Category Archives: Neuroscience

Brain Machine Interfaces and Neuromodulation Market Breaking new Grounds and touch new Level in Upcoming Year by Advanced Bionics, Advanced Brain…

Brain Machine Interfaces and Neuromodulation Marketreport focused on the comprehensive analysis of current and future prospects of the Brain Machine Interfaces and Neuromodulation industry. This report is a consolidation of primary and secondary research, which provides market size, share, dynamics, and forecast for various segments and sub-segments considering the macro and micro environmental factors.

This report provides an in-depth analysis of past trends, future trends, demographics, technological advancements, and regulatory requirements for the Brain Machine Interfaces and Neuromodulation market has been done in order to calculate the growth rates for each segment and sub-segments.The report also provides the market impact and new opportunities created due to the COVID19 pandemic.

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Top Key Vendors of this Market are:

Advanced Bionics, Advanced Brain Monitoring, BIOS, Bitbrain, BrainCo, Cochlear Limited, Cognixion, Dreem, Emotiv, Flow Neuroscience, Halo Neuroscience, InteraXon, MED-EL, Neurable, Neuralink, NeuroPace, Neuros Medical, NeuroSky, Nextmind, Paradromics, Synchron, Thync, Versus.

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Brain Machine Interfaces and Neuromodulation market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Brain Machine Interfaces and Neuromodulation markets trajectory between forecast periods.

The report provides insights on the following pointers:

Market Penetration:Comprehensive information on the product portfolios of the top players in the Brain Machine Interfaces and Neuromodulation market.

Product Development/Innovation:Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

Market Development:Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies.

Market Diversification:Exhaustive information about new products, untapped geographies, recent developments, and investments in the Brain Machine Interfaces and Neuromodulation market.

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Table of Contents

Global Brain Machine Interfaces and Neuromodulation Market Research Report 2020 2026

Chapter 1 Brain Machine Interfaces and Neuromodulation Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Brain Machine Interfaces and Neuromodulation Market Forecast

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Brain Machine Interfaces and Neuromodulation Market Breaking new Grounds and touch new Level in Upcoming Year by Advanced Bionics, Advanced Brain...

Researchers develop artificial liquid retinal prosthesis to counteract the effects of eye disorders – News-Medical.Net

Researchers at IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has led to the revolutionary development of an artificial liquid retinal prosthesis to counteract the effects of diseases such as retinitis pigmentosa and age-related macular degeneration that cause the progressive degeneration of photoreceptors of the retina, resulting in blindness.

The study has been published in Nature Nanotechnology:

The multidisciplinary team is composed by researchers from the IIT's Center for Synaptic Neuroscience and Technology in Genoa coordinated by Fabio Benfenati and a team from the IIT's Center for Nano Science and Technology in Milan coordinated by Guglielmo Lanzani.

It also involves the IRCCS Ospedale Sacrocuore Don Calabria in Negrar (Verona) with the team lead by Grazia Pertile, the IRCCS Ospedale Policlinico San Martino in Genoa and the CNR in Bologna. The research has been supported by Fondazione 13 Marzo Onlus, Fondazione Ra.Mo., Rare Partners srl and Fondazione Cariplo.

The study represents the state of the art in retinal prosthetics and is an evolution of the planar artificial retinal model developed by the same team in 2017 and based on organic semiconductor materials (Nature Materials 2017, 16: 681-689).

The "second generation" artificial retina is biomimetic, offers high spatial resolution and consists of an aqueous component in which photoactive polymeric nanoparticles (whose size is of 350 nanometres, thus about 1/100 of the diameter of a hair) are suspended, going to replace the damaged photoreceptors.

The experimental results show that the natural light stimulation of nanoparticles, in fact, causes the activation of retinal neurons spared from degeneration, thus mimicking the functioning of photoreceptors in healthy subjects.

Compared to other existing approaches, the new liquid nature of the prosthesis ensures fast and less traumatic surgery that consist of microinjections of nanoparticles directly under the retina, where they remain trapped and replace the degenerated photoreceptors; this method also ensures an increased effectiveness.

The data collected show also that the innovative experimental technique represents a valid alternative to the methods used to date to restore the photoreceptive capacity of retinal neurons while preserving their spatial resolution, laying a solid foundation for future clinical trials in humans.

Moreover, the development of these photosensitive nanomaterials opens the way to new future applications in neuroscience and medicine.

Our experimental results highlight the potential relevance of nanomaterials in the development of second-generation retinal prostheses to treat degenerative retinal blindness, and represents a major step forward."

Fabio Benfenati, Researcher, Istituto Italiano di Tecnologia

"The creation of a liquid artificial retinal implant has great potential to ensure a wide-field vision and high-resolution vision. Enclosing the photoactive polymers in particles that are smaller than the photoreceptors, increases the active surface of interaction with the retinal neurons, allows to easily cover the entire retinal surface and to scale the photoactivation at the level of a single photoreceptor."

"In this research we have applied nanotechnology to medicine" concludes Guglielmo Lanzani. "In particular in our labs we have realized polymer nanoparticles that behave like tiny photovoltaic cells, based on carbon and hydrogen, fundamental components of the biochemistry of life.

Once injected into the retina, these nanoparticles form small aggregates the size of which is comparable to that of neurons, that effectively behave like photoreceptors."

"The surgical procedure for the subretinal injection of photoactive nanoparticles is minimally invasive and potentially replicable over time, unlike planar retinal prostheses" adds Grazia Pertile, Director at Operating Unit of Ophthalmology at IRCCS Ospedale Sacro Cuore Don Calabria.

"At the same time maintaining the advantages of polymeric prosthesis, which is naturally sensitive to the light entering the eye and does not require glasses, cameras or external energy sources."

The research study is based on preclinical models and further experimentations will be fundamental to make the technique a clinical treatment for diseases such as retinitis pigmentosa and age-related macular degeneration.

Source:

Journal reference:

Maya-Vatencourt, J. F., et al. (2020) Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy. Nature Nanotechnology. doi.org/10.1038/s41565-020-0696-3.

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Researchers develop artificial liquid retinal prosthesis to counteract the effects of eye disorders - News-Medical.Net

Is This Column a Coherent Perspective? – Fair Observer

In a previous article on Fair Observer, I describe an unusual new way of communicating the most important parts of scientific truth through potentially noisy, biased news media. The key innovation is to consider them together, all at once, as a kind of jigsaw-puzzle about scientific truth, or a jigsaw textbook.

My own lofty, earnest hope is that the 20 articles I have written for Fair Observer so far (most under the column dubbed Tech Turncoat Truths or TTT), when assembled in that fashion, should provide my fellow human creatures with obvious, intuitive principles protecting ourselves. Not protecting money or power.

In writing this column, I have hewn as close to the scientific ideals of non-bias, simplicity, clarity and coherence as I can. Thats easier than it seems because their unifying reference frame is neuromechanical trust the trust humans have in our senses and ourselves. I am co-author of perhaps the only peer-reviewed quantitative framework explaining how humans (and even machines) form trust, the 60-page Sensory Metrics of Neuromechanical Trust. An additional, equivalent set of principles can be found in the Warrants section of the paper, 9.5 Hypotheses on the Informational Structure of Life. Both sets of principles comprise one of very few grand unified theories claiming to explain life, nervous systems, communication and economics. Of those grand theories, it is probably the only one explained directly to the public by an original author, no middlemen. I would be delighted to hear of any others.

That theory, in turn, itself originated in the capstone of my neuroscience career a research paper describing the physical structure of an ideal brain. In physics, the word ideal means not best but idealization, like an ideal gas made of simple particles. The function of an ideal brain, by the way, is defined as its hardest computational task. In brains, that task turns out to be simulating accurate, moving 3-D images of body and world using vastly insufficient sensory data. For such a near-impossible computation, the only plausible brain hardware would involve a nanoscopic medium I call simulatrix, which would compute with wavefronts. Experiments have not discovered simulatrix, but neither have they looked for it.

In all this work, my equal partner has been narratologist Criscillia Benford, whose mathematical understanding of commercial media in general (and multiplot novels like Bleak House in particular) is as broad as the ideal brain project. Fortunately, our two frameworks agree. We separately pursued those for a decade, before collaborating for another decade without ideological agenda or institutional funding. Our two approaches overlap so well because her understanding of human symbolic communication, my understanding of the brain and our mutual understanding of neuromechanical trust can all be grounded, in common, in the mathematical information sciences.

Transparency, objectivity and coherence are hard to get right in any perspective. But if you do get them right, it becomes all the harder for others to tamper with your ideas after the fact. So in evaluating a potentially coherent perspective, clarity and transparency ought to be the first things a reader looks for, even before checking facts or consistency.

First, if a scientific perspective isnt clear and transparent, you cant even check if it makes sense, much less use it even if it is. So as a first step, read a few TTT articles, besides these this one and its twin. Do they make sense to you? If not, save yourself the trouble of reading further.

Second, do they at least look like they might be intellectually coherent, as if they really did draw on the same few simple source ideas? To do that test, ultimately youd have to read each article, list ideas in them and compare pairs of ideas across the articles.That takes way more time and thought, so save it for later.

As an easier first step, one can at least look at what disciplinary subjects each article covers. If the pool of source ideas is, in fact, small and deep, different disciplines should be equally represented and equally interconnected. I believe that is the case, so below Ive taken the first step to make it even easier.

These articles are all grounded in the laws of information flow, which connect scientific disciplines as diverse as neuroscience, computer science and economics. In the table below, each article is labeled by the quantitative scientific disciplines it invokes. Each article is inter-disciplinary but in different ways.

For each of the preceding 18 articles, I have checked the major quantitative disciples it involves. Inspection shows that every discipline is connected to every other one at least once. This does not mean the articles are true, or even internally self-consistent. It merely does show that TTTs subject matter is not biased toward any particular discipline, and it links disciplines roughly symmetrically. That means that if the ideas do prove self-consistent, they could at least be a candidate for a coherent perspective.

If they pass these first two steps with you, the next step for you is to decide how much you care about ideal scientific truth. The more you want to know about ideal science, the more you will want to behave and think like an ideal reader. But whether or not your reading is ideal, youre still a perfect human being, just as you are. The truth is simple and true, but you dont need to know it to live.

*[Big tech has done an excellent job telling us about itself. Thiscolumn, dubbed Tech Turncoat Truths, or TTT, goes beyond the hype, exploring how digital technology affects human minds and bodies. The picture isnt pretty, but we dont need pretty pictures. We need to see the truth of what were doing to ourselves.]

The views expressed in this article are the authors own and do not necessarily reflect Fair Observers editorial policy.

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Is This Column a Coherent Perspective? - Fair Observer

Neuroscience reveals the mental blindspots that can become deadly in a pandemic – AlterNet

As the vast majority of companies rush to reopen and people rush back to public life, theyre falling into the trap of getting back to normal. Theyre not realizing were heading into a period of waves of restrictions once again, due to many states reopening too soon.

Indeed, some of the states to open early onward have alreadyreimposed some restrictions. This shows that as I predictedin a newspaper editorialway back at the start of the pandemic on March 10, 2020, we will greatly underestimate the pandemic and need to prepare to face rolling waves of restrictions and shutdowns until a vaccine. To avoid the trap of normalcy, we need to understand the parallels between whats going on now, and what happened at the start of the pandemic.

Very many prominentbusinessandpoliticalleaders downplayed the pandemic in its early stages. As a result, most business owners and plenty of ordinary citizens initially perceived the pandemic as little worse than the common cold.

This initial impression anchored their opinions toward minimizing the threat posed by COVID-19. In neuroscience and behavioral economics research, we call such initial impressions an anchor. Our minds tend to fall into a dangerous judgment error called theanchoring bias or focalism, where we give too much credit to the initial piece of information we received on a topic and perceive the rest of the information through the filter of that initial impression.

Yes, first impressions really matter, too much for our own good! That means as new information became available about the danger of COVID-19, people stuck to their initial impressions. They feel very reluctant to change their minds based on new evidence. Nowhere is this more evidence than in guidance on wearing masks.

Initially, the CDC indicated that theres no need to wear masks to protect yourself or others from COVID-19. Over time, as research evidence accumulated on the benefits of wearing masks, the CDCchanged its guidelines, highlighting the importance of masking in public.

Thats how science works: changing evidence results in changing guidelines. But thats not how our brains work, at least for those without training in critical evaluation of evidence.

The result? Many disregarded the new guidance, especially if those they consider authority figures did not reinforce it. Due to a mental blindspot calledemotional contagion, we tend to adopt the perspectives of those we see as authority figures. With their guidance, we can overcome initial anchoring; without it, we will stick to our initial perspective.

Just as dangerous is another dangerous judgment error that cognitive neuroscientists call thenormalcy bias. This mental blindspot refers to the fact that our gut reactions drive us to feel that the future, at least in the short and medium term of the next couple of years, will function in roughly the same way as the past: normally.As a result, we tend to vastly underestimate both the possibility and impact of a disaster striking us. Moreover, we will rush to get back to normal even when we should be preparing for the aftershocks or continuation of the disaster.

The normalcy bias, anchoring bias, and emotional contagion are three of over one hundred mental blindspots that cognitive neuroscientists and behavioral economists like myself callcognitive biases. Fortunately,recent research by myself and other scholarshas shown us how we can effectively defeat such dangerous judgment errors.

First you need to understand and evaluate where you yourself and your organization have fallen into each of these biases, and evaluate the damage caused by doing so. Then, you need to consider realistically the long-term outcomes and plan for a realistic scenario that addresses the likelihood of major disruptions.

Prepare to deal with waves of restrictions and loosenings for the long haul, especially as its likely that the coronavirus will get worse in the Fall, as weather gets colder. Remember, even if you made some bad decisions in the past, you always have the opportunity to make better decisions going forward tosurvive and thrive through the pandemic.

then let us make a small request. AlterNets journalists work tirelessly to counter the traditional corporate media narrative. Were here seven days a week, 365 days a year. And were proud to say that weve been bringing you the real, unfiltered news for 20 yearslonger than any other progressive news site on the Internet.

Its through the generosity of our supporters that were able to share with you all the underreported news you need to know. Independent journalism is increasingly imperiled; ads alone cant pay our bills. AlterNet counts on readers like you to support our coverage. Did you enjoy content from David Cay Johnston, Common Dreams, Raw Story and Robert Reich? Opinion from Salon and Jim Hightower? Analysis by The Conversation? Then join the hundreds of readers who have supported AlterNet this year.

Every reader contribution, whatever the amount, makes a tremendous difference. Help ensure AlterNet remains independent long into the future. Support progressive journalism with a one-time contribution to AlterNet, or click here to become a subscriber. Thank you. Click here to donate by check.

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Neuroscience reveals the mental blindspots that can become deadly in a pandemic - AlterNet

Fall 2020: How to Achieve Continuity in Teaching and Learning – Bowdoin News

Broene is a professor of chemistry and chair of the Continuity in Teaching and Learning Group (CTLG), a collection of twenty-three faculty, students, and staff charged by President Clayton Rose with developing an online teaching and learning model that will approach the challenge from a fresh perspective while building on the lessons learned during the spring 2020 semester. The group spent the better part of ten weeks coming up with a comprehensive plan for Bowdoin College in the falla plan that guides faculty in creating an online learning environment that delivers the defining aspects of a Bowdoin education.

About half of the group was made up of faculty members, the rest being technology, education, and communications specialists from the Bowdoin staff, as well as several students. Extensive surveys were conducted to assess what worked and what didnt in the second half of the 2020 spring semester, when the COVID-19 pandemic forced the College to pivot quickly to remote teaching. In issuing its findings and recommendations, the group also drew on the latest pedagogical research regarding online instruction and interviews with external consultants in the field.

After consulting with experts in the fields of science, medicine, and public health, President Rose recently unveiled Bowdoins plan for the upcoming academic year. Its designed to ensure the health and safety of the College community amid the uncertainty of the ongoing pandemic, while providing an excellent Bowdoin education to all students.

According to the plan, all first-year students will be on campus for the fall semester, along with transfer students, student residential life staff, students who for personal reasons are unable to pursue an online education at home, and a small number of senior honors students who require access to physical spaces on campus for their projects and can do so under health and safety protocols. All classes will be taught online, with the exception of most first-year seminars. As for the spring 2021 semester, Rose says: Assuming we are able to make it through the fall successfully in protecting the health and safety of our community, it is my intention and expectation to have sophomores, juniors, and seniors back on campus in the springwith priority given to seniors.

In planning for the fall, Broene says the group gave a lot of thought to the kinds of classes faculty have to deliver online. We have discussion-based classes; we have lecture-based classes. And then, he adds, there are lab-based classes, as well as performance, arts, and language-based learning. We asked faculty who taught in all of these modes to talk about what went well, what didnt, and what ideas they had.

The group has developed recommendations for all types of courses, suggesting what can best make them Bowdoin courses. One of the biggest takeaways from the spring experience concerned content delivery and the need for clear separation of synchronous learning, which is live and collaborative, involving all the students, and asynchronous content, which is prerecorded and on-demand. In a normal face-to-face classroom, we can improvise, says Crystal Hall. Students can ask questions of faculty right in the moment. It's harder to do that in an online setting.

Hall is associate professor of digital humanities and director of the digital and computational studies program. The recommendation, she says, is to break up larger classes into small groups (around twelve or fewer) for the discussion portion of the lesson. The feedback we had said that smaller groups are more enjoyable: there's more contact, theres time for everyone to participate, for people to ask questions and to really get their hands on the material. While professors continue to teach the class, they will benefit from an expanded use of student teaching assistants (TAs) to help with larger classes, as TAs are employed to facilitate and organize these smaller discussion groups.

The lectures, meanwhile, are to be delivered asynchronously and distilled into digestible chunks of fifteen or twenty minutes each that can be easily downloaded and listened to on-demand. This actually has some advantages over a classroom situation, says Broene. In a classroom you're watching somebody lecture while writing something. You're listening and you're trying to think about it all at the same time. Whereas online, he explains, you can review the content until you understand it.

Professor of Neuroscience and Biology Manuel Daz-Ros chaired the subcommittee that studied the issue of laboratory-based learning and how that will work. In their search for creative solutions, he and his colleagues have recommended a number of initiatives. Daz-Ros cited one example from his own work: Were going to ship equipment to students so they can conduct experiments on their own. That equipment includes an outreach effort called Backyard Brains, designed to introduce students to neuroscience. Among the pieces of the kit coming their way are headbands made to amplify, measure, and record brain activity. Its quite exciting, he says. Students can perform experiments on themselves!

There are many portions of our lab work that we can do well in an online environment, says Broene. For example, he points out, students can do fieldwork, collect data and interpret it, learning on the way how to use new types of instrumentation.

Some lab work, though, cannot be done remotely, he continues. I cant, for example, send a bottle of ether to my organic chemistry students. That would be dangerous and probably illegal.

This is where flexibility is required. Flexibility is key, he stresses, and that might include the flexibility to postpone a lab-based course that has to be done on campus until the spring semesterwhen a more regular routine will have hopefully returnedand use the fall semester to pursue labs that lend themselves more to online learning.

Carrie Scanga, associate professor of art, chair of the department of art, and director of the visual arts division, worked on performance-based classestheater and dance, music, language, visual artsto figure out best practices for online learning. Performance-based classes in general, says Scanga, will be influenced by what is going on in the outside world and the highly unusual circumstances under which students are learning. We know from our spring experience that the most impactful courses for students are ones that address contemporary issues. These classes give students a chance to interact with their feelings about these times, she adds.

As the report states, performance-based courses have the opportunity to directly address how the arts function to heal, maintain community, or disrupt societal systems in this era. Examples cited include courses on film acting, Dance in the TikTok Era, and improvised musical communities (balcony singing) as ways of interacting with the wider world. All of these courses, says Scanga, are reliant on creating a space where students can feel comfortable, whether they are singing, dancing, acting, or practicing a foreign language.

As with all classes, there is a heavy reliance on technology to achieve these goals and a great deal of the CTLG report is dedicated to this issue.

A number of lessons were learned in the spring about what technology best suits an online learning model, says Senior Vice President and Chief Information Officer Michael Cato. We were reacting to an emergency so we encouraged faculty to work with the tools they knew, and they used a lot of approaches and platforms. Now, as we plan for the fall, he says, we will emphasize consistency.

Decreasing the cognitive load for students is key, says Cato, so that the way in which they are learning does not distract from the learning itself. The new experience will be centered around two or three learning platforms with everything going through Blackboard. Classes may employ technologies like Zoom and Microsoft Teams, but the gateway to them, the starting point, will be the familiar Blackboard platform, he explains, where all student assignments and material for the week will be posted.

Then theres the issue of connectivity and how to ensure that all students, off campus and on, will be technically able to have the same learning experience. In addition to shipping equipment like tablets and laptops to students who need them, the College is also partnering with institutions that might be local to off-campus students and able to provide them with wireless internet connections. Theres also the eduroam initiative, says Cato. Its a global partnership of higher education institutionsincluding Bowdointhat offers shared free access to high-speed wireless networks. If a student lives near a college or a university, they may be able to access the institutions WiFi network using eduroam.

There is, explains Kathyrn Byrnes, an inherent paradox in the new teaching model, and its a welcome one. Shes director of the Baldwin Center for Learning and Teaching. As a student, while youre doing more on your own and working independently, there are also many opportunities to build community through one-on-one connections with your professors and fellow students.

Associate Dean for Academic Affairs Elizabeth Pritchard says it was also really important to involve students in the process and to learn from them. One of the things students are really good at is creating community online, she says. Five students served on the CTLG and helped address a number of issues, including that of time zones. We decided to change the time-block format, says Caroline Poole 22, to accommodate students across all time zones. To solve this problem, courses are being offered at different times for different days of the week.

Gavin Shilling 21 worked on a subcommittee looking at lecture-based classes. Our balance was trying to create a structure that everyone could work within but also allow for some flexibility for the professors to improvise and be creative in the moment.

Peyton Tran 23 says shes really optimistic going into the next semester because I know that Bowdoin professors are going to still be high-quality professorsjust through a different medium.

The terms remote instruction and online instruction are often used interchangeably. The difference is that the first entails temporarily transitioning content designed for face-to-face instruction to the internet, whereas the second is the purposeful design and implementation of a course for delivery online. Thus, Bowdoins spring semester was an instance of remote instruction, whereas planning for the fall entails the development of online teaching and learning.Page 5, CTLG final report.

The CTLG report lays out a detailed timeline for faculty, to help them prepare all the components and materials they need for the upcoming semester. Putting together an online course requires a lot of support from academic technology staff, and after extensive discussions with several companies, Bowdoin has hired a firm of outside experts to complement the internal team, selected because of their deep understanding of online education and that they get what is special about a liberal arts education.

With classes due to start on September 2, 2020, work is underway in earnest to ensure students this fall will experience the full benefits of a Bowdoin education, even if it is one that will look different from anything thats gone before.

While we dont have all the answers yet, says Broene, I learned enough in this work to be sure of two things: that the Bowdoin faculty is fully committed to their students education and that they are determined to get this right.

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Fall 2020: How to Achieve Continuity in Teaching and Learning - Bowdoin News

Mason Slaine Donates $1.5 Million in support of Boca Regional’s Keeping the Promise Capital Campaign – Baptist Health South Florida

June 30th, 2020 Baptist Health South Florida

BOCA RATON, FL June 30, 2020 Boca Raton Regional Hospital has received a significant commitment from Mason Slaine, in the amount of $1.5 million, towards Keeping the PromiseThe Campaign for Boca Raton Regional Hospital. Mason joins other notable philanthropists throughout our community who have generously contributed seven and eight-figure gifts to the capital campaign that now boasts $163 million raised thus far. In recognition of Masons generosity, the new Patient Admissions Area in the new patient tower will be named in his honor.

Mr. Slaine has been an extraordinary advocate and very active in our plans since he became involved with Boca Regional a few short years ago, said Lincoln Mendez, CEO of Boca Raton Regional Hospital. We are delighted to have him as a member of our family, as a Foundation Board member and as a lead donor to our Keeping the Promise campaign.

Slaine has served on both the Executive and Audit Committees since he joined the Boca Raton Regional Hospital Foundation in 2016. His $1.5 million gift is his second major philanthropic effort for Boca Raton Regional Hospital: Mason made a similar generous gift to the Marcus Neuroscience Institute a few years ago. In exchange for that gift, the Courtyard adjacent to the Institute bears his name and welcomes staff and visitors to a convenient and enjoyable outdoor space for a break and some respite.

Our communitys healthcare is vital, and that has been particularly understated in the last few months as we all navigate through COVID-19, said Slaine. I have always believed that Boca Regional is uniquely qualified to provide the highest quality of care we all need. I have personally utilized medical services, as well as family members have been cared for at the Hospital, so the facility and the people hold a special place in my heart. I believe in Keeping the Promise and in the next generation of healthcare it will bring. I am proud to be part of it.

The $250 million Keeping the Promise campaign is the largest campaign in the hospitals history. It is supporting major campus redevelopment plans including at the centerpiece, a new patient tower featuring all new surgical suites, an inviting patient lobby and all private patient rooms exceeding the latest safety standards for patient care. The Marcus Neuroscience Institute staff and capital investments are underway targeting all neuroscience programs with an emphasis on neurovascular/stroke, central nervous system, tumor, spine and epilepsy/seizure disorders. In the current hospital building, all existing rooms will be converted to private in a comprehensive renovation of all patient units. A new 972-car parking garage opened recently and will be connected to the Marcus Neuroscience Institute and the new tower when construction is complete. These investments are the initial steps toward an even broader vision for the campus with greater access points and even more specialties including a new Medical Arts Pavilion with an outpatient surgery center, physician offices and an additional parking garage.

###

About Boca Raton Regional Hospital FoundationThe Boca Raton Regional Hospital Foundation, Inc. is a not-for-profit organization for Boca Raton Regional Hospital. Boca Raton Regional Hospital is an advanced, tertiary medical center (BRRH.com) with 400 beds, 2,800 employees and more than 800 primary and specialty physicians on staff. The Hospital is a recognized leader in Oncology, Cardiovascular Disease and Surgery, Minimally Invasive Surgery, Orthopedics, Womens Health, Emergency Medicine and the Neurosciences, all of which offer state-of-the-art diagnostic and imaging capabilities. The Hospital is a designated Comprehensive Stroke Center by the Florida Agency for Health Care Administration (AHCA). BRRH is recognized in U.S. News & World Reports 2019 2020 Best Hospitals listing as a Top Ranked Regional Hospital, for the fourth consecutive year, and the highest ranked hospital in Palm Beach County. Boca Raton Regional Hospital is a part of Baptist Health South Florida.

Media Contacts:

For Boca Raton Regional Hospital:Michael Mauckermmaucker@brrh.com561-955-4706

For Boca Raton Regional Hospital Foundation:Jennifer Rohloffjrohloff@brrh.com561-955-3329

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Mason Slaine Donates $1.5 Million in support of Boca Regional's Keeping the Promise Capital Campaign - Baptist Health South Florida

June: New research in Brain Pathology | News and features – University of Bristol

Bristol scientists have discovered a novel pathology that occurs in several human neurodegenerative diseases, including Huntingtons disease.

The article, published in Brain Pathology, describes how SAFB1 expression occurs in both spinocerebellar ataxias and Huntington's disease and may be a common marker of these conditions, which have a similar genetic background.

SAFB1 is an important protein controlling gene regulation in the brain and is similar in structure to other proteins associated with neurodegenerative diseases of age. The team, from the University of Bristols Translational Health Sciences, wanted to find out if this protein might be associated with certain neurodegenerative conditions.

The researchers analysed SAFB1 expression in the post-mortem brain tissue of spinocerebellar ataxias (SCAs), Huntingtons disease (HD), Multiple sclerosis (MS), Parkinsons disease patients and controls.

They found that SAFB becomes abnormally expressed in the nerve cells of brain regions associated with SCA and HD. Both of these conditions are associated with a specific pathology, called a polyglutamine expansion (an amino acid repeat), which only occurs in SCAs and HD. The same pathology was therefore not seen in control Parkinson's disease or multiple sclerosis.

These novel findings highlight a previously unknown mechanism causing disease which, importantly, suggests SAFB1 may be a diagnostic marker for polyglutamine expansion diseases, such as HD said lead author, James Uney, Professor of Molecular Neuroscience at the University of Bristol.

We were also able to demonstrate how SAFB1 binds the SCA1 gene with the disease causing polyglutamine expansion (which causes spinocerebellar ataxia 1). As well as identifying a possible diagnostic marker, these findings open up the possibility of developing new therapeutic treatments for these rare but devastating neurodegenerative diseases.

The next step is to establish whether inhibiting SAFB1 expression protects patients.

Professor Uney said there was scope in the future to broaden the study to include other diseases, such as Alzheimer's, disease.

Paper:

'Abnormal expression of the scaffold attachment factor 1 in spinocerebellar ataxias and Huntingtons chorea,'in Brain Pathology.

This workwas supported by the BBSRC and the Medical Research Council, UKRI.

The study was made possible by the Bristol Brain Bank and the MRC-funded London Neurodegenerative Diseases Brain Bank at KCL.

Translational Health Sciences at the University of Bristol

Supported by funders such as the NIHR, the Medical Research Council, and charities such as the Wellcome Trust and British Heart Foundation, our research delivers pioneering treatments for patients and groundbreaking discoveries in basic science, across fields including neuroscience and endocrinology, cardiovascular sciences, and a range of other key areas.

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June: New research in Brain Pathology | News and features - University of Bristol

Small RNA regulates tau-related disease | NIA – National Institute on Aging

Sex differences can affect Alzheimers and other neurological disease outcomes. According to an NIA-supported study published in Nature Neuroscience, a small genetic molecule, called a microRNA, regulates some immune cell gene expression and the density of neurotoxic brain tangles in a sex-specific manner.

In Alzheimers disease, the protein tau clumps to form clumps of tangled fibers in the brain. Microglia immune cells of the brain and spinal cord are implicated in the accumulation of tau tangles in the brain. MicroRNAs regulate many of the genes in microglia. Led by researchers at Weill Cornell Medicines Appel Alzheimers Disease Research Institute in New York, the study was aimed at learning whether microglial miRNAs in mouse models regulate microglial gene expression and tau tangle pathology in a sex-specific manner.

Using a specific mouse model representing tau-related neurodegenerative disease, the researchers examined whether male and female microglia respond differently to tau tangles. Although they found that the densities of tau tangles were similar in male and female mice, gene regulation was altered to a far greater extent in the male microglia. These study results suggest sex-specific microglial responses to similar levels of tau tangles.

Using a mouse model that had microglial miRNAs removed, the researchers found sex-dependent differences in both the density of tau tangles and microglial gene regulation. Specifically, in the absence of microglial miRNAs, male mice had a higher density of tau tangles than female mice. In addition, the male microglia had an increased expression of genes involved in inflammation and phagocytosis a major mechanism to remove cell debris as well as genes characteristic of disease-associated microglia (DAMs). The researchers proposed that these differences may be exacerbated by age and tau-related disease, because the DAM genes were not active in younger mice.

The study findings illuminate the role of microglial miRNAs as one of potential key contributors to sex-specific phenotypes observed in neurological diseases. Additional research is needed to further expand the understanding of microglial biology in the context of neurodegenerative diseases.

This research was funded in part by NIA grants 1R01AG054214-01A1, U54NS100717, R01AG051390 and F31AG058505.

These activities relate to NIAs AD+ADRD Research Implementation Milestone 2.D. Create programs in basic, translational and clinical research aimed at comprehensive understanding of the impact of sex differences on the trajectories of brain aging and disease, phenotypes of AD and ADRD risk and responsiveness to treatment.

Reference: Kodama L, et al. Microglial microRNAs mediate sex-specific responses to tau pathology. Nature Neuroscience. 2020;23(2):167-171. doi: 10.1038/s41593-019-0560-7.

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Small RNA regulates tau-related disease | NIA - National Institute on Aging

New Director of Research Computing – University of Arkansas Newswire

University of Arkansas

Donald DuRousseau joins IT Services

DonaldDuRousseaujoinedIT Servicesas director of research computing on June 29.

In this role,DuRousseauwill provide strategic leadership in the areas ofcyberinfrastructuretechnologies and academic research computing services for the university.

DuRousseaubrings 20 years of technology experience including leadership with Cyber Security Education Solutions and George Washington University. He holds an M.B.A. from George Washington University and a B.S. in Computational Neuroscience from the University of California, Berkeley.

"This is a key role for IT Services as we partner with academic leaders on our campus to enhance and support the university'sresearch and discovery goals," said SteveKrogull, interim chief information officer. "Donald's focused experience within academic research will help us meet the needs of our students, faculty and staff in new innovative ways.

Learn more about IT Services leadership.

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New Director of Research Computing - University of Arkansas Newswire

Nanotechnology applied to medicine: The first liquid retina prosthesis – Science Codex

Genoa (Italy), 29 June 2020 - Researchers at IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has led to the revolutionary development of an artificial liquid retinal prosthesis to counteract the effects of diseases such as retinitis pigmentosa and age-related macular degeneration that cause the progressive degeneration of photoreceptors of the retina, resulting in blindness. The study has been published in Nature Nanotechnology: http://www.nature.com/articles/s41565-020-0696-3

The multidisciplinary team is composed by researchers from the IIT's Center for Synaptic Neuroscience and Technology in Genoa coordinated by Fabio Benfenati and a team from the IIT's Center for Nano Science and Technology in Milan coordinated by Guglielmo Lanzani, and it also involves the IRCCS Ospedale Sacrocuore Don Calabria in Negrar (Verona) with the team lead by Grazia Pertile, the IRCCS Ospedale Policlinico San Martino in Genoa and the CNR in Bologna. The research has been supported by Fondazione 13 Marzo Onlus, Fondazione Ra.Mo., Rare Partners srl and Fondazione Cariplo.

The study represents the state of the art in retinal prosthetics and is an evolution of the planar artificial retinal model developed by the same team in 2017 and based on organic semiconductor materials (Nature Materials 2017, 16: 681-689).

The "second generation" artificial retina is biomimetic, offers high spatial resolution and consists of an aqueous component in which photoactive polymeric nanoparticles (whose size is of 350 nanometres, thus about 1/100 of the diameter of a hair) are suspended, going to replace the damaged photoreceptors.

The experimental results show that the natural light stimulation of nanoparticles, in fact, causes the activation of retinal neurons spared from degeneration, thus mimicking the functioning of photoreceptors in healthy subjects.

Compared to other existing approaches, the new liquid nature of the prosthesis ensures fast and less traumatic surgery that consist of microinjections of nanoparticles directly under the retina, where they remain trapped and replace the degenerated photoreceptors; this method also ensures an increased effectiveness.

The data collected show also that the innovative experimental technique represents a valid alternative to the methods used to date to restore the photoreceptive capacity of retinal neurons while preserving their spatial resolution, laying a solid foundation for future clinical trials in humans. Moreover, the development of these photosensitive nanomaterials opens the way to new future applications in neuroscience and medicine.

"Our experimental results highlight the potential relevance of nanomaterials in the development of second-generation retinal prostheses to treat degenerative retinal blindness, and represents a major step forward" Fabio Benfenati commented. "The creation of a liquid artificial retinal implant has great potential to ensure a wide-field vision and high-resolution vision. Enclosing the photoactive polymers in particles that are smaller than the photoreceptors, increases the active surface of interaction with the retinal neurons, allows to easily cover the entire retinal surface and to scale the photoactivation at the level of a single photoreceptor."

"In this research we have applied nanotechnology to medicine" concludes Guglielmo Lanzani. "In particular in our labs we have realized polymer nanoparticles that behave like tiny photovoltaic cells, based on carbon and hydrogen, fundamental components of the biochemistry of life. Once injected into the retina, these nanoparticles form small aggregates the size of which is comparable to that of neurons, that effectively behave like photoreceptors."

"The surgical procedure for the subretinal injection of photoactive nanoparticles is minimally invasive and potentially replicable over time, unlike planar retinal prostheses" adds Grazia Pertile, Director at Operating Unit of Ophthalmology at IRCCS Ospedale Sacro Cuore Don Calabria. "At the same time maintaining the advantages of polymeric prosthesis, which is naturally sensitive to the light entering the eye and does not require glasses, cameras or external energy sources."

The research study is based on preclinical models and further experimentations will be fundamental to make the technique a clinical treatment for diseases such as retinitis pigmentosa and age-related macular degeneration.

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Nanotechnology applied to medicine: The first liquid retina prosthesis - Science Codex