Category Archives: Human Behavior

NIH investigators hope CD47 study leads to broad-spectrum infectious diseases immunotherapy – National Institutes of Health

News Release

Tuesday, June 23, 2020

National Institutes of Health investigators and colleagues have discovered that when the immune system first responds to infectious agents such as viruses or bacteria, a natural brake on the response prevents overactivation. Their new study in mBio describes this brake and the way pathogens such as SARS-CoV-2, the virus that causes COVID-19, turn it on. Their finding provides a potential target for an immunotherapy that might be applied to a wide range of infectious diseases.

When a cell senses an infectious agent with molecules called pathogen recognition receptors, part of its response is to increase cell surface expression of a molecule called CD47, otherwise known as the dont eat me signal. Increased CD47 expression dampens the ability of cells called macrophages, the immune systems first responders, to engulf infected cells and further stimulate the immune response. Upregulation of CD47 on cells was observed for diverse types of infections including those caused by mouse retroviruses, lymphocytic choriomeningitis virus, LaCrosse virus, SARS CoV-2, and by the bacteria Borrelia burgdorferi and Salmonella enterica typhi.

By blocking CD47-mediated signaling with antibodies in mice infected with lymphocytic choriomeningitis virus, the authors demonstrated they could enhance the speed of pathogen clearance. Furthermore, knocking out the CD47 gene in mice improved their ability to control M. tuberculosis infections and significantly prolonged their survival. In addition, retrospective studies of cells and plasma from people infected with hepatitis C virus indicated that humans also upregulate CD47. In these studies, inflammatory cytokine stimuli and direct infection both promoted increased CD47 expression.

This highly collaborative research project involved 14 different institutions and was led by scientists from NIHs National Institute of Allergy and Infectious Diseases in Hamilton, Montana, and Stanford University in Stanford, California. The findings open the possibility of using CD47 blockade as a new immunotherapeutic to treat a wide range of different infections. There may be circumstances where host responses need boosting and CD47 represents a novel target for host-directed therapies in such cases, the scientists write, mentioning SARS-CoV-2, HIV, HPV and Ebola virus among several possibilities.

M Caspi Tal et al. Upregulation of CD47 is a host checkpoint response to pathogen recognition. mBio DOI: 10.1128/mBio.01293-20 (2020).

Kim J. Hasenkrug, Ph.D., Chief of NIAIDs Retroviral Immunology Section, is available for comment.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.

NIAID conducts and supports research at NIH, throughout the United States, and worldwide to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

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NIH investigators hope CD47 study leads to broad-spectrum infectious diseases immunotherapy - National Institutes of Health

Is A Second Wave Of Coronavirus Coming? – Kaiser Health News

This story was produced in partnership with PolitiFact.

As Americans continue to grapple with the novel coronavirus, one question is on a lot of peoples minds: Are we already seeing, or will we eventually see, a second wave of the virus?

On June 16, Vice President Mike Pence penned anop-ed in The Wall Street Journal headlined, There Isnt a Coronavirus Second Wave, where he said the country was better off than media reports suggested.

Yet the same day, in aninterview with the same newspaper, Dr. Anthony Fauci, the top federal infectious disease expert, threw cold water on Pences assertion by warning of a possible resurgence. People keep talking about a second wave, he said. Were still in a first wave.

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Defining a coronavirus wave is somewhat more art than science, but other scientists looking at the number of new daily infections echo Faucis caution.

The number of new daily infections (as seen in this chart) declined by only about one-third between its peak in early March and its most recent low point in early June. And since early June, the data shows an upward spike, approaching where it stood at that peak.

We checked with experts to better understand what wave were currently in, what the outlook is for a possible new wave, and what, if anything, we can learn from the history of the 1918 influenza pandemic, which was the last major pandemic in the United States. Heres what we found.

Are We Out Of The First Wave Yet?

Theres no official definition of when a wave begins or ends but, generally speaking, it requires a peak in infections followed by a substantial reduction. A new rise and peak would signal the start of another wave.

It is probably not realistic for the number of new cases to drop to zero, but ideally one would like to see sustained decreases in the number of new cases over time or stability in the number of new cases over time, said Nicole Gatto, an associate professor in the School of Community and Global Health at Claremont Graduate University in California.

The chart above, showing the national picture, suggests there was an easing in the number of new cases, but not a large drop prior to the current spike, scientists say.And certain states have not come close to finishing their first wave.

Some places, such as New York and Boston, have what appears to be a clear first peak or wave, said Brooke Nichols, an assistant professor at Boston Universitys School of Public Health. Some places are still in the first wave.

The following chart shows states that have experienced a first wave and substantially brought down their new infections.

Meanwhile, other states havent yet turned the corner on the first wave:

If youre in a state that is still seeing an increase in cases, it would not be accurate to talk about a second wave, Gatto said. What causes those peaks, and whether or not there will be more than one peak, as opposed to one continuous wave, will be human behavior and how humans react to what is going on around them.

Were There Multiple Waves During The 1918 Influenza Epidemic?

There were at least three distinct waves of influenza in1918 and 1919, which killed an estimated 50 million people worldwide. The pandemic was simultaneous with World War I, and the war is believed to have spread the virus around the globe more quickly than it otherwise would have.

The first wave began in March 1918 and eased by the summer. The second wave came in the fall, followed by a third wave during the winter and spring of 1919. Heres a rough graphic from anacademic papershowing the waves in deaths:

The first wave was not very deadly, said J. Alexander Navarro, assistant director of the Center for the History of Medicine at the University of Michigan. It was about as bad as ordinary strains of seasonal influenza that had been circulating up until that point.

The second wave was the deadliest, and that may have been due to mutations that increased the viruss lethality, although scientists say this is speculative and that such mutations more typically take much longer to develop and spread.

The second wave slowed towards the end of November, in part because more stringent social distancing measures were put in place, said Kenneth Davis, author of More Deadly Than War: The Hidden History of the Spanish Flu and the First World War. When those were relaxed, a third wave commenced in the winter and spring of 1919.

The third wave lasted into early March, and some suggest there was a fourth wave during the winter of 1920. Each was less deadly than the one before it, Navarro said, although there were regional differences in severity.

The decline in lethality after the second wave was probably shaped in part by the declining number of people who hadnt already been infected, Navarro said. When infections in a population become sufficiently widespread, that can slow the further spread due to herd immunity.

How Much Can The 1918 Pandemic Tell Us About What To Expect Now?

While both pandemicsinvolved an easily transmissible respiratory disease, there are some important differences that make the 1918 pandemic less helpful in predicting the course of the novel coronavirus.

One is that the 1918 outbreak involved influenza, which is caused by a different family of viruses than the coronavirus. This brings both good and bad news.

On the positive side, the coronavirus appears to be much more stable than the influenza virus, and thus less likely to mutate into a more deadly variant, said Ravina Kullar, an infectious disease specialist and adjunct faculty member at UCLA. The coronaviruss spike protein, which enables it to attach to human cells and attack them, appears to be especially resistant to mutation.

On the downside, the coronavirus doesnt seem to have a significant seasonal aspect. Influenza worsens as the weather gets colder but eases up during the warmer months. While we may have seen a reduction in coronavirus infections in recent weeks because more human interactions are moving outdoors, scientists dont expect the same scale of seasonal drop-off for the coronavirus.

What were seeing right now is that its not impacted by the climate, Kullar said. Warm and humid places like Mumbai and Indonesia have struggled with the virus, and in the United States, cases are rising in hot states like Arizona and Florida.

The patterns in mutations and seasonality suggest that the coronavirus may not follow the wave patterns of the 1918 flu. Instead, the spread of the coronavirus may follow something more like a plateau, with spikes possible if social distancing isnt adhered to fully.

There are other differences between now and 1918.

On the upside, we now know much more about viruses and public health, and science is able to devise targeted treatments and vaccines.

On the other hand, the worlds population is bigger and more densely packed. In 1918, the worlds population was smaller than 2 billion, while today itsabout 7.6 billion. Today, we also have commercial aviation, which can carry infected people around the world far faster than trains and ships could in 1918.

A bigger, denser, more mobile population means a greater chance for a virus to continue spreading.

In 1918, some cities saw an easing of the pandemic once they neared herd immunity, but thats not going to be as helpful with the coronavirus. Because the coronavirus is more infectious than the 1918 virus, the percentage of the population needed to reach herd immunity has to be about 65% today, compared with about 35% in 1918.

In 1918, they could get through the pandemic more quickly because of that, and even so, they did it with a staggering death toll, Navarro said. Today, the coronavirus will be with us for a lot longer.

What Factors Could Cause A New Wave?

The biggest risk, scientists say, is a loosening of social distancing measures.A much larger portion of the economy todayis engagedin consumer-driven commerce such as the restaurant and entertainment sector. This heightens the economic pressure to relax social distancing standards. But doing so could worsen the pandemic.

In 1918, once measures were lifted, the population very quickly went back to life as normal, flocking to movies, shops and stores, dance halls and saloons, Navarro said. That led to another spike of cases in many cities.

Nichols said a communitys past experience with the virus can make a difference.In Boston, where Nichols is based, the first wave was relatively severe, and many people know someone who was personally affected by COVID or had a COVID-related death in the family, she said. That affects peoples behavior. In areas where epidemic growth has been slow, the urgency of changing ones behavior is less.

Nichols added that experiencing the summer, when people have the freedom to interact outdoors, could make it harder to practice social distancing in the colder months.

I fear that people will continue their summer socializing patterns into the fall and winter, turning very low-risk interactions into relatively high-risk interactions, she said.

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Is A Second Wave Of Coronavirus Coming? - Kaiser Health News

After Months Spent Inside, The Great Indoors Is Uncannily Relevant – Vulture

I am unapologetically indoorsy. Photo: FORTEPAN/LENCSE ZOLTN

What are the effects of spending an entire season indoors, as most of us have done this year? I dont mean the psychological effects but the material ones. I wonder about the carpets that have gotten worn down from pacing. The couches that sag from cradling our butts all day. The expanded inventories of elastic-waist pants, house slippers, sweatshirts. Among other lessons learned, weve had a chance to become intensely familiar with what we like and dislike about our living spaces. Weve experienced every day what studies have confirmed: Plants, space, and sunlight make people happy, while extreme temperatures, loud noise, cramped conditions, and dim light make people unhappy. The pandemic has forced us to confront exactly how little control we have over our homes.

Thats the subject of Emily Anthess The Great Indoors: The Surprising Science of How Buildings Shape Our Behavior, Health, and Happiness. Along with domestic spaces, Anthes explores a range of buildings fancy offices, operating rooms, a housing development designed for adults with autism, a solitary-confinement unit in hopes of dissecting the effects of architecture and design on human behavior. I read it, in a perverse spirit, entirely outside, on a sunny patch of grass, without a single person within seeing or hearing distance. I am unapologetically indoorsy, writes the author in her introduction. Its not that I dont like nature; I think nature is lovely. Ive been camping several times and enjoyed it! Ha. Me and Emily Anthes, we could not be less alike.

The formula for popular social-science books is: cold open on a catchy anecdote, proceed to divulge personal interest in topic, pivot to argument about why topic is universal and not remotely what the reader expected, and then spend 240 pages on scenes of varying persuasiveness. Im usually out by page 30. I dont know if this is a fault of my attention span, the formula, the kind of author who is drawn to the formula, or constraints pushed by publishers eager to get the book on a best-seller list. In any case, my alarm bells tend to go off early.

In order to enjoy one of these books, you need to trust the authors ability to responsibly synthesize specialized knowledge that lies outside of her, and your, expertise. You need to know in your soul that the author is not the type of person to cite Wikipedia as a source or become enveloped in a plagiarism scandal one instant after you finish reading her book. I am glad to report that Anthes passes the trustworthy test. Her sources are respectable and diligently noted. My margins were covered with scribbled WTFs not because she was drawing deranged conclusions from misinterpreted studies but because the book contains piles of cool facts that are actually, from what I can tell, facts.

Those cool facts come fast and furious. The New York City subway, for example, is smothered in microbes associated with bare feet. Why? Anthes quotes a microbiologist on the topic: Every time you take a step, your heel comes up and then presses down, creating a small bellows of bottom-of-your-foot air squirting out into the surroundings. The scientist continues: Imagine millions of people running around down there. Puff puff puff puff puff every time they take a step, they put out a little puff of foot microbiology. Another WTF moment: Pillowcases and toilet-seat surfaces are apparently strikingly similar from a microbiological perspective. These are from a chapter on the billions of invisible roommates we cohabit with, from bacteria to fungi to dust motes to a zoos worth of wee invertebrates. In one scene, Anthes unscrews her showerhead and swabs the interior, then mails it off to a lab. The results come back a year later. Among other things, her showerhead contains an organism called RB41, which has been found in dog noses and paleolithic cave paintings, and a class of mycobacteria that can cause tuberculosis and leprosy when inhaled. Nothing to freak out about, the scientist who processed the swabs assures Anthes. Many of those could be totally nonpathogenic. Could be!Even the least germophobic reader will squirm at the descriptions of carpeting (disgusting a scientists term, not mine!) and basements (hotbeds of arthropod diversity). However, its less boring to stay home all day when you know that your house is a teeming jungle.

Hospitals are scarier. Design can alter patient outcomes in unnerving ways, suggesting that our fragile bodies are susceptible to environmental factors not just psychologically but on some mysterious mechanical level. Surgical patients with plants in their rooms have lower blood pressure and use less pain medication than patients in plant-free rooms. Patients in sunny rooms fare better than patients in shady rooms. In one study, patients treated in rooms with sound-absorbing tiles were significantly less likely to be readmitted within three months. When Florence Nightingale recommended sunlight and flowers for the infirm in 1859, she anticipated what would later become known as evidence-based design.

The books best chapter explores how neuroatypical people interact with their surroundings. Gallaudet University is a private college in Washington, D.C., that largely serves students who are deaf or hard of hearing. A group of academics and architects at the school outlined design features tuned to the needs of the students, including translucent and partial walls and rooms painted in soft blues and greens, which contrast with human-skin tones and make it easier to perceive gestures. Designers who worked on a housing development created for adults with autism made a slew of decisions that would probably appeal to people without autism too, pouring a layer of gypsum concrete between each floor to dampen the sound of footfall and cleverly installing shower temperature knobs opposite the showerhead, so residents didnt have to dart through a stream of frigid or boiling water in order to adjust it. (Can we standardize that?) In a 2015 study, researchers created a dental office designed to soothe children with autism, featuring dimmer lights, relaxing music, and calming images projected onto the ceiling. What happened next will not shock you: The changes were received warmly by neurotypical people, too.

A good chunk of the books material fits into the obvious category, but its always nice to see ones personal preferences ratified by data. A study of IT employees confirmed that face-to-face communication as opposed to, say, Slack was correlated with higher productivity and performance. (I believe workers required to use Slack should be paid extra for the sheer attentional burden of it.) Students who attend class in well-ventilated and well-maintained buildings perform better academically. A detention facility remodeled to include athletic facilities, a library, and classrooms saw the number of assaults drop by 50 percent.

But for every unsurprising conclusion, theres a curveball. Anthes visits a Louisiana professor who has developed a buoyant foundation that allows houses to float on top of floodwaters. The system requires no heavy equipment and can be installed inexpensively on an existing house by just two people. Rather than pour catastrophically into a home, the floodwater itself lifts residents to safety. But what would seem like a brilliant answer to Hurricane Katrina (and a future of similar disasters, worsened by climate change) is stymied by the federal government. Homeowners in high-risk areas are required to buy flood insurance, but amphibious structures like the floating foundations are not eligible for subsidized policies. When Anthes reaches out to FEMA, shes told that the technology is not as safe as simply moving to a higher elevation. Well, sure.

The Great Indoors isnt a self-help book, but our present context has layered it with some self-helpy applications. You cant necessarily drill a window into your wall or blast a skylight into your ceiling, but you can push your favorite chair closer to the window and find out whether being depressed in a pool of sunlight is better than being depressed in a veil of shadows. If you cant turn your bedroom into an anti-sensory cocoon, do it to your own body with a pair of earplugs and an eye mask. Pick a clump of roadside greenery next time you go outside (in your mask) and put it in a rinsed-out jar on the kitchen table. All those studies proving that plants cause joy? They dont specify that the plants should be exquisite. Gather ye weeds while ye may.

*A version of this article appears in the June 22, 2020, issue ofNew York Magazine. Subscribe Now!

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After Months Spent Inside, The Great Indoors Is Uncannily Relevant - Vulture

How to Scare Away Wild Coyotoes Courtesy of the Overheard at National Geographic Podcast – LaughingPlace.com

by Alex Reif | Jun 23, 2020 5:34 PM Pacific Time

New co-host Amy Briggs made her debut in todays episode of the Overheard at National Geographicpodcast, the second episode of season three titled The Unstoppable Wily Coyote.She joins host Peter Gwin for an exploration of a species that is thriving like never before as the natural world is further developed.

One of this episodes three special guests is Chrsitine DellAmore, an editor at National Geographicwhos been tracking this story in major cities like Chicago where a coyote being tracked with a collar was attracted to a noisy construction site. Another guest is Mary Ann Bonnell, a Natural Resources Specialist in Denver, Colorado, who has seen a huge increase in coyote encounters since first seeing one in the 1990s.

In 2004, Denver received just two reports of Coyotes in the area. By 2009, the number had increased into the thousands with reports of attacks against pets such as dogs and cats. Mary Ann Bonnell is personally trying to change human behavior in the area, teaching residents how to safely scare a Coyote to get them to back up at least ten feet. The technique is called hazing, which involves lunging towards the animal a few steps while yelling to startle them back.

Zoologist Roland Kays offers insight into how the coyote became such an incredible mesopredator with some insight into how they lived during the ice age. As humans have torn down forests, bigger predators that would usually hunt coyotes are no longer around to keep their population in check, leading to a rise in their numbers.

One of the concerns for the future is coyotes migrating to South America and becoming an invasive predator for their local endangered species. The conversation with all three guests talks about what humans need to do to fix the problem long term because as listeners will hear, theres not a single simple solution.

You can listen to this unique conservation story and read a transcript on the official website for the Overheard at National Geographicpodcast.

Alex has been blogging about Disney films since 2009 after a lifetime of fandom. He joined the Laughing Place team in 2014 and covers films across all of Disneys brands, including Star Wars, Marvel, and Fox, in addition to books, music, toys, consumer products, and food. You can hear his voice as a member of the Laughing Place Podcast and his face can be seen on Laughing Places YouTube channel where he unboxes stuff.

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How to Scare Away Wild Coyotoes Courtesy of the Overheard at National Geographic Podcast - LaughingPlace.com

What poker plays can teach us about decision-making : The Indicator from Planet Money – NPR

Lionel Bonaventure/AFP via Getty Images

Lionel Bonaventure/AFP via Getty Images

Psychologist and journalist Maria Konnikova decided to learn how to play high stakes poker, as a way to study human behavior. She got a lot more than she bargained for. She learned how to play, and how to win. She also learned about the gender imbalance in the world of competitive poker, and how women are consistently underestimated by men. She learned about how players manage risk, and that poker is every bit as skilled a profession as investing. And maybe even more so.

Check out Maria Konnikova's new book, The Biggest Bluff:

https://www.penguinrandomhouse.com/books/562852/the-biggest-bluff-by-maria-konnikova/

Music by Drop Electric. Find us: Twitter / Facebook / Newsletter.

Subscribe to our show on Apple Podcasts, PocketCasts and NPR One.

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What poker plays can teach us about decision-making : The Indicator from Planet Money - NPR

Human Impact on Wildlife Revealed by COVID-19 Lockdown – SciTechDaily

Movebank data worldmap. Credit: MPIAB/ MaxCine

An international team of scientists is investigating how animals are responding to reduced levels of human activity during the Covid-19 pandemic.

In an article published in Nature Ecology & Evolution on June 22, 2020, the leaders of a new global initiative explain how research during this devastating health crisis can inspire innovative strategies for sharing space on this increasingly crowded planet, with benefits for both wildlife and humans.

Many countries around the world went into lockdown to control the spread of Covid-19. Brought about by the most tragic circumstances, this period of unusually reduced human mobility, which the articles authors coined anthropause, can provide invaluable insights into humanwildlife interactions.

There have been countless posts on social media over the past few months reporting unusual wildlife encounters. Anecdotal observations, especially from metropolitan areas, suggest that nature has responded to lockdown. There not only seem to be more animals than usual, but there are also some surprising visitors: pumas have been spotted prowling the streets of downtown Santiago, Chile, and dolphins recently showed up in untypically calm waters in the harbor of Trieste, Italy.

Mallard with solar GPS tag. Credit: Sergio Izquierdo

For other species, the pandemic may have created new challenges. For example, some urban-dwelling animals, like gulls, rats or monkeys, may struggle to make ends meet without access to human food. In more remote areas, reduced human presence may potentially put endangered species, such as rhinos or raptors, at increased risk of poaching or persecution. The authors emphasise that societys priority must be to tackle the immense human tragedy and hardship caused by Covid-19. But, they argue that we cannot afford to miss the opportunity to chart, for the first time on a truly global scale, the extent to which modern human mobility affects wildlife.

To address this challenge, researchers recently formed the COVID-19 Bio-Logging Initiative. This international consortium will investigate animals movements, behavior and stress levels, before, during and after Covid-19 lockdown, using data collected with nifty animal-attached electronic devices called bio-loggers. The articles lead author, Christian Rutz, a biologist at the University of St Andrews, UK, and President of the International Bio-Logging Society, explains: All over the world, field biologists have fitted animals with miniature tracking devices. These bio-loggers provide a goldmine of information on animal movement and behavior, which we can now tap to improve our understanding of humanwildlife interactions, with benefits for all.

Cheetah with ear tag. Credit: Sergio Izquierdo

The team will integrate results from a wide variety of animals, including fish, birds, and mammals, in an attempt to build a global picture of lockdown effects. Francesca Cagnacci, Senior Researcher at the Edmund Mach Foundation in Trento, Italy, and Principal Investigator of the Euromammals research network, says: The international research community responded quickly to our recent call for collaboration, offering over 200 datasets for analysis. We are very grateful for this support.

So, what do the scientists hope to learn? Matthias-Claudio Loretto, a Marie Skodowska-Curie Fellow at the Max Planck Institute of Animal Behavior in Radolfzell, Germany, explains that it will be possible to address previously intractable questions: We will be able to investigate if the movements of animals in modern landscapes are predominantly affected by built structures, or by the presence of humans. That is a big deal. These insights will in turn inspire innovative proposals for improving humanwildlife coexistence, according to Martin Wikelski, Director of the Max Planck Institute for Animal Behavior in Radolfzell and Principal Investigator in the Cluster of Excellence Centre for the Advanced Study of Collective Behaviour at the University of Konstanz, Germany. Nobody is asking for humans to stay in permanent lockdown. But we may discover that relatively minor changes to our lifestyles and transport networks can potentially have significant benefits for both ecosystems and humans.

Coordinated global wildlife research during this period of crisis will provide unforeseen opportunities for humans to forge a mutually beneficial coexistence with other species, and to rediscover how important a healthy environment is for our own well-being.

Reference: COVID-19 lockdown allows researchers to quantify the effects of human activity on wildlife by Christian Rutz, Matthias-Claudio Loretto, Amanda E. Bates, Sarah C. Davidson, Carlos M. Duarte, Walter Jetz, Mark Johnson, Akiko Kato, Roland Kays, Thomas Mueller, Richard B. Primack, Yan Ropert-Coudert, Marlee A. Tucker, Martin Wikelski and Francesca Cagnacci, 22 June 2020, Nature Ecology & Evolution.DOI: 10.1038/s41559-020-1237-z

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Human Impact on Wildlife Revealed by COVID-19 Lockdown - SciTechDaily

‘Humans are not prepared to protect nature’ – DW (English)

Peter Sloterdijk describes change as the modern name for something that classical philosophy called becoming, because everything that is, is not given in stable, everlasting forms but has to become what it is. He says modernity is all about interfering with this process of becoming, and puttingit or pushing it into a direction that fits better with human purposes.

DW: So we are always changing then?

Peter Sloterdijk: Yes. Nature as such is a self-changing entity. And all we can do is as it were keep riding on the wave of change.

As we look to the future and that wave gets bigger and bigger with regard to the danger of climate change, there are some big changes that we have to make as a species. And it seems at the moment we're not able to make them. Why?

Human beings are not prepared to protect nature in any sense. Because in all our history as a species, our deepest conviction always was that we are the ones who have to be protected by the powers of nature. And we arenot really prepared for this inversion. Just as a baby cannot carry his or her mother, human beings are not prepared or not able to carry nature. They must learn to deal with this immensity. This is a huge challenge because there is no longer the classical excuse that we are too little or too small in order to deal with such immensities.

Not prepared, or not willing to protect nature?

Is it a narcissism that is preventing it? What is the problem?

I sense the problem is one of scale. We are almost physiologically unable to add up the results of our own behavior to cosmic consequences. We are deeply convinced that all we do could and should be forgiven. From an ecological point of view, we are living in a period of time of lost innocence.

Read more:Am I a narcissist?

Have I understood you correctly that on a planetary scale, we're all looking for a sense of forgiveness? That we want to purge ourselves of what we've done?

And there will be lots of sins to be forgiven. And the more we understand that the higher the likelihood thatone day we will develop patterns of behavior to cope with the new situation.

One of the questions we've been thinking about in this interview series is the idea of comparing the two crises. Our response to the pandemic was immediate, almost unbelievably fast and unified. And then our response to the climate crisis seems to be stymied or stalled. Is there any way to look at these two forms of crisis in a similar light?

What our response to the coronavirus is proving is that the globalization through media is an almost accomplished project. The world as a whole is more or less synchronized and pulls together into one hothouse for contagious news. The infection by information is as strong, even stronger, than the infection by the virus. And so we have two pandemics at the same time: one, a pandemic of fear, and the other of real contagion.

Coronavirus has dominated headlines for months

You say that modernity has stopped us from becoming who we are. Can we change who we are?

Yeah. So I do not think that we can change our DNA simply by changing our thoughts. But we can change the grammar of our behavior. And that is what the 21st century will teach to the global community

What does that mean to change the grammar of our being?

Not of our being, but behavior. The grammar of our behavior.

What is that?

Everything we do adheres to a structure similar to a language. And acting is something that is ruled by hidden structures, such as every sentence we produce is ruled by grammar and lexicon. And I think that we are still uneasy on the level of lexical change. So we are now learning new terms, a new vocabulary, but, by and by, we shall also learn a new grammar.

Read more:Disinformation and propaganda during the coronavirus pandemic

So we're in the process of putting the building blocks of language together. Do you think we'll be able to speak before the destruction written on the wall comes true?

What I have found especially impressive in the behavior of the masses during this crisis is the incredible docility with which vast parts of the population in the West as in the East were ready to obey the new rules of precaution and distance. These are already new elements of a different social grammar.

Read more:Rutger Bregman: 'The virus is contagious, and so is our behavior'

But that can also be quite scary, right? That we in a matter of weeks were able to give up very basic freedoms

Oh yes. At the same time, it shows that we must not underestimate the plasticity of the human element. But who knows how long this patient behavior will last. I think we should continue our reflections in one year or so. I would be surprised if you are not a little bit more intelligent.

According to Sloterdijk, we are already witnessing elements of a new social grammar

Thinking about the human element, has our response to the coronavirus something none of us has really encountered beforechanged your outlook on humanity in any way?

Yes and no. Certainly, I'm as surprised as many contemporaries are. But at the same time, it also confirms something I have been developing for decades on a theoretical level. What I mean is that it confirms my assumption that the human race has reached a situation of synchronicity on the basis of a stream of information. We really are globally connected and are living more and more in the same time dimension. There's something like the eternal presence of globalization, and this has been an important feature of this crisis. Everything happens more or less at the same time. And the only differences we see are delays between different foci of events. But, on the whole, there is one big chain of events and connectedness.

Read more:'The time has come for humanity to go through its next evolution'

On a personal level, Peter, can you remember the last time you felt a change within yourself?

Yeah, I experienced a deep change in my existential mood at the age of about 33. I went to India and spent approximately four months there. That was a disruptive event in my own life. But the most similar event and the most comparable to now, even if it sounds quite unlikely, were those sublime days when the Berlin Wall fell down. For a span of time of approximately two months, I was not able to hear or see anything else but news from the political front.

And this was the sublime as it were music of reunification. And when that was over, I understood that it was over only when I was able to watch an ordinary movie for the first time afterwards. And right now I am still waiting for the moment when I will be able to listen to the music and to watch movies as I could before.

Peter Sloterdijk is one of Germany's most influential thinkers.Over the course of his career, he has published dozens of books that run the gamut of philosophical inquiry.Now retired from university instruction, he regularly contributes to public debate through interviews published in leading periodicals around Europe, among them Germany's Die Zeit, Spain's El Pais, and France's Le Point.

France hit record temperatures this summer, and the urban heat island effect means cities are particularly hot. While vegetation releases water into the atmosphere, cooling things down, concrete and asphalt trap heat. During a heat wave, Paris can be 10 degrees hotter than the surrounding countryside. Pollution also builds up in slow-moving summer air another reason urban heat waves can kill.

In August 2005, Hurricane Katrina tore apart one of America's most iconic cultural heartlands. Even though it's rebuilt, New Orleans has been battered again and again by powerful storms. A government report last year said the US southeast was "exceptionally vulnerable to sea-level rise, extreme heat events, hurricanes and decreased water availability." Trump's response? "I dont believe it."

This year India's monsoon was the second driest in 65 years, leaving 44% of the country suffering from drought. In Chennai, things have become desperate: its main reservoir has dried up, residents are queuing for hours at pumps, water is being trucked in and hospitals are under pressure. As the planet heats up, more and more cities could run out of water.

Arctic temperatures are rising faster than anywhere else on Earth. This is taking its toll on cities in Russia's far north, as the permafrost beneath building foundations begins to melt. Cities like Norilsk and Yakutsk are already seeing serious subsidence, and scientists expect their infrastructure to become at least 25% less stable by mid-century.

Rising seas threaten coastal cities the world over, but Jakarta, with 13 rivers, suffers more floods than most. Limited access to water means residents pump it from underground aquifers, causing subsidence. By 2050, 95% of North Jakarta could be submerged. Indonesia is building the world's biggest seawall to protect its capital, but that could leave thousands of fishermen without homes or income.

Some 28% of the population of Bangladesh lives on the coast, and high tides are rising 10 times faster than the global average. In 2018, natural disasters displaced 78,000 people, with riverbank erosion expected to increase as Himalayan ice melts moving many more. Already one of the world's most densely populated cities, the capital of Dhaka takes in 1,000 new migrants every day.

Author: Ruby Russell

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'Humans are not prepared to protect nature' - DW (English)

‘Social Unrest: Resolving The Dichotomies Of Me/You And Us/Them’ On Monday’s Access Utah – Utah Public Radio

Monday's Access Utah episode.

Derrik Tollefson is Professor of Social Work and head of the Department of Sociology, Social Work and Anthropology at Utah State University. He also directs the I-System Institute for Transdisciplinary Studies at USU.

The I-System Model, which provides the foundation for both Mind-Body Bridging and Productive Mind, was developed by Stanley H. Block, MD, together with his wife, Carolyn Bryant Block in the late 1990s to optimize heath, wellness, and human performance. The I-System Model presents a view of individual and collective psychosocial human functioning and embraces a holistic approach to healing and wellness.

Derrik Tollefson is a co-author, with Stanley Bock, Carolyn Bryant Block and Guy du Plessis, of Social Unrest: Resolving the Dichotomies of Me/You and Us/Them: The I-System Model of Human Behavior.

This episode is a part of UPRs Project Resilience made possible with support from the USU Center for Persons with Disabilities and The Family Place in Logan.

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'Social Unrest: Resolving The Dichotomies Of Me/You And Us/Them' On Monday's Access Utah - Utah Public Radio

‘The Biggest Bluff’ is the nuts – Sports – Maine Edge

Play the man, not the cards. Its an adage that has been circulating in the poker world since there has been a poker world in which it could circulate. But how true is it?

Thats one of the fundamental questions explored in Maria Konnikovas new book The Biggest Bluff: How I Learned to Pay Attention, Master Myself, and Win (Penguin Press, $28). Konnikova is the perfect person to explore such a question, combining a longtime study of psychology and human behavior and a complete lack of knowledge regarding poker. Through answering that question, she sought to get a firmer grasp on the role of chance in the way our worlds operate.

She gained that understanding, to be sure, but that was far from all.

The pitch was simple go from utter neophyte to the World Series of Poker in one year. But while she achieved her goal, Konnikova also wound up completely changing the trajectory of her life, both personally and professionally. Her voyage through the poker world opened her eyes to a number of truths about herself and her perceptions and proclivities.

It also turned her into a hell of a player. A good player and a surprisingly successful one.

Maria Konnikovas idea came from a run of bad luck in her life; that stretch made her question just how much of an impact chance has on our lives. She wanted to learn what she could control and what she could not. But how to judge such a thing? The eureka moment came via the work of legendary game theorist John von Neumann, who viewed poker as perhaps the most elegant and effective real-world example of something striking the balance between skill and luck. The only problem? She didnt know how to play.

Thats where Eric Seidel came in.

Seidel is one of the legends of poker, someone who has been among the best player in the world for decades. He is also a noted polymath, a man of myriad interests and ideas that extend far beyond the felt of the poker table. Certainly the sort of open-minded freethinker that might consider taking part in such a wild experiment.

And this was wild. Konnikova had literally never played a hand of poker when she first approached Seidel about serving as her poker coach/tutor/guru. Her plan go from knowing nothing to the World Series of Poker Maine Event in a single year seemed absurd on its face. But again Seidels thoughtfulness and unconventional outlook made him the perfect candidate to help. Lucky for her, he said yes.

What followed was a months-long quest into the weird and insular world of poker. From learning the basics what beats what, betting etiquette, that sort of stuff to gradually climbing the competitive ladder, Konnikova immerses herself in the game, bringing her PhD in psychology and her longtime study of human behavior to the table.

It was never about making money. Rather, this journey was intended to give Konnikova insight into the role that chance plays in our lives and the illusion of control that we as humans tend to project onto the world around us. She had her share of epiphanies about behavior both her own and that of others.

She also started to win.

The initial year-long commitment led to legitimate success, including a title at one of the circuits touring stops. In the space of 12 months, she went from total donkey to full-on poker pro cashing in tournaments, receiving sponsorships, the whole shebang. In fact, this books release was delayed because of her mounting success. All in all, she got a good deal more than she bargained for.

The Biggest Bluff is a wonderful read, a piece of engaging experiential nonfiction reminiscent of the participatory work of George Plimpton. Konnikovas prose gifts are on full display throughout, capturing vivid snapshots of the poker world moments seedy and sublime alike. She also does incredible work in making her personal journey accessible; anyone who has ever sought to learn something new will see reflections of their own quest in these pages.

We spend lots of time with Seidel, a fascinating dude who becomes invested in Konnikovas success even as he continues his own work as one of the worlds best players. Hes not the only poker person we meet, though theres a wonderfully weird cast of characters sprinkled throughout the book.

Konnikova is also unafraid to introduce autobiographical elements into the mix, giving us a glimpse into how her time at the poker table is impacting her life outside the game. We see her self-awareness and self-worth grow. We meet members of her family, both supportive (her husband) and not-so-much (her frankly hilarious Russian grandmother). And we watch as the journey gradually but firmly alters her perspective on the world.

In terms of poker storytelling, The Biggest Bluff is probably the best weve seen since James McManuss incredible Positively Fifth Street. Even making the comparison borders on heresy, considering the esteem in which that book is held, but Id argue that what Konnikova has done here might even be its equal. A different sort of story, but one that is just as compelling.

The Biggest Bluff is a hell of a book. Anyone who has ever sat down at a poker table will love this tale of beneficial breaks, bad beats and yes, big bluffs. Its the literary equivalent of pocket aces with two more on the flop the absolute nuts.

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'The Biggest Bluff' is the nuts - Sports - Maine Edge

Cryptic 30,000-year-old burial cave reveals special afterlife treatment, long before the Egyptians – SYFY WIRE

Funeral rites emerged at the dawn of humanity. Rituals involved in the passage into the afterlife and proper care of the dead have always been sacred, but the reasons behind many funerary practices remain buried in time.

Deep in a French cave lies an unusual Mid-Upper Paleolithic burial site whose passages almost seem to echo with voices from the past. Most of the rites carried out some 25,000-30,000 years ago are still not well understood. Mysterious drawings of horses, oxen, and mammoths gallop across the rocky walls. Skeletal remains rest in graves smudged with red ochre, but why some of the bones are missing is still unexplained, as is the significance of who was buried there. Archaeologist Eline M.J. Schotsmans and her team are trying to demystify these secrets.

Grotte de Cusac in Dordogne, France, can only be studied by observation, since the French Ministry of Culture has designated the cave as a national heritage site with restricted access. Schotsmans recently published a study on her team's observations in PNAS.There has not yet been an excavation.

Though even gloved hands are barely allowed to touch anything, one aspect of the cave that could handle a more in-depth approach has been the intricate artwork. Figural drawings of animals are superimposed onto other animals, with horses and oxen dominant on the upper halfs, while woolly mammoths rule the lower halfs. It is known that there was a Paleolithic association of mammoths with women. Men during this era were the ones who would hunt such beasts, while women were relegated to the domestic realm, so the explicitly female representation remains unclear. So does the rest of the mural.

The meaning of the drawings must be a link with the human remains found in the cave," Schotsmans tells SYFY WIRE. Many of the engravings are superimposed and there are additions made to the engravings which indicate that the parietal art was not a final result. It was probably part of a narrative, of an art performance. It was meant to connect people and to exchange.

But who was the audience? Was it the living commemorating those who had gone before them, or the spirits of the dead?

It is possible there was some sort of mystical connection made with this visual narrative, like other forms of interaction with the dead. It was not uncommon for ancient tombs to be illustrated, but when pyramids rose in the Egyptian desert millennia later, their grand visions of the afterlife would be sealed away after the burial of a pharaoh. This much earlier example suggests that the drawings, for one reason or another, were constantly being added to. Perhaps the superimposed animals were symbolic of lines of ancestors who had already taken the journey to the underworld. These were the bodies that had been buried in and possibly painted with red ochre.

Ochre is a sign of symbolism. It shows that the deposition is deliberate and not just a dead body abandoned in the cave, Schotsmans explains. In general, the use of ochre is a sign of modern human behavior and cognitive development in the middle Stone Age. This is not usually questioned, as many burials from this time period have ochre, but it does say something about symbolism.

The Red Lady of Paviland is one of the most famous examples of bodies symbolically painted in red ochre. This partial skeleton dates to around the same time period the bodies at Grotte de Cusac were laid to rest, and named for the brilliant red color of the bones, which were later analyzed and found to be male. There is a suggestion of social status by the other artifacts buried with this man, which reveal that he may have been a hunter. He also appeared to have received preferential treatment. Evidence indicates that this was a ceremonial burial, and the Grotte de Cusac burials also appear to have involved ceremony and possibly special treatment of some sort.

We first have to do an excavation to study the age and sex of these individuals. The upper paleolithic society is considered as relativelyegalitarian, so I would not say that their burial indicates social status. It indicates social differentiation, but it is not sure on what this is based, Schotsmans says. This is still speculation. It could be related to ancestry. That certain individuals become ancestors. But it is unclear on what this is based.

Many found some way to keep their ancestors presence around. The Chinchorro people of what is now Chile would mummify their dead and bring these mummies into their homes to keep their ancestors alive. Every skeleton at Grotte de Cusac (with the exception of one) is missing a skull though the teeth were curiously left behind. The skeletons are thought to have been moved to this burial chamber (which was actually a series of abandoned bears nests) postmortem, and interacted with regularly. Could it be that the living also took certain bones into their homes so it would be as if the dead had never really left them?

It could well be that they took the crania with them so that the dead could stay in the world of the living, Schotsmans says. From ethnological examples, we see that it is not unusual that the dead continue their life with the living until a certain point through the manipulation of certain body parts. This could potentially point to some form of ancestry veneration. Of course, this is an interpretation of the observations and all speculative.

Until Schotsmans and others can shine more than just a flashlight on these mysteries, they will wait in the shadows.

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Cryptic 30,000-year-old burial cave reveals special afterlife treatment, long before the Egyptians - SYFY WIRE