Category Archives: Neuroscience

Neuroscience

A New Year Resolution That May Help You Keep Your Other Resolutions – Thrive Global

And, it is so simple, that it may be THE resolution you can keep.

Drink more water every day.

Youhave heard the fact that our bodies are mostly water. About 70% of body weight.But did you know that many medical experts say that water is the most criticalsubstance we can consume?

Over80% of people report that they dont drink enough water. And 75% of peopleare reportedly dehydrated.

Thebenefits of water and hydration have been around for years. (Remember theslogan You should drink 8, 8-ounce glasses of water a day. For me, that neverworked. Estimating eight ounces was tough, and then the pressures of the daywould make me lose count.) It is clear our bodies need water. Water isessential for kidney function, blood glucose levels, and joint lubrication. Italso regulates our body temperature and promotes proper digestion.

Toname a few reasons.

Butnow, neuroscience tells us that our brains need water too for peak performance.Being creative. Thinking clearly. Remembering where you put your keys.

Our brains are 73% water. Without proper hydration, our cognitive abilities decline, and our thinking can become cloudy. We are subject to mood swings, and we are more prone to anger. None of the behaviors that match up to New Years goals.

Thequestion then becomes, How much water should I drink?

Youcould go by the old 8 X 8-ounce glasses, or..

Drink MORE than you are drinking now.

Nowyou may ask, If I dont know how much I am drinking now, how will I know if Iam drinking more?

Greatquestion!

If you are like me, you only drink (water) when thirsty. For 2020, commit to having some water BEFORE you get thirsty. Thirst is a message your brain sends you to say, feed me. When you get this message, it is past the time you should have refueled.

Makea resolution to drink more water. Your brain will thank you for it.

AlRoehl

Leadership Excellence thru Neuroscience

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A New Year Resolution That May Help You Keep Your Other Resolutions - Thrive Global

Neuroscience

MIND Research Institute Unveils All-New Version of ST Math – GlobeNewswire

ST Math games and JiJi have a fresh new look!

JiJi holds a laptop with the all-new version of MIND's flagship program, ST Math.

Irvine, Calif., Jan. 09, 2020 (GLOBE NEWSWIRE) -- MIND Research Institute, an award-winning neuroscience and education social impact organization dedicated to ensuring that all students are mathematically equipped to solve the worlds most challenging problems, today announced the launch of an all-new version of its flagship solution,ST Math.

Based on 20 years of neuroscientific research and thebelief that every student has the potential to deeply understand and love math,ST Math uses spatial-temporal games to present math concepts visually for students in grades preK8. This patented approach leverages the brains innate spatial-temporal reasoning abilities to solve math problems.

The mastery-based and standards-aligned ST Math offers equitable access to learning through challenging puzzles, non-routine problem solving, and informative feedback. Proving that a game can change how students feel about math, the unique approach delivers robust results on a national scale. Independent education research firm WestEd recently published the largest ever cross-state study evaluating a math edtech program on multiple state assessments. The results were especially significant at the 239 schools that used ST Math consistently. These high-fidelity schools outgrew similar schools in statewide rank by an average of 14 percentile points.

The newest version is built on the latest website technology, featuring responsive design to work seamlessly on any device. Designed to deepen and extend engagement to maximize learning time, the update gives ST Maths beloved mascot, JiJi, and all the puzzles and environments a fresh new look. The update also allows students to track their logins, minutes played, and puzzles solved each week to improve accountability and intrinsic motivation.

For administrators, ST Math now has more streamlined implementation focused on single sign-on and account provisioning, as well as new reporting tools that offer comprehensive student data to uncover insights and track student learning results.

Improvements for teachers will help them implement the program with greater fidelity, integrate it with core curriculum more easily, and better support student learning. Key features for teachers in the new version include:

Our whole team at MIND Research Institute have been hard at work on the new ST Math, and we are so excited for students, teachers, and administrators to experience it, said Brett Woudenberg, CEO of MIND. Our partners asked for increased flexibility and even more reporting and student details. The new ST Math delivers all of that and more, helping students and teachers alike to deeply understand and truly love math.

ST Math meets What Works Clearinghouse (WWC) quasi-experiment and ESSA Tier 2 requirementsand has won numerous awards, most recently including two CODiE Awards in 2019 for Best Mathematics Instructional Solution for Grades PreK-8 and Best Overall Education Technology Solution.

To learn more about the new version of ST Math, which is available for the 2020-2021 academic year, go tostmath.com/whats-new. For those attending FETC, Vice President of Engagement Elizabeth Neiman will be available for meetings and can be reached ateneiman(at)mindresearch(dot)org.

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About MIND Research InstituteMIND Research Institute is a neuroscience and education social impact organization dedicated to ensuring that all students are mathematically equipped to solve the worlds most challenging problems. MIND is the creator of ST Math, a PreK-8 visual instructional program that builds a deep conceptual understanding of math through rigorous learning and creative problem solving. MIND has also developed programs under MathMINDs to provide students, teachers, and families dynamic ways to actively engage with math and to close the experience gap for all learners. MathMINDs includes Family Game Nights, the national K-12 Game-a-thon, and MathMINDs Games. For more information, visitmindresearch.org.

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MIND Research Institute Unveils All-New Version of ST Math - GlobeNewswire

Neuroscience

The Six Workplace Wellness Trends you need to know about in 2020 – Thrive Global

Do you already have a successful workplace well-being strategy in place?

If so, how did you measure it 2019? What annual impacts on behaviour, HR measures and business outcomes, did it achieve? How will you adjust it according to the changing needs of your workforce composition and structure in 2020?

This article outlines what you need to know about changes coming to workplace well-being in 2020. As technology fragments tools, behaviours and processes and rewrites internal communications structures, organisations need to understand, embrace and integrate their business with their employees at the center.

If the employees well-being is not considered as a key stakeholder business need, an organisation will now lose its competitive advantage. As millennials flock to organisations who promise to deliver employee-centric wellbeing, leadership and connection-based programs.

To assess whether we have an employee-centric well-being culture, we need to ask:

1. Whom makes up the majority of our workforce?

2. How do we create a culture of well-being that motivates engagement, presenteeism and retention in our workforce?

3. How do we break down current cultural roadblocks to proceeding with optimal workplace well-being; a sense of success, purpose, leadership, opportunity and appreciation?

What are the current organisational costs of not providing optimal workplace well-being?

4. What are the current organisational costs of not providing optimal workplace well-being? These costs are significant and represent missed opportunities for employees and employers. They can be measured by turnover, absenteeism, presenteeism, levels of stress, workplace burnout and workers compensation. Ultimately, it will cost the business more in employer brand value as it struggles to attract the best talent.

So lets review six global workplace wellness trends to embed in your organisation for 2020.

To keep pace with change, organisations should regularly review HR based goals and organisational goals for productivity, turnover, customer complaint levels, error levels, workplace health and safety standards .

These metrics should be aligned with workplace Well-being Programs including retention, turnover, stress levels and mental health issues. This audit should help to keep you abreast of changing technology, societal conditions, and worker satisfaction/engagement levels. The results may include the following:

Millennials as the largest growing body of employees from 2020 on are different leaders than the Baby Boomers and Gen Xers of the past. Millennials will leave if an organisation has not dealt with structural issues causing workplace burnout. This includes excessive work hours, poor communication, or change management issues. Three of every 4 employees in this 2019 study say they experienced workplace burnout.

Recent research by Class pass , Oct 2019 , revealed 75% of professionals believe its the employers responsibility to provide health and well-being benefits. With more than half stating they would stay with a company longer if they provided fitness and wellness benefits.

Generational conflict exists as we now have 5 different generations in the workforce. Millennials have different attitudes toward authority, flexibility and work ethic. There are also differences in customs i.e.: values of respect and standards of courtesy and behaviours like eye contact. Whilst Millennials and Gen Zeds maybe flying along with technology, their emotional intelligence and organisational communication tends to be poorer due to their screen based upbringing.

Millennials expect more from their employers than did their parents, they are now becoming leaders who expect change:

SOURCE: OCTANNER Global Culture Report, 2018

Simple participation in learning lunches or wellness activities does not lead to behaviour change. Buy in by key stakeholders such as the CEO, executive team and HR/People and Culture are necessary to produce a real return on investment for well-being programs.

This can be benefits such as the lowering of insurance costs and reductions on workerscompensation claims

This can be benefits such as the lowering of insurance costs and reductions on workers compensation claims as well as traditional metrics such as reduced turnover, absenteeism, stress levels and retention. Investing in both people and benefits will ignite productivity, improve workforce attraction and company culture long-term, says Workforce.com.

Habit change takes at least 60 days according to neuroscience research. So, programs that support employees at work and at home, that are engaging, novel, social and measurable provide greater chance of success. Providing employees opportunities for in-person connection and resources to incorporate healthy living both at work and at home are essential for embedding change.

For example:

Whilst, stress relief tools such as tracking steps or company fitness challenges have been popular and useful for the last decade or so, there has been absence of mental self-care and psychological well-being programs.

With greater awareness of the issues of mental health in our community and at work (1 in 5 have a mental health issue at any one time) and the complex issues of bullying, harassment and negligence due to suicide. Employers must see this as partly their responsibility to bear.

Well-being Initiatives need to relate to an employees total health and wellbeing not just one aspect of it. Tools to deal with workplace stress as well as personal stress may include:

Emotional Intelligence tools, education and coaching

Encouragement to connect with team members in non-work related activities such as walk and talk program, meditation together physically or via an app.

Sleep or rest pods, deep breathing practice, mindfulness and compassion practice

Include financial wellness programs for all employees:

As financial hardship is one of the major stressors facing individuals, offering in-house financial counseling and programs targeted to individual employees needs are a huge benefit. They can relieve stress, improve productivity and appreciation, engagement with the organisation.

Financial wellness programs can include salary sacrifice options, tuition reimbursement for training and study, credit counsellors and financial concierge services. Also providing resources to help employees with challenges at home (caregiving, counselling, budgeting, etc.).

There has been much work done in organisations over recent years in de-emphasising autocratic, egoistic, topdown, leadership and management style thinking and practice. In order to practice this concept, individuals and leaders who have embraced an egoistic non-inclusive style will need awareness and insight training and an understanding of the concepts of emotional intelligence in a team and organisational context.

Organisations who emphasise inclusion and compassion not just diversity have higher Culture Scores

Whilst Diversity Policy is a necessary and perhaps legal requirement for many organisations, diversity emphasises difference which can be tribalising and entrench separateness and feelings of otherness between groups at work rather than collaboration and compassion. Organisations who emphasise inclusion and compassion not just diversity have higher culture scores.

Compassionate, inclusive organisations create employees who focus on working together for the common good of the organisation and community. To do this people need to feel valued and understood by others for their individual and authentic self. Cultures who achieve this foster value, pride and commitment to their organisation and filled with purpose.

There is a big difference in culture scores when people feel they work in an inclusive environment:

Most employees spend more time at work than they do at home with their families on a given day. Work and home life has become integrated, no longer work/life balance. Connections and relationships at work create a more positive work experience. Thats important when you work work 8-12 hours a day, 5 days a week.

People want to connect with their second family.

Loneliness isnt the physical absence of other people. Its the sense that youre not sharing anything that matters with anyone else. You have to be in it togetherand it can be anything that you both think has meaning and value.

JOHN CACIOPPO, NEUROSCIENCE RESEARCHER

Connections promote a sense of belonging. Humans are social creatures, we want to be needed, connected and belong. We are wired to be social want to interact with other people. A lone monkey is a dead monkey. We want to fit in and belong to our organisation. We want to feel part of a team. A lack of connection leads to loneliness, stress and uncertainty of whether or not the employee belongs in the organisation.

Connections create a feeling of establishing purpose and making a difference.

Employees arent there just for the paycheck, particularly millenials. They want to feel a part of something bigger, contribute toward a meaningful purpose, make a difference in the world. They want to strive for a common goal together.

Let me know how your organisation has built a culture of belonging, purpose, and mental flourishing. And join us in Melbourne FEB 20 or Sydney FEB 28 for breakfast to discuss building your culture of Well-being.

Originally published on Linkedin January 1, 2020 https://www.linkedin.com/pulse/six-workplace-wellness-trends-you-need-know-2020-jennifer-bishop/

Contact [emailprotected]

#workplacehealth #wellbeing #mentalhealth #2020

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The Six Workplace Wellness Trends you need to know about in 2020 - Thrive Global

Neuroscience

Scientists Probe the Mysteries of a Well-Preserved 2,500-Year-Old Human Brain – VICE

Some time between the years of 673 and 482 BCE, a man was killed in northern England near the modern town of Heslington. His head was severed from his body and tossed into a pit, and any trace of his existence was lost for thousands of years.

Then, in 2008, archeologists unearthed the mans skull and were stunned to find that his brain had been preserved in incredible detail. The unusually intact condition of the so-called Heslington Brain has puzzled researchers for more than a decade, because neural tissue normally disintegrates rapidly after death. The Heslington Brain turned this pattern on its head because it was the only tissue matter in the skull that did not decompose.

To probe the mystery of the brains survival, researchers led by Axel Petzold, a neurologist at University College London, spent a year examining tissue samples using a variety of molecular techniques.

The results, published on Wednesday in the Journal of the Royal Society Interface, suggest that special proteins in the brain were spared from the putrefying effects of enzymes, enabling them to form strong aggregates that withstood decay. The research not only sheds light on the properties of this ancient organ, but also has applications for modern neuroscience and archeology.

The preservation of human brain proteins at ambient temperature should not be possible for millennia in free nature, said Petzolds team in the study. Therefore, the yellowish-brown mass of the Heslington Brain offers a unique opportunity to use molecular tools to investigate the preservation of human brain proteins, they added.

Images of the Heslington Brain. Image: Axel Petzold et al.

While the Heslington specimen is not the only example of exceptional brain preservation in the archeological record, it is notable because there was no sign of hair, skin, or any other soft tissue other than the neural tissue, the team said.

To pinpoint what may have been different about this brains afterlife, Petzold and his colleagues watched tissues sourced from both the ancient specimen and a modern brain as they decomposed over an entire year. The team also analyzed samples with precision techniques such as mass spectrometry and observed the behavior of antibodies generated from the ancient brain cells.

The experiments isolated intermediate filaments, a type of neural connective structure, as a key source of stability in the Heslington Brain. While brain tissues are normally broken down by enzymes called proteases after death, these filaments in the ancient brain remained resistant to their effects. Instead, the filaments formed strong protein aggregates that contributed to the organs overall structural integrity and preservation.

Its still not clear why the filaments toughed it out, but the researchers speculated that some type of preservative compound might have leaked into the skull from the sediment at the burial site.

Combined, the data suggest that the proteases of the ancient brain might have been inhibited by an unknown compound which had diffused from the outside of the brain to the deeper structures, the team said in the study.

The results have implications for unraveling the mechanisms behind neurodegenerative conditions related to aggregate formation, such as Alzheimers disease or Creutzfeldt-Jakob disease.

So while this mans last thoughts were probably bleak, given that experts suspect he was the victim of an execution or a ritual murder, his brain may help people live healthier lives some 2,500 years after his own death.

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Scientists Probe the Mysteries of a Well-Preserved 2,500-Year-Old Human Brain - VICE

Neuroscience

Rehab Therapy Works Opens New Clinic in Trinity – PR Web

Joe Lavore, Founder of Rehab Therapy Works

TRINITY, Fla. (PRWEB) January 09, 2020

Rehab Therapy Works (RTW) is pleased to announce their newest physical therapy clinic opened January 2nd, in Trinity, FL. Located at 1839 Health Care Drive, the clinic is RTWs 10th location.

RTW specializes in providing exceptional physical therapy through a combination of evidence-based practice, care excellence, and clinical excellence. Services offered from the Trinity clinic will include manual and orthopaedic physical therapy and Pain Neuroscience Education.

Our patients and physicians have trusted the Rehab Therapy Works name and services for over 20 years. We are pleased to be extending these services to the Trinity and New Port Richey areas, said Joe Lavore, PT and founder of the Rehab Therapy Works clinics in Spring Hill and Hudson.

Randy Wiemer, PT, DPT, serves as the Trinity Clinic Director alongside Kim Eneberg, PT, a full-time primary treating physical therapist.

"I am so excited to have rung in the new year by opening the newest Rehab Therapy Works location in Trinity, says Wiemer. This clinic is a great opportunity for us to meet the needs of our patients and offer excellent customer service/care to the Trinity community. I look forward to helping the community work to achieve their optimal level of function.

For more information about the new Trinity clinic and a full list of RTWs services and offerings, please visit https://www.myrtw.com/.

To book an appointment, please call 727-339-1180.

About Rehab Therapy WorksSince 1998, Rehab Therapy Works (RTW) has served Florida residents with outpatient physical, occupational, and speech therapy services across three locations in Hudson, Trinity, and Spring Hill, Florida. RTW remains physical therapist owned and committed to developing strong, independent physical therapists serving the residents of in their local communities. As a proud Medicare-certified rehab agency, we accept Medicare, workers compensation, private pay and most insurances. For more information on Rehab Therapy Works, please visit http://www.myrtw.com.

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Rehab Therapy Works Opens New Clinic in Trinity - PR Web

Neuroscience

Using Tools of Neuroscience to Make Personalized Care a Reality in Schizophrenia – A Free Webinar from the Brain & Behavior Research Foundation -…

New York, Jan. 08, 2020 (GLOBE NEWSWIRE) -- The Brain & Behavior Research Foundation is hosting a free webinar Using Tools of Neuroscience to Make Personalized Care a Reality in Schizophrenia on Tuesday, January 14, 2020, from 2pm to 3pm ET. Gregory A. Light, Ph.D., University of California, San Diego, will be the presenter.

Dr. Light will describe precision medicine trials his team has conducted which significantly reduced symptoms and improved cognitive and daily functioning in patients with chronic psychosis in a real-world setting: a long-term community inpatient facility. They also found that reliable, easy-to-obtain signatures of brain-wave activity recorded at the outset of treatment can be used to identify which patients are most likely to benefit (or not) from treatments. This work ultimately aims to develop personalized biomarker assessment tools to deliver the right treatment to the right person at the right time, to improve outcomes among the millions of people with psychotic disorders, most notably schizophrenia.Jeffrey Borenstein, M.D., President and CEO of the Brain & Behavior Research Foundation and Host and Executive Producer of the public television series Healthy Minds, will be the moderator. Join by phone or on the web at bbrf.org/januarywebinar.

This webinar is part of a series of free monthly Meet the Scientist webinars on the latest developments in psychiatry offered by the Brain & Behavior Research Foundation.

The Brain & Behavior Research Foundation The Brain & Behavior Research Foundation awards research grants to develop improved treatments, cures, and methods of prevention for mental illness. These illnesses include addiction, ADHD, anxiety, autism, bipolar disorder, borderline personality disorder, depression, eating disorders, OCD, PTSD, and schizophrenia, as well as research on suicide prevention. Since 1987, the Foundation has awarded more than $408 million to fund more than 4,800 leading scientists around the world, which has led to over $4 billion in additional funding. 100% of every dollar donated for research is invested in research grants. BBRF operating expenses are covered by separate foundation grants. BBRF is the producer of the Emmy nominated public television series Healthy Minds with Dr. Jeffrey Borenstein, which aims to remove the stigma of mental illness and demonstrate that with help, there is hope.

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Using Tools of Neuroscience to Make Personalized Care a Reality in Schizophrenia - A Free Webinar from the Brain & Behavior Research Foundation -...

Neuroscience

ORYZON to Present at the 3rd Neuroscience Innovation Forum in San Francisco – Yahoo Finance

CEO and CMO to present recent progress of vafidemstat

Will also participate in 9th Annual LifeSci Advisors Corporate Access Event 2020

Both events during week of the JP Morgan Healthcare Conference

MADRID, Spain and CAMBRIDGE, Mass., Jan. 08, 2020 (GLOBE NEWSWIRE) -- Oryzon Genomics, S.A. (ISIN Code: ES0167733015, ORY), a public clinical-stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases with strong unmet medical need, announces that its management will present recent progress of vafidemstat in central nervous system (CNS) indications at the 3rd Neuroscience Innovation Forum in San Francisco on January 12.

Vafidemstat is in Phase II clinical development in multiple trials. It has demonstrated promise as a safe, well-tolerated and differentiated therapeutic option for treating agitation and aggression, and for treating non-aggressive features of three distinct psychiatric diseases.

Oryzons CEO Dr. Carlos Buesa and CMO Dr. Roger Bullock will make the presentation at the Marines' Memorial Club, a day before the JP Morgan Healthcare Conference. Oryzons presentation will take place at 13:50 PT in Track E in the Room Commandants. At the same event, Dr. Buesa will also participate in the Advances in Alzheimers & Other Cognitive Disorders Panel discussion at 9:30 am PT.

Oryzon will also take part in the 9th Annual LifeSci Advisors Corporate Access Event from January 13 to January 15, 2020 where Oryzons CEO and other management will hold meetings with pharmaceutical companies, institutional investors, analysts and other members of the biotech community at the Sir Francis Drake Hotel (450 Powell Street).

About OryzonFounded in 2000 in Barcelona, Spain, Oryzon (ISIN Code: ES0167733015) is a clinical stage biopharmaceutical company considered as the European champion in Epigenetics. Oryzon has one of the strongest portfolios in the field. Oryzons LSD1 program has rendered two compounds, vafidemstat and iadademstat, in clinical trials. In addition, Oryzon has ongoing programs for developing inhibitors against other epigenetic targets. Oryzon has a strong technological platform for biomarker identification and performs biomarker and target validation for a variety of malignant and neurodegenerative diseases. Oryzon has offices in Spain and the United States. For more information, visit http://www.oryzon.com.

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About VafidemstatVafidemstat (ORY-2001) is an oral, CNS optimized LSD1 inhibitor. The molecule acts on several levels: it reduces cognitive impairment, including memory loss and neuroinflammation, and at the same time has neuroprotective effects. In animal studies vafidemstat not only restores memory but reduces the exacerbated aggressiveness of SAMP8 mice, a model for accelerated aging and Alzheimers disease (AD), to normal levels and also reduces social avoidance and enhances sociability in murine models. In addition, vafidemstat exhibits fast, strong and durable efficacy in several preclinical models of multiple sclerosis (MS). Oryzon has performed a Phase IIa clinical trial in aggressiveness in patients with different psychiatric disorders (REIMAGINE), with positive preliminary clinical results reported. Additional Phase IIa clinical trials with vafidemstat are ongoing in patients with Mild to Moderate AD (ETHERAL), in aggressiveness in patients with moderate or severe AD (REIMAGINE-AD), and in Relapse-Remitting and Secondary Progressive MS (SATEEN).

About IadademstatIadademstat (ORY-1001) is a small oral molecule, which acts as a highly selective inhibitor of the epigenetic enzyme LSD1 and has a powerful differentiating effect in hematologic cancers (See Maes et al., Cancer Cell 2018 Mar 12; 33 (3): 495-511.e12.doi: 10.1016 / j.ccell.2018.02.002.). A first Phase I/IIa clinical trial with iadademstat in refractory and relapsed acute leukemia patients demonstrated the safety and good tolerability of the drug and preliminary signs of antileukemic activity, including a CRi. Beyond hematological cancers, the inhibition of LSD1 has been proposed as a valid therapeutic approach in some solid tumors such as small cell lung cancer (SCLC), medulloblastoma and others. Oryzon is currently conducting two Phase IIa clinical trials of iadademstat in combination; the first one in combination with azacitidine in elderly AML patients (ALICE study) and the second one in combination with platinum/etoposide in second line SCLC patients (CLEPSIDRA study). In both studies, preliminary clinical results have been reported.

FORWARD-LOOKING STATEMENTS This communication contains, or may contain, forward-looking information and statements about Oryzon, including financial projections and estimates and their underlying assumptions, statements regarding plans, objectives and expectations with respect to future operations, capital expenditures, synergies, products and services, and statements regarding future performance. Forward-looking statements are statements that are not historical facts and are generally identified by the words expects, anticipates, believes, intends, estimates and similar expressions. Although Oryzon believes that the expectations reflected in such forward-looking statements are reasonable, investors and holders of Oryzon shares are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Oryzon that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include those discussed or identified in the documents sent by Oryzon to the Spanish Comisin Nacional del Mercado de Valores (CNMV), which are accessible to the public. Forward-looking statements are not guarantees of future performance and have not been reviewed by the auditors of Oryzon. You are cautioned not to place undue reliance on the forward-looking statements, which speak only as of the date they were made. All subsequent oral or written forward-looking statements attributable to Oryzon or any of its members, directors, officers, employees or any persons acting on its behalf are expressly qualified in their entirety by the cautionary statement above. All forward-looking statements included herein are based on information available to Oryzon on the date hereof. Except as required by applicable law, Oryzon does not undertake any obligation to publicly update or revise any forwardlooking statements, whether as a result of new information, future events or otherwise. This press release is not an offer of securities for sale in the United States or any other jurisdiction. Oryzons securities may not be offered or sold in the United States absent registration or an exemption from registration. Any public offering of Oryzons securities to be made in the United States will be made by means of a prospectus that may be obtained from Oryzon or the selling security holder, as applicable, that will contain detailed information about Oryzon and management, as well as financial statements.

IR & Media, US & Europe:

Spain:

Oryzon:

LifeSci Advisors LLC

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Emili Torrell

Hans Herklots

Patricia Cobo/Idoia Revuelta

BD Director

+41 79 598 7149

+34 91 564 07 25

+34 93 515 13 13

hherklots@lifesciadvisors.com

pcobo@atrevia.comirevuelta@atrevia.com

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ORYZON to Present at the 3rd Neuroscience Innovation Forum in San Francisco - Yahoo Finance

Neuroscience

BrainStorm Cell Therapeutics to Present at the 2020 Biotech Showcase and 3rd Annual Neuroscience Innovation Forum at JPM Week – StreetInsider.com

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BrainStorm Cell Therapeutics to Present at the 2020 Biotech Showcase and 3rd Annual Neuroscience Innovation Forum at JPM Week - StreetInsider.com

Neuroscience

AI-based motion-capture system for animals has applications from drug development to ecology – Princeton University

A new system that uses artificial intelligence to track animal movements is poised to aid a wide range of studies, from exploring new drugs that affect behavior to ecological research. The approach, shown in the video above, can be used with laboratory animals such as fruit flies and mice as well as larger animals.

The technology developed by Mala Murthy, professor of neuroscience; Joshua Shaevitz, professor of physics and the Lewis-Sigler Institute for Integrative Genomics; Talmo Pereira, graduate student in neuroscience; and then-undergraduate Diego Aldarondo of the Class of 2018 accurately detects the location of each body partlegs, head, nose and other pointsin millions of frames of video.

First, a human experimenter records video of a moving animal. Next, the experimenter directs the systems software to identify a small number of images in which to define body part positions. The system then uses this data set to train a neural network to calculate the location of the points in subsequent frames. The method has recently been extended by Pereira to work not only on videos of a single animal but also on footage of multiple interacting animals, keeping track of animal identities over time.

Funding sources included the National Science Foundation and the National Institutes of Health.

This technology was featured at the annual Celebrate Princeton Innovation (CPI) event in November that highlights the work of faculty and student researchers who are making discoveries and creating inventions with the potential for having broad societal impact. The gathering attracts members of the broader entrepreneurial ecosystem outside the University such as members of the venture capital community, industry, as well as representatives from state and local governments who come to learn about the newest University discoveries and meet the faculty and staff engaged in Princetons innovation initiative.

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AI-based motion-capture system for animals has applications from drug development to ecology - Princeton University

Neuroscience

Stress-recovery wearable helps the body bounce back with Covestro polycarbonate blend – PRNewswire

According to Kathryn Fantauzzi, CEO and co-founder of Apollo Neuroscience, Inc., Apollo is the first wearable that helps the body beat stress by rapidly restoring its natural equilibrium for better sleep, energy and more. She explains that, unlike other wearables, Apollo doesn't just track your bodyit uses vibration to improve your recovery from stress. Originally developed by physicians and neuroscientists at the University of Pittsburgh, Apollo's gentle vibration waves signal safety to the body and improve HRVall through the sense of touch.

Since Apollo is worn on the wrist or ankle, the wearable required a material that withstands everyday productssuch as lotions, perfumes and detergentsas well as drops and daily wear and tear. Makroblend M525 PC+polyester blend from Covestro delivers the toughness and chemical resistance needed to create this durable yet lightweight device.

"Wearables have a long checklist of needs to meet, and it all starts with the right materials," said Doug Hamilton, global healthcare marketing leader, Covestro LLC.

Zachary Williams, market development, Healthcare Polycarbonates, Covestro LLC, added, "Makroblend M525 PC+polyester blend meets two important requirementstoughness and chemical resistanceto help Apollo users find balance with a strong and lightweight device that remains unchanged when exposed to a variety of personal care products."

"Apollo is about empowering people to take control of their healththat's why we chose Covestro as a partner," said John Maholtz, chief operating officer at Apollo Neuroscience. "Covestro's premier materials ensure that Apollo users experience a clean, comfortable and long-lasting product that is just as resilient as they are."

The device works in tandem with an intuitive app which, according to Apollo, features a variety of programs that help users:

Attendees at the following shows will be able to experience first-hand how the Apollo device helps their body adapt to stress:

Learn about what else Covestro has in store for CES: http://www.solutions.covestro.com/en/highlights/campaigns/ces-2020.

About Covestro LLC:Covestro LLC is one of the leading producers of high-performance polymers in North America and is part of the global Covestro business, which is among the world's largest polymer companies with 2018 sales of EUR 14.6 billion. Business activities are focused on the manufacture of high-tech polymer materials and the development of innovative solutions for products used in many areas of daily life. The main segments served are the automotive, construction, wood processing and furniture, electrical and electronics, and healthcare industries. Other sectors include sports and leisure, cosmetics and the chemical industry itself. Covestro has 30 production sites worldwide and employed approximately 16,800 people at the end of 2018.

About Apollo Neuroscience:Apollo is the first wearable that actively helps your body adapt to stress, for better sleep, focus, energy, and more. While other wearables track your body, Apollo empowers you to change it, harnessing the power of neuroscience to deliver gentle waves of vibration shown to rapidly restore your body's natural equilibrium. Apollo works by signaling safety to the body and has been scientifically-validated to improve heart rate variability (HRV), a key metric of health and recovery. Apollo has been evaluated in university-led trials and has been tested by over 2,000 users. For more information, visit http://www.apolloneuro.com.

Find more information at http://www.covestro.usorwww.solutions.covestro.com/en/materials/plastics.

Forward-Looking StatementsThis news release may contain forward-looking statements based on current assumptions and forecasts made by Covestro AG. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in Covestro's public reports which are available at http://www.covestro.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

Makroblend is a registered trademark of the Covestro Group.

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Editor's Note: Follow news from Covestro on Twitter: https://twitter.com/CovestroUS

Contact John Skabardonis Telephone +1 412 413 5444 Email John.Skabardonis@covestro.com

SOURCE Covestro LLC

http://www.covestro.com/en

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Stress-recovery wearable helps the body bounce back with Covestro polycarbonate blend - PRNewswire