applied to football players.

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41 participants attend NFABD's physiology course - Borneo Bulletin Online

American Physiological Society > Physiology – the APS

Physiology publishes invited review articles written by leaders in their fields. These articles are peer reviewed and highlight major advances in the broadly defined field of physiology. The journal also publishes shorter articles that either present important emerging topics and technologies or differing points of view. Finally, the journal highlights and briefly summarizes some of the most exciting new papers in physiology. With a new format that is both exciting and attractive, the journal is a valuable tool for researchers, educators, and students.

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American Physiological Society > Physiology - the APS