Category Archives: Immunology

Here’s how your body gains immunity to coronavirus – The Guardian

As the daughter of an air force officer and a nurse, I am fascinated by defence systems. There is none more impressive than the human immune system, equipped as it is with a rich arsenal to defend against different types of pathogen. Viruses have evolved to trick, bypass and evade these defences. Our immune systems have, in turn, learned to recognise and deter these virus stealth tactics. In Covid-19, the enemy is a tiny piece of genetic material wearing a lipid coat and a protein crown.

So how is our immune system able to defend against viral infections, and how does this apply to Covid-19? The virus that causes Covid-19 is called severe acute respiratory syndrome coronavirus 2 (Sars-Cov-2), and was first detected in humans around five months ago. It is a coronavirus. Corona, in Latin, means crown. The virus is adorned with an outer layer of protein covered in spikes, like a crown. These spikes help the virus attach itself to target cells. The research community is fast learning about immunity to Covid-19, and we are also applying our knowledge of similar respiratory viruses to predict what to expect in this infection.

Importantly, Covid-19 cannot gain entry to our homes or bodies by itself we have to let it in

Think of a virus as a robot; it cannot reproduce so it needs a factory of materials proteins, lipids and nucleotides to build copies of itself. The coat allows the virus to attach itself to the target cells membrane. The virus then fuses with the cell and releases a shopping list of instructions on how to build and assemble new viruses. This shopping list, the virus genome, is written in nucleotides (RNA). The first job of a virus that enters our bodies is to invade target cells so that it can comfortably remove its coat and deploy its RNA.

Once inside, the virus commandeers the cell and borrows cellular machinery to build more viruses before immune cells detect the intruders and raise the alarm. Antibody proteins that are able to stick to the virus-spike proteins, and prevent attachment to the target cells, are called neutralising antibodies: generating them is often the goal of protective vaccination.

Our infected cells make the ultimate sacrifice and invite their own destruction by displaying distress signals for T-cells, which swiftly detect and kill them. T-cells are cytotoxic powerful serial killers that can recognise peptide fragments of virus displayed on the infected cell surface. When they do, they release a payload of toxic enzymes that kill the infected cell in a kiss of death. This strategic martyrdom is organised by the immune system to deprive the virus of its replication factories and can lead to the reduction of viral load in the patient. It takes several days for antiviral T-cells to expand and antibodies to be generated. Heres the silver lining: memory cells ensure that if we encounter the same virus again, we can react immediately with pre-existing defences. Sars-Cov-2 is new to humanity so we have no protective immunological memory. Vaccines prepared using harmless parts of the virus can help us build protective memory.

The viruss enemy superpower is spreading. The virus achieves this through shedding from infected patients. Sars-Cov-2 is expert at hopping from person to person, and in some people, it achieves a stealthy existence with mild or no symptoms. Once many copies of the virus are made, it needs to jump to another host. It hitches a ride on droplets that can be coughed or sneezed to a distance of up to two metres. Droplets can survive on surfaces for several hours enabling pick-up by a new host, or they can be directly inhaled if another person is in close proximity. Studies are emerging into animal hosts so far the virus has been detected in a few ferrets, cats, tigers and dogs. No animal deaths have yet been reported, and we dont know if animals can transmit back to humans.

The age differential in fatalities for Covid-19 suggests, with some exceptions, that a healthy immune system is usually able to control infection. Meanwhile, an ageing or weakened immune system may struggle to deploy a protective arsenal. Importantly, Sars-Cov-2 cannot gain entry to our homes or bodies by itself we have to let it in. This is why official advice has centred around cleaning our hands and avoiding touching our faces.

We know that a healthy immune system is usually able to eliminate infection in a couple of weeks. However, we have no understanding of the components of our immune arsenal that contribute to this feat: some vaccines work by creating potent neutralising antibodies; other vaccines generate powerful memory T-cells. Antiviral antibodies emerge as early as three to four days after virus detection, but are they protective against future reinfection? We believe that antibodies to other coronaviruses (Sars, Mers) last from one to three years. Because this is a new virus, we dont yet know the answer to this question. Public Health England is recruiting 16,000 to 20,000 volunteers to monitor antibodies once a month for six to 12 months to confirm whether we can generate long-lasting antibody responses to Sars-Cov-2. Determining the quality of these antibodies will be important to understanding long-term protection.

What is our most potent immune weapon against Covid-19? Cytotoxic T-cells may play an important role. Immunologists and virologists are working together to discover the correlates of protection, to design vaccines that offer long-term defences against Covid-19. Years of investment in research means that we can use existing approaches to respond to this new threat, and early mobilisation of research funders, philanthropists and academics are diverting resources to bolster these efforts on an unprecedented scale. Experience has taught us that vaccines are able to eradicate infections from this planet (for instance, smallpox), and medicines against viruses that dont embed their genetic material to our own (for example, hepatitis C) can also achieve this.

Our secret weapon is research. Scientists are working hard on understanding Covid-19, and collaboration is key to this effort. But until a vaccine or treatment is available, we ought to work hard to protect ourselves and our families: isolate and prevent transmission by using physical distancing, face masks and sensible hygiene. If we all do our part, this little virus holding the world to ransom wont stand a chance.

Zania Stamataki is a senior lecturer and researcher in viral immunology at the University of Birmingham

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Here's how your body gains immunity to coronavirus - The Guardian

UGA’s Landon Clark named 2020 Goldwater Scholar – University of Georgia

University of Georgia Honors student Landon Clark is among 396 undergraduates across the nation to be recognized as Barry Goldwater Scholars, earning the highest undergraduate award of its type for the fields of the natural sciences, mathematics and engineering.

Clark, from Leesburg, is a third-year CURO Honors Scholar who is triple majoring in biochemistry and molecular biology, genetics and biology.

Since 1995, 61 UGA students have received the Goldwater Scholarship, which recognizes exceptional sophomores and juniors across the United States.

The University of Georgia is proud of Landon and pleased that he is extending our record of success in this prestigious competition, said President Jere W. Morehead. Already as an undergraduate student, he is helping UGA fulfill our commitment to conduct research that helps people lead longer, healthier lives.

This year, recipients were selected from a field of more than 5,000 college sophomores and juniors who were nominated by 461 academic institutions nationwide. Each awardee will receive up to $7,500 toward the cost of tuition, fees, books, and room and board.

Of this years Goldwater Scholars, 50 are mathematics and computer science majors, 287 are majoring in the natural sciences and 59 are majoring in engineering.

I am thrilled for Landon, who is absolutely one of our very best students, said David S. Williams, associate provost and director of the Honors Program, who serves as the UGA campus faculty representative for the Goldwater Scholarship. As a CURO Honors Scholar, Landon was recruited to come to UGA because of his promise as a researcher. This Goldwater award and recognition proves that his hard work is paying off. I look forward to watching his career continue to blossom in the future.

Clarks long-term plans include pursuing an MD/PhD in immunology, performing translational research on immune diseases using gene and immunotherapy techniques, and teaching at a university. As a translational researcher specializing in immunology, he plans to use gene therapy techniques to treat and cure immune disorders in humans.

Since his first weeks as a UGA freshman in August 2017, Clark has conducted research in the lab of Michael Terns, Distinguished Research Professor of Biochemistry and Molecular Biology. He researches the complex processes of CRISPR-Cas immune systems through a model archaeal organism, Pyrococcus furiosus. Now a junior, he has collaborated on three different projects, co-authored a paper, and mentors other undergraduates in this field.

Last summer, he worked in the translational research lab of H. Trent Spencer, a professor of pediatrics and director of the gene and cell therapy program at Emorys Winship Cancer Institute. There, Clark researched immune diseases and potential gene therapy techniques. In 2017, he also conducted research on sociological variables influencing educational inequality with Dawn Robinson, a professor of sociology at UGA.

Clark is a Crane Leadership Scholar, director of academic outreach for the Student Government Association, director of internal communications for UGA Red Cross, an exam writer for UGA Science Olympiad Outreach, co-president of the Biochemistry Undergraduate Society, co-president of the Omicron Delta Kappa National Honor Society, and treasurer of the Honors Program Student Council. He also volunteers in the neuroscience and cardiology units at Piedmont Athens Regional Medical Center.

Clark has presented his research at 10 conferences. He also studied neurology and cancer biology through UGAs Studies Abroad Program in Cortona, located in Tuscany, Italy.

The scholarship honoring Sen. Barry Goldwater was created to encourage outstanding students to pursue careers in the fields of mathematics, natural sciences and engineering. Since its first award in 1989, the Barry Goldwater Scholarship and Excellence in Education Foundation has bestowed 8,628 scholarships worth more than $68 million.

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UGA's Landon Clark named 2020 Goldwater Scholar - University of Georgia

These Are The Treatments And Cures Colorado Researchers Are Developing For Coronavirus – Colorado Public Radio

In Colorado, doctors and researchers are desperately looking for ways to treat patients with COVID-19.

Right now, there is no proven effective treatment, and it could be many months before a vaccine or a treatment to alleviate symptoms is tested and available for widespread use. Research into some drugs and treatments are farther along than others, and many show signs of promise.

Heres where things stand.

Weve eradicated smallpox and made diseases like the measles manageable through the use of vaccines. Those treatments are some of the biggest breakthroughs in public health, but they require time and money.

The World Health Organization announced in February that a vaccine for SARS-CoV-2, the virus that causes COVID-19, could be ready in 12-18 months, but some scientists argue that the timeline may be unrealistic. Typically, a vaccine can take 5-15 years to be developed, tested in clinical trials, and manufactured for distribution.

Around the country, several biotech companies have started human clinical trials of a vaccine, and its likely that multiple vaccines will be developed.

At Colorado State University, Gregg Dean, professor and head of the Department of Microbiology, Immunology, and Pathology, was working on a vaccine to treat a strain of coronavirus that cats contract when he shifted gears to address the strain thats now causing the pandemic.

Our experience with viruses in animals is quite valuable. This involves work by veterinarians and nonveterinarians to study these viruses in these nonhuman species, Dean said. When we think about the current pandemic, this virus has come out of an animal reservoir and it's jumped into the human population. Our understanding of those animals, the viruses they have and how these sort of emerging pathogens can come about is really critical.

Dean and his team are working on a vaccine made from the bacterium Lactobacillus acidophilus, a probiotic found in yogurt. This bacterium thrives in the mucous membrane the tissues of the nose, mouth, throat and lungs which is where the new coronavirus gains entry into the body.

The researchers engineered a form of the bacterium to block the virus from invading cells, exploiting the viruses Achilles heel.They're still developing the vaccine but hope to begin animal trials in the coming months to determine if it will be a good candidate for humans.

Over in Aurora, Greffex Inc., a Texas-based company, is developing an adenoviral vector-based vaccine. Scientists take an adenovirus, clear it of its disease-causing material and then introduce a part of the virus that causes COVID-19 into the viral shell. When injected into a person, the body will mount a response that results in immunity to the virus without having been exposed to a live or killed virus.

"The benefit is speed to get to the vaccine, cost, because ultimately when you get to production, you want to make a vaccine that's significantly cheaper for the population and safety," said John Price, CEO and president of Greffex Inc. "If you don't use a live virus or a killed virus, you're really not introducing anything that could be harmful to begin with."

Read more about that vaccine here.

Its likely that one of the first treatments well see in widespread use for COVID-19 will be one that uses an already-approved drug, like the antimalarial drugs chloroquine and hydroxychloroquine that President Donald Trump has pushed for.

Drugs that are already approved by the Food and Drug Administration have known side effects and manufacturers know how to produce them, but they arent likely to be the cure-all for COVID-19. These drugs are not likely to cure COVID-19, but they may alleviate the symptoms associated with the infection and keep them from becoming more severe.

Dr. Thomas Campbell, at the CU Anschutz Medical Campus, is working on a clinical trial of sarilumab, an anti-inflammatory drug used to treat rheumatoid arthritis. The trial was developed jointly by the pharmaceutical companies Regeneron and Sanofi. Hospitals all over the country will enroll hundreds of patients. In Colorado, Campbell has enrolled about 15 so far.

Sarilumab blocks the activity of a protein in the body that regulates inflammation. Many patients with severe COVID-19 develop hyperactive inflammation in their lungs. By targeting the inflammation mediator, patients may see improvements with this drug.

The idea is that if you can reduce that inflammation, interfere with that inflammation, then people will get better quicker, Campbell said. If they're not on a ventilator, they might not need to go on the ventilator, or if they're already on mechanical ventilation, they might come off of mechanical ventilation sooner than later.

When someone is exposed to COVID-19, the virus attacks the bodys cells and then starts to replicate itself. That replication process is what allows the virus to spread in the body and make us sick by damaging other cells or disrupting cell function.

Antiviral inhibitors prevent the virus from replicating, stopping or slowing the spread and allowing the body to catch up and recover. Campbell said UCHealth will start clinical trials of remdesivir, developed by the drug company Gilead Biosciences, in the coming weeks. One trial will focus on patients who have mild to moderate symptoms, and the second trial will focus on more severe patients.

Jed Lampe, assistant professor in the Department of Pharmaceutical Sciences at the Anschutz Medical Campus, is working on an antiviral inhibitor used to treat HIV. He and his team are modifying the drugs ritonavir and lopinavir. Lampe said there is some clinical evidence that they may be useful against COVID-19.

What's nice about taking this approach where we're starting out using these old inhibitors that were very effective at treating the HIV virus to treat this virus is that we know that they are already safe and effective at least against that virus, Lampe said.

But for the inhibitors to be effective against the novel coronavirus, Lampe and his team are having to make changes to the shape of the inhibitor so that it better fits this virus. One problem with antiviral inhibitors is that as the virus mutates, the inhibitor becomes less effective. In treating HIV, doctors use a cocktail of drugs for this reason.

We hope that this iterative process that that'll lead to a library of compounds that we can use to treat the viruses that haven't even been identified yet, or mutant viruses in the future, he said.

Listen to Colorado Matters interview with Lampe.

When you get sick with a cold or the flu, or even when you have an allergic reaction, your body reacts and creates antibodies. Those antibodies are part of your immune response when youre exposed to that virus or allergen in the future. For COVID-19 patients, receiving the plasma from someone who has recovered from the virus can help their body to fight off the disease.

COVID-19 convalescent plasma has been used by doctors at UCHealth to treat severe cases, and its showing promise.

There is hope in this treatment, said Dr. Kyle Annen, medical director of the blood collection center at Childrens Hospital of Colorado. However, it's not a certainty. We don't know for sure that it is the best option or the only option. It may be a great option with other medications. There may be another medication that comes along that is identified to work better. But it's great that we have this one additional thing in our arsenal to try to fight COVID-19.

Theres anecdotal evidence that plasma was used to treat sick people during the 1918 Spanish Flu, and it was used successfully to treat H1N1 flu in 2009-2010, but in other cases, its not been effective. The Food and Drug Administration released its guidelines for giving convalescent plasma to COVID-19 patients, and has encouraged researchers to begin clinical trials to investigate its efficacy.

Read more about that here.

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These Are The Treatments And Cures Colorado Researchers Are Developing For Coronavirus - Colorado Public Radio

When will we reopen the country? Antibody testing may help officials decide, experts say – USA TODAY

The coronavirus (COVID-19) is impacting the global economy and raising fears of a recession. What causes a recession and what are the signs? USA TODAY

As officials begin to discusswhen they can lift stay-at-home orders, companies are rushing to develop coronavirus antibody tests that could help them make those decisions without risking a second wave of infections.

Leading the fight against COVID-19, Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said Friday morning on CNN that antibody testing can show who has developed immunityto the coronavirus and can safely go back to work without getting reinfected.

As we get to the point of at least considering opening up the country, as it were, its very important to appreciate and understand how much this virus is penetrating this society, he said.

How would antibody tests factor into decisions to lift social distancing orders, and how reliable arethose tests? Here's everything you need to know about antibody testing.

Testing to see if people haveantibodies in their blood isnt the same as testing to see if they have been infected withthe coronavirus that causes COVID-19.

The antibody test can determine if someone was previously infectedand recovered, whereas the moleculartest shows whether that person was infected with the virus at the time the test was taken.

Antibodies are the bodys way of remembering how it responded to an infection so it can attack again if exposed to the same pathogen. If a person has antibodies in his blood, that means he hasimmune cells available to fight the virus, which lowers therisk of re-infection.

Antibody tests look for two antibodies in the blood, immunoglobulin M (IgM) and immunoglobulin G (IgG). IgM antibodies are the first line of defense, appearing within several days of infection. IgG antibodies come later, as the body is clearing up the infection.

IgM and IgG antibodies fight all kinds of infections. The blood tests for COVID-19 look for a protein particular to this coronavirus, which shows whether the body is producing antibodies to itand not, for example, the seasonal flu.

Marc Lipsitch, a professor of epidemiology at Harvard and an expert in public health interventions, told the USA TODAY Editorial Board on Wednesday that a significant portion of the population must be immune to the coronavirus before social distancing restrictions can be lifted. Widespread antibody testing can determine how many people carry the antibodies.

Antibody tests can reveal who is immune to a disease, but it can also determine how widely it has spread and how deadly it is.

Dr. Neeraj Sood, professor and vice dean of research and faculty at the University of Southern California Sol Price School of Public Policy, isleading a study in conjunction with the Los Angeles County Department of Public Health using antibody tests to answer that question.

There have been 223 deaths related to COVID-19in the county, according to the health department. If, based on the antibody study, researchers determine that about 2,500 people had been infected,it would be considered a deadly disease. But if more than 2 million people had been infected, it wouldn't be considered that dangerous.

If we find out COVID is far less deadly than the flu, we can open up the economy. You dont need to hit herd immunity to open it up. Sood said. But if you find out that COVID is 10 times deadlier than the flu, then you have to keep it closed.

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Antibody testing combined with the molecular coronavirus testcan determine if a person is immune and can transmit the disease, he said.This is crucial in deciding who can go back to work.

Those who are immune and cant transmit the disease can be on the front lines of the epidemic, keeping daily life afloatin grocery stores, hospitals and other essential businesses,Sood said.

Antibody tests can also identify people who had COVID-19 but didn't have any symptoms a group that may be much larger than we know.

Theres some data out there that 15% to 16% of kids have had asymptomatic infections. They could be the secret spreaders. But without tests, we dont know, said Mark Slifka, a professor of viral immunology at Oregon Health and Science University in Portland, Oregon.

Doing broad testing of even a portion of the population in the coming months could also give researchers a sense of how much of the U.S. populationwas infected this year. They could use that to predict who might be immune if the virus comes back again thisfall, said Slifka.

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Immunity to viruses can last from months to a lifetime.William Schaffner, a professor of preventive medicine and infectious disease at Vanderbilt University, expects that contracting the coronavirus once would likely give someone pretty solid protection for a year. But he cautioned predictions for a newly emerged virus are difficult to make.

We dont know that this new coronavirus has read the textbook and knows what its supposed to do, he said.

On the TODAY show Thursday, Fauci said a large number of antibody tests should be available in a matter of days or weeks, according to the companies developing them.

Dr. Elitza Theel, directorof theInfectious Diseases Serology Laboratory at the Mayo Clinic, said laboratories throughout the country have been working to validate and select antibody tests.

She expects they will be widely available in about one to three weeks.

Cellex Inc. of Research Triangle Park in North Carolina was the first company to receive emergency use authorization of its test by the U.S. Food and Drug Administration last week.

Over50 commercial manufacturers are seeking FDA approval forantibody tests, Theel said.

ButDr. Raed Dweik, chairman of the Respiratory Institute at the Cleveland Clinic, saidsome of the tests he's seen aren't accurateenough to determine if someone is truly immune to the coronavirus.

This is becauseantibodies for the coronavirus that causes COVID-19 look very similar to antibodies that respond to coronaviruses that cause other illnesses, such as the common cold.

Tests could mistakenly identify antibodies as being for the coronavirus that causes COVID-19, producing a false positive. Dweik said it will take more time to develop a test that can accurately detect the right antibodies.

"The timing is tricky," he said. "Developing this test has been fraught with problems."

In addition, scientists don't know a lot about the protective value of coronavirus antibodies, said Dr. Carlos del Rio, an infectious disease expert and executive associate dean at Emory University.The test to identify HIV, for example, is an antibody test. "Having those antibodies doesn't necessarily mean immunity," he said.

Few of the coronavirus antibody tests have been vetted to determinetheir clinical accuracy, Theel said. No test is 100 percent accurate, she said, and it's up to the clinical laboratories to decidewhich ones are best for their patients.

"It's one of the biggest concerns right now because there's so many tests out there and we dont know how the vast majority of them work," she said.

Contributing: Letitia Stein andElizabeth Weise, USA TODAY.Follow Adrianna Rodriguez on Twitter: @AdriannaUSAT.

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When will we reopen the country? Antibody testing may help officials decide, experts say - USA TODAY

Trinity and AIB join forces for dedicated Covid-19 Research Hub – Siliconrepublic.com

AIB has pledged 2.4m to help accelerate Trinity College Dublins immunology project tackling the Covid-19 pandemic.

Trinity College Dublin will establish a new research hub at the university in collaboration with AIB, after the bank pledged 2.4m to accelerate the project.

The new research hub will be located within the Trinity Biomedical Sciences Institute and will play a critical role in the delivery of the Trinity Covid-19 Immunology Project. The hub will involve immunologists and infectious disease clinicians from St Jamess Hospital in Dublin.

While the immunology project was already in the pipeline, this injection of funding has accelerated plans.The project will be a collaboration with the Trinity Translational Medicine Institute and the Clinical Research Facility based on the St Jamess Hospital campus.

AIBs CEO, Colin Hunt, said its an ambitious and pioneering project that merits every assistance in developing solutions for the short, medium and long term. Time is of the essence and our support for the research hub begins now, he added.

The research will focus on addressing the design of new drugs and vaccines, the supply and validation of commercial antibody testing kits, the development of rapid antibody testing and the investigation of the immune response in infected and recovered Covid-19 patients.

The project will be led by Prof Kingston Mills and Prof Aideen Long and will involve scientists and immunologists working on basic and applied research, including infectious disease consultants, immunologists, respiratory disease physicians and intensive care specialists working with Covid-19 patients.

Mills said: This will provide key information for the design of vaccines and immunotherapeutic drugs for controlling the often fatal inflammation in Covid-19 patients, and will assist in developing and validating new assays for detecting antibody responses to the virus, thereby identifying those that are immune and therefore safe to return to work.

The research will also benefit from Trinitys global network of collaborations and contacts in universities such as MIT in Boston and Utrecht University in The Netherlands. The hub will continue to accept contributions from other public and private sources.

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Trinity and AIB join forces for dedicated Covid-19 Research Hub - Siliconrepublic.com

UB researchers step up to help break bottlenecks in COVID-19 testing – UB Now: News and views for UB faculty and staff – University at Buffalo…

Its a national issue: not enough tests or testing materials for COVID-19. To most of us, its another thing that feels awful, but out of our control during this unprecedented global pandemic.To members of the research community, its a call to action.Anthony A. Campagnari, SUNY Distinguished Professor in the Department of Microbiology and Immunology, heard that call when a colleague sent an email noting a need for more viral transport media, or VTM. Campagnari and his colleagues throughout the Jacobs School of Medicine and Biomedical Sciences at UB quickly teamed up. The result? They are now providing Kaleida Health with approximately 1,000 tubes of VTM each week.The email came from John Tomaszewski, SUNY Distinguished Professor and Peter A. Nickerson, PhD, Chair of the Department of Pathology and Anatomical Sciences in the Jacobs School and clinical chief of service at Kaleida Health Laboratories, a position that puts him at the heart of the COVID-19 testing process for Kaleida Health.They were fortunate: Kaleida Health had agreed years before to host at its Center for Laboratory Medicine an important piece of laboratory instrumentation called a polymerase chain reaction (PCR) machine. The machine allows for the detection of viral nucleic acids, and the methodology can be designed to specifically identify COVID-19 in clinical samples. The machine was provided by Abbott Laboratories to support the clinical research of Andrew Talal, professor of medicine in the Jacobs School and a leading researcher on hepatitis C virus.There have been issues with laboratory testing capacity everywhere, says Tomaszewski, also president of UBMD Pathology. This partnership between UB and Kaleida Health came about because of the clinical trial research of one of our faculty members and now its become a critical piece of the communitys COVID-19 response.Adds Talal: This was an opportunity for research and clinical care to proceed harmoniously, so that during this pandemic, we could take advantage of the placement of this machine within Kaleida as a research tool. The machine has traditionally been used to measure the level of hepatitis C virus in the blood and liver, investigation that is supported by the Kaleida Health Foundation. This is an illustration of how the foundations support is directly enabling us to improve the health of the community.We have leveraged this machine to do testing for COVID-19 and its the only reason we are doing any testing, Tomaszewski notes. This is because of the UB academic health center partnership and the interaction between the clinical research at UB and the clinical treatment thats going on at Kaleida Health.

But while the machine increased the areas testing capacity, there was not enough viral transport media (VTM) to support the samples that needed testing.In the current COVID-19 pandemic, the nasopharyngeal swab that is used to take a sample from the patient is placed directly into a tube of sterile VTM, says Campagnari, senior associate dean for research in the Jacobs School. So every COVID-19 test that involves a nasal swab utilizes VTM.Viral transport media are critical for any tests involving viral detection, he explains; this media contains proteins that stabilize the virus until the sample can be properly analyzed. VTM includes buffers to control pH, as well as antibiotics and antifungals to prevent or eliminate bacteria or fungi from contaminating the clinical sample.Other Jacobs School colleagues were reaching out, too. Jay Bangs, chair microbiology and immunology, sent an email asking if anyone had the chemical reagents needed to make the VTM.Almost immediately, faculty responded. Elsa Bou Ghanem, an assistant professor in the department, provided enough Hanks Balanced Salt Solution and heat-inactivated Fetal Bovine Serum, two major components in VTM, to make approximately 25 liters enough for 8,000 tubes.Inquiries about additional reagents resulted in more donations from the Department of Biochemistry Stockroom, thanks to Mark OBrian, chair of biochemistry, and staffers Amy Raslawsky and Dawn Rowland, who provided the essential antibiotic.Campagnari then connected with Nicholas Ingrao at Kaleida labs, who provided the antifungal agent they needed to complete the VTM. Nicole Luke-Marshall, research assistant professor, and Lisa Hansen, both of whom are part of Campagnaris lab group and have extensive experience in proper sterile technique, also volunteered to help.It was truly amazing how quickly everyone came together, says Campagnari. Within a few days, we had all the essential reagents, we had assembled a team and we were making VTM.

Campagnari and his team followed what they termed a simple recipe, adding each reagent at the proper concentration, filter sterilizing the solution and then portioning 3 milliliters of VTM into 15 milliliters sterile tubes. It requires working in a biosafety cabinet with an automatic pipettor and disposable pipettes. Again, Campagnari says, they were fortunate because Tom Russo, professor and chief of the Division of Infectious Disease in the Department of Medicine, and Chelsie Armbruster, assistant professor of microbiology and immunology, let them use their biosafety cabinets. As we now had three biosafety cabinets, we were also able to practice social distancing while making the VTM, he adds.

Once the samples are prepared, each tube must be properly labelled.While it is somewhat tedious and time consuming, it is not difficult, Campagnari says.He notes that other regions experiencing VTM shortages should identify research labs in the vicinity that also might be able to help.Campagnaris team at the Jacobs School has now committed to providing Kaleida Health with about 1,000 tubes of VTM per week for as long as necessary.Many individuals from the Jacobs School rapidly responded to this shortage by dedicating their time, their reagents and their facilities, which is an excellent example of teamwork involving a combination of both clinical and basic science expertise, Campagnari says.

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One Hundred Years of Crisis – Journal #108 April 2020 – E-Flux

If philosophy ever manifested itself as helpful, redeeming, or prophylactic, it was in a healthy culture. The sick, it made ever sicker.Nietzsche, Philosophy in the Tragic Age of the Greeks

In 1919, after the First World War, the French poet Paul Valry in Crisis of the Spirit wrote: We later civilizations we too know that we are mortal.1 It is only in such a catastrophe, and as an aprs coup, that we know we are nothing but fragile beings. One hundred years later, a bat from Chinaif indeed the coronavirus comes from batshas driven the whole planet into another crisis. Were Valry still alive, he wouldnt be allowed to walk out of his house in France.

The crisis of the spirit in 1919 was preceded by a nihilism, a nothingness, that haunted Europe before 1914. As Valry wrote of the intellectual scene before the war: I see nothing! Nothing and yet an infinitely potential nothing. In Valrys 1920 poem Le Cimetire Marin (Graveyard by the Sea) we read a Nietzschean affirmative call: The wind is rising! We must try to live! This verse was later adopted by Hayao Miyazaki as the title of his animation film about Jiro Horikoshi, the engineer who designed fighter aircraft for the Japanese Empire that were later used in the Second World War. This nihilism recursively returns in the form of a Nietzschean test: a demon invades your loneliest loneliness and asks if you want to live in the eternal recurrence of the samethe same spider, the same moonlight between the trees, and the same demon who asks the same question. Any philosophy that cannot live with and directly confront this nihilism provides no sufficient answer, since such a philosophy only makes the sick culture sicker, or in our time, withdraws into laughable philosophical memes circulating on social media.

The nihilism Valry contested has been constantly nurtured by technological acceleration and globalization since the eighteenth century. As Valry wrote towards the end of his essay:

But can the European spiritor at least its most precious contentbe totally diffused? Must such phenomena as democracy, the exploitation of the globe, and the general spread of technology, all of which presage a deminutio capitis for Europe must these be taken as absolute decisions of fate?2

This threat of diffusionwhich Europe may have attempted to affirmis no longer something that can be confronted by Europe alone, and probably will never be completely overcome again by the European tragist spirit.3 Tragist is first of all related to Greek tragedy; it is also the logic of the spirit endeavoring to resolve contradictions arising from within. In What Begins after the End of the Enlightenment? and other essays, I have tried to sketch out how, since the Enlightenment, and after the decline of monotheism, the latter was replaced by a mono-technologism (or techno-theism), which has culminated today in transhumanism.4 We, the moderns, the cultural heirs to the European Hamlet (who, in Valrys Crisis of the Spirit, looks back at the European intellectual legacy by counting the skulls of Leibniz, Kant, Hegel, and Marx), one hundred years after Valrys writing, have believed and still want to believe that we will become immortal, that we will be able to enhance our immune system against all viruses or simply flee to Mars when the worst cases hit. Amidst the coronavirus pandemic, researching travel to Mars seems irrelevant for stopping the spread of the virus and saving lives. We mortals who still inhabit this planet called earth may not have the chance to wait to become immortal, as the transhumanists have touted in their corporate slogans. A pharmacology of nihilism after Nietzsche is still yet to be written, but the toxin has already pervaded the global body and caused a crisis in its immune system.

For Jacques Derrida (whose widow, Marguerite Derrida, recently died of coronavirus), the September 11, 2001 attack on the World Trade Center marked the manifestation of an autoimmune crisis, dissolving the techno-political power structure that had been stabilized for decades: a Boeing 767 was used as a weapon against the country that invented it, like a mutated cell or virus from within.5 The term autoimmune is only a biological metaphor when used in the political context: globalization is the creation of a world system whose stability depends on techno-scientific and economic hegemony. Consequently, 9/11 came to be seen as a rupture which ended the political configuration willed by the Christian West since the Enlightenment, calling forth an immunological response expressed as a permanent state of exceptionwars upon wars. The coronavirus now collapses this metaphor: the biological and the political become one. Attempts to contain the virus dont only involve disinfectant and medicine, but also military mobilizations and lockdowns of countries, borders, international flights, and trains.

In late January, Der Spiegel published an issue titled Coronavirus, Made in China: Wenn die Globalisierung zur tdlichen Gefahr wird (When globalization becomes deadly danger), illustrated with an image of a Chinese person in excessive protective gear gazing at an iPhone with eyes almost closed, as if praying to a god.6 The coronavirus outbreak is not a terrorist attackso far, there has been no clear evidence of the viruss origin beyond its first appearance in Chinabut is rather an organological event in which a virus attaches to advanced transportation networks, travelling up to 900 km per hour. It is also an event that seems to return us to the discourse of the nation-state and a geopolitics defined by nations. By returning, I mean that, first of all, the coronavirus has restored meaning to borders that were seemingly blurred by global capitalism and the increasing mobility promoted by cultural exchange and international trade. The global outbreak has announced that globalization so far has only cultivated a mono-technological culture that can only lead to an autoimmune response and a great regression. Secondly, the outbreak and the return to nation-states reveal the historical and actual limit of the concept of the nation-state itself. Modern nation-states have attempted to cover up these limits through immanent infowars, constructing infospheres that move beyond borders. However, rather than producing a global immunology, on the contrary, these infospheres use the apparent contingency of the global space to wage biological warfare. A global immunology that we can use to confront this stage of globalization is not yet available, and it may never become available if this mono-technological culture persists.

During the 2016 refugee crisis in Europe, the philosopher Peter Sloterdijk criticized Germanys chancellor Angela Merkel in an interview with the magazine Cicero, saying, We have yet to learn to glorify borders Europeans will sooner or later develop an efficient common border policy. In the long run the territorial imperative prevails. After all, there is no moral obligation to self-destruction.7 Even if Sloterdijk was wrong in saying that Germany and the EU should have closed their borders to refugees, in retrospect one may say that he was right about the question of borders not being well thought out. Roberto Esposito has clearly stated that a binary (polar) logic persists concerning the function of borders: one insists on stricter control as an immunological defense against an outer enemya classical and intuitive understanding of immunology as opposition between the self and the otherwhile the other proposes the abolition of borders to allow freedom of mobility and possibilities of association for individuals and goods. Esposito suggests that neither of the two extremesand it is somewhat obvious todayis ethically and practically undesirable.8

The outbreak of the coronavirus in Chinabeginning in mid-November until an official warning was announced in late January, followed by the lockdown of Wuhan on January 23led immediately to international border controls against Chinese or even Asian-looking people in general, identified as carriers of the virus. Italy was one of the first countries to impose a travel ban on China; already in late January, Romes Santa Cecilia Conservatory suspended oriental students from taking classes, even those who had never in their life been to China. These actswhich we may call immunologicalare conducted out of fear, but more fundamentally out of ignorance.

In Hong Kongright next to Shenzhen in Guangdong province, one of the major outbreak regions outside Hubei provincethere were strong voices urging the government to close the border with China. The government refused, citing the World Health Organization advising countries to avoid imposing travel and trade restrictions on China. As one of two special administrative regions of China, Hong Kong SAR is not supposed to oppose China nor add to its recent burden of underwhelming economic growth. And yet, some Hong Kong restaurants posted notices on their doors announcing that Mandarin-speaking clients were unwelcome. Mandarin is associated with virus-carrying Mainland Chinese people, therefore the dialect is considered a sign of danger. A restaurant that under normal circumstances is open to anyone who can afford it is now only open to certain people.

All forms of racism are fundamentally immunological. Racism is a social antigen, since it clearly distinguishes the self and the other and reacts against any instability introduced by the other. However, not all immunological acts can be considered racism. If we dont confront the ambiguity between the two, we collapse everything into the night where all cows are grey. In the case of a global pandemic, an immunological reaction is especially unavoidable when contamination is facilitated by intercontinental flights and trains. Before the closing of Wuhan, five million inhabitants had escaped, involuntarily transporting the virus out of the city. In fact, whether one is labelled as being from Wuhan is irrelevent, since everyone can be regarded as suspect, considering that the virus can be latent for days on a body without symptoms, all the while contaminating its surroundings. There are immunological moments one cannot easily escape when xenophobia and micro-fascisms become common on streets and in restaurants: when you involuntarily cough, everyone stares at you. More than ever, people demand an immunospherewhat Peter Sloterdijk suggestedas protection and as social organization.

It seems that immunological acts, which cannot simply be reduced to racist acts, justify a return to bordersindividual, social, and national. In biological immunology as well as political immunology, after decades of debate on the selfother paradigm and the organismic paradigm, modern states return to border controls as the simplest and most intuitive form of defense, even when the enemy is not visible.9 In fact, we are only fighting against the incarnation of the enemy. Here, we are all bound by what Carl Schmitt calls the political, defined by the distinction between friend and enemya definition not easily deniable, and probably strengthened during a pandemic. When the enemy is invisible, it has to be incarnated and identified: firstly the Chinese, the Asians, and then the Europeans, the North Americans; or, inside China, the inhabitants of Wuhan. Xenophobia nourishes nationalism, whether as the self considering xenophobia an inevitable immunological act, or the other mobilizing xenophobia to strengthen its own nationalism as immunology.

The League of Nations was founded in 1919 after the First World War, and was later succeeded by the United Nations, as a strategy to avoid war by gathering all nations into a common organization. Perhaps Carl Schmitts criticism of this attempt was accurate in claiming that the League of Nations, which had its one-hundred-year anniversary last year, mistakenly identified humanity as the common ground of world politics, when humanity is not a political concept. Instead, humanity is a concept of depoliticization, since identifying an abstract humanity which doesnt exist can misuse peace, justice, progress, and civilization in order to claim these as ones own and to deny the same to the enemy.10 As we know, the League of Nations was a group of representatives from different countries that was unable to prevent one of the greatest catastrophes of the twentieth century, the Second World War, and was therefore replaced by the United Nations. Isnt the argument applicable to the World Health Organization, a global organization meant to transcend national borders and provide warnings, advice, and governance concerning global health issues? Considering how the WHO had virtually no positive role in preventing the spread of coronavirusif not a negative role: its general director even refused to call it a pandemic until it was evident to everyonewhat makes the WHO necessary at all? Naturally, the work of professionals working in and with the organization deserves enormous respect, yet the case of the coronavirus has exposed a crisis in the political function of the larger organization. Worse still, we can only criticize such a gigantic money-burning global governing body for its failure on social media, like shouting into the wind, but no one has the capacity to change anything, as democratic processes are reserved for nations.

If we follow Schmitt, the WHO is primarily an instrument of depoliticization, since its function to warn of coronavirus could have been done better by any news agency. Indeed, a number of countries acted too slowly by following the WHOs early judgment of the situation. As Schmitt writes, an international representational governing body, forged in the name of humanity, does not eliminate the possibility of wars, just as it does not abolish states. It introduces new possibilities for wars, permits wars to take place, sanctions coalition wars, and by legitimizing and sanctioning certain wars it sweeps away many obstacles to war.11 Isnt the manipulation of global governance bodies by world powers and transnational capital since the Second World War only a continuation of this logic? Hasnt this virus that was controllable at the beginning sunken the world into a global state of war? Instead, these organizations contribute to a global sickness where mono-technological economic competition and military expansion are the only aim, detaching human beings from their localities rooted in the earth and replacing them with fictive identities shaped by modern nation-states and infowars.

The concept of the state of exception or state of emergency was originally meant to allow the sovereign to immunize the commonwealth, but since 9/11 it had tended towards a political norm. The normalization of the state of emergency is not only an expression of the absolute power of the sovereign, but also of the modern nation-state struggling and failing to confront the global situation by expanding and establishing its borders through all available technological and economic means. Border control is an effective immunological act only if one understands geopolitics in terms of sovereigns defined by borders. After the Cold War, increasing competition has resulted in a mono-technological culture that no longer balances economic and technological progress, but rather assimilates them while moving towards an apocalyptic endpoint. Competition based on mono-technology is devastating the earths resources for the sake of competition and profit, and also prevents any player from taking different paths and directionsthe techno-diversity that I have written about extensively. Techno-diversity doesnt merely mean that different countries produce the same type of technology (mono-technology) with different branding and slightly different features. Rather, it refers to a multiplicity of cosmotechnics that differ from each other in terms of values, epistemologies, and forms of existence. The current form of competition that uses economic and technological means to override politics is often attributed to neoliberalism, while its close relative transhumanism considers politics only a humanist epistemology soon to be overcome through technological acceleration. We arrive at an impasse of modernity: one cannot easily withdraw from such competition for fear of being surpassed by others. It is like the metaphor of modern man that Nietzsche described: a group permanently abandons its village to embark on a sea journey in pursuit of the infinite, but arrive at the middle of the ocean only to realize that the infinite is not a destination.12 And there is nothing more terrifying than the infinite when there is no longer any way of turning back.

The coronavirus, like all catastrophes, may force us to ask where we are heading. Though we know we are only heading to the void, still, we have been driven by a tragist impulse to try to live. Amidst intensified competition, the interest of states is no longer with their subjects but rather economic growthany care for a population is due to their contributions to economic growth. This is self-evident in how China initially tried to silence news about the coronavirus, and then, after Xi Jinping warned that measures against the virus damage the economy, the number of new cases dramatically dropped to zero. It is the same ruthless economic logic that made other countries decide to wait and see, because preventive measures such as travel restrictions (which the WHO advised against), airport screenings, and postponing the Olympic Games impact tourism.

The media as well as many philosophers present a somewhat naive argument concerning the Asian authoritarian approach and the allegedly liberal/libertarian/democratic approach of Western countries. The Chinese (or Asian) authoritarian wayoften misunderstood as Confucian, though Confucianism is not at all an authoritarian or coercive philosophyhas been effective in managing the population using already widespread consumer surveillance technologies (facial recognition, mobile data analysis, etc.) to identify the spread of the virus. When the outbreaks started in Europe, there was still debate on whether to use personal data. But if we are really to choose between Asian authoritarian governance and Western liberal/libertarian governance, Asian authoritarian governance appears more acceptable for facing further catastrophes, since the libertarian way of managing such pandemics is essentially eugenicist, allowing self-selection to rapidly eliminate the older population. In any case, all of these cultural essentialist oppositions are misleading, since they ignore the solidarities and spontaneity among communities and peoples diverse moral obligations to the elderly and family; yet this type of ignorance is necessary for vain expressions of ones own superiority.

But where else can our civilization move? The scale of this question mostly overwhelms our imagination, leaving us to hope, as a last resort, that we can resume a normal life, whatever this term means. In the twentieth century, intellectuals looked for other geopolitical options and configurations to surpass the Schmittian concept of the political, as Derrida did in his Politics of Friendship, where he responded to Schmitt by deconstructing the concept of friendship. Deconstruction opens an ontological difference between friendship and community to suggest another politics beyond the friendenemy dichotomy fundamental to twentieth-century political theory, namely hospitality. Unconditional and incalculable hospitality, which we may call friendship, can be conceived in geopolitics as undermining sovereignty, like when the Japanese deconstructionist philosopher Kjin Karatani claimed that the perpetual peace dreamed of by Kant would only be possible when sovereignty could be given as a giftin the sense of a Maussian gift economy, which would follow the global capitalist empire.13 However, such a possibility is conditioned by the abolition of sovereignty, in order words, the abolition of nation-states. For this to happen, according to Karatani, we would probably need a Third World War followed by an international governing body with more power than the United Nations. In fact, Angela Merkels refugee policy and the one country, two systems brilliantly conceived by Deng Xiaoping are moving towards this end without war. The latter has the potential to become an even more sophisticated and interesting model than the federal system. However the former has been a target of fierce attacks and the latter is in the process of being destroyed by narrow-minded nationalists and dogmatic Schmittians. A Third World War will be the quickest option if no country is willing to move forward.

Before that day arrives, and before an even more serious catastrophe brings us closer to extinction (which we can already sense), we may still need to ask what an organismic global immune system could look like beyond simply claiming to coexist with the coronavirus.14 What kind of co-immunity or co-immunism (the neologism that Sloterdijk proposed) is possible if we want globalization to continue, and to continue in a less contradictory way? Sloterdijks strategy of co-immunity is interesting but politically ambivalentprobably also because it is not sufficiently elaborated in his major worksoscillating between a border politics of the far-right Alternative fr Deutschland (AfD) party and Roberto Espositos contaminated immunity. However, the problem is that if we still follow the logic of nation-states, we will never arrive at a co-immunity. Not only because a state is not a cell nor an organism (no matter how attractive and practical this metaphor is for theorists), but also more fundamentally because the concept itself can only produce an immunity based on friend and enemy, regardless of whether it assumes the form of international organizations or councils. Modern states, while composed of all their subjects like the Leviathan, have no interest beyond economic growth and military expansion, at least not before the arrival of a humanitarian crisis. Haunted by an imminent economic crisis, nation-states become the source (rather than the target) of manipulative fake news.

Lets return here to the question of borders and question the nature of this war we are fighting now, which UN Secretary-General Antnio Guterres considers the biggest challenge the UN has faced since the Second World War. The war against the virus is first of all an infowar. The enemy is invisible. It can only be located through information about communities and the mobility of individuals. The efficacy of the war depends on the ability to gather and analyze information and to mobilize available resources to achieve the highest efficiency. For countries exercising strict online censorship, it is possible to contain the virus like containing a sensitive keyword circulating on social media. The use of the term information in political contexts has often been equated with propaganda, though we should avoid simply seeing it as a question of mass media and journalism, or even freedom of speech. Infowar is twenty-first century warfare. It is not a specific type of war, but war in its permanence.

In his lectures collected in Society Must Be Defended, Michel Foucault inverted Carl von Clausewitzs aphorism war is the continuation of politics by other means into politics is the continuation of war by other means.15 While the inversion proposes that war no longer assumes the form Clausewitz had in mind, Foucault hadnt yet developed a discourse on infowar. More than twenty years ago, a book titled Wars without Limit (, officially translated as Unrestricted Warfare or Warfare beyond Bounds) was published in China by two former senior air force colonels. This book was soon translated into French, and is said to have influenced the Tiqqun collective and later the Invisible Committee. The two former colonelswho know Clausewitz well but havent read Foucaultarrived at the claim that traditional warfare would slowly fade away, to be replaced by immanent wars in the world, largely introduced and made possible by information technology. This book could be read as an analysis of the US global war strategy, but also more importantly as a penetrating analysis of how infowar redefines politics and geopolitics.

The war against coronavirus is at the same time a war of misinformation and disinformation, which characterizes post-truth politics. The virus may be a contingent event that triggered the present crisis, but the war itself is no longer contingent. Infowar also opens two other (to some extent pharmacological) possibilities: first, warfare that no longer takes the state as its unit of measure, instead constantly deterritorializing the state with invisible weapons and no clear boundaries; and second, civil war, which takes the form of competing infospheres. The war against coronavirus is a war against the carriers of the virus, and a war conducted using fake news, rumors, censorship, fake statistics, misinformation, etc. In parallel to the US using Silicon Valley technology to expand its infosphere and penetrate most of the earths population, China has also built one of the largest and most sophisticated infospheres in the world, with well-equipped firewalls consisting of both humans and machines, which has allowed it to contain the virus within a population of 1.4 billion. This infosphere is expanding thanks to the infrastructure of Chinas One Belt, One Road initiative, as well as its already established networks in Africa, causing the US to respond, in the name of security and intellectual property, by blocking Huawei from extending its infosphere. Of course, infowar is not waged only by sovereigns. Within China, different factions compete against each other through official media, traditional media such as newspapers, and independent media outlets. For instance, both the traditional media and independent media fact-checked state figures on the outbreak, forcing the government to redress their own mistakes and distribute more medical equipment to hospitals in Wuhan.

The coronavirus renders explicit the immanence of infowar through the nation-states necessity to defend its physical borders while extending technologically and economically beyond them to establish new borders. Infospheres are constructed by humans, and, in spite of having greatly expanded in recent decades, remain undetermined in their becoming. Insofar as the imagination of co-immunityas a possible communism or mutual aid between nationscan only be an abstract solidarity, it is vulnerable to cynicism, similar to the case of humanity. Recent decades have seen some philosophical discourses succeed in nurturing an abstract solidarity, which can turn into sect-based communities whose immunity is determined through agreement and disagreement. Abstract solidarity is appealing because it is abstract: as opposed to being concrete, the abstract is not grounded and has no locality; it can be transported anywhere and dwell anywhere. But abstract solidarity is a product of globalization, a meta-narrative (or even metaphysics) for something that has long since confronted its own end.

True co-immunity is not abstract solidarity, but rather departs from a concrete solidarity whose co-immunity should ground the next wave of globalization (if there is one). Since the start of this pandemic, there have been countless acts of true solidarity, where it matters greatly who will buy groceries for you if you are not able to go to the supermarket, or who will give you a mask when you need to visit the hospital, or who will offer respirators for saving lives, and so forth. There are also solidarities among medical communities that share information towards the development of vaccines. Gilbert Simondon distinguished between abstract and concrete through technical objects: abstract technical objects are mobile and detachable, like those embraced by the eighteenth-century encyclopedists that (to this day) inspire optimism about the possibility of progress; concrete technical objects are those that are grounded (perhaps literally) in both the human and natural worlds, acting as a mediator between the two. A cybernetic machine is more concrete than a mechanical clock, which is more concrete than a simple tool. Can we thus conceive of a concrete solidarity that circumvents the impasse of an immunology based in nation-states and abstract solidarity? Can we consider the infosphere to be an opportunity pointing towards such immunology?

We may need to enlarge the concept of the infosphere in two ways. First of all, the building of infospheres could be understood as an attempt to construct techno-diversity, to dismantle the mono-technological culture from within and escape its bad infinity. This diversification of technologies also implies a diversification of ways of life, forms of coexistence, economies, and so forth, since technology, insofar as it is cosmotechnics, embeds different relations with nonhumans and the larger cosmos.16 This techno-diversification does not imply an ethical framework imposed onto technology, for this always arrives too late and is often made to be violated. Without changing our technologies and our attitudes, we will only preserve biodiversity as an exceptional case without ensuring its sustainability. In other words, without techno-diversity, we cannot maintain biodiversity. The coronavirus is not natures revenge but the result of a mono-technological culture in which technology itself simultaneously loses its own ground and desires to become the ground of everything else. The mono-technologism we live now ignores the necessity of coexistence and continues to see the earth merely as a standing reserve. With the vicious competition it sustains, it will only continue to produce more catastrophes. According to this view, after the exhaustion and devastation of spaceship earth, we may only embark on the same exhaustion and devastation on spaceship Mars.

Secondly, the infosphere can be considered a concrete solidarity extending beyond borders, as an immunology that no longer takes as its point of departure the nation-state, with its international organizations that are effectively puppets of global powers. For such concrete solidarity to emerge, we need a techno-diversity which develops alternative technologies such as new social networks, collaborative tools, and infrastructures of digital institutions that will form the basis for global collaboration. Digital media already has a long social history, though few forms beyond that of Silicon Valley (and WeChat in China) assume a global scale. This is largely due to an inherited philosophical traditionwith its oppositions between nature and technology, and between culture and technologythat fails to see a plurality of technologies as realizable. Technophilia and technophobia become the symptoms of mono-technological culture. We are familiar with the development of hacker culture, free software, and open-source communities over the past few decades, yet the focus has been on developing alternatives to hegemonic technologies instead of building alternative modes of access, collaboration, and more importantly, epistemology.

The coronavirus incident will consequently accelerate processes of digitalization and subsumption by the data economy, since it has been the most effective tool available to counter the spread, as we have already seen in the recent turn in favor of using mobile data for tracing the outbreak in countries that otherwise cherish privacy. We may want to pause and ask whether this accelerating digitalization process can be taken as an opportunity, a kairos that underlines the current global crisis. The calls for a global response have put everyone in the same boat, and the goal of resuming normal life is not an adequate response. The coronavirus outbreak marks the first time in more than twenty years that online teaching has come to be offered by all university departments. There have been many reasons for the resistance to digital teaching, but most are minor and sometimes irrational (institutes dedicated to digital cultures may still find physical presence to be important for human resource management). Online teaching will not completely replace physical presence, but it does radically open up access to knowledge and return us to the question of education at a time when many universities are being defunded. Will the suspension of normal life by coronavirus allow us to change these habits? For example, can we take the coming months (and maybe years), when most universities in the world will use online teaching, as a chance to create serious digital institutions at an unprecedented scale? A global immunology demands such radical reconfigurations.

This essays opening quote is from Nietzsches incomplete Philosophy in the Tragic Age of the Greeks, written around 1873. Instead of alluding to his own exclusion from the discipline of philosophy, Nietzsche identified cultural reform with philosophers in ancient Greece who wanted to reconcile science and myth, rationality and passion. We are no longer in the tragic age, but in a time of catastrophes when neither tragist nor Daoist thinking alone can provide an escape. In view of the sickness of global culture, we have an urgent need for reforms driven by new thinking and new frameworks that will allow us to unbind ourselves from what philosophy has imposed and ignored. The coronavirus will destroy many institutions already threatened by digital technologies. It will also necessitate increasing surveillance and other immunological measures against the virus, as well as against terrorism and threats to national security. It is also a moment in which we will need stronger concrete, digital solidarities. A digital solidarity is not a call to use more Facebook, Twitter, or WeChat, but to get out of the vicious competition of mono-technological culture, to produce a techno-diversity through alternative technologies and their corresponding forms of life and ways of dwelling on the planet and in the cosmos. In our post-metaphysical world we may not need any metaphysical pandemics. We may not need a virus-oriented ontology either. What we really need is a concrete solidarity that allows differences and divergences before the falling of dusk.

I would like to thank Brian Kuan Wood and Pieter Lemmens for their comments and editorial suggestions on the drafts of the essay.

Yuk Hui currently teaches at the School of Creative Media, City University of Hong Kong, his latest book is Recursivity and Contingency (2019).

2020 e-flux and the author

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One Hundred Years of Crisis - Journal #108 April 2020 - E-Flux

Trinity to set up Covid-19 research centre – The Irish Times

Trinity College Dublin is to set up a Covid-19 research hub that will focus on the most urgent scientific breakthroughs needed to address the current pandemic including design of new drugs and a vaccine to combat the virus.

The hub will work with doctors from St Jamess Hospital, Dublin, other hospitals in Ireland, and established research partners around the world.

It will also work on development of rapid antibody testing capacity to identify current and previous Covid-19 infection in healthcare workers, and eventually the wider community.

This will be critical to determining if doctors and nurses can return to frontline services after infection by the virus, and to informing any easing of lockdown restrictions in the general population.

The problem of supply and validation of commercial antibody testing kits will also be on its research agenda, as numerous test kits coming on to global markets are proving to be inaccurate.

Prof Kingston Mills, who is co-leading the project, underlined the importance of investigating the immune response in infected and recovered Covid-19 patients to establish whether previous infection prevents reinfection, including serial sampling of patients at St Jamess Hospital and other collaborating hospitals.

The Covid-19 Research Hub will be located at Trinitys biomedical sciences institute, and led by immunologists there and infectious disease clinicians from St Jamess Hospital.

As foundation partner, AIB has committed 2.4 million to advance the project while the hub will continue to accept contributions from other public and private sources.

Prof Mills said the research would concentrate on the immune responses to the virus in infected and recovered patients. This will provide key information for the design of vaccines and immunotherapeutic drugs for controlling the often fatal inflammation in Covid-19 patients, and will assist in developing and validating new assays for detecting antibody responses to the virus, thereby identifying those who are immune and therefore safe to return to work.

According to AIB chief executive Colin Hunt: In the face of this unprecedented medical, societal and economic crisis, it is imperative that we mobilise all the resources at our disposal in a strategic way. We are investing in a national and international endeavour to save lives. Trinity ranks in the top 1 per cent of research institutions globally in medicine and biological sciences, and its immunologists collaborate with the best internationally.

The initiative will also involve the expertise of leading immunologist Prof Luke ONeill.

TCD provost Patrick Prendergast said the solution to the Covid-19 crisis would probably be found in university laboratories in the months ahead following collaboration between leading researchers across the globe.

Trinity is one of the worlds leading universities when it comes to research into immunology and immunity and has the research expertise to play a major role. Donations such as this are a generous, practical and timely contribution to the fight against this terrible virus, he said.

Prof Aideen Long, director of Trinitys translational medicine institute, is the other co-leader, while consultant immunologist Niall Conlon; consultant physician in infectious diseases Colm Bergin; professor of translational immunology Padraic Fallon; and consultant Clona N Cheallaigh will all play key roles.

The project will also benefit from Trinitys global network of collaborations and contacts in universities such as MIT in Boston and Utrecht University in the Netherlands, and with Public Health England, so knowledge is shared and breakthroughs on Covid-19 are as effective and swift as possible.

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Trinity to set up Covid-19 research centre - The Irish Times

James Allison, chair of Immunology and executive director of the Immunotherapy Platform at MD Anderson Cancer Center – InnovationMap

The city of Houston much like most major cities in the country is in crisis mode, with a stay-at-home mandate and rising COVID-19 case numbers.

But these three Houston innovators are emerging as leaders in making masks, discussing the importance of telemedicine at this time, and providing tips on keeping a stable supply chain.

Photo courtesy of Accel Lifestyle

Former scientist Megan Eddings designed a fabric that doesn't hold onto bacteria, and she's launched an activewear brand of men's and women's T-shirts that don't stink. But when the coronavirus hit the country and medical professionals worried about personal protection equipment, Eddings sprung into action.

"We have enough supplies here to make 9,000 masks and I have 2,800 yards of fabric sitting at my factory in California," she says. "That's enough fabric to make more than 100,000 masks." Click here to read more about Houston fashion designers looking to help out.

Photo courtesy of TMCx

Telemedicine has a unique opportunity during the coronavirus-cased shutdown. Lance Black, associate director of the Texas Medical Center's accelerator, TMCx, joined the Houston Innovators Podcast to discuss the health tech potential as well as how startups are coping in this uncertain time.

"This is going to force the health care system to take a hard look at what these platforms are capable of doing," Black says in the episode. "And it's going to stress the capabilities of these companies. To be honest, if there's a silver lining, that is one of them in my mind, that this will prove out the technology [in telehealth.]" Click here to read more and stream the episode.

Photo courtesy of Smith and Associates

The COVID-19 outbreak has already greatly affected supply chains across industries, and companies should keep moving forward with that in mind. Todd Burke, president at Houston-based Smith and Associates gives three tips for properly managing your supply chain during the coronavirus outbreak in a guest article.

"During my 23 years at Smith, the world's largest open-market distributor of electronic components, I've witnessed various market disruptions and shifting supply chain dynamics," writes Burke. "I can confidently say that the coronavirus outbreak is heavily uncharted territory for the technology industry." Click here to read more.

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James Allison, chair of Immunology and executive director of the Immunotherapy Platform at MD Anderson Cancer Center - InnovationMap