Category Archives: Physiology

Physiology

The World’s First | GoMore Unveils a Revolutionary AI Coach for Weight Control with XTERRA, Dyaco – PR Newswire UK

The backbone of XTERRA's smarts to provide tailored exercise routines to consumers is GoMore's AI Coach System. By combining physiological data and diet training-based methodology to build personalized stamina models tailored to each individual, GoMore's AI Coach gives its users guidance according to the weight loss goals they set for themselves. Acting as a private coach that's always there, the AI Coach will provide a personalized schedule when it calculates various training variables such as exercise intensity, duration, frequency and rest time, which in turn optimizes exercisers' performance and calorie burn rate to enhance weight loss efficiency.

With XTERRA's fitness equipment integrated with GoMore's AI Coach, users can now monitor in real-time their physiological data, including how much stamina they have remaining, and aerobic/anaerobic training effects to make sure they are on the right track. The AI Coach system can also automatically change the incline and speed of XTERRA's treadmillsbased on the training sessions it suggests. Furthermore, users can set up and check all workout calendars remotely to get a more holistic view of their training progress anytime with just their mobile devices.

"GoMore AI coach thinks like a real coach. Instead of traditional physiological estimation, we developed our unique stamina model to classify users' capabilities and helped optimize every single training session by controlling long-term fatigue," said Hsin-Fu Kuo, CEO of GoMore.

As the core technology of the stamina model, the patented Stamina Algorithm came from an experimental project that GoMore and a world-class research team at the East Tennessee State University has collaborated with. After three years on the project, GoMore got its validation from presenting two peer-reviewed posters at the American College of Sports Medicine conference. Based on sports science and exercise physiology, the stamina model measures physiological response during training and then generates a personalized stamina model that lets GoMore AI Coach calculate users' stamina reserves in real time.

Come and experience this pioneering technology at XTERRA, Dyaco's booth at booth 218 in hall A6, ISPO Munich Exhibition. GoMore's AI solution will be exhibited to showcase this comprehensive solution in this new era of training.

GoMore Video: https://youtu.be/TiNRCn5zVL0

Contact:

Jun TsengJun.tseng@bomdic.com+886-926-119-255

Photo - https://mma.prnewswire.com/media/1081137/GoMore_AI_Coach_system.jpg

SOURCE GoMore

Read more from the original source:
The World's First | GoMore Unveils a Revolutionary AI Coach for Weight Control with XTERRA, Dyaco - PR Newswire UK

Physiology

Frances CNES calls for long-term collaboration with ISRO on human spaceflight – Economic Times

Jean-Yves Le Gall, president, CNES, Frances national centre for space studies, has called for cooperation between France and India in human spaceflight mission.

He said the CNESs support for the Gaganyaan missions is the first step towards future collaboration on development of Indias planned space station.

The CNES president highlighted how France has acquired more than 40 years of experience in human spaceflight and developed highly sophisticated facilities in this field in Toulouse, such as the CADMOS (centre for the development of microgravity applications and space operations) and the MEDES (space medicine and physiology institute), backed by world-renowned French expertise in space medicine.

Gall, who was the guest of honour at the international Human Spaceflight Symposium organized in Bangalore, said CNES and ISROs teams have finalized drafting of the agreement to provide services at CADMOS and MEDES in collaboration with ESAs European Astronaut Centre (EAC) and potentially at Novespace to conduct experiments and training on parabolic flights aboard the Air Zero G.

We want cooperation between France and India in human spaceflight to evolve into a long-term partnership along the same lines as our 15-year collaboration on climate-monitoring satellites and 50 years working together on launchers, said Gall.

CNES and ISRO had signed an agreement in 2018, when the Gaganyaan programme was first announced, to train Indian flight physicians provide training in France and the use of equipment developed by CNES by the countrys future astronauts.

Read this article:
Frances CNES calls for long-term collaboration with ISRO on human spaceflight - Economic Times

Physiology

French Researchers Discover a New Component in Blood – Gilmore Health News

French researchers discovered the presence of complete and functional mitochondria in the bloodstream. Ultimately, this discovery may lead to better diagnosis, monitoring, and treatment of many diseases, including some cancers.

Blood Cells

Our blood consists of red and white blood cells and platelets bathed in a liquid known as plasma. But the blood is also composed of complete and functional mitochondria researchers at the Inserm of the University of Montpellier and the Montpellier Cancer Institute revealed in a study published on January 19 in The Faseb Journal. These organelles play a key role in maintaining the lipid content and good ion concentrations necessary for physiological communication, in supplying the energy needed for blood circulation, in supporting the transport of glucose and insulin and in eliminating potential health risks.

Read Also: Mitochondrial Damage Can Cause Osteoporosis According to Study

They also have the peculiarity of having their own genome. The genome is transmitted exclusively by the mother and differs from the DNA in the nucleus. Until now, mitochondria have only been found outside cells in special cases, released by platelets into the extracellular space. In the long term, these results, unprecedented in physiology, pave the way for new therapeutic paths.

In the past, research has shown that a healthy persons blood plasma contains up to 50,000 times more mitochondrial DNA than nuclear DNA. To try to detect and quantify it in the blood, the researchers here had the idea of protecting it in a stable structure. Then they analyzed about 100 blood plasma samples.

Using a highly sensitive detection method called genetic amplification, which allows for direct measurement of minimal amounts of DNA, they discovered the presence of structures in the bloodstream that contain the intact, functional mitochondrial genomes. If you look at the high number of extracellular mitochondria we find in the blood, we wonder why this was not discovered earlier, says Professor Alain R. Thierry, who led the research.

Read Also: FIT A New Cancer Self-Test Kit That Can Save Lives

In the blood, these mitochondria could be involved in physiological and/or pathological processes that require communication between cells, such as inflammatory mechanisms, the researchers argue. In particular, recent studies have shown that certain cells can exchange mitochondria, such as stem cells with damaged cells. The extracellular mitochondria could perform various tasks as messengers for the whole body, explains Alain R. Thierry.

Ultimately, this discovery could lead to better diagnosis, monitoring or treatment of certain diseases.

The research team is now investigating the extracellular mitochondria as biomarkers in non-invasive prenatal diagnosis and cancer. Further research is needed to assess the impact and potential implications of this discovery in terms of cellular communication, inflammation and clinical applications, the researchers conclude.

Read Also: Genomic Analysis May Detect Lung Cancer Before It Even Develops

Since mitochondria play a key role in regulating the bodys major metabolic pathways, their destruction or weakening can lead to serious complications such as multiple sclerosis, autism, bipolar disorder, chronic fatigue syndrome, type 2 diabetes, heart disease, and cancer.

When the mitochondrial DNA is altered, the risk of cancer increases. When too many free radicals are produced, mitochondria create oxidative stress that prevents antioxidants from defending the body against cancer. In the past, researchers have found that it is mainly lung, breast and kidney cell carcinomas that have increased as a result of these mutations.

https://onlinelibrary.wiley.com/doi/full/10.1096/fj.201901917RR

Researchers at Baylor College of Medicine Discover How to Improve Bone Repair

NAD Plus An Anti-Aging Supplement Could Play A Big Role in The Treatment of Cancer

The Latest On The Underlying Physiology of Aging

Study Finds New Key To Reverse Wrinkles and Hair Loss

Great Breakthrough in Understanding Mesothelioma a Cancer Caused by Exposure to Asbestos

Garlic and Onions Can Protect from Breast Cancer According to Study

Scientists Are Now Using Viruses to Treat Cancers And, Other Diseases

Recent Study Shows That Lung Cancer Is Under-Recognized in Non Smokers

How Does Cancer Manipulate The Immune System?

Read the original here:
French Researchers Discover a New Component in Blood - Gilmore Health News

Physiology

Hon. Dr. Dale Layman, 2019 Humanitarian of the Year and Founder of Robowatch LLC, Sits Down Again with the Top 100 Registry Inc. for a Spotlight…

PR.com2020-01-23

Joliet, IL, January 23, 2020 --(PR.com)-- The Honorable Dr. Dale Pierre Layman, AS, BS, MS, EdS, PhD #1, PhD #2, Grand PhD in Medicine, MOIF, FABI, DG, DDG, LPIBA, IOM, AdVMed, AGE, is the Founder and President of Robowatch, LLC. (The website is at http://www.robowatch.info) Robowatch is an international non-profit group whose main purpose is to keep a watchful human eye on the fast-moving developments occurring in the fields of robotics, computing and Artificial Intelligence (A.I.) industries.

The Hon. Layman was the very first person in his family to attend college. In 1968, he was awarded an Associate of Science (AS) degree in Life Science, from Lake Michigan College. The same year, he won a Michigan Public Junior College Transfer Scholarship to the University of Michigan in Ann Arbor. In 1971, he received an Interdepartmental B.S. with Distinction, in Anthropology - Zoology, from the University of Michigan. From 1971 to 1972, Layman was employed as a Histological Technician in the Department of Neuropathology, at the University of Michigan Medical School. From 1972 to 1974, he was attending classes and serving as a Teaching Fellow, in the Physiology Department of the U of M Medical School, for which he was awarded an MS, in 1974.

From Fall of 1974 to Spring of 1975, Dr. Layman was hired under the Federal CETA Program, for one year, as an Instructor in the Biology Department, at Lake Superior State College. A major career achievement occurred in the Fall of 1975. It was then, that Dr. Layman was hired as a full-time, permanent Instructor in the Natural Science Department of Joliet Junior College, Joliet, Illinois. He taught Human Anatomy & Physiology, and Medical Terminology, for 32 years full-time, before retiring in 2007. He then returned and taught part-time, from 2008 to 2010. While employed, he wrote six textbooks in his field, was selected as a Notable Author by Text and Academic Authors, and served as a Council Member on their Governing Board.

While he was still teaching at Joliet Junior College, Dr. Layman ardently kept going and going for more schooling. In 1979, he received an Ed.S. (Educational Specialist) degree in Physiology and Health Science, from Ball State University. Dale received his first Ph.D. from the University of Illinois, in Health and Safety Studies, in 1986. In 2003, Dr. Layman received both a second Ph.D., as well as a Grand Ph.D. in Medicine, from the Academie Europeenne D'Informatisation (AEI) and the World Information Distributed University (WIDU). He also holds a Full Professorship in the World Information Distributed University, located in Brussels, Belgium. "Prof. Dale Pierre Layman is the First Grand Doctor of Philosophy in Medicine in the USA," the Grand Doctor's Committee stated. Grand PhD Vorontsov (under Secretary-General of the United Nations), also noted that, "He was the first, who has formulated the global problem: From Homo Sapiens to Robo Sapiens, and he has grounded a danger of this potentially irreversible process to Natural Man."

Dr. Layman has received numerous published accolades over the years, and his biography has appeared in many Who's Who-type publications. For example, in 2018, he was the Cover Feature for the Top 100 Registry of Business Leaders and Professionals. On the cover, he was shown falling into a Deep Black Hole in Cyberspace, clutching a human skull in his right hand, and The Great 2045 "Robo-" Death Clock in his left hand. He implored, "Please Help Us Save Mankind!" This was followed by his 2019 Cover Feature for this distinguished publication, where he was dressed in costume as Elad, the Extra-terrestrial, who begged, "Please Help Us Save Mankind!!!" Elad (Dr. Layman's alter-ego) was praised as Humanitarian Of The Year, and he was featured in a video from the Top 100. Now, in the Year 2020, Layman also appears in a longer video, including Elad, who tells his Tale of Woe, as he is the last surviving member of his race, from the robot-dead Planet, Terra. Additionally, he will be the 2020 Cover Feature.

Most recently, Dr. Layman attended the 40th Annual Economic Outlook (January 22, 2020), sponsored by The Executives' Club of Chicago, at the Hyatt Regency hotel. Before the program, Dr. Layman approached many other attendees and passed out his business cards, while holding up that very morning's issue of USA Today. The front of the Money section flashed this article by Edward Baig: "AI - - 2020 and Beyond: Where AI Is Going." One quote from the article states, "What pretty much everyone agrees on is that AI will make a profound difference through the next decade and beyond, during which we may see a further blurring between human and machine."

Dr. Layman has been taking additional classes at Joliet Junior College - trying to become a polymath - while also earning a second membership in Phi Theta Kappa.

Watch Dr. Layman's Full Interview Here

Contact Information:

Top 100 Registry Inc.

David Lerner

855-785-2514

Contact via Email

http://www.top100registry.com

Read the full story here: https://www.pr.com/press-release/803819

Press Release Distributed by PR.com

Originally posted here:
Hon. Dr. Dale Layman, 2019 Humanitarian of the Year and Founder of Robowatch LLC, Sits Down Again with the Top 100 Registry Inc. for a Spotlight...

Physiology

Wouldn’t have won Nobel Prize if based in India: Abhijit Banerjee – India Today

It isn't that there's no good talent in India, but a certain kind of system is needed, MIT professor and renowned economist Abhijit Banerjee said in Jaipur on Sunday.

Photo: Mail Today

Indian-American economist Abhijit Banerjee says he wouldn't have been able to win a Nobel Prize if he were based in his country of origin.

It isn't that there's no good talent in India, but a certain kind of system is needed, he said today at a literature festival here.

It's not possible for a single individual to achieve it, Abhijit Banerjee said, explaining that a lot of work for which he got credit was done by others.

Born in Mumbai, Abhijit Banerjee was educated at the University of Calcutta and Jawaharlal Nehru University. He received his PhD from Harvard University and is a professor at the Massachussetts Institute of Technology (MIT).

In 2019, he shared the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel with his wife Esther Duflo and Michael Kremer. They were given the award "for their experimental approach to alleviating global poverty.

The prize in economics isn't technically a Nobel. It wasn't established by Alfred Nobel's will, which says his wealth should be distributed to those making contributions to humankind in the fields of physiology or medicine, literature, physics, chemistry and peace.

Nonetheless, the economics prize is among the most coveted honours in the field of economic sciences.

Read this article:
Wouldn't have won Nobel Prize if based in India: Abhijit Banerjee - India Today

Physiology

In the wake of the Fukushima nuclear disaster, some animals are thriving – The Hill

It has been nearly nine years since the Fukushima Daiichi nuclear power plant nuclear disaster, and while people still remain evacuated from the areas most contaminated by radioactivity, many wonder: What happened to the wildlife left behind?

A newly released study by a team of scientists from the University of Georgia and Fukushima University found that years after the disaster at Fukushima, populations of mid-to-large-sized mammals and birds are thriving in the absence of human pressure.

The March 11, 2011, nuclear disaster in Japans Fukushima Prefecture caused by the tsunami that resulted from a massive magnitude-9 earthquake was one of the worst nuclear plant disasters in human history, second only to the 1986 Chernobyl incident in Ukraine.

A wild boar. Courtesy of the University of Georgia.

Through remotely operated, motion-activated cameras placed at 106 sites, researchers saw that some species like raccoons and wild boar were more abundant in the humans excluded zone the most contaminated area people are not allowed to live in when compared to the humans restricted zone where people have returned and the humans inhabited zone that was never evacuated.

The fact that animals seem to be doing well at a population level is counterintuitive. I mean, these are very contaminated landscapes, says James Beasley, the wildlife ecology professor at the University of Georgia who led this project. He says the popular movie or video game perception of abandoned nuclear wastelands is not exactly real life at Fukushima or Chernobyl.

Beasley and the team went to the Fukushima exclusion zone in 2016 to begin this camera study. They set up the cameras across the landscape, including the zone in which people can no longer live because the radiation dose rates are still above the recommended safety threshold.

Even in the most contaminated zones of the field site, Beasley says, it is still safe to set up the cameras if one doesnt linger too long. They wear heavy rubber boots and an alarm that sounds if a certain radiation dose rate is exceeded.

It's okay to put a camera up for a few minutes and then move on. But, you know, that's not the sort of place you want to stop and have your lunch, for example, he adds.

Macaque monkeys. Courtesy of the University of Georgia

Caught on Camera

The observation period lasted for 120 days from 2016 to 2017, and in that time, more than 267,000 photos were captured on the motion-activated cameras. In total, 20 species of mammal and birds were spotted roaming across the three zones surveyed.

Out of all the animals spotted on the cameras, wild boar showed up in the human-excluded zone the most in more than 26,000 of the images to be precise. This is not exactly surprising, Beasley says, because wild boar are opportunistic and reproduce at a high rate. In comparison, wild boar were caught on camera more than 7,200 times in the human-inhabited region during the observation period.

Red foxes, masked palm civets, green pheasant, Japanese macaques, Japanese hares and raccoon dogs were all captured on the cameras. The one lucky camera snap of a baby macaque riding on its mothers back is not just adorable, it is evidence reproduction is happening in this area despite the contamination.

A Japanese serow. Courtesy of the University of Georgia

Timothy Mousseau, a biology professor at the University of South Carolina, was not involved in this study, but also does similar research in Fukushima and Chernobyl. He says the findings in this study reflect what he has seen in his own work in Fukushima: that population-wise, human presence can impact animal abundance more than the radiation effects.

He says the massive clean-up effort of the area was likely a large disturbance for animals in the region. All of this noise and dust and human activity seems to be a much bigger factor shaping the abundance and distribution of the mammals than the radiation effects, says Mousseau.

A hare. Courtesy of the University of Georgia

This study examines the population-level impacts of the disaster and not the molecular-level impacts of radiation. Beasley says while there may not be enough of an impact on physiology or reproduction from the radiation to suppress the population, they will conduct more research on animal health at Fukushima in the future to learn more.

Mousseau did a study on barn swallows in Fukushima shortly after the disaster in 2011 and found they did have genetic damage, but it was minimal. Another study on genetic damage in earthworms and wild boars shows there are molecular impacts of radiation exposure, but these studies need to be continued over time to see if this DNA damage manifests at the population level.

In this case at Fukushima, the inverse correlation of human presence and animal abundance indicates people leaving the area has a positive impact on the rewilding of the landscape, which is similar to findings from longterm wildlife abundance studies in Chernobyl.

Many of the organisms like the birds and insects were pretty dramatically impacted in the first year or two after the accident, Mousseau says. But now, the main message can be optimism.

It's clear that many of these organisms have come back...these areas can self-remediate just by being left alone for a little while.

A badger. Courtesy of the University of Georgia

Read more:
In the wake of the Fukushima nuclear disaster, some animals are thriving - The Hill

Physiology

The Best Wool Socks According to Experts – GearJunkie

On a mission to track down the best pairs of wool socks, we sought help from the pros.

Wool has long been touted as the best material for overall warmth and odor resistance during outdoor pursuits. These pros love their choice wool socks for breathability, comfort, and long lifespans.

From ice climbing and ski mountaineering in the Rockies to polar adventures at the worlds farthest ice caps and running the hardest ultramarathons on the planet, here are the top five best wool socks according to the experts.

Polar adventurer and expedition guide Eric Larsen is the first person in history to complete expeditions to the South Pole, the North Pole, and the Mount Everest summit in a continuous 365-day period. He also accomplished the first-ever summer expedition to the North Pole.

Keeping all 20 digits healthy is pretty important on those self-supported missions in the coldest environments on the planet. The best sock, in Larsens experience, is the Wigwam Ice Sock.

I got my first pair in 2008. Ive had a few pairs since then, but, usually, I get about 2-3 years use out of one pair, he said. That means Larsen wears a single pair on a polar expedition for nearly 2 months straight.

So, in a single year, hell use that pair for 3-5 months of polar travel and training. He prefers the Wigwam for polar expeditions to the North and South poles, teaching his polar training course, crossing the Greenland ice cap you know, common everyday athletic pursuits as well as ice fishing and dog sledding.

They are a simple wool knit that breathes incredibly, he noted. They are a heavier, thick sock, so they provide more insulation than any other sock Ive ever used and are super durable. I dont use them in lightweight hiking boots, but in pack boots and my polar boots they are amazing.

Shop Now

Got cold feet? Use these ten tips from Polar Explorer Eric Larsen to keep your feet warm in the winter and cold weather. Read more

Chantelle Robitaille, an endurance coach at Carmichael Training Systems, recently earned her master of science degree in High Altitude Exercise Physiology. She has also worked as an exercise physiologist and researcher at Colorados Western Colorado University, near where she lives. When shes not doing science, she races 100-mile ultramarathons across the world.

Im a big fan of the Point6 Colorado Mini Crew, said Robitaille, who got the pair as a Valentines Day gift about 4 years ago. The socks are ideal for running, biking, and hiking. She loves them so much that shes since bought a variety of other Point6 socks, including ski and compression.

This is the only brand of wool socks Ive owned that dont get a hole in the big toe within a few wears.They are never too hot or too cold and never get stinky.I even wore a pair of Point6 socks while pacing at Badwater 135 this summer. If a pair of socks can withstand one of the worlds toughest footraces, we approve.

Shop Now

Professional skimo racer and trail runner Cam Smith is based in Crested Butte, Colorado. Hes a member of the U.S. Ski Mountaineering team and a two-time winner of the Grand Traverse Triple Crown.

I havea few pairs of Darn Tough socks that are my absolute go-to all winter long, said Smith. His favorite? Smith uses the Darn Tough Mountain Top Over-The-Calf Cushionfor all types of skiing from alpine to backcountry to nordic.

Theyre warm enough for sitting on chairlifts but light and breathable enough for skinning hard up a mountain. Hell even wear them in the summer on cold mornings while camping or for predawn runs.

The little bit of extra cushion adds comfort, which is nice when youre in ski boots all day. I find theyre great in any cold-weather activity, he said.

Theyre 2 years old and show only a few signs of wear despite being shoved into my ski boots for hours and hours all winter. Darn Tough also has an awesome lifetime warranty, and if I ever needed to I could exchange them at a local shop.

Shop Now

Master bootfitter Sam Tischendorf helps skiers from all over the world hone their ski boot fit at Bootdoctors Telluride and as a national Masterful University Instructor. Shes the only female master bootfitter in the entire United States.

For ski boots, thin, even knitting and consistent thickness around the foot is the most ideal type of sock, she explained. I wear wool socks for everything skiing, snowboarding, running, biking, and kicking around town. My most memorable is a pair of FITS Micro Light. They can get wet but dont irritate my feet or cause friction in my shoes.

Tischendorf got the socks about four summers ago, and they were a staple for her mountain endeavors. They just sprung a hole this summer, so theyre relegated to being worn with boots and jeans, she said.

Shop Now

Dawn Glanc is an AMGA-certified rock and alpine guide. Specializing in mixed and ice terrain, veteran Glanc has been a professional climber for more than 20 years. A resident of Ouray, Colorado, shes among the earliest wave of female ice climbers to push the sport, including first ascents in the Westfjord of Iceland and becoming the first woman in the Americas to climb M11.

A pair of tall socks from Darn Tough are my favorite wool socks, said Glanc of the now 10-year-old Vertex Over-the-Calf Ultra-Light. She wears these socks year-round in the summer as hiking socks and in winter for skiing as well as ice and mixed climbing.

For length, she prefers tall for the functionality and extreme fashion.The socks will not wear out! They have outlasted every other pair of socks I have had, she said.

Shop Now

From hiking boots to snow boots, these are the best men's winter boots of 2020; Including top picks from Sorel, KEEN, Kamik, and more. Read more

We tested and reviewed the best women's winter boots of 2020. Check out winter hiking boots and snow boots from Kamik, Bogs, and more. Read more

Excerpt from:
The Best Wool Socks According to Experts - GearJunkie

Physiology

Reelin reverts main pathological processes related to Alzheimer’s and other tauopathy – Mirage News

Image of a primary neuronal cell culture with detection of MAP2 dendritic marker (red) and Neurofilament axon marker (green).

Promoting the signalling pathway of reelin an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance the main cognitive, biochemical and behavioural alterations seen in Alzheimers and other pathologies associated with Tau protein, as shown in a new study with animal models published in the journal Progress in Neurobiology.

The study proves the determining role of reelin in the modulation of pathological processes associated with Alzheimers and other tauopathies (accumulation of amyloid plaques, aberrant distribution of Tau phosphorylated, synaptic dysfunction and memory loss), and opens a new perspective to design future therapeutical targets and drugs to fight these disorders.

The first author of this study is the researcher Daniela Rossi, and it is led by Eduardo Soriano and Llus Pujadas, members of the Faculty of Biology and the Institute of Neurosciences (UBNeuro) of the University of Barcelona, the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) and the Vall dHebron Research Institute (VHIR).

Other participants are the experts Agns Gruart, Jos M Delgado and Gerardo Contreras-Murillos (University Pablo de Olavide), Jess vila (Center for Molecular Biology Severo Ochoa, CBM), and Ashraf Muhaisen (UB-UBNeuro-CIBERNED-VHIR). This new study on neurosciences counts on the support of the Research Challenges program (Biomedicine) from the Spanish Ministry of Economy and Competitiveness (MINECO) and La Marat de TV3.

Reelin, an essential protein for brain plasticity

Alzheimers disease is a neurodegenerative disease known for the loss of connection between neurons and neuronal death. It is largely linked to the creation of senile plaques (formed by the amyloid-beta peptide, or A), and the presence of neurofibrillary balls (insoluble deposit of Tau).

In the adult brain, the loss of reelin has been related to an increase in the phosphorylation of Tau protein a factor which is related to the microtubules mainly expressed in neurons- which ends up in neurofibrillary ball form typical from Alzheimers.

Therefore, the different states of phosphorylation and dephosphorylation of Tau represent a determining factor in the stability of the cell cytoskeleton and, as a result, of the synaptic and dendritic stability. Hyperphosphorilation and accumulation of Tau causes neuronal death.

In this context, the function of the reelin protein to promote synaptic plasticity and reduce Tau phosphorylation was considered a potential mechanism to reduce the consequences of the neurodegenerative process and protect the brain from neuronal damage.

New beneficial effects of reelin in animal models with tauopahy

In previous studies, experts had affirmed the alteration of reelin in Alzheimers disease and its role in intracellular signalling pathways related to neuronal survival and the physiology of the adult brain. Researchers had described the active role of reelin in the recovery of cognitive functions and the reduction of fibers of the A peptide in vitro and amyloid deposit in the brain in animal models with Alzheimers (Pujadas et al. Nature Communications, 2014).

The published study in Progress in Neurobiology describes new molecular data on the signalling pathway of reelin and reveals how this protein can reverse the main pathological affectations of Alzheimers at different levels in animal models affected by tauopathies. In particular, the results reveal that overexpression of reelin is able to modulate levels of phosphorylation of the Tau protein in in vivo models.

Moreover, the in vitro studies confirm the ability of reelin to modulate the anomalous distribution of neurofilaments and Tau protein in dendrites, which is shown in the first phases of these neuropathologies. Last, regarding the cognitive and physiological fields, overexpression of reelin revealed an improvement of deficits that affected a new animal model of tauopathy.

Article reference:

Rossi, D.; Gruart, A.; Contreras-Murillo, G; Muhaisen, A.; vila, J.; Delgado-Garca, J.; Pujadas, L.; Soriano, E. Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy. Progress in Neurobiology, December, 2019. Doi: https://doi.org/10.1016/j.pneurobio.2019.101743

See the original post here:
Reelin reverts main pathological processes related to Alzheimer's and other tauopathy - Mirage News

Physiology

Mota Ventures Forms Research and Development Partnership with Leading Colombian University & Research Hospital – GuruFocus.com

VANCOUVER, BC / ACCESSWIRE / January 23, 2020 / Mota Ventures Corp. (CSE:MOTA)(FSE:1WZ:GR)(OTC:PEMTF) (the "Company") is pleased to announce that its wholly owned subsidiary Ihuana S.A.S ("Ihuana") has entered into a research cooperation agreement (the "Agreement") with La Fundacion Universitaria de Ciencias de la Salud (The University Foundation of Health Sciences) (the "University") located in Bogota, Colombia. Pursuant to the Agreement, the parties intend to engage in research and formulation of medicinal products made with non-psychoactive cannabis and cannabis byproducts.

The University is a not-for-profit private educational and health care university founded in 1976. Between their two locations, including a Children's Hospital in San Jose, the University has the necessary technology for highly specialized medical and surgical treatments including an automated clinical laboratory, diagnostic imaging, neurological sciences, internal medicine and outpatient care. Additionally, the foundation offers laboratories in biology, biochemistry, anatomy, physiology, genetics, immunology, histology, microbiology and clinical stimulation.

Ihuana and the University will cooperate in the development of scientific investigations related to the medical use of products made with cannabis. The research teams from both groups will work closely to design and execute studies, with the University providing the infrastructure and connections to different researchers and Ihuana supplying various resources, including testing materials. Cost of the research will be negotiated between the two parties for each individual research product and intellectual property from the study will be divided based on capital input from each side.

The University agrees to enable access and interaction with partner hospitals and research centers that will take part in clinical studies and trials and will allow access to institutional resources to finance research through existing relationships.

"This partnership gives us an immediate foothold in the medicinal market in Colombia. We are very fortunate to partner with one of the leading universities in South America. This will allow for rapid development of new products for the domestic and international markets," stated Joel Shacker, CEO of the Company.

About Mota Ventures Corp.

Mota Ventures is seeking to become a vertically integrated global CBD brand. Its plan is to cultivate and extract CBD into high-quality value-added products from its Latin American operations and distribute it both domestically and internationally. Its existing operations in Colombia consist of a 2.5-hectare site that has optimal year-round growing conditions and access to all necessary infrastructure. Mota Ventures a seeking to become a vertically integrated, revenue-producing CBD company with operations in both Europe and North America. Mota is looking to establish sales channels and a distribution network internationally through the acquisition of the Sativida and First Class CBD brands. Low cost production, coupled with international, direct to customer sales channels will provide the foundation for the success of Mota Ventures.

About the University Foundation of Health Sciences

The University Foundation of Health Sciences is a modernized private educational and health care university founded in 1976. Between two locations, including a Children's Hospital in San Jose, the University has the necessary technology for highly specialized medical and surgical treatments including an automated clinical laboratory, diagnostic imaging, neurological sciences, internal medicine and outpatient care. Additionally, the foundation offers laboratories in biology, biochemistry, anatomy, physiology, genetics, immunology, histology, microbiology and clinical stimulation.

ON BEHALF OF THE BOARD OF DIRECTORSMOTA VENTURES CORP.

Joel ShackerChief Executive Officer

For further information, readers are encouraged to contact Joel Shacker, President & CEO at +604.423.4733 or by email at [emailprotected] or http://www.motaventuresco.com

Neither the Canadian Securities Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this press release, which has been prepared by management.

Cautionary Note Regarding Forward-Looking Statement

All statements in this press release, other than statements of historical fact, are "forward-looking information" with respect to the Company within the meaning of applicable securities laws, including with respect to research and development projects with the University, its plans to become a vertically integrated global CBD brand, its plans to cultivate and extract cannabis to produce CBD and high-quality value added CBD products in Latin America for distribution domestically and internationally and its plans to acquire revenue-producing CBD brands and operations in Europe and North America. The Company provides forward-looking statements for the purpose of conveying information about current expectations and plans relating to the future and readers are cautioned that such statements may not be appropriate for other purposes. By its nature, this information is subject to inherent risks and uncertainties that may be general or specific and which give rise to the possibility that expectations, forecasts, predictions, projections or conclusions will not prove to be accurate, that assumptions may not be correct and that objectives, strategic goals and priorities will not be achieved. These risks and uncertainties include but are not limited those identified and reported in the Company's public filings under the Company's SEDAR profile at http://www.sedar.com. Although the Company has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking information, there may be other factors that cause actions, events or results not to be as anticipated, estimated or intended. There can be no assurance that such information will prove to be accurate as actual results and future events could differ materially from those anticipated in such statements. The Company disclaims any intention or obligation to update or revise any forward-looking information, whether as a result of new information, future events or otherwise unless required by law.

SOURCE: Mota Ventures Corp.

View source version on accesswire.com: https://www.accesswire.com/573898/Mota-Ventures-Forms-Research-and-Development-Partnership-with-Leading-Colombian-University-Research-Hospital

Go here to see the original:
Mota Ventures Forms Research and Development Partnership with Leading Colombian University & Research Hospital - GuruFocus.com

Physiology

Reelin can reverse the main pathological processes associated with Alzheimer’s, other tauopathies – News-Medical.net

Promoting the signaling pathway of reelin -an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance the main cognitive, biochemical and behavioral alterations seen in Alzheimer's and other pathologies associated with Tau protein, as shown in a new study with animal models -published in the journal Progress in Neurobiology.

The study proves the determining role of reelin in the modulation of pathological processes associated with Alzheimer's and other tauopathies (accumulation of amyloid plaques, aberrant distribution of Tau phosphorylated, synaptic dysfunction and memory loss), and opens a new perspective to design future therapeutical targets and drugs to fight these disorders.

The first author of this study is the researcher Daniela Rossi, and it is led by Eduardo Soriano and Llus Pujadas, members of the Faculty of Biology and the Institute of Neurosciences (UBNeuro) of the University of Barcelona, the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED) and the Vall d'Hebron Research Institute (VHIR).

Other participants are the experts Agns Gruart, Jos M Delgado and Gerardo Contreras-Murillos (University Pablo de Olavide), Jess vila (Center for Molecular Biology Severo Ochoa, CBM), and Ashraf Muhaisen (UB-UBNeuro-CIBERNED-VHIR). This new study on neurosciences counts on the support of the Research Challenges program (Biomedicine) from the Spanish Ministry of Economy and Competitiveness (MINECO) and La Marat de TV3.

Alzheimer's disease is a neurodegenerative disease known for the loss of connection between neurons and neuronal death. It is largely linked to the creation of senile plaques (formed by the amyloid-beta peptide, or A), and the presence of neurofibrillary balls (insoluble deposit of Tau).

In the adult brain, the loss of reelin has been related to an increase in the phosphorylation of Tau protein -a factor which is related to the microtubules mainly expressed in neurons- which ends up in neurofibrillary ball form -typical from Alzheimer's.

Therefore, the different states of phosphorylation and dephosphorylation of Tau represent a determining factor in the stability of the cell cytoskeleton and, as a result, of the synaptic and dendritic stability. Hyperphosphorilation and accumulation of Tau causes neuronal death.

In this context, the function of the reelin protein to promote synaptic plasticity and reduce Tau phosphorylation was considered a potential mechanism to reduce the consequences of the neurodegenerative process and protect the brain from neuronal damage.

In previous studies, experts had affirmed the alteration of reelin in Alzheimer's disease and its role in intracellular signaling pathways related to neuronal survival and the physiology of the adult brain. Researchers had described the active role of reelin in the recovery of cognitive functions and the reduction of fibers of the A peptide in vitro and amyloid deposit in the brain in animal models with Alzheimer's (Pujadas et al. Nature Communications, 2014).

The published study in Progress in Neurobiology describes new molecular data on the signaling pathway of reelin and reveals how this protein can reverse the main pathological affectations of Alzheimer's at different levels in animal models affected by tauopathies. In particular, the results reveal that overexpression of reelin is able to modulate levels of phosphorylation of the Tau protein in in vivo models.

Moreover, the in vitro studies confirm the ability of reelin to modulate the anomalous distribution of neurofilaments and Tau protein in dendrites, which is shown in the first phases of these neuropathologies. Last, regarding the cognitive and physiological fields, overexpression of reelin revealed an improvement of deficits that affected a new animal model of tauopathy.

Source:

Journal reference:

Rossi, D., et al. (2019) Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy. Progress in Neurobiology. doi.org/10.1016/j.pneurobio.2019.101743.

Continue reading here:
Reelin can reverse the main pathological processes associated with Alzheimer's, other tauopathies - News-Medical.net