Category Archives: Neuroscience

The Incredible Human Mind is a Direct Portal to the Almighty Creator – Benzinga

LAS VEGAS, April 24, 2020 /PRNewswire-PRWeb/ -- Author Nancy J. Woolf addresses some perceived inconsistencies between intellect and spirituality in Conscious Matrix: Our Portal to God ($16.49, paperback, 9781630508586; $26.49, hard cover, 9781630508593; $8.99, e-book, 9781630508609).

Woolf spend over 30 years teaching and researching neuroscience and quantum mind theory, and she encountered many scientists who challenged people to choose between science and religion. But what if we didn't have to choose? What if the two fields of study were actually in agreement all along?

"Paradoxically, the more we understand science--how the conscious matrix within the brain is wired and how energy and matter converge at the smallest scale--the more we prove God truly exists, and that our brains evolved first and foremost to experience of God," said Woolf.

Nancy J. Woolf was an Emeritus professor in the UCLA psychology department and holds a Ph.D. in Neuroscience from the UCLA School of Medicine. Now retired, she enjoys dancing, traveling and the culinary arts.

Liberty Hill Publishing, a division of Salem Media Group, is a leader in the print-on-demand, self-publishing industry. Conscious Matrix is available online through amazon.com and barnesandnoble.com.

SOURCE Liberty Hill Publishing

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The Incredible Human Mind is a Direct Portal to the Almighty Creator - Benzinga

The Idea of the Brain Review: The Thinking Machine – The Wall Street Journal

Matthew Cobb, a professor in the School of Biological Sciences at the University of Manchester, a man whose erudition spans biology, neuroscience, psychology, genetics and other discipline-blurring specialties, wastes no time in telling us what we arent going to learn from his book. In 1665, he begins, the Danish anatomist Nicolaus Steno put forth a revolutionary idea about the brain that has been guiding researchers ever since: To understand what the brain does and how it does it . . . we should view it as a machine and take it apart to see how it works. And take it apart they have: We can now make a mouse remember...

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The Idea of the Brain Review: The Thinking Machine - The Wall Street Journal

Feast or famine: The effect of marijuana on weight – The Spokesman-Review

Your new years resolution for 2020 was to lose weight. And this time, you really are committed to making it happen.

But heres the dilemma: When trying to drop the pounds, do you stop using pot because it gives you the munchies or do you increase your intake because, for some, it acts as an appetite suppressant?

It depends, according to Dr. Jon Davis, Ph.D., assistant professor at Washington State Universitys Department of Integrative Physiology & Neuroscience.

(Cannabis potential to act as an appetite suppressant) hasnt been well studied at all. Theres not enough information to make a statement one way or the other on it, said Davis, who specializes in feeding and drug addiction at WSUs Alcohol and Drug Abuse Research Program.

What Davis does know is that a lot depends on you when it comes to marijuana and its effect on body mass. Your metabolism, health, age, sex, the strain of cannabis you use, how much sleep you get, and other factors all play in to whether marijuana contributes to your personal weight loss or gain. Davis cites a 2014 study, published in the journal Innovations in Clinical Neuroscience, that looked at two subject groups who used marijuana: the general population and those with disease-based anorexia. The low-weight group gained weight while the general population group did not.

This may leave you curious if theres any truth to the old case of the munchies stereotype. Davis acknowledges that marijuana affects the mechanisms that trigger hunger in our brain and can definitely cause you to raid the pantry. He says the munchies are a delayed effect of cannabis, though.

One thing weve noticed in our lab is when you give cannabis to an animal, it doesnt immediately go over and start eating. Its not until about an hour later that they get hungry and then that only lasts two or three hours, so its a delayed effect.

Two of the main effects of marijuana use are euphoria and appetite stimulation. Davis believes euphoria initially overpowers the bodys hunger response. But once the euphoria starts to wear off, users notice that they are hungry. Only lasting a couple hours usually at most, that hunger may not initiate a large enough calorie intake to make a lasting impact on body weight.

But for chronic users of marijuana, wouldnt that pattern repeated over and over again eventually result in weight gain? Davis says cannabis use can be like alcohol use people who drink regularly are affected differently than those who drink rarely or occasionally.

Its been shown that people who use cannabis regularly have reduced receptors for cannabinoids, so a tolerance develops.

Cannabinoids are compounds found in the marijuana plant; THC and CBD being the best known. So if youre a regular consumer, you may no longer get the munchies, or to the same degree, that new or occasional users do.

While that could be good news for the waistlines of pot lovers, continued use of weed still may not be great for your health.

It definitely can impact blood pressure, cholesterol and triglyclerides (a kind of fat found in the blood stream), said Davis. A nerve called the vagus nerve controls heart rate. Stimulation of that nerve (such as with marijuana use) increases blood pressure.

While cannabis use may not make you gain weight, can it help you lose weight?

Another question with an unclear answer. Some growers are now marketing marijuana strains specifically for weight loss, usually those with tetrahydrocannabivarin (THCV), a lesser known cannabinoid.

While THC is known for stimulating appetite and is responsible for the munchies, THCV is believed to act as an appetite suppressant. CBD is believed to have a similar effect, only without the euphoria that comes with strains that contain THC.

Again, though, Davis stresses that there isnt enough knowledge at this time on how effective either THCV or CBD are as weight loss proponents. With cannabis still illegal at the federal level, few studies have been completed, due to a lack of both funding and time.

You have to have a Schedule 1 license to have the plant and that takes 18 months. Were built off publication and dont have the luxury of that kind of time, said Davis.

He also says that is beginning to change and WSU is one of the only labs in the world that has looked at marijuana use in conjunction with feeding.

But we still need time to understand the physiological and plant-based mechanism.

Tracy Damon is a Spokane-based freelancer who has been writing professionally for 20 years. She has been covering i502 issues since recreational cannabis became legal in Washington.

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Feast or famine: The effect of marijuana on weight - The Spokesman-Review

National scholarship will allow student to pursue graduate studies in early reading cognition – University of Wisconsin-Madison

When Lauren Schilling studies the statistics on early literacy, she knows more must be done: Children who lack foundational reading skills fall behind academically, and the gap grows exponentially over the years.

As an undergraduate at UWMadison, Schilling is already tackling the problem. Her research investigates how first-grade phonics curricula lay the foundation for important third-grade reading benchmarks.

Now, as the recipient of a major national scholarship, Schilling will receive substantial financial assistance to continue her research in graduate school. She is among 18 college juniors nationwide selected to receive a 2020 Beinecke Scholarship, which provides $34,000 for graduate study in the arts, humanities or social sciences.

In graduate school, Schilling hopes to work with researchers who are developing novel literacy interventions and exploring cognitive mechanisms that predict individual differences in reading.

The Beinecke Scholarship Program was established in 1971 by the Sperry & Hutchinson Company to support the graduate education of students with exceptional promise. UWMadisons last Beinecke Scholars were Bront Mansfield (art history and English, 2014), Joanna Lawrence (anthropology, 2013) and Asad Asad (political science, 2010).

Schilling, of Minocqua, Wisconsin, is majoring in psychology and education studies and pursuing comprehensive honors in the liberal arts and psychology. As the youngest of four children, she spent bedtime curled up between her brothers as their mother read to them, she says. Her affection for the written word continues and informs her research and advocacy.

Reading allows us to immerse ourselves in circumstances historically or geographically distant from our own and open our minds to new perspectives, she says. Every child deserves to read.

Schilling currently works with Vilas Professor and Donald O. Hebb Professor of Psychology Mark Seidenberg in the Language and Cognitive Neuroscience Lab, where she is a project manager.

Our project is the very first cross-comparison of reading programs using computational models, Schilling says. We are analyzing two major reading curricula that reach tens of thousands of American children annually.

By identifying instructional practices that are effective at helping children learn to read, Schilling hopes her research will help eliminate educational opportunity gaps for students from low-income backgrounds and those with learning disabilities.

I want to help children to love reading by enhancing their educational language environment, she says.

Reading allows us to immerse ourselves in circumstances historically or geographically distant from our own and open our minds to new perspectives, Schilling says. Every child deserves to read.

Faculty Director of the Letters & Science Honors Program and Griebsch Bascom Professor of German Sabine Gross remembers Schilling seeking her out as an honors freshman to interview her about her reading research.

I learned that for years it had been Laurens goal to conduct research on reading in order to improve educational equality and provide opportunities for learners, Gross says. In her sophomore year, she engaged me in a lengthy discussion about the relevance of a number of factors she was considering in choosing a lab for her graduate studies. I have rarely encountered a student of Laurens caliber who has pursued the goal of a career in research with such early and single-minded dedication.

Schilling has been a research assistant with UWMadisons Learning, Cognition and Development Lab and with the Educational Neuroscience Lab. Additionally, she is working with Professor Annalee Good, a researcher and evaluator at the Wisconsin Center for Education Research, to develop an after-school phonics curriculum for young students from low-income backgrounds in Madison.

Schilling has augmented her academic research with work as a volunteer middle-school literacy tutor through the Schools of Hope program in the Madison School District and as a member of Badgers Reach Out and Read, a student organization that promotes early literacy.

In addition to institutional awards from the Psychology Department and the College of Letters & Science, Schilling is the recipient of a $10,000 Herb Kohl Student Excellence Scholarship, a statewide award for leadership, citizenship, school and community involvement, and academic achievement.

In graduate school, Schilling hopes to work with researchers who are developing novel literacy interventions and exploring cognitive mechanisms that predict individual differences in reading.

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National scholarship will allow student to pursue graduate studies in early reading cognition - University of Wisconsin-Madison

As Remote School for Texas Kids Continues, Try These STEM Learning Resources – UT News | The University of Texas at Austin

With Texas' governor among those declaring that K-12 schools will remain closed through the end of the school year, many families and teachers are looking for resources to support learning from home.Several outreach programs in the College of Natural Sciences and at UT Austin support STEM learning from afar. Here are a few to check out.

Neuroscience: UT Brainstorms

The Department of Neuroscience at the University of Texas at Austin has had nearly three seasons now of the popular lecture series UT Brainstorms. The entire archive is available online for on-demand viewing.

Marine Science Institute: Daily Virtual Ocean Science Activities

Six days a week at 1 p.m., UTMSI brings a new offering for science lovers care of the educational program staff. From science talks to virtual beach-combing to hands-on science exploration activities to calming nature-inspired videos, take an after-lunch break each day on the UTMSI Facebook page.

Astronomy: Seeing Outer Space Online

Enjoying astronomy in action at the Observatory can happen from the comfort of your home. UT Austin's McDonald Observatory offers opportunities to explore the West Texas mountain observatory, look up into the sky with members of the K-12 Program Team during a videoconference, and enjoy guided night-time YouTube livestreams with a view from one of the observatory telescopes into deep space. Augment your exploration this week by spending time with UT Astronomers in Austin, involved in a special virtual Astronomy on Tap this week honoring the 30th birthday of the Hubble Space Telescope.

Nutrition: Cook 'Em

Turn mealtime into a learning opportunity with these healthy video recipes created by UT Austin nutrition students. Based in the in the Department of Nutritional Sciences, Cook 'Em is an online collection of student-produced instructional videos designed to promote healthy eating through the application of nutritional science in daily life.

Biodiversity: Falcon Cam

The University of Texas Tower is home to a female Peregrine Falcon, nicknamed "Tower Girl." An urban predator who lives in Austin year-round, she can be seen swooping down at remarkable speeds to find her prey. A live camera allows budding scientists and fans to learn and observe by tuning in to her nest box at the top of UT's iconic tower.

Environmental Science Institute: Hot Science Cool Talks

Get a front row seat to world-class research by accessing Hot Science Cool Talks' online archive. This nationally recognized series allows leading researchers from The University of Texas and other prominent universities to share their passion about science, technology, engineering and math with the general public.

Priscilla Pond Flawn Child and Family Laboratory: Tours, Stories and More

UT specialists in early education based in the Department of Human Development and Family Sciences have compiled resources to support families learning with young children. Find a trove of resources from around not just Texas but the world sure to be of interest for toddlers, preschoolers and kindergarteners.

Texas Memorial Museum: Fossil Fun and Other Science

With its doors currently closed to the public, TMM has begun offering new science activities for museum-goers on its social media channels. In one of the first offerings, in conjunction with researchers from the Jackson School of Geosciences, you can download a print and play fossilization game.

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As Remote School for Texas Kids Continues, Try These STEM Learning Resources - UT News | The University of Texas at Austin

Here’s How to Lead Successful Change – Thrive Global

Change comes in all kinds of forms, from the small and annoying to a global pandemic. Any imposed change compels us to act, whether we want to or not. But in which directions will change move us? Todays leaders are called to unprecedented responsibility in response to fatigued teams and shattered norms. How do you manage your team through such change? Where do you need support?

Because change will continue until new norms are established, handling the crisis is an ongoing challenge. Many are drawing on principles in change models to help guide them. The Change Quest Model is based on the neuroscience of change, and maps disruption and employee motivation as well as offering tools for guidance.

The neuroscience of change is helpful in understanding what happens to us, biologically, when we go through change. Further, we can assess the impact of change by observing how long it takes to get acclimated to the new normal and how much disruption it creates in our daily lives.

The Brain During Change and How to Support It

Several brain structures can get activated by change. And I see all of them happening to us now. The amygdala sees change as threatening and tends to respond with fear and anxiety. Thats certainly happening to me. Check.

The entorhinal cortex creates mental maps of our physical spaces and social networks, and if change impacts either or both of those, it has to do some heavy lifting. Thats happening tooCheck.

The basal ganglia turns repeated behaviors into habits that we can automatically do without thinking. Some changes require us to not only develop new habits that are awkward and uncomfortable at first, but also require us to leave behind well-grooved and easy habits.

Feeling this tooCheck.

And we can also experience change fatigue when change is coming faster than our ability to adjust. AbsolutelyCheck.

When it comes to triggers affecting work and adapting to change, the COVID-19 crisis is hitting every one. If youre a manager or leader, you play a critical role during this massive shift. Work with your teams to calm the amygdalas fear and anxiety trigger. Communicate often, being as transparent as you can. In the absence of information, the brain is designed to fill in the worst case scenario so provide the information you have, again and again, exuding as much calmness as you can muster.

Help the entorhinal cortex settle in as your employees are dealing with newly reshaped work settings. Support them by encouraging them to set up a working area at home and help people stay connected to their colleagues through video-based coffee breaks or lunch dates. People need to stay connected to the relationships that matter and not just in back-to-back meetings. On that note, dont schedule back-to-back meetings. Give people 10-15 minute breaks between them because video conferencing takes its own kind of concentration that is exceptionally tiring in long stretches, not to mention the strain it puts on the body.

In terms of the basal ganglia, all of us are learning new habits so give employees time and space to develop them. It takes, on average, 40-50 repetitions of a new behavior for the basal ganglia to turn it into a habit that we dont have to think about. Until then, we can make mistakes and get frustrated with being awkward at something. You can help by guiding people through using the new tools and methods, expecting some errors as people learn, and making it safe to ask questions. You can have a huge impact by acknowledging effort and progress. Right now, every small success matters.

And when change fatigue hits, call on the best in yourself and your team, to take breaks, help each other out, and remember that it wont feel new forever.

As adaptation continues, and new norms settle in, the Change Quest model can help you mount successful, smaller, but still crucial changes within the broader circumstance. From the various change initiatives I have witnessed in my years of consulting, four factors consistently influence outcomes. The first two:

On a regular day, these two factors allow us to plot the impact of different types of changes into quadrants. For instance, changes that are low disruption and require a low amount of acclimation time fall into the bottom-left zone (green): changes that are easy to adjust to quickly.

The upper-right zone (red) represents changes that are high in disruption and time to acclimation. This is the zone nearly all of us are inhabiting in response to the global COVID-19 outbreak or any change that requires a lot of effort over a long time including mergers and acquisitions or launching a new product, and on the home front, remodeling your home, or dealing with a long illness and/or death.

Use this matrix to consider the impact proposed changes will have on your employees. Its a good predictor of how much resistance and upset a change is likely to cause. Right now, everyone is pretty maxed out just managing the day to day shifts so if you can, postpone or revise other changes that your organization was planning to launch in the next few months.

In addition, there are two more factors that mark how employees respond to change, significant because they shape key psychological aspects of how humans are wired.

3. Individual choice: Do the employees choose the change or will it be put upon them?

4. Desire: How much do the employees want the change, or again, is it being put upon them?

Choice and desire impact our emotions, attitudes, and motivations. Its easier for people to get onboard with changes that they choose or want, even when the change represents more disruption or longer acclimation time. Again, these two factors can be mapped against each other as a grid against yes or no for both choice and desire. Using both matrices is recommended, to really assess the impact of a change.

When people both desire and choose a change (yes and yes), they are likely to be happy about it and experience it with enthusiasm and energy. Their motivation looks like theyre running toward it and celebrating the win. If a person really wants a change that they did not choose, theyre likely to see it as an unexpected but good opportunity. Motivation is more like walking toward it, feeling good about embracing it.

A change that is not wanted but is chosenis tricky and usually represents some kind of should or intentional sacrifice, like accepting a lower position rather than being laid off. It might feel like trudging along and often includes feelings of resentment or disappointment. Social distancing and sheltering at home are examples of this kindwere not excited about it but were doing it for the good of our neighbors, family members, and healthcare workers. Collectively, we are trying to make the best of it during these trying times.

Finally, changes that people did not choose nor want. Obviously, without natural motivation people feel a lot of resistance toward this imposition, perhaps needing others to push or drag them along. Depending on how badly people feel about it, they might even actively fight the change, digging in their heels.

We can agree that people did not choose nor did they want this global pandemic (no and no), which means we are more likely to resist this upheaval, and find it more difficult to lean in to what is being asked of us. And yet we will. While humans are wired to resist change, we are also incredibly adaptive. Were already adapting. You can see examples everywherepeople of all ages are practicing new kinds of hygiene and social distancing, medical professionals are innovating solutions while fighting for lives on an hourly basis, and leaders are making rapid decisions and taking unprecedented actions.

As a manager or leader, its important to take all these factors into account when considering how to best support your employees, customers, and communities. Every single person on the planet is now dealing with the stress of these difficult changes that we did not choose nor want. Some are navigating the fear of the disease itself, caring for loved ones or dealing with terrible loss. Some are suddenly unemployed and are struggling to find the basics of food and shelter. Some are homeschooling their children while learning how to work from home. Here are some strategies you can use to help take care of your people:

First, dial down your expectations. People are anxious and exhausted. This means that people are not going to be as effective or productive as they usually are. When issues of survival are triggered, the reptilian brain takes over, which makes it harder for people to access their higher order thinking skills like logical analysis and creativity. People are going to be more easily annoyed and triggered, so you will likely see more conflict. Help them by taking off some of the pressure. Dont expect people to produce at the same level as before. Focus in on the most critical elements and let the other stuff slide for a bit. Push out deadlines, reduce bureaucracy, make meetings shorter, and create more breaks.

Second, have patience and compassion. As a manager or leader, you play a central role in the tone of how people see and experience what is happening around them. When people are under stress, they have higher needs for information and communication. You will likely find yourself answering the same questions over and over. Breathe and answer them again. You will also be dealing with peoples emotions on a daily basis, especially since people are struggling with the adjustment to this new, and ever changing situation. When people are sad or angry or scared, just breathe. And connect with them on a human level. You dont have to have all the answers for someone to feel seen and heard.

The two most powerful words when were in struggle are, me too.

Third, dial up your own self care and encourage others to do the same. During times of stress, we need self care more than ever. Make sure you are getting enough sleep, eating nutritious foods, and moving your body. Limit how you watch the news since it can trigger our amygdala and fight/flight/freeze response. If you can, try doing a mindfulness practice like meditation or yoga. And allow yourself to relax too. Whether its reading, binge watching shows, or some other activity, its important to take a break from all the intensity of what is happening. You need to be in good shape to help others so by doing that for yourself first, you will have more patience and compassion to share. And you give others permission to take care of themselves too.

Leaders at every level play a central and very powerful role in how we each respond to and move through change. By the time this crisis is over, we will have seen several examples of leaders who provided extraordinary guidance, and others who unwittingly did unfortunate damage.

Whats your go-to strategy for managing change? Share with us in the comments!

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Here's How to Lead Successful Change - Thrive Global

Opinion | Covid curves and charts cannot do what evocative appeals can – Livemint

How will people behave once the Great Lockdown is lifted? Will they be cautious enough to maintain physical distance and wear masks while they are in public? A vaccine for covid -19 is several months away. So the best solution to mitigate the further spread of the viral disease is for people to voluntarily adopt a precautionary set of behaviours. But, if what we saw when Floridas Jacksonville Beach or Keralas Thiruvananthapuram roads were opened for few hours is anything to go by, we have a lot to worry about. Why is it that despite experiencing one of the worst crises in human history, many people are still unwilling to adopt simple precautions? Blame it on a failure of the communication strategy used so far during the pandemic.

The latest and most sophisticated knowledge from the fields of medicine, artificial intelligence and data analytics have been used to tackle the pandemic. But the communication strategy around it was based on an outdated understanding of human behaviour. It was developed based on the belief that as long as we provide detailed information on the pandemic and build awareness of the appropriate behaviours to adopt, people will fall in line. This is a strategy that pays tribute to Homo economicus, the rational species.

Latest learnings on cognitive neuroscience and behavioural economics provide us many new insights into how humans relate to risk. According to Neil Weinstein, professor emeritus, Rutgers University, US, people have an optimistic bias vis--vis their personal risk; when it comes to potential harm, such as disease or catastrophe, people think that others are more likely to be affected than them. Optimism is the greatest when people have little personal experience of the hazard, the chances of its occurrence are low, and when hazards are thought to be controllable by oneself. The asymptomatic nature of the covid contagion made it even harder to relate to its risk. Thanks to these behavioural vagaries, many people could not fully perceive its real risk.

However, some did panic, and in their attempts to keep pandemic panic at bay, the authorities focused on keeping stress levels in check. This communication strategy ended up mollycoddling the general public. Many ended up thinking that being infected with the virus is like having a high fever and cough. The casualness of those congregating in public places is proof that most people havent grasped the real risk of this pandemic. How do we make these people understand its seriousness and behave more cautiously?

The worlds situation is such that all developments of the human race have proven useless in front of a virus. This is similar to the days when humans had not yet invented any tools to defend themselves from predators in the wild. Evolutionary psychologists would remind us that in those days, basic human nature was the only help we had against threats. Today, that very human nature could be evoked to protect the human species from the covid pandemic.

Learnings on neuroscience inform us that emotions are an integral part of all human decisions. For human beings, emotions serve as the first screen for all information received. The emotion of fear was our species best protection against any danger. It has saved far more lives than even modern medicine. While developing strategies to protect ourselves from the covid outbreak, it is worth bearing in mind that the basic construct of the human brain places emotions before reason.

According to neurobiologist Lilianne Mujica-Parodi, You dont want someone without a fear response at all." In times of danger, fear is our best friend. Its a chemical reaction, a signal to pay attention to a threat. When we get scared, our bodies react physically and triggers our fight-or-flight response. According to Neal Miller, a behavioural psychologist, fear is an internal energizer of behaviour, and a scared person always tries to get away from the fear-arousing stimulus. If this pandemic did not make people display this avoidance response in public places, it is probably because they did not perceive any threat from the person next to them.

Most of the communication put out on the current pandemic has been in the form of graphs, numbers and stick figures. Authorities have been speaking about flattening the curve", not saving human lives. As thousands more got afflicted, human lives have become just another dot on a graph.These lifeless graphs do not generate any emotion among those who are not statistically inclined enough to grasp what they reflect at a glance. Emotions are usually generated by vivid, real-life stories of individuals. The Vietnam photograph of a naked girl running away after a napalm bomb attack captured all the horrors of that war in a single frame. If covid graphs are replaced with stories and images that capture the emotional intensity of this tragedy, we would perform better.

We could encourage people to hold their breath for 20 seconds to get them to relate to the heaviness in the chest of those infected with the coronavirus. Images of sportspeople who got affected by this disease should be played up to alter youth attitudes. Its also clear that the crisis would have held stronger emotional appeal if the communication focused on families, not just individuals. All these initiatives should be topped up with a strict instruction to wear masks in public, which offers visual proof that these are not normal times. We cannot expect people to take precautions in the absence of adequate levels of apprehension.

This strategy is not without negative side effects, though. Feelings of fear could reduce the chances of people voluntarily asking for covid tests. It could also lead to increased chances of the ostracization of those infected. These issues have to be tackled through appropriate communication too.

The covid pandemic reminds us that to achieve behavioural change among a significantly large number of people, the emotional language of saving lives" is far more effective than the rational communication of flattening the curve".

Biju Dominic is the chief executive officer of Final Mile Consulting, a behaviour architecture firm

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Opinion | Covid curves and charts cannot do what evocative appeals can - Livemint

Global study: How does Covid-19 affect sense of smell and taste? – Mirage News

Over the last few weeks, more and more people infected with the coronavirus have been complaining that they cant smell or taste anything any more, suggesting that a loss of the sense of taste and smell may indicate an infection with Covid-19. The Global Consortium for Chemosensory Research (GCCR), a consortium made up of more than 400 researchers from all over the world, has now launched a broad-based online study aimed at recording whether Covid-19 patients experience a loss of taste and smell, as well as any changes to sensory perception within the mouth. Two researchers from FAU, Prof. Dr. Jessica Freiherr, professor for neuroscience of sensory perception, and Prof. Dr. Andrea Bttner, Chair of Aroma and Smell Research, are involved in the study.

Several publications have already been published on whether the loss of taste and smell is a symptom of Covid-19. Findings indicate that approximately 80 percent of patients reported a loss of their sense of taste and smell, says Jessica Freiherr. As yet, no widespread studies have been conducted on the topic. If valid figures were available on a global scale, however, the loss of the sense of taste and smell could officially be included in the list of symptoms caused by Covid-19. This would give medical institutions a basis for testing patients for Covid-19 even if they mainly report a loss of their sense of taste and smell rather than the other symptoms associated with the disease.

The study not only involves researchers focussing on aroma research but also neuroscientists, psychologists and ear, nose and throat specialists, and Jessica Freiherr hopes that it will provide detailed insights into a symptom which has been neglected until now: As a loss of the sense of smell is often experienced during a common cold, for example if you have a blocked up nose, researchers are keen to gain a deeper understanding of how the various aspects of the symptom interact, in particular how intensely it is experienced by patients, as well as how long it persists and how often it is experienced.

In order to ensure the results paint as representative a picture as possible, the organisers are still looking for a large number of participants from Germany who have either had a Covid-19 infection or a common cold (control group) in the last few weeks and are willing to spend approximately 10 minutes of their time completing an anonymous online survey. Anyone interested in taking part can contact the researchers below.

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Global study: How does Covid-19 affect sense of smell and taste? - Mirage News

Ipsen Reports Solid Sales Growth in First Quarter 2020 With Limited COVID-19 Impact – Benzinga

Regulatory News:

Ipsen ((Euronext: IPN, OTC:IPSEY), a global specialty-driven biopharmaceutical group, today announced its sales for the first quarter of 2020.

Aymeric Le Chatelier, Chief Executive Officer and Chief Financial Officer of Ipsen stated: "Thanks to the resilient Specialty Care product portfolio, the Group delivered solid sales growth in the first quarter with limited impact from COVID-19. Our priorities in these unprecedented times are to ensure the safety of our employees as well as driving business continuity so patients can maintain access to important medicines. Our 2020 guidance remains suspended until we have more visibility.

"During the first quarter, we received authorization to re-initiate dosing of palovarotene in patients with FOP and are now focused on working with the FDA and other agencies on defining a regulatory path forward with the objective of bringing palovarotene to FOP patients as quickly as possible.

"Thanks to the continued commitment and dedication of our people around the world, we are mobilized to face the COVID-19 pandemic. Together, we will continue to advance and strengthen our pipeline and drive growth and sustainability to fulfill our mission of improving patients' lives."

First quarter sales

First quarter 2020 unaudited IFRS consolidated sales

(in million euros)

Q1 2020

Q1 2019

%

Change

% Change

at constant currency1

Specialty Care

602.6

530.9

+13.5%

+12.5%

Consumer Healthcare

52.0

66.3

-21.5%

-21.9%

Group Sales

654.6

597.2

+9.6%

+8.7%

Continuing its growth trajectory, Ipsen achieved solid Group sales growth of 9.6% as reported, or 8.7%1 at constant exchange rates in the first quarter of 2020.

COVID-19 update

In the first quarter of 2020, the business remained strong with COVID-19 having a limited impact on sales due to increased stocking in the Oncology portfolio in some European countries toward the end of first quarter. This offsets a lower demand in China in February and March which had a significant impact on the Consumer Healthcare portfolio.

Ipsen continues to operate all of its manufacturing sites and is closely monitoring the situation. There is an adequate level of inventory with no supply chain issues anticipated to continue providing medicines to patients. There is also limited impact to date on clinical trials, with minimal disruption to investigational drug supply for ongoing patients, despite a general slowdown in the recruitment of new patients as well as new site activations in ongoing trials across Europe and the U.S.

Ipsen remains focused on ensuring that patients continue to have access to their treatments and on addressing the impact of this pandemic in their communities. Most Ipsen employees around the world, excluding mainly those at the manufacturing and distribution sites, are working from home today, and the commercial organization continues to support healthcare providers virtually.

In the second quarter of 2020, the situation in China should improve as business begins to resume. However, despite Ipsen's sustainable and resilient Oncology portfolio comprised mostly of highly-differentiated long-acting treatments for critical conditions, there is expected to be some impact from delayed diagnoses and lower new patient gains. It is also anticipated that there will be more of a negative impact on Dysport sales and revenues in both the therapeutics and aesthetics markets with delayed injections.

2020 Guidance

As announced on March 25th, the 2020 guidance remains suspended due to the lack of visibility on all the consequences of the global COVID-19 pandemic despite a resilient Oncology portfolio. It is not possible at this stage to quantify the impact on the Group's financial statements. Further updates will be provided as the situation evolves.

Palovarotene update

In the last few months, Ipsen made significant progress on advancing palovarotene, a top priority for the company. On 26 March 2020, clearance was received from the U.S. Food and Drug Administration (FDA) and other regulatory authorities to re-initiate palovarotene dosing in patients 14 years of age and older in the fibrodysplasia ossificans progressiva (FOP) clinical program. It was also decided to terminate the Phase 2 MO-Ped trial in patients with multiple osteochondromas (MO) in order to analyze the accumulated data and to better inform on the efficacy, safety and future of palovarotene in MO. A Complete Response was recently submitted to address the FDA's questions related to the partial clinical hold on patients under 14 years of age in palovarotene trials.

Positive topline results from pivotal Phase 3 CheckMate -9ER trial

CheckMate -9ER, a pivotal Phase 3 trial evaluating Cabometyx in combination with Opdivo (nivolumab) compared to sunitinib in previously untreated advanced or metastatic renal cell carcinoma (RCC), met its primary endpoint of progression-free survival (PFS) at final analysis, as well as the secondary endpoints of overall survival (OS) at a pre-specified interim analysis, and objective response rate (ORR).

The safety profiles of Cabometyx and Opdivo observed in the trial reflect the known safety profiles of the immunotherapy and tyrosine kinase inhibitor components in first-line RCC.

Detailed results of CheckMate -9ER will be submitted for presentation at an upcoming medical conference.

2020 Near-term priorities

Ipsen remains focused on the following near-term priorities:

2020 Annual Shareholders' Meeting and proposed distribution of 1.00 per share confirmed

The Annual Shareholders' Meeting will be held on 29 May 2020 behind closed doors, without the physical attendance of shareholders. It will be broadcast via a link provided on Ipsen's website. Ipsen will request its shareholders to cast their votes remotely and submit their questions in advance.

Furthermore, the company confirms the proposed distribution of 1.00 per share for the 2019 financial year to be paid on 5 June 2020. The ex-dividend date is set for 3 June 2020.

Conference call details

Ipsen will hold a conference call on Wednesday, 22 April 2020 at 2:30 p.m. (Paris time, GMT+1). Participants should dial in to the call approximately 15 minutes prior to its start. Participants can register for the call on the link below:

http://emea.directeventreg.com/registration/7159233

A recording will be available for seven days on Ipsen's website.

About Ipsen

Ipsen is a global specialty-driven biopharmaceutical group focused on innovation and Specialty Care. The Group develops and commercializes innovative medicines in three key therapeutic areas Oncology, Neuroscience and Rare Diseases. Its commitment to oncology is exemplified through its growing portfolio of key therapies for prostate cancer, neuroendocrine tumors, renal cell carcinoma and pancreatic cancer. Ipsen also has a well-established Consumer Healthcare business. With total sales over 2.5 billion in 2019, Ipsen sells more than 20 drugs in over 115 countries, with a direct commercial presence in more than 30 countries. Ipsen's R&D is focused on its innovative and differentiated technological platforms located in the heart of the leading biotechnological and life sciences hubs (Paris-Saclay, France; Oxford, UK; Cambridge, US). The Group has about 5,800 employees worldwide. Ipsen is listed in Paris (Euronext: IPN) and in the United States through a Sponsored Level I American Depositary Receipt program (OTC:IPSEY). For more information on Ipsen, visit http://www.ipsen.com.

Forward Looking Statement

The forward-looking statements, objectives and targets contained herein are based on the Group's management strategy, current views and assumptions. Such statements involve known and unknown risks and uncertainties that may cause actual results, performance or events to differ materially from those anticipated herein. All of the above risks could affect the Group's future ability to achieve its financial targets, which were set assuming reasonable macroeconomic conditions based on the information available today. Use of the words "believes", "anticipates" and "expects" and similar expressions are intended to identify forward-looking statements, including the Group's expectations regarding future events, including regulatory filings and determinations. Moreover, the targets described in this document were prepared without taking into account external growth assumptions and potential future acquisitions, which may alter these parameters. These objectives are based on data and assumptions regarded as reasonable by the Group. These targets depend on conditions or facts likely to happen in the future, and not exclusively on historical data. Actual results may depart significantly from these targets given the occurrence of certain risks and uncertainties, notably the fact that a promising product in early development phase or clinical trial may end up never being launched on the market or reaching its commercial targets, notably for regulatory or competition reasons. The Group must face or might face competition from generic products that might translate into a loss of market share. Furthermore, the Research and Development process involves several stages each of which involves the substantial risk that the Group may fail to achieve its objectives and be forced to abandon its efforts with regards to a product in which it has invested significant sums. Therefore, the Group cannot be certain that favorable results obtained during pre-clinical trials will be confirmed subsequently during clinical trials, or that the results of clinical trials will be sufficient to demonstrate the safe and effective nature of the product concerned. There can be no guarantees a product will receive the necessary regulatory approvals or that the product will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Other risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the Group's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the Group's patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions. The Group also depends on third parties to develop and market some of its products which could potentially generate substantial royalties; these partners could behave in such ways which could cause damage to the Group's activities and financial results. The Group cannot be certain that its partners will fulfil their obligations. It might be unable to obtain any benefit from those agreements. A default by any of the Group's partners could generate lower revenues than expected. Such situations could have a negative impact on the Group's business, financial position or performance. The Group expressly disclaims any obligation or undertaking to update or revise any forward-looking statements, targets or estimates contained in this press release to reflect any change in events, conditions, assumptions or circumstances on which any such statements are based, unless so required by applicable law. The Group's business is subject to the risk factors outlined in its registration documents filed with the French Autorit des Marchs Financiers. The risks and uncertainties set out are not exhaustive and the reader is advised to refer to the Group's 2019 Universal Registration Document available on its website (www.ipsen.com).

Comparison of Consolidated Sales for the First Quarter 2020 and 2019:

Sales by therapeutic area and by product

1st Quarter

(in million euros)

2020

2019

% Variation

% Variation at

constant currency1

Oncology

492.6

420.7

17.1%

15.7%

Somatuline

285.5

235.5

21.2%

19.5%

Decapeptyl

96.6

88.7

8.9%

8.6%

Cabometyx

72.4

53.9

34.2%

34.3%

Onivyde

31.2

34.6

Originally posted here:
Ipsen Reports Solid Sales Growth in First Quarter 2020 With Limited COVID-19 Impact - Benzinga

The Idea of the Brain explores the evolution of neuroscience – Science News

The Idea of the BrainMatthew CobbBasic Books, $32

Neuroscientistslove a good metaphor. Through the years, plumbing, telegraph wires and computershave all been enlisted to help explain how the brain operates, neurobiologistand historian Matthew Cobb writes in The Idea of the Brain. And like anymetaphor, those approximations all fall short.

Cobb leads afascinating tour of how concepts of the brain have morphed over time. Hiswriting is clear, thoughtful and, when called for, funny. He describesexperiments by neurosurgeon Wilder Penfield, who zapped awake patients brainswith electricity to provoke reactions. Zapping certain places consistentlydredged up memories, which Cobb calls oneiric experiences. His footnote onthe term: Look it up. Its exactly theright word. I did, and it was.

Cobb runs though the history of certain concepts used to explain how the brain works, including electricity, evolution andneurons. Next comes a section on the present, which includes discussions ofmemory, circuits and consciousness. Cobb offers tastes of the latest research, anda heavy dose of realism. Memory studieshave made progress, but we are still far from understanding what ishappening when we remember, Cobb writes. Despite big efforts, we still onlydimly understand what is going on when we see.Our understanding of how antidepressants work? Virtually non-existent.

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This real talk isrefreshing, and Cobb uses it to great effect toargue that neuroscience is stymied. There have been many similarmoments in the past, when brain researchers became uncertain about how toproceed, he writes. Scientists have amassed an impressive stockpile of brain facts,but a true understanding of how the brain works eludes us.

Dont expect a computer metaphor to help. Like a computer, the brainsmain job is to process information. But some experts argue that because brains are biologicalthey evolved within the vagaries of a bodythey operate in ways that a machine doesnt (SN: 8/23/16).

Cobb reckonsthat, among other reasons, the mere existenceof such objections is a harbinger of the end of the computer metaphor.But that doesnt mean the comparison was awaste. Metaphors clarify thoughts, he writes, and scientists would do well toponder what might replace the concept.

He ends the book with a creative exercise inlooking ahead to what the future might hold. The possibilities include the creation of conscious machines, or even having toaccept that there is no brain theory to be found. Still, our currentignorance should not be viewed as a sign of defeat, Cobb writes, but as achallenge.

Buy The Idea of the Brain from Amazon.com.Science Newsis a participant in the Amazon Services LLC Associates Program. Please see ourFAQfor more details.

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The Idea of the Brain explores the evolution of neuroscience - Science News