Category Archives: Neuroscience

Residents and fellows celebrate the new Cape Fear Valley Health center | News | Campbell University – Campbell University News

Campbell University affiliate hospital Cape Fear Valley Health hosted a groundbreaking ceremony on Jan. 14 to celebrate the beginning of construction on the Center for Medical Education & Research and Neuroscience Institute.

Resident physicians and fellows were in attendance including Campbell Osteopathic Medicine alumni who are continuing their medical training at Cape Fear who affirmed the impact this new facility and its resources will have on education and patient services.

It is really amazing to be part of this groundbreaking ceremony, saidDr. Gunjan Joshi, a member of Campbells DO Class of 2017 who recently returned to complete his fellowship in cardiology at Cape Fear Valley.The new facility will serve a lot of residents and medical students going forward for decades to come. The 500 seat auditorium for lectures as well as technology including a simulation center where we will be able to train will be tremendous assets. It is an exciting time Im very happy to be back as a cardiology fellow and to be part of this.

The residents and fellows affirmed the project shows current and future residents the universitys and the health systems shared dedication to the future of medical education. Additionally, the center will provide a much needed dedicated space where residents and fellows can gather and learn from each other as well as through formal training activities and lectures.

Currently, residents dont often have opportunities to interact. Having a space where all the residents and fellows can be together and bounce ideas off of each other is going to improve patient care and our skills. We will have easier access to each others knowledge as well as formal training, said Dr. Elizabeth Roe, internal medicine resident and Campbell University alumna (DO Class of 2018).

Dr. Beaulah Vaz, third-year emergency medicine resident, is most excited about having a state of the art simulation lab on site. As an emergency medicine resident, we dont have a whole lot of time because we see so many patients, so having the opportunity to train here is going to be ideal.

The GME team at Cape Fear Valley do a phenomenal job, said Dr. Robin King-Thiele, associate dean for postgraduate affairs. This new facility will compliment the great work they are already doing and make Cape Fear Valley Health a premier destination for medical education.

The other asset the new facility will house is the Neuroscience Institute. Dr. Charles Haworth, the medical director for neurosurgery, shared how this aspect of the project magnifies the shared mission of Campbell and Cape Fear Valley to improve access to care for Fayetteville and the surrounding communities. The residents also shared how the center is already making a significant impact on patients at Cape Fear Valley by eliminating the need to transfer as many as two to three patients per week for neurology services.

The emergency department transferred many patients with neurology needs to Duke and UNC before Drs. Haworth and Stamates joined the staff, shared Dr. Vaz. Having a bigger neuro team in-house will be better for continuity of care for patients.

We have an entire floor of neurology patients. We have used telehealth for neurology consults which is wonderful, but having them in-house is so much better for our training and the patients. Physicians like Dr. Stamates are already a huge asset, affirmed Dr. Roe.

Surgery resident Dr. Ryan Huttinger elaborated on how this one medical service touches every department especially in regional Level 3 trauma center.

We are a bustling trauma center with a huge need for neuroscience specifically for traumatic brain injury and stroke. Being able to care for those patients closer to home is better for the patients it eliminates theobstacle of travel for acute and follow-up care for the patient and their caregivers.

Cape Fear Valley Health was among the first health systems to express interest in affiliating with Campbells osteopathic medical school; this next phase of investment and development increases the shared capacity to meet rural North Carolinas health care needs.

Today, we have a good thing before us health care, comfort, the stamping out of disease that is what we celebrate today, said Dr. Don Maharty, regional associate dean for graduate medical education at Cape Fear Valley Health for Campbell University. The GME Department residents, faculty, staff we are so thankful to everyone who came together to realize this vision.

For more information on graduate medical education visithttps://medicine.campbell.edu/academics/graduate-medical-education/

For more information on residency and fellowship programs at Cape Fear Valley Health visithttps://www.capefearvalley.com/residency/index.html

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Residents and fellows celebrate the new Cape Fear Valley Health center | News | Campbell University - Campbell University News

Neuroscience Market Analysis With Key Players, Applications, Trends And Forecasts To 2027 NeighborWebSJ – NeighborWebSJ

This report on Neuroscience market, published by IndustryGrowthInsights, is an in-depth analysis that studies crucial aspects of the market, which will assist clients to make right decision about their business investment plans and strategies. The market report entails a detailed information regarding the key segments and sub-segmentations including the product types, applications, and regions by examining the emerging market size, performance, and scope of each segment of the Neuroscience.

Keeping 2020 as the base year, the report evaluates the extensive data available of the Neuroscience Market for the historical period, 2015-2020 and assess the market trend for the forecast period from 2020 to 2027. With an aim to supply a robust assessment of the market, the report offers vital insights on industry growth opportunities and development, drivers and restrains for the Neuroscience market with focusing on consumers behavior and industrial trend for the prior years as well as the base year.

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One key aspect of the report is that it provides an extensive study on the impact of COVID-19 pandemic on the global market and explains how it would affect the future business operations of the industry. In short, IndustryGrowthInsightss report provides an in-depth analysis of the overall market structure of Neuroscience and assesses the possible changes in the current as well as future competitive scenarios of the Neuroscience market. Reflecting the pandemic effects, the report also includes information regarding the changing market scenario, competition landscape of the companies, and the flow of the global supply and consumption.

Besides describing the market positions of various major key players for the Neuroscience market, the report makes a concrete assessment on the key strategies and plans formulated by them over the recent years. In addition to this, the report provides information about recent developments such as product launch, entering merger and acquisition, partnership and collaboration, and expansion of the production plants by some key players.

This report includes the estimation of market size for value (USD) and volume (K MT), with applying top-down and bottom-up approaches to estimate and validate the overall scope of the Neuroscience market. The report is prepared with a group of graphical representations, tables, and figures which displays a clear picture of the developments of the products and its market performance over the last few years. With this precise report, it can be easily understood the growth potential, revenue growth, product range, and pricing factors related to the Neuroscience market.

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The published report consists of a robust research methodology by relying on primary source including interviews of the company executives & representatives and accessing official documents, websites, and press release of the companies related to the Neuroscience market. It also includes comments and suggestions from the experts in the market especially the representatives from government and public organizations as well as international NGOs. The report prepared by IndustryGrowthInsights is known for its data accuracy and precise style, which relies on genuine information and data source. Moreover, customized report can be available as per the clients wishes or specific needs.

Key companies that are covered in this report:

GE HealthcareSiemens HealthineersNoldus Information TechnologyMightex BioscienceThomas RECORDING GmbHBlackrock MicrosystemsTucker-Davis TechnologiesPlexonPhoenix Technology GroupNeuroNexusAlpha OmegaNeuroscienc

*Note: Additional companies can be included on request

The report covers a detailed performance of some of the key players and analysis of major players in the industry, segments, application, and regions. Moreover, the report also considers the governments policies in different regions which illustrates the key opportunities as well as challenges of the market in each region.

By Application:

HospitalsDiagnostic LaboratoriesResearch InstitutesOtherNeuroscience is applied mostly in the hospital with a market share of 47%. It is followed by Research Institutes and Diagnostic Laboratories

By Type:

Whole Brain ImagingNeuro-MicroscopyElectrophysiology TechnologiesNeuro-Cellular ManipulationStereotaxic SurgeriesAnimal BehaviorOtherWhole Brain Imaging, Neuro-Microscopy, and Electrophysiology Technologies are the top three types of neuroscience, with a combined market share of 62%Neuroscienc

As per the report by IndustryGrowthInsights, the Neuroscience market is projected to reach a value of USDXX by the end of 2027 and grow at a CAGR of XX% through the forecast period (2020-2027). The report describes the current market trend of the Neuroscience in regions, covering North America, Latin America, Europe, Asia Pacific, and Middle East & Africa by focusing the market performance by the key countries in the respective regions. According to the need of the clients, this report can be customized and available in a separate report for the specific region.

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Neuroscience Market Analysis With Key Players, Applications, Trends And Forecasts To 2027 NeighborWebSJ - NeighborWebSJ

Fragments of Rage – The Bulwark

Were drowning in debates about banning violence-inciting speech and its authors from social media platforms, but what if thats only half the story? While were busy focusing on the production sideall that the QAnoners, meme-dispensers, and internet conspiracists are doing on the various platforms that host themwere not paying enough attention to the consumption side: How the human brain receives and processes information, and how the designs of the platforms maximize profit by taking advantage of how our brains work.

The neuroscientific knowledge that explains the effectiveness of social media platforms and other Internet tools occasionally becomes a matter of public debate, as when the documentary The Social Dilemma hit Netflix last year. But the subject remains under-discussed, especially outside of the academy, and especially when compared to how important it is to our social, moral and political lives.

For present purposes, lets take just one aspect of neuroscientific researchrelating to the division of our brains into left and right hemispheres, with distinctive characteristicsand discuss how it relates to our heated debates about social media and worrying trends in our political life. Well use as our guide The Master and His Emissary, a 2009 overview of how this area of neuroscientific research relates to social history, by Iain McGilchrist, a British psychiatrist and professor of literature. (Joking about the books denseness and richness, economist Russ Roberts of EconTalk fame said it was one he couldnt recommend and couldnt recommend highly enough.)

The popular conception of the left and right brains, McGilchrist explains, is wronga result of vulgarization of research conducted in the 1960s and 70s. It is not true that one side of the brain controls reason and vision, while the other side of the brain controls emotion and language. Our continually evolving understanding is much more nuanced and, frankly, mysterious.

The right hemisphere of the brain, McGilchrist says, is generally attuned to the environment around us, seeking new information and keeping a weather eye out for potential threats. It is, in McGilchrists term, the master. The left hemisphere is designed for narrow attention, to encode and manipulate knowledge gleaned by the right. McGilchrist calls it the emissary, a faithful servant figuring out how to do things while the right side is concerned about relationships between things. This division is broadly suggestive of two huge evolutionary imperatives: finding food while not becoming food for others. The right side of the brain looks at the landscape and searches for meaning while the left produces maps. Even in left-handed people (that is, right-brain dominant people), the instructions for using tools are encoded in the left brain.

The book (and the subsequent documentary film) make this distinction clear in a particularly vivid way. In an experiment using pigeons, scientists discovered that using only their right eye (controlled by the left hemisphere) the birds were able to identify highly disaggregated pictures of human beings. In other words, if you chop up a vacation photo into hundreds of tiny pieces and mix them up leaving no discernable pattern, the birds could still pick out which photos had humans in them and which did not. The left hemisphere of their brains saw the pieces that made up a human being (an eye, an arm, a leg) even in fragments. Using just the right hemisphere (left eye), the pigeons couldnt distinguish which fragment photos had humans in them and which did not; the right hemisphere could only see the human figure when it was fully assembled. The human brain is constructed similarly. Our left brain focuses on the pieces while our right looks for the whole.

McGilchrist applies his divided-brain approach to our modern, high-technology society and argues that in our ever-stronger preference for the left-brains narrow, fragmentary take on the world we risk losing our capacity for integrating knowledge and relating to other people as well as the natural world. Our right-brain capacities, which help us to see the big picture and appreciate whole and embodied thingsincluding other peopleis subject to atrophy even as our ability to manipulate the world grows relentlessly stronger.

Through the fragmenting lens of social media we are living, increasingly, in the left-brains world. By stripping information of context and then actively manipulating it, social media has the power to prey upon left-brain tendencies and preferences by transforming bits of information into world-historic conspiracies. This phenomenon pre-dated the Internet, of course. Oliver Stone used the technique to brilliant effect in his film JFK, running and re-running the Zapruder film showing the killing of President Kennedy (Back and to the left, back and to the left) to make it seem impossible that the fatal bullet shot from behind could have driven Kennedys torso backward. Stones distortion helped fulfill the requirement for a second gunman and provided support for a conspiracy Stone said involved the entire U.S. military and intelligence apparatus. In fact, experts have demonstrated conclusively how that movement was not just possible but required by the ballistic and other conditions in Dealey Plaza on November 22, 1963. Partial information can be manipulated in the left hemisphere to create conspiracies; a fuller context protects against them.

The rise of social media has infinitely multiplied the potential and reality of fake news. The public concerns about allegations of fraud in the 2020 presidential election are in large part a product of a disaggregated reality created, or at least exacerbated, by social media. Deceptively edited videos of election workers mishandling ballots, the red mirage of election night, the entirely insane idea that a deceased Hugo Chvez teamed up with Dominion Voting to elect Joe Biden (among many other conspiracy theories)all these could be understood as weapons targeted at over-dominant left hemispheres searching for patterns and explanations where there are none. As McGilchrist points out, while emotions are housed in both hemispheres, anger lateralizes to the left, tending to fuel the rage associated with the feelings of powerlessness and fear that conspiracy thinking engenders. Focus enough people on deceptive, fragmented information that makes them believe a vast interlocking conspiracy has overturned the democratic will and you get the events of January 6.

The forces driving left-brain analytical fragmentation are immense and embedded throughout our society and economy. One example is our obsessive focus on STEM skill development while we devalue and reduce investment in subjects like art, literature, and philosophya kind of tripling-down on left-hemisphere preferences. This is all happening despite pleas from employers for workers with better right-hemisphere social capacities. Through these policy choices, and the accelerating demands for narrow, technical understanding of the world, we are unwittingly leaving ourselves increasingly vulnerable to false digitized information and the growing social and political conflict it generates.

It is important, of course, not to rely too heavily on any one neuroscientific explanation for human actions and social phenomena. The brain is like a universe unto itself: immense and infinitely complex. Our understanding of how it works is constantly revised as new research emerges. In addition to the research on brain hemispheres that McGilchrist explores, there are many other aspects of neuroscience and psychology that are relevant to our understanding of how social media have remade our public discourse, including research on distraction and on the brains reward system.

And even the best neuroscientific explanations can only take us so far. Scientific epistemology and reductionist methods that focus exclusively on mechanics can rarely offer us moral guidance. In his inaugural address on Wednesday, President Biden noted how manipulated and even manufactured facts are part of the raging fire that is destroying our politics, and called on us instead to listen to one another. Hear one another. See one another. Show respect to one another. To understand why that matters and how to do it we must consult the humanitiespoetry, art, history, philosophyand religion, sources of the ought of life that are impermeable to scientific analysis.

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Fragments of Rage - The Bulwark

Majorly indecisive? Welcome to Program II – The Chronicle – Duke Chronicle

Some students come to Duke knowing their major from their first day of classes. Others take years to figure out their path.

And others find that Dukes existing majors dont quite meet their passions, ending up in Program II, Dukes program that lets undergraduates design their own courses of study.

Senior Autumn Blamovilles Program II grew from two passions that seemed too distinct to combine: music and science.

After attending a performing arts high school in New York City before Duke, Blamoville wasnt ready to give up her love of music, but finding time for another major was proving a difficult task.

I knew a lot about music and its effects on the brain with neuroscience, but I had never explored other art forms and how they can work in collaboration with medicine and health care to yield positive health outcomes in older adults, Blamoville said.

While she originally planned to focus her studies on music, her Program II grew to include dance, theater and other forms of art and their intersection with healthcare.

In designing her Program II, Blamoville established a partnership with Sarah Wilber, assistant professor of the practice of dance, who introduced Blamoville to an entire world of working artists in the healthcare system.

Her interests led to her work with TimeSlips, a Milwaukee-based organization that uses creative storytelling to engage with persons living with dementia. Blamoville also worked with Dance for Parkinsons Disease to become a facilitator this past summer.

Blamoville is the vice president of the Program II Majors Union and is working to build community within Program II students despite the wide variety of interests.

Our common interest is that we are all so passionate about what we are doing even though it might not be the exact same thing, she said.

Because of the work required by each Program II student for approval of their topic, Blamoville has observed the deep investment of every student in their project. We are all very determined and want to look past what is in the normal constraints of a major, she said.

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One question stuck out among the rest and led junior Rishi Dasgupta to dedicate his academic career at Duke to answering it: What makes us who we are?

To tackle such a big question on the human experience, Dasgupta knew he had to go beyond just one area of study or a traditional major. His Program II curriculum approaches the topic of human consciousness from three angles: biological, philosophical and evolutionary.

If I wanted to ask these kinds of really big questions, I cant just look at one of these things, Dasgupta said.

It was during his sophomore year that Dasgupta designed a course schedule with classes that ranged from neuroscience to philosophy. Under the mentorship of Christine Drea, Earl D. McLean professor of evolutionary anthropology, Dasgupta was able to refine his question into a concrete path of study.

For Dasgupta, Program II allows him to pursue areas of study that he may never get the opportunity to experience after he graduates from Duke. While he hopes to eventually attend medical school and become a physician, Dasgupta wants to take advantage of every minute he has at Duke to pursue his passions.

He also sees his research on human consciousness as being particularly pertinent to one day become a medical provider.

When I think about neurosurgery, youre connecting with another person in the most visceral way possible, he said.

After a summer spent researching at a child abuse evaluation center, junior Carly Jones came back to Duke inspired to design a Program II that addressed the questions she didnt have time to answer in only a few weeks.

She designed a major that analyzes the psychosocial, neurological and genetic bases of childhood trauma and how that trauma is reproduced in communities through victim-offender overlap and increased participation in health risk behavior.

After that summer, I was left with the conclusion that maybe goodness and productivity in society isnt something that is indicative of personal characteristics but gained by privilege: whether you are born into an environment that is loving and nurturing or not, Jones said.

While she initially planned to major in African & African American studies or gender, sexuality and feminist studies, Jones has found an increased freedom through Program II to branch out into other departments like neuroscience and ethics. Jones is mentored by Patrice Douglass, assistant professor of gender, sexuality, and feminist studies, with whom she connected over their shared interests of the intergenerational mobility of harm and trauma.

Jones also took advantage of Dukes interinstitutional agreement with the University of North Carolina at Greensboro last semester. While she has no concrete plans for her senior project yet, Jones is looking forward to returning to a similar environment that began her Program II to apply the knowledge she has gained in the years since.

It took me almost the entire summer to realize the trauma didnt just start with the kids, it started generations before that, Jones said. It helped make me a more empathetic individual, and I want to carry that same empathy and understanding to my future work.

When senior Mac Gagne came to Duke, she knew she wanted to design her own Program II. But as she took classes throughout her first few semesters at Duke, she fell in love with math and declared it as her major her sophomore year.

While she loved the department and working with her professors, Gagne quickly realized her interests fell outside of the major curriculum.

Together, we came up with Program II as a way that I could study the exact area of applied mathematics I had been hoping to study all along: modeling human choice, she said.

With only one semester left at Duke, Gagne said shes excited to tackle her senior project, which focuses on mathematical modeling to improve the efficiency of triage practices in medicine.

By looking at a case study from Hurricane Katrina, Gagne is using math to see if more lives can be saved in emergencies while also taking into account moral and ethical implications, which she feels are too often left out of logic studies.

Understanding decisions, how they should be made, and how they will impact the world around you is like hacking into human potential, Gagne said. A good strategy is everything, and the decision really does make the human.

Without Program II, Gagne feels she could have never tackled her interdisciplinary project.

While her interests have led her to research and internships at places form the National Weather Service to the Duke Lemur Center, Gagne hopes to break down the stereotype that Program II students cant settle on one thing. According to Gagne, Program II students are both generalists and specialists who bridge together a variety of fields to specialize on one particular topic.

Program II students often have a very specific goal of what they want to scholastically contribute to the world around them but must move interdisciplinary mountains to get there, she said.

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Majorly indecisive? Welcome to Program II - The Chronicle - Duke Chronicle

Global Neuroscience Market 2020 Strong Development By Major Eminent Players, Research Analysis, Huge Growth and Forecasts to 2025 – Murphy’s Hockey…

Global Neuroscience Market 2020 by Company, Regions, Type and Application, Forecast to 2025 currently an appended report by MarketsandResearch.biz shows an expert and comprehensively analyzed recent business trends and upcoming market growth outlooks. The report will help you make informed decisions, know opportunities, plan new projects, explore drivers and restraints, plan effective business strategies, and provides an in-depth vision on the industry forecast for 2020 to 2025 time-period. The report demonstrates the global Neuroscience market size, market share, market trends, and development rate. The research study analyzes the progress of this market movement of significant players in this industry. Then it has covered major players including their detailed information such as name, company profile, and product information.

The report sheds light on major drivers and constraints, accounts of crucial market participants, splitting analysis, and prediction analysis. Comprehensive elements including global Neuroscience market share, supply chain, market trends, revenue graph, market size, and application spectrum are administrated in this study. Major players operating in the market are covered by encompassing their geographic reach, financial performance, strategic moves, product portfolio, and their strategic moves. Furthermore, the report evaluates the product pricing, production capacity, demand, logistics, supply, as well as the historical performance of the global market.

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NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.

All top players actively involved in this industry are as follows: GE Healthcare, Plexon, Mightex Bioscience, Siemens Healthineers, Tucker-Davis Technologies, Noldus Information Technology, NeuroNexus, Blackrock Microsystems, Thomas RECORDING GmbH, Phoenix Technology Group, Alpha Omega

The report highlights product types which are as follows: Whole Brain Imaging, Neuro-Microscopy, Electrophysiology Technologies, Neuro-Cellular Manipulation, Stereotaxic Surgeries, Animal Behavior, Other

The report highlights top applications which are as follows: Hospitals, Diagnostic Laboratories, Research Institutes, Other

Whats In The Offering:

The report provides in-depth knowledge about the various applications, types, and regions/countries. Furthermore, the key stakeholders will find the major trends, investments, drivers, vertical players initiatives, and insights of commercial products present in the market. The fastest & slowest growing market segments are pointed out in the study. New market players are accelerating their transition in the global Neuroscience market. Merger and acquisition activity is highlighted to explain the market landscape of this industry. Our report helps readers decipher the current and future constraints in the market.

Promising regions & countries mentioned in the global Neuroscience market report: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, etc.), Middle East & Africa (Saudi Arabia, Egypt, Nigeria and South Africa)

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Global Neuroscience Market 2020 Strong Development By Major Eminent Players, Research Analysis, Huge Growth and Forecasts to 2025 - Murphy's Hockey...

EdUHK Partners with NNU to Conduct Research on Neuroscience and Education Technology in Special Education – QS WOW News

The Integrated Centre for Wellbeing (I-WELL) of The Education University of Hong Kong (EdUHK), in collaboration with Nanjing Normal University of Special Education (NNU), and supported by the Tin Ka Ping Foundation (TKP), conducted research on neuroscience and education technology in special education.

The project was completed in 2020, and a presentation was conducted in November of the same year at the Heep Hong Society.

In the presentation, Professor Leung Chi-hung, Co-Director of I-WELL and Professor (Practice) at the Department of Special Education and Counselling of EdUHK, summarized three stages of professional training to benefit students with autism, hearing impairment or intellectual disabilities in the mainland, especially those living in remote areas.

NNU professors and in-service teachers who participated in the program shared their experience, along with their respective research topics, led by Professor Leung, Dr Liu Duo, Associate Head and Associate Professor at the Department of Special Education and Counselling of EdUHK, and Dr Angus Wang Li-chih, Assistant Professor, at the same department.

The topics covered the areas of music and information science, early childhood education, applied hearing impairment teaching, and sports and rehabilitation.

A special education e-manual, comprising concise knowledge about neuroscience and e-learning, was also developed. This knowledge can be transferred into applied research plans, addressing the learning needs of children with special educational needs in Nanjing. NGOs and special schools in Hong Kong will be invited to download the e-manual, together with the training manual, for reference.

I-WELL recently received another funding grant from TKP for a new engagement, titled Research, Development and Application of Educational Materials on Neuroscience and Education Technology in Special Education, which is a continuation of this project.

With NNU as the same partnering university, the new project will focus on the production of educational materials, training and applications related to neuroscience and education technology in special education to cultivate special education in the mainland.

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EdUHK Partners with NNU to Conduct Research on Neuroscience and Education Technology in Special Education - QS WOW News

New Evidence COVID-19 Invades the Brain – Medscape

Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center.

SARS-CoV-2 can invade the brain and directly act on brain cells, causing neuroinflammation, new animal research suggests.

Investigators injected spike 1 (S1), which is found on the tufts of the "red spikes" of the virus, into mice and found that it crossed the blood-brain barrier (BBB) and was taken up not only by brain regions and the brain space but also by other organs specifically, the lungs, spleen, liver, and kidneys.

"We found that the S1 protein, which is the protein COVID-19 uses to 'grab onto' cells, crosses the BBB and is a good model of what the virus does when it enters the brain," lead author William A. Banks, MD, professor of medicine, the University of Washington School of Medicine, Seattle, Washington, told Medscape Medical News.

"When proteins such as the S1 protein become detached from the virus, they can enter the brain and cause mayhem, causing the brain to release cytokines, which, in turn, cause inflammation and subsequent neurotoxicity," said Banks, who is also associate chief of staff and a researcher at the Puget Sound Veterans Affairs Healthcare System.

The study was published online December 16 in Nature Neuroscience.

COVID-19 is associated with a variety of central nervous system symptoms, including the loss of taste and smell, headaches, confusion, stroke, and cerebral hemorrhage, the investigators note.

Banks explained that SARS-CoV-2 may enter the brain by crossing the BBB, acting directly on the brain centers responsible for other body functions. The respiratory symptoms of COVID-19 may therefore result partly from the invasion of the areas of the brain responsible for respiratory functions, not only from the virus' action at the site of the lungs.

The researchers set out to assess whether a particular viral protein S1, which is a subunit of the viral spike protein could cross the BBB or enter other organs when injected into mice.

They found that when intravenously injected S1 (I-S1) was cleared from the blood, tissues in multiple organs, including the lung, spleen, kidney, and liver, took it up.

Notably, uptake of I-S1 was higher in the liver, "suggesting that this protein is cleared from the blood predominantly by the liver," Banks said. In addition, uptake by the lungs is "important, because that's where many of the effects of the virus are," he added.

The researchers found that I-S1 in the brains of the mice was "mostly degraded" 30 minutes following injection. "This indicates that I-S1 enters the BBB intact but is eventually degraded in the brain," they write.

Moreover, by 30 minutes, more than half of the I-S1 proteins had crossed the capillary wall and had fully entered into the brain parenchymal and interstitial fluid spaces, as well as other regions.

The researchers then induced an inflammatory state in the mice through injection of lipopolysaccharide (LPS) and found that inflammation increased I-S1 uptake in both the brain and the lung (where uptake was increased by 101%).

"These results show that inflammation could increase S1 toxicity for lung tissue by increasing its uptake," the authors suggest. Moreover, inflammation also increased the entry of I-S1 into the brain, "likely due to BBB disruption."

In human beings, male sex and APOE4 genotype are risk factors for both contracting COVID-19 and having a poor outcome, the authors note. As a result, they examined I-S1 uptake in male and female mice that expressed human APOE3 or APOE4 (induced by a mouse ApoE promoter).

Multiple-comparison tests showed that among male mice that expressed human APOE3, the "fastest I-S1 uptake" was in the olfactory bulb, liver, and kidney. Female mice displayed increased APOE3 uptake in the spleen.

"This observation might relate to the increased susceptibility of men to more severe COVID-19 outcomes," coauthor Jacob Raber, PhD, professor, Departments of Behavioral Neuroscience, Neurology, and Radiation Medicine, Oregon Health and Science University, Portland, Oregon, said in a press release.

In addition to intravenous I-S1 injection, the researchers also investigated the effects of intranasal administration. They found that although it also entered the brain, it did so at levels roughly 10 times lower than those induced by intravenous administration.

Banks said his laboratory has studied the BBB in conditions such as Alzheimer's disease, obesity, diabetes, and HIV.

"Our experience with viruses is that they do an incredible number of things and have a frightening number of tricks," he said. In this case, "the virus is probably causing inflammation by releasing cytokines elsewhere in the body that get into the brain through the BBB."

Conversely, "the virus itself may enter the brain by crossing the BBB and directly cause brain cells to release their own cytokines," he added.

An additional finding of the study is that whatever the S1 protein does in the brain is a model for what the entire virus itself does, because these proteins often bring the viruses along with them, he added.

Banks said the clinical implications of the findings are that antibodies from those who have already had COVID-19 could potentially be directed against S1. Similarly, he added, so can COVID-19 vaccines, which induce production of S1.

"When an antibody locks onto something, it prevents it from crossing the BBB," Banks noted.

Commenting on the study for Medscape Medical News, Howard E. Gendelman, MD, Margaret R. Larson Professor of Internal Medicine and Infectious Diseases and professor and chair of the Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, said the study is confirmatory.

"What this paper highlights, and we have known for a long time, is that COVID-19 is a systemic, not only a respiratory, disease involving many organs and tissues and can yield not only pulmonary problems but also a whole host of cardiac, brain, and kidney problems," he said.

"So the fact that these proteins are getting in [the brain] and are able to induce a reaction in the brain itself, and this is part of the complex progressive nature of COVID-19, is an important finding," added Gendelman, who is also the director of the Center for Neurodegenerative Disorders. He was not involved with the study.

The study was supported by the Veterans Affairs Puget Sound Healthcare System and by grants from the National Institutes of Health. The authors and Gendelman have disclosed no relevant financial relationships.

Nat Neurosci. Published online December 16, 2020. Full text

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New Evidence COVID-19 Invades the Brain - Medscape

Cormac the Llama Yields Antibodies That May Prove Effective Against COVID-19 – Department of Defense

Researchers at the Uniformed Services University of the Health Sciences recently identified pint-sized antibodies, or "nanobodies," that could protect against COVID-19. At least one of these nanobodies produced by a llama named Cormacalso appears to work well in either liquid or aerosol form, suggesting it could also help protect a person's lungs from infections.

The study was led by Dr. David Brody, director of USU's Center for Neuroscience and Regenerative Medicine, along with Thomas J. "T.J." Esparza, a Henry M. Jackson Foundation for the Advancement of Military Medicine employee working in support of CNRM. Both Esparza and Brody also work in the National Institutes of Health's National Institute of Neurological Disorders and Stroke .

Nanobodies are a type of antibody naturally produced by the immune systems of camelids, such as camels, alpacas and llamas. These proteins are about a tenth of the weight of most human antibodies on average. They can be isolated in the lab and essentially free-floating versions of the tips of the arms of heavy chain proteins, which form the backbone of a typical Y-shaped human immunoglobulin antibody found in the blood. These tips recognize proteins on viruses, bacteria and other invaders, also known as antigens. Therefore, they play a vital role in the immune system's defenses.

Nanobodies are also more stable, less expensive to produce and easier to engineer than typical antibodies. Therefore, they have been increasingly used for medical research. A few years ago, for example, scientists showed humanized nanobodies may be more effective at treating an autoimmune form of thrombotic thrombocytopenic purpura, a rare blood disorder, than current treatments.

Since the pandemic broke, several researchers have produced llama nanobodies against the SARS-CoV-2 spike protein, which is believed to be effective at preventing infections. In this study, published in Scientific Reports, the researchers used a slightly different strategy to find nanobodies that may work especially well.

"For years, TJ and I had been testing out how to use nanobodies to improve brain imaging. When the pandemic broke, we thought this was a once in a lifetime, all-hands-on-deck situation and joined the fight,"Brody, the senior author of the study, said. "We hope that these anti-COVID-19 nanobodies may be highly effective and versatile in combating the coronavirus pandemic."

The researchers found that at least one of these nanobodies, called NIH-CoVnb-112, may be highly effective at preventing infections or detecting virus particles by grabbing hold of SARS-CoV-2 spike proteins. These "spike proteins" act like a key by "opening the door to infections" when they bind to a protein found on the surface of certain cells, called the angiotensin converting enzyme 2 receptor, the researchers explained. They then found a way to isolate these nanobodies that block infections by covering the "teeth" of the spike protein, which bind to and unlock the ACE2 receptor. This was done by immunizing the llama, Cormac, five times over the course of 28 days with a purified version of the SARS-CoV-2 spike protein.

After testing hundreds of nanobodies, they found Cormac produced 13 nanobodies that could potentially be strong candidates, including one they refer to as NIH-CoVnB-112. The researchers then showed that the NIH-COVnB-112 nanobody could be effective at preventing infections.

To mimic the COVID-19 virus, the researchers genetically mutated a harmless 'pseudovirus' so that it could use the SARS-CoV-2 spike protein to infect cells that produce human ACE2 receptors. The researchers saw that relatively low levels of the NIH-CoVnb-112 nanobodies prevented the pseudovirus from infecting these cells in petri dishes.

Additionally, the researchers showed that the nanobody was just as effective in preventing the infections in petri dishes when it was sprayed through a nebulizer, or inhaler, often used to help treat patients with asthma.

"One of the exciting things about nanobodies is that, unlike most regular antibodies, they can be aerosolized and inhaled to coat the lungs and airways," Brody said. "This is promising in that it could potentially be used to protect the lungs from infections."

This study was supported by NIH Intramural Research Programs at the National Institute of Neurological Disorders and Stroke and National Institute of Environmental Health Sciences.

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Global Neuroscience Market Estimated To Record Double-Digit Growth Over 2020-2026 Zion Market Research – Farming Sector

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Global Neuroscience Market:Competitive Players

Alpha Omega, Axion Biosystems, Blackrock Microsystems LLC, Femtonics Ltd., Intan Technologies, LaVision Biotec GmbH, Mediso Medical Imaging Systems, Neuralynx Inc., NeuroNexus Technologies, Neurotar Ltd., Newport Corporation, Plexon Inc., Scientifica Ltd.

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Neuroscience Market Manufacturers Analysis And Industry Insights 2020-2026 | GE Healthcare, Siemens Healthineers, Noldus Information Technology,…

The Global Neuroscience Market research report delivers valuable insights into the existing and prospective trends observed in the industry, to give the readers a holistic view of market offerings, helping them recognize promising investment opportunities and other factors driving the revenue generation and overall profitability. The Neuroscience Market report offers an extensive investigation of all the relevant market features affecting its progress on both regional and global scales, while evaluating market drivers, restraints, hurdles, obstacles, and industry-centric trends. The report further deduces key trends observed in the historical data, along with upstream and downstream evaluation of major participants.

The Neuroscience market research focuses on the market structure along with various factors (positive and negative) that influence the market growth. The study contains a precise evaluation of the Neuroscience market, including growth rate, current market scenario, and volume inflation prospects, on the basis of DROT and Porters Five Forces analyses.

Major players covered in this report:

GE HealthcareSiemens HealthineersNoldus Information TechnologyMightex BioscienceThomas RECORDING GmbHBlackrock MicrosystemsTucker-Davis TechnologiesPlexonPhoenix Technology GroupNeuroNexusAlpha Omega

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Neuroscience market by Types:

Whole Brain Imaging, Neuro-Microscopy, Electrophysiology Technologies, Neuro-Cellular Manipulation, Stereotaxic Surgeries, Animal Behavior, Others

Neuroscience market by Applications:

Hospitals, Diagnostic Laboratories, Research Institutes, Others

Key questions answered in this research study What is the global (North America, South America, Europe, Africa, Middle East, Asia, China, Japan) production, production value, consumption, consumption value, import and export of Neuroscience? Who are the global key manufacturers of Neuroscience industry? How are their operating situation (capacity, production, price, cost, gross and revenue)? What are the types and applications of Neuroscience? What is the market share of each type and application? What are the upstream raw materials and manufacturing equipment of Neuroscience? What is the manufacturing process of Neuroscience? Economic impact on Neuroscience industry and development trend of Neuroscience industry. What will the Neuroscience market size and the growth rate be in 2025? What are the key factors driving the global Neuroscience industry? What are the key market trends impacting the growth of the Neuroscience market? What are the Neuroscience market challenges to market growth? What are the Neuroscience market opportunities and threats faced by the vendors in the global Neuroscience market?

Major regions covered in the report:North America [U.S., Canada, Mexico]Europe [Germany, UK, France, Italy, Rest of Europe]Asia-Pacific [China, India, Japan, South Korea, Southeast Asia, Australia, Rest of Asia Pacific]South America [Brazil, Argentina, Rest of Latin America]Middle East & Africa [GCC, North Africa, South Africa, Rest of Middle East and Africa]

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Detailed TOC of Global Neuroscience market:1 Market Overview1.1Neuroscience market Introduction1.2 Market Analysis by Type1.2.1 Type 11.2.2 Type 21.3 Market Analysis by Application1.3.1 Application 11.3.2 Application 21.4 Market Analysis by Region1.4.1 United States Market States and Outlook (2014-2026F)1.4.2 Europe Market States and Outlook (2014-2026F)1.4.3 China Market States and Outlook (2014-2026F)1.4.4 Japan Market States and Outlook (2014-2026F)1.4.5 Southeast Asia Market States and Outlook (2014-2026F)1.5 Market Dynamics and Development1.5.1 Merger, Acquisition and New Investment1.5.2 Market SWOT Analysis1.5.3 Drivers1.5.4 Limitations1.5.5 Opportunities and Development Trends1.6 Global Market Size Analysis from 2014 to 20261.6.1 Global Market Size Analysis from 2014 to 2026 by Consumption Volume1.6.2 Global Market Size Analysis from 2014 to 2026 by Value1.6.3 Global Price Trends Analysis from 2014 to 20262 Global Neuroscience market Competition by Types, Applications, and Top Regions and Countries2.1 Global Neuroscience market(Volume and Value) by Type2.1.1 Global Neuroscience market Consumption and Market Share by Type (2014-2020)2.1.2 Global Neuroscience market Revenue and Market Share by Type (2014-2020)2.2 Global Neuroscience market(Volume and Value) by Application2.2.1 Global Neuroscience market Consumption and Market Share by Application (2014-2020)2.2.2 Global Neuroscience market Revenue and Market Share by Application (2014-2020)2.3 Global Neuroscience market(Volume and Value) by Region2.3.1 Global Neuroscience market Consumption and Market Share by Region (2014-2020)2.3.2 Global Neuroscience market Revenue and Market Share by Region (2014-2020)Continued.

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