Category Archives: Neuroscience

Biohaven Appoints Bob Hugin to its Board of Directors – P&T Community

NEW HAVEN, Conn., June 10, 2020 /PRNewswire/ -- Biohaven Pharmaceutical Holding Company Ltd. (NYSE: BHVN), today announced the appointment of pharmaceutical industry leader Robert J. Hugin to its Board of Directors, effective immediately. Mr. Hugin previously served as the Chairman and Chief Executive Officer of Celgene Corporation where he was instrumental in the strategic growth and global expansion of the company. Celgene was ultimately acquired by Bristol-Myers Squibb in 2019 for a total equity value of approximately $74 billion.

Declan Doogan, M.D., Chairman of Biohaven's Board of Directors, commented, "We are excited to welcome Bob to Biohaven's Board of Directors as we have evolved to a commercial organization and look to the future. Having access to Bob's astute business and financial acumen will help Biohaven achieve our goal of becoming the leading pharmaceutical company focused on neuroscience indications."

Mr. Hugin joined Celgene in 1999 as Chief Financial Officer and served in positions of increasing responsibility during his 19-year tenure with the company, including Executive Chairman, Chief Executive Officer, President and Chief Operating Officer. Until his retirement in 2018, he was the Chairman of the Board of Directors, serving as Executive Chairman from 2016 to 2018. Under his leadership, Celgene saw unprecedented results across all facets of the company and grew by over $30 billion in market capitalization. He is a noted health expert, who advocated for the importance of business development collaborations, innovations in science and improved patient access.

Mr. Hugin stated, "Neuroscience remains one of the most important areas for drug development given the high burden of disability from diseases like Alzheimer's disease, rare neurologic indications, neuropsychiatric disorders and migraine. Biohaven has achieved impressive progress in its portfolio development since becoming a public company and is now successfully commercializing NURTEC ODT, its first product, for migraine. I hope to help transform Biohaven from a development company to a high growth commercial organization with multiple future products addressing large unmet needs in the neuroscience area. I look forward to being part of Biohaven's future success and working closely with Vlad and the rest of the Board."

Vlad Coric, M.D., Chief Executive Officer of Biohaven commented, "Biohaven is honored to welcome Bob to our Board of Directors. His impressive industry experience with high growth companies, strategic insight and passion for improving the lives of patients will be an asset to Biohaven in this time of significant growth as we continue to successfully commercialize our first product and advance our late-stage development portfolio. We are indeed fortunate to have Bob's extraordinary business and financial expertise to help guide Biohaven in advancing novel therapies to patients suffering from disabling neuroscience conditions."

Mr. Hugin also serves as a Director of Chubb Limited, Member of the Board of Trustees of Princeton University and Chair of The Darden School Foundation, University of Virginia. Additionally, Mr. Hugin is currently Chair of the Board of the Garden State Initiative, a nonpartisan research and educational organization focused on economic issues in New Jersey. He is a longstanding Member of the Board of Trustees of Family Promise, a national non-profit network assisting homeless families, and Director of the Parker Institute for Cancer Immunotherapy. Mr. Hugin is past Chairman of the Boards of The Pharmaceutical Research and Manufacturers of America and the Healthcare Institute of NJ. Prior to joining Celgene, Mr. Hugin was a Managing Director with J.P. Morgan & Co. Inc.

Mr. Hugin received an AB degree from Princeton University in 1976 and an MBA from the University of Virginia in 1985. He also served as a United States Marine Corps infantry officer during the intervening period.

About BiohavenBiohavenis a biopharmaceutical company focused on the development and commercialization of innovative best-in-class therapies to improve the lives of patients with debilitating neurological and neuropsychiatric diseases. Biohaven's neuroinnovation portfolio includes FDA-approved NURTEC ODT (rimegepant) for the acute treatment of migraine and a broad pipeline of late-stage product candidates across three distinct mechanistic platforms: CGRP receptor antagonism for the acute and preventive treatment of migraine; glutamate modulation for obsessive-compulsive disorder, Alzheimer's disease, and spinocerebellar ataxia; and myeloperoxidase (MPO) inhibition for multiple system atrophy and amyotrophic lateral sclerosis. For more information, visit http://www.biohavenpharma.com.

Forward-looking StatementThis news release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The use of certain words, including "believe", "continue", "may", and "will" and similar expressions, are intended to identify forward-looking statements. These forward-looking statements involve substantial risks and uncertainties, including statements that are based on the current expectations and assumptions of Biohaven's management about NURTEC ODT as an acute treatment for patients with migraine. Forward-looking statements include those related to: Biohaven's ability to effectively commercialize NURTEC ODT, delays or problems in the supply or manufacture of NURTEC ODT, complying with applicable U.S.regulatory requirements, the expected timing, commencement and outcomes of Biohaven's planned and ongoing clinical trials, the timing of planned interactions and filings with the FDA, the timing and outcome of expected regulatory filings,the potential commercialization of Biohaven's product candidates, the potential for Biohaven's product candidates to be first in class or best in class therapies and the effectiveness and safety of Biohaven's product candidates. Various important factors could cause actual results or events to differ materially from those that may be expressed or implied by our forward-looking statements. Additional important factors to be considered in connection with forward-looking statements are described in the "Risk Factors" section of Biohaven's Annual Report on Form 10-K filed with the Securities and Exchange Commission on February 26, 2020 and Biohaven's Quarterly Report on Form 10-Q for the quarter ended March 31, 2020 2020 filed with the Securities and Exchange Commission on May 7, 2020. The forward-looking statements are made as of this date and Biohaven does not undertake any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

Biohaven Contact:Vlad Coric, M.D.Chief Executive OfficerVlad.Coric@biohavenpharma.com

Media Contact: Mike Beyer Sam Brown Inc. mikebeyer@sambrown.com 312-961-2502

NURTEC is a trademark of Biohaven Pharmaceutical Holding Company Ltd.

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Biohaven Appoints Bob Hugin to its Board of Directors - P&T Community

Want to stop the COVID-19 stress meltdown? Train your brain – Fairfield Citizen

(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.)

Laurel Mellin, University of California, San Francisco

(THE CONVERSATION) Lets face it: Were all under stress right now. The uncertainty and constant health threats surrounding the coronavirus pandemic have upended our lives.

We may need two vaccines: one to protect us from the coronavirus and another from the toxic effects of too much stress. Could we train our brains to prevent this stress from becoming lodged in our brains, so we can bounce back faster from stress and even collect a kernel of wisdom from the experience?

Perhaps. Neuroscience research points to the stress-reactive circuits in the emotional brain as a trigger of toxic stress. These circuits are made of neurons that can guide us to respond ineffectively to stress. Once triggered, they unleash a cascade of stress chemicals. Instead of the brain orchestrating a symphony of effective self-regulatory processes and moderation, we have a garage band of dysregulation and extremes, which can cause chronic stress and rising rates of emotional, behavioral, social and physical health problems.

As a health psychology professor, I work on emotional brain training to help people deactivate and rewire the circuits that cause this stress overload.

A new crisis in emotional health

Scientists have been exploring these issues for over a century. Some 100 years ago, the psychoanalyst Sigmund Freud speculated that pathways in the brain caused emotional and behavioral problems. Tom Insel, as director of the National Institutes for Mental Health from 2002 to 2015, called for revolutionizing psychiatry with neuroscience to focus on faulty circuits. The White House BRAIN initiative, launched in 2013, has been busily mapping the brains billions of neurons and their connections to improve understanding of and treatments for a number of disorders.

Then came COVID-19, and suddenly 70% of the U.S. population was identified as moderately to severely distressed in a nationally representative study in April. That was up from 22% just two years earlier.

With a crisis in emotional health upon us, people can benefit from learning to take charge of these stress-reactive circuits and switch off the toxic stress chemical cascade they activate.

Understanding the emotional brain

Most of us arent aware that the neural circuits in our emotional brain the limbic system and subconscious memory systems in whats sometimes referred to as the reptilian brain are the major controllers of our emotional responses in daily life.

When a stimulus arrives in the brain, it activates either stress-resilient circuits, the internal calmers and healers, or stress-reactive circuits, the rabble-rousers that spiral us down into toxic stress.

The brain activates the strongest circuit, which then controls our responses. If it triggers a reactive circuit, that unleashes strong emotions that are challenging to process, especially since stress compromises the functioning of the part of our brains responsible for higher-level thinking and planning. The brain struggles to untangle those stuck emotions, and we become stressed out.

It gets worse. The longer these stress-reactive wires are activated, the more likely they are to activate other stress-reactive wires. One circuit can trigger another and another, which can cause an emotional meltdown of anxiety, numbness, depression and hostility which can overwhelm us for hours or days.

These problematic stress-reactive circuits are encoded during adverse childhood experiences, and later experiences of stress overload. The social isolation from sheltering in place and financial and health uncertainty has strengthened these faulty wires, turning the pandemic crisis into a virtual incubator for making our brains even more reactive and setting us up for a crisis in emotional health.

How to retrain the stressed brain

The stress wires in the emotional brain change through experience-dependent neuroplasticity the brain learns to be resilient by being resilient. It takes becoming stressed, then using emotional techniques to discover and change the unreasonable expectations and unwanted drives stored in that circuit.

Heres one technique: First, briefly complain about whats bothering you. For example: I cant stop beating myself up for all the things I have done wrong. This activates the reactive wire that has encoded a faulty response and makes rewiring possible.

Then, rapidly express emotions. Start with a burst of anger, which decreases stress and keeps the stressed thinking brain from becoming stuck in ruminating, zoning out or overanalyzing. Notice that you can then stay present to your strong, stress-fueled negative emotions, which will then flow rapidly. You can talk yourself through them by finishing phrases like I feel sad that ; I feel afraid that ; or I feel guilty that

That simple emotional release can ease your stress, and the previously unconscious unreasonable expectation encoded in the circuit will appear in your conscious mind. With the wire unlocked, you can then change the expectation into a reasonable one. For example, change I get my safety from being hard on myself to I get my safety from being kind to myself. The unwanted drive that amplifies your stress fades.

In small but important steps to release stress day by day, you train your brain for resilience.

Stress resilience as a social responsibility

Research has shown that emotions transmitted during social dialogue can eventually become large-scale group emotions. We can spread stress to others, and much like secondhand smoke, secondhand stress is becoming a concern.

Ive been surprised in my clinical practice at how quickly individuals link stress with social responsibility. One technology company executive said, Switching off my stress is good for me, keeps me from triggering stress in my family, and its something I do for our country. We are a stressed nation, and I want to be part of the solution.

Stress resilience as a foundation for health

Even though stress overload is a root cause of many health problems, the current model of treating the symptoms of stress rather than rewiring the brains stress response is not sustainable.

At some point, health cares addiction to using medications and procedures to treat the health problems caused by stress will require detox. A new emphasis on training the emotional brain for resiliency may emerge.

If we could reboot our brains for the high-stress times in which we live, just about every aspect of life would improve. Resiliency could provide a needed internal health safety net.

[Insight, in your inbox each day. You can get it with The Conversations email newsletter.]

This article is republished from The Conversation under a Creative Commons license. Read the original article here: https://theconversation.com/want-to-stop-the-covid-19-stress-meltdown-train-your-brain-138785.

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Want to stop the COVID-19 stress meltdown? Train your brain - Fairfield Citizen

Neuroscience Market Size and Share to See Modest Growth Through 2026 – Surfacing Magazine

CMI published a business research report on Neuroscience Market: Global Industry Analysis, Size, Share, Growth, Trends, and Forecasts 20202026. Neuroscience Market with 150+ market data Tables, Pie Chat, Graphs & Figures spread through Pages and easy to understand detailed analysis. The information is gathered based on modern floats and requests identified with the administrations and items.

The global Neuroscience Market analysis further provides pioneering landscape of market along with market augmentation history and key development involved in the industry. The report also features comprehensive research study for high growth potential industries professional survey with market analysis. Neuroscience Market report helps the companies to understand the market trends and future market prospective,opportunities and articulate the critical business strategies.

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Neuroscience Market: Competitive Landscape

Leading players operating in the global Neuroscience Market include:Alpha Omega, Inc., GE Healthcare, Axion Biosystems, Inc., Siemens Healthineers, Blackrock Microsystems LLC, Femtonics Ltd., Intan Technologies, LaVision Biotec GmbH, Mediso Medical Imaging Systems, Neuralynx Inc., NeuroNexus Technologies, Inc., Newport Corporation, Plexon Inc., Noldus Information Technology, Scientifica Ltd., Sutter Instrument Corporation, Thomas Recording GmbH, and Trifoil Imaging Inc.

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Neuroscience Market Size and Share to See Modest Growth Through 2026 - Surfacing Magazine

ApoE4 Damages Protective Barrier of the Brain – Being Patient

Researchers are making headway in explaining why people who carry the ApoE4 gene, the largest genetic risk factor for Alzheimers, are more likely to suffer from damaged blood-brain barriers.

It was never clear to researchers whether the ApoE4 gene was responsible for the early malfunction of the blood-brain barrier, a protective barrier shielding the brain from toxins or pathogens, or whether it worked together with the proteins beta-amyloid and tau.

Now, scientists have found that the gene may stimulate certain proteins in an inflammatory pathway, driving the blood-brain barrier to break down, regardless of the levels beta-amyloid and tau present in the brain.

Scientists have also pinpointed how ApoE4 may trigger the accumulation of beta-amyloid proteins along blood vessels influencing a condition known as cerebral amyloid angiopathy.

Researchers have overlooked vascular dysfunctions, said Axel Montagne, Associate Professor of Research Physiology & Neuroscience at University of Southern California. But in recent years with the advancement of new imaging tools and discovery of other biomarkers researchers realize that vascular functions are tightly linked to Alzheimers.

Nearly half of dementia cases are triggered, in part, by vascular disease which reduces blood supply to neurons in the brain. And lowering your risk of heart disease and stroke can help prevent dementia. As the saying goes: Whats good for the heart is good for the brain.

The blood-brain barrier is crucial as its endothelial cells are wedged closely together, forming the inner linings of the blood vessels and allowing only certain molecules and gases to flow into brain tissue. Meanwhile, cells like pericytes and astrocytes wrap along the surface of the blood vessels, upholding integrity of the blood-brain barrier.

In one of the recent studies, published in Nature, scientists examined the blood-brain barriers of participants who were either cognitively normal or displayed early symptoms of Alzheimers. The participants, aged 45 and older, underwent a battery of blood and cerebrospinal fluid tests, brain scans and imaging for the harmful proteins.

After accounting for variables such as lifestyle, demographics, and the presence of beta-amyloid and tau, the researchers found that carriers of ApoE4 with cognitive impairment had greater damage in their blood-brain barriers than ApoE3 carriers with cognitive impairment.

In fact, even healthy participants who carried the ApoE4 gene had greater blood-brain barrier dysfunctions compared to healthy participants without ApoE4.

People who have ApoE4 genes that are expressed in pericytes will have a cascade of molecular events that will release two proteins cyclophilin A and MMP9 for matrix metalloproteinase-9, Montagne said, who is an author of the study.

Those two molecules will destroy the tight junctions between endothelial cells You will see a physical gap between endothelial cells that will [become] a breach for blood to leak inside the brain.

The teams findings bolster growing evidence that vascular dysfunctions are linked with Alzheimers. Higher blood pressure especially at an earlier age increases risk of dementia later on. More than 90 percent of people with Alzheimers have cerebral amyloid angiopathy.

While researchers have known that ApoE4 is the strongest risk factor for the condition, the cellular and molecular links were unclear.

In a study published Monday, researchers sought to answer the question by developing lab models of the human blood-brain barrier.

It turned out that the pericytes from the ApoE4 cells drastically increased their expression level of ApoE, said Li-Huei Tsai, Picower Professor of Neuroscience and Director of the Picower Institute For Learning and Memory at MIT.

The scientists then identified a pathway that elevated ApoE expression, triggering more beta-amyloid to accumulate.

The reason why knowing the pathway is important is because we already have FDA-approved small molecules that can inhibit this pathway, Tsai said.

One of the FDA-approved drugs that the team tested is currently used to prevent organs from shrinking after transplants. And Tsai pointed to an intriguing finding from past studies: There are known publications following those individuals who received organ transplant under medication with this drug, Tsai said. These people turned out to have a much reduced incident of developing dementia.

Meanwhile, the researchers found that the drug reduced the levels of ApoE proteins and the buildup of beta-amyloid after administering it in mice and blood-brain barrier models.

A better understanding of the relationship between ApoE4 and the breakdown of a persons blood-brain barrier is critical to scientists ability to identify and engineer ways to prevent, mitigate, and cure that damage. Clinical trials to heal the blood-brain barrier are already underway.

Montagne and his team are testing various medications to treat impaired barriers in animal studies. Researchers are also conducting a clinical trial on a drug for stroke patients to heal their blood-brain barriers. And a clinical trial of ultrasound treatment is underway to disrupt the blood-brain barrier in the regions of the brain affected by Alzheimers, such as the hippocampus.

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Biomedical researchers aren’t using women and men equally as test subjects – Salon

A new study reveals that women continue to beunderrepresented in most biomedical studies, seemingly due to concerns that the variations caused by female hormones will complicate their conclusions. Coming on the heels of a study performed one decade ago that shed light on the problem, it suggests that female biology continues to be inadequately understood within the broader body of scientific knowledge.

The study followed up on a 2010report put together byAnnaliese Beery (who hails from the Departments of Psychology, Biology and Neuroscience at Smith College) and Irving Zucker (who comes from the Departments of Psychology and Integrative Biology and the Helen Wills Neuroscience Institute at University of California in Berkeley). The report found that, between2009 and now, women and other non-human females were shortchanged in biomedical research "often on the assumption that results from males apply to females, or because of concern that hormonal cycles decrease the homogeneity of study populations and confound effects of experimental manipulations." They argued that this compromised understanding of female biology and pointed out that "when only one sex is studied, this should be indicated in article titles, and that funding agencies favor proposals that investigate both sexes and analyze data by sex."

Following up on that study ten years later, Beery and a team from Northwestern University discovered some progress but other areas of disappointment. The number of studies in biological fields to include females jumped from 28 percent to 49 percent over the past decade, but in eight of the nine disciplines included in their report, the proportion of studies that analyzed results based on sex did not improve. Even worse, most of those studied did not provide any explanation for only focusing on one sex or not including sex-based analyses, and the ones that did offer explanations frequently "relied on misconceptions surrounding the hormonal variability of females."

The authors concluded that, while they were encouraged byhow the number of sex-inclusive research studies has gone up in most biological fields over the past decade,"at the same time, close to one third of all research studies that utilized both male and female subjects failed to quantify their sample size by sex."

The authors called for academic publishers to insist that research either include a description of sex or a rationale for focusing on one sex or not including sex-based analyses. They also recommended that funders require grant proposals to include "appropriate sex-based reporting and analyses" and that universities "encourage the consideration of sex as a biological variable" through various institutional and instructional methods.

"There has been a long tradition of viewing men as standard and women as variations to 'the normal,'" Dr. Bandy X. Lee, a forensic psychiatrist at Yale University, told Salon."Obviously, this skews rather than 'uncomplicates'the view of human experience."

She added, "It is similar to the research done on mental disorders. Because most research has been conducted in high-income countries, 80% of the world population has 'atypical' presentations."

The research bias could also speak to broader problems with equal representation overall in STEM fields. According to theAmerican Association of University Women, women only comprise 28 percent of the work force inscience, technology, engineering and math (STEM). This includes comprising only 47.7 percent of biological scientists, 42.5 percent of chemists and materials scientists, 25.8 percent of computer and mathematical occupations and 15.7 percent of engineers and architects.

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Biomedical researchers aren't using women and men equally as test subjects - Salon

We have a lot to learn about teaching while schools are closed, 2 superintendents say – NJ.com

By Michael LaSusa and Mackey Pendergrast

Instead of enjoying graduations and field days, students and teachers in New Jersey are laboring behind computer screens to move through curricula designed for a different context. But taking an instructional program intended for brick-and-mortar classrooms and recasting it in a virtual environment need not be a hastily executed shot in the dark. On the contrary, a purposeful approach rooted in established research in neuroscience and developmental psychology can guide school districts through this unprecedented shift to virtual learning. We see opportunities for reimagining and improving teaching and learning, both inside and outside the physical classroom.

The first opportunity involves instructional delivery. It is tempting to think that the best approach to virtual learning is to imitate a typical school day, with teachers and students logging on to their electronic classrooms at the same time as if they were all together. We do not think so. Those who have spent their careers working in preK-12 classrooms know how much skill and intentionality it takes to shepherd 20+ students through their learning -- managing behaviors, gauging understanding, and involving pupils meaningfully in lessons. This is difficult under ideal circumstances. When teachers are working with a class of students from their homes and through their screens, it is impossible.

Brain research explains why. In order to learn, the brain must be able to focus on one stimulus at a time. Attention is a limited capacity resource; there is only so much bandwidth available to select and attend to information. One of the biggest obstacles to learning, therefore, is cognitive overload.

In an online classroom, cognitive overload is a given: students are looking at a small screen divided among images of their classmates, teacher, and whatever instructional visuals the teacher may present. They must input and process all of that stimuli while at the same time listening, taking notes, and reflecting on the lesson content or others commentary. Additionally, students must contend with a host of possible distractions in their immediate environment -- cell phones, barking dogs, runaway siblings -- over which the teacher has no control. The brain needs focused attention long enough for the information to enter into the working memory. Virtual learning should seek to avoid cognitive overload by reducing unnecessary stimuli that compete with that attention. Thats a vote against lengthy periods of whole-class synchronous virtual instruction.

So what is the best method? To address this question, we need to look no further than to our students. Ask any kid how they figure out how to do something, and they will likely give you the same answer: YouTube. Whether its learning how to make a Rainbow Loom bracelet, memorize Steph Currys best moves, or play the chords to Living Colours Cult of Personality, YouTube is the go-to resource. Similarly, Khan Academy did not become a household name by brokering live tutoring sessions for groups of 25 students. Rather, founder Salman Khan realized that providing students with digestible video segments of mathematics content enabled students to work at an individualized pace, hit the pause button when necessary, and replay key moments as often as needed.

Think of the brain as a hiking path in a forest. Every time you travel down that path it becomes firmer and easier to discern. Similarly, every time a student rewatches a video clip to understand something more completely, to find a missing step, or to think slowly or rehearse, the neural connections and pathways are firming up in the brain, something neuroscientists call encoding and retrieval. A brain that is focused and relaxed is a brain that is ready to learn.

Dont students need to connect directly with their teachers and classmates? Of course! If the front end of virtual learning should rely on video content produced by teachers or thoughtfully selected from existing online platforms, the back end should focus on small group and individualized instruction. To accomplish this, teachers should use video conferencing apps to follow up with small groups of students, take questions, and check for understanding. This is also the place where teachers can encourage students to move through the learning pit-- that crucial stage of cognitive struggle where learners build their capacity and the brain embeds learning more concretely for future retrieval.

The second opportunity is for schools to permanently break away from the tyranny of time. Our current schooling structures date to the 19th century and our concept of credits and attendance are centered on those structures, including the Carnegie Unit -- an attempt to quantify how much seat time a student needs to acquire the material of a course.

Based on the need for seat time, the high school day is too long. We are hearing directly from our students during this prolonged school closure that they are sleeping more and feeling healthier. It is perverse that it has taken a pandemic to provide our adolescent students with a basic life need: sleep. Any conceptualization of schooling that aligns with brain research must afford students sufficient time for both sleep and exercise, both are essential ingredients for deep learning. When this school closure ends, we should leverage what we have learned, reduce the length of the school day, and rethink the demands of time that we impose on our students.

A final opportunity in this national experiment is to seize a salient takeaway: that going to school is vital to children. We need students to gather and learn how to navigate social relationships. We need students to interface with positive adult role models. We need students to take part in extracurricular programs that impart critical life skills.

When school resumes, we will better appreciate what we have been missing, but we should build upon what we have learned. After Hurricane Sandy, we better fortified New Jersey. We raised homes along the shore. We installed generators at critical facilities. We revised building codes. We should now take the same approach with our public schools.

We should make our instructional design stronger, better aligned with how the brain actually learns, and more conducive to helping students become independent learners. This will be crucial to position us for the next school closure and also to enable us to better serve our students at all times. Lets use this experience to fortify New Jersey again, this time for our children.

Michael LaSusa is the superintendent of schools in Chatham and was the 2018 New Jersey Region One Superintendent of the Year.

Mackey Pendergrast is the superintendent of schools in Morristown and is the 2020 New Jersey Superintendent of the Year.

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The Star-Ledger/NJ.com encourages submissions of opinion. Bookmark NJ.com/Opinion. Follow us on Twitter @NJ_Opinion and on Facebook at NJ.com Opinion. Get the latest news updates right in your inbox. Subscribe to NJ.coms newsletters.

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We have a lot to learn about teaching while schools are closed, 2 superintendents say - NJ.com

Depression among 70-year-olds may be associated with gender expression – News-Medical.Net

Reviewed by Emily Henderson, B.Sc.Jun 10 2020

Over time, depression has decreased among older women. But it is still nearly twice as frequent as among older men. This difference between men and women appears to be connected with both biological sex and gender expression, as a University of Gothenburg thesis investigating the prevalence of depression in 70-year-olds shows.

As life expectancy rises, depression in the older population is an escalating public health problem. The thesis shows that the prevalence of depression among 70-year-olds decreased among women, but not among men, from the mid-1970s to the mid-2010s. Nevertheless, depression remains nearly twice as common among women compared to men.

The sex ratio in depression is a well-known phenomenon. Still, we don't know the whole explanation for why this occurs, especially within the older population."

Therese Rydberg Sterner, a new Ph.D. graduate at the Institute of Neuroscience and Physiology at the University of Gothenburg

Today, the causes of depression are known to comprise a mix of biological, psychological, and social factors. But how gender-related factors are linked specifically to the sex ratio in the prevalence of depression remains unknown.

Gender expression includes various aspects of femininity, masculinity and androgyny. In Rydberg Sterner's study, it was measured by asking the participants to rate their own gender-stereotyped traits on a scale of one to seven. The participants are not classified as being exclusively masculine or feminine; instead, both men and women have a combination of feminine and masculine features."The purpose is to nuance the sex ratio in depression and investigate whether people's gender expression has any effect on their depression rates, irrespective of their biological sex," Rydberg Sterner says.

The thesis shows that the prevalence of depression was higher among both men and women with a higher self-rated level of femininity. For masculinity and androgyny, the inverse was found that is, men and women with higher self-rated levels of masculinity or androgyny had a lower depression rate."Since our survey was cross-sectional, we can't say anything about the chicken or the egg for this association."

To find out more about the association, Rydberg Sterner is currently collecting data about depression and gender expression in the follow-up examination of this cohort of septuagenarians who have now reached 75 years of age.

"We will be able to examine what comes first; is it depression that affects how we express ourselves and what we're like, or does our gender expression influence the risk of having depressive symptoms, or the way we perceive and talk about our experienced symptoms?"

Based on previous research, one of the researchers' hypotheses is that femininity might be connected with a greater propensity to communicate how one feels, compared with masculinity, but also that certain gender-stereotyped characteristics as such (e.g. problem-solving ability, logical thinking, self-assurance or worry), might be either risk or protective factors when it comes to depression.

The qualitative part of the thesis, which is based on focus group interviews, shows that the 70-year-olds who had suffered from depression expressed a lack of trust towards healthcare providers in terms of knowledge about, and treatment of, depression. In healthcare, there is no time for existential discussions before, during or after treatment.

"The interviewees feel that they aren't seen and listened to by the care providers while they are seeking help and being treated for depression. They'd like more communication, and to get more information about their clinical picture, possible treatment options and side-effects, as well as information about what they themselves can do to avoid depression to recur."

Rydberg Sterner hopes that her results will be used to further problematize the sex ratio in depression, and for giving depression among older people greater space in the research community in order to find additional preventive methods.

"It's also important to point out that the prevalence of depression in the population can be influenced. Otherwise, we wouldn't have seen it changing over time," she says.

Her thesis is based on the latest investigation of 70-year-olds, carried out from 2014 to 2016, in the longstanding Gothenburg H70 Birth Cohort Studies, and also on the prevalence of depression found in these studies' earlier cohorts of 70-year-olds.

Read more:
Depression among 70-year-olds may be associated with gender expression - News-Medical.Net

Massive Growth in Neuroscience Market 2020 Focusing on Growth, Demand & Scope by 2026| GE Healthcare , Siemens Healthineers , Noldus Information…

Neuroscience Market research is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis.

Neuroscience Market is growing at a High CAGR during the forecast period 2020-2026. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

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Key Players Profiled in This Report:

GE Healthcare , Siemens Healthineers , Noldus Information Technology , Mightex Bioscience , Thomas RECORDING GmbH , Blackrock Microsystems , Tucker-Davis Technologies , Plexon , Phoenix Technology Group , NeuroNexus , Alpha Omega

The key questions answered in this report:

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Neuroscience market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Neuroscience markets trajectory between forecast periods.

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Table of Contents:

Global Neuroscience Market Research Report

Chapter 1 Neuroscience Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Neuroscience Market Forecast

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Massive Growth in Neuroscience Market 2020 Focusing on Growth, Demand & Scope by 2026| GE Healthcare , Siemens Healthineers , Noldus Information...

Neuroscience Market 2024 Expected to reach Highest CAGR including major key players GE Healthcare, Siemens Healthineers, Noldus Information…

Due to the pandemic, we have included a special section on the Impact of COVID 19 on the NeuroscienceMarket which would mention How the Covid-19 is Affecting the Industry, Market Trends and Potential Opportunities in the COVID-19 Landscape, Key Regions and Proposal for Neuroscience Market Players to battle Covid-19 Impact.

The NeuroscienceMarket report is one of the most comprehensive and important data about business strategies, qualitative and quantitative analysis of Global Market. It offers detailed research and analysis of key aspects of the Neuroscience market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the Neuroscience market.

Top Leading players covered in the Neuroscience market report: GE Healthcare, Siemens Healthineers, Noldus Information Technology, Mightex Bioscience, Thomas RECORDING GmbH, Blackrock Microsystems, Tucker-Davis Technologies, Plexon, Phoenix Technology Group, NeuroNexus, Alpha Omega and More

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The report offers clear guidelines for players to cement a position of strength in the global Neuroscience market. It prepares them to face future challenges and take advantage of lucrative opportunities by providing a broad analysis of market conditions. the global Neuroscience market will showcase a steadyCAGR in the forecast year 2020 to 2024.

Product Type SegmentationWhole Brain ImagingNeuro-MicroscopyElectrophysiology TechnologiesNeuro-Cellular ManipulationStereotaxic Surgeries

Industry SegmentationHospitalsDiagnostic LaboratoriesResearch InstitutesOther

Our Complimentary Sample Neuroscience market Report Accommodate a Brief Introduction of the research report, TOC, List of Tables and Figures, Competitive Landscape and Geographic Segmentation, Innovation and Future Developments Based on Research Methodology.

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Regions Covered in the Global Neuroscience Market: The Middle East and Africa (GCC Countries and Egypt) North America (the United States, Mexico, and Canada) South America (Brazil etc.) Europe (Turkey, Germany, Russia UK, Italy, France, etc.) Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

Years Considered to Estimate the Neuroscience Market Size:History Year: 2015-2019Base Year: 2019Estimated Year: 2020Forecast Year: 2020-2024

Highlights of the Report: Accurate market size and CAGR forecasts for the period 2019-2024 Identification and in-depth assessment of growth opportunities in key segments and regions Detailed company profiling of top players of the global Neuroscience market Exhaustive research on innovation and other trends of the global Neuroscience market Reliable industry value chain and supply chain analysis Comprehensive analysis of important growth drivers, restraints, challenges, and growth prospects

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Neuroscience Market 2024 Expected to reach Highest CAGR including major key players GE Healthcare, Siemens Healthineers, Noldus Information...

Neuroscience explains why youre having trouble concentrating during the pandemic – AlterNet

Batrice Pudelko, Universit TLUQ

Fear, anxiety, worry, lack of motivation and difficulty concentrating students cite all sorts of reasons for opposing distance learning. But are these excuses or real concerns? What does science say?

At the beginning of the pandemic, when universities and CEGEPs, Qubecs junior colleges, were putting in place scenarios to continue teaching at a distance, students expressed their opposition by noting that the context was not conducive to learning.

Teachers also felt that the students were simply not willing to continue learning in such conditions. A variety of negative emotions were reported in opinion columns, letters and surveys. A petition was even circulated calling for a suspension of the winter session, which Education Minister Jean-Franois Roberge refused.

Students are not the only ones who have difficulty concentrating on intellectual tasks. In a column published in La Presse, Chantal Guy says that like many of her colleagues, she cant devote herself to in-depth reading.

After a few pages, my mind wanders and just wants to go check out Dr. Arrudas damn curve, Guy wrote, referring to Horacio Arruda, the provinces public health director. In short: Its not the time thats lacking in reading, its the concentration, she said. People dont have the head for that.

Why do students feel they dont have the ability for studies? Recent advances in cognitive science provide insights into the links between negative emotions and cognition in tasks that require sustained intellectual investment.

The heart has its reasons which reason knows not. This sentence from 17th-century philosopher Blaise Pascal sums up well the way in which western science has long separated the emotions of the hot universe from those of the cold universe in human rationality.

Walter Cannons physiological research has provided a first explanation of how emotions, especially negative emotions, take over our minds. He showed that emotion is a physiological warning system in the body, activating several structures below the cerebral cortex.

One of these structures, the amygdala, is now proving to be particularly important. The amygdala is rapidly activated in the face of threatening stimuli and allows us to learn to be wary of them. Faced with what could be a snake hidden among the branches, an animal will awaken its senses, alert its muscles and react quickly, without having the luxury of analyzing whether the slender shape is a snake or a stick.

For example, the emotions aroused by the sight of a snake in the grass or an untrustworthy political figure can capture our attention in spite of ourselves.In humans, the amygdala activates quickly and automatically in response to social stimuli loaded with negative emotions. Neuroscience research shows that people are not only highly sensitive to the emotional charge of their perceptions but they are also unable to ignore it.

One might object that for many people, fortunately, COVID-19 does not pose the same kind of threat as a snake encountered in the undergrowth. Our social systems provide us with protections that are previously unimaginable and we are much better prepared to deal with crisis situations.

And, learning situations established by educational institutions whether in-person classes or online classes always require that students focus their attention and consciously control their thoughts. As teachers know from experience, a great challenge while leading any lesson is keeping the attention of all students by ensuring that they remain focused on the activity at hand.

The cognitive psychologist Daniel Kahneman, a Nobel Prize winner in 2002, was among the first to propose that attention is a limited cognitive resource and that some cognitive processes require more attention than others. This is particularly the case for activities involving the conscious control of cognitive processes (such as reading or writing academic papers), involving what Kahneman calls System 2 thinking. That requires attention and mental energy.

In working memory, attention acts as a supervisor of cognitive resource allocation and a controller of action execution. The brain circuits associated with working memory and executive functions are those of the prefrontal cortex.Limited attention capacity is also at the heart of the theories proposing that conscious and controlled cognitive processes are carried out in working memory, which is compared to a mental space capable of processing a limited amount of new information.

Researchers have long believed that the processing of emotions through the amygdala does not depend on the attention resources of working memory. However, evidence is accumulating in favour of the opposite hypothesis, indicating that the circuits connecting the amygdala and the prefrontal cortex play an important role in discriminating between relevant and irrelevant information for the current activity.

For example, emotional stimuli were found to interfere with the performance of a working memory task especially since they were not very relevant to the task. Furthermore, as the cognitive load associated with the task increased (for example, when the task required more cognitive resources), the interference of emotional stimuli not relevant to the task also increased. Thus, it would appear that the more a task requires cognitive effort and concentration, the more easily we are distracted.

Much of the extensive research on anxiety by psychologist Michael Eysenck and colleagues supports this view. They show that people who are anxious prefer to focus their attention on stimuli associated with the threat, unrelated to the task at hand. These stimuli may be internal (worrisome thoughts) or external (images perceived as threatening).

This is also the case with worry as the repeated experience of seemingly uncontrollable thoughts about possible negative events. Both anxiety and worry eat up the attention and cognitive resources of working memory, resulting in decreased cognitive performance, especially for complex tasks.

Other research indicates that feelings of mental fatigue increase when performing a task while trying not to respond to outside demands. It has been suggested that mental fatigue is a particular emotion that tells us that our mental resources are being depleted.

Overall, this research suggests that we are depleting our attention resources to avoid paying attention to irrelevant, but emotionally charged information! It is now better understood why it is so difficult and exhausting to avoid checking ones email while reading a scientific text, to switch from email to Facebook and from Facebook to COVID-19 news coverage, when we are concerned about the curve or death toll in seniors homes.

Research in cognitive sciences today confirms what we know intuitively: studying requires attention, time and availability of mind. This research shows that cognitive and emotional processes are so intertwined in the brain that, for some researchers, such as Antonio Damasio, no thought is possible without emotion.

Not surprisingly, then, in a context full of messages about the dangers of the pandemic, students find it difficult to focus sustainably on their studies and most seem to lack quality time for reading or writing.

Batrice Pudelko, Professeure en psychologie de lducation, Universit TLUQ

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Read more from the original source:
Neuroscience explains why youre having trouble concentrating during the pandemic - AlterNet