Category Archives: Neuroscience

Study: People who felt their life was guided by meaningful values or goals were more willing to engage in COVID-19 protective behaviors – YubaNet

Why can some people weather the stress of social isolation better than others, and what implications does this have for their health? New research from the Communication Neuroscience Lab at the Annenberg School for Communication at the University of Pennsylvania found that people who felt a strong sense of purpose in life were less lonely during the COVID-19 pandemic. Did they achieve less loneliness by flouting public health guidance? No. Although lonelier people were less likely to want to follow public health guidance, people with a stronger sense of purpose also expressed more willingness to engage in social distancing, hand washing, and other COVID-19 protective behaviors.

Purpose in life, or a sense that your life is guided by personally meaningful values and goals which could involve family ties, religion, activism, parenthood, career or artistic ambitions, or many other things has been associated in prior research with a wide range of positive health outcomes, both physical and psychological.

In the face of adversity, people with a stronger sense of purpose in life tend to be more resilient because they have a clear sense of goals that motivate actions that are aligned with personal values, says Yoona Kang, Ph.D., lead author and a Research Director of the Communication Neuroscience Lab. People with strong purpose may also experience less conflict when making health decisions. We felt that the COVID-19 pandemic was an important context to test whether purpose in life relates to individuals willingness to engage in behaviors to protect themselves and others.

Based on their prior research, Kang and her collaborators expected that people with higher sense of purpose would be more likely to engage in COVID-19 prevention behaviors than individuals with a lower sense of purpose. In order to test their theory, the researchers surveyed more than 500 adult participants to capture their levels of purpose in life, their current and pre-pandemic levels of loneliness, and the degrees to which they intended to engage in behaviors known to prevent the spread of COVID-19.

They found that higher levels of loneliness made people be less focused on protecting themselves from COVID-19, and more skeptical that behaviors to prevent COVID-19 would be effective. However, having a stronger sense of purpose was associated with lower levels of loneliness and a greater desire to take action to protect themselves from COVID-19. Those with a higher sense of purpose also expressed a stronger belief that COVID-19 prevention behaviors would work. Even when people who had a strong sense of purpose did report being lonely, they still felt strongly about taking precautions to prevent COVID-19.

When faced with extreme loneliness and social isolation, like during the COVID-19 pandemic, wanting to connect with other people, despite the health risks, is a natural response, Kang says. And yet, amidst this drastic shift in social life, we found that people with a higher sense of purpose were more likely to engage in prevention behaviors. This is striking because it shows that purpose in life can empower people to make life-saving health decisions that protect their own health and those around them.

Additionally, the researchers found that older people expressed less loneliness during the COVID-19 pandemic than younger people. Kang sees this as a sign of the resilience of older adults, and she hopes to further study how to enhance purpose in life and resilience in aging populations.

Having a stronger sense of purpose was associated with really important, positive outcomes across the lifespan, says Emily Falk, senior author, Director of the Communication Neuroscience Lab, and Professor of Communication, Psychology, and Marketing. Our upcoming work will test interventions to increase their sense of purpose, in hopes of bringing these benefits to more people.

The study, published yesterdayinThe Gerontologist, is entitled Purpose in Life, Loneliness, and Protective Health Behaviors during the COVID-19 Pandemic, and is available here.In addition to Kang and Falk, authors include Danielle Cosme, Ph.D.; Rui Pei, Ph.D.; Prateekshit Pandey; and Jos Carreras-Tartak.

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Study: People who felt their life was guided by meaningful values or goals were more willing to engage in COVID-19 protective behaviors - YubaNet

Here’s how stress during coronavirus pandemic linked to poor sleep – Hindustan Times

The findings of a study on hundreds of twins led by Washington State University researchers suggest that stress, anxiety and depression during the first few weeks of the pandemic were associated with less and lower quality sleep.

The study was published in Frontiers in Neuroscience. In a survey of more than 900 twins taken shortly after COVID-19 lockdown measures began, about half of the respondents reported no change in their sleep patterns, but around a third, 32.9 per cent, reported decreased sleep.

Another 29.8 per cent reported sleeping more. In the analysis, the researchers found that any change in sleep was connected to self-reported mental health issues, though it was more strongly associated with decreased sleep.

"The results show that deviations from your typical sleep behavior may be associated with depression, anxiety and stress," said Siny Tsang, lead author on the study published in Frontiers in Neuroscience.

Tsang, a staff scientist with the WSU Elson S. Floyd College of Medicine, emphasized that this showed a connection, not a cause, but the study supports previous research that has found a two-way relationship between disrupted sleep patterns and poor mental health.

In other words, when people don't sleep well, they are more likely to feel stress, anxiety and depression, and when they are dealing with those same problems, they are more likely to sleep less--and sometimes more--than the typical six to nine hours a night.

This study analyzes survey responses collected between March 26 and April 5, 2020, from participants in the Washington State Twin Registry. Since then, the same group has answered three more waves of survey questions.

Researchers are particularly interested in studying twins, so they can investigate whether associations are mediated by genetic factors, shared environment, or both. The pandemic also offered an opportunity for a natural experiment to see how a stressful situation affects sleep amount and quality among individuals in the community, Tsang said.

The research relies on the self-reported perception of sleep length and quality, but the researcher said that when it comes to mental health, perception can matter more than the real amount of sleep.

"Even if your cell phone says you consistently sleep eight hours every day, you may feel that you slept less or slept poorly, and that may be linked to stressful or anxious feelings," Tsang said. "It may not matter whether or not the actual number has changed. It's how you are feeling that is associated with your mental health."

WSU researchers have also conducted twin studies on COVID-19 lockdown effects on alcohol use and pandemic stress and exercise. These have all been initial studies taken at the early stages of the pandemic and associated social distancing measures. The scientists are still analyzing the results of later surveys, but they are starting to see a common theme.

"A pattern that is consistent across these three studies is that people who reported change in physical exercise, alcohol use or sleep are more stressed, anxious and depressed than those who had said that they have had no change," Tsang said.

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Here's how stress during coronavirus pandemic linked to poor sleep - Hindustan Times

Zhongchao Inc. Partners with a Subsidiary of AbbVie Inc. (NYSE: ABBV) for Medical Education Services – BioSpace

SHANGHAI, June 16, 2021 /PRNewswire/ -- Zhongchao Inc. (NASDAQ: ZCMD) ("Zhongchao" or the "Company"), a healthcare services company offering online healthcare information, professional training and educational services, today announced the cooperation in physician education with AbbVie Pharmaceutical Trading (Shanghai) Co., Ltd. ("AbbVie Shanghai"), a subsidiary of AbbVie Inc (NYSE: ABBV) ("AbbVie"). AbbVie is a research-based global biopharmaceutical company. Pursuant to an agreement to facilitate such cooperation, Zhongchao and AbbVie Shanghai will cooperate in, including but not limited to, developing the medical education contents and producing medical education courses.

Weiguang Yang, Chairman and Chief Executive Officer of Zhongchao, commented, "AbbVie is one of the top ten global research-oriented biopharmaceutical companies with numerous innovations in the core field of immunology, oncology, neuroscience, and Allergan Aesthetics. In recent years, AbbVie has introduced more and more innovative therapies and drugs to the Chinese market, benefitting Chinese patients. We are honored to cooperate with AbbVie Shanghai to promote the development of medical education."

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. They strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit http://www.abbvie.com.

About Zhongchao Inc.

Incorporated in 2012 with headquarter offices in Shanghai and Beijing, China, Zhongchao Inc. is an online provider of healthcare information, professional training and educational services to healthcare professionals under its "MDMOOC" platform (www.mdmooc.org) and to the public under its "Sunshine Health Forums" platform (www.ygjkclass.com) in China. More information about the Company can be found at its investor relations website at http://izcmd.com.

Safe Harbor Statement

This press release contains forward-looking statements as defined by the Private Securities Litigation Reform Act of 1995. Forward-looking statements include statements concerning plans, objectives, goals, strategies, future events or performance, and underlying assumptions and other statements that are other than statements of historical facts. When the Company uses words such as "may," "will," "intend," "should," "believe," "expect," "anticipate," "project," "estimate" or similar expressions that do not relate solely to historical matters, it is making forward-looking statements. Forward-looking statements are not guarantees of future performance and involve risks and uncertainties that may cause the actual results to differ materially from the Company's expectations discussed in the forward-looking statements. These statements are subject to uncertainties and risks including, but not limited to, the following: the Company's goals and strategies; the Company's future business development; product and service demand and acceptance; changes in technology; economic conditions; the growth of the professional training and educational services market in China and the other international markets the Company plans to serve; reputation and brand; the impact of competition and pricing; government regulations; fluctuations in general economic and business conditions in China and the international markets the Company plans to serve and assumptions underlying or related to any of the foregoing and other risks contained in reports filed by the Company with the SEC, the length and severity of the recent coronavirus outbreak, including its impacts across our business and operations. For these reasons, among others, investors are cautioned not to place undue reliance upon any forward-looking statements in this press release. Additional factors are discussed in the Company's filings with the SEC, which are available for review at http://www.sec.gov. The Company undertakes no obligation to publicly revise these forwardlooking statements to reflect events or circumstances that arise after the date hereof.

For more information, please contact:

At the Company: Pei Xu, CFOEmail: xupei@mdmooc.orgPhone: +86 21-3220-5987

Investor Relations: Sherry ZhengWeitian Group LLCEmail: shunyu.zheng@weitian-ir.comPhone: +1 718-213-7386

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SOURCE Zhongchao Inc.

Company Codes: NASDAQ-NMS:ZCMD

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Zhongchao Inc. Partners with a Subsidiary of AbbVie Inc. (NYSE: ABBV) for Medical Education Services - BioSpace

BioXcel Therapeutics to Host Virtual Commercial Day on June 25, 2021Live webcast to be held on June 25th from 12:00 PM ET 1:30 PM ET – BioSpace

NEW HAVEN, Conn., June 18, 2021 (GLOBE NEWSWIRE) -- BioXcel Therapeutics, Inc. ("BioXcel" or the "Company") (Nasdaq: BTAI), a clinical-stage biopharmaceutical company utilizing artificial intelligence approaches to develop transformative medicines in neuroscience and immuno-oncology, today announced that the Company will host a virtual Commercial Day on Friday, June 25, 2021, from 12:00 PM ET 1:30 PM ET.

The event aims to provide an update on the Companys launch readiness plans and market insights for BXCL501, an investigational, proprietary, orally dissolving thin film formulation of dexmedetomidine for the acute treatment of agitation associated with schizophrenia and bipolar disorders I and II in adults, along with a key opinion leader clinical perspective.

Vimal Mehta, Ph.D., Chief Executive Officer, and Will Kane, Chief Commercial Officer, will be joined by members of the Companys commercial leadership team, as well as industry expert, Dr. Leslie S. Zun, Professor of Emergency Medicine at Chicago Medical School.

A live webcast of the event and the accompanying presentation materials will be accessible through the investors section of the Companys website at http://www.bioxceltherapeutics.com on June 25th at 12:00 PM ET. Following the event, the webcast will be archived on the Companys website for at least 30 days.

About BXCL501

BXCL501 is an investigational, proprietary, orally dissolving thin film formulation of dexmedetomidine, a selective alpha-2a receptor agonist for the treatment of agitation and opioid withdrawal symptoms. BioXcel believes that BXCL501 potentially targets a causal agitation mechanism, and the Company has observed anti-agitation results in multiple clinical studies across several neuropsychiatric disorders, including schizophrenia related agitation (SERENITY I), bipolar disorder related agitation (SERENITY II) and dementia related agitation (TRANQUILITY). BXCL501 has been granted Breakthrough Therapy designation for the acute treatment of agitation associated with dementia and Fast Track designation for the acute treatment of agitation associated with schizophrenia, bipolar disorders and dementia. The Company recently received acceptance of its New Drug Application for BXCL501 for the acute treatment of agitation associated with schizophrenia and bipolar disorders. The safety and efficacy of BXCL501 has not been established.

About BioXcel Therapeutics, Inc.

BioXcel Therapeutics, Inc. is a clinical-stage biopharmaceutical company utilizing artificial intelligence approaches to develop transformative medicines in neuroscience and immuno-oncology. BioXcels drug re-innovation approach leverages existing approved drugs and/or clinically validated product candidates together with big data and proprietary machine learning algorithms to identify new therapeutic indices. BioXcels two most advanced clinical development programs are BXCL501, an investigational, proprietary, orally dissolving thin film formulation of dexmedetomidine for the treatment of agitation and opioid withdrawal symptoms, and BXCL701, an investigational, orally administered, systemic innate immunity activator in development for the treatment of aggressive forms of prostate cancer and advanced solid tumors that are refractory or treatment nave to checkpoint inhibitors. For more information, please visit http://www.bioxceltherapeutics.com.

Contact Information:

BioXcel Therapeutics, Inc.www.bioxceltherapeutics.com

Investor Relations:Mary ColemanBioXcel Therapeutics, VP of Investment RelationsMColeman@bioxceltherapeutics.com1.475.238.6837

John GrazianoSolebury Troutjgraziano@soleburytrout.com1.646.378.2942

Media:

Julia DeutschSolebury Troutjdeutsch@soleburytrout.com1.646.378.2967

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BioXcel Therapeutics to Host Virtual Commercial Day on June 25, 2021Live webcast to be held on June 25th from 12:00 PM ET 1:30 PM ET - BioSpace

Depression, anxiety during pandemic linked to poor sleep – Devdiscourse

Anxiety and depression during the first few weeks of the pandemic were associated with less and lower quality sleep, as per the findings of a study conducted on hundreds of twins led by Washington State University researchers. The study was published in Frontiers in Neuroscience. In a survey of more than 900 twins taken shortly after COVID-19 lockdown measures began, about half of the respondents reported no change in their sleep patterns, but around a third, 32.9 per cent, reported decreased sleep.

Another 29.8 per cent reported sleeping more. In the analysis, the researchers found that any change in sleep was connected to self-reported mental health issues, though it was more strongly associated with decreased sleep. "The results show that deviations from your typical sleep behavior may be associated with depression, anxiety and stress," said Siny Tsang, lead author on the study published in Frontiers in Neuroscience.

Tsang, a staff scientist with the WSU Elson S. Floyd College of Medicine, emphasised that this showed a connection, not a cause, but the study supports previous research that has found a two-way relationship between disrupted sleep patterns and poor mental health. In other words, when people do not sleep well, they are more likely to feel stress, anxiety and depression, and when they are dealing with those same problems, they are more likely to sleep less--and sometimes more--than the typical six to nine hours a night.

This study analyses survey responses collected between March 26 and April 5, 2020, from participants in the Washington State Twin Registry. Since then, the same group has answered three more waves of survey questions. Researchers are particularly interested in studying twins, so they can investigate whether associations are mediated by genetic factors, shared environment, or both. The pandemic also offered an opportunity for a natural experiment to see how a stressful situation affects sleep amount and quality among individuals in the community, Tsang said.

The research relies on the self-reported perception of sleep length and quality, but the researcher said that when it comes to mental health, perception can matter more than the real amount of sleep. "Even if your cell phone says you consistently sleep eight hours every day, you may feel that you slept less or slept poorly, and that may be linked to stressful or anxious feelings," Tsang said. "It may not matter whether or not the actual number has changed. It's how you are feeling that is associated with your mental health."

WSU researchers have also conducted twin studies on COVID-19 lockdown effects on alcohol use and pandemic stress and exercise. These have all been initial studies taken at the early stages of the pandemic and associated social distancing measures. The scientists are still analysing the results of later surveys, but they are starting to see a common theme. "A pattern that is consistent across these three studies is that people who reported change in physical exercise, alcohol use or sleep are more stressed, anxious and depressed than those who had said that they have had no change," Tsang said. (ANI)

(This story has not been edited by Devdiscourse staff and is auto-generated from a syndicated feed.)

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Depression, anxiety during pandemic linked to poor sleep - Devdiscourse

New research finds compound that blocks Covid-19 virus and protects lung cells – Hindustan Times

Research conducted at Louisiana State University Health New Orleans Neuroscience Center of Excellence reports that 'Elovanoids', bioactive chemical messengers made from omega-3 very-long-chain polyunsaturated fatty acids, may block the virus that causes Covid-19 from entering cells and protect the air cells (alveoli) of the lung.

The findings of the research are published in the journal Scientific Reports.

"Because the compounds are protective against damage in the brain and retina of the eye and the Covid-19 virus clearly damages the lung, the experiment tested if the compounds would also protect the lung," noted Nicolas Bazan, MD, PhD, Director of the LSU Health New Orleans Neuroscience Center and senior author of the paper.

The research team tested Elovanoids (ELVs) on infected lung tissue from a 78-year-old man in petri dish cultures. They found that ELVs not only reduced the ability of the SARS-CoV-2 spike protein to bind to receptors and enter cells, but they also triggered the production of protective, anti-inflammatory proteins that counteract lung damage.

The scientists report that ELVs decreased the production of ACE2. ACE2 is a protein on the surface of many cell types. ACE2 receptors act like locks on cells, and the SARS-CoV-2 spike proteins act like keys that open the locks letting the virus enter cells to multiply rapidly. They also demonstrated for the first time that alveolar cells are endowed with pathways for the biosynthesis of ELVs.

"Since SARS-CoV-2 affects nasal mucosa, the GI tract, the eye, and the nervous system, uncovering the protective potential of ELVs expands the scope of our observations beyond the lung. Our results provide a foundation for interventions to modify disease risk, progression, and protection of the lung from Covid-19 or other pathologies (including some types of pneumonia)," added Dr Bazan.

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New research finds compound that blocks Covid-19 virus and protects lung cells - Hindustan Times

OhioHealth debuts first of its kind Neuroscience Wellness Center – NBC4 WCMH-TV

COLUMBUS, Ohio (WCMH) OhioHealth calls its new 18,000 square foot building just north of Riverside Methodist Hospital the first of its kind facility in the country. Tuesday, the hospital system unveiled the Neuroscience Wellness Center during a grand opening celebration.

What weve never done before is had a space where we could do all-access membership, explained Lauren Esposito, a physical therapist, and the manager of the new center.

The freestanding center will serve as a central location with amenities for people living with the effects of strokes, Parkinsons disease, multiple sclerosis, and other neurological conditions. Esposito gave NBC4 a tour of the facility Tuesday and highlighted the buildings indoor track, four education studios, several open gyms, and group fitness class areas.

Much of the exercise equipment can be adapted for use with wheelchairs or harnesses and can be operated by individuals with limited motor skills.

Every client space has a view of the trees outside. Access to a central courtyard, community garden, and outdoor yoga deck give the facility the appearance of a nature retreat.

This is a unique environment where they can come in and they have the courses, the exercise, the yoga, the mindfulness, the wellness, said Dr. Brien Smith, the Vice President of OhioHealth Neuroscience.

Part of what makes the center unique, Dr. Smith explained, is the sense of community it fosters. Caregivers will be able to use the facility along with patients and seating areas to encourage members to relax and spend time with one another.

We found that our members were really making a lot of connections with each other, Esposito said. And we wanted to create a space where they could gather and talk and really build those bonds.

She explained the wellness center will help patients build healthy lifestyles as they transition out of physical therapy. OhioHealths medical teams were consulted when creating the space and exercise physiologists will offer advice to members.

Non-members will have access to free classes at the facility and will be able to watch recorded videos of the seminars.

The Neuroscience Wellness Center was funded by $12.6 million in donations.

If youre interested in becoming a member, you can schedule and learn more by visiting OhioHealth.com/NeuroscienceWellnessCenter and completing a membership form.

You can also email NWCmembership@ohiohealth.com or call 614-788-5660 for more information.

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OhioHealth debuts first of its kind Neuroscience Wellness Center - NBC4 WCMH-TV

What Does Neuroscience Have To Do With Exercise? A Lot According To Cyborggainz: A New Way Of Thinking About Well Rounded Fitness – Yahoo Finance

Bloomberg

(Bloomberg) -- It was past 9 p.m. on Financial Street in Beijing by the time the figure inside Huarong Tower there picked up an inkbrush and, with practiced strokes, began to set characters to paper.Another trying workday was ending for Wang Zhanfeng, corporate chairman, Chinese Communist Party functionaryand, less happily, replacement for a man who very recently had been executed.On this April night, Wang was spotted unwinding as he often does in his office: practicing the art of Chinese calligraphy, a form that expresses the beauty of classical characters and, it is said, the nature of the person who writes them.Its mastery requires patience, resolve, skill, calmand Wang, 54, needs all that and more. Because here on Financial Street, a brisk walk from the hulking headquarters of the Peoples Bank of China, a dark drama is playing out behind the mirrored faade of Huarong Tower. How it unfolds will test Chinas vast, debt-ridden financial system, the technocrats working to fix it, and the foreign banks and investors caught in the middle.Welcome to the headquarters of China Huarong Asset Management Co., the troubled state-owned bad bank that has set teeth on edge around the financial world.For months now Wang and others have been trying to clean up the mess here at Huarong, an institution that sitsquite literallyat the center of Chinas financial power structure. To the south is the central bank, steward of the worlds second-largest economy; to the southwest, the Ministry of Finance, Huarongs principal shareholder; less than 300 meters to the west, the China Banking and Insurance Regulatory Commission, entrusted with safeguarding the financial system and, of late, ensuring Huarong has a funding backstop from state-owned banks until at least August.The patch though doesnt settle the question of how Huarong makes good on some $41 billion borrowed on the bond markets, most incurred under Wangs predecessor before he was ensnared in a sweeping crackdown on corruption. That long-time executive, Lai Xiaomin, was put to death in Januaryhis formal presence expunged from Huarong right down to the signature on its stock certificates.The bigger issue is what all this might portend for the nations financial system and efforts by Chinas leader, Xi Jinping, to centralize control, rein in years of risky borrowing and set the nations financial house in order.Theyre damned if they do and damned if they dont, said Michael Pettis, a Beijing-based professor of finance at Peking University and author of Avoiding the Fall: Chinas Economic Restructuring. Bailing out Huarong would reinforce the behavior of investors who ignore risk, he said, while a default endangers financial stability if a chaotic repricing of the bond market ensues.Just what is going on inside Huarong Tower? Given the stakes, few are willing to discuss that question publicly. But interviews with people who work there, as well as at various Chinese regulators, provide a glimpse into the eye of this storm.Huarong, simply put, has been in full crisis mode ever since it delayed its 2020 earnings results, eroding investor confidence. Executives have come to expect to be summoned by government authorities at a moments notice whenever market sentiment sours and the price of Huarong debt sinks anew. Wang and his team must provide weekly written updates on Huarongs operations and liquidity. They have turned to state-owned banks, pleading for support, and reached out to bond traders to try to calm nerves, with little lasting success.In public statements, Huarong has insisted repeatedly that its position is ultimately sound and that it will honor its obligations. Banking regulators have had to sign off on the wording of those statementsanother sign of how serious the situation is considered and, ultimately, whos in charge.Then there are regular audiences with the finance ministry and the other powerful financial bureaucracies nearby. Among items usually on the agenda: possible plans to hive off various Huarong businesses.Huarong executives are often kept waiting and, people familiar with the meetings say, tend to gain only limited access to top officials at the CBIRC, the banking overseer.The countrys apex financial watchdogchaired by Liu He, Xis right-hand man in overseeing the economy and financial systemhas asked for briefings on the Huarong situation and coordinated meetings between regulators, according to regulatory officials. But it has yet to communicate to them a long-term solution, including whether to impose losses on bondholders, the officials said.Representatives at the Peoples Bank of China, the CBIRC, Huarong and the Ministry of Finance didnt respond to requests for comment.Focus on BasicsA mid-level party functionary with a PhD in finance from Chinas reputed Southwestern University of Finance and Economics, Wang arrived at Huarong Tower in early 2018, just as the corruption scandal was consuming the giant asset management company. He is regarded inside Huarong as low-key and down-to-earth, particularly in comparison to the companys previous leader, Lai, a man once known as the God of Wealth.Hundreds of Huarong staff, from Beijing division chiefs to branch employees in faraway outposts, listened in on April 16 as Wang reviewed the quarterly numbers. He stressed that the companys fundamentals had improved since he took over, a view shared by some analysts though insufficient to pacify investors. But he had little to say about what is on so many minds: plans to restructure and shore up the giant company, which hed pledged to clean up within three years of taking over.His main message to the troops: focus on the basics, like collecting on iffy assets and improving risk management. The employees were silent. No one asked a question.One employee characterized the mood in his area as business as usual. Another said co-workers at a Huarong subsidiary were worried the company might not be able to pay their salaries. Theres a widening gulf between the old guard and new, said a third staffer. Those who outlasted Lai and have seen their compensation cut year after year have little confidence in the turnaround, while new joiners are more hopeful about the opportunities the change of direction offers.Others joke that Huarong Tower must suffer from bad feng shui: after Lai was arrested, a bank that had a branch in the building had to be bailed out to the tune of $14 billion.Dark humor aside, a rough consensus has begun to emerge among senior management and mid-level regulators: like other key state-owned enterprises, Huarong still appears to be considered too big to fail. Many have come away with the impressionand it is that, an impressionthat for now, at least, the Chinese government will stand behind Huarong.At the very least, these people say, no serious financial tumult, such as a default by Huarong, is likely to be permitted while the Chinese Communist Party is planning a nationwide spectacle to celebrate the 100th anniversary of its founding on July 1. Those festivities will give Xiwho has been positioning to stay in power indefinitelyan opportunity to cement his place among Chinas most powerful leaders including Mao Zedong and Deng Xiaoping.Huarong is nowhere near defaulting, the managing editor of Caixin Media wrote in an opinion piece on Saturday. Neither the Ministry of Finance nor Chinese regulators would allow it, Ling Huawei wrote.What will come after that patriotic outpouring on July 1 is uncertain, even to many inside Huarong Tower. Liu He, Chinas vice premier and chair of the powerful Financial Stability and Development Committee, appears in no hurry to force a difficult solution. Silence from Beijing has started to rattle local debt investors, who until about a week ago had seemed unmoved by the sell-off in Huarongs offshore bonds.Competing InterestsHuarongs role in absorbing and disposing of lenders soured debt is worth preserving to support the banking sector cleanup, but requires government intervention, according to Dinny McMahon, an economic analyst for Beijing-based consultancy Trivium China and author of Chinas Great Wall of Debt.We anticipate that foreign bondholders will be required to take a haircut, but it will be relatively small, he said. It will be designed to signal that investors should not assume government backing translates into carte blanche support.For now, in the absence of direct orders from the top, Huarong has been caught in the middle of the competing interests among various state-owned enterprises and government bureaucracies.China Investment Corp., the $1 trillion sovereign fund, for instance, has turned down the idea of taking a controlling stake from the finance ministry. CIC officials have argued they dont have the bandwidth or capability to fix Huarongs problems, according to people familiar with the matter.The Peoples Bank of China, meantime, is still trying to decide whether to proceed with a proposal that would see it assume more than 100 billion yuan ($15.5 billion) of bad assets from Huarong, those people said.And the Ministry of Finance, which owns 57% of Huarong on behalf of the Chinese government, hasnt committed to recapitalizing the company, though it hasnt ruled it out, either, one person said.CIC didnt respond to requests for comment.The banking regulator has bought Huarong some time, brokering an agreement with state-owned lenders including Industrial & Commercial Bank of China Ltd. that would cover any funding needed to repay the equivalent of $2.5 billion coming due by the end of August. By then, the company aims to have completed its 2020 financial statements after spooking investors by missing deadlines in March and April.How China deals with Huarong will have wide ramifications on global investors perception of and confidence in Chinese SOEs, said Wu Qiong, a Hong Kong-based executive director at BOC International Holdings. Should any defaults trigger a reassessment of the level of government support assumed in rating SOE credits, it would have deep repercussions for the offshore market.The announcement of a new addition to Wangs team underscores the stakes and, to some insiders, provides a measure of hope. Liang Qiang is a standing member of the All-China Financial Youth Federation, widely seen as a pipeline to groom future leaders for financial SOEs. Liang, who arrived at Huarong last week and will soon take on the role of president, has worked for the three other big state asset managers that were established, like Huarong, to help clean up bad debts at the nations banks. Some speculate this points to a wider plan: that Huarong might be used as a blueprint for how authorities approach these other sprawling, debt-ridden institutions.Meantime, inside Huarong Tower, a key item remains fixed in the busy schedules of top executives and rank-and-file employees alike. It is a monthly meeting, the topic of which is considered vital to Huarongs rebirth: studying the doctrines of the Chinese Communist Party and speeches of President Xi Jinping. (Updates to mention Caixin managing editors opinion piece on the matter. )More stories like this are available on bloomberg.comSubscribe now to stay ahead with the most trusted business news source.2021 Bloomberg L.P.

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What Does Neuroscience Have To Do With Exercise? A Lot According To Cyborggainz: A New Way Of Thinking About Well Rounded Fitness - Yahoo Finance

Mice licking could reveal mysteries of the human brain | Cornell Chronicle – Cornell Chronicle

Every time we reach for a cup, our brains must assess our hands current position in relation to the mug and then command muscles to make the proper adjustments to successfully grab the handle.

The neuroscience of reaching for something and making on-the-spot adjustments has been studied for a century in monkeys.

But now, for the first time, Cornell researchers have developed a technique for studying such motor control in mice by focusing on a mouses tongue when it licks a water spout.

The technique incorporates high-speed cameras and machine learning in a tractable experimental setup that opens the door for revealing mysteries of how the motor cortex works, understanding the neural basis of related disorders like Parkinsons disease, and informing robotics.

We now have an approach in a mouse where we can bring all the tools of modern neuroscience to bear on this really classic problem of motor control, said Jesse Goldberg, associate professor and Robert R. Capranica Fellow in the Department of Neurobiology and Behavior in the College of Arts and Sciences (A&S).

Goldberg is senior author of the paper, Cortex-dependent corrections as the tongue reaches for, and misses, targets, published May 19 in Nature. Tejapratap Bollu, Ph.D. 20, a former graduate student in Goldbergs lab and currently a postdoctoral researcher at the Salk Institute, and Brendan Ito, a graduate student in the Department of Neurobiology and Behavior, are the papers co-first authors.

The field of motor control neuroscience has made advancements almost entirely through studies of monkeys reaching for things, Goldberg said. His lab tried for years to develop a mouse model for much faster and more malleable experiments, but found too many constraints in getting mice to reach with their limbs; mice lack the necessary biomechanics and nature for such movements.

Bollu, who was working on a different project that involved mice licking a water spout, made a discovery that led to the new technique. The water spouts were fitted with contact sensors, but often, the tongue would miss the target.

Bollu noticed with his careful eyes that [the mice] were actually sticking their tongues out and looking for the spout, rather than licking as had been assumed, Goldberg said. The movement in mice, which occurs on time scales of close to 100 milliseconds per lick, is analogous to a monkey reaching and making adjustments with its hand, and activates the motor cortex in a surprisingly similar manner, the researchers found.

During a casual conversation between Bollu and co-author Sam Whitehead, a graduate student in the lab of Itai Cohen, professor of physics in A&S, Whitehead suggested they use high-speed cameras to better observe the movements of the mouse tongues. Then, undergraduate co-author James Redd 18 helped devise an artificial neural network to sift through terabytes of data from millions of image frames to isolate and track the tongue.

With their system in place, the researchers could observe the tongue reaching for the water spout, just as a human reaches for an object. They could also move the water spout, which forced a miss and an immediate correction. At the same time, genetically engineered mice allowed the researchers to use light to turn different parts of the brain on and off while the animals were drinking.

They inactivated the part of the brain, the anterolateral motor cortex, known to be important for online corrections when a primate reaches.

We observed that the mice could still lick when they could not make these online corrections, but they missed the spout, Goldberg said. That part of the brain was not required to generate a lick, but it was required to contact the spout.

The researchers were able to use brain activation experiments to zoom in on the anterolateral motor cortex. The electrical signals there exhibited remarkable similarity to the types of electrical signals people observed in primate reach tasks, Goldberg said.

Now we can do experiments that have never been done before, he said.

Cornell Neurotech has developed technologies that make it possible to record thousands of neurons in an animal at once, for example. In next steps, Goldberg plans to use these tools to characterize for the first time the origins of pathogenic brain signals in neurological disorders, such as Parkinsons disease.

The study was funded by the National Institutes of Health, the Dystonia Medical Research Foundation, the Pew Charitable Trust, Jean Sheng '77, Kent Sheng '78, the Klingenstein Neuroscience Foundation and the National Science Foundation.

Continued here:
Mice licking could reveal mysteries of the human brain | Cornell Chronicle - Cornell Chronicle

Anesthesia Doesn’t Simply Turn Off the Brain It Dramatically Changes and Controls Its Rhythms – SciTechDaily

Researchers measured how strongly brain waves were synchronized before, during, and after anesthesia with propofol. Data from the research shows strong increases in synchrony only in very slow frequencies (deep red color along bottom) between the thalamus and four cortical regions while animals were unconscious. Credit: Image courtesy of the Miller/Brown labs, Picower Institute

Simultaneous measurement of neural rhythms and spikes across five brain areas reveals how propofol induces unconsciousness.

In a uniquely deep and detailed look at how the commonly used anesthetic propofol causes unconsciousness, a collaboration of labs at the Picower Institute for Learning and Memory at MIT shows that as the drug takes hold in the brain, a wide swath of regions become coordinated by very slow rhythms that maintain a commensurately languid pace of neural activity. Electrically stimulating a deeper region, the thalamus, restores synchrony of the brains normal higher frequency rhythms and activity levels, waking the brain back up and restoring arousal.

Theres a folk psychology or tacit assumption that what anesthesia does is simply turn off the brain, says Earl Miller, Picower Professor of Neuroscience and co-senior author of the study in eLife. What we show is that propofol dramatically changes and controls the dynamics of the brains rhythms.

Conscious functions, such as perception and cognition, depend on coordinated brain communication, in particular between the thalamus and the brains surface regions, or cortex, in a variety of frequency bands ranging from 4 to 100 hertz. Propofol, the study shows, seems to bring coordination among the thalamus and cortical regions down to frequencies around just 1 hertz.

Millers lab, led by postdoc Andre Bastos and former graduate student Jacob Donoghue, collaborated with that of co-senior author Emery N. Brown, who is the Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience and an anesthesiologist at Massachusetts General Hospital. The collaboration therefore unified the Miller labs expertise on how neural rhythms coordinate the cortex to produce conscious brain function with the Brown labs expertise in the neuroscience of anesthesia and statistical analysis of neural signals.

Brown says studies that show how anesthetics change brain rhythms can directly improve patient safety because these rhythms are readily visible on the EEG in the operating room. The studys main finding of a signature of very slow rhythms across the cortex offers a model for directly measuring when subjects have entered unconsciousness after propofol administration, how deeply they are being maintained in that state, and how quickly they may wake up once propofol dosing ends.

Anesthesiologists can use this as a way to better take care of patients, Brown says.

Brown has long studied how brain rhythms are affected in humans under general anesthesia by making and analyzing measurements of rhythms using scalp EEG electrodes and, to a limited extent, cortical electrodes in epilepsy patients. Because the new study was conducted in animal models of those dynamics, the team was able to implant electrodes that could directly measure the activity or spiking of many individual neurons and rhythms in the cortex and thalamus. Brown said the results therefore significantly deepen and extend his findings in people.

For instance, the same neurons that they measured chattering away with spikes of voltage 7-10 times a second during wakefulness routinely fired only once a second or less during propofol-induced unconsciousness, a notable slowing called a down state. In all, the scientists made detailed simultaneous measurements of rhythms and spikes in five regions: two in the front of the cortex, two toward the back, and the thalamus.

Whats so compelling is we are getting data down to the level of spikes, Brown says. The slow oscillations modulate the spiking activity across large parts of the cortex.

As much as the study explains how propofol generates unconsciousness, it also helps to explain the unified experience of consciousness, Miller says.

All the cortex has to be on the same page to produce consciousness, Miller says. One theory about how this works is through thalamo-cortical loops that allow the cortex to synchronize. Propofol may be breaking the normal operation of those loops by hyper synchronizing them in prolonged down states. It disrupts the ability of the cortex to communicate.

For instance, by making measurements in distinct layers of the cortex, the team found that higher-frequency gamma rhythms, which are normally associated with new sensory information like sights and sounds, were especially reduced in superficial layers. Lower-frequency alpha and beta waves, which Miller has shown tend to regulate the processing of the information carried by gamma rhythms, were especially reduced in deeper layers.

In addition to the prevailing synchrony at very slow frequencies, the team noted other signatures of unconsciousness in the data. As Brown and others have observed in humans before, alpha and beta rhythm power was notably higher in posterior regions of the cortex during wakefulness, but after loss of consciousness power at those rhythms flipped to being much higher in anterior regions.

The team further showed that stimulating the thalamus with a high-frequency pulse of current (180 hertz) undid propofols effects.

Stimulation produced an awake-like cortical state by increasing spiking rates and decreasing slow-frequency power, the authors wrote in the study. In all areas, there was a significant increase in spiking during the stimulation interval compared to pre-stimulation baseline.

Reference: Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation by Andr M Bastos, Jacob A Donoghue, Scott L Brincat, Meredith Mahnke, Jorge Yanar, Josefina Correa, Ayan S Waite, Mikael Lundqvist, Jefferson Roy, Emery N Brown and Earl K Miller, 27 April 2021, eLife.DOI: 10.7554/eLife.60824

In addition to Miller, Brown, Bastos and Donoghue, the papers other authors are Scott Brincat, Meredith Mahnke, Jorge Yanar, Josefina Correa, Ayan Waite, Mikael Lundqvist, and Jefferson Roy.

The National Institutes of Health and the JPB Foundation provided funding for the study.

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Anesthesia Doesn't Simply Turn Off the Brain It Dramatically Changes and Controls Its Rhythms - SciTechDaily