Category Archives: Neuroscience

Prothena to Report Fourth Quarter and Full Year 2019 Financial Results and Host Webcast Conference Call on February 12 – Yahoo Finance

DUBLIN, Ireland, Feb. 05, 2020 (GLOBE NEWSWIRE) -- Prothena Corporation plc (PRTA), a clinical-stage neuroscience company with expertise in protein misfolding, announced today that it will report its fourth quarter and full year 2019 financial results on Wednesday, February 12, 2020 after the close of the U.S. financial markets. The announcement will be followed by a live audio conference call at 4:30 PM ET.

The conference call will be made available on the Company's website at http://www.prothena.com under the Investors tab in the Events and Presentations section. Following the live audio webcast, a replay will be available on the Company's website for at least 90 days.

To access the call via dial-in, please dial(877) 887-5215 (U.S. and Canada toll free) or (315) 625-3069 (international) five minutes prior to the start time and refer to conference ID number 1758808. A replay of the call will be available until February 26, 2020 via dial-in at (855) 859-2056 (U.S. toll free) or (404) 537-3406 (international), Conference ID Number 1758808.

About Prothena Prothena Corporation plc is a clinical-stage neuroscience company with expertise in protein misfolding, focused on the discovery and development of novel therapies with the potential to fundamentally change the course of devastating diseases. Fueled by its deep scientific expertise built over decades of research, Prothena is advancing a pipeline of therapeutic candidates for a number of indications and novel targets for which its ability to integrate scientific insights around neurological dysfunction and the biology of misfolded proteins can be leveraged. Prothenas partnered programs include prasinezumab (PRX002/RG7935), in collaboration with Roche for the potential treatment of Parkinsons disease and other related synucleinopathies, and programs that target tau, TDP-43 and an undisclosed target in collaboration with Bristol-Myers Squibb for the potential treatment of Alzheimers disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) or other neurodegenerative diseases. Our proprietary programs include PRX004 for the potential treatment of ATTR amyloidosis, and programs that target A (Amyloid beta) for the potential treatment of Alzheimers disease.

Media & Investor Contact:

Ellen Rose, Head of Communications650-922-2405, ellen.rose@prothena.com

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Prothena to Report Fourth Quarter and Full Year 2019 Financial Results and Host Webcast Conference Call on February 12 - Yahoo Finance

Neuroscience Antibodies & Assays Market 2020 Future Growth by In Depth Industry Analysis, Size, Trends and Forecast by 2026 – Jewish Life News

New Jersey, United StatesThe report titled, Neuroscience Antibodies & Assays Market Size, Status and Forecast 2020-2026 is comprehensively analyzed by the authors of the report to help players and investors to gain deep understanding of important drivers and restraints, segments, regions, and the vendor landscape. The research analysts have shed light on each and every aspect of the Neuroscience Antibodies & Assays industry and how it may be influenced in the coming years. The revenue, production, consumption, CAGR, share, and other forecasts for the Neuroscience Antibodies & Assays industry are accurate and highly reliable. They have been verified with the help of advanced tools and industry experts. Overall, the report comes out as a useful guide for both leading players and new entrants to obtain growth in the Neuroscience Antibodies & Assays industry.

Neuroscience Antibodies & Assays Market was valued at USD 2.42 Billion in 2018 and is projected to reach USD 5.14 Billion by 2026, growing at a CAGR of 9.7% from 2019 to 2026.

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Key companies functioning in the global Neuroscience Antibodies & Assays Market cited in the report:

Almost all major players operating in the Neuroscience Antibodies & Assays market are included in the report. They have been profiled based on recent developments, geographic expansion, market presence, gross margin, net profit, applications, product portfolio, and a number of other factors. The research analysts have made a brilliant attempt to explain key changes in the vendor landscape, the nature of competition, and future plans of leading players in the Neuroscience Antibodies & Assays industry.

Neuroscience Antibodies & Assays Market: Segment Analysis

To broaden the understanding of the reader, the report has also studied the segments including product type, application, and end user of the Neuroscience Antibodies & Assays market in a comprehensive manner. Apart from that, the market.

Readers of the report can receive in-depth information about different product type and application segments of the Neuroscience Antibodies & Assays industry. The segments included in the report are studied in great detail by the experienced research analysts. They have been analyzed on the basis of several parameters, including share, growth rate, and future growth potential in the Neuroscience Antibodies & Assays industry.

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Neuroscience Antibodies & Assays Market: Regional Analysis :

As part of regional analysis, important regions such as North America, Europe, the MEA, Latin America, and Asia Pacific have been studied. The regional Neuroscience Antibodies & Assays markets are analyzed based on share, growth rate, size, production, consumption, revenue, sales, and other crucial factors. The report also provides country-level analysis of the Neuroscience Antibodies & Assays industry.

Table of Contents

Introduction: The report starts off with an executive summary, including top highlights of the research study on the Neuroscience Antibodies & Assays industry.

Market Segmentation: This section provides detailed analysis of type and application segments of the Neuroscience Antibodies & Assays industry and shows the progress of each segment with the help of easy-to-understand statistics and graphical presentations.

Regional Analysis: All major regions and countries are covered in the report on the Neuroscience Antibodies & Assays industry.

Market Dynamics: The report offers deep insights into the dynamics of the Neuroscience Antibodies & Assays industry, including challenges, restraints, trends, opportunities, and drivers.

Competition: Here, the report provides company profiling of leading players competing in the Neuroscience Antibodies & Assays industry.

Forecasts: This section is filled with global and regional forecasts, CAGR and size estimations for the Neuroscience Antibodies & Assays industry and its segments, and production, revenue, consumption, sales, and other forecasts.

Recommendations: The authors of the report have provided practical suggestions and reliable recommendations to help players to achieve a position of strength in the Neuroscience Antibodies & Assays industry.

Research Methodology: The report provides clear information on the research approach, tools, and methodology and data sources used for the research study on the Neuroscience Antibodies & Assays industry.

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Neuroscience Antibodies & Assays Market 2020 Future Growth by In Depth Industry Analysis, Size, Trends and Forecast by 2026 - Jewish Life News

‘It takes a world’: Initiative urges global collaboration to help us understand the human brain – Genetic Literacy Project

First envisioned in 2016 through a series of discussions on the grand challenges in neuroscience at Johns Hopkins University,the International Brain Initiative (IBI)came out [January 22] in aforward-looking paperinNeuron.

Rather than each country formulating their own brain projects independently, the project argues, its high time for the world to come together and share their findings, resources, and expertise across borders. By uniting efforts, the IBI can help shape the future ofneuroscienceresearch at a global scalefor promoting brain and mental health, for stimulating international collaboration, for ethical neuroscience practices, and for crafting future generations of scientists.

It takes a world to understand the brain,saidCaroline Montojo ofthe Kavli Foundation, which offered support to the project. When we have the best brains and the best minds working together, sharing information and research that could benefit us all.

The initiative, at the time of writing, includes JapansBrain/Minds,Australian Brain Alliance, theEUs Human Brain Project (HBP),Canadian Brain Research Strategy, theUSBRAIN Initiative(BRAINI), theKorea Brain Initiative, and theChina Brain Project.

Integrating multiple goals of various brain projects together, the IBI serves as meta-middleman to promote coordination, share resources, and help unite different ideas on the future of neuroscience.

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'It takes a world': Initiative urges global collaboration to help us understand the human brain - Genetic Literacy Project

BioXcel Therapeutics Announces FDA Clearance of IND Application for BXCL501 for the Treatment of Opioid Withdrawal SymptomsCompany is preparing to…

NEW HAVEN, Conn., Feb. 05, 2020 (GLOBE NEWSWIRE) -- BioXcel Therapeutics, Inc. (BTI or Company) (Nasdaq: BTAI), a clinical-stage biopharmaceutical company utilizing artificial intelligence approaches to identify and advance the next wave of medicines in neuroscience and immuno-oncology, today announced that its Investigational New Drug (IND) application for BXCL501, the Companys proprietary sublingual thin-film formulation of dexmedetomidine (Dex), has received clearance from the U.S. Food and Drug Administration (FDA) for the treatment of opioid withdrawal symptoms.

The FDA clearance of our IND application for opioid withdrawal, a fourth indication, is an important step in our plans to build a neuroscience franchise around the multiple therapeutic opportunities with BXCL501, commented Vimal Mehta, Chief Executive Officer of BTI. Opioid overdose is reported as the number one cause of death for those under 50 years old in the U.S., and the distressing and challenging symptoms that come with opioid withdrawal are a primary reason for relapse. There is an urgent need for better treatment options to help manage the debilitating withdrawal symptoms and aid this underserved population from continued opioid abuse. BXCL501, our investigational non-opioid therapy, may offer key advantages to treating symptoms due to its intrinsic potency and favorable delivery method. We believe this study will build on the encouraging results we observed in our intravenous (IV) Dex trial, which appeared effective in reducing opioid withdrawal symptoms.

Opioid withdrawal is an emotional and physiological medical condition that may be driven by the excessive drive of noradrenergic neurons that originate from the locus coeruleus in the brainstem. BXCL501 selectively activates alpha-2a adrenergic receptors, which decreases excessive neuronal firing, alleviating the physiological symptoms of opioid withdrawal.

The RELEASE trial is a multicenter, randomized, double-blind, placebo-controlled, ascending-dose Phase 1b/2 study designed to evaluate the safety, pharmacokinetics, tolerability and efficacy of BXCL501 in patients experiencing symptoms of opioid withdrawal. This study will enroll subjects with opioid use disorder who are physically dependent on opioids. Patients will be randomized into multiple dose cohorts of BXCL501, or matching placebo, administered twice daily for five days. The study will assess opioid withdrawal symptoms using both the Clinical Opiate Withdrawal Scale and Short Opiate Withdrawal Scale of Gossop over a 10-day period.

About BXCL501BXCL501 is a potential first-in-class, proprietary sublingual thin film of dexmedetomidine, a selective alpha-2a receptor agonist for the treatment of acute agitation. BTI believes that BXCL501 directly targets a causal agitation mechanism and the Company has observed anti-agitation effects in multiple clinical studies across multiple neuropsychiatric indications. BXCL501 has also been granted Fast Track Designation by the U.S. Food and Drug Administration for the acute treatment of agitation.

A Phase 1b safety and efficacy study of BXCL501 yielded positive dose-response data. BXCL501 is being evaluated in the SERENITY program, consisting of two Phase 3 studies for the acute treatment of agitation in patients with schizophrenia (SERENITY I) and bipolar disorder (SERENITY II). BXCL501 is also being evaluated in a Phase 1b/2 trial for the treatment of agitation associated with dementia, and the Company is preparing to initiate the Phase 1b/2 RELEASE trial of BXCL501 for the treatment of opioid withdrawal symptoms.

About Opioid Drug Withdrawal:

According to the Centers for Disease Control and Prevention (CDC), the misuse of and addiction to opioids is a serious national crisis and is the leading cause of death in the U.S. for those under 50 years old. Between 1999-2017, almost 400,000 people died from an overdose involving an opioid, with greater than 47,000 deaths occurring in 2017 alone. The CDC estimates the total "economic burden" of prescription opioid misuse alone in the U.S. is $78.5 billion a year, including the costs of healthcare, lost productivity, addiction treatment and criminal justice involvement. Opioid withdrawal is a condition characterized by symptoms such as anxiety, agitation, sleep problems, muscle aches, runny nose, sweating, nausea, vomiting, diarrhea and drug craving that occur after stopping or reducing the use of opioids in anyone with physical dependence on opioids.

About BioXcel Therapeutics, Inc.BioXcel Therapeutics, Inc. is a clinical stage biopharmaceutical company utilizing artificial intelligence to identify improved therapies in neuroscience and immuno-oncology. BTI's drug re-innovation approach leverages existing approved drugs and/or clinically validated product candidates together with big data and proprietary machine learning algorithms to identify new therapeutic indices. BTI's two most advanced clinical development programs are BXCL501, a sublingual thin film formulation designed for acute treatment of agitation resulting from neuropsychiatric disorders, and BXCL701, an orally administered systemic innate immunity activator designed for treatment of a rare form of prostate cancer, pancreatic cancer and advanced solid cancers in combination with other immuno-oncology agents. For more information, please visit http://www.bioxceltherapeutics.com/.

Forward-Looking StatementsThis press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements in this press release include but are not limited to the effects of BXCL501 treatment on opioid withdrawal symptoms and the timing of clinical development initiatives and trials for BXCL501. When used herein, words including anticipate, being, will, plan, may, continue, and similar expressions are intended to identify forward-looking statements. In addition, any statements or information that refer to expectations, beliefs, plans, projections, objectives, performance or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking. All forward-looking statements are based upon BTI's current expectations and various assumptions. BTI believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. BTI may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important factors, including, without limitation, its limited operating history; its incurrence of significant losses; its need for substantial additional funding and ability to raise capital when needed; its limited experience in drug discovery and drug development; its dependence on the success and commercialization of BXCL501 and BXCL701 and other product candidates; the failure of preliminary data from its clinical studies to predict final study results; failure of its early clinical studies or preclinical studies to predict future clinical studies; its ability to receive regulatory approval for its product candidates; its ability to enroll patients in its clinical trials; its approach to the discovery and development of product candidates based on EvolverAI is novel and unproven; its exposure to patent infringement lawsuits; its ability to comply with the extensive regulations applicable to it; its ability to commercialize its product candidates; and the other important factors discussed under the caption Risk Factors in its Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2019, as such factors may be updated from time to time in its other filings with the SEC, which are accessible on the SECs website at http://www.sec.gov and on the Companys website at http://www.bioxceltherapeutics.com.

These and other important factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent managements estimates as of the date of this press release. While BTI may elect to update such forward-looking statements at some point in the future, except as required by law, it disclaims any obligation to do so, even if subsequent events cause our views to change. These forward-looking statements should not be relied upon as representing BTIs views as of any date subsequent to the date of this press release.

BioXcel Therapeutics, Inc.www.bioxceltherapeutics.com

Investor Relations:John Grazianojgraziano@troutgroup.com1.646.378.2942

Media:Julia Deutschjdeutsch@troutgroup.com1.646.378.2967

Source: BioXcel Therapeutics, Inc.

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BioXcel Therapeutics Announces FDA Clearance of IND Application for BXCL501 for the Treatment of Opioid Withdrawal SymptomsCompany is preparing to...

Neuroscience Market Application 2020- Industry Overview, Global Trends, Market Analysis, CAGR Values and Country Level Demand To Forecast by 2026 -…

Neuroscience Market Overview

The Neuroscience Market report released and promoted by CMI draw out historical, existing, and forecast valuation of the Neuroscience industry till 2026. The report highlights the market essentials, opportunities, regional market, Emerging Growth Factors, market challenges, forecast and competitors joined with their market share. The fundamental purpose of Neuroscience Market report is to provide a appropriate and strategic analysis of the Neuroscience industry.

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The Market structure covers the value chain, player categories, product ranges, key players presence across products and end user segments of the market. The report also provides a snapshot of key competition, market trends with forecast over the next 5 years, anticipated growth rates and the principal factors driving and impacting growth market data and analytics are derived from a combination of primary and secondary sources.

The research process involved the study of various factors affecting the industry, including the government policy, market situation, competitive landscape, historical data, present trends in the market, technological innovation, upcoming technologies and the technical progress in related industry, and market risks, opportunities, market barriers, and challenges.

Top merchant analysis is one of the key component and is exceptionally helpful for each player to comprehend focused scene in the market. Major key companies present in Neuroscience market report are:Alpha Omega, Inc., GE Healthcare, Axion Biosystems, Inc., Siemens Healthineers, Blackrock Microsystems LLC, Femtonics Ltd., Intan Technologies, LaVision Biotec GmbH, Mediso Medical Imaging Systems, Neuralynx Inc., NeuroNexus Technologies, Inc., Newport Corporation, Plexon Inc., Noldus Information Technology, Scientifica Ltd., Sutter Instrument Corporation, Thomas Recording GmbH, and Trifoil Imaging Inc.

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Market Event Factors Analysis

Market driver

Increasing market invasion of new technolgies.

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Market challenge

Stringent regulatory challenges in Neuroscience applications.

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Rising demand for Neuroscience in market.

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New Light on the Genetic Relationship Between Three Mood Disorders – Technology Networks

Researchers shed new light on the genetic relationship between three mood disorders associated with depressionmajor depression and bipolar disorder types 1 and 2, in a newstudyin the journalBiological Psychiatry, published by Elsevier.

The clearest findings are a genetic distinction between type 1 bipolar and type 2 bipolar, and the greater similarity of type 2 bipolar to major depressive disorder, said first author Jonathan Coleman, PhD, a statistical geneticist and postdoctoral fellow in the lab of senior author Gerome Breen, PhD at the Institute of Psychiatry, Neuroscience, and Psychology at Kings College London, UK.

Both types of bipolar disorder used to be referred to as manic-depressive disorder. Mania is a behavioral state associated with behavioral activation, euphoric or irritable mood, reduced need for sleep, impulsive behavior, impaired judgement, racing disorganized thoughts, impulsive behaviors, and frequently strongly held false beliefs (delusions) or hallucinations. Bipolar disorder type 1 is associated with mania and depression, while bipolar 2 is predominately associated with depression marked by mild symptoms reminiscent of mania, called hypomania.

The insights came from several extremely large datasets analyzed together. For their meta-analysis, Coleman, Breen and their co-authors combined genome-wide association studies from three large datasets of people with major depression and bipolar disorder to evaluate shared and distinct molecular genetic associations. Most of the data came from the large international Psychiatric Genomics Consortium. Additional data came from the UK Biobank, a major health resource established by the Wellcome Trust, and the online genetic service platform, 23andMe.

There are significant racial and ethnic differences in the findings from genome-wide association studies (GWAS). The findings of this study pertain only to people of European ancestry and findings might be different in other groups.

The authors also report that the genetic risk for these disorders was predictive of other traits as well. For example, the genetic risk for bipolar disorder was correlated with more educational attainment, while the heritable risk for major depressive disorder was associated with less education.

In the mouse brain, the authors also mapped the genetic risk for these disorders on to particular brain cell types using a sophisticated analytic strategy building on the pattern of genes expressed. They implicated serotonin neurons in the risk for both depression and bipolar disorder, while bipolar disorder distinctively involved GABA and glutamate neurons (nerve cell types also implicated in schizophrenia).

We have long known that mood disorders are highly heterogeneous and the boundaries between types of mood disorders are often difficult to define clinically, said John Krystal, MD, editor ofBiological Psychiatry. This new study suggests that there are aspects of genetic risk, and presumably brain function, that link forms of mood disorders, but there are also distinctions that may shed light on subtypes of depression that may have important implications for treatment.

Ultimately, the researchers want to develop clinical tools to help predict if a first episode of depression is likely to persist as a disorder or progress into bipolar disorder. Genetic data wont ever replace clinical insight, but it might be a useful addition to clinical models, said Coleman.

Reference:Coleman et al. (2019). The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biological Psychiatry. DOI: 10.1016/j.biopsych.2019.10.015.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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New Light on the Genetic Relationship Between Three Mood Disorders - Technology Networks

How African ‘feng shui’ can shape the continent’s cities of the future – CNN

Written by Matthew Ponsford, CNN

When architect Mphethi Morojele began designing Freedom Park in Pretoria, South Africa, a 130-acre (52-hectare) memorial to lives lost in the struggle against the country's Apartheid regime, he took the unconventional step of handing over the plans to a group of spiritual healers.

Work began nearly two decades ago, at which point these healers gathered signals from the natural and supernatural realms to create a sort of "heat map or a spiritual map of the site,'' explained Morojele.

"It's almost like the Chinese would use Feng Shui, where they feel the energies of the site and decide that this element must go here, this element must go there," he continued. "Then you start to lay out your design based on that as a kind of brief."

Freedom Park, Pretoria Credit: Clive Hassall

Alongside Ghanaian-British architect David Adjaye and Burkina Faso-born Dibdo Francis Kr, Morojele's name was listed among "a generation poised to take on the ambitious projects that will define the architectural character and identities of rising Africa," in an New York Times article by Chika Okeke-Agulum, professor of art history at Princeton.

Morojele says it is a role he is glad to take on. During a telephone interview from his office in Johannesburg, he called for his peers to break down boundaries that still carve up the continent's architects along colonial lines, into Anglophone, Francophone, and other distinctions.

Mary Sibande re-imagines the story of South Africa's domestic workers

"Nowadays, there's a sufficient cohort of architects who have some relationship to the continent -- either having been trained here, or having lived here, or come from here -- who are beginning to question what it means to do architecture in Africa," he said.

The Hapo Museum Gallery, Freedom Park, Pretoria

For Morojele, the priorities he made when designing Freedom Park -- to respect the full sensory experience of the environment, including its spiritual content, and carefully construct community bonds through inviting diverse voices to input into the design process -- are key to constructing the African buildings and cities of the future.

Born in Lesotho, the mountainous nation enclaved inside South Africa's borders, Morojele has led Johannesburg-based MMA Design Studio since just months after the fall of Apartheid. In addition to Freedom Park, he has spearheaded other emblematic nation-building projects including designing the African Leadership Academy secondary school on the outskirts of Johannesburg, and South African embassies in Berlin and Addis Ababa.

The South African Embassy in Addis Ababa

Not confined to architecture and urban design, Morojele has been sought out for thought-leadership across design disciplines. In 2013 he was asked to help design the funeral of Nelson Mandela, which aimed to create a new tradition for how a leader of democratic South Africa would be laid to rest.

After Freedom Park, he again assembled spiritual leaders for input on another complex project, a market in Johannesburg where herbalists and healers sell "indigenous magic medicine," mostly herbs and plants, explained Morojele.

Long-forgotten family portrait sells at auction for $1.4 million

This complex project formalized the sale of products used by most South Africans, especially recent migrants from rural areas, which are sometimes frowned upon by city-dwellers and pushed to the margins of the city, he said. Creating a formal commercial space for traditional healers -- some are called inyangas or sangomas -- and the accompanying rituals, meant designing a new type of market that recognized which practitioners and which types of magic needed to be kept apart.

"I guess it's like any other client would brief you," he explained. "Only they work in the spiritual realm and then bring it back to brief us."

The process of working with spiritual workers is just one method Morojele has used to include often-excluded voices in the design process. He has also consulted diverse stakeholders -- members of the public, residents of townships and students at schools and academies -- incorporating users input into the design.

The Cradle of Humankind Visitor Centre, Maropeng, South Africa

The goal of greater inclusivity should be at the forefront for architects in South Africa and beyond, Morojele argued.

"I'd like to see architects focus on the way architecture creates social cohesion. In South Africa, architecture has always been used to separate. It had subtle mechanisms in buildings that were used to define who belongs where: which entrance you use, depending on your skin color, and things like that."

Morojele says architects and urban planners can -- and must -- reverse that historical process of division to repair fissures and create more equitable cities.

The African Leadership Academy Learning Commons in Johannesburg Credit: Tristan McLaren/Tristan McLaren

The unexpected art of Ghana's hand-painted movie posters

The African Leadership Academy Learning Commons in Johannesburg Credit: Tristan McLaren/Tristan McLaren

But the architect is distinguished in matching a hard-nosed focus on righting past wrongs of urban planning with a sensitive approach to planning. For example, he favors natural materials for heritage projects that draw on local animistic beliefs -- traditional beliefs that inanimate objects contain spiritual energy.

Vivid portraits shine light on Tahiti's 'third gender'

In Freedom Park, Morojele used natural materials to create a narrative of remembrance and hope. To do this he assembled boulders from South Africa's nine provinces -- having been ritually blessed in interfaith prayer sessions in the name of peace -- and even imported soil from across the world.

Stones in Isivivane, Freedom Park, are blessed in a ceremony

"It started off as a place that would offer symbolic restitution to people who lost their lives in the struggle for liberation," he said.

The Garden of Remembrance, a green belt surrounding the central memorial, contains earth from countries outside of South Africa where people had been stationed in exile and had died during the fight for liberation. "In a sense, the installation is given a certain spiritual energy because of the soil used that has come from different countries, which is now embedded into the monument or memorials," he said.

The Garden of Rememberance at Freedom Park, Pretoria

Morojoele is keen to now connect more analytic and spiritual approaches. As he plans for future commissions, he sees a path forward via neuroscience, and the ideas of "environmental psychology" developed by the likes of Finnish architect Juhani Pallasmaa, which hopes to explain how our natural and built surroundings affect our behavior and emotions.

"The advances in neuroscience nowadays can relate the environment to people's emotions and people's nervous system, how it responds to different environments," Morojoele said. "I'm interested in understanding the Western scientific basis of what indigenous knowledge systems were expounding."

Why being an African artist is so important today

This approach -- combining neuroscience with animism, and layering landmarks and urban infrastructure with emotional nuances -- makes clear Morojele vision.

"We need to go back to understanding ourselves as biological beings, less as intellectual beings, bringing in more senses," he said.

Both forward-facing and grounded in tradition, Morojele hopes that the city of the future is an environment where we can connect with our own nature, and commune with our surroundings. "A more sensual architecture," he explained. "And one that heightens your experience of the environment."

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How African 'feng shui' can shape the continent's cities of the future - CNN

Can’t Sleep or Think Clearly? Maybe the Culprit is Bacteria – UMass News and Media Relations

AMHERST, Mass. With a $1 million grant from the W. M. Keck Foundation, neuroscience researchers at Washington State University and the University of Massachusetts Amherst will explore whether variations in brain levels of bacterial fragments can account for lifes sleep/wake and 24-hour cycles, known as circadian rhythms.

The bacteria residing inside of you outnumber your own cells 10 to one and affect sleep, cognition, mood, brain temperature, appetite and many additional brain functions. Yet we lack an understanding of how they do it, says James Krueger, Regents Professor of Integrative Physiology and Neuroscience at the WSU College of Veterinary Medicine.

The sleep research is led by Krueger, and the circadian rhythm portion of the project is led by co-investigator Ilia Karatsoreos, who recently joined UMass Amherst from WSU as an associate professor of psychological and brain sciences.

At Karatsoreos Lab, researchers will use models of simulated jet lag, a way to disrupt our circadian (daily) rhythms. As anyone who has flown cross-country has likely experienced firsthand, disrupting these rhythms is associated with changes in sleep, cognition and even body temperature.

When jetlagged, many of the normal bodily functions are out of synchrony with each other. This is a consequence of altering circadian rhythms, Karatsoreos says. By looking for changes of bacterial products in the brain, we anticipate we will discover new approaches to treat jet lag, and possibly the desynchrony of physiological functions that occurs with old age.

The new grant builds on nearly 40 years of cutting-edge sleep research. In the early 1980s, Krueger isolated a sleep-promoting molecule from brains of sleep-deprived rabbits and from human urine. Its chemical structure was a muramyl peptide a building block component of bacterial cell walls.

At the time of the discovery, it was difficult to measure small amounts of muramyl peptides. Now, improved measurement technologies and the Keck Foundation funding will enable researchers to determine the brains muramyl peptide levels and whether they correlate with sleep-wake cycles or circadian rhythms.

Further, researchers will determine if sleep loss results in increased levels of muramyl peptides in the brain, a predicted result based on the 1980s investigations.

Another goal of the Keck-funded work will be to determine how brain muramyl peptides elicit sleep. Our minds are an outcome of a bacteria/human symbiosis, Krueger said. Expanding this concept by determination of how such disparate species talk to each other will transform our views of cognition, psychiatric disorders, consciousness including sleep, and our understanding of what it means to be human.

The late W. M. Keck, founder of the Superior Oil Company, established The W. M. Keck Foundation in 1954.The Foundations grant making is focused primarily on pioneering efforts in the areas of medical research, science and engineering, and undergraduate education.

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Can't Sleep or Think Clearly? Maybe the Culprit is Bacteria - UMass News and Media Relations

Global NEUROSCIENCE ANTIBODIES AND ASSAYS Market , Trends, Analysis, Opportunities, Share and Forecast 2019-2025 – Melanian News

The global neuroscience antibodies and assays market can be categorized based on product type, indication, technology, end-user, and region. On the basis of product type, the market can be divided into consumables and instruments. The consumable segment can be sub-divided into reagents (media & sera, stains & dyes, fixatives, buffers, solvents, probes, enzymes, proteins, and peptides), antibodies (primary antibodies, secondary antibodies, and assay. The instruments segment can be further categorized into microplate readers, immunoassay analyzers, and others.

Based on indication, the global neuroscience antibodies and assays market can be segmented into Alzheimers disease, Parkinsons disease, Multiple sclerosis (MS), prion disease, Amyotrophic lateral sclerosis (ALS), and others. According to Alzheimers disease International, 46.5 million people were estimated to be suffering from dementia in 2015The increasing automation of high-throughput screening and the availability of robust data management software tools, which enable researchers to develop systemic and process-oriented approaches toward neuroscience antibodies and assays techniques are some of the factors contributing to the growth of this segment.

Global NEUROSCIENCE ANTIBODIES AND ASSAYS Market valued approximately USD 2.1 billion in 2016 is anticipated to grow with a healthy growth rate of more than 10.3% over the forecast period 2019-2025.

To request a sample copy or view summary of this report, click the link below:

https://www.digitsnmarkets.com/sample/5594-global-neuroscience-antibodies-and-assays-market

The objective of the study is to define market sizes of different segments & countries in recent years and to forecast the values to the coming eight years. The report is designed to incorporate both qualitative and quantitative aspects of the industry within each of the regions and countries involved in the study. Furthermore, the report also caters the detailed information about the crucial aspects such as driving factors & challenges which will define the future growth of the market. Additionally, the report shall also incorporate available opportunities in micro markets for stakeholders to invest along with the detailed analysis of competitive landscape and product offerings of key players. The detailed segments and sub-segment of the market are explained below:

By Product

By Technology

By End User

Some of the key manufacturers involved in the market are. Thermo Fisher Scientific, Abcam, Bio-Rad, Merck KGAA, Cell Signaling Technology, Genscript, Rockland Immunochemicals. Bio Legend, Santa Cruz Biotechnology, Tecan, F. Hoffmann-La Roche, Siemens. Acquisitions and effective mergers are some of the strategies adopted by the key manufacturers. New product launches and continuous technological innovations are the key strategies adopted by the major players.

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Global NEUROSCIENCE ANTIBODIES AND ASSAYS Market , Trends, Analysis, Opportunities, Share and Forecast 2019-2025 - Melanian News

New Investigation into Abnormal Neuron Activity in Rett Syndrome – Technology Networks

The brain undergoes dramatic change during the first years of life. Its circuits readily rewire as an infant and then child encounters new sights and sounds, taking in the world and learning to understand it. As the child matures and key developmental periods pass, the brain becomes less malleable--but certain experiences create opportunities for parts of the adult brain to rewire and learn again.

New research by Billy Lau, a postdoctoral researcher working with Assistant Professor Keerthi Krishnan in the Department of Biochemistry and Cellular and Molecular Biology in the University of Tennessee, Knoxville's College of Arts and Sciences, examines the time during which an adult female mouse first learns to recognize and respond to the distress cries of young mouse pups as one such opportunity for rewiring.

The findings were published earlier this month in the Journal of Neuroscience and hint at potential therapeutic strategies for Rett syndrome, a rare neurodevelopmental disorder.

Krishnan's lab researches how mutated genes affect brain plasticity, ultimately leading to neurological diseases, specifically Rett syndrome. In humans, mutations in the gene MECP2 cause Rett syndrome. Children with Rett syndrome appear to develop normally for the first several months of life but later begin to lose language and motor skills.

"Children diagnosed with neurodevelopmental disorders eventually grow up and continue to exhibit symptoms throughout life," Krishnan said. "Though much research is focused on identifying and diagnosing neurodevelopmental disorders, much work needs to be done to help improve or manage symptoms for patients throughout their life. Rett syndrome mainly affects girls and women worldwide; very few studies focus on pathology of the disorder in adult women."

For several years, Lau and Krishnan have been conducting research with a team at Cold Spring Harbor Laboratory headed by Stephen Shea and Josh Huang. In their previous work, the team discovered that female mice lacking one functional copy of Mecp2 failed to respond to the distress cries of their young. The scientists honed in on the abnormal behavior of a group of neurons in the auditory cortex called parvalbumin (PV) neurons together with higher protein expression of perineuronal nets (PNNs), structures that improve connections within the brain.

"PVs and PNNs are thought to be inhibitory, acting as a brake in the brain that prevents learning," Lau said. "In the new study, we tested this hypothesis. Our findings reveal a physiological mechanism underlying the progression of Rett syndrome that may extend to other brain regions."

In the new study, Lau and the other members of the team took a closer look at how exposure to the young pups changes signaling within the auditory cortex of female mice. By monitoring the activity of individual cells in this part of the brain, the researchers found that when Mecp2 is intact, the dampening effect of PNNs and PV neurons decreases following exposure to the pups. This allows other neurons in the circuit to become more responsive to the young animals' cries. This change occurred even in mice that had never been pregnant. In female mice whose Mecp2 gene was impaired, however, the dampening signals remained strong.

The findings support previous evidence that the function of PV neurons is particularly vulnerable to the loss of Mecp2, suggesting that these cells or the circuits they are involved in may be appropriate targets for drug development and that patients with Rett syndrome may be most responsive to treatment during certain periods of life in conjunction with their environment and social experience.

"This work has implications in continuing to understand what roles Mecp2 plays in typical brain activity and function, especially in complex social situations, similar to what patients encounter in their daily lives," Krishnan said. "If we understand the mechanisms and roles of this protein in social communication and perception, we will be able to find ways to compensate for lack of this protein through therapeutic or rehabilitative treatments."

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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New Investigation into Abnormal Neuron Activity in Rett Syndrome - Technology Networks