Category Archives: Organic Chemistry

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Prof. Dibakar Chandra Deka assumes the charge as Vice Chancellor of Mizoram University

30/2023-2024

Aizawl, the 1st May 2023: Prof. Dibakar Chandra Deka officially joined his office as the new Vice Chancellor of Mizoram University on 1st May, 2023. The charge was handed over by the acting Vice Chancellor Prof. Pravakar Rath at the Vice Chancellors office chamber.

To mark the occasion, a welcome programme was organized at MZU Auditorium. The programme was presided by the Finance Officer and Registrar in-charge, Prof. Vanlalchhawna who gave a brief bio-data of the new vice chancellor.

The outgoing acting Vice Chancellor Prof. Pravakar Rath welcomed the new vice chancellor on behalf of all the staff and faculty of Mizoram University. He remarked that his 5 and a half months as Vice Chancellor of Mizoram University was one of the best learning experiences he has had and hope that Prof. Dekas 5 year tenure will bring a change in the right direction.

Prof. Dibakar Chandra Deka, the fifth Vice Chancellor of Mizoram University in his address thanked all the MZU teaching and non-teaching staff for the welcome. He conveyed that with cooperation and the drive to always look forward and develop, the university will surely reach new heights. He also mentioned that the first short term plan for Mizoram University is to achieve A++ grade in the upcoming NAAC assessment. Mizoram University despite its young age is one of the fastest developing universities in the country and the skys the only limit, he added.

The programme concluded with a self introduction from the participants including deans, head of departments, teaching and non-teaching staff and students council representatives.

PROF. DIBAKAR CHANDRA DEKA

Prof. Dibakar Chandra Deka attained his B.Sc (Hons) Degree from Cotton College, M.Sc from Gauhati Univeristy, M.Tech & Ph.D from IIT Kharagpur, Post- Doctoral Diploma (DTTT) from Tokyo Institute of Technology, Japan under UNESCO Research Fellow (1989-1990) and D.Sc from Gauhati University. He is credited to be the first D.Sc in Chemistry from Gauhati University.

He was a Commonwealth Visiting Fellow in the University of Manchester, UK for one year during October 1997 to September 1998. He is also a member of The Research Board of Advisors, the American Biographical Institute, USA. He was elected President of All India Association of Chemistry Teachers for 3 years from January 2017 to December 2019.

Prof. Dibakar Chandra Deka is the senior most professor in the Department of Chemistry, Gauhati University and served the department as its Head from 2011-2014. In recognition of his services towards chemistry, he has been awarded FRSC by the Royal Society of Chemistry, London in 2016.

Prof.Deka completed and associated with several research projects funded by DST, DBT, UGC, CSIR, etc. he is credited with nearly 70 research papers published in reputed international journals. Prof. Deka has successfully supervised 32 Ph.D Scholars. He has been credited with 3 patents for his works in the field of biodiesel, banana plants, etc. his research interest include natural products, biodiesel and synthetic organic chemistry, etc.

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Helicenes are the ‘first true organic electrocatalyst’ for carbon … – Chemistry World

Helicene electrocatalysts offer a metal-free way to convert carbon dioxide into valuable chemicals. The catalysts drive the process up to 1000 times faster than other organic compounds and represent the first example of a true organic electrocatalyst for carbon dioxide reduction, according to the researchers who developed them.

The team led by Joyanta Choudhury at the Indian Institute of Science Education and Research in Bhopal, found inspiration in the way plants convert carbon dioxide into carbohydrates. Our synthetic molecules mimic the NADP/NADPH system, [in terms of] the central pyridine ring structure and function, he explains.

In photosynthesis, NADPH is a cofactor that efficiently transfers hydrides to captured carbon dioxide molecules, a key step in the formation of sugars and biomass. Over the years, organic hydrides have been used in the reduction of substrates like alkenes, imines, and carbonyl products, adds Choudhury. In this case, Choudhurys team designed a hydride donor based on a helicene structure, to create an artificial NADP analogue that drives the electrocatalytic conversion of carbon dioxide into formate ions.

These organic analogues offer several advantages, among them stability and tuneability. Because of their simpler structures, NADP analogues are also easily accessible in the lab, says Choudhury. Moreover, structural modifications [allow us] to tune their reactivity at wish, he adds.

It features [up to] 1000-fold enhancement of the existing turnover values for similar organic compounds

Joyanta Choudhury,Indian Institute of Science Education and Research, Bhopal

The helicenes are prepared in a one-pot reaction from simple starting materials. Most importantly, the team has reduced the amount of helicenes used in the electrochemical conversion of carbon dioxide to around 1% which is considered a catalytic quantity. It features [up to] 1000-fold enhancement of the existing turnover values for similar organic compounds, adds Choudhury.

Its a significant improvement, and proof of a catalytic system, says Carla Casadevall, an expert in artificial photosynthesis at the University Rovira i Virgili and ICIQ in Tarragona, Spain. Apart from offering a metal-free alternative, [helicenes] regenerate electrochemically following a bio-inspired proton-coupled electron-transfer, she says. Its this process that allows the unusual boost in activity observed. The rational structural design of the helicenes improved its stability and consequently [that of] the electrochemically generated intermediates, she adds.

Although the catalytic process is metal-free, some of the demonstrations required electrodes based on hazardous elements, including mercury. Nevertheless, the authors have also proven the reaction works with simple glassy carbon electrodes, explains Casadevall. This technology is widely used in electrochemistry and had previously been successful in carbon reduction experiments.

According to Casadevall, the next challenges will be to improve the efficiency decreasing the overpotential of the electrocatalytic carbon dioxide reduction and recyclability of the system.

The high overpotential and the stability for long-term electrolysis are still issues to address, acknowledges Choudhury. Currently, the team is attempting to solve these issues by modifying the backbone of the helicene catalyst and adjusting the reaction conditions. Choudhury also notes that the team is exploring applications of helicenes in catalysis beyond electrochemistry, including a photochemical strategy for carbon dioxide reduction.

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Helicenes are the 'first true organic electrocatalyst' for carbon ... - Chemistry World

UM-Flint alum, Citrucel inventor, shares experience with chemistry … – University of Michigan-Flint

A University of Michigan-Flint alum known for his invention of Citrucel and being one of the top 40 most cited scientists in his field recently visited campus and gave a lecture about his love of chemistry and his discoveries in nanomedicine and nanotechnology.

Donald Tomalia, who is originally from Flushing, shared his life story with students and faculty and gave a detailed account about what led him to become a chemist.

"As long as I can remember, I've been curious about what life is, how it works and what its purpose is. Since chemistry is focused on the dynamics, behavior and composition of all matter in the universe, it seemed logical that chemistry would help me find those answers."

After graduating from high school, Tomalia set out in earnest to find those answers. He earned his bachelor's degree in chemistry from UM-Flint in 1961 and then went on to earn a master's degree in the same subject at Bucknell University the same year. After receiving his graduate degree, he began working in the research and development department at Dow Chemical Company where he invented the dietary supplement known as Citrucel in 1962. He went on to receive a PhD in physical-organic chemistry from Michigan State University in 1968 while he was still working at Dow.

Transitioning to a new role as a research fellow at Dow, Tomalia began researching how to create synthetic molecules and polymers that mimicked the growth and appearance of a tree, including its trunk, branches and leaves. This research led to his discovery of dendrimers. Today, dendrimers are found in therapeutic cancer drugs, antiviral agents that protect people from COVID-19, antiviral therapies for HIV and HPV as well as delivery of agrochemicals that enhance crop yields.

As his time at Dow ended, Tomalia launched his first startup company, Dendritech, in 1992. Dendritech, which would be acquired by Dow just six years later in 1998, supplies dendrimers for a device used to diagnose acute heart attacks in less than five minutes as well as anti-fouling paint, or specialized coating applied to ships and boats to slow growth of algae or other aquatic organisms.

His next startup, Dendritic Nanotechnologies was founded in 2001. The company, acquired by Australia's Starpharma in 2006, uses dendrimers to enhance cancer treatment drug delivery, thereby ensuring the drug reaches the right part of the body at the right time.

Tomalia's current company, NanoSynthons LLC, founded in 2010, focuses on the development, production and distribution of high-quality, well-defined carbon molecules.

Tomalia says that his discoveries of dendrimers and building his companies have been a journey.

"I use the term 'journey' as a code word for learning," he said. "I've learned so much along the way. I never thought I would have discovered something as important as dendrimers.'

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UM-Flint alum, Citrucel inventor, shares experience with chemistry ... - University of Michigan-Flint

expert reaction to study looking at volatile organic compounds in a … – Science Media Centre

April 12, 2023

A study published in Cell Reports Physical Science looks at volatile organic compounds in a vehicle cabin environment.

Prof Oliver Jones, Professor of Chemistry, RMIT University in Melbourne, Australia, said:

This is a detailed study that seems to have been conducted thoroughly, in a real-world environment rather than a lab. The authors built a predictive model of the release of the chemicals that cause new car smell and then tested the predictions against measured concentrations.

Many of us like new car smell (myself included). This study doesnt look at health effects of these chemicals, but we know from previous research that some of these chemicals arent really good for us.

New car smell is the result of a chemical process called off-gassing. The term doesnt sound appealing, but it just means the airborne release of a chemical or chemicals as a vapour, in this case from materials such as plastics and adhesives in the cars interior. Such chemicals can include acetaldehyde, benzene, formaldehyde, hexanal, and styrene. Many of these compounds are listed as carcinogenic (cancer-causing), but then so are sunlight and alcohol. It is the dose that makes the poison just because something is present does not automatically mean its a problem; its about quantity (even water is toxic if you drink enough of it). The current paper is focused on ways to better model how much of the chemicals that cause new car smell might be released over time in a car under different conditions.

That said, new car smell is not without risks we know from previous research that for some people it can cause health problems such as dizziness, nausea, and shortness of breath. Healthwise the best new-car smell is probably no smell.

The fact that higher temperatures increase the rate of off-gassing from materials is not new but what is interesting here is that the authors use the surface temperature of the materials to predict the amount of compound that might be released over time rather than the more commonly used metric of air temperature in the cabin. This makes sense when you think about how hot the seats and the steering wheel can get on a hot summer day, especially in places like Australia. A more accurate model gives us a better idea of the likely levels of potentially harmful chemicals over time and this gives us a better idea of the risks which can only be a good thing for drivers.

Observation, prediction, and risk assessment of volatile organic compounds in a vehicle cabin environment by Haimei Wang et al. was published in Cell Reports Physical Science at 16:00 UK time on Wednesday 12 April 2023.

DOI: 10.1016/j.xcrp.2023.101375

Declared interests

Prof Oliver Jones: I have no conflicts of interest to declare.

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How to help students identify electrophiles and nucleophiles – Education in Chemistry

Students need to have a fluency across a range of concepts and skills to gain a secure grasp of organic chemistry. In terms of reaction mechanisms, research has shown that learners frequently have trouble identifying electrophiles and nucleophiles in reactions. Its particularly difficult for students to recognise the relationship between the pictorial depiction of reaction mechanisms and the underlying understanding of electron-deficient and electron-rich species.

Much research in this area has involved interviews with relatively small sample sizes. In a recent study, researchers evaluated nearly 20,000 written explanations of what occurs, and why, in reaction mechanisms to shed further light on students understanding of the processes involved.

Electrophiles, which are electron-deficient, are electron-seeking species.Nucleophiles, which are electron-rich, are nucleus-seeking species. The properties of a given species may be explicit, being depicted pictorially in the form of formal charges, labelled dipoles and lone pairs.

Students perform better in identifying electrophiles and nucleophiles where such explicit features are depicted, but they struggle where properties are implicit (not depicted pictorially). Species with negative charges and/or lone pairs may be easily identified as nucleophiles, while positively-charged species may be identified as electrophiles. Pi-bonds (explicitly depicted) and even some sigma bonds (eg, AlH bonds in LiAlH4), which can be thought of as shared pairs of electrons, have nucleophilic character and can therefore react with electrophiles.

In a chemical reaction, electrophiles and nucleophiles are complementary. An electrophile interacts with a nucleophile during a reaction and vice versa. In previous studies, students were more likely to correctly identify a nucleophile than an electrophile in a reaction.Since chemists need to be able to explain how and why two species interact in a reaction mechanism, its vital they can rationalise the roles of both reacting species. This then facilitates the prediction of the products for a specified reaction.

Students are often asked toreproduce a pictorial reaction mechanism in assessments, which can potentially be rote-learned, resulting in poor understanding of the underpinning theory.Instead, the researchers present a strong case forassessing theexplanation of the mechanism in terms of the interaction between nucleophile and electrophile.

Being able to explain whats happening at a molecular level is the key to understanding the processes involved in a reaction mechanism

The authors created a two-part rubric to evaluate the sophistication of students explanations about electrophiles. This complements a similar rubric they created for nucleophiles. Students had to describe the sequence of events occurring during a reaction mechanism in terms of the roles of reactants and intermediates, and explain their interaction at the molecular level.

The authors created a two-part rubric to evaluate the sophistication of students explanations about electrophiles.Students had to describe the sequence of events occurring during a reaction mechanism in terms of the roles of reactants and intermediates, and explain their interaction at the molecular level.

The researchers categorised the sophistication of student explanations as: absent, descriptive, foundational or complex. Across both electrophiles and nucleophiles, over 54% of responses were classified as descriptive, while nearly 20% were classified as absent, showing room for improvement. Around 54.5% of explanations were at the same level of sophistication for both electrophiles and nucleophiles, and where there was a difference, there was a clear pattern that the electrophile level was lower than the nucleophile level, in line with previous studies.

Being able to explain whats happening at a molecular level is the key to understanding the processes involved in a reaction mechanism. Providing a narrative to accompany the mechanism will help students correctly draw it from first principles.

Reference

Stephanie J H Frostet al,Chem. Educ. Res. Pract., 2023,24, 706-722 (DOI:10.1039/D2RP00327A)

David Read

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[WEBINAR] Scalable Oligonucleotide Manufacture With Stirred-Bed … – Contract Pharma

Based on decades of experience in applying stirred-bed reactors for making peptides, we investigated whether thesecould be used for the manufacturing of oligonucleotides aswell. Join our webinar on scalable oligonucleotidemanufacturing with stirred-bed technology (SBT) to learn howwe can reach commercial oligonucleotides API production inmetric ton range with unbeaten process mass intensity. You willget insights into case studies, our SBT capacities for R&D tolarge scale production projects, and typical CMC activities forscale-up. Finally, we will share the distinct advantagesstirred-bed solid-phase oligonucleotide synthesis (SPOS) hasover classical fixed-bed SPOS.

Speakers:

Daniel Samson, PH.D. - Vice President, Head Oligonucleotides

Daniel brings 15 years of industry experience to the team, with an emphasis on TIDES process R&D, manufacturing and CMC development. He leads Bachems oligonucleotide unit including innovation projects, R&D and manufacturing activities. Daniel holds a PhD in organic chemistry from the University of Konstanz, and an MBA from the International Institute for Management Development (IMD), Lausanne. In previous stages of his career he was a lab head for process optimization, technology transfer, Quality by Design, and scale-up of synthetic peptide manufacturing procedures. From 2012, Daniel was a Vice President API Manufacturing and had full responsibility for all large-scale solid phase peptide and oligonucleotide syntheses, downstream operations, and CMC activities within Bachem AG.

Chris Mcgee, PH.D. - Vice President, Head Global Business Development

Chris leads the Global Business Development department at Bachem. Previously, he was Senior Director of Business Development (BD) for Bachem Americas. As Senior Director of BD, he was at the forefront of communications related to the development and manufacturing of new peptide and oligonucleotide-based chemical entities with his team of peptide experts in the field. Chris has nearly a decade of experience at Bachem and previously earned a Ph.D. in organic chemistry from the University of California, Irvine.

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Maximizing the Up-Time inour Lab While Reducing Costs of … – Spectroscopy Online

UV-Vis technology is used to analyze, characterize, and quantify pharmaceutical and biological samples. Join Agilent to discuss the benefits of improving workflows in the pharmaceutical industry utilizing new UV-Vis spectrophotometer technology.

Register Free: https://www.spectroscopyonline.com/spec_w/up-time

Event Overview:

UV-Vis spectroscopy is a mature technology used to analyze, characterize, and quantify pharmaceutical and biological samples such as active pharmaceutical ingredients, DNA/RNA, and proteins for many decades. The use of UV-Vis has been limited by the workflow needed to make these measurements efficiently. The recent advances in UV-Vis spectroscopy focus on enhancing laboratory productivity, offering ease of use, and providing multiple accessories designed specifically for application needs. Pharmaceutical and biopharmaceutical materials have become more sophisticated in life science research across fields (such as cancer research, drug development, vaccines, and quality control in regulated environments). The technology used for the analysis should evolve, too. This webinar will highlight the benefit of the new Agilent Cary 3500 Flexible UV-Vis spectrophotometer and its capabilities in improving workflows in the pharmaceutical industry.

Key Learning Objectives:

Who Should Attend:

Speaker:

Geethika WeragodaApplication ScientistAgilent TechnologiesAustralia Pty Ltd

Geethika Weragoda has a PhD in physical organic chemistry and photochemistry from the University of Cincinnati. Her PhD research focused on the study of reactive intermediates and their transformation using transient spectroscopy and theoretical calculations. During this time, she joined Hiroshima University in Japan as a research scholar to study laser spectroscopic techniques. After moving to Australia, she completed a postdoctoral fellowship at the CSIRO, developing photocatalytic pathways for C-H functionalization. Geethi is currently an applications scientist at Agilent Technologies.

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Arkansas Space Grant Consortium grant awarded to SAU Chemistry and Agriculture Departments Is a Martian greenhouse possible? – SAU

The Arkansas Space Grant Consortium board voted to fund Dr. Gija Geme, Dr. Tim Schroeder of chemistry, and Dr. Copie Moore of agriculture on a joint venture to explore the feasibility of growing crops such as soybeans, corn, lettuce, kale, and more, in a Mars soil simulant that is improved with fertilizer to add micronutrients. The team received $50,000 from NASA funding through Arkansas Space Grant Consortium in the spring of 2023.

This project aims to measure heavy metal uptake by plants using Inductively Coupled Plasma (ICP) Spectroscopy analysis. The soil on Mars is almost entirely made up of mineral matter with small amounts of water and no organic matter. NASAs Mars rover, Curiosity, showed that the mineral matter in Martian soil comes from the weathered volcanic rock of mineralogy similar to weathered basaltic soils of volcanic origin in Hawaii. Martian soil is reddish and sandy overall because it contains a significant amount of iron oxides (rust) throughout the planets surface since global dust storms move and redistribute the soil. The toxically high concentration of heavy metals in the soil will be reflected by higher concentrations of metals in plants.

Dr. Adbel Bachri, dean of the College of Science and Engineering, stated, The proposed research is very relevant to NASA plant researchers Exploration of Deep-Space Food Crops and will contribute to answering an important question: Is a Martian greenhouse possible? Bachri also noted that the Mars Exploration Program specifically aims to explore Mars as a possible destination for the survival of humankind in the future.

This unique project will involve undergraduate students from both departments as they simulate the soil of Mars, grow crops, and test for the presence of heavy metals in them. The acquisition of an ICP instrument through this grant will enhance the Natural Resources Research Center (NRRC) service to local area specialty chemical industries and boost its capability for water testing and soil chemistry.

SAU NRRC is an approximately 3,000-square-foot building and is a core facility funded jointly by Southern Arkansas University and a grant from the Department of Commerce through the Arkansas Economic Development Administration. The NRRC consists of seven separate laboratories equipped with state-of-the-art analytical instrumentation to meet the needs of industries, public agencies, and private citizens in southwest Arkansas. NRRC is also ADEQ-certified for water and soil analysis and provides chemistry consulting and research and development services via analytical methods. The NRRC currently provides waste-water testing to the cities of Magnolia, AR, and Waldo, AR. The NRRC also contracts projects from surrounding specialty chemicals industries in Southwest AR.

NRRC: https://web.saumag.edu/science/nrrc/

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Arkansas Space Grant Consortium grant awarded to SAU Chemistry and Agriculture Departments Is a Martian greenhouse possible? - SAU

Organic Electronics Market is expected to reach US$ 1705.1 Bn by … – Market Research Blog

By the end of 2021, theorganic electronics marketgenerated US$ 96.9 billion in revenue. The organic electronics market is anticipated to grow at a CAGR of 29.9% from 2022 to 2032, reaching US$ 1,705.1 Bn.

The use of organic molecules and specific types of polymers, which have the capacity to conduct electricity, in the development of semiconductors, electricity-conducting circuits, and electronic devices is known as organic electronics.

The organic electronic market is expanding as a result of advancements in polymer and organic chemistry. The market is still in its infancy and will take some time to develop, but as it finds uses in consumer electronics and healthcare, the market will undoubtedly expand.

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The organic electronics market refers to the use of organic materials in the development of electronic devices. Organic materials, such as carbon-based polymers, offer several advantages over traditional inorganic materials, such as silicon, including flexibility, low cost, and ease of manufacturing.

The global organic electronics market is expected to grow significantly in the coming years, driven by the increasing demand for organic materials in various industries, including healthcare, energy, and consumer electronics. The market is also expected to benefit from the increasing focus on sustainable and environmentally friendly materials.

Organic electronics have already found applications in various devices, including organic light-emitting diodes (OLEDs), organic photovoltaic (OPV) cells, organic thin-film transistors (OTFTs), and sensors. OLEDs are widely used in displays for mobile phones, televisions, and other electronic devices, while OPV cells are used for generating electricity from sunlight.

Overall, the organic electronics market is expected to continue to grow in the coming years, driven by the increasing demand for flexible, low-cost, and sustainable electronic devices.

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Competitive Landscape

Companies currently developing organic electronics are chemical companies that develop organic materials like polymers and polycarbonates, which could be developed into creating organic electronic components.

Regional Analysis

In 2021, North America had the largest market share of35.2%, and South Asia and the Pacific are estimated to have the fastest growth rate of CAGR at32.7%.

Several organic companies which are developing organic electronic components are in North America, and this will fuel the growth of organic electronics. North America also has a large healthcare and medicine industry and manufacturing industry, which will allow the market to grow.

South Asia and the Pacific are witnessing a growth in the manufacturing and implementation of solar cells and batteries for providing electricity for country-wide purposes. The consumer electronics market in this region is also huge. For this reason, South Asia and the Pacific is the fastest growing region.

Organic Electronics by Category

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Science and Fiction Are Experiments That Ask the Same Question – Electric Literature

When I was a teenager, my uncle Jesse Ausubel decided to count all the fish in the sea.

Hes not crazy. The Census of Marine Life, which Jesse conceived of with a colleague one July afternoon in the late 90s, is the story of the oceans, past, present, and future. It was an unprecedented ten-year, eighty-nation project conducted by marine scientists the world overChinese zooplankton researchers and Venezuelans renowned for their study of the sex lives of snails. Many Census research trips turned up more unknown species than known, like the organisms resembling blown-glass human hearts, seen for the first time on the icy Antarctic Ocean floor alongside sea spiders and the perfectly named Blob Fish.

Dear Ramona,Good Sunday morning from Kerala. For breakfast I had a masala dosa, sambar, cucumber juice, both a mango and a strawberry lassi, and two cups of hot milky chai.We are having a conference about the Census of Marine Life in the Indian Ocean region. Yesterday I met with some of the worlds top experts on barnacles.Hope to go for an elephant ride before zooming back to the USA.LoveJesse

My uncle lives in the land of questions that are just this side of unanswerable.

Meanwhile, Id enrolled in an MFA program in southern California, where I wrote stories about a girl who thought she would give birth to an eagle and a place where people grew new arms when they fell in love. I was in my mid-twenties and as a writer, I committed myself to an examination of the way it feels to be human in a hard, strange world. Each question I asked, each story I wrote, felt like a kind of magnifying glass over the curious landscape of the heart.

In my fiction workshop we talked about the mechanics of one anothers stories and asked, What if you tried . . . ? How would it work if . . . ? All of us in the program were tunneling into our own minds, emerging experts in our ways of seeingand the rest of us were there to keep asking questions to push every voice closer to itself.

Each question I asked, each story I wrote, felt like a kind of magnifying glass over the curious landscape of the heart.

During these years I lived with my sweetie (now my husband) in a tiny hand-built above-garage apartment on an island in the middle of a fancy southern California harbor. We bought an eight-foot sailing dinghy at a yard sale for $100 and on the weekends, we floated between yachts and houses built recently to look like ancient Italian palazzos: columns, topiaries, plaster scraped and painted to look weathered. The houses all faced water-ward, shouting their wealth and grandeur to the Pacific. What if we are the best? What if we are the most beautiful? they seemed to ask. Teo and I drank cheap wine and ate candy in our tiny boat. We didnt have any extra money but I savored the idea that the University of California was paying me to be a graduate student who turned strange questions into strange stories. I could observe other peoples lives and turn their details into material. I was so lucky. I was getting away with something delicious. Rich people drank better wine on great lawns but we were so close to the water that I could reach my hand down and touch it.

I first met members of the Census of Marine Life Scientific Steering Committee in Panama in 2007. Jesse had invited me and my grandmother. Grammy Anne was a mere baby at eighty-six; now she is 103. At a party at Miraflores Locks in the Panama Canal, where we munched empanadas and watched huge ships cross the thin waist of the Americas, Jesse introduced us around.

We met a woman who had just retired after nearly forty years of oceanographic research, much of it riding submersibles through the deep blue. There was a tropical marine ecologist from Australia, a Chinese zooplankton researcher, a Canadian fisheries expert, a Belgian benthic ecologist. Grammy Anne flitted aboutshe is small and fast moving, like a shorebirdand made everyone laugh. If theres one thing I love, its predators, she said. She told the scientists how impressed she was with their workI call it the Saving the World Business. She also pretended to wave off her sons accolades again and again. I didnt do anything, she said, but she was glowing with pride when she said it. When someone asked me what I did, I felt a wave of uncertainty. I answered with a question, I write fiction? because against all their knowledge and accomplishments, making things up for very meager money seemed so tiny as to be nearly ridiculous.

Instead of organic chemistry, I had taken a class called The History of Laughter in college. My brain lets go of facts easily, like it is releasing seeds to the wind. Precision was not my love language. I identified as an artist, all my talent based in intuition and feeling (and persistence).

The next day I joined a small group of oceanographers on a daytrip to Barro Colorado, a research island operated by the Smithsonian Institute in the middle of the Panama Canal. As we tromped through the jungle, our pants tied up around our ankles to keep the ticks out (an ineffectual technique, I discovered that night), a family of monkeys shook the trees above us. A baby the size of a kitten watched us big lumbering beasts below. The big lumbering beasts, scientists or not, squealed in excitement. As we walked on, I listened to conversations ranging from decapods to the sound lava makes when it hits the ocean. These people had been working for decadescataloguing, studying, writing papers, teaching. But their subjects lived underwaterhere on land, they were no more informed than I was. They referred to everything as terrestrial. Someone found a little round object on the ground. If this had been a coral, an anemone, a sea-fan, an urchin, one of our group might have been able to tell us the minutia of how it ate, how it grew, how it reproduced. Instead, the finder said, Is this some kind of strange fungus? It seemed pretty clear to me that it was a nut.

I identified as an artist, all my talent based in intuition and feeling (and persistence).

Here I was, walking through the jungle, monkeys above and ticks below, with members of my species who had defectedexpatriated, at least in their minds and heartto the sea. Looking up into the trees for them was like looking down into the seagrass and coral for the rest of us. Can you believe what were seeing? Can you believe this has been here all along?

We were amateurs, our appreciation dumb but beautiful. That day we were land fans, waving our imaginary foam fingers for the anteater hoovering insects out of the tree bark, for the vines that braided the forest.

Back in my island shack, I started a novel. It took place in northern Romania where my grandmother had spent her childhood. I wanted to imagine my way to that place, to a part of my history that both belonged to me and felt impossibly distant. I began with research and interviews and facts but after months of writing, the gas tank sputtered empty. The only way to go to that place, the only way I could reach for it, was to imagine my way inside. What if, what if, what if?

I went to workshop where we talked about stories in which mothers died, stories in which people fell in love, stories in which all the towns babysitters got pregnant at the same time. We asked one anothers stories to trust their own logic, to rise to their own heights. When I think about it now, it almost makes me want to cry with appreciation, how carefully we paid attention to one anothers work, how much that group of twelve other humans created a warm place for my weird worlds to begin to exist. Our table was a kind of lab, beakers and petri dishes and droppers. We paid such close attention and we kept on trying. Every week something new came to life.

Dear Ramona,Last week I was in Italy in the garden of poisonous plants in Padova and then in Florence and Rome.Week before in British Columbia seaplane-ing about to implant radio tags in young salmon.Will be in DC, MV, and Ontario before heading to Ecuador.LoveJesse

When I was in my last year of graduate school Jesse invited Grammy Anne and I to China to attend another Census of Marine Life meeting. Youre in China, mother! he cooed. Do you feel like the Dowager Empress? he asked. Her feet were so swollen from the trans-Pacific flight that she could not get her shoes on, and she pointed to her stockinged feet and laughed.

We joined the scientists for a dream-like, jet-lagged welcome banquet. Food appeared constantly and silently on our table. Freshwater fish in a briny vinegar sauce. Lotus roots deep fried and glistening. The petals of a lily stir-fried with asparagus. Ginko nuts, bright yellow and soft like beans. Beef, chicken, duck, pork, giant clam. Thick balls of sticky black rice sweetened and flavored with almond. Even though I was what my grandmother would call a good eater, everything was a little bit unfamiliar, in the best way. The flavors reminded me that there is much more unknown than there is known. What luck to live in such a world.

Template for a Proclamation to Save the Species by Ramona Ausubel, recommended by ManuelGonzales

Mar 21 Ramona Ausubel

As we ate, I kept hearing words that felt weirdly familiarcould we try . . . ? How would it work if . . . ? The conversation among scientists sounded an awful lot like a writing workshop. While we writers What If-ed our way to the best point of view for a story about a mythical bathhouse, this team was What-If-ing their way to a baseline understanding of everything alive in the ocean. The asking of questions, wondering, pressing at the edges was as much a part of science as the laboratory. The questions would lead them toward facts and something exact. The completed Census of Marine Life is full of precision (as much as possible), but in order to offer that knowledge, the team had to start with a vision, a desire, an imagining of things that could be.

Dear Ramona,Hi from Adelaide, South Australia. Tomorrow morning I will spend in the national botanical garden, looking at plants that cant exist according to the Known World.LoveJesse

There is plenty of terrible news about life lost under the sea and on land. We are facing one of the largest mass extinctions in our planets history. And yet, and also, life is endlessly inventive: one liter of seawater drawn up from 1,500 meters in the Northeast Pacific contained twenty thousand kinds of bacteria, most of which were unknown and likely rare. A shrimp, believed to have gone extinct some fifty million years ago, was discovered in the Coral Sea. The creature was alive and well, and unaware that the record book had logged the end of its existence at the same time as the dinosaurs.

Life survivesthrives happily and fruitfullyin conditions that seem impossible. In a thermal vent near the equator in the Atlantic Ocean, members of the Census Vents and Seeps team (sign me up and get me a T-shirt!) measured the water temperature at a leada nearly zinc-melting 407 degrees Celsius. This is the hottest vent on record, and still life goes on. Shrimp, clams, and bacteria enjoy the blue-plate specialfreshly magma-broiled, sulfur-rich water spewing out in black clouds.

Some of those deep vents, where organic compounds, heat and minerals, were pushed out over thousands of years are likely to have been the incubators of all life on Earthfrom the nearly blind shrimp who live there still to the Siberian tiger; from the elephant seal to the guy in the checkout aisle in front of me with a shopping cart full of cottage cheese and canned beans.

Jesse was traveling with an Arctic expedition that was looking at life under the ice in the Canada Basin, which had never been explored for biological life before and was assumed by many to be an icy desert. There are many pictures of him grinning in his huge orange suit; in one I especially love, he is making a snow angel while scientists around him take ice samples. Lo and behold, a desert it was not. The creatures the expedition discovered were so delicate, their bodies such thin membranes, that they looked like they might dissolve. In fact, these creatures were living happily in some of the most difficult conditions on earth. Jesse said, It was like descending through a universe made with the supreme sensual artistry of the glassblowers of Murano. There were iridescent green sea cucumbers and a clear siphonophore (what looks like an electrified stalk of lily-of-the-valley with a comets tail of fire). No matter what weird story I ever come up with, I will never be as inventive as nature. The ocean is the ultimate surrealist.

No matter what weird story I ever come up with, I will never be as inventive as nature.

After our welcome banquet in China, we walked along a busy shopping street to digest our feast. Neon signs lit the air, which was so thick with pollution, I could almost see the particles. The Olympics were slated to take place in Beijing the following summer and a billboard for the Chinese national volleyball team proclaimed Impossible Is Nothing. Construction was moving ahead at lightning speeda hotel at the end of the block looked significantly more built then, at the end of the day, than it had when wed set out that morning. The new terminal at Beijing International, one of the biggest buildings in the world, took just four years to complete.

Soon, in a many-armed attempt to clear the sky for the Games, all construction would stop, traffic would be severely regulated, and a project would commence of trying to make it rain by seeding the clouds with silver iodide. What if . . . ? The human imagination plus chemistry plus money, and actual water falls from the actual sky.

Dear Ramona,We are working our Oceans movie out here in the southwest Pacific. We filmed until 3 AM last night on a coral reefgot some good footage of yellow-lipped sea snakes (tricot rave in French). I will return to NYC for T-giving if a cyclone around Papua does not interfere. There could be worse things than to be stranded on a tropical island . . . .LoveJesse

Years later, I lay in bed nursing my new baby girl. It was raining and had been for weeks. Everything felt slightly surreal, this creature in my arms that had never existed until right then; in the other room my older child laughed hysterically while trying evade pants. I felt the high shine of absolute joy, and I was tired in a way that was bottomless. What a life, I thought. What a species. How could we ever encapsulate it all? How could we ever even name it?

I opened my laptop and a news story appeared: Team Plans to Bring Back the Woolly Mammoth. I pictured a huge hairy pachyderm in my California backyard, grazing on the bamboo. I pictured the steel-and-glass laboratory in which elephant DNA was apparently being edited to look like mammoth DNA. Really? I thought. Really, really?

I did not know what it might it feel like to care for a prehistoric beast, but I had an alien creature in my lap and I was falling quickly in love with herso what if she happened to be human? The heart is capable of strange and amazing things, to say nothing of the mind.

What if? I asked. What if, what if?

Like all stories, like all inventions, we start there.

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Science and Fiction Are Experiments That Ask the Same Question - Electric Literature