Category Archives: Neuroscience

Special Issue: The Year in Cognitive Neuroscience (vol 1464) – The New York Academy of Sciences

REVIEWS

The present and future use of functional nearinfrared spectroscopy (fNIRS) for cognitive neuroscience

Paola Pinti, Ilias Tachtsidis, Antonia Hamilton, Joy Hirsch, Clarisse Aichelburg, Sam Gilbert, Paul W. Burgess

Models, movements, and minds: bridging the gap between decision making and action

Nathan J. Wispinski, Jason P. Gallivan, Craig S. Chapman

Recent evidence that attention is necessary, but not sufficient, for conscious perception

Sean Noah, George R. Mangun

Between persistently active and activitysilent frameworks: novel vistas on the cellular basis of working memory

Jan Kamiski, Ueli Rutishauser

Challenging the neurobiological link between number sense and symbolic numerical abilities

Eric D. Wilkey, Daniel Ansari

Musical anhedonia and rewards of music listening: current advances and a proposed model

Amy M. Belfi, Psyche Loui

The intersection between the oculomotor and hippocampal memory systems: empirical developments and clinical implications

Jennifer D. Ryan, Kelly Shen, ZhongXu Liu

Allocentric representations for target memory and reaching in human cortex

Ying Chen, J. Douglas Crawford

Ovarian hormones: a long overlooked but critical contributor to cognitive brain structures and function

Adriene M. Beltz, Jason S. Moser

The importance of diversity in cognitive neuroscience

Vonetta M. Dotson, Audrey Duarte

A new look at the cognitive neuroscience of video game play

Gillian Dale, Augustin Joessel, Daphne Bavelier, C. Shawn Green

Inhibition in selective attention

Dirk van Moorselaar, Heleen A. Slagter

Beyond the feedforward sweep: feedback computations in the visual cortex

Gabriel Kreiman, Thomas Serre

Evaluating the neurophysiological evidence for predictive processing as a model of perception

Kevin S. Walsh, David P. McGovern, Andy Clark, Redmond G. O'Connell

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Special Issue: The Year in Cognitive Neuroscience (vol 1464) - The New York Academy of Sciences

Tracking the Spread of Tau Through the Brain – Technology Networks

In the fight against neurodegenerative diseases such as frontotemporal dementia, Alzheimer's and Chronic Traumatic Encephalopathy, the tau protein is a major culprit. Found abundantly in our brain cells, tau is normally a team player it maintains structure and stability within neurons, and it helps with transport of nutrients from one part of the cell to another.All that changes when tau misfolds. It becomes sticky and insoluble, aggregating and forming neurofibrillary tangles within neurons, disrupting their function and ultimately killing them. Worse, it probably can take relatively few misfolded tau proteins from one cell to turn its neighbors into malfunctioning, dying brain cells.

"This abnormal form of tau starts to spread from cell to cell," said UC Santa Barbara neuroscientist Kenneth S. Kosik. "It's reminiscent of a serious problem that's known in biology, called prion diseases, such as mad cow disease."

Importantly, unlike true prion diseases, which are spread by contact with infected tissue or bodily fluid, prion-like diseases such as frontotemporal dementia and other tauopathies aren't contagious they can't be spread from person to person or by coming into contact with infected tissue. However, the replication is eerily familiar: A misfolded tau protein gets out of a cell and gets taken up by a normal neighboring cell. It then acts as a template in that cell, Kosik explained, which subsequently produces misfolded tau. Over and over again, the cells produce and secrete the toxic knockoff version of tau until whole regions of the brain are affected, which over time will rob a person of their cognitive and physical functions.

What if the spread could be contained? If caught early enough, controlling the proliferation of pathological tau could keep the neurodegenerative disease from progressing, and give the patient a shot at a normal life. But in order to do that, scientists first have to understand how the protein gets around.

Kosik and his team have uncovered one such mechanism by which tau travels from neuron to neuron. Not only does it shed light on the extensively studied but rather poorly understood tau propagation in neurodegenerative disease, it hints at a way to control the spread of pathological tau.

"The discovery of a mechanism by which tau transits from cell to cell provides a clue that will open up a deep structural approach to the design molecules that can prevent tau spread," said Kosik, who is the Harriman Professor of Neuroscience Research in UC Santa Barbara's Department of Molecular, Cellular, and Developmental Biology.

The major player in this mechanism of uptake and spread, it turns out, is the low-density lipoprotein called LRP1 (low density lipoprotein receptor-related protein 1). It's located on the brain cell membrane and is involved is several biological processes, among them helping the neuron take in cholesterol, which is used as part of cellular structure.

LRP1, the researchers discovered, takes up tau in neighboring cells after it escapes from a cell into the extracellular space. One of several low density lipoprotein receptors, LRP1 was singled out by process of elimination: By systematically inhibiting the expression of each of the members of this family via CRISPRi technology, and exposing them to tau, the researchers determined that genetic silencing of LRP1 effectively inhibited tau uptake.

"This protein is an interesting one in its own right because it's a little bit like an extracellular trash can," Kosik said. "It doesn't just pick up tau; if there's other rubbish out there, it also picks it up."

But what about tau is LRP1 recognizing? Digging deeper, the scientists found that a stretch of the amino acid lysine on the tau protein acts as kind of the secret handshake that opens the doors to the neuron.

"So these are all clues," Kosik said.Stopping the Spread"Since our cellular work showed that tau can interact with the cell-surface receptor LRP1 and that this causes tau's endocytosis, our hypothesis was that if we reduce LRP1 expression in the mice we should reduce the ability for neighboring neurons to take up tau," explained the study's lead author, postdoctoral researcher Jennifer Rauch.

To back their in-vitro studies, the researchers injected tau into mice, some of which had their LRP1 genes downregulated by a LRP1 suppressor RNA. The tau proteins were bound by a small string of amino acids to a green fluorescent protein to help the scientists observe tau after it was injected.

"As soon as this construct is in a cell, the amino acid connector gets cut, and the fluorescent protein and tau separate from each other," Kosik explained. What they found was that in the animals with normal LRP1, the tau had a tendency to spread; in the LRP1-suppressed mice, the protein stayed put, greatly reducing the likelihood that it would be taken up and replicated by other, normal neurons. "This is the first time we've seen the complete obliteration of tau spread," he said.

"When we reduce LRP1 expression, we see reduced tau spread in the animals," said Rauch, who has previously worked on the role of heparan sulphate proteoglycans on tau uptake. She pointed out a recent study that included Kosik and graduate student Juliana Acost-Uribe that described a patient with a severe genetic form of early-onset Alzheimers's but was spared getting the disease due to a second mutation that appeared to prevent tau spread. The team is keen to learn how this patient's second mutation might prevent tau spread possibly by interacting with LRP1.

"Next," Rauch said, "we are focusing on trying to decipher the interface of the tau-LRP1 interaction and understand if this could be a drug-able target."ReferenceRauch et al. (2020) LRP1 is a master regulator of tau uptake and spread. Nature. DOI: https://doi.org/10.1038/s41586-020-2156-5

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Tracking the Spread of Tau Through the Brain - Technology Networks

Neuroscience Market Detailed Analysis of Current Industry Figures With Forecasts Growth by 2026| GE Healthcare, Siemens Healthineers, Noldus…

Complete study of the global Neuroscience market is carried out by the analysts in this report, taking into consideration key factors like drivers, challenges, recent trends, opportunities, advancements, and competitive landscape. This report offers a clear understanding of the present as well as future scenario of the global Neuroscience industry. Research techniques like PESTLE and Porters Five Forces analysis have been deployed by the researchers. They have also provided accurate data on Neuroscience production, capacity, price, cost, margin, and revenue to help the players gain a clear understanding into the overall existing and future market situation.

Key companies operating in the global Neuroscience market include _ GE Healthcare, Siemens Healthineers, Noldus Information Technology, Mightex Bioscience, Thomas RECORDING GmbH, Blackrock Microsystems, Tucker-Davis Technologies, Plexon, Phoenix Technology Group, NeuroNexus, Alpha Omega Neuroscience Breakdown Data by Type

Get PDF Sample Copy of the Report to understand the structure of the complete report: (Including Full TOC, List of Tables & Figures, Chart) :

https://www.qyresearch.com/sample-form/form/1437954/global-neuroscience-market

Segmental Analysis

The report has classified the global Neuroscience industry into segments including product type and application. Every segment is evaluated based on growth rate and share. Besides, the analysts have studied the potential regions that may prove rewarding for the Neuroscience manufcaturers in the coming years. The regional analysis includes reliable predictions on value and volume, thereby helping market players to gain deep insights into the overall Neuroscience industry.

Global Neuroscience Market Segment By Type:

, Whole Brain Imaging, Neuro-Microscopy, Electrophysiology Technologies, Neuro-Cellular Manipulation, Stereotaxic Surgeries, Animal Behavior, Other, Whole Brain Imaging, Neuro-Microscopy, and Electrophysiology Technologies are the top three types of neuroscience, with a combined market share of 62% Neuroscience Breakdown Data by Application,

Global Neuroscience Market Segment By Application:

Hospitals, Diagnostic Laboratories, Research Institutes, Other, Neuroscience is applied mostly in the hospital with a market share of 47%. It is followed by Research Institutes and Diagnostic Laboratories

Competitive Landscape

It is important for every market participant to be familiar with the competitive scenario in the global Neuroscience industry. In order to fulfil the requirements, the industry analysts have evaluated the strategic activities of the competitors to help the key players strengthen their foothold in the market and increase their competitiveness.

Key companies operating in the global Neuroscience market include _ GE Healthcare, Siemens Healthineers, Noldus Information Technology, Mightex Bioscience, Thomas RECORDING GmbH, Blackrock Microsystems, Tucker-Davis Technologies, Plexon, Phoenix Technology Group, NeuroNexus, Alpha Omega Neuroscience Breakdown Data by Type

Key questions answered in the report:

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TOC

Table of Contents 1 Report Overview1.1 Study Scope1.2 Key Market Segments1.3 Players Covered: Ranking by Neuroscience Revenue1.4 Market Analysis by Type1.4.1 Global Neuroscience Market Size Growth Rate by Type: 2020 VS 20261.4.2 Whole Brain Imaging1.4.3 Neuro-Microscopy1.4.4 Electrophysiology Technologies1.4.5 Neuro-Cellular Manipulation1.4.6 Stereotaxic Surgeries1.4.7 Animal Behavior1.4.8 Other1.5 Market by Application1.5.1 Global Neuroscience Market Share by Application: 2020 VS 20261.5.2 Hospitals1.5.3 Diagnostic Laboratories1.5.4 Research Institutes1.5.5 Other 1.6 Study Objectives 1.7 Years Considered 2 Global Growth Trends by Regions2.1 Neuroscience Market Perspective (2015-2026)2.2 Neuroscience Growth Trends by Regions2.2.1 Neuroscience Market Size by Regions: 2015 VS 2020 VS 20262.2.2 Neuroscience Historic Market Share by Regions (2015-2020)2.2.3 Neuroscience Forecasted Market Size by Regions (2021-2026) 2.3 Industry Trends and Growth Strategy 2.3.1 Market Top Trends 2.3.2 Market Drivers2.3.3 Market Challenges2.3.4 Porters Five Forces Analysis2.3.5 Neuroscience Market Growth Strategy2.3.6 Primary Interviews with Key Neuroscience Players (Opinion Leaders) 3 Competition Landscape by Key Players3.1 Global Top Neuroscience Players by Market Size3.1.1 Global Top Neuroscience Players by Revenue (2015-2020)3.1.2 Global Neuroscience Revenue Market Share by Players (2015-2020)3.1.3 Global Neuroscience Market Share by Company Type (Tier 1, Tier 2 and Tier 3)3.2 Global Neuroscience Market Concentration Ratio3.2.1 Global Neuroscience Market Concentration Ratio (CR5 and HHI)3.2.2 Global Top 10 and Top 5 Companies by Neuroscience Revenue in 20193.3 Neuroscience Key Players Head office and Area Served3.4 Key Players Neuroscience Product Solution and Service3.5 Date of Enter into Neuroscience Market3.6 Mergers & Acquisitions, Expansion Plans 4 Breakdown Data by Type (2015-2026)4.1 Global Neuroscience Historic Market Size by Type (2015-2020)4.2 Global Neuroscience Forecasted Market Size by Type (2021-2026) 5 Neuroscience Breakdown Data by Application (2015-2026)5.1 Global Neuroscience Market Size by Application (2015-2020)5.2 Global Neuroscience Forecasted Market Size by Application (2021-2026) 6 North America6.1 North America Neuroscience Market Size (2015-2020)6.2 Neuroscience Key Players in North America (2019-2020)6.3 North America Neuroscience Market Size by Type (2015-2020)6.4 North America Neuroscience Market Size by Application (2015-2020) 7 Europe7.1 Europe Neuroscience Market Size (2015-2020)7.2 Neuroscience Key Players in Europe (2019-2020)7.3 Europe Neuroscience Market Size by Type (2015-2020)7.4 Europe Neuroscience Market Size by Application (2015-2020)(2015-2020) (2015-2020) (2015-2020) (2015-2020) 8Key Players Profiles8.1 GE Healthcare8.1.1 GE Healthcare Company Details8.1.2 GE Healthcare Business Overview and Its Total Revenue8.1.3 GE Healthcare Neuroscience Introduction8.1.4 GE Healthcare Revenue in Neuroscience Business (2015-2020))8.1.5 GE Healthcare Recent Development8.2 Siemens Healthineers8.2.1 Siemens Healthineers Company Details8.2.2 Siemens Healthineers Business Overview and Its Total Revenue8.2.3 Siemens Healthineers Neuroscience Introduction8.2.4 Siemens Healthineers Revenue in Neuroscience Business (2015-2020)8.2.5 Siemens Healthineers Recent Development8.3 Noldus Information Technology8.3.1 Noldus Information Technology Company Details8.3.2 Noldus Information Technology Business Overview and Its Total Revenue8.3.3 Noldus Information Technology Neuroscience Introduction8.3.4 Noldus Information Technology Revenue in Neuroscience Business (2015-2020)8.3.5 Noldus Information Technology Recent Development8.4 Mightex Bioscience8.4.1 Mightex Bioscience Company Details8.4.2 Mightex Bioscience Business Overview and Its Total Revenue8.4.3 Mightex Bioscience Neuroscience Introduction8.4.4 Mightex Bioscience Revenue in Neuroscience Business (2015-2020)8.4.5 Mightex Bioscience Recent Development8.5 Thomas RECORDING GmbH8.5.1 Thomas RECORDING GmbH Company Details8.5.2 Thomas RECORDING GmbH Business Overview and Its Total Revenue8.5.3 Thomas RECORDING GmbH Neuroscience Introduction8.5.4 Thomas RECORDING GmbH Revenue in Neuroscience Business (2015-2020)8.5.5 Thomas RECORDING GmbH Recent Development8.6 Blackrock Microsystems8.6.1 Blackrock Microsystems Company Details8.6.2 Blackrock Microsystems Business Overview and Its Total Revenue8.6.3 Blackrock Microsystems Neuroscience Introduction8.6.4 Blackrock Microsystems Revenue in Neuroscience Business (2015-2020)8.6.5 Blackrock Microsystems Recent Development8.7 Tucker-Davis Technologies8.7.1 Tucker-Davis Technologies Company Details8.7.2 Tucker-Davis Technologies Business Overview and Its Total Revenue8.7.3 Tucker-Davis Technologies Neuroscience Introduction8.7.4 Tucker-Davis Technologies Revenue in Neuroscience Business (2015-2020)8.7.5 Tucker-Davis Technologies Recent Development8.8 Plexon8.8.1 Plexon Company Details8.8.2 Plexon Business Overview and Its Total Revenue8.8.3 Plexon Neuroscience Introduction8.8.4 Plexon Revenue in Neuroscience Business (2015-2020)8.8.5 Plexon Recent Development8.9 Phoenix Technology Group8.9.1 Phoenix Technology Group Company Details8.9.2 Phoenix Technology Group Business Overview and Its Total Revenue8.9.3 Phoenix Technology Group Neuroscience Introduction8.9.4 Phoenix Technology Group Revenue in Neuroscience Business (2015-2020)8.9.5 Phoenix Technology Group Recent Development8.10 NeuroNexus8.10.1 NeuroNexus Company Details8.10.2 NeuroNexus Business Overview and Its Total Revenue8.10.3 NeuroNexus Neuroscience Introduction8.10.4 NeuroNexus Revenue in Neuroscience Business (2015-2020)8.10.5 NeuroNexus Recent Development8.11 Alpha Omega10.11.1 Alpha Omega Company Details10.11.2 Alpha Omega Business Overview and Its Total Revenue10.11.3 Alpha Omega Neuroscience Introduction10.11.4 Alpha Omega Revenue in Neuroscience Business (2015-2020)10.11.5 Alpha Omega Recent Development 9Analysts Viewpoints/Conclusions 10Appendix10.1 Research Methodology10.1.1 Methodology/Research Approach10.1.2 Data Source10.2 Disclaimer10.3 Author Details

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Neuroscience Market Detailed Analysis of Current Industry Figures With Forecasts Growth by 2026| GE Healthcare, Siemens Healthineers, Noldus...

Woman With COVID-19 May Have Developed Rare Brain Disease From Coronavirus, Her Detroit Doctors Say – Newsweek

A woman in Detroit is thought to be the first person to have brain damage linked to COVID-19, according to the doctors who treated her. The clinicians stressed it is not clear if the rare condition was caused by the new coronavirus, but said it was important for doctors to be aware of it as a possible complication.

The case of the unidentified 58-year-old COVID-19 patient diagnosed with a rare form of brain damage known as acute necrotizing hemorrhagic encephalopathy was detailed in the journal Radiology. The condition has been linked with other viral infections in the past but not yet COVID-19, the authors said.

Dr. Elissa Fory, a neurologist at Detroit's Henry Ford health system who helped to diagnose the woman, said in a statement the patient had experienced a fever, cough and muscle aches. She was rushed by ambulance to an emergency room on March 19, after becoming confused, lethargic and disoriented.

According to the journal article, the woman tested positive for COVID-19, and negative for the flu. The team were unable to test the woman's cerebrospinal fluid for SARS-CoV-2, the virus that causes COVID-19 (not to be confused with the SARS virus).

MRI scans showed abnormal lesions in parts of the woman's brain associated with consciousness, sensation and memory function, the statement explained. "The 58-year-old female patient is hospitalized in serious condition," the health system said.

The authors of the paper explained acute necrotizing encephalopathy is a "rare complication" of viral infections such as the flu, particularly in children. It has been linked to cytokine storms, where the immune system dangerously overreacts. This can "result in blood-brain-barrier breakdown," they said.

Growing evidence suggests some COVID-19 patients might experience cytokine storms, according to the team.

Fory said: "This is significant for all providers to be aware of and looking out for in patients who present with an altered level of consciousness. We need to be thinking of how we're going to incorporate patients with severe neurological disease into our treatment paradigm.

"This complication is as devastating as severe lung disease."

As indicated in the map by Statista below, COVID-19 has spread to almost every country and territory in the world. According to Johns Hopkins University, almost 1 million cases have been confirmed worldwide, 47,522 people have died, and at least 195,929 have recovered. According to the CDC, common COVID-19 symptoms include a fever, cough, and shortness of breath.

Professor Neil Scolding of the U.K.'s University of Bristol Institute of Clinical Neurosciences, who did not work on the paper, told Newsweek: "This is the first reported case of severe brain inflammation related to COVID-19 and so is highly significant.

"We had suspected this kind of inflammation could occur, since it happensthough rarelywith conventional influenza virus infection, and with other viruses related to COVID-19."

Scolding said the study "serves as a valuable reminder to the medical community to look out for this complication."

Asked who might be most at risk of such a complication, Scolding said: "We don't know who will be most susceptible. With flu, it is children who are more likely to get this complicationbut children seem rather resistant to COVID-19, and the individual in this report is an adult."

Scolding stressed: "We do think it will remain a rather rare complication, and so I do not think people should start routinely looking out for confusion or other brain-related symptoms."

Professor Cris S. Constantinescu, of the Division of Clinical Neuroscience at the U.K.'s University of Nottingham Queen's Medical Centre, told Newsweek that while the case study describes a single report, it adds to the emerging evidence that SARS-cov-2 can affect the nervous system.

As the test to detect the virus in the cerebrospinal fluid could not be performed, "it is unclear whether the encephalitis was the direct effect of viral invasion" he said.

Constantinescu said it is "important" for people to look out for symptoms such as confusion as a potential COVID-19 symptom.

"In particular people with neurological diseases requiring immunosuppressive treatments such as multiple sclerosis or myasthenia gravis should be vigilant as they are at higher risk of infection, and have diminished immune responses to the infection.

"They should not always attribute new neurological symptoms [to] their underlying neurological disease. Also COVID-19 patients and carers should be aware of potential neurological problems," he said.

As the disease spreads, said Constantinescu, "we will become increasingly aware of neurological complications of COVID-19 and of the implications of COVD-19 infections in people with underlying neurological conditions. Even rare complications such as this one have great informative value."

Hygiene advice

Medical advice

Mask and glove usage

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Woman With COVID-19 May Have Developed Rare Brain Disease From Coronavirus, Her Detroit Doctors Say - Newsweek

Deep Bench: Reframing the discussion from mental health to brain health – WSAW

(WZAW) -- Our nation is in the midst of a growing mental illness epidemic with conditions like suicide, depression, bipolar disorders and addictions increasing dramatically.

Standard treatments and success rates have barley changed in the last seven decades and now neuroscience is transforming psychiatry.

"If you get your brain right, the mind will follow."

That's the advice from Dr. Daniel Amen. He's a psychiatrist and best-selling author of the book "The End of Mental Illness". Dr. Amen talked to Holly Chilsen about his book, and how it's aim is the change the conversation about mental health into brain health.

"Nobody really wants to see a psychiatrist. No one wants to be labeled as defective or abnormal, but everyone wants a better brain," he said.

Amen Clinics has the worlds largest database of functional brain scans relating to behavior. Dr. Amen has been working on brain imaging for the past 30 years, conducting about 170,000 scans, and said researchers realized that it's not mental health issues people face, it's "brain health issues that steal your mind."

"This one idea changes everything."

He added that the mind is a result of the physical functioning of your brain.

"So you can go to therapy for a very long time, but it won't help if your brain's not right," he said. "And I'm a fan of therapy if your brain's right."

It comes down to optimizing the physical functioning of your brain. People start seeing their problems as medical and not moral. He said the stigma of the mental illness label, damaging and devastating on its own, can often prevent sufferers from getting the help they need.

"With this message, there's an increase in forgiveness and compassion from families," he said.

He said ways to improve your brain health are to make sure you're sticking to a healthy diet, exercise regularly and take supplements like vitamins. It's also important to think in different ways and practice mindfulness.

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Deep Bench: Reframing the discussion from mental health to brain health - WSAW

The Psychology Behind Events (When They Start Again) – The NonProfit Times

* Editors note: The NPT received the session information from this speaker for this session.

Many nonprofit managers are frustrated by the struggle to create engaging and profitable fundraising events. These managers might try changing venues and revamping themes, but to find event success they should instead be focusing on how they can harness neuroscience and psychology to powerfully connect with guests to create meaningful moments and memorable experiences.

It is imperative to consider psychology and neuroscience during the initial event planning phases. Most fundraisers arent aware that this will have an enormous positive impact on an event guests experience, as well as on the events ultimate profitability, according to A.J. Steinberg, CFRE, principal of Queen Bee Fundraising in Calabasas, Calif. Also, a meaningful experience at a fundraising event starts the process of relationship-building, which opens the door to post-event cultivation in order to turn those guests into donors.

Steinbergs slated session for AFPICON was The Psychology Behind Successful Fundraising Events.Steinberg explained to session attendees that, whether they are aware of it or not, all live events and gatherings play into the basic human need for community and belonging. People crave real connection, especially when it includes experiencing something meaningful with a crowd of like-minded folks, she told The NonProfit Times. Whether packed in a crowd of avid music fans at a live concert or sitting shoulder-to-shoulder singing hymns at a neighborhood church, a live group setting can elevate even mundane experiences into powerful moments.

Nonprofit events have the added opportunity to engage emotional triggers such as the need to feel personally valued and the deep human desire to do good. It is a shame when fundraisers direct the focus of the event to auctions and raffles, said Steinberg. Sure, those are entertaining for guests and can raise some money, but a live events focus should always be on the organizations mission and messaging. People didnt come to your event to buy stuff, they came to be inspired and to fall in love with your organization. People are looking for ways to add meaning in their lives, and it is your job as a nonprofit event producer to give them a reason to partner with your organization to do good in the world.

The choices made when planning nonprofit events heavily impact guests psychological and emotional triggers. Understanding these triggers will help you create an event at which creates a community bond, boost guests self-esteem, and make them eagerly raise their paddles to generously support your organization and its mission.

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The Psychology Behind Events (When They Start Again) - The NonProfit Times

Neuroscience course to fill ‘gap’ in teacher training – TES News

A headteacher is pilotinga new course ineducational neuroscience, designed to fill a perceived "gap" in conventional teacher training.

The Neuroscience for Teacherscourse, which will recruit up to 30 qualified teachersfrom state and independent secondary schools, will focus on how childrens brains develop throughout the teenage years.

Julia Harrington, head of Queen Annes School in Caversham, Berkshire, has commissioned Professor Patricia Riddell, a neuroscience specialist at the University of Reading, to design the course, which will be piloted in 2020-21.

Neuroscientist:What teachers need to know about the teenage brain

Watch: How teenagers' brains work

Feature:Why where you learn matters

The free course will involve six interactive days of workshops across the next academic year, on topics includingmotivation and engagement; learning and technology; memory; decision-making and leadership; mental health and wellbeing; and action research project planning.

There has been rising interest in recent years in the way neuroscience can be applied in the classroom.

However, some academics doubtthat meaningful links can be drawn between neuroscienceandeducation.

Ms Harrington said the application of educational neuroscience and cognitive psychology at her own school had led to improved emotional wellbeing and academic performance.

She added:"I believe that learning to become a teacher is incomplete without some understanding of whats happening in the teenage brain.

"So I asked Professor Patricia Riddell to design a completely new course to fill that gap in conventional teacher training."

Teachers wishing to take part must have between threeand fiveyears experience, and will also need the support of their school head.

They will be recruited over the spring and summer of 2020 to take part in the pilot, which will start in September 2020 and finishin June 2021.

The course will be free to participants as training costs will be covered by Ms Harrington's research centreBrainCanDo.

Professor Riddell said: "I am very excited to be given this opportunity by Julia and BrainCanDo to bring my expertise to the educational sector.

"There is so much that we now know about how childrens brains develop that can help teachers, both by designing teaching and learning which works with our brains and increasing motivation in children to learn."

Ms Harrington added: "We used to think that the brain stopped developing at age 11 but we now know that it continues to adapt well into adolescence.

"Its obvious to me that both classroom teaching and pastoral care need to reflect this aspect of childrens growth."

Headteachers interested in nominating a teacher to take part in the pilot should contactinfo@braincando.com.

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Neuroscience course to fill 'gap' in teacher training - TES News

To Flatten the COVID-19 Curve, Target the Subconscious – Scientific American

Even now, as fears about COVID-19 have grown across the world, there are still people ignoring warnings. Theyre gathering in crowds on beaches or bars (those that are still open). Theyre not washing their hands nearly enough. Despite the pleas of government and health officials, some people seem to be doubling down on social gathering rather than social distancing. And because of how viruses travel, these people are endangering the rest of us.

Why do some people believe the response to the coronavirus is an overreaction, while others think it doesnt go far enough? Why do some arm themselves with masks and disposable gloves and hoard toilet paper while others refuse to change their routine? The answer doesnt lie simply in their sources of information. It involves something deeper: the subconscious, where the vast majority of decisions are made.

As Yale psychology professor John A. Bargh put it, When we decide how to vote, what to buy, where to go on vacation and myriad other things, unconscious thoughts that were not even aware of typically play a big role. A study led by John-Dylan Haynes of the Bernstein Center for Computational Neuroscience Berlin showed that brain activity can reveal a persons choice long before he or she is even aware of it. Neither rebellious nor compliant behavior is intentional; they are automatic. These two different cohorts are playing out a behavior thats predetermined in their subconscious, unknown even to themselves.

UNDERSTANDING THE BRAND CONNECTOME

Years ago, psychologist Daniel Kahneman won the Nobel Prize for his work showing that the human mind has shortcuts (heuristics) that overpower rational decision-making. Last year in Knowledge@Wharton, psychology and neuroscience professor Michael Platt and I shared our discovery about what lies inside those shortcuts: intricate networks of brand associations accumulated over time, years in the makingsome going as far back as childhood. We call these networks the Brand Connectome, named after the human connectome, a map of the brains neural connections.

To win people over to a company, product or cause, marketers must fill their Brand Connectome with positive associations. Over 30 years in marketing, Ive found that when a Brand Connectome has more positive than negative associations, and more positive associations than its competitors, people will switch to that brand.

These associations can be conveyed through cuesparticular words, images, sounds and so on. This is why, for example, an M&M's ad featuring Danny DeVito surrounded by a pool of melted chocolate was so successful. This metaphor instantly associated the brand with bliss and superior, creamy chocolate.

Just as we all have connectomes for brands, we also have them for political campaigns, causes and more. And we have connectomes for health care compliance.

THERAPEUTIC NONCOMPLIANCE

Unfortunately, efforts to improve health care compliance have a long and rather unsuccessful history. A team of researchers dug into more than 100 studies on therapeutic non-compliancepeople who dont follow doctors recommendations. Efforts to make medications affordable and easy to take werent enough. Why not? These measures did not address psychosocial factorsunderlying beliefs, attitudes and motivations. And in general, the lowest levels of compliance with doctors directions came when patients were asked to change their lifestyles. Only a paltry 20 percent to 30 percent of patients did so.

In the case of COVID-19, everyone, not just patients, is being asked to change their lifestyle behavior. Its the most comprehensive behavior-change initiative in modern history. No wonder so many people remain resistant.

To change minds, officials need to market their message directly to peoples instinctive decision-making mechanismtheir Corona Connectome.

MARKETING COMPLIANCE

Peoples responses to coronavirus prevention are shaped by cumulative subconscious associationsfor example, whether their parents approach to health and safety was protective or carefree; whether they lost loved ones to fatal disease; whether they themselves have suffered from serious illness.

To change the connectome of people who are noncompliant, officials need to pack their messages with the right cues that help leverage positive associations quickly. Connect COVID-19 precautions to aspirational movements, like community spirit and local pride, that already exist in the subconscious. Leverage peoples desire to do the right thing for others in all aspects of their lives.

Use imagery of famous people in protective gear delivering food to seniors doors. Make adherence, from using antibacterial wipes to staying home, a badge of honor. Feature rap artists, celebrity athletes and movie stars telling people to shelter at home. Use metaphors, like the proactive treatment of a small cancer cell, to explain the importance of stopping the virus as early as possible.

Leaders must act quickly. With each passing day, even people who have been heeding the warnings might become tempted to resume normalcy. It will take a steady influx of messaging to shift peoples behavior. The good news is that if you appeal to the subconscious with the right messages and cues, instincts can be changed quickly and we can flatten the curve.

Read more about the coronavirus outbreakhere.

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To Flatten the COVID-19 Curve, Target the Subconscious - Scientific American

Smell changes memory processing and could treat trauma – Medical News Today

Smells can reinvigorate old memories in a way that doctors could use to treat memory-related mood disorders, suggests a study in mice from Boston University.

The nature of memory is one of the biggest mysteries of neuroscience. Memories are at the basis of who we are, and how the brain processes and consolidates them is the subject of work around the globe.

A recent study from Boston Universitys Center for Systems Neuroscience has shown the power of smell in recalling memories, challenging a decades-old theory in the process.

The new research appears in the journal Learning and Memory.

The hippocampus a small brain structure shaped like (and named after) a seahorse is critical in the process of memory formation.

People with damage to the hippocampus are often unable to form new memories, and the region is also one of the most vulnerable in Alzheimers disease.

Experts think that when memories first form, the hippocampus processes them and captures rich, contextual details in the memory.

Over time, and particularly during sleep, the prefrontal cortex, or front of the brain, processes the memory, where many of the details embedded by the hippocampus become lost.

Scientists call this the systems consolidation theory, and it helps to explain why memories become fuzzier over time.

According to this theory, recalling a memory shortly after it happens involves activation of the hippocampus, whereas remembering an old memory involves activation of the prefrontal cortex.

This is because the same brain cells that are active when a memory forms reactivate when a person recalls that memory.

However, there are some inconsistencies with this theory. Some people remember old memories vividly, something familiar to people who have post-traumatic stress disorder (PTSD).

And smells, which the short-term memory area of the hippocampus process, can trigger memories from years gone by.

To test this theory, the new research tied memory to smell in mice.

The researchers created powerful memories in the mice by giving them a series of harmless but jolting electric shocks while inside a container. While receiving the shocks, the scientists exposed half of the mice to the smell of almonds.

The following day, the researchers returned the mice to the container and exposed the same mice to the almond scent again.

In both groups of mice, the region of the brain associated with short-term memory, the hippocampus, was active. This suggests that all the mice remembered the shocks from the day before. This is in line with the systems consolidation theory.

However, when the researchers performed the same recall experiment 21 days after the shock, all the mice showed some activity in the prefrontal cortex. However, the hippocampus showed significantly more activity in the mice who smelled the almonds than those who had the shock alone.

This was a surprise for the researchers, who were expecting to see more activity in the front part of the brain in all the mice.

[This finding suggests] that we can bias the hippocampus to come back online at a time point when we wouldnt expect it to be online anymore because the memory is too old, explains Steve Ramirez, assistant professor of psychology and brain sciences and senior author of the study.

The finding suggests smell can reinvigorate memories with detail, via the hippocampus.

The finding has the potential to revolutionize scientists understanding of memory processing. Although scientists still need to work out the finer details, the study suggests that the theory of the systems consolidation does not always hold true.

Beyond the academic interest, these findings could pave the way for new tools to treat mental health conditions caused by traumatic memories, namely PTSD.

Now that we know that odor can shift memories to become more hippocampus-dependent, we could potentially develop strategies that engage or disengage the hippocampus. And then we could integrate some behavioral or drug-based approaches to bring the hippocampus back offline if our goal is to permanently suppress a fear memory,

Steve Ramirez

Most current approaches to treat PTSD try to suppress or dampen the traumatic memory, but crucially this only works when a person can recall the memory first. Using smells to spark memories could, therefore, be a significant pathway to treatment.

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Smell changes memory processing and could treat trauma - Medical News Today

Why space for reflection is critical in learning and development – TrainingZone.co.uk

Honestly Nigel, theres never a minute! This was a heartfelt comment from a senior learning leader a month or so ago when I happened to bump into her at an event. She was describing not just the challenges, but also the incredible excitement she was feeling, because her role in the organisation had shifted from the periphery to centre stage.

Perhaps for the first time, lots of people were listening to her and seeking her advice, and, above all, senior executives were investing willingly in the development of their staff.

This is genuinely exciting if you are a learning leader. Who would not want to have the whole organisation finally understand the direct business benefit of investing in staff? To play a part in keeping the whole organisation more agile, engaged and able to cope with the challenges of the present, as well as building resilience for the future was, indeed, a privilege.

There is something very powerful about being engaged, and working at the centre of what is driving an organisation. And because most people want to succeed and fulfil the promise and the trust that has been invested in them, they do not rest. Each day becomes a hive of activity and decision making.

I now want to pour a little cold water on that scenario. I worry about this frantic drive to do stuff! What we have known for at least 30 years is that taking stock is vitally important if we want to remain effective and relevant.

This idea is reinforced on a regular basis by new neuroscience research. Reflection is good for the brain and good for the individual. The truth is that the very elements of my colleagues success in that exciting present presages the potential failure of her strategy in the near future.

The plaudits she is getting now can easily turn into brickbats, when what she expects to happen, does not occur. Or where expensive investments that she engineered did not deliver the benefits promised or the hoped for increases in productivity. Before you get caught up in a whirlwind of activity please pay attention to these three simple points.

If you are not actually taking the time to look at what you are doing in a critical way, you run the danger of making assumptions that do not work, or work for a little bit and then fail.

In the 1990s Donald Schon published a very important book called The Reflective Practitioner. In this book he argued that the age of the expert, who knew everything about a topic, had come to an end. The environment was too complex for expertise gathered in the past to be wholly relevant in the present. Does that sound familiar?

Schon was arguing for a different kind of practitioner to reflect the modern age. This person spent more time enquiring, asking questions, and exploring and validating his or her domain than telling people what to do or providing ready-made solutions.

A critical part of this was the ability to reflect, not only looking backwards on the action that had taken place, but also to reflect in action.

This was about having the wherewithal to change an approach because the circumstances or the context had changed. He likened this process to the difference between standing on a hill and surveying everything from far off, where it all looks neat and logical, and moving down from the hill into the swampy lands below where its hard to make your way, and hard to see exactly the direction to take.

The point is that it is in the swampy lands below where your organisation lives. We do not work day to day in an abstract theoretical way. We have to make pragmatic decisions.

Some people have disagreed with Schons stark distinction between reflecting on action and reflecting in action. But the point is, if you are not actually taking the time to look at what you are doing in a critical way, you run the danger of making assumptions that do not work, or work for a little bit and then fail.

Neuroscience has taught us what most of us pragmatically know to be true: that the brain only learns when we stop for a second to process information.

After the Vietnam war, the US military changed the whole philosophy of leadership in the field, for very good reasons. And, out of that, emerged something called the after action review, which would even take place in the middle of a combat zone.

The review looked at every activity and engaged a simple process to review what worked, what did not work, and what could have been done better. This was all logged, and action was taken in light of the review. These reports were widely circulated, to not just the group involved, but to anybody who could benefit.

How many people in learning sit down quietly and conduct regular after action reviews? This can be about a relationship with a supplier, a relationship with an executive, or the implementation of some kind of programme. If the results are shared, the whole team learns and gets better and better. They all adapt and adjust as the environment changes.

Neuroscience has taught us what most of us pragmatically know to be true: that the brain only learns when we stop for a second to process information, and pause from cramming more and more information into our heads.

An example of this process is a doctoral program I have been involved with at the University of Pennsylvania in Philadelphia. Over the years since inception we have systematically cut back the amount of content, in favour of reflection and discussion. Integrating the learning with various techniques for reflection and discussion has now become a core part of the programme. Even walk/talks are now embedded in the learning model.

This will NOT happen by itself. Immediate pressures will overwhelm the best of intentions. You have to take active steps to create some space in your life and your work to turn this into a habit.

Here are some ways to start this process:

Build slowly. Start with 15 mins per day. If you can do that consistently for two weeks, you will start to build a habit. Once the habit is established you will be able to find extra time to complete this task. If you have not established the habit, you will only sporadically achieve the space to reflect, and then it will become more and more sporadic and eventually you will return back to where you started. Pick a time when you can shut off. Develop a nagging voice in your head, and then listen to it.

Have a structure. Maybe just three questions to answer about what more information you need; what went well, and what went badly; what have you learned this week? And then decide with whom you will share these insights.

Write down your conclusions even if you do not act on them immediately. Keep them separate in a notebook or a file so you can go back later to review and prioritise. And guard the insights as bright ideas that will emerge. They will be gold dust at the right moment.

Share your actions and build support for reflection across your whole team. Once you have worked out how to do it, make it a team habit, and a team process. The learning is multiplied many times over as is your impact and effectiveness. It will also strengthen the team and share their learning.

Do not give up. Work on it, find space and embed the process. It is at the heart of agility and resilience.

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Why space for reflection is critical in learning and development - TrainingZone.co.uk