Category Archives: Neuroscience

An Oregon nonprofit brings an actual brain, and brainpower to classrooms – KGW.com

PORTLAND, Ore. Getting the attention of middle school science students is a no-brainer for NW Noggin.

Students get a real hands-on experience, even holding a human brain, as the nonprofit teaches lessons in neuroscience.

We are all volunteers going into classrooms learning what kids are curious about. They ask so many questions, said NW Noggin founder Bill Griesar.

Since 2012, the nonprofit has reached 40,000 students.

On Tuesday, they visited Portlands Hosford Middle School bringing plastic models of brains, preserved sections of the brain and a real one to hold.

Its heavier than I thought it would be and squishy, recalled one student.

The program relies on graduate students from OHSU and PSU.

We bring these advanced students into classrooms so the kids can see the possibilities. Maybe they will want to follow a similar path someday, said Griesar.

NW Noggin has taken its program to other cities such as Chicago and Washington D.C.

This Saturday, March 7, theyll be at OMSIs Brain Fair.

Its really cool, one student said. This was a super fun day.

RELATED: KGW's Drew Carney explains the science behind Leap Year and Leap Day

RELATED: 'You have your life back': New brain surgery at OHSU controls debilitating tremor

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An Oregon nonprofit brings an actual brain, and brainpower to classrooms - KGW.com

The Hereditary Neuropathy Foundation’s Movement is Medicine(TM) Program Expands to Florida and Continues to Shed Light on the Impact Exercise Has on…

NEW YORK, March 3, 2020 /PRNewswire/ -- The Hereditary Neuropathy Foundation(HNF) Movement is Medicine is expanding across the US with its latest Summit announced for March 21, 2020 in Winter Park, Florida at the Center for Health and Wellbeing, which is a collaboration between the Winter Park Health Foundationand AdventHealth. The 80,000-square foot, state-of-the-art facility offers the best community health and wellness programs in Central Florida.

"The Neuromuscular Division of the AdventHealth Neuroscience Institute is overjoyed to partner with the Hereditary Neuropathy Foundation as a Center of Excellence. The HNF has established itself as an organization in which individuals with hereditary neuropathies-also known as CMT-come first. Our division echoes this goal of patients coming first. We are excited to host the Movement is Medicine program here in Orlando; this program will demonstrate not only how much exercise is necessary in hereditary neuropathies, but also how much fun exercise can be by forming new friendships and creating positive energy that can be healing in every way."

-Nivedita Jerath MD, MS Medical Director of Neuromuscular Medicine, AdventHealth

Sponsored by AdventHealth, this Movement is Medicine Summit will be free to attend and feature inspirational speakers, expert instructors and informational breakout sessions specifically curated by and for CMT patients.

Over 100 attendees are expected to participate, with children, caretakers and family members also welcome.

"HNF is thrilled to bring its groundbreaking Movement is Medicine program to Winter Park," said Allison Moore, Founder and CEO of HNF. "Our patient-centered approach to the treatment of CMT disease is aligned with the terrific work that Dr. Jerathand her team are doing at the AdventHealth Neuroscience Institute, and we couldn't be more excited to be holding our event at the Center for Health and Wellbeing.

Registerfor the Movement is Medicine Summit Orlando.

HNF is grateful for all who continue to help make these impactful Summits possible and who are making a difference in the lives of our courageous attendees.

The HNF team is also planning its annual 2-day Movement is Medicine Summit in Phoenix, AZ at Ability360 for November 13-14th, 2020.

About Hereditary Neuropathy Foundation (HNF)HNF, a non-profit 501(c) 3 organizationwhose mission is to increase awareness and accurate diagnosis of CMT and related inherited neuropathies, support patients and families with critical information to improve quality of life, and fund research that will lead to treatments and cures. HNF developed the Therapeutic Research in Accelerated Discovery (TRIAD) program, a collaborative effort with academia, government and industry, to develop treatments for CMT. Currently, TRIAD involves many groups that span the drug discovery, drug development and diagnostics continuum.

About AdventHealth's Central Florida Division:Founded in 1908 by pioneering Seventh-day Adventists who believed in whole-person health healing the body, mind and spirit AdventHealth has grown into one of the largest nonprofit hospitals in the country, caring for more than two million patient visits per year in metro Orlando alone. AdventHealth operates more than 50 hospitals and hundreds of care centers in nearly a dozen states, making it one of the largest faith-based health-care systems in the United States.

AdventHealth's Central Florida Division encompasses 20 hospitals in the seven counties in and surrounding metro Orlando: Orange, Seminole, Osceola, Polk, Lake, Volusia and Flagler. The Central Florida Division's care network also includes more than 30 Centra Care urgent-care centers; dozens of sports-rehab and imaging centers; and hundreds of physicians, ranging from primary care to a full spectrum of specialties.

AdventHealth Orlando, the division's flagship campus, serves both as a community hospital and as a major tertiary referral hospital for the region, much of the Southeast, the Caribbean and Latin America.

AdventHealth Orlando is a designated statutory teaching hospital and trains physicians from around the world on the newest technology and procedures. The system provides a wide range of health services, including many nationally and internationally recognized programs in cardiology, cancer, women's medicine, neuroscience, diabetes, orthopedics, pediatrics, transplant and advanced surgical programs.

The AdventHealth Research Institute has more than 250 investigators and more than 500 clinical trials in progress. AdventHealth Orlando is also home to the Translational Research Institute for Metabolism & Diabetes and the Nicholson Center for Surgical Advancement.

Contact: Allison MooreT: 1-855-HELPCMT (435-7268)E: allison@hnf-cure.org

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Alumnus builds coffee business from the ground up – The Rider News

Mark Maslanka 18 started brewing up his own coffee business while studying neuroscience at Rider. He eventually moved to Colorado where his business took off.

by Cassandra Stathis

Early in the day, it is common to hear someone say Dont talk to me till Ive had my morning coffee. It is the best part of the day for many hardworking students and employees. But what exactly is the science behind coffee?

Rider alumnus Mark Maslanka 18 is very familiar with the process behind the caffeinated beverage, as he is the proud owner of his own coffee company, named Science of Coffee.

Maslanka had a long history with coffee, even before college.

Coffee was always something that brought me relaxation, he said. And made me feel like one of the adults.

Maslankas allure to the drink was the root of inspiration behind his company.

The quality of coffee I produce today just blows me away, Maslanka said. It brings me right back to those first couple sips when I was a kid in the car with my dad.

Maslanka planned to just experiment with his favorite drink in order to perfect his recipe.

I mastered different methods from around the world in trying to produce the best tasting cup of coffee, he said.

Todd Weber, a professor of biology at Rider, had Maslanka in a past neuroscience class, and admired his work ethic when he was a student.

Mark [Maslanka] had a pragmatic approach to getting work done when it needed to be done, said Weber.

Before Maslanka left Rider, he decided to leave one last gift with his professors. It was something from the heart that he believed they would appreciate.

Mark [Maslanka] graced me with some of his coffee before he graduated. [It was] very fragrant, so much better than much of the coffee we get around here, Weber said.

Neuroscience and coffee may not seem like they have a lot in common, but Weber disagreed.

I think its very cool that Mark was able to meld his behavioral neuroscience background with a spirit of entrepreneurship to start a company around the most widely used neuroactive substance on the planet, caffeine, Weber said. Hes an ultimate scientific entrepreneur.

Maslanka had never expected his business to take off so quickly, so the success of his business came as a surprise to him.

I didnt think Id be selling coffee to people across the country, I only started this as an excuse to roast more coffee than I could drink, he said. Im just along for the ride, waiting to see where itll take me next. Everything up until this point has been purely from word of mouth besides the occasional stranger that stumbles upon my website. Thats how you know its good coffee.

Maslankas company also sells photographs of nature and wildlife that he has taken.

Its my way of showing others what untouched nature looks like deep in the wilderness. I love being able to remind people why its worth trying so hard to conserve these creatures, he said.

The Rider alumnus credits his business website with helping him get off the ground.

My site has given me a large boost in credibility in life, with a very physical example of how hard I work on things I am interested in, he said. It also got me into my current position where I am today.

Maslanka went on to discuss how coffee fits in with his work, describing the effects that different coffee beans have on the body.

One of the side projects I inherited is a coffee-omics study, investigating metabolomic differences between different coffees grown around the world, he said.

During the hours he works strictly with coffee, he is sourcing new beans in small batches from farms around the world and optimizing a roasting profile to enhance the development of the natural flavors unique to that origin.

Science of Coffee is the perfect blend of Maslankas passions, balancing neuroscience and the environment in one successful business.

Published in the 3/4/20 edition

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Alumnus builds coffee business from the ground up - The Rider News

Neuroscience: Overview, history, major branches

Neuroscientists focus on the brain and its impact on behavior and cognitive functions, or how people think.

They also investigate what happens to the nervous system when people have neurological, psychiatric, and neurodevelopmental disorders.

A neuroscientist can specialize in a wide range of fields, from neuroanatomy to neuropsychology. Research in this field can improve our understanding of both the brain and the body, how they work, and the health issues that affect them.

Neuroscience is an interdisciplinary science that works closely with other disciplines, such as mathematics, linguistics, engineering, computer science, chemistry, philosophy, psychology, and medicine.

Neuroscientists study the cellular, functional, behavioral, evolutionary, computational, molecular, cellular, and medical aspects of the nervous system. There are various fields that focus on different aspects, but they often overlap.

Researchers might look into brain activity in people with ailments such as Alzheimers disease. Tools used include MRI scans and computerized 3-D models. They may do experiments using cell and tissue samples.

The findings may lead to the development of new medications. Some neuroscientists are involved in treating patients.

Neuroscience affects many, if not all, human functions, but it also contributes to a better understanding of a wide range of common conditions.

These include:

A greater understanding of neurological factors can help in developing medications and other strategies to treat and prevent these and many other health issues.

The ancient Egyptians thought the seat of intelligence was in the heart. Because of this belief, during the mummification process, they would remove the brain but leave the heart in the body.

The ancient Greeks were among the first people to study the brain. They attempted to understand the role of the brain and how it worked and to explain neural disorders.

According to an article in Scientific American, Aristotle, the Greek philosopher, had a theory that the brain was a blood-cooling mechanism.

Pierre Paul Broca (1824-1880) was a French physician, surgeon, and anatomist. He worked with patients who had brain damage. He concluded that different regions in the brain were involved in specific functions.

The part of the brain known as Brocas area is responsible for some speech and other functions. Damage to this area during a stroke can lead to Brocas aphasia, when a person can no longer produce accurate or coherent speech.

In the 19th century, von Hemholtz, a German physician and physicist, measured the speed at which nerve cells produced electrical impulses.

During 1873, Gamillo Golgi, an Italian physician, pathologist, and scientist, used silver chromate salt to see what neurons looked like.

Early in the 20th century, Santiago Ramn y Cajal, a Spanish pathologist, histologist, and neuroscientist, hypothesized that the neurons are independent nerve cell units.

In 1906, Golgi and Cajal jointly received the Nobel Prize in Physiology or Medicine for their work and categorization of neurons in the brain.

Since the 1950s, research and practice in modern neurology have made great strides, leading to developments in the treatment of stroke, cardiovascular disease, multiple sclerosis (MS) and other conditions.

Scientific developments have enabled neuroscientists to study the nervous systems structure, functions, development, abnormalities, and ways it can be altered.

Some major branches of neuroscience can be broadly categorized in the following disciplines:

Affective neuroscience: Research looks at how neurons behave in relation to emotions.

Behavioral neuroscience: This is the study of how the brain affects behavior.

Clinical neuroscience: Medical specialists, such as neurologists and psychiatrists, look at the disorders of the nervous system from basic neuroscience findings to find ways to treat and prevent them. They also look for ways to rehabilitate those who have undergone neurological damage. Clinical neuroscientists consider mental illnesses as brain disorders.

Cognitive neuroscience: This looks at how the brain forms and controls thoughts, and the neural factors that underlie those processes. During research, scientists measure brain activity while people carry out tasks. This field combines neuroscience with the cognitive sciences of psychology and psychiatry.

Computational neuroscience: Scientists try to understand how brains compute. They use computers to simulate and model brain functions, and applying techniques from mathematics, physics, and other computational fields to study brain function.

Cultural neuroscience: This field looks at the interaction between cultural factors and are genomic, neural, and psychological processes. It is a new discipline that may help explain variations in health measures between different populations. Findings may also help scientists to avoid cultural bias when designing experiments.

Developmental neuroscience: This looks at how the brain and the nervous system grow and change, from conception through adulthood. Information gathered helps scientists understand more about how the neurological systems develop and evolve. It enables them to describe and understand a range of developmental disorders. It also offers clues about how and when neurological tissues regenerate.

Molecular and cellular neuroscience: Scientists look at the role of individual molecules, genes, and proteins in the functioning of nerves and the nervous system at a molecular and cellular level.

Neuroengineering: Researchers use engineering techniques to better understand, replace, repair, or improve neural systems.

Neuroimaging: This is a branch of medical imaging that concentrates on the brain. Neuroimaging is used to diagnose disease and assess the health of the brain. It can also be useful in the study of the brain, how it works, and how different activities affect the brain.

Neuroinformatics: This field involves collaboration between computer scientists and neuroscientists. Experts develop effective ways to collect, analyze, share, and publish data.

Neurolinguistics: Specialists investigate how the brain enables us to acquire, store, understand, and express language. It helps speech therapists develop strategies to help children with speech difficulties or people who wish to regain their speech after, for example, a stroke.

Neurophysiology: This looks at how the brain and its functions relate to different parts of the body, and the role of the nervous system, from the subcellular level to whole organs. It helps scientists understand how human thought works and provides insight into disorders relating to the nervous system.

Neuroscience is a new and important field with implications for every aspect of how people move, think, and behave. In 2007, it was estimated that abnormal neurological conditions were thought to affect up to 1 billion people worldwide.

People who join this profession need to have an interest in science and math. Most neuroscientists start out by completing a bachelors degree in neuroscience before then pursuing a PhD.

Those who wish to do clinical work and treat patients must also train first as a Medical Doctor (MD) and complete a medical residency. They must also pass the United States Medical Licensing Examination.

They may then take a postdoctoral fellowship, for example, in a lab, to get further training before applying for a job.

According to the United States Bureau of Labor Statistics, the median annual salary of a medical scientist, including neuroscientists, in 2016 was $80,530. Salaries ranged from a low of $57,000 to a high of $116,840.

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Neuroscience: Overview, history, major branches

Immersion Neuroscience Reveals What Folks Really Love with a Little Help From PR Mavens at Bob Gold & Associates – Broadcasting & Cable

Immersion Neuroscience, the worlds most advanced predictive software company unlocking neuroscience to measure what people love, has selected Bob Gold & Associates, a nationally recognized boutique public relations and marketing agency, as its public relations agency of record to help launch its new cloud-based audience prediction platform. The Immersion platform helps companies identify, quantify and predict what live or taped events, training, and entertainment motivate audiences to action so that companies can significantly improve their ability to connect with consumers and increase ROI.

"With more than two decades of research, weve developed an entirely new way to understand how the brain values content, and how to predict what content will drive actions with high accuracy," said Paul J. Zak, Ph.D., Founder of Immersion. We coined the term immersion to denote a measurable neurologic state, and today, Immersion offers an easy to use and powerful tool that allows any company to analyze content and predict how audiences will respond. And it doesn't take a neuroscientist to know that Bob Gold & Associates, with their unparalleled expertise and a proven track record, is the right company to help get our story told.

Immersions proprietary solution and software is the world's most accurate way to measure the brain's unconscious emotional responses to virtually any type of content whether its video, music, live events, training, educational resources and more. Developed by distinguished research scientists, Immersions simple to use and scalable predictive SaaS platform democratizes neuroscience so that anyone can measure what people love at scale.

Life doesnt happen inside a lab, Zak added. Until now, companies could only measure what people in the real world said they liked not how their brains were truly valuing an experience. Immersion is able to measure what folks truly, viscerally love, anywhere, anytime and in real time.

The Immersion platform infers when the brain values an experience in real-time with a small wearable sensor that can be used anywhere. Unlike traditional neuroscience technologies that use expensive, immobile and delicate lab equipment and require highly trained professionals to collect and analyze the data, Immersion takes multiple measures of brain activity and puts them into an easy to understand 0-10 measure collected every second. Immersions clients use the platform anywhere, anytime and at scale, empowering companies to predict future behavior and market outcomes with 90% or better accuracy.

"Immersion is a revolutionary company. With their unique cloud-based solution, measuring brain activity is no longer confined to a laboratory with expensive instruments," said Bob Gold, CEO of Bob Gold & Associates. "There are billions of dollars being spent in original programming, half of which never connects with audiences. Today for every network and streaming service, hits are everything. Immersion has proven, with peer-reviewed publications and blinded studies, its ability to identify hit shows, movies, songs and so much more.

Because its built in the cloud, and not in a lab, Immersions software is portable and effortlessly scalable, enabling clients to leverage the power of neuroscience on the fly, anywhere in the world. And while other companies can take months to compile results, Immersions software provides an immediate assessment, unlocking the power of neuroscience for anyone without the need for extensive training.

In one study, for example, two measures from the platform peak immersion, and frustration were enough to predict the top-rated unscripted TV shows with 84% accuracy.

Many leading global brands are already utilizing Immersion in countless ways. This includes shaping content and business decisions by predicting hit TV shows and movies, chart-topping songs, sales bumps, TV ratings, viral content, what has the highest impact at live events, and even HR and corporate training, all by accurately identifying what is truly valued by audience members brains.

For more about Bob Gold & Associates, visit http://www.bobgoldpr.com.

To learn more about Immersion, visit http://www.getimmersion.com.

For more information, contact:

Bob Gold & Associates

310-320-2010

immersion@bobgoldpr.com

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Immersion Neuroscience Reveals What Folks Really Love with a Little Help From PR Mavens at Bob Gold & Associates - Broadcasting & Cable

Duck flies to Capitol Hill as one of top undergrad researchers in U.S. – AroundtheO

Research matters, and scientists can do more to make their important work accessible to the public. Those are the messages UO biology major Rennie Kendrick takes to Congress this April.

The Stamps Scholar from Portland was chosen among 60 of the nations top undergraduate researchers to participate in Posters on the Hill, a Washington, D.C. event showcasing innovative student work and demonstrating the value of federal investments in undergraduate research.

Its exciting, said the Clark Honors College senior. It will be great for members of Congress to see whats happening at the undergraduate level. Its important to fund and encourage this research, because discoveries have been made by undergraduates important discoveries.

Sponsored by the Council on Undergraduate Research, the annual event highlights student research for members of Congress, congressional staffers and federal government officials. A national panel of experts in their respective fields selects the finalists, and Kendrick is the second UO student to attend since the university joined the council in 2014.

The Undergraduate Research Opportunity Program and Vice President for Research and Innovation are helping fund her trip.

Kendrick will be presenting a poster on memory and innovative thinking, the subject of her honors thesis. Her plans include meeting with members of Oregons congressional delegation. Assistant professor Dasa Zeithamova-Demircan is helping Kendrick with the project, part of their work in the UOs Brain and Memory Lab.

The research is novel and complex. But Kendrick is planning a straightforward presentation.

There seems to be a growing misunderstanding about science for the general public, as well as the politicians who make decisions and allocate resources, she said. As scientists, we need to be able to communicate.

Kendricks fascination with science started early. After learning about birds in the third grade, she wanted to be an ornithologist. For Christmas, shed ask for research-related gifts, such as her treasured weather measurement kit.

Kendrick first learned about neuroscience while preparing for the eighth-grade science fair. She started her project on memory the summer before school had even started, submitting her idea to the Institutional Review Board so she could conduct experiments with people.

When youre an eighth-grader, you cant do much with human subjects, she recalled. But I got my approval. And I checked out every neuroscience book they had at the library. I just could not get enough of it. I knew about psychology and biology, then they fused together in my mind. I realized there was an entire biology to how we memorize things and have memories. That blew my mind. From then on, I have wanted to be a neuroscientist.

Kendrick excelled at Portlands Grant High School, where she ran track and cross country, participated in the state championship cross country team, was part of the 2016 state girls 6A champion 4x400 meter relay squad and qualified for state in the 1,500- and 3,000-meter events. She also served as managing editor of Grant Magazine, participated in Grants award-winning Constitution Team which has competed in the We the People national finals sang in the Royal Blues chamber choir, and volunteered in a behavioral neuroscience lab at Oregon Health and Science University-Portland Veterans Affairs Medical Center, where she was a 2017 Portland Veterans Affairs research fellow.

She chose the UO because she was offered a Stamps Scholarship, the universitys most prestigious and generous scholarship. Granted by the UO and the Strive Foundation, it is awarded to just 10 incoming freshmen each year, five residents and five nonresidents.

Kendrick joined the UOs track and cross-country teams as a walk-on during her first year and continued until injuries ongoing stress fractures that sporadically kept her from competing forced her to step down this year.

Those were tough lessons, she said. You put so much time into something and tomorrow you could be on crutches. Thats a good analogy for research, because you can put years into a project and find that its a null result. You have to be OK with saddling up again and putting effort into something, even if you know it could all go wrong at the drop of a hat. Its a nonlinear progression sometimes, but you have to keep in mind you are still making progress.

Over the years, Kendrick has been able to participate in research opportunities and make the most of her undergraduate experience thanks to support from UO organizations such as the Undergraduate Research Opportunity Program, the Office of the Vice President for Research and Innovation, the Center for Undergraduate Research and Engagement and the Office of Distinguished Scholarships.

Kendrick and another student are collaborating with professor Alice Barkan on a genetics research project and Kendrick was a 2019 Peter ODay Research Fellow. She currently works in the UOs Brain and Memory Lab, as well as the McCormick Lab at the Institute of Neuroscience. She also teaches a supplemental instruction course for business calculus and tutors students in biology, math and chemistry.

After graduating this spring, Kendrick heads to the University of British Columbia, where shell be working in a lab studying mechanisms of fear memory formation. She hopes to someday join the faculty at a college or university, combining her top three interests: research, teaching and writing.

By Ed Dorsch, University Communications

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Duck flies to Capitol Hill as one of top undergrad researchers in U.S. - AroundtheO

Too Much Excitation: The Neural Basis of Sensory Hypersensitivity – Technology Networks

Many people with autism spectrum disorders are highly sensitive to light, noise, and other sensory input. A new study in mice reveals a neural circuit that appears to underlie this hypersensitivity, offering a possible strategy for developing new treatments.MIT and Brown University neuroscientists found that mice lacking a protein called Shank3, which has been previously linked with autism, were more sensitive to a touch on their whiskers than genetically normal mice. These Shank3-deficient mice also had overactive excitatory neurons in a region of the brain called the somatosensory cortex, which the researchers believe accounts for their over-reactivity.

There are currently no treatments for sensory hypersensitivity, but the researchers believe that uncovering the cellular basis of this sensitivity may help scientists to develop potential treatments.

We hope our studies can point us to the right direction for the next generation of treatment development, says Guoping Feng, the James W. and Patricia Poitras Professor of Neuroscience at MIT and a member of MITs McGovern Institute for Brain Research.

Feng and Christopher Moore, a professor of neuroscience at Brown University, are the senior authors of the paper. McGovern Institute research scientist Qian Chen and Brown postdoc Christopher Deister are the lead authors of the study.Too much excitationThe Shank3 protein is important for the function of synapses connections that allow neurons to communicate with each other. Feng has previously shown that mice lacking the Shank3 gene display many traits associated with autism, including avoidance of social interaction, and compulsive, repetitive behavior.

In the new study, Feng and his colleagues set out to study whether these mice also show sensory hypersensitivity. For mice, one of the most important sources of sensory input is the whiskers, which help them to navigate and to maintain their balance, among other functions.

The researchers developed a way to measure the mices sensitivity to slight deflections of their whiskers, and then trained the mutant Shank3 mice and normal (wild-type) mice to display behaviors that signaled when they felt a touch to their whiskers. They found that mice that were missing Shank3 accurately reported very slight deflections that were not noticed by the normal mice.

They are very sensitive to weak sensory input, which barely can be detected by wild-type mice, Feng says. That is a direct indication that they have sensory over-reactivity.

Once they had established that the mutant mice experienced sensory hypersensitivity, the researchers set out to analyze the underlying neural activity. To do that, they used an imaging technique that can measure calcium levels, which indicate neural activity, in specific cell types.

They found that when the mices whiskers were touched, excitatory neurons in the somatosensory cortex were overactive. This was somewhat surprising because when Shank3 is missing, synaptic activity should drop. That led the researchers to hypothesize that the root of the problem was low levels of Shank3 in the inhibitory neurons that normally turn down the activity of excitatory neurons. Under that hypothesis, diminishing those inhibitory neurons activity would allow excitatory neurons to go unchecked, leading to sensory hypersensitivity.

To test this idea, the researchers genetically engineered mice so that they could turn off Shank3 expression exclusively in inhibitory neurons of the somatosensory cortex. As they had suspected, they found that in these mice, excitatory neurons were overactive, even though those neurons had normal levels of Shank3.

If you only delete Shank3 in the inhibitory neurons in the somatosensory cortex, and the rest of the brain and the body is normal, you see a similar phenomenon where you have hyperactive excitatory neurons and increased sensory sensitivity in these mice, Feng says.Reversing hypersensitivityThe results suggest that reestablishing normal levels of neuron activity could reverse this kind of hypersensitivity, Feng says.

That gives us a cellular target for how in the future we could potentially modulate the inhibitory neuron activity level, which might be beneficial to correct this sensory abnormality, he says.

Many other studies in mice have linked defects in inhibitory neurons to neurological disorders, including Fragile X syndrome and Rett syndrome, as well as autism.

Our study is one of several that provide a direct and causative link between inhibitory defects and sensory abnormality, in this model at least, Feng says. It provides further evidence to support inhibitory neuron defects as one of the key mechanisms in models of autism spectrum disorders.

He now plans to study the timing of when these impairments arise during an animals development, which could help to guide the development of possible treatments. There are existing drugs that can turn down excitatory neurons, but these drugs have a sedative effect if used throughout the brain, so more targeted treatments could be a better option, Feng says.

We dont have a clear target yet, but we have a clear cellular phenomenon to help guide us, he says. We are still far away from developing a treatment, but were happy that we have identified defects that point in which direction we should go.ReferenceThijssen et al. (2020) Diagnostic value of plasma phosphorylated tau181 in Alzheimers disease and frontotemporal lobar degeneration. Nature Medicine. DOI: https://doi.org/10.1038/s41591-020-0762-2

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Too Much Excitation: The Neural Basis of Sensory Hypersensitivity - Technology Networks

Vice Provost Nathan Urban to take position at Lehigh – University of Pittsburgh The Pitt News

Nathan Urban will leave his position as vice provost for Pitts graduate studies and strategic initiatives this summer to become the provost of Lehigh University.

According to a statement released by Provost and Senior Vice Chancellor Ann Cudd, details regarding the search for his successor will be announced in the coming weeks.

Urban started working in the Office of the Provost in 2015 as a vice provost for special projects and later became vice provost for graduate studies and strategic initiatives in 2017. He has also served as a professor and associate chair of the department of neurobiology, the associate director of the Brain Institute and co-director of the Center for the Neural Basis of Cognition.

During his time as vice provost for graduate studies and strategic initiatives, Urban established several programs in order to bring graduate students across the University closer together such as monthly newsletters, social media platforms, events and office hours. He also started the graduate studies retreat a daylong event that brings together administrators, faculty and students from 14 of Pitts graduate and professional schools. More recently, Urban served as a co-chair of the Plan for Pitt 2025 committee.

According to the statement, he is also regularly involved with the Postdoctoral Association and has assisted members in promoting resources from across the University to postdoctoral students.

Urban is also a Pitt alum and received a bachelors of science in neuroscience, math and philosophy and a Ph.D. in neuroscience from the University.

Urban worked for Carnegie Mellon from 2002 to 2015 before coming to Pitt. He began as a professor in the biological sciences department after completing a postdoctoral fellowship at the Max Planck Institute for Medical Research in Heidelberg, Germany. He later became the Frederick Schwertz Distinguished Professor of Life Sciences and head of the biological sciences department from 2010 to 2014. Urban served as CMUs interim provost from 2014 to 2015.

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Vice Provost Nathan Urban to take position at Lehigh - University of Pittsburgh The Pitt News

The Hereditary Neuropathy Foundation’s Movement is Medicine Program Expands to Florida and Continues to Shed Light on the Impact Exercise Has on…

NEW YORK, March 3, 2020 /PRNewswire/ -- The Hereditary Neuropathy Foundation(HNF) Movement is Medicine is expanding across the US with its latest Summit announced for March 21, 2020 in Winter Park, Florida at the Center for Health and Wellbeing, which is a collaboration between the Winter Park Health Foundationand AdventHealth. The 80,000-square foot, state-of-the-art facility offers the best community health and wellness programs in Central Florida.

"The Neuromuscular Division of the AdventHealth Neuroscience Institute is overjoyed to partner with the Hereditary Neuropathy Foundation as a Center of Excellence. The HNF has established itself as an organization in which individuals with hereditary neuropathies-also known as CMT-come first. Our division echoes this goal of patients coming first. We are excited to host the Movement is Medicine program here in Orlando; this program will demonstrate not only how much exercise is necessary in hereditary neuropathies, but also how much fun exercise can be by forming new friendships and creating positive energy that can be healing in every way."

-Nivedita Jerath MD, MS Medical Director of Neuromuscular Medicine, AdventHealth

Sponsored by AdventHealth, this Movement is Medicine Summit will be free to attend and feature inspirational speakers, expert instructors and informational breakout sessions specifically curated by and for CMT patients.

Over 100 attendees are expected to participate, with children, caretakers and family members also welcome.

"HNF is thrilled to bring its groundbreaking Movement is Medicine program to Winter Park," said Allison Moore, Founder and CEO of HNF. "Our patient-centered approach to the treatment of CMT disease is aligned with the terrific work that Dr. Jerathand her team are doing at the AdventHealth Neuroscience Institute, and we couldn't be more excited to be holding our event at the Center for Health and Wellbeing.

Registerfor the Movement is Medicine Summit Orlando.

HNF is grateful for all who continue to help make these impactful Summits possible and who are making a difference in the lives of our courageous attendees.

The HNF team is also planning its annual 2-day Movement is Medicine Summit in Phoenix, AZ at Ability360 for November 13-14th, 2020.

About Hereditary Neuropathy Foundation (HNF)HNF, a non-profit 501(c) 3 organizationwhose mission is to increase awareness and accurate diagnosis of CMT and related inherited neuropathies, support patients and families with critical information to improve quality of life, and fund research that will lead to treatments and cures. HNF developed the Therapeutic Research in Accelerated Discovery (TRIAD) program, a collaborative effort with academia, government and industry, to develop treatments for CMT. Currently, TRIAD involves many groups that span the drug discovery, drug development and diagnostics continuum.

About AdventHealth's Central Florida Division:Founded in 1908 by pioneering Seventh-day Adventists who believed in whole-person health healing the body, mind and spirit AdventHealth has grown into one of the largest nonprofit hospitals in the country, caring for more than two million patient visits per year in metro Orlando alone. AdventHealth operates more than 50 hospitals and hundreds of care centers in nearly a dozen states, making it one of the largest faith-based health-care systems in the United States.

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AdventHealth's Central Florida Division encompasses 20 hospitals in the seven counties in and surrounding metro Orlando: Orange, Seminole, Osceola, Polk, Lake, Volusia and Flagler. The Central Florida Division's care network also includes more than 30 Centra Care urgent-care centers; dozens of sports-rehab and imaging centers; and hundreds of physicians, ranging from primary care to a full spectrum of specialties.

AdventHealth Orlando, the division's flagship campus, serves both as a community hospital and as a major tertiary referral hospital for the region, much of the Southeast, the Caribbean and Latin America.

AdventHealth Orlando is a designated statutory teaching hospital and trains physicians from around the world on the newest technology and procedures. The system provides a wide range of health services, including many nationally and internationally recognized programs in cardiology, cancer, women's medicine, neuroscience, diabetes, orthopedics, pediatrics, transplant and advanced surgical programs.

The AdventHealth Research Institute has more than 250 investigators and more than 500 clinical trials in progress. AdventHealth Orlando is also home to the Translational Research Institute for Metabolism & Diabetes and the Nicholson Center for Surgical Advancement.

Contact: Allison MooreT: 1-855-HELPCMT (435-7268)E: allison@hnf-cure.org

(PRNewsfoto/Hereditary Neuropathy Foundation)

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SOURCE Hereditary Neuropathy Foundation

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The Hereditary Neuropathy Foundation's Movement is Medicine Program Expands to Florida and Continues to Shed Light on the Impact Exercise Has on...

Neuroscience Antibodies & Assays Market 2020 Analysis by Overview, Growth, Top Companies, Trends, Demand and Forecast to 2026 – Packaging News 24

Verified Market Research adds new research report on market size for Neuroscience Antibodies & Assays and regional forecasts for 2020-2026. The report provides an in-depth analysis of the Neuroscience Antibodies & Assays market, taking into account market dynamics, segmentation, geographic expansion, the competitive landscape, and various other key issues. The market analysts who prepared the report have thoroughly examined the Neuroscience Antibodies & Assays market and provided reliable and accurate data. They understand the needs of the industry and customers, so they can easily focus on the issues that end users have been looking for. The research report provides an analysis of an assessment of existing and upcoming trends in which players can invest. It also includes an assessment of the players financial prospects and the nature of the competition.

Neuroscience Antibodies & Assays Market was valued at USD 2.42 Billion in 2018 and is projected to reach USD 5.14 Billion by 2026, growing at a CAGR of 9.7% from 2019 to 2026.

This report includes the following Companies; We can also add other companies you want:

Neuroscience Antibodies & Assays Market: Competitive Landscape

The competitive landscape is a must for market participants to withstand the competition in the Neuroscience Antibodies & Assays market. This helps market participants to develop effective strategies to optimize their market positions. In addition, the competitive analysis helps them identify potential benefits and obstacles in the Neuroscience Antibodies & Assays market. This allows them to monitor how their competitors are implementing different strategies, including pricing, marketing, and sales.

Neuroscience Antibodies & Assays Market: Drivers and Limitations

The report section explains the various drivers and controls that have shaped the global market. The detailed analysis of many market drivers enables readers to get a clear overview of the market, including the market environment, government policy, product innovation, development and market risks.

The research report also identifies the creative opportunities, challenges, and challenges of the Neuroscience Antibodies & Assays market. The framework of the information will help the reader identify and plan strategies for the potential. Our obstacles, challenges and market challenges also help readers understand how the company can prevent this.

Neuroscience Antibodies & Assays Market: Segment Analysis

The report section contains segmentations such as application, product type and end user. These segments help determine which parts of the market will improve over others. This section analysis provides information on the most important aspects of developing certain categories better than others. It helps readers understand strategies to make solid investments. The market for Neuroscience Antibodies & Assays is segmented according to product type, applications and end users.

Neuroscience Antibodies & Assays Market: Regional Analysis

This section of the report contains detailed information on the market in different regions. Each region offers a different market size because each state has different government policies and other factors. The regions included in the report are North America, Europe, Asia Pacific, the Middle East and Africa. Information about the different regions helps the reader to better understand the global market.

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Table of Content

1 Introduction of Neuroscience Antibodies & Assays Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology of Verified Market Research

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Neuroscience Antibodies & Assays Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Neuroscience Antibodies & Assays Market , By Deployment Model

5.1 Overview

6 Neuroscience Antibodies & Assays Market , By Solution

6.1 Overview

7 Neuroscience Antibodies & Assays Market , By Vertical

7.1 Overview

8 Neuroscience Antibodies & Assays Market , By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Neuroscience Antibodies & Assays Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Verified market research partners with clients to provide insight into strategic and growth analytics; data that help achieve business goals and targets. Our core values include trust, integrity, and authenticity for our clients.

Analysts with high expertise in data gathering and governance utilize industry techniques to collate and examine data at all stages. Our analysts are trained to combine modern data collection techniques, superior research methodology, subject expertise and years of collective experience to produce informative and accurate research reports.

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TAGS: Neuroscience Antibodies & Assays Market Size, Neuroscience Antibodies & Assays Market Growth, Neuroscience Antibodies & Assays Market Forecast, Neuroscience Antibodies & Assays Market Analysis, Neuroscience Antibodies & Assays Market Trends, Neuroscience Antibodies & Assays Market

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Neuroscience Antibodies & Assays Market 2020 Analysis by Overview, Growth, Top Companies, Trends, Demand and Forecast to 2026 - Packaging News 24