Category Archives: Immunology

Immunology and Serology | Johns Hopkins Medicine

Immunoglobulins

These are proteins in the body that have antibody activity.Excessive amounts of these proteinsmay be caused by a variety of conditions including infection, autoimmune disorders, cancers, and chronic diseases. A lack of these proteins may be caused by many conditions including cancers, medicines, and chronic diseases

HLA (human leukocyte antigens) typing

Tested todetermine compatibility in organ, tissue, and bone marrowtransplantation. Also tested to determine paternity, and to diagnose HLA-related disorders such as certain autoimmune conditions.

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Immunology and Serology | Johns Hopkins Medicine

Molecular Immunology – Journal – Elsevier

Molecular Immunology publishes original articles, reviews and commentaries on all areas of immunology, with a particular focus on description of cellular, biochemical or genetic mechanisms underlying immunological phenomena. Studies on all model organisms, from invertebrates to humans, are suitable....

Molecular Immunology publishes original articles, reviews and commentaries on all areas of immunology, with a particular focus on description of cellular, biochemical or genetic mechanisms underlying immunological phenomena. Studies on all model organisms, from invertebrates to humans, are suitable. Examples include, but are not restricted to:

To be acceptable for publication, studies that describe correlations between disease and genetic polymorphisms would normally be required to include novel mechanistic findings underlying the associations.

Clinical studies correlating disease and measurements of a molecule or cell type would likewise not be suitable for publication without novel mechanistic insights.

Studies describing pharmacological agents are welcome if they provide significant novelty on the mechanisms of action.

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Molecular Immunology - Journal - Elsevier

Immunology Program | Children’s Hospital of Philadelphia

The Immunology Program at Children's Hospital of Philadelphia (CHOP) provides sensitive, patient-centered care to children and young adults with immune deficiencies. Our team works closely with your whole family to provide education about immune deficiencies, as well as comprehensive immunology therapies.

We also help connect you with other families facing similar medical challenges, so you can learn from others who understand your experiences.

The Immunology Program is part of CHOP's Division of Allergy and Immunology.

Primary immune deficiency disease can present in many ways including recurrent infections, unusual infections and autoimmune diseases. Our expert staff is world renowned in the diagnosis of these diseases. Our Clinical Immunology Laboratory provides advanced diagnostic tools, which are critical to finding an accurate diagnosis for your child and beginning a treatment plan that will improve her quality of life.

Particular areas of clinical emphasis include:

Each of the nearly 150 primary immune deficiency diseases has a specific therapy. We offer the most up-to-date therapies for our patients.

Our Transition Clinic supports young adults as they become more independent and their medical needs change. We emphasize management of immune deficiencies as a way of life rather than an illness that restricts opportunities.

The Immunology Service participates in longitudinal registries of patients with immune deficiencies that aim to define optimal treatments of these diseases. These studies include USIDNET, CIBMTR and PIDTC. Ongoing research efforts are focused on:

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Immunology Program | Children's Hospital of Philadelphia

Immunology | Boston Children’s Hospital

The Division of Immunology at Boston Childrens Hospital provides evaluation and treatment for patients with asthma, allergies, immune system disorders, skin diseases and rheumatologic and inflammatory conditions.Our approach to patient care

Our experienced allergists, immunologists, dermatologists, and rheumatologists are all appointed to the Harvard Medical School faculty. They treat more than 30,000 patients each year both on our inpatient services at Boston Childrens Hospital and in our outpatient clinics located at seven sites in the greater Boston area and beyond.

In addition to our specialized physicians, our programs include a range of experienced ancillary providers, such as psychologists and nutritionists, and we work closely with subspecialists in a number of other Boston Childrens Hospital programs to provide coordinated care for our patients. Several multidisciplinary clinics are offered including the FACETS food allergy clinic as well as specialized programs for severe asthma, atopic dermatitis, multiple autoimmune diseases and dermatology and autoimmunity.

Our clinical programs are widely recognized. We are a founding site of the International Consortium for Immunodeficiency, an international referral center for children with immune system disorders and have achieved national designations as a Food Allergy Research & Education (FARE) Center of Excellence, Federation of Clinical Immunology Societies (FOCIS) Center of Excellence for immunodeficiency and a Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry site for autoimmune disorders.

The Division is a major site of NIH-funded research and is widely recognized as the leading center for clinical and basic investigation in pediatric immunology, allergy and rheumatology. We host the most sought-after Harvard Medical School-affiliated fellowship training programs for young physicians specializing in Allergy & Immunology, Pediatric Rheumatology and Pediatric Dermatology.

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Immunology | Boston Children's Hospital

Immunology – 8th Edition

Preface vii

List of Contributors ix

SECTION 1

Components of the Immune System 1

1 Introduction to the Immune System 3

David Male

2 Cells, Tissues, and Organs of the

Immune System 17

Peter M Lydyard and Nino Porakishvili

3 Antibodies 51

Roy Jefferis

4 Complement 71

B Paul Morgan

5 T Cell Receptors and MHC Molecules 89

David B Roth

SECTION 2

Modes of Immune Response 107

6 Mechanisms of Innate Immunity 109

David Male

7 Mononuclear Phagocytes in Immune

Defense 125

Luisa Martinez-Pomares and

Siamon Gordon

8 Antigen Presentation 143

David Male

9 Cell Cooperation in the Antibody

Response 157

Joseph C Marini and Kalpit A Vora

10 Cell-mediated Cytotoxicity 171

Victoria Male

11 Regulation of the Immune Response 183

David Bending

12 Immune Responses in Tissues 199

David Male

SECTION 3

Defense Against Infectious Agents 209

13 Immunity to Viruses 211

Persephone Borrow and Anthony A Nash

14 Immunity to Bacteria and Fungi 223

Gregory J Bancroft

15 Immunity to Protozoa and Worms 243

Richard J Pleass

16 Primary Immunodeficiencies 263

Luigi D Notarangelo

17 AIDS, Secondary Immunodeficiency

and Immunosuppression 277

Dean H Kedes and Lisa A Nichols

18 Vaccination 289

Colin Casimir

SECTION 4

Immune Responses Against Tissues 305

19 Immunological Tolerance 307

Thomas Kamradt

20 Autoimmunity and Autoimmune

Disease 323

James E Peters and David A Isenberg

21 Transplantation and Rejection 341

Andrew J T George

22 Immunity to Cancers 355

Pramod K Srivastava

V

SECTION 5

Hypersensitivity 369

23 Immediate Hypersensitivity (Type I) 371

Thomas A E Platts-Mills

24 Hypersensitivity (Type II) 393

David Male

25 Hypersensitivity (Type III) 405

David P DCruz

26 Hypersensitivity (Type IV) 419

Warwick J Britton

Appendices online

1. Major Histocompatibility Complex

2. CD System

3. The Major Cytokines

4. Human Chemokines and Their Receptors

Critical thinking: Explanations 433

Glossary 445

Index 455

vi

Contents

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Immunology - 8th Edition

Immunology and Microbiology Concentration Graduate …

NOTE: This page is for detailed information about the Immunology & Microbiology Advanced Concentration only. All inquiries concerning admission to the BMS must be directed to the BMS Admissions office at biomed@med.ufl.edu. More information on admissions is also available on the Admissions Page.Overview

The Advanced Concentration in Immunology and Microbiology is one of eight advanced concentrations leading to the Ph.D. degree under the auspices of the Graduate Program (BMS) in Biomedical Sciences at the University of Florida College of Medicine.

The Immunology and Microbiology program offers graduate training in cellular and molecular immunology including immunopathology, immunogenetics, and autoimmunity and in microbiology, including virology, bacteriology, microbial genetics, and microbial pathogenesis.

The program is designed for maximum flexibility in the educational experience of the individual student and provides broad opportunities for training in immunology and microbiology, emphasizing both the cellular and molecular aspects. Following admission, students complete a year of common interdisciplinary core curriculum of classroom studies. In addition, the students participate in seminars, journal clubs, and research rotations. At the end of the first year students choose a research advisor from approximately 200 faculty members belonging to the basic science departments of the College of Medicine and the College of Dentistry.

The faculty members of the Immunology & Microbiology advanced concentration occupy research space in the College of Medicine, College of Dentistry, and Veterans Administration Medical Center in Gainesville.

Learn about David Bloom, Ph.D.s work on novel therapy development for Herpes Simplex Virus (HSV).

Dr. Bloom has one of the College of Medicines training grants for Basic Microbiology and Infectious Disease (T32AI007110-32).

Students interested in pursuing bacteriology, virology or immunology research as a student in the Immunology & Microbiology advanced program are strongly encouraged to register in the spring semester of their first year for two, semester-long courses: Infectious Diseases (GMS 6121 3 credits) and Principles of Immunology (GMS 6140 4 credits). A major impetus for students to participate in both courses simultaneously is the significant integration between the classes that will be included in the twice weekly discussion sessions. It is our goal that these courses will provide the foundation for each aspect of our advanced curriculum. We expect students in the advanced courses of all MSI three tracks (Bacteriology, Immunology, and Virology) to have the knowledge obtained from these two courses.

First-year students with very strong backgrounds in immunology and/or microbiology may begin taking advanced courses after discussing their educational background and goals with an Advanced Concentration Co-Coordinator the Associate Dean for Graduate Education. Instructors consent must be obtained before registering for courses.

Suggested Courses for Advanced Students: Most Immunology & Microbiology students are expected to take about four of the six minimum required credits of advanced coursework within the Immunology & Microbiology concentration offerings, but the final selection is determined by the student and approved by the students supervisory committee. Advanced graduate courses are organized by the Immunology & Microbiology advanced concentration and may be taken to fulfill the minimum advanced course requirement of at least 6 credits beyond the first year are listed at the following two web pages:

Fall Semester Advanced Courses | Spring Semester Advanced Courses

GMS 6038, Bacterial Genetics & Physiology (1 credit) is offered in the Fall. GMS 6121, Infectious Diseases (3 credits), a comprehensive introduction to bacteriology and bacterial pathogenesis including a week each of virology and mycology, is offered in the Spring and Fall.

The Pathobiology Department at the College of Veterinary Medicine offers a three pack of advanced modules focused on the molecular pathogenesis of specific parasitic or bacterial diseases (see VME 6464 & VME 6934) in the Spring. Additional Spring courses include GMS 6040, Host-Pathogen Interactions (1 credit) and GMS 6169, Special Topics Antimicrobial Strategies (1 credit).

A three pack of advanced modules is offered in the Spring (GMS 6034, GMS 6035, GMS 6036). Fall semester advanced modules will include: GMS 6382, Special Topics in Immunology; VME 6505, Autoimmunity; and GMS 6040, Host-Pathogen Interactions.

Journal Club: The Immunology & Microbiology journal club meets each Thursday at 12:00-1:00 p.m. during the Fall semester. All Immunology & Microbiology students are required to register for the Immunology & Microbiology journal club (GMS 6921, Immunology/Microbiology Journal Colloquy) each Fall semester beginning in their second year. Most Fall semester journal club presentations are usually based on a general theme, e.g. vaccines, immune response to infection, emerging pathogens.Immunology & Microbiology students must also register for a journal club in the Spring semester, but they may register for the specialty journal club of their choice, e.g. immunology, bacteriology, virology, HIV, etc.

Meet David Ostrov, Ph.D. and learn about his research on proteins and the identification of druggable targets:

For a list of faculty members currently recruiting graduate students in the Immunology & Microbiology advanced program for 2017-2018, please click here.

For a list of faculty all members in the Immunology & Microbiology advanced program, please click here.

Co-Coordinators, Immunology & Microbiology Advanced Concentration

Scott Tibbets, Ph.D.Graduate CoordinatorDepartment of Molecular Genetics and MicrobiologyPhone: (352) 273-5628 | Email: stibbe@ufl.edu

Clayton E. Mathews, Ph.D.Graduate CoordinatorDepartment of Pathology, Immunology and Laboratory MedicinePhone: (352) 273-9269 | Email: cxm@ulf.edu

Mary-Ellen Davey, Ph.D.Graduate CoordinatorDepartment of Oral BiologyPhone: (352) 273-8858 | Email: MDavey@dental.ufl.edu

Kristyn MinkoffGraduate AdministratorPhone: (352) 273-6380 | Email: MGM-GradEd@mgm.ufl.edu

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Immunology and Microbiology Concentration Graduate ...

Home – CAS – Undergraduate Immunology Program | UAB

Immunology at UAB is an interdisciplinary program between the Department of Microbiology in the School of Medicine and the Department of Biology in the College of Arts and Sciences. It provides an immunology-focused curriculum in addition to a broad-based education in the fundamental aspects of biology, microbiology, chemistry, physics, and mathematics. This curriculum will satisfy most pre-medical and pre-health requirements, making it an ideal choice for those students who have an interest in pursuing careers in:

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Home - CAS - Undergraduate Immunology Program | UAB

Home [immunology.ucsd.edu]

UC San Diego and the La Jolla Institute's unique partnership fosters shared research interests, collaboration, and the application of young scientists to all aspects of host immunity, with the goal of advancing immunological research and further distinguishing the San Diego region as a leader in the field.

The Program converges diverse individual and departmental research efforts from 86 laboratories at UC San Diego's Division of Biological Sciences and School of Medicine and the La Jolla Institute, to cultivate interdisciplinary alliances and effect clinical translation of Immunology research. Our collaboration encompasses a nascent Graduate Program, a Seminar Series, andCollaborative Pilot Grants for joint research projects between UC San Diego and the La Jolla Institute, and applications for postdoctoral and predoctoral training grants.

The Program in Immunology is a collaborative effort joining the resources, faculty, and laboratories of the La Jolla Institute and UC San Diego.

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Home [immunology.ucsd.edu]

S2 Genomics and the RIKEN Center for Integrative Medical Sciences Collaborate on Single-Cell Genomics on Solid Tissues – Financialbuzz.com

S2 Genomics, a manufacturer and provider of automated tissue sample preparation systems, and the RIKEN Center for Integrative Medical Sciences (IMS), a leading genomics research institute, today announced that RIKEN IMS has joined the S2 Genomics Early Technology Access Program to evaluate and further develop single cell sequencing applications on the S2 Genomics Singulator tissue preparation system.

Achieving high-quality single cell data from solid tissues relies upon consistent and reproducible cell or nuclei dissociation procedures. To overcome the challenges often seen with manual cell dissociation methods, S2 Genomics has developed the automated Singulator system to process solid tissue samples into suspensions of cells or nuclei for single-cell analysis.

Current methods of cell isolation are a significant bottleneck for researchers and can lead to inconsistencies in their data. The Singulator automates and standardizes the dissociation of solid tissues and can improve the quality of single-cell and single-nuclei data from a variety of solid tissue types, said Dr. Stevan Jovanovich, President and CEO of S2 Genomics. We are excited to work with the RIKEN IMS to evaluate the performance of the system and to develop new applications for the Singulator platform.

Dr. Aki Minoda, Unit Leader of the Epigenome Technology Exploration Unit, commented on the collaboration: We are delighted to collaborate with S2 Genomics and incorporate the Singulator into our workflow for single-cell analyses.

About S2 Genomics, Inc.

S2 Genomics, founded in 2016, is a leading developer of laboratory automation solutions to process solid tissue for life science applications. S2 Genomics technology platforms integrate advanced fluidics, optics, and biochemistry capabilities to produce sample preparation solutions for the next generation sequencing (NGS) and cell biology markets. For more information, visit http://www.s2genomics.com.

S2 Genomics, the S2 Genomics logo, and Singulator are trademarks of S2 Genomics, Inc.

About the RIKEN Center for Integrative Medical Sciences

The RIKEN IMS aims to elucidate the pathogenesis of human diseases and establish new therapeutic methodologies by conducting cutting-edge research on human genome and immune function. To that end, we have established four Divisions: (1) Division of Genomic Medicine, (2) Division of Human Immunology, (3) Division of Disease Systems Biology, and (4) Division of Next Generation Cancer Immunology. These groups work together to promote state-of-the-art research.

For more information, visit https://www.riken.jp/en/research/labs/ims/index.html.

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S2 Genomics and the RIKEN Center for Integrative Medical Sciences Collaborate on Single-Cell Genomics on Solid Tissues - Financialbuzz.com

Make sure to get the Flu Shot even if you’ve already had the Flu – WFMYNews2.com

GREENSBORO, N.C. If you skipped this years flu shot and then came down with the virus, you may think theres no point in getting the vaccine now.

But youd be wrong.

There are good reasons to get a flu shot, even if youve already been sick this season, says David Topham, Ph.D., a professor of microbiology and immunology at the University of Rochester and director of the New York Influenza Center of Excellence.

Two types commonly make people ill: type A and type B. In the beginning of this flu season, most cases of flu in the U.S. were type B (an unusual development, because type A usually predominates in the early months of a season).

Now, it looks liketype B flu may be beginning to wane while influenza A may be on the rise. And were probably far from done with flu season. According tothe Centers for Disease Control and Preventions latest data, doctors visits due to flu-like illness are still on the rise, though the pace may be slowing. For the first week of February, flu illnesses jumped from 6.7 percent to 6.8 percent of all doctors visits, while in the last week of January, flu illnesses shot up from 5.7 percent to 6.7 percent of all doctors visits.

Flu season looks like it may be starting to level off, but its still going up for the country as a whole, says Lynnette Brammer, M.P.H., an epidemiologist with the CDCs influenza division.

Getting the flu a second time can make you just as miserable as it did the first time around. And the potential for complications with the second infection is just as great as it was with the first.

Those complications can be serious, such as pneumonia and even sepsis, a potentially deadly reaction your body can have to infection.

Flu can also harm your heart. A study published in 2018 in the New England Journal of Medicine found that an individuals heart attack risk was six times higher than usual in the seven days following a positive test for influenza.

This may be of most concern to older adults, especially those with heart disease or who are at higher risk for heart disease because of smoking, diabetes, or other factors, says Jeff Kwong, M.D., lead author of the study and a scientist at the Institute for Clinical Evaluative Sciences in Ontario.

The bottom line: If you havent had one yet,get a flu shot even if you already had the flu (or a bug you think might have been the flu). Although the vaccine doesnt guarantee that youll avoid a second case of the flu, it will reduce the likelihood of it and its complications.

If you did get the vaccine this season, theres no need to get a second one. Scientists believe the protection usually lasts for the whole season.

But if youre still getting over a respiratory illnessor any kind of bugwait until youre fully recovered before going for the flu shot, says Topham at the University of Rochester. When you have another illness, he says, your immune system is focused on the infection that you have and doesnt respond as well to a vaccine.

And keep in mind that if youre starting to recover from the flu and symptoms worsen again, this could signal a secondary infectionsuch as pneumonia,and you should call your doctor right away.

Your hygiene habits can also help stop the spread of flu. Remember to be diligent about washing your hands and covering any coughs or sneezes. Avoid touching your eyes and mouth to keep from transferring any germs that may be on your hands. Keeping air at 30 percent to 50 percent humidity by using a humidifier can help, too; dry air helps the flu virus live longer.

If you do get sick again, stay home to avoid infecting anyone else.

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The way your immune system sees them is very different, Topham says.

Two types commonly make people ill: type A and type B. In the beginning of this flu season, most cases of flu in the U.S. were type B (an unusual development, because type A usually predominates in the early months of a season).

Now, it looks like type B flu may be beginning to wane while influenza A may be on the rise. And were probably far from done with flu season. According to the Centers for Disease Control and Preventions latest data, doctors visits due to flu-like illness are still on the rise, though the pace may be slowing. For the first week of February, flu illnesses jumped from 6.7 percent to 6.8 percent of all doctors visits, while in the last week of January, flu illnesses shot up from 5.7 percent to 6.7 percent of all doctors visits.

Flu season looks like it may be starting to level off, but its still going up for the country as a whole, says Lynnette Brammer, M.P.H., an epidemiologist with the CDCs influenza division.

Getting the flu a second time can make you just as miserable as it did the first time around. And the potential for complications with the second infection is just as great as it was with the first.

Those complications can be serious, such as pneumonia and even sepsis, a potentially deadly reaction your body can have to infection.

Flu can also harm your heart. A study published in 2018 in the New England Journal of Medicine found that an individuals heart attack risk was six times higher than usual in the seven days following a positive test for influenza.

This may be of most concern to older adults, especially those with heart disease or who are at higher risk for heart disease because of smoking, diabetes, or other factors, says Jeff Kwong, M.D., lead author of the study and a scientist at the Institute for Clinical Evaluative Sciences in Ontario.

The bottom line: If you havent had one yet, get a flu shot even if you already had the flu (or a bug you think might have been the flu). Although the vaccine doesnt guarantee that youll avoid a second case of the flu, it will reduce the likelihood of it and its complications.

If you did get the vaccine this season, theres no need to get a second one. Scientists believe the protection usually lasts for the whole season.

But if youre still getting over a respiratory illnessor any kind of bugwait until youre fully recovered before going for the flu shot, says Topham at the University of Rochester. When you have another illness, he says, your immune system is focused on the infection that you have and doesnt respond as well to a vaccine.

And keep in mind that if youre starting to recover from the flu and symptoms worsen again, this could signal a secondary infection such as pneumonia,and you should call your doctor right away.

Your hygiene habits can also help stop the spread of flu. Remember to be diligent about washing your hands and covering any coughs or sneezes. Avoid touching your eyes and mouth to keep from transferring any germs that may be on your hands. Keeping air at 30 percent to 50 percent humidity by using a humidifier can help, too; dry air helps the flu virus live longer.

If you do get sick again, stay home to avoid infecting anyone else.

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Make sure to get the Flu Shot even if you've already had the Flu - WFMYNews2.com