Category Archives: Neuroscience

Neuroscience: How music meets mind – Nature.com

Adam Ockelford Profile: 2017. ISBN: 9781781256039

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Whether tapping a foot to samba or weeping at a ballad, the human response to music seems almost instinctual. Yet few can articulate how music works. How do strings of sounds trigger emotion, inspire ideas, even define identities?

Cognitive scientists, anthropologists, biologists and musicologists have all taken a crack at that question (see go.nature.com/2sdpcb5), and it is into this line that Adam Ockelford steps. Comparing Notes draws on his experience as a composer, pianist, music researcher and, most notably, a music educator working for decades with children who have visual impairments or are on the autistic spectrum, many with extraordinary musical abilities. Through this prism of the overtly remarkable, Ockelford seeks to shed light on music perception and cognition in all of us. Existing models based on neurotypical children could overlook larger truths about the human capacity to learn and make sense of music he contends.

George Pickow/Three Lions/Getty

How the human brain processes music remains a mystery.

Some of the children described in Comparing Notes might (for a range of reasons) have trouble tying their shoelaces or carrying on a basic conversation. Yet before they hit double digits in age, they can hear a complex composition for the first time and immediately play it on the piano, their fingers flying to the correct notes. This skill, Ockelford reminds us, eludes many adults with whom he studied at London's Royal Academy of Music. Weaving together the strands that let these children perform such stunning feats, Ockelford constructs an argument for rethinking conventional wisdom on music education.

He positions absolute pitch (AP) as central to these abilities to improvise, listen and play. Only 1 in 10,000 neurotypical people in the West have AP the ability to effortlessly, without context, name the note sounded by a violin or a vacuum cleaner (That's an F-sharp!). Among those on the autism spectrum, the number rises to 8%, roughly 1 in 13. For people born blind or who lost their sight early in infancy, it is 45%. AP, Ockelford argues, enables children to sound out and tinker with familiar tunes; that experimentation leads to a deep grasp of musical structure.

Many of the children Ockelford works with were born blind and autistic. For them, the predictability of the keyboard experienced through the lens of AP can trigger obsessive fascination. The US television programme 60 Minutes featured footage of musical savant Rex Lewis-Clack as a toddler: as he falls asleep next to a keyboard, we see his hand drowsily reaching out to play two last notes before he drifts off. Children with this kind of passion can spend hundreds of hours at the keyboard, mapping sound to movement.

An experiment with Derek Paravicini one of Ockelford's most accomplished students, now an adult supports the idea that AP underlies a sense of musical structure rather than being solely responsible for remarkable performances. Ockelford asked Paravicini to play back two versions of the same piece: one flouting the conventional rules of Western harmony, the other following them. Paravicini's performance of the second was much more accurate. This suggests that he relies on intuition about structures typical to Western music, to which he was exposed during some crucial period of brain plasticity.

Ockelford devotes much of Comparing Notes to an entertaining but idiosyncratic romp through music theory and psychology, including his own zygonic theory. This holds that repetition and transformation of musical elements can be perceived as intentional imitation an insight born in improvisation games with his students. Although few would argue with its central tenet, zygonic theory has not gained much traction, partly because its complex notation does not seem to produce insights different from those of simpler tools. In one diagram, an arrow between two identical notes shows that repetition leads to a sense of imitation and derivation surely better conveyed in a sentence. The increasingly intricate diagrams do not seem to communicate more than basic concepts such as transposition (the repetition of a pattern of notes at a different pitch level).

Ockelford also misses opportunities to develop his ideas about how structure and repetition work. In comparing music and language, he refers only once to Aniruddh Patel's influential Music, Language, and the Brain (Oxford University Press, 2008), which explores this terrain. He never mentions Diana Deutsch's speech-to-song illusion, a demonstration of how repetition can transform a spoken phrase into a perceived song (D. Deutsch J. Acoustical Soc. Am. 124, 2471; 2008), or my 2014 On Repeat (Oxford University Press), which takes a psychological approach to understanding how repetition in music 'plays' the mind.

Many examples in Comparing Notes rely on the ability to read music, yet the book elucidates topics (such as the definition of a scale) that most people able to follow the examples would already understand. Thus, the target audience seems hazy. For a fuller understanding of how music works, I recommend consulting an overview from musicology, such as Mark Evan Bonds' Listen to This (Prentice Hall, 2008), and one from psychology, such as Daniel Levitin's This is Your Brain on Music (Dutton Penguin, 2006). Ockelford's perceptive chronicle of his experiences with extraordinary music makers reminds us, however, that this puzzle is one that we need to keep probing.

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Neuroscience: How music meets mind - Nature.com

Springer purge of fake reviews takes down 10+ more neuroscience papers – Retraction Watch (blog)

Back in April, Springer retracted a record number 107 papers from Tumor Biology after uncovering evidence they were subject to fake peer reviews. But it appears that the Tumor Biologysweep was only part of the story.

During the Tumor Biology investigation, Springer found evidence that the peer review process was compromised in a dozen papers on brain cancer published in another journal. The 12 Molecular Neurobiologyretractions have trickled in over the past year or so, published before and after the Tumor Biology sweep.

A spokesperson at Springer confirmed that the 12 retracted papers in Molecular Neurobiology were related to the TumorBiologyretractions for fake peer review:

The articles came to our attention during the thorough investigation of Tumor Biology articles.

The Springer spokesperson added:

Springer holds itself to the highest standards when it comes to identifying and solving research integrity and peer review issues and will continue to proactively investigate these issues.

We reported on one of these Molecular Neurobiology retractions back in May 2016. However, thenotice for the 2014 paper didnt mention problems with peer review only that the authors admitted they used material in the paper that did not originate from their lab.

Since then, we have received word from frequent tipster Rolf Degen of several other retractions in Molecular Neurobiology, which have mentioned evidence of faked reviews. The Springer spokesperson confirmed that 12 recently retracted papers including the one wed already reported on were tied to the larger investigation. This brings the total number of papers retracted over fake reviews to more than 500.

Thesedozen retracted papers in Molecular Neurobiologyhave many authors in common. All of the authors are based at universities and hospitals in China, such as Guangzhou Medical University and Affiliated Hospital of Shandong Academy of Medical Sciences, and some are also listed as authors on the retracted Tumor Biology papers. Weve reached out to 10of the corresponding authors for whom we could find contact information, but have not heard back.

Heres one of the notices for a 2015 paper retracted over suspicion of compromised peer review and other issues:

This article has been retracted at the request of the Editor-in-Chief and the Publisher. The article shows evidence of irregularities in authorship during the submission process. There is strong reason to believe that the peer review process was compromised and the authors have plagiarized parts from the following article:

Shunzeng Lv, Ekaterina Turlova, Shigang Zhao, Huihui Kang, Mingzhi Han, Hong-Shuo Sun, Prognostics and clinicopathological significance of survivin expression in bladder cancer patients: a meta-analysis. Tumor Biol. (2014) 35: 1565. doi:10.1007/s13277-013-1216-y; Received: 23 July 2013

In addition, the article shows similarities with the following article which was submitted within a close timeframe:

Xiangshan Yang, Shunzeng Lv, Yuting Liu, Daotang Li, Ranran Shi, Zhenyu Tang, Jianzhen Fan, Zhongfa Xu, The Clinical Utility of Matrix Metalloproteinase 9 in Evaluating Pathological Grade and Prognosis of Glioma Patients: A Meta-Analysis. Mol Neurobiol (2015) 52: 38. doi:10.1007/s12035-014-8850-2; Received: 20 July 2014

The article The impact of survivin on prognosis and clinicopathology of glioma patients: a systematic meta-analysis was received on 26 June 2014.

As such the validity of the content of this article cannot be verified.

The 2015 paper, The Impact of Survivin on Prognosis and Clinicopathology of Glioma Patients: A Systematic Meta-Analysis, was retracted online in January 2017, and has been cited five times, according to Clarivate Analytics Web of Science.

Heres the list of the 11 other retractions, including the one we covered last year. All notices mention suspicions of problems with peer review, and some also suggest issues with authorship and/or plagiarism:

In February, after we first learned of some of these retractions (and before the Tumor Biology sweep), aSpringer spokesperson told us:

The authors submitted the papers within a narrow timeframe. Since these were submitted papers, and not published papers, a standard plagiarism detection software did not identify them. Only after publication were the similarities spotted.

When Springer contacted the authors, some apologized, while others gave information about third parties helping them out, the spokesperson said. She added:

Springer Nature is currently working on some improvement processes. With respect to authorship, we have started the implementation of a new functionality which will automatically flag changes in the author list between paper revisions. We are also working on a project to verify the identity of individuals invited to peer reviewer a paper. Credentials from peer reviewers will be checked through an automated process, for example, by confirming an institutional e-mail address. Concerning manuscripts, Springer Nature is rolling out a manuscript screening service within a new improved workflow.

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Springer purge of fake reviews takes down 10+ more neuroscience papers - Retraction Watch (blog)

Neuroscience Tells Us How to Hack Our Brains for Success – Entrepreneur

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Whats the secret to success? Some would argue that insanely successful peoplepossess traitslike having a vision, showing gratitude, being honest, learning from failureand having a high emotional intelligence.

While these traits definitely play a role, the real secret to success comes down to science,particularly advancements in neuroscience, and how you can condition your brain to achieve your dreams and goals.

The neuroscience of success can get complicated, but its really about how your brain functions in three different areas:reticular activating system (RAS), the release of dopamineand your memory. If youre not a science person, Ill try and make this all as painless as possible.

Related:How to Hack Your Brain Chemicals to Be More Productive

Located at the base of the brain where it connects with the spinal cord, theres one of most important parts of the brain:thereticular activating system.

RAS influences cognition and is basically a filter for the roughly eight million bits of information (subconsciously) flowing through our brain. In other words, it eliminates the white noise. When a message gets past the RAS filter it enters the cerebrum and is then converted into conscious thoughts, emotionsor even both.

As Ruben Gonzalez, author ofThe Courage to Succeed,explains, Even though the cerebrum is the center of thought, it will not respond to a message unless the RAS allows it. The RAS is like Google. There are millions of websites out there, but you filter out the ones you are not interested in simply by typing a keyword.

So, what messages get through? Pretty much just the ones that are currently important to you. For example, if youre focused on preparing for a speaking engagement then your RAS is going to filter in the thoughts that are going to make your presentation a success, such as the tools and resources youll need to deliver a memorable speech.

As Gonzalez adds, This means the more you keep your goals top of mind, the more your subconscious mind will work to reach them. Thats why writing your goals down every day, visualizing your intended outcome and regularly saying affirmations is so important! Doing those things truly does help you to focus your subconscious mind on whats important to you.

Related:The Extraordinary Power ofVisualizingSuccess

While RAS can help you focus on the desired outcome youd like to receive, the release of dopamine is what makes success feel oh-so-good.

As Mark Lukens, founding partner of Method3, wrote recently, When we succeed at something, our brains release chemical rewards, the most important of which is the neurotransmitter dopamine, a chemical best known for the role it plays in addiction and drug use. Dopamine, despite this negative association, is a natural part of how our brains function, producing the sensation of pleasure whenever you taste coffee or chocolate, or when you achieve a big win.

Because of this, it makes sense that dopamine is strongly connected to motivation, driving us to repeat the behaviors that create that rush, even when we arent experiencing it. However, the dopamine response is short-term, but since our brains remember how awesome it was before, we strive to seek it out over and over again.

Thats when dopamine loops enter the picture.After youve experienced repeated success the pleasure you initially had gets smaller and smaller. Think of it this way:After youve already beaten a video game, it just doesnt feel as good the second or third time, right? Thats when you seekbigger rewards, like unlocking trophies, new charactersor swag when completing a level.

Under the right circumstances, this can drive us to seek out ever-greater thrills, adds Lukens. Its why video game players are constantly engaged, its the reason why you check your phone every minute after updating your Facebook status, and its what motivates us in accomplishing bigger and better things.

For instance, if your goal was to acquire three new clients within two weeks, then yournext goal would be to acquire six new clients in one week. Everything else is the same, except the more challenging, and rewarding, task of doubling your stable of clients.As an added perk, this also helps you weed out the work and goals that arent motivating you or your team.

Related:Trigger These 4 Key Brain Chemicals for Happier Workers

Neuroscientists who have studied the way that thebrain retrieves memoriescan also determine success.

Think about that for a second. That time you went mountain biking and had a nasty spill? That was a bad experience that might discourage you from mountain biking again, at least for the foreseeable future. The same is true with starting a business.It failedand now you are more hesitant about taking that risk again.

Scientists, however, found that we can edit those bad memories to remove the negative associations. In fact, this memory therapy is used to treat PTSD sufferers. You can also edit good memories to further propel youtowards success.

To weaken bad memories, bring that memory back and then let it get smaller and dimmer, like youre watching a small black-and-white TV fade out. Once there, insert new details that scramble the memory. For instance, think about the time you bombed while giving a speech or investor pitch. Now just imagine that your audience was dressed in something that made you laugh. Do that five or 10 times and that memory will make you chuckle.

As for strengthening your memories, recall the good memories as bright and loud as possible, like watching a movie in an IMAX theater. Keepadding how that experience made you feel for five or 10 times. You should now feel on-top-of-the-world. Use that to motivate you going forward.

Related:How to Be Grateful When Times Are Tough

The good news is that you can actually rewire your brain to become more successful. In fact,according to neuroscientist Michael Merzenich, it takes just 30 hours of training based on specific neuroscience techniques to improve your memory and cognition, speech patternsand reading comprehension.

I know. That may sound like a lot. But, thats just an hour a day for a month to achieve life-long success. I think thats totally worth it. And, most of this training involves simple daily tasks, like:

John Rampton is an entrepreneur, investor, online marketing guru and startup enthusiast. He is founder of the online invoicing company Due. John is best known as an entrepreneur and connector. He was recently named #3 on Top 50 Online Influ...

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Neuroscience Tells Us How to Hack Our Brains for Success - Entrepreneur

Noninvasive Deep Brain Stimulation – Has Neuroscience’s Holy … – Discover Magazine (blog)

A high-profile paper in Cell reports on a new brain stimulation method thats got many neuroscientists excited. The new technique,called temporal interference (TI) stimulation, is said to be able to reach structures deep inside the brain, using nothing more than scalp electrodes.

Currently, the only way to stimulate deep brain structures is by implanting electrodes (wires) into the brain which is an expensive and potentially dangerous surgical procedure. TI promises to make deep brain stimulation an everyday, non-invasive tool. But will it really work?

The paper comes fromNir Grossman et al. from the lab of Edward S. Boyden at MIT. Their technique is based around applying two electrical fields to the subjects head. Each field is applied using two scalp electrodes.

It is the interaction between the two fields that creates brain stimulation. Both fields oscillate at slightly different frequencies, for instance 2 kHz and 2.01 kHz. Where these fields overlap, a pattern of interference is created which oscillates with an envelope at a much lower frequency, say 10 Hz. The frequency of the two fields is too high to have any effect on neural activity, but the interference pattern does have an effect.

Crucially, while the electric fields are strongest close to the electrodes, the interference pattern is most intense at a remote point which could be deep in the brain. Heres an overview:

Grossman et al. present a lot of evidence validating the TI concept and showing that it does allow selective, deep-brain stimulation in mouse brains. The most striking data comes from an experiment in which Grossman et al. used TI to stimulate the hippocampus of mice without stimulating the cerebral cortex. This is remarkable because the hippocampus is deep in the brain, and far from the electrodes:

Whats more, TI stimulation is steerable. By varying the strength of the two electrical fields, Grossman et al. were able to move the stimulation zone. This holds out the exciting possibility that neuroscientists could easily stimulate different brain regions, without having to implant an electrode in each one.

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Theres no doubt that this is one of the most exciting neuroscience papers to come along in a long time. Its a clich, but TI really could revolutionize neuroscience, as well as having clinical applications in the treatment of disorders such as Parkinsons disease and more.

But will it work in humans? Grossman et al. imply that it will:

We anticipate that it might rapidly be deployable into human clinical trials, as well as studies of the human brain.

Grossman et al. seem so confident about the human applications of TI, they used a human brain in their graphical abstract (reproduced above) even though only mouse brains appear in the paper.

Theres one obvious snag though: scale. The human brain is much bigger than the mouse brain. When Grossman et al. achieved deep stimulation of the mouse hippocampus, the hippocampus was about 3 millimeters away from the electrodes. In humans, the depth would be about ten times as high.

Presumably, it would be possible to compensate for the increased distances by using stronger electrical fields in humans, but this might create safety issues. Boyden and his group are reportedly working on human studies at the moment.

Another problem with TI could be that the stimulation zone wont have clean edges: brain areas close to the stimulation target may get some degree of stimulation too. This would be undesirable, although its not necessarily a fatal problem, and optimization of the electrode placement could help to sharpen the stimulation zone.

Finally: how new is the idea of TI? Grossman et al. dont cite any previous literature on the method. This lead me to assume, when I read the paper, that the idea of deep stimulation via two interfering electrical fields was a new one.

However, I learned on Twitter that its not a new concept. Interferential Stimulation (IS) was reportedly first proposed by Soviet scientists as early as 1965, and has since become an established tool in electrotherapy, i.e. the use of electrical stimulation on the nerves to treat pain. Heres a 1996 patent (one of many) for an Interferential stimulator for applying localized electrotherapy stimulation.

As far as I can see, Grossman et al. are the first people to use interferential stimulation in the brain, but they didnt originate the technique itself.

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Noninvasive Deep Brain Stimulation - Has Neuroscience's Holy ... - Discover Magazine (blog)

UCL Neuroscience Symposium – Epilepsy Research UK

Today Friday 16th we have been at the annual UCL (University College London) Neuroscience Symposium. It is immenselypopular and attracts almost around 800 delegates. Epilepsy Research UK projects were in evidence and I had the opportunity to meet some of our current researchers as well as young researchers that we would like to encourage in order to keep their skills in the field of epilepsy.

You can find more details of the UCL Symposium and download the abstract booklet here.

Dr Stephanie Schorge explains her research to an interested symposium delegate.

Dr Gabriele Lignani Epilepsy Research UK Fellowship holder with details of his preliminary findings.

Among the Epilepsy Research UK funded researchers was Dr Stephanie Schorge who was presenting some details of her work on gene therapy and refractory epilepsy. We also met Dr Gabriele Lignani who has just been awarded an Epilepsy Research UK Fellowship. Dr Ligani was presenting his work on how to increase promoter activity to treat intractable epilepsy. We also ran into Albert Snowball from the UCL Institute of Neurology who was presenting his work on gene therapy for epilepsy using non-integrating lentiviral delivery of an engineered potassium channel gene. The Institute of Neurology at UCL has a worldwide reputation and as an organisation, we are proud to help fund some of the fantastic work that is going on there.

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UCL Neuroscience Symposium - Epilepsy Research UK

How Neuroscience Can Help You Become an Intuitive Eater | HuffPost – HuffPost

by Elyse Resch, RDN, CEDRD, nutrition therapist and author of The Intuitive Eating Workbook

I cant count the times that potential clients have said, If you tell me that I can eat whatever I want, Ill never stop eating it! To them, Intuitive Eating means eating whatever you want and as much as you want, whenever you want. But Intuitive Eating is more nuanced than simply making impulsive food decisions.

Intuitive Eating is an autonomous process. As a nutrition therapist, I dont tell my clients what to eat. Instead, I guide my clients through the process of rediscovering their inner wisdom that helps them make decisions about eating. After all, most people are born with all the wisdom they need to know how to eat. Unfortunately, they get distracted from this wisdom along the way and need to be led back to it.

To start that journey back to freedom and safety in eating, its important to understand the neuroscience behind Intuitive Eating. Our brains are the masterminds of our behavior, including eating. The multi-faceted development of the human brain has a lot to do with how we decide what we eat and how much.

Way back in time, when the earth was occupied by dinosaurs, eating was a very different experience than it is today. Dinosaurs had a primitive layer of brain functioning, which we call the reptilian brain. This brain had only one function: to survive. So if a dinosaur saw another dinosaur to prey uponprey it did! The dinosaur went after food in an instinctual way. It didnt have the ability to have any feelings about food. The dinosaur wasnt scared to eat it, the way many people with disordered eating feel when theyre about to eat. Actually, the dinosaur didnt feel anything. It didnt feel scared, excited, or even bored about eating. It simply ate to stay alive.

When animals evolved into mammals, their brains developed another level of brain functioning called the mammalian brain or the limbic brain. This part of the brain is the center of emotions and social functioning. The limbic brain sits upon the primitive matrix of the reptilian brain. Lets say you have a dog. If you leave town for the weekend and leave the dog with a sitter, he might act out. He may hide under the bed, refuse to go near you, or have an accident on the floor. Why is he acting this way? Because he has feelings! He may feel angry, sad, lonely, or even betrayed that you leftprobably because he had no way of knowing whether youd ever return. The limbic brain is the part of the brain that controls emotion. The dog can have these behaviors because he has the capacity to have feelings, but he doesnt have the ability to form thoughts and speak about them.

When humans evolved, a third level of brain functioning emerged called the human brain or the neocortex. This is the center of rational thought, and it sits on top of the mammalian and reptilian parts of our brain. If our partner leaves town, we not only may feel angry, sad, or lonely, we probably will speak up about it. We might also have similar behaviors to the dogwe wouldnt hide under the bed, but we might keep an emotional distance from our partners for a while.

Human brains are the most complex of all species. The human brain has the instinct to survive, the ability to have feelings, and the mechanism to express thoughts and feelings in words. So how does that play into Intuitive Eating? Intuitive Eating is a dynamic interplay of instinct, emotion, and thought. This means that we have the instinct to eat in order to survive. Our survival instinct gives us the messages of hunger, fullness, and what tastes good to us (reptilian brain). We also have emotions that can either make us feel anxious about eating or excited about experiencing all the flavors, aromas, and textures that foods offer (limbic brain). Finally, we have rational thought, which can comfort any emotions we have about eating, override physical or emotional factors that have to do with appetite, and ultimately change our relationship with food and eating, in positive ways (neocortex).

So, how does this neuroscience recontextualize the fear that if youre told that you can eat whatever you want, youll overeat? If youve truly made peace with food and have made all foods emotionally equivalent, you dont experience the feelings of deprivation that come with restricting certain foods. Since you can always eat whatever you like, and since its not as exciting as it once was to eat a food that was forbidden, your free access to foods you love will melt away worries that youll never stop eating. Your instincts will tell you when youre hungry and when youre fulland youll stop eating when youre full. Youll know intuitively what tastes good and notice when the pleasure in it diminishes. Youll also use the rational part of your brain to comfort any lingering fears about eating and to evaluate how your body feels after eating. Trust me, you wont eat the newly liberated food forever!

By practicing Intuitive Eating, all foods will become part of your eating life, even foods you might be forbidding, like French fries or chocolate. Youll be left with a freedom to eat what you crave and what fills you upa feeling many of us have been disconnected from since early childhood. Once youve gotten the hang of Intuitive Eating, you can trust your wise brain to lead you in the right direction.

Elyse Resch, RDN, CEDRD, is a nutrition therapist with a private practice in Beverly Hills, CA, with over thirty-five years of experience, specializing in eating disorders, intuitive eating, and health at every size. She is co-author of The Intuitive Eating Workbook.

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How Neuroscience Can Help You Become an Intuitive Eater | HuffPost - HuffPost

Politics and the Neuroscience of Fear – Patheos – Patheos (blog)

Guest post by my friend Diogo Goncalves

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We are not thinking machines that feel, we are feeling machines that think.~Antnio Damsio

From the fall of the Berlin Wall until recently, it was common sense in developed countries that we should avoid extremes. In the UK, the far left would never take over the Labor party. In the US, the Ku Klax Klan would never rise to power. In France, Marine Le Pen and the National Front would never constitute a threat. If they tried, sensible voters would reject them.

But on the mornings of the 24th June (Brexit) and the 9th November (Trump) of 2016, the situation changed. Many people across the globe from Manchester to New York, from Brussels to Moscow were (and some still are) incredulous that we seem to be shifting toward the extremes and away from common sense. There is a great deal of fear and anxiety around the planet at these developments. Research in neuroscience shows the dangerous effects of these threatening events.

The Neuroscience of Threats

As an example, consider Mary, the daughter of an abusive alcoholic. The strongest memory she retains from her childhood is of never being able to tell whether she loved her father or hated him. Some days she thought that her father loved her, others she would remember his abuse and blame him for all the stress she had to face on a daily basis.

When people like Mary live in a constant state of fear and anxiety, their prefrontal cortex and hippocampus the thinking and memory-forming parts of the brain start shutting down.

Simultaneously, the amygdala the part of the brain responsible for our emotional responses, specifically fear gets bigger. This neurobiological process severely undermines our capacity for reflective decision making, calculated risk taking, and exploratory activity. It also makes us more prone to extreme, simple, and cognitively rigid solutions, and less empathetic to and understanding of views different from our own.

In 2006, psychologists George Bonanno and John Jost studied high-exposure survivors of the 9/11 terrorist attacks. They discovered that most went through a conservative shift. In order to manage the feelings of uncertainty and threat induced by the attacks, they moved away from liberalism towards conservatism. The authors observed that survivors embraced ideologies that provide relatively simple yet cognitively rigid solutions (e.g., good versus evil, black versus white, us versus them, leader versus follower) to problems of security and threat. However, the political shift didnt improve their overall state of mind, measured in terms of mental health symptoms or friendsrelatives ratings of their psychological adjustment.

Trumps Rhetoric of Threats

They are bringing drugs. They are bringing crime. Theyre rapists.

This and other sentences used by Donald Trump fanned the flames of fear and anxiety, by exposing his audience to stimuli the audience found threatening. This helped shift his audience in a more conservative direction.

Moreover, eliciting fear is highly effective for potentially authoritarian leaders to reach power. These leaders depict themselves as the only solution to the fear and anger felt by the increasingly conservative audience.

Living in fear feeds itself through two extensively studied psychological conditions: probability neglect and confirmation bias. The first tells us that when people are emotionally stirred by something they can vividly imagine, such as a terrorist attack, they will fear its outcome even if its highly unlikely a reaction called misfearing. When Donald Trump uses his speeches to talk about immigration in Europe linked it to terror attacks Brussels, Nice, and Paris, and even a non-event terrorist attack in Sweden, he is using these psychological bias to make people fear a very unlikely event (if they used a cold, rational probabilities analysis, they would conclude that the probability of dying in a terrorist attack is almost inexistent).

The second is related to the fact that the more we see something, such as TV depictions of immigrants who bring crime and drugs, the more we pay extra attention to it in the future, over time causing us to believe it is a widespread problem. I reality, from 1975 through 2015, the average chance of dying in an attack by a foreign-born terrorist on U.S. soil was 1 in 3,609,709 a year. For 30 of those 41 years, no Americans were killed on U.S. soil in terrorist attacks caused by foreigners or immigrants.

The Cycle of Fear

Thus, fear results in probability neglect and confirmation bias. These cause more fear, which leads to more probability neglect and confirmation bias, and so on.

Lets go back to our example with Mary. As an adult, Mary is still struggling with the problems that she faced as a child. She doesnt trust easily: how could she trust someone when her own father let her down so many times? She is closed off to love and to the world, and believes that the only person she needs to lookout for is herself. The human brain is a stress-prone machine that responds immediately to threats. Thus, fear (the brains response to a specific danger) and anxiety (the response to an uncertain danger) can be used to influence behavior.

Authoritarian regimes use these tools as a leverage to gain power. These regimes manipulate people by offering them simple ways to deal with their fear and anxiety: during difficult times, the authoritarian regime only requires a scapegoat to take advantage of the limited capability of the people for exploratory decision making. Through manipulative techniques, authoritarian governments do not permit freedom of speech and look to control every aspect of the daily lives of their citizens. Examples of this type of government can still be found today, in countries like North Korea, Zimbabwe and Belarus.

How can we avoid allowing politicians to manipulate us with fear and anxiety? As individuals we can take the following proactive steps in important pre-decisional periods, such as during political campaigns:

By slowing down the pace of our brains, we reduce the riskiness of our behaviors (including the political ones), and increase the likelihood of meaningful and rational decisions.

Questions to consider:

P.S. Tired of lies in politics? Take the Pro-Truth Pledge, a research-based strategy to get politicians and other public figures to tell more truth and less lies, and push your elected representatives to do the same!

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Connect with Dr. Gleb TsipurskyonTwitter, onFacebook, and onLinkedIn, and follow his RSS feed and newsletter.

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Politics and the Neuroscience of Fear - Patheos - Patheos (blog)

TV Guy: Adding razzle-dazzle to neuroscience – recordonline.com – Times Herald-Record

Kal Penn returns to host a second season of "Superhuman" (9 p.m., Fox, TV-PG).

Though the title may make some think of incredible feats of strength, the game show-like spectacle showcases people with remarkable gifts.

While most talent shows feature singers and dancers who have practiced on their abilities for years, the folks on "Superhuman" appear to have brains and bodies that have been wired a little differently, giving them unique skills that few of us could ever possess.

This season opener features a woman who perceives sounds and, more particularly, musical notes, as color. You have to see it!

A goofy guy from Brooklyn has the uncanny ability to tell the differences in nearly identical objects, allowing him to find the one brush stroke (out of 10,000 or so) that distinguishes one Monet reproduction from another.

There's a gymnast with a terrifyingly precise muscle memory and a man who can identify the sounds of thousands of species of frogs.

And there's also someone with a case of run-of-the-mill photographic memory.

It seems odd to call these folks "contestants." While they are vying for a $50,000 prize, you can't really call this a competition.

They have to appeal to Penn and celebrity judges Mike Tyson and Christina Milian to move forward.

Camera-ready neuroscientist Dr. Rahul Jandial is also on hand to explain how the players' brains and bodies allow them to perform their peculiar "acts."

Despite the presence of this scientific expert, "Superhuman" has the feel of a Las Vegas show.

There's even an appearance by the Blue Man Group in the first episode. Did I mention Mike Tyson?

Since there's really no objective way to determine a "winner," the prize in tonight's episode goes to the most "entertaining" ability. Even I could see that coming a mile away.

- Showtime dedicates four nights to "The Putin Interviews" (9 p.m., Showtime, TV-PG), a series of sit-downs between Russian leader Vladimir Putin and filmmaker Oliver Stone.

The event will reflect more than a dozen conversations conducted over a two-year period. The most recent took place in February.

As Megyn Kelly's recent interview showed us, speaking with Putin may be a casting coup, but it does not necessarily make for compelling television.

For starters, the presence of translators stifles the flow of conversation. Secondly, Putin is a poker-faced former spymaster whose emotions seem to run the gamut from chilly disdain to contemptuous anger.

Showtime has compared this to the David Frost-Richard Nixon conversations from 1977, but compared to Putin, Nixon now seems like Mr. Warmth.

Tonight's other highlights

- "American Ninja Warrior" (8 p.m., NBC, TV-PG) enters its ninth season in Los Angeles.

- Cat Deeley, Nigel Lythgoe and Mary Murphy return for the 14th season of "So You Think You Can Dance" (8 p.m., Fox, TV-14). Vanessa Hudgens joins as a guest judge.

- If required, the Cleveland Cavaliers and Golden State Warriors will meet in Game 5 of the NBA Finals (9 p.m., ABC).

- Trouble over Ireland on "Scorpion" (10 p.m., CBS, r, TV-14).

- Apolo Ohno and Kelvin Washington host "Spartan: Ultimate Team Challenge" (10 p.m., NBC, TV-PG), entering its second season.

- During a reunion with a pal, Jimmy resumes old ways on "Better Call Saul" (10 p.m., AMC, TV-14).

Series notes

Problems solved on "Kevin Can Wait" (8 p.m., CBS, r, TV-PG) ... The president (Lynda Carter) visits town on "Supergirl" (8 p.m., CW, r, TV-14) ... Thanksgiving plans unravel on "Man With a Plan" (8:30 p.m., CBS, r, TV-PG) ... Cold comfort on "Mom" (9 p.m., CBS, r, TV-14) ... On two episodes of "Whose Line Is It Anyway?" (CW, TV-14), Candace Patton (9 p.m.), Brett Dier (9:30 p.m., r) ... Reality bites on "Life in Pieces" (9:30 p.m., CBS, r, TV-14).

Late night

Roxane Gay is booked on "The Daily Show With Trevor Noah" (11 p.m., Comedy Central) ... Will Arnett, Rory Scovel and Luis Fonsi appear on "Conan" (11 p.m., TBS) ... Jimmy Fallon welcomes Demi Moore, Demetrius Shipp Jr., Nathaniel Rateliff, Charles Berry Jr. and Charles Berry III on "The Tonight Show" (11:35 p.m., NBC) ... Elisabeth Moss, John Mulaney, Brett Eldredge and Eric Moore visit "Late Night With Seth Meyers" (12:35 a.m., NBC) ... Salma Hayek and Sofia Coppola appear on "The Late Late Show With James Corden" (12:35 a.m., CBS).

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TV Guy: Adding razzle-dazzle to neuroscience - recordonline.com - Times Herald-Record

S&S buy two from Neuroscience graduate – The Bookseller

Simon & Schuster has bought a debut science fiction novel by a Neuroscience graduate.

Simon & Schuster has bought a debut science fiction novel by a Neuroscience graduate.

The publishers editorial director, Anne Perry, pre-empted world English language rights for Do you dream of Terra-Two?by Temi Oh as part of a two-book deal from Judith Murray of Greene & Heaton and will publish the title in spring 2019.

The novel begins a century ago with scientists who believed that a habitable planet existed in a nearby solar system. In the modern day, 10 astronauts depart a dying Earth to find it. An S&S spokesperson said: It will take the team 23 years to reach Terra-Two, years spent in close quarters with no one to rely on but each other and no rescue possible, should something go wrong.The Long Way to a Small, Angry Planet meets The 100 in this unforgettable debut by a brilliant new voice.

Oh graduated from Kings College London in 2015 with a BSci in Neuroscience where she studied topics such as 'Philosophy of the Mind' and 'Space Physiology'. While at KCL, she founded a book-club,Neuroscience-fiction,where she lead discussions about science fiction books which focus on the brain. Ohbegan writing the novel before receiving an MA in creative writing from the University of Edinburgh.

Perry said: Terra-Two had me gripped from the first page indeed, I became so absorbed in it while on a train journey that another passenger actually tapped me on the shoulder to ask what I was reading. Temi writes with incredible power and imagination, and with such heart that I know readers will fall as hard for her book as I have. Im thrilled to welcome her to Simon & Schuster.

Oh said: I am so lucky to be working with Anne Perry at Simon & Schuster and very grateful for their response to my book. I feel as if Ive taken Terra-Two everywhere with me for the past couple of years, stayed up many nights to write it, and even typed paragraphs out on my phone during parties, or scribbled chapters of it on paper-bags while temping in shops."

Murray said: Temis debut novel Terra-Two took my breath away: I love the ambition and scope of Temis world, the sense of awe she inspires as she shows what human beings can aspire to and achieve and most of all the delicious pleasure of her wonderful story-telling and creation of characters you fall in love with." She added: "I think Temi has a great future ahead of her."

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S&S buy two from Neuroscience graduate - The Bookseller

Neuroscience, Oncology Leaders Gather to Advance Brain Tumor Research at Feinstein Institute’s Brain Tumor Biotech … – PR Newswire (press release)

Brain tumors and CNS diseases can be very difficult to treat as most chemotherapy drugs cannot penetrate the blood-brain barrier, a natural defense mechanism that prevents substances in the bloodstream from getting into the brain. In addition, depending on the location of the tumor, surgery may not be possible. The 2017 Brain Tumor Biotech Summit examined some of the latest therapies aimed at conquering these challenges, including immunomodulatory therapies for glioblastoma multiforme (GBM), which uses the body's immune system to attack cancer cells, novel technologies to overcome the blood brain barrier to administer essential medications, and other innovative treatments for malignant glioma.

"Events like the Brain Tumor Biotech Summit inform medical professionals about new therapies on the horizon or currently being tested in the clinic, while also making those essential connections to spark new ideas and accelerate the development of novel therapies," said Marc Symons, PhD, co-director of the Feinstein Institute's Brain Tumor Biotech Center.

Along with discussing the latest therapies, attendees of the summit were given advice on best practices to maintain funding for research, and to start up and maintain a biotech company in the neuro-oncology space. This included a fireside chat with CNBC anchor Andrew Sorkin and a venture capital/investor panel led by biotech leader Franklin Berger.

About the Feinstein InstituteThe Feinstein Institute for Medical Research is the research arm of Northwell Health, the largest healthcare provider in New York. Home to 50 research laboratories and to clinical research throughout dozens of hospitals and outpatient facilities, the Feinstein includes 4,000 researchers and staff who are making breakthroughs in molecular medicine, genetics, oncology, brain research, mental health, autoimmunity, and bioelectronic medicine a new field of science that has the potential to revolutionize medicine. For more information about how we empower imagination and pioneer discovery, visit FeinsteinInstitute.org

Contact:Heather E. Ball 516-465-7917 hball@northwell.edu

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/neuroscience-oncology-leaders-gather-to-advance-brain-tumor-research-at-feinstein-institutes-brain-tumor-biotech-summit-300471807.html

SOURCE Feinstein Institute for Medical Research

http://www.feinsteininstitute.org/

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Neuroscience, Oncology Leaders Gather to Advance Brain Tumor Research at Feinstein Institute's Brain Tumor Biotech ... - PR Newswire (press release)