Category Archives: Physiology

Medical Students’ Perception of Their Education and Training to | AMEP – Dove Medical Press

Mohamed Abdelrahman Mohamed Iesa

Department of Physiology, Faculty of Medicine, Umm Al-Qura University, Al Qunfudhah, Makkah, Saudi Arabia

Correspondence: Mohamed Abdelrahman Mohamed IesaDepartment of Physiology, Faculty of Medicine, Umm Al-Qura University, P.O. Box: 715, Al Qunfudhah, Makkah, Saudi ArabiaTel +966 538832384Fax +966 177461197Email mohamedovi1@gmail.com

Purpose: Medical studies is a very diverse field of education that seeks to prepare students for a rapidly evolving healthcare market. This study presents the findings of a survey about the perception of medical students about whether they receive training in professionalism and management skills and whether their education prepares them to face the evolving market trends.Methods: This was a qualitative study that used descriptive data obtained via an online survey conducted among medical students via WhatsApp. The sample included 500 students from 10 medical schools across the UK. The survey was divided into three parts: The first part contained questions related to professionalism and the training they received at the basic level. The second part contained questions about management and leadership training for the medical field and whether the students thought it was important for their future. The last part contained questions about whether the students thought that their level of education was competitive enough to ensure their survival in the face of future market trends.Results: Most students (77%) thought that training in leadership and management skills was necessary to prepare them for the future market, and 68% felt that they were not receiving satisfactory training in leadership and management skills. The students also felt that they need to be taught more about the market and its various changing features. Finally, the majority (62%) of the students felt that their courses did not focus on social and professional skills.Conclusion: The findings from the survey indicate that there is a clear need for courses on professionalism and management among medical students and that institutes need to keep up with these emerging needs in terms of training.

Keywords: professionalism, management skills, qualitative study, team work, elements of professionalism

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Medical Students' Perception of Their Education and Training to | AMEP - Dove Medical Press

How to live well with stress even in the coronavirus era – University of California

Understanding the science of stress has never seemed more important for our health. It doesn't just make your palms sweaty, after all: it causes health problems and can even age you! Learn how to cope with tips from UCSF psychologist Elissa Epel.

Bills, family, health worries, jobs Americans are some of the most stressed out people in the world.

And that was before coronavirus.

A 2019 Gallup poll of more than 150,000 people around the world found that 55 percent of American adults said they spent much of their past day stressed, 20 points higher than the global average. If continued for months and years, thats a level of stress experts like UC San Francisco psychologist Elissa Epel call chronic stress, which is linked to elevated risks for health problems from heart disease to depression. And if thats not enough, chronic stress can actually, physically age you, according to studies by Epels lab.

But take a deep breath. Its not all bad news.

We tend to think that stress is a bad thing, but actually it really matters what type of stress we're under, and how we respond to it, she says.

Some stress, according to Epel, is actually good for you.

Epel and her lab study stressors and our reactions to them and how we react to stressors is more important than you might guess. Stressors can be acute or chronic.

Chronic stressors are things that are ongoing like financial strain, caretaking duties for a sick family member or a demanding job the things that never seem to go away and deplete us.

An acute stressor might be a presentation you have to make in class, or trying something new youve been afraid to do. Theyre a little bit like growing pains your heart might pound, your palms might get sweaty, but it will soon be over and once it is, you might even feel great. And not just because you took on a challenge and succeeded your cells are reacting to this short-term stress in a very healthy way.

When worms or mice are exposed to short bursts of stress, they actually become healthier and can live longer, Epel says. Thats because of a phenomenon known as hormesis when our bodies mount a stress response, they also mount a counterregulatory stress response to help us recover.

Call it a challenge response to stress. The small dose of stress prompts an adaptation to stress, which leaves our cells younger. A process like Pac-Men in our cells starts cleaning up junk what scientists call autophagy. The physical stress of exercise, heat and intermittent fasting may cause autophagy to increase. The science of autophagy is still emerging, but so far it seems like it can help protect us from diseases from Parkinsons to Huntingtons, or even dementia.

Discoveries in the field won Japanese cell biologist Yoshinori Ohsumi the 2016 Nobel Prize in physiology or medicine.

But if your psychological reaction to chronic or even acute stress is a threat response meaning you perceive a minor threat as a true threat to your ego or survival you might not get the same beneficial recovery process. You may have a very slow physiological recovery from the stressor, and less clean up activity in the cell. You may even be unconsciously carrying this level of high alert around with you. Its like a novice playing Pac-Man on the highest difficulty level. The ghosts win, and yet you have to keep playing. Thats your cells wearing out.

To get a clearer picture of how stress acts at a cellular level, Epel and her collaborators teamed up with UC San Franciscos Elizabeth Blackburn, a Nobel Prize winner in her own right. Blackburn is a pioneer in studying cell aging. She studies telomeres, the caps on the end of our chromosomes, and telomerase, the enzyme that protects them from things like oxidative stress.

Our telomeres grow shorter as we age. Studies have shown that when people have genes for lower telomerase, they have more rapidly shortening telomeres and tend to get earlier onset of diseases of aging, like Alzheimers and dementia.

So Epel wanted to ask a very simple question do people under chronic stress have shorter telomeres?

They measured the telomeres of people who report high levels of chronic stress caregivers of children with serious ongoing medical conditions and found a direct correlation between the number of years spent caring for their child and decreased telomere length. Having shorter telomeres means the cells will reach replicative senescence sooner, in that they will lose the ability to keep dividing into new cells, and will instead stick around wreaking havoc creating inflammation in the blood. Chronic stress causes at least this one type of biological aging.

But when they took a closer look at the data, they found that shorter telomeres werent caused by the situation of caregiving but how stressed the caregiver felt.

It wasn't being a caregiver per se that predicted ones telomere length, but whether someone felt overly stressed by life. So the caregivers who have felt particularly high levels of stress from their life had significantly shorter telomeres, Epel says.

Fortunately, scientists like Epel have learned many things about stress resilience by studying people in caregiving roles.

For women who reported higher levels of stress related to their role as parents, those who saw their role as giving their life meaning and purpose had the best biological health. The term researchers use for it is eudaimonic well-being, a term defined by UCSF assistant professor and psychologist Alexandra Crosswell as a sense of inner wellness that comes from self-realization and feeling that one's life has meaning and purpose.

Greater sexual intimacy with their partner was associated with better metabolic health and longer telomeres, too.

So how do we increase our resilience to stress, and improve our emotional health?

Creating buffers between us and our stress is one of the most important things we can do. One way is through daily habits that reduce physiological stress. An antioxidant diet (whole foods, fruits and veggies) is powerful. Deep, restful sleep is, too. Both have been linked to longer telomeres. And meditation or other mind body practices are important creating restorative time for your body and mind to recover.

When we become aware of how we are thinking during stress, and see these as just thoughts rather than reflecting some ultimate reality, we can actually take away the power these thoughts have over our body, Epel says.

Conditioning our bodies to realize that a lot of the things we get stressed about arent life-threatening can be really helpful.

Triggering our challenge response with some types of brief acute stress can also help keep us healthy. Exercise is one of the most important things we can do in terms of chronic stress, Epel says. The Wim Hof breathing method, which involves meditation with a specific breathing sequence, is currently being studied by Epel and her colleague Wendy Mendes to see if it might induce cellular health and rejuvenation, too.

Other acute stressors commonly found in traditional cultures are also getting a closer look, including fasting and hot/cold exposure. UCSF assistant professor Ashley Mason, for example, is studying the use of sauna for relieving depression. Again, acute stress isnt always good, because too much of it can lead to chronic stress. But paired with a positive mental challenge response, it may bolster our energy and health.

And what about the new stressor that has just landed in America the coronavirus?

It is natural and effective to have anxiety in the context of a pandemic, Epel says. But we can use stress science to help us distinguish a useful stress response from an exaggerated one. Our anxiety about coronavirus drives us to perform safety behaviors like physical distancing. It's a miserable situation for many, but it does show how the natural stress response of fear motivates us to stay safe from natural threats. On the other hand, when we catastrophize about the level of risk, perceiving it as the apocalypse, we dont think clearly and may engage in excessive panic buying, along with making others feel panicky, too.

Alexandra Crosswell has some tips on how to make the best of coronavirus anxiety.

Research suggests that stressors can be good because they help us refine our values, focus on what's important in our lives, make needed changes (e.g. start exercising, cooking healthy meals, get more sleep), and help us connect meaningfully with our loved ones, she says.

She suggests using this current moment to take stock of your life and make changes that promote a feeling of well-being even if you're worried about the virus or the rapidly evolving situation. To the extent coronavirus is experienced as an acute stressor, and we dont let it turn into panic, there are opportunities to be healthier.

Even having to work harder to make time for friends or to fill our time could actually be ... good for us.

Yes, its possible! Trying new things is good for us! Crosswell says. One of the keys to maintaining cognitive health as we age is novelty. One of my neighbors said her mother, who is in a nursing home and thus is isolated from visitors, is thriving because they got a new care staff and now she is in charge of showing the new staff how things work (e.g. this is how you wrap my leg, this is how we determine who sits where at dinner), and she loves the ability to finally feel like she's contributing and in control. Being open to the changes that this situation will force on us may be one of the best ways to cope with this uncertainty.

So while you might not like having to stay inside, think of it as a chance to pick up the guitar, take an online class in something new, or try a novel way of helping and connecting with others. There are studies that show that acute stressors (especially when perceived as challenges) directly lead to more creativity, too.

Of course, coronavirus is not just an acute stressor, and for some in the U.S. who are at very high risk it may already be overwhelming, or exacerbating existing chronic stressors. While meditation cant fix the coronavirus or job loss, it can help mitigate the impact of the negative emotions that come with those pressures.

In a piece for the San Francisco Chronicle, Epel addressed some of the other ways we can cope with how coronavirus might affect us.

Humans are built for enduring long periods of adversity, Epel says. We get over stressful periods. As long as we dont have a prolonged and exaggerated emotional response, we recover really well. Getting too absorbed in images of disasters on the media for too much of the day predicts longer term mental and physical health problems. Try to take only small doses of media, and many restorative breaks during the day.

One of the most powerful ingredients for stress reduction is warm, caring emotional support. Helping behaviors are known to be happiness behaviors, as well.

She suggests we first acknowledge the situation, and that we cannot control it but that we can control our behaviors to lessen the chance of contagion and flatten the curve, as they say. This has already been helpful in places like China, she points out, and it can work for us, too. Label your thoughts and emotions, so you can switch from an emotional mode to a kind and reflective observer mode: So this is what it feels like to live in a pandemic. It will help the emotion pass more quickly.

Epel also suggests we embrace the opportunity to be extra kind to ourselves and to others, acknowledging that anxiety is inevitable and commonly shared.

One of the most powerful ingredients for stress reduction is warm, caring emotional support, she writes. Opportunities to help abound. Helping behaviors are known to be happiness behaviors as well.

We can check on elderly neighbors, friends and relatives who cannot leave home easily (especially if they are sick), with caring calls or texts, and offers to bring food and medications. Communities are rapidly building their own support networks, using networks such as Nextdoor or Facebook. This is a time we discover who we are as a nation, an opportunity to strengthen our worn-down social cohesion and live our core values.

Whether it be the minor stressors of the everyday concerns, or the real threat of coronavirus, its important to nourish your well-being as a buffer and build your resilience. Learning to cope with stress has never been more important for your health.

Get more coping tips from Elissa Epel and UCSF's stress researchers here.

The research highlighted in this article was supported in part by the National Institutes of Health (National Institute of Aging, The National Heart, Lung, and Blood Institute, The National Center for Complementary and Integrative Health).

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How to live well with stress even in the coronavirus era - University of California

Even After Being a Continuous Process of Plantation and Manufacturing Tea Industry Not Exempted from Lockdown – Guwahati Plus

GUWAHATI: In the 21-day lockdown ordered by PM Narendra Modi to combat COVID-19, the ministry of home affairs has exempted a few services and businesses.

As per point number 5 of the order no. 40-3/2020 dated 24th March of the ministry, industrial establishments are to remain closed. The exceptions to this closure are:

a. Manufacturing units of essential commodities.b. Production units, which require continuous process, after obtaining required permission from the state government.

Despite this order, the tea industry of Assam has not been exempted from the lockdown.Given the fragile and perishable nature of the tea plants, the Assam Valley Branch of Consultative Committee of Plantation Associations had requested the Labour Commisssioner to exempt specific operations of the industry.

The application requested that tea gardens be allowed to work for the protection of the plants by spraying of pest repellents and pest killers as there might be huge and permanent damage to the plants during such a long closure period.

Further, irrigation of plants to be continued, given scanty rainfall during the period.

Dipanjol Deka, Secretary of Tea Association of India, speaking to G Plus informed, The Deputy Commissioner of some districts have allowed us to keep five workers per day per garden for the required work. However, all district authorities have not yet complied to our request.

Given that the tea plantation and manufacturing business is a continuous process, the state government should have exempted us from the lockdown, he added.

Nazrana Ahmed, President of Assam Tea Planters Association said, The tea industry was already in a crisis in the last two years, and from the beginning of this year there has been a drop of sale prices in the Gauhati Tea Auction by an average of Rs. 80 to Rs. 90 per kg.

Further, the tea industry is dealing with a very fragile and perishable commodity dependent on plant physiology and are infected by pests. The plucking is done on a round of every six to seven days. So during lock down these plants would grow about a foot long and has to be skiffed as these cannot be used for the manufacture of tea. We have to wait for regeneration of the bushes again. So a lock down of five days actually means about a month long lock down for the tea industry

As such given the three-week long lockdown the losses to be incurred by the industry could be highly extensive.

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Even After Being a Continuous Process of Plantation and Manufacturing Tea Industry Not Exempted from Lockdown - Guwahati Plus

Want To Get Away? These Astronauts Talk About Life Off Earth, Dealing With Isolation and Facing Fears – WMFE

Scott Kelly on the International Space Station. Photo: NASA

Since our podcast and radio show Are We There Yet? is celebrating its 4th birthday and many of us are quarantined at home with lots of free time our host Brendan Byrne is sharing his favorite conversations with astronauts.

Listen back to his picks on this binge-able list and be sure to subscribe to the podcast, or listen in every Tuesday at 6:30 p.m. ET on WMFE and WMFV.

Scott Kelly spent almost a year in space as part of an experiment to understand how our bodies function for an extending time in microgravity. He spoke to Byrne about the physiological challenges of life off Earth and the emotion toll isolation took on his mind. Kelly recently wrote an op-ed in the New York Times about his time in isolation and his tips for folks during the coronavirus pandemic.

LISTEN: WMFE | Apple Podcasts | Spotify

Canadian astronaut Chris Hadfield most famously spent his time isolated on the International Space Station filming a music video set to David Bowies Space Oddity. But Hadfields trip wasnt all fun and games there was real danger. He spoke with Byrne about how he deals with fear and the unknown.

LISTEN: WMFE

Nicole Stott is a frequent flier on the podcast. On her first appearance on the show, she talks about the hobby she brought up with her for her long stay on the ISS a set of watercolor paints. She tells Byrne about how her time in space gave her a fresh perspective on life down on Earth.

LISTEN: WMFE | Apple Podcasts | Spotify

Space stinks. Well, it doesnt stink until you come back. NASA astronaut Bruce Melnick talks about the wall of smell that hits you when you return to Earth on the Space Shuttle. Melnick also tells Byrne about the challenges of using the space toilet. Really high-brow stuff, we promise.

LISTEN: WMFE | Apple Podcasts | Spotify

Before making history as part of the first all-female spacewalk, Jessica Meir joined the podcast to talk about her expertise the physiology of animals in extreme environments and how the lessons learned will help get humans back to the moon and on to Mars.

LISTEN: WMFE | Apple Podcasts | Spotify

Do you have a favorite episode? Share it with Brendan Byrne and the rest of the space fans out there shoot us an email at AreWeThereYet@wmfe.org

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Want To Get Away? These Astronauts Talk About Life Off Earth, Dealing With Isolation and Facing Fears - WMFE

Fertility wearable to double as COVID-19 temp monitor, as need for population data intensifies – BioWorld Online

Gleaning reliable population-level temperature data routinely has been a key component of the more successful efforts in several Asian countries for containing the emerging, novel coronavirus. But these often have required highly time and labor-intensive coordinated efforts to screen people manually as they access various services such as public transportation and grocery stores.

Remotely monitoring people for the early signs of COVID-19, as well as determining disease progression for infected patients virtually, would offer huge potential advances in better protecting the populace, as well as lessening the burden on swamped health care providers.

Into the gap

Zurich-based startup Ava Science Inc. hopes to step into that gap. The company recently issued a public call for partners and funding to further research the potential usefulness of its fertility wearable, known as Ava Bracelet, during the COVID-19 pandemic.

The effort is not unprecedented; the primary COVID-19 treatment center in Shanghai, the Shanghai Public Health Clinical Center, has been using continuous temperature monitoring in hospitalized patients using wearable technology from Campbell, Calif.-based startup Vivalnk Ltd., which also has a China office. This freed health care staff from routine temperature checks.

Given the current pandemic, we have looked as a company at how we could repurpose our device to help combat the spread of COVID-19, Ava Chief Medical Officer and head of clinical development Maureen Cronin told BioWorld. Cronin was previously the Head of Womens Medical Affairs at Bayer Schering Pharma.

The Ava Bracelet provides the highly accurate temperature readings necessary for this application, as well as other vital sign monitoring. It is already in widespread use throughout the U.S. and Europe and has aided more than 30,000 women in getting pregnant. Ava, which has a U.S. headquarters in San Francisco, is starting to coordinate with various governments, nonprofits, academics and companies to explore the application of its Ava Bracelet for systematic COVID-19 monitoring.

We believe our device, the Ava Bracelet, could be used to detect early symptoms known to be associated with COVID-19 and are seeking funding to test our hypothesis directly, said Cronin. We know that our medical-grade device, worn nightly while the user sleeps, can pick up subtle changes in breathing rate, heart rate, and temperature; the user syncs the device each morning with a smartphone app that shows them how their physiological parameters have changed over the last days, weeks and months.

The nightly log of changes in biophysical data could provide critical insights for first responders and/or people with known or suspected exposure quarantining at home, indicating when they may want to seek medical advice, she continued. Additionally, this data could be shared with health care professionals at time of triaging to demonstrate the trajectory and/or severity of the disease. We believe the Ava bracelet could even serve as a remote surveillance tool in hospital wards, reducing the need for health care professionals to take in-person vitals and thereby minimizing the risk of additional transmission.

In Europe, the device has a CE mark to measure the physiological parameters to facilitate conception and to provide general health and wellness information. In the U.S., where it launched in 2016, FDA approved it as a low-risk class I device for use in conception and physiological changes in subsequent pregnancies. Ava aims to submit to European regulators later this year for a contraception indication.

Remote monitoring priorities

The Ava Bracelet is a wrist worn device that is worn nightly to track breathing rate, pulse rate, skin temperature, heart rate variability, perfusion as well as sleep quality and quantity. Its initial fertility aim was to replace the common fertility practice of monitoring basal body temperature every morning prior to leaving bed to predict when ovulation is most likely to occur.

The most common COVID-19 symptoms are fever, dry cough and shortness of breath, according to the World Health Organization. These occur at a rate of 88%, 68% and 19%, respectively. Ava anticipates that it can detect a fever with both its body temperature and pulse rate monitors, which should both increase, while shortness of breath can be measured as an increased breathing rate. There is obviously no physiological reason why the wearable couldnt be used across genders.

The Ava Bracelet data is analyzed via machine learning to predict a five-day fertile window with 89% accuracy. Its been evaluated in several clinical trials and peer-reviewed manuscripts. The company said that it is currently evaluating data from its users for COVID-19 related trends, but declined to disclose anything further.

The FDA is prioritizing the expansion of the availability and capability of noninvasive remote monitoring devices to facilitate patient monitoring while reducing patient and health care provider contact and exposure to COVID-19 during this pandemic. It released guidance late last week that is designed to enable the smooth repurposing of existing devices and remove potential penalties for repurposing of these devices.

FDA does not intend to object to limited modifications to the indications, claims, functionality, or hardware or software of FDA-cleared non-invasive remote monitoring devices that are used to support patient monitoring during the declared public health emergency, the FDA stated in the new guidance.

Ava declined to name any specific potential partners in its COVID-19 efforts, but did say that it has the capacity to make 50,000 bracelets available shortly with the capacity to further ramp up production. The company has started offering a non-fertility version of the Ava Bracelet for $100 off the standard $249 price to individuals, researchers and medical professionals for physiology tracking.

We have had numerous requests for information and several requests for discussions, said Cronin. The requests have come from current users, potential users, governmental and non-governmental organizations, academics and industries. We are investigating several options as we speak.

We are working towards submitting a grant application for a public-private (academic and industry) grant proposal in Europe by the end of this week, she added. We are a very small organization, but we understand the need to act fast. We are investigating several other proposals in different regions throughout the world and remain open to other proposals.

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Fertility wearable to double as COVID-19 temp monitor, as need for population data intensifies - BioWorld Online

They Dont Hide From the Coronavirus, They Confront It – The New York Times

As the world writhes in the grip of Covid-19, the epidemic has revealed something majestic and inspiring: millions of health care workers running to where they are needed, on duty, sometimes risking their own lives. I have never before seen such an extensive, voluntary outpouring of medical help at such a global scale.

Intensive care doctors in Seattle connect with intensive care doctors in Wuhan to gather specific intelligence on what the Chinese have learned: details of diagnostic strategies, the physiology of the disease, approaches to managing lung failure, and more. The three-page, single spaced document, full of lessons, circulates immediately and widely through social media platforms, a gem borne of pure, professional commitment. Facebook starts a COVID-19 USA Physician/APP Group on March 13. It has 57,000 members on March 15, and 105,000 on March 18.

The Journal of the American Medical Association, even while moving its staff home for social distancing, sets new records for speeding helpful scientific studies, peer reviewed, onto the web. Knowledge grows. One JAMA paper is by a group of Wuhan physicians reviewing patterns and outcomes for 1099 patients, showing surprisingly high rates of severe illness in younger adults. Another is an honest account by physicians in Lombardy of both successes and mistakes as they grapple with unprecedented intensive care demands. A list-serve for hospitals started by the Institute for Healthcare Improvement overflows with questions What have you learned about setting up drive-by testing? Has anyone found a new source of masks? and instant answers from institutions and clinicians.

One anesthesiologist in Valhalla, N.Y., types in a suggestion: Instead of giving up when the ventilators are all in use, how about asking groups of students or family members who have become immune to the virus to ventilate patients manually, using Ambu bags, in shifts even for days at a time? Clinicians reply, some critical, some supportive, and all trying to find answers.

And city by city, hospitals mobilize creatively to get ready for the possible deluge: bring in retired staff members, train nurses and doctors in real time, share data on supplies around the region, set up special isolation units and scale up capacity by a factor of 100 or 1000. On Tuesday, Mayor Bill de Blasio of New York asks for retired medical personnel to join the citys Medical Reserve Corps; 24 hours later, 1000 new volunteers have signed up. Northwell Health, a 23-hospital system in New York City, figures out how to add 1,500 beds, if needed, by repurposing space.

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They Dont Hide From the Coronavirus, They Confront It - The New York Times

Avectas and Vycellix Announce Collaboration to Advance Next-Generation Solutions for the Optimized Manufacture of Cell & Gene Therapies – P&T…

DUBLIN and TAMPA, Florida, March 24, 2020 /PRNewswire/ -- Avectas, a cell engineering technology business and Vycellix, Inc. an immuno-discovery cell & gene therapy company, today announced that the companies have entered into a collaboration agreement to develop proprietary approaches for cell-based immunotherapeutic products.

The companies will collaborate on the delivery of Vycellix's novel RNA immunomodulator VY-M using Avectas' cell engineering platform, Solupore. The collaboration will address current limitations for cell-based therapies, in particular with respect to the need to accelerate the manufacturing process, reduce the cost of manufacture, and ultimately improve patient outcomes.

"We are delighted to partner with Vycellix and join forces in the development of novel cell-based products," says Michael Maguire, PhD, CEO of Avectas. "We believe Solupore will play a critical role in the manufacture of cell-based therapies and will support a path towards effective patient outcomes."

According to Vycellix's President, Douglas Calder, "Solupore represents a new paradigm for delivery of transgenes, and our initial studies will evaluate Solupore to deliver our new product candidate, VY-M, to T cells and NK cells. We expect to accelerate the expansion-time of T cells and NK cells by decreasing the non-dividing lag time, resulting in much shorter "vein-to-vein" delivery-time to patients." The studies will be conducted at Avectas' Dublin-based facility and at Karolinska Institutet, Stockholm, Sweden.

Both Avectas and Vycellix are collaborative partners within NextGenNK, a newly established competence center for development of next-generation NK cell-based cancer immunotherapies based at Karolinska Institutet, Stockholm, Sweden. It is envisioned that Avectas and Vycellix will further expand their collaboration within the NextGenNK constellation.

"We are excited to see the NextGenNK competence center catalysing interactions among its industrial partners to advance NK cell-based immunotherapies," says Hans-Gustaf Ljunggren, MD PhD, Director of the NextGenNK competence center. "The present collaboration may pave the way for similar collaborations among NextGenNK partners."

In February 2020, Avectas announced that it had entered an agreement with the Centre for Commercialization of Regenerative Medicine (CCRM) based in Toronto, Canada to accelerate the translation of Avectas' non-viral cell engineering platform (Solupore) into the clinic.

About Avectas:Avectas is a cell engineering technology business developing a unique delivery platform to enable the ex-vivo manufacture of our partners' gene-modified cell therapy products, which will retain high in-vivo functionality. Our vision is to be a leading non-viral cell engineering technology provider, integrated into manufacturing processes for multiple autologous and allogeneic therapies, commercialized through development and license agreements. For more information, please visit the Company's website at http://www.avectas.com

About Vycellix:Vycellix, Inc.is a private, immuno-discovery, life science company at the forefront of innovation in the development of cell & gene-based therapies targeting indications in, but not limited to, hematology/oncology, autoimmunity/chronic inflammatory diseases, and organ/tissue transplantation.

The Company's platforms were all initially discovered by scientists at the world-renowned Karolinska Institutet (KI) in Stockholm, Sweden. KI is globally recognized for its Nobel Assembly, which awards the Nobel Prize in Physiology or Medicine. For more information, please visit the Company's website at http://www.vycellix.com

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Avectas and Vycellix Announce Collaboration to Advance Next-Generation Solutions for the Optimized Manufacture of Cell & Gene Therapies - P&T...

The Beatless Beat Writer: The Physiology of the Crimson Tide – Sports Illustrated

Its so quiet.

That was the thought that filled my head as I drove around campus on Friday morning. As emails from the University of Alabama fill students inboxes pleading them not to return from spring break, the campus remains free of the chatter of students and the life that they bring with them.

If students are the crimson blood that brings life into the campus, then Alabama athletics are the lungs that provide that same blood with oxygen and therefore, life.

With both the blood and the lungs currently incapacitated, campus is dead.

I dont mean that in a doomsday, apocalyptic sense. Only temporarily. With all spring sports cancelled, however, there is still one hope that can bring the University of Alabama back from the dead.

Alabama athletics can breathe new life into campus once again.

Now, while I am sitting here on the topic of comparing the human body to the UA campus, it is by pure perfect coincidence that I stumble across this tweet from Big Al on social media:

Listen to the crowd. The eruption. The life. But there is one important sound that happens in the very beginning of the video, as the pulsating crimson LEDs inject atmosphere into Bryant-Denny Stadium.

Did you hear it?

Listen carefully.

Can you hear it now?

That is the sound of a heartbeat.

Alabama athletics and its student-athletes are the lungs of campus, students are the blood, and the stadiums are the heart. They circulate the newly-oxygenated and rejuvenated students throughout their daily lives. They motivate them. Empower them.

This applies not only to the students, though. While the students are the rowdiest section of the stadium, the overall Crimson Tide fanbase is reinvigorated by the stadiums on the campus of UA.

Now, I am not just referring to Bryant-Denny Stadium. I am referring to all of them. Coleman Coliseum. Rhoads Stadium. Sewell-Thomas Stadium. Alabama Soccer Stadium. Alabama Aquatic Center. Roberta Alison Baumgardner Tennis Facility.

These hearts beat to the rhythm of its fanbase when filled with blood. So many historic moments and iconic players have entered and performed for its fans on their fields, courts and in their pools.

This is no one-way street, though. While Alabama athletics and their stadiums provide the metaphorical oxygen to invigorate its students and fans, those same students and fans provide the life in the heart and the lungs.

While the campus might remain quiet for the foreseeable future, the hope that Alabama athletics will once again breathe new life into campus is far from gone.

While we all might miss them now, we all know deep down that we will see them again.

A body cannot last long without its heart and lungs, but trust me when I say that before we know it, the Crimson Tide will bring us joy once again.

The Beatless Beat Writer is a series of stories by BamaCentral's own Joey Blackwell. The series is meant to reflect and discuss Alabama athletics and its fans in Tuscaloosa during the current pandemic.

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The Beatless Beat Writer: The Physiology of the Crimson Tide - Sports Illustrated

COVID-19: Fitness experts offer advice for fighting off the Quarantine 15 – The Sudbury Star

Deanna Harder, a CSEP (Canadian Society for Exercise Physiology) certified personal trainer in Edmonton poses for a picture at Custom Fit Training in Edmonton on March 18, 2020. Derek Van Diest / Postmedia

It is being called the Quarantine 15 in social media circles: the weight some are expecting to gain during the COVID-19 pandemic.

With gyms and leisure centres throughout Edmonton closed, there is concern self-isolation will be detrimental to an active lifestyle.

According to some fitness experts, however, that doesnt have to be the case, with numerous types of home workouts available.

I want to let everybody know that your body isnt made or broken in a few weeks or a few months, said Deanna Harder, a CSEP (Canadian Society for Exercise Physiology) certified personal trainer in the city. So just like building muscle takes years and years and years, atrophy in muscle is going to take a little bit of time. Its not going to happen overnight.

You can maintain your body fitness by body-weight exercise or light dumbbell work and just by keeping your stress low and managing your nutrition. You dont need to be going hard every day. I like to tell people, youre not going to make or break your body in a few weeks of not hitting the gym hard. In fact, your body may welcome the change of pace and the change of stimulus. Your gains are not going to be lost in a couple of weeks of staying home.

Harder understands these are stressful times for everyone with the uncertainty ahead due to the world-wide pandemic. Physical activity helps alleviate stress at the best of times and when it is taken away in the form of facility closures, it may only add to anxiety.

The thing is, the first couple days, you might want to eat a little bit of extra chocolate and sugar because youre stressed out and because its like a snow day, Harder said. You can treat it as a little bit of a holiday, a little bit of a staycation, but then weve got to get some structure in our day, like having a healthy breakfast and getting into a regular routine; your showering routine, put on your makeup, put on your clothes, make yourself feel better, your self-esteem will really appreciate that.

And then add in a structured workout starting as soon as you feel good again. There might be a few days where, like my myself, Ive stocked up on a few bottles of wine and some dark chocolate because I also know that comfort is something we all need right now and this isnt going to last forever. If we cant be out in the in the world working on our fitness at a big global gym, why not take this time to focus on nutrition and focus on eating healthier.

Jeff Woods, owner of Custom Fit Training in Edmonton poses for a photo on March 18, 2020. Derek Van Diest / Postmedia

A key issue with self-isolation at home is the access to food at all times. Maintaining a healthy diet is key to fighting off the Quarantine 15. It is fine to stock up on chips and frozen pizza, but as is the case under regular circumstances, moderation is important when trying to maintain a healthy lifestyle.

Whether youre exercising or not, if youre being rational about your intake of calories, youre not going to put on copious amounts of weight, said Jeff Woods, owner of Custom Fit Training. Obviously, we still want people to exercise and you can do that going outside not being in highly populated situations. Be one with nature; that still works.

You can do bodyweight training programs, you can look at virtual options, go online, theres a million options on YouTube. I hate to sort of pass the buck, and as a professional trainer we can certainly pass on good information to people online as well, but there are some really incredible home programs that you can you can pick up the internet, and itll work just fine.

Custom Fit is a small gym catering to clients interested in one-one-one personal training. They, too, will be hit hard financially as the province attempts to get through the outbreak by practicing social distancing.

If there are any positives to be taken out of self-isolation, it may be an opportunity to change a fitness routine. Gains are often difficult to make if a routine becomes too repetitive.

Elite-level athletes work on what we call a periodization model, Woods said. Theyll work for a period of time like a six-week training block and then theyll take structured time off. They might take a week off, so that they give their body a chance to recover and actually adapt to the exercise stress, so that they get stronger.

If you keep on working out all the time and there is no structured recovery time or rest period, you can actually go the other way. If you overtrain, you can actually impede or inhibit your immune systems function. You need to exercise but in times like this, too, you want to do it in a balanced manner, because over-exercising or overtraining can have a negative effect on immunity.

No one is certain how long the self-isolation period will last, but the goal for most is to come out of it in similar condition as they went into it.

People shouldnt worry so much about body change right now, Id worry about more about maintaining your body, just maintain where youre at, Harder said. Dont worry about cutting or gaining at this point because why add extra stress to yourself? Just moderation of all foods, try to focus on maintaining your fitness and your body weight and not worry so much about losing or gaining, just living in maintenance for a minute.

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COVID-19: Fitness experts offer advice for fighting off the Quarantine 15 - The Sudbury Star

Identify the root of your symptoms using functional blood tests at RedRiver Health and Wellness – St George News

Stock image, St. George News

CONTRIBUTED CONTENT Have you seen your doctor because you suffer from fatigue, brain fog, hair loss, digestive issues, joint pain, or other symptoms, and you were told your blood test is normal? You may have even been given a prescription for antidepressants, because your tests dont seem to indicate you have a physical health problem.

You know something is wrong and that youre not supposed to feel this way, but what is the cause? At RedRiver Health and Wellness Center, we believe the reason your blood test didnt show anything wrong with you is because most doctors use lab ranges instead of functional ranges when evaluating the results.

A lab range identifies acute disorders and diseases, while a functional range uses parameters of optimal health and identifies problems that often can still be reversed. This allows you to do something about the problem before its too late.

For instance, using a functional range, you can identify hypothyroidism even though your primary thyroid marker is normal according to a lab range.

Address your health problem before its too late

In functional medicine, we identify and manage the root cause of symptoms instead of using drugs or surgery to stamp them out although medications or surgery may still be necessary in some cases. The most common analogy we use in functional medicine is that when the check engine light comes on, we look under the hood to diagnose the problem instead of turning off the engine light.

Functional blood test ranges, which outline the parameters of good health, are an important tool to help us with this.

What is the difference between functional ranges and lab ranges on a blood test?

For the most part, lab ranges are based on a bell-curve analysis of the people who had blood drawn at that lab over a certain period of time. Naturally, many of these people are getting their blood drawn because they have a health problem.As a result, lab ranges have broadened over the last 20-30 years as the health of the United States population has declined.

This means many people with health issues may be told nothing is wrong because their labs fit in with most people at that lab. If you want to evaluate your health in terms of what is optimal, then functional ranges are the way to go.

Looking for patterns on a functional blood test

With a functional blood test, we also look at patterns of markers instead of looking at each marker in isolation. This is based on understanding that various aspects of human physiology are interrelated and affect one another. Doing this allows us to see how different systems influence one another to cause a pattern of symptoms.

For instance, evaluating immune cells more broadly can give us clues as to whether inflammation is chronic or acute and whether it is caused by a virus, bacteria, allergies or parasites. Other patterns can help us spot fatty liver, leaky gut, different types of anemia or autoimmune disorders. This then helps us determine what types of testing are further needed.

Functional blood tests are more thorough

Functional medicine blood tests are also more comprehensive than a standard blood test.For example, a basic thyroid test from your doctor probably only looks at TSH, or thyroidstimulating hormone. However, because autoimmune Hashimotos, which attacks and destroys the thyroid gland, causes 90% of hypothyroid cases in the United States, we run autoimmunemarkers to screen for Hashimotos. We also look at other markers to see whether additional factors are contributing to your low thyroid symptoms.

Ask my office for more information regarding a functional blood test if you are struggling withchronic health symptoms that are sabotaging your quality of life.

Written by JOSH REDD, chiropractic physician atRedRiver Health and Wellness Center.

S P O N S O R E D C O N T E N T

About Dr. Josh Redd

Josh Redd, MS, DABFM, DAAIM, is a chiropractic physician and author of the Amazon bestselling book The Truth About Low Thyroid. Redd owns seven functional medicine clinics in the western United States and sees patients from across the country and around the world who are suffering from challenging autoimmune, endocrine and neurological disorders. He also teaches thousands of health care practitioners about functional medicine and immunology, thyroid health, neurology, lab testing and more.

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Identify the root of your symptoms using functional blood tests at RedRiver Health and Wellness - St George News