Category Archives: Neuroscience

Sing-Alongs, Mask Donations And Food Deliveries: Acts Of Kindness During The Coronavirus Crisis – WBUR

Coronavirus framed in a different light: well talk about acts of kindness popping up in communities around the country.

Jamil Zaki, professor of psychology at Stanford University. Director of the Stanford Social Neuroscience Lab. Author of The War for Kindness: Building Empathy in a Fractured World." (@zakijam)

Andrea Asuaje, co-host, co-producer and reporter for Kind World, a radio series and podcast. (@aasuaje)

Exerpt from The War for Kindness: Building Empathy in a Fractured World" by Jamil Zaki

Excerpted from The War for Kindness: Building Empathy in a Fractured World" by Jamil Zaki 2019 by Crown, an imprint of Penguin Random House. Reprinted with the permission of the publisher, Penguin Random House. All rights reserved.

Exerpt fromJamil Zaki's The War for Kindness: Building Empathy in a Fractured World" --"Thankfully, the Roddenberry hypothesisand the centuries of thought it representsis wrong. Through practice, we can grow our empathy and become kinder as a result.

"This idea might sound surprising, but in fact it is supported by decades of research. Work from many labs, including my own, suggests that empathy is less like a fixed trait and more like a skillsomething we can sharpen over time and adapt to the modern world.

"Consider our diet and exercise habits. Humans evolved in an environment where exercise was constant and sustenance was scarce. In response, we developed a taste for fat, protein, and rest. Now many of us are inundated with fast food and rarely required to exert ourselves. If we allowed our instincts to take over, we could indulge ourselves into an early grave. But many of us dont accept this; we fight to stay healthy, adjusting our diets and going to the gym because we know its the wise thing to do.

"Likewise, even if we have evolved to care only in certain ways, we can transcend those limits. In any given moment, we can turn empathy up or down like the volume knob on a stereo: learning to listen to a difficult colleague, or staying strong for a suffering relative. Over time, we can fine-tune our emotional capacities, building compassion for distant strangers, outsiders, and even other species. We can free our empathy from its evolutionary bonds."

The Washington Post: "Social distancing shouldnt mean losing human connection" "Im writing this from home. If you normally work at an office, I bet youre reading it from home. The coronavirus has shut down businesses, schools, movie theaters and festivals. Stanford, where I teach, has temporarily morphed into an online university.

"World events plant new buzz terms into our public consciousness. This time, its 'social distancing' efforts to keep people healthy by keeping them apart. Social distancing can be many things, including canceling NBA games, screening nursing home visitors and urging people to avoid public places when possible.

"All of these are vital strategies for slowing contagion. They also push against our deep instincts for togetherness, and can worsen our emotional well-being during already trying times."

Stanford News: "Instead of social distancing, practice distant socializing instead, urges Stanford psychologist" "Social distancing voluntarily limiting physical contact with other people has been vital to help slow the spread of the novel coronavirus. But its important that people remain connected otherwise a long-term mental and physical health crisis might follow the viral one, warns Stanford psychologist Jamil Zaki.

"Here, Zaki, an associate professor of psychology in Stanfords School of Humanities and Sciences and director of the Stanford Social Neuroscience Laboratory, discusses strategies to stay connected, starting with the reframing of 'social distancing' to 'physical distancing' to highlight how people can remain together even while being apart.

"Zakis research examines how empathy works and how people can learn to empathize more effectively. He recently authored The War for Kindness: Building Empathy in a Fractured World."

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Sing-Alongs, Mask Donations And Food Deliveries: Acts Of Kindness During The Coronavirus Crisis - WBUR

Can You Really Have Sex in the Coronavirus Era? – The National Interest

Lately, the one topic the entire world is concerned about is the novel coronavirus.

In line with that, as asex positiveneuroscience sexresearcher, I am writing this article with a couple of goals: to inform readers how sex relates to the current pandemic, and to prevent the spread of myths and misinformation in an agitated social environment.

Given the common modes of transmission of respiratory viruses, engaging in certain types of sexual activities may risk spreading the virus. However, expecting people to abstain from sex during times of isolation is unrealistic.

In the current situation, since sex is not a priority as a topic of discussion, misinformation can be easily fostered. People could unwillingly exacerbate the spread of the virus if they do not take the necessary precautions.

So, after washing our hands with soap and water for at least 20 seconds, lets get down to business!

Sex and COVID-19

Can the coronavirus be transmitted sexually? The answer is simple: we do not know. At the moment, there is no reliable research, official communication or scientific report from trusted authorities.

Sexual transmission is not the same as contracting the virus from your sexual partner. You can easily contract the virus from an infected sexual partner by activities like kissing just not through sexual transmission. That term is defined astransmission through sexual contact and fluids including vaginal, oral and anal sex.

Christian Lindmeier, a spokesperson for WHO the World Health Organization told theNew York Timesthatcoronaviruses are not typically sexually transmitted. According to theU.S. Centers for Disease Control and Prevention, there are seven types of coronaviruses, all of which typically affect the respiratory tract in humans.

Other infectious disease expertssupport these observations. But thecoronavirusmay not be limited to the respiratory tract. There issome evidencethat it has beenfound in the feces of infected patients, although theCDC expects the risk of transmission is low.

The novel coranavirusspreads via dropletsthat are expelled when infected people exhale, cough or sneeze. Others become infected by inhaling these droplets, or touching them on a surface and then touching their face. Thus, chances of getting the virus through sexual activities with an infected person is almost certain.

Since the virus is present in respiratory secretions, it is easy to assume almost any sexual practice would lead to its transmission due to close contact. This is not the time to have that sexy social gathering.

The executive director of the American adult industry workers coalition, Michelle L. LeBlanc,called for a voluntary shutdownof all adult entertainment productions during the pandemic to help prevent the spread of the virus.

Does isolation mean no sex?

Sexual behaviour is a realm where variety is highly valued. Although it is practically impossible to ask people not to have sex, perhaps we could help by suggesting simple and small experimenting?

Since you can be infected with the virus andnot have symptoms, the only reliable way to know if you or your partner are infected is through testing. If you and your partner have no symptoms and have stayed at home, then sex likely poses no risk.

We can contribute to the control of the COVID-19 pandemic by taking a few precautions. We can also learn to thrive differently in times of sexual need. Here are a few general recommendations to keep in mind that can reduce the risk of COVID-19 transmission.

Safer sex

First and foremost, wash your hands thoroughly for at least 20 seconds with soap and warm water before and after you do anything.

Think of it as the new foreplay in the time of isolation!

If you think you need a face mask, most likely you dont. Mask use is recommended by WHO onlyin specific cases. There is evidence that some women in Japan have worn face masks as a way to increase their attractiveness by hiding their faces when not wearing makeup. However, a study of this practice showed that for some, face masksdecrease facial attractiveness.

You can further minimize the risk of contagion by using condoms, dental dams or latex gloves. These may not be your cup of tea, but desperate times calls for fun measures.

Non-conventional intimacy

The acts associated with sexual intimacy can have as many variations and alternatives as the imagination can conceive. Instead of kissing and sexual intercourse, try erotic massage, chat rooms, spooning, mutual masturbation, watching or reading erotica, watching your partner pleasure themselves, etc.

Rimming (mouth to anus) should be out of the picture completely.

Engaging in any form of sexual intercourse involves an unnecessary risk, especially when there is stillno vaccine or medicine available to treat or prevent the disease.

Everybody knows we like what we cannot get. Refraining or abstaining from your favourite activities to minimize risk will only make them sweeter at the end, once the storm has passed.

Communication

It is essential to stay in tune with your partner, especially if you dont feel well or simply do not want to engage in any sexual activity. For the singles out there, just like some businesses are taking a toll due to the curfew, the dating pool may be hurt, too.

It is definitely not the best time to go on a Tinder date or expose yourself to unnecessary risks from new partners. If they really like you, they will wait. If you already have started engaging with people, keeping track of whom you have been with, where and when, is a good idea. There is no evidence that kissing through a mask is a safe practice.

Stay informed

The novel coronavirus is no joke, and it has already taken thousands of lives around the world andseveral livesin Canada. We all can do something to prevent the spread and keep those at risk safe.

Read reliable information. Do not panic. Stay indoors for now. Fear, rumours and misinformation spread quickly. Crucially, we need to trust the recommendations of scientists.

With appropriate efforts from our governments, scientists and our fellow humans, along with the right amount of patience, we will overcome this pandemic and hopefully will be able to go back to our regular lives. Maybe then, we can resume our more so-called dirty practices.

[Our newsletter explains whats going on with the coronavirus pandemic. Subscribe now.]

Gonzalo R. Quintana Zunino, PhD, Behavioural Neuroscience, Concordia University

This article is republished fromThe Conversationunder a Creative Commons license. Read theoriginal article.

Image: Reuters.

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Can You Really Have Sex in the Coronavirus Era? - The National Interest

Immersion Neuroscience Index Reveals the Public Craves Direction From Its Elected Leaders, Not Celebrities, During a Crisis – StreetInsider.com

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Immersion Neuroscience Index Reveals the Public Craves Direction From Its Elected Leaders, Not Celebrities, During a Crisis - StreetInsider.com

MINERVA NEUROSCIENCES TO HOST KEY OPINION LEADER MEETING ON ROLUPERIDONE: A POTENTIALLY NOVEL MECHANISM TO TREAT THE NEGATIVE SYMPTOMS OF…

Call at 8:00 a.m. Eastern Time on Tuesday, March 31, 2020

WALTHAM, Mass., March 24, 2020 (GLOBE NEWSWIRE) -- Minerva Neurosciences, Inc. (NERV), a clinical-stage biopharmaceutical company focused on the development of therapies addressing high unmet medical needs in the treatment of central nervous system (CNS) disorders, today announced that it will host a Key Opinion Leader (KOL) call on roluperidone and the treatment of the negative symptoms of schizophrenia on Tuesday, March 31, 2020.

Dr. Remy Luthringer, Executive Chairman and Chief Executive Officer of Minerva, will join William T. Carpenter, MD, University of Maryland, Ofer Agid, MD, University of Toronto, John Kane, MD, Hofstra University/ Northwell Health System, and Stephen Marder, MD, UCLA, to discuss the treatment of negative symptoms of schizophrenia.

In the second quarter of 2020, Minerva expects to announce top line results from a Phase 3 study with roluperidone in patients diagnosed with schizophrenia with negative symptoms. Roluperidone is the only molecule in advanced clinical development that to date has shown a specific effect on negative symptoms in schizophrenia.

Tuesday, March 31, 8:00 a.m. Eastern Time

Dr. Carpenter is a Professor of the University of Maryland School of Medicine and past Director of the Maryland Psychiatric Research Center. He is Past-President of the American College of Neuropsychopharmacology and chairs the scientific program committee of the Brain and Behavior Research Foundation. He also chaired the DSM-V Psychosis Work Group.

Dr. Agid is Clinician Scientist and Psychiatrist in the Schizophrenia Program and Medical Head, Ambulatory Services and the Lead Psychiatrist, Partial Hospital Program at the Schizophrenia Program, Centre for Addiction and Mental Health and Associate Professor in the Department of Psychiatry at the University of Toronto.

Dr. Kane is Senior Vice President for Behavioral Health Services of the Northwell Health System. He is Chairman of Psychiatry and Professor of Psychiatry and Molecular Medicine at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. He has chaired review and advisory committees at the NIMH and the Food and Drug Administration and has served as President of the Schizophrenia International Research Society and the American Society of Clinical Psychopharmacology.

Dr. Marder is currently the Director of the Veterans Integrated Service Network 22 Mental Illness Research, Education Clinical Center for the Department of Veterans Affairs and the Director of the Section on Psychosis at the UCLA Neuropsychiatric Institute. He is a Professor and the Vice Chair for Education at the Semel Institute for Neuroscience at UCLA.

About Minerva Neurosciences

Minervas proprietary compounds include: roluperidone (MIN-101), in clinical development for schizophrenia; seltorexant (MIN-202 or JNJ-42847922), in clinical development for insomnia and MDD; and MIN-301, in pre-clinical development for Parkinsons disease. Minervas common stock is listed on the NASDAQ Global Market under the symbol NERV. For more information, please visit http://www.minervaneurosciences.com.

Forward-Looking Safe Harbor Statement

This press release contains forward-looking statements which are subject to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts, reflect managements expectations as of the date of this press release, and involve certain risks and uncertainties. Forward-looking statements include statements herein with respect to the timing and scope of future clinical trials and results of clinical trials with roluperidone (MIN-101); the clinical and therapeutic potential of this compound; the timing and outcomes of future interactions with U.S. and foreign regulatory bodies; our ability to successfully develop and commercialize our therapeutic products; the sufficiency of our current cash position to fund our operations; and managements ability to successfully achieve its goals. These forward-looking statements are based on our current expectations and may differ materially from actual results due to a variety of factors including, without limitation, whether roluperidone will advance further in the clinical trials process and whether and when, if at all, it will receive final approval from the U.S. Food and Drug Administration or equivalent foreign regulatory agencies and for which indications; whether any of our therapeutic products will be successfully marketed if approved; whether any of our therapeutic product discovery and development efforts will be successful; managements ability to successfully achieve its goals; our ability to raise additional capital to fund our operations on terms acceptable to us; and general economic conditions. These and other potential risks and uncertainties that could cause actual results to differ from the results predicted are more fully detailed under the caption Risk Factors in our filings with the Securities and Exchange Commission, including our Annual Report on Form 10-K for the year endedDecember 31, 2019, filed with theSecurities and Exchange Commission on March 9, 2020. Copies of reports filed with theSECare posted on our website at http://www.minervaneurosciences.com. The forward-looking statements in this press release are based on information available to us as of the date hereof, and we disclaim any obligation to update any forward-looking statements, except as required by law.

Story continues

Contact:William B. BoniVP, Investor Relations/Corp. CommunicationsMinerva Neurosciences, Inc.(617) 600-7376

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MINERVA NEUROSCIENCES TO HOST KEY OPINION LEADER MEETING ON ROLUPERIDONE: A POTENTIALLY NOVEL MECHANISM TO TREAT THE NEGATIVE SYMPTOMS OF...

US Intraoperative Neuromonitoring Market Analysis 2020-2024, Featuring Cadwell Industries, Medtronic Plc and NuVasive Inc. – ResearchAndMarkets.com -…

The "Intraoperative Neuromonitoring Market in the US 2020-2024" report has been added to ResearchAndMarkets.com's offering.

The intraoperative neuromonitoring market (IONM) in the US is poised to grow by USD 955.33 mn during 2020-2024, progressing at a CAGR of 10% during the forecast period. This report provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors.

The report offers an up-to-date analysis regarding the current US market scenario, latest trends and drivers, and the overall market environment. The market is driven by increasing number of surgeries that require IONM. In addition, rising adoption of remote IONM is anticipated to boost the growth of the intraoperative neuromonitoring market in the US.

Market Segmentation

Type:

Application:

Methodology:

End-user:

Key trends for intraoperative neuromonitoring market growth

This study identifies rising adoption of remote IONM as the prime reason driving growth in the intraoperative neuromonitoring market in the US during the next few years.

Prominent vendors in the US intraoperative neuromonitoring market

A detailed analysis of around 25 vendors operating in the intraoperative neuromonitoring market in us 2020-2024, including some of the vendors such as Accurate Neuromonitoring LLC, Cadwell Industries Inc., Computational Diagnostics Inc., IntraNerve Neuroscience Holdings LC, Medtronic Plc, Natus Medical Inc., NeuroMonitoring Technologies Inc., Nihon Kohden Corp., NuVasive Inc. and SpecialtyCare Inc. .

Key Topics Covered:

1 Executive Summary

2 Market Landscape

2.1 Market Ecosystem

2.2 Market Characteristics

2.3 Value Chain Analysis

3 Market Sizing

3.1 Market Definition

3.2 Market Segmentation Analysis

3.3 Market Size 2019

3.4 Market Outlook: Forecast 2019-2024

4 Five Forces Analysis

5 Market Segmentation

6 Customer Landscape

7 Geographic Landscape

7.1 Geographic Segmentation

7.2 Geographic Comparison

7.3 Europe - Market Size and Forecast 2019-2024

7.4 North America - Market Size and Forecast 2019-2024

7.5 APAC - Market Size and Forecast 2019-2024

7.6 South America - Market Size and Forecast 2019-2024

7.7 MEA - Market Size and Forecast 2019-2024

7.8 Key Leading Countries

7.9 Market Opportunity

8 Drivers, Challenges and Trends

8.1 Market Drivers

8.2 Market Challenges

8.3 Market Trends

9 Vendor landscape

9.1 Overview

9.2 Landscape Disruption

10 Vendor Analysis

10.1 Vendors Covered

10.2 Market Positioning of Vendors

11 Appendix

11.1 Scope of the report

11.2 Currency conversion rates for US$

11.3 Research methodology

11.4 Information sources

11.5 List of abbreviations

11.6 List of Exhibits

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/xsf05j

About ResearchAndMarkets.com

ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200324005412/en/

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ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900

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Yale Offers A Free Online Course In Happiness – wmmr.com

With everyone quarantined due to the COVID-19 virus, a free online Happiness class could not come at a better time than right now.

According toCNN, Yale Universitys mega-popular happiness course is available for free online through Coursera.

Course creator Laurie Santos, a Yale psychology professor, told CNN, Were in a particularly challenging time not just for this health crisis, this physical health crisis, but also a potential mental health crisis as well.

She explained, Our minds lie to us all the time. We miswant things. We think we need to change our life circumstances to become happier. What plays a much bigger role are our simple practices, simple acts like making a social connection, or taking time for gratitude, or taking time to be in the present moment. Many people mistakenly believe happiness is just around the corner if we land a better job, find a more attractive mate, or buy a bigger house. But the neuroscience literature doesnt back that up.

Santos added, Happiness and contentedness stem from repeatedly doing simple tasks, rather than herculean ones. I take the science of happiness as giving us a lot of good news.

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Yale Offers A Free Online Course In Happiness - wmmr.com

Yale’s massively popular ‘happiness’ course is available free online – WXII The Triad

Above video: Here are unique ways to maintain social distancing during COVID-19 outbreakAs people are spending more time at home and working to stay sane during the coronavirus pandemic, they might be able to find solace in Yale University's mega-popular "happiness" course, which is available for free online through Coursera."We're in a particularly challenging time, not just for this health crisis, this physical health crisis, but also a potential mental health crisis, as well," course creator Laurie Santos, a Yale psychology professor, told CNN's Christiane Amanpour this week.The course went online for free about two years ago under the name "The Science of Well Being," according to the Yale Daily News. Anyone can audit the course for free, and $49 lets you complete assignments, submit them for a grade and earn a certificate of completion.Although in-person social connections matter, Santos says the good news from science is that much of happiness stems from cultivating healthy practices and routines.And the dramatic reorientation of your life might actually give you an opportunity in the coming weeks to rethink your daily rituals and therefore rewire your brain toward a happier life.The course was a campus phenomenonSantos hatched the idea for the course because she's the head of Yale's Silliman College and lives with students "in the trenches." (Think of it like Professor Minerva McGonagall heading Gryffindor House in the Harry Potter universe).Eating daily with students, she said she was "shocked at the kind of mental health issues" she was seeing, and noted that it's "a national trend that's getting worse."So she created a course called "Psychology and the Good Life," which starts by offering students insights from psychology and neuroscience about what drives happiness. In its second half, the course challenges students in behavior change exercises to help rewire the brain.Almost 1,200 students enrolled in the class, or about one in four students on campus, and it became the most popular class in Yale's more than 300-year history.Happiness comes from the simple things"Our minds lie to us all the time. We mis-want things. We think we need to change our life circumstances to become happier," Santos says.On the other hand, she finds that "what plays a much bigger role are our simple practices, simple acts like making a social connection, or taking time for gratitude, or taking time to be in the present moment."Many people mistakenly believe happiness is just around the corner if we land a better job, find a more attractive partner or buy a bigger house. But the neuroscience literature doesn't back that up, she says.Happiness and contentedness stem from repeatedly doing simple tasks, rather than herculean ones. "I take the science of happiness as giving us a lot of good news," Santos said.You can audit the course for freeCatie Henderson, a 29-year-old living in Atlanta, Georgia, took the course online last year. She told CNN she had studied philosophy in college and as she has been progressing in her career, she's been looking for more ways to continue her "learning and development."She was attracted to the happiness course and took the plunge after seeing "raving reviews from other students."Her main takeaway was in deconstructing misconceptions many have around happiness, such as mistakenly seeking fulfillment through accomplishments."Getting your dream job or dream spouse won't create happiness. You have to build habits," Henderson said. "And connecting with others is important, but getting right with yourself is equally important."She said she was in fact a little happier after taking the course, but more importantly had generally come to feel more "enlightened and like happiness was in our control."As the world feels like it's spinning out of control, learning what we can control could be vital to finding the silver lining during the age of coronavirus.

Above video: Here are unique ways to maintain social distancing during COVID-19 outbreak

As people are spending more time at home and working to stay sane during the coronavirus pandemic, they might be able to find solace in Yale University's mega-popular "happiness" course, which is available for free online through Coursera.

"We're in a particularly challenging time, not just for this health crisis, this physical health crisis, but also a potential mental health crisis, as well," course creator Laurie Santos, a Yale psychology professor, told CNN's Christiane Amanpour this week.

The course went online for free about two years ago under the name "The Science of Well Being," according to the Yale Daily News. Anyone can audit the course for free, and $49 lets you complete assignments, submit them for a grade and earn a certificate of completion.

Although in-person social connections matter, Santos says the good news from science is that much of happiness stems from cultivating healthy practices and routines.

And the dramatic reorientation of your life might actually give you an opportunity in the coming weeks to rethink your daily rituals and therefore rewire your brain toward a happier life.

Santos hatched the idea for the course because she's the head of Yale's Silliman College and lives with students "in the trenches." (Think of it like Professor Minerva McGonagall heading Gryffindor House in the Harry Potter universe).

Eating daily with students, she said she was "shocked at the kind of mental health issues" she was seeing, and noted that it's "a national trend that's getting worse."

So she created a course called "Psychology and the Good Life," which starts by offering students insights from psychology and neuroscience about what drives happiness. In its second half, the course challenges students in behavior change exercises to help rewire the brain.

Almost 1,200 students enrolled in the class, or about one in four students on campus, and it became the most popular class in Yale's more than 300-year history.

"Our minds lie to us all the time. We mis-want things. We think we need to change our life circumstances to become happier," Santos says.

On the other hand, she finds that "what plays a much bigger role are our simple practices, simple acts like making a social connection, or taking time for gratitude, or taking time to be in the present moment."

Many people mistakenly believe happiness is just around the corner if we land a better job, find a more attractive partner or buy a bigger house. But the neuroscience literature doesn't back that up, she says.

Happiness and contentedness stem from repeatedly doing simple tasks, rather than herculean ones. "I take the science of happiness as giving us a lot of good news," Santos said.

Catie Henderson, a 29-year-old living in Atlanta, Georgia, took the course online last year. She told CNN she had studied philosophy in college and as she has been progressing in her career, she's been looking for more ways to continue her "learning and development."

She was attracted to the happiness course and took the plunge after seeing "raving reviews from other students."

Her main takeaway was in deconstructing misconceptions many have around happiness, such as mistakenly seeking fulfillment through accomplishments.

"Getting your dream job or dream spouse won't create happiness. You have to build habits," Henderson said. "And connecting with others is important, but getting right with yourself is equally important."

She said she was in fact a little happier after taking the course, but more importantly had generally come to feel more "enlightened and like happiness was in our control."

As the world feels like it's spinning out of control, learning what we can control could be vital to finding the silver lining during the age of coronavirus.

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Yale's massively popular 'happiness' course is available free online - WXII The Triad

From 15 years of heroin addiction to becoming a neuroscience lecturer – The Irish Times

Every morning psychology lecturer and author Brian Pennie wakes up very early and does five things: meditation, affirmation, visualisation, inner child work and gratitude. It makes up an acronym mavig and he swears by it. He does these things every morning, he says, whether itsWorld War III orthe coronavirus.

Seven years ago, when he was in the throes of a serious heroin addiction, Pennies mornings looked quite different. He would awake to an overly loud alarm playing In the Morning by Razorlight, after which a couple of benzos and some gear would get him out of bed. I had no emotional world. I had no spiritual world. That was all gone . . . My brother, who I lived with, says he still gets shivers when he hears that song.

Pennies memoir, Bonus Time, tells the story of his journey through a 15-year heroin addiction on to a post-recovery career as a speaker, neuroscience lecturer and PhD student.

All addiction, Pennie says, has its roots in trauma. His own trauma, he now believes, stems from an operation he had as a baby. In those days, operations on infants were misguidedly carried out without anaesthetic and, with what he knows now about psychology, Pennie reckons this might explain the feelings of unease and anxiety he carried with him through his childhood and into adulthood.

I still have weird feelings around bodily sensations, he says. Thats my Everest. If you said to me, Ill give you a million euros, Brian, if you can feel your pulse for a minute, Id probably do it for a million quid but I stillhave negative associations around my heartbeat and my pulse. He rubs his side. Im rubbing my scar as I talk about it . . . I imagine for the first year of my life I had horrible bodily sensations; I imagine that as a baby I could feel my heartbeat, I could feel the pulse and I associated that with pain.

Throughout his childhood he was restless and agitated. I had sirens in my head, he says. I was just such a worrier. I worried about my parents dying. I had huge fear of death and a huge fear of losing people close to me.

Drugs offered him relief from this. His first drug, he says, was a cigarette. He remembers it very clearly. All my friends were smoking and I remember thinking they were idiots . . . but something just shifted one day and one of my mates said, I love the head buzz you get off that and that piqued my interest. And within weeks I was smoking hash.

Pennie grew up in working-class Ladyswell in Blanchardstown, but went to a posher school than many of his friends, St Declans in Cabra. He never felt he fitted in there, he says, and in an attempt to do so he styled himself as a drug dealer. They called me Penpusher. I was such a mediocre drug dealer. I wasnt hard enough to be a drug dealer in [Ladyswell], but I was hard enough for St Declans. He laughs. Which is pathetic and I see that now.

He wanted to be cool. He and his best friends were obsessed with the music and poetry of Jim Morrison. Jim was into a drug called Peyote so we thought we have to do as much acid as we can to be like Jim Morrison and expand our minds.

Did it expand their minds? He laughs. I was completely deluding myself. I just liked the idea of expanding my mind . . . We were into Kurt Cobain as well . . . We wanted to join the 27 Club [musicians who died at the young age of 27], me and my friend Barry. Wed actually say that to each other . . . Were going to burn out, not fade out. Losers fade out. It was just a rationalisation to do more drugs.

When he was 16, Pennie tried methadone. He didnt even know that it was a heroin substitute, he says, though after I wrote the book the friend that I did it with said, You f***ing did know, you mad thing. Memories are crazy.

When he was 17, he did heroin. It was amazing, he says. Even talking about it now I feel a sense of calm. I got a lovely stillness in me . . . It was amazingly powerful and beautiful. I revered it like a god from the heavens.

Since getting clean, he says, he has discovered he can conjure up a purer less artificial version of that still and timeless feeling he got from heroin from meditation. At the time, however, he and his friend Barry (not his real name) fell into serious addictions. Barry, he tells me, is still in addiction and is homeless.

Pennie never saw himself as a real addict. He managed to keep a job in the graphics department of a printing company, and to keep a veneer of a functionality for 15 years while maintaining a serious addiction and a second job as a not particularly competent drug dealer. I wasnt as unusual as I thought I was. People stereotype the addict as someone on the dole, but a lot of people turn up [at methadone clinics] in vans and have jobs.

The fact Pennie managed to keep his job for so long feels miraculous given the reality of his addiction. He was liked by his colleagues and good at his job when he did it, he says, and he thinks some of them mistook his issues for a more socially acceptable addiction to alcohol. But his problems were increasingly obvious.

He describes his typical workday: I would wake up in the morning and there was always stress from the night before. I owed out money. I didnt get paid. I didnt have enough drugs for the day. I would always have a little bit of something to keep me out of the sickness, so I wouldnt be overly anxious at work. Id be frantically making phone calls during the day, and I would probably make up some story to say I had to go to thecredit union or something . . . I had a lot of bulls**t happening to give me excuses to get out of place and go and score some gear. Id come back and smoke it in the industrial estate, come back into the job. Id be looking a lot better now, because I wasnt struggling with anxiety anymore, but I would look stoned. I would probably goof off, on the chair.

He regularly fell asleep at work. After work Id go and try to collect some money, pay the dealers. In the earlier stages, it would have been just about getting more heroin, more benzos just to get nicely stoned. But in the latter years, no matter how many drugs I did, it just brought me to baseline or below baseline.

When the heroin stopped giving him a high, he formulated a plan to move to Afghanistan where he thought it would be stronger. Seriously. I was looking up flights and all, he says. From a neuroscience perspective my body was just in a state of agitation, my nerve endings were always agitated. I just wanted to ease the agitation that was in my body but the more drugs I did, the more agitated I became. I was like a snake trying to eat its own tail.

When his mother discovered piles of old methadone bottles under his bed, he managed to convince everyone he was nearly recovered from addiction rather than supplementing a long-standing methadone prescription with heroin and tablets. He likens himself to a chameleon, changing to fit whatever world he was in. At one point he might play golf with colleagues. At another he might watch a man who had just extracted heroin from his rectum, hand it to him with his faeces-covered hands. I thought, this is not who I am. I dont belong here. Hes a dirt ball, Im not a dirt ball.

It was only when he was finally suspended from work that he sought help. He was told by his doctor that he needed to wean himself off benzodiazepine before hed be allowed into a heroin detox centre and, against all advice, he decided to stop taking the tablets overnight. This is not recommended by the experts for good reason.

After a trip to AA with his sister I fell asleep on her shoulder, smelling of vodka he returned to his flat where, a few nights later, he had a withdrawal related seizure. He bit his tongue down the middle and ended up in hospital. That was the moment when the world completely changed. I was never really going to get clean until I had a seizure . . . My self identity was, I cant cope with anxiety, I need to take heroin. The seizure cracked that shell, and it just opened the door to look at the world in another way. It just broke me mentally, emotionally and physically. It was like I was dead inside afterwards. There was nothing inside of me.

He didnt even have the strength to score drugs at that point, which meant that several weeks later, the benzodiazepine was out of his system and he was in a detox centre coming off heroin and methadone. While there he began reading about mindfulness and psychology and eastern philosophy. He kept a diary, and wrote several overly earnest letters to his family. I genuinely believe the most clarity I ever had in my life was when I was in detox, he says.

This was difficult for some members of his long-suffering family to take. The addict mind kicked in and I thought I was a sage, he says. I told my sister, I have a secret. Ill tell you about when I get out, not realising that I had put them through torture for years. A few weeks after they thought I was dead Im sending them letters [saying things like], eat strawberries and really feel the strawberry.

Nonetheless, he embraced learning and never let go of it. From a neuroscience perspective, if we have that dopamine hit drug, drug, drug, drug, drug and you get clean and dont hook that little dopamine hit on to something else, you are going to feel crap. And what do you do when you feel like crap? You use drugs. I think what saved me was I hooked my dopamine receptors on to a new drug and that drug was learning. I think its really important to try to find what is the positive new drug for someone, and over time help them find balance. Ive never found balance. Im still obsessed about learning. Thats okay. We call it drive. We dont call it addiction anymore.

Since then, Pennie has completed a degree in psychology in NUI Maynooth, is studying for a fully-funded PhD at the institute of neuroscience in TCD, and slowly building a reputation as a speaker and a lecturer. Hes interested in the space where eastern philosophies of mind intersect with western psychology, and over the course of our chat, he quotes thinkers like Anthony de Mello, Eckhart Tolle and Viktor Frankl.

Things havent always gone smoothly, he says, but he insists that hes the happiest person I know. He is very close with his family. He has come up with 200 tools for life, at first to help himself, but which he now imparts to clients in one-on-one sessions and to rooms full of people as a speaker. He lectures in the neuroscience of mindfulness at UCD and the neuroscience of addiction in TCD. In his spare time, he has been interviewing business leaders and public figures about their own strategies for life, and is hoping to turn his findings into another book.

He talks about the importance of affirming your own values (his include boldness, connection, open mindedness), and visualising the things you want to achieve. When he got a box of his books from the publisher, he tells me he was so excited he hurt his hand opening the box. Ive been as honest as I could. My main mantra in life is, be true to your wonderfully weird self. I just let the truth out.

Continued here:
From 15 years of heroin addiction to becoming a neuroscience lecturer - The Irish Times

A New Drug May Be Able to Ease the Side Effects of Medication Against Severe Depression – Technology Networks

About one in five Danes are affected by depression at some point in their lives. The severe depressions may be treated with the so-called tricyclic antidepressants, an antidepressant drug that is more effective than the drugs used for mild and moderate depressions.

But unfortunately, the tricyclic antidepressants also have a downside: significantly more and more serious side effects. So serious that many people stop taking the drug and thus receive no treatment for their depression.

Now, researchers from the Faculty of Health and Medical Sciences at the University of Copenhagen, in collaboration with Lundbeck A/S and the National Institutes of Health in Baltimore, have discovered a substance that may solve that problem.

We have discovered a substance, Lu AF60097, that works in a different way from the ones presently in use. If the new substance works, it may help the existing drugs get rid of the serious side effects, says Professor at the Department of Neuroscience at the Faculty of Health and Medical Sciences, Claus Juul Lland.

Therapeutic effect without side effects

Serotonin is a so-called neurotransmitter, a chemical substance found in the brain. In a person with severe depression, the level of serotonin is very low. Antidepressant drugs make adjustments to get a higher level of active serotonin.

The antidepressants we use today work by going in and binding to the same site as serotonin on the serotonin transporter (SERT). The antidepressants block the return transport of serotonin and thereby also the removal of the active serotonin. But such blockage requires a relatively large dose of the antidepressant substance. And with the tricyclic antidepressants, that causes some serious side effects, says Claus Juul Lland.

The side effects can be anything from life-threatening heart problems to severely dry mouth, visual disorders, development of mania, weight problems and digestive challenges.

The substance discovered by the researchers binds to another site on SERT: the allosteric site. When a substance binds to the allosteric site rather than the same site as serotonin, it is possible to regulate the function of the serotonin transporter instead of completely blocking it.

In this case, we have shown that when we bind this substance to the allosteric site while giving the tricyclic antidepressant, we can amplify the binding of the antidepressant substance. Therefore, we can use a much smaller concentration of the antidepressant substance. It might cause fewer side effects, but have the same therapeutic effect, says Claus Juul Lland.

From concept to drug

The researchers have, over a long period of time and in several rounds, screened a number of substances from Lundbecks drug library to find a substance that had a sufficiently strong link to the allosteric site to make it possible to study the pharmacological effect. With Lu AF60097, they finally succeeded.

But there is still a long way to go before the substance can be used as an actual drug. The researchers have shown that a substance that binds to the allosteric site can have this pronounced, pharmacological effect in cells and in rats. From here, it is up to the pharmaceutical companies to develop substances that may have the same effect in humans.

We have taken the first step. But perhaps also the biggest. We have shown that the concept works. If it also works in practice, hopefully in the future it can be used to treat people with severe depression.The study The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter has been published in Nature Communications.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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A New Drug May Be Able to Ease the Side Effects of Medication Against Severe Depression - Technology Networks

Neuroscience Antibodies & Assays Market Trends, Strong Application Scope, Key Players, Growth Overview and Forecast by 2027 – Jewish Life News

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Neuroscience Antibodies & Assays Market Trends, Strong Application Scope, Key Players, Growth Overview and Forecast by 2027 - Jewish Life News