Category Archives: Genetics

Genetics

Human Genetics Market Growth By Manufacturers, Type And Application, Forecast To 2026 – 3rd Watch News

New Jersey, United States,- Market Research Intellect sheds light on the market scope, potential, and performance perspective of the Global Human Genetics Market by carrying out an extensive market analysis. Pivotal market aspects like market trends, the shift in customer preferences, fluctuating consumption, cost volatility, the product range available in the market, growth rate, drivers and constraints, financial standing, and challenges existing in the market are comprehensively evaluated to deduce their impact on the growth of the market in the coming years. The report also gives an industry-wide competitive analysis, highlighting the different market segments, individual market share of leading players, and the contemporary market scenario and the most vital elements to study while assessing the global Human Genetics market.

The research study includes the latest updates about the COVID-19 impact on the Human Genetics sector. The outbreak has broadly influenced the global economic landscape. The report contains a complete breakdown of the current situation in the ever-evolving business sector and estimates the aftereffects of the outbreak on the overall economy.

Leading Human Genetics manufacturers/companies operating at both regional and global levels:

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The Human Genetics market report provides successfully marked contemplated policy changes, favorable circumstances, industry news, developments, and trends. This information can help readers fortify their market position. It packs various parts of information gathered from secondary sources, including press releases, web, magazines, and journals as numbers, tables, pie-charts, and graphs. The information is verified and validated through primary interviews and questionnaires. The data on growth and trends focuses on new technologies, market capacities, raw materials, CAPEX cycle, and the dynamic structure of the Human Genetics market.

This study analyzes the growth of Human Genetics based on the present, past and futuristic data and will render complete information about the Human Genetics industry to the market-leading industry players that will guide the direction of the Human Genetics market through the forecast period. All of these players are analyzed in detail so as to get details concerning their recent announcements and partnerships, product/services, and investment strategies, among others.

Sales Forecast:

The report contains historical revenue and volume that backing information about the market capacity, and it helps to evaluate conjecture numbers for key areas in the Human Genetics market. Additionally, it includes a share of each segment of the Human Genetics market, giving methodical information about types and applications of the market.

Reasons for Buying Human Genetics Market Report

This report gives a forward-looking prospect of various factors driving or restraining market growth.

It renders an in-depth analysis for changing competitive dynamics.

It presents a detailed analysis of changing competition dynamics and puts you ahead of competitors.

It gives a six-year forecast evaluated on the basis of how the market is predicted to grow.

It assists in making informed business decisions by performing a pin-point analysis of market segments and by having complete insights of the Human Genetics market.

This report helps the readers understand key product segments and their future.

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In the end, the Human Genetics market is analyzed for revenue, sales, price, and gross margin. These points are examined for companies, types, applications, and regions.

To summarize, the global Human Genetics market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

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Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage, and more. These reports deliver an in-depth study of the market with industry analysis, the market value for regions and countries, and trends that are pertinent to the industry.

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Human Genetics Market Growth By Manufacturers, Type And Application, Forecast To 2026 - 3rd Watch News

Genetics

New study finds love of affection heavily attributed to genetics in women – Arizona Daily Wildcat

Nature versus nurture: A debate that may only be applicable to women when it comes to a love of affection. A new study found a "latent genetic factor" accounting for up to 48% variance in affection for women with null effects in men.

Genes play a really important role in how affectionate women become as adults, said Kory Floyd, a professor of communication at the University of Arizona, specializing in the study of affection. It appears to play virtually no role in how affectionate men become we still are trying to figure out why.

According to Floyd, the original goal of the study was to answer the broad question of why many people are more affectionate than others. He described that throughout life, it is easy to observe levels of affection among people; some are very affectionate, some are somewhere between and some are just not comfortable with a lot of affection.

Even though the team assumed that environmental factors such as affectionate or non-affectionate households would play a big role, they also wanted to see how much of this trait is genetic.

The question wasnt which one is it is it nature or is it nurture we assumed that it would be a combination of both of those things, Floyd said.

To gather this information, Floyd worked with two other professors to find answers to their questions. The first professor Colter Ray was a former Ph.D. student of his who is now an interpersonal communication professor at San Diego State University. The second Chance York was an interpersonal professor at Kent State University specializing in behavioral genetics.

The three set off to find answers to their questions on the genetics of affection through surveying 464 pairs of twins, all ages 19 to 84, according to UANews.

Some of the pairs were identical twins, meaning that they inherited 100% of the same genes and some were fraternal twins, meaning that they inherited about 50% of the same genes.

The team assumed that if affection has a strong genetic component to it, then identical twins would likely show more similar levels of affection than fraternal twins.

What we expect to find is that the scores of twins who are identical are more similar to each other than the scores of twins who are fraternal because they are more closely related genetically, Floyd said.

In the survey sent out, every participant was able to report on their levels of affection using a measurement system that would assess it. Essentially, Floyd and the team wanted to find how similar scores would be within pairs.

Through the survey, it was found that for the female participants alone, around 48% of affection levels could be attributed to genetics and 52% could be attributed to environmental factors. In the males, genetic components played absolutely no role.

Floyd explained that this study brings the discipline of communication into a new realm.

In my field, we have a very strong assumption that differences between people in terms of their social behavior are almost entirely environmental, Floyd said. Unlike fields like psychology, for example, we dont have a history of looking at biology or genetics or heritability as explanations for social behavior.

He believes that this study could lead people to question the assumption in the communication discipline that most social behaviors are purely products of an environment.

Recently, Floyd has also participated in research on the concept of skin hunger. According to Psychology Today, skin hunger is a deep longing and aching desire for physical contact with another person.

During the times of COVID-19, the concept of skin hunger could not be more relevant.

I think a lot of people right now are really feeling like, I miss getting hugs, I miss holding hands or kissing or putting my arm around somebody, Floyd described. Its really the one thing that social media and Skype and Zoom dont allow us to do.

In research on deprivation of touch in the past, Floyd has found that it can definitely increase negative feelings like loneliness, anxiety, sleep issues and even a depressed immune system.

Though Floyd has not found any solutions to this issue, he believes that there are many ways to cope with the deprivation of physical attention. A major coping mechanism that Floyd suggests for those struggling with such a type of deprivation is to be around animals.

Petting a dog, petting a cat, petting a horse can have some of the same benefits in terms of calming us, in terms of anxiety reduction, in terms of stress reduction, Floyd said.

So, regardless of sex and your level of genetic cravings for affection, a reliable coping mechanism for the skin hunger you may be facing during these times could be to invest in a dog or cat.

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New study finds love of affection heavily attributed to genetics in women - Arizona Daily Wildcat

Genetics

Why Seattle Genetics Shares Climbed 48.7% in the First Half – The Motley Fool

What happened

Seattle Genetics (NASDAQ:SGEN) shares rose 48.7% in the first half, according to data provided by S&P Global Market Intelligence, after the company gained U.S. regulatory approval for its second drug in less than six months.

Image source: Getty Images.

The U.S. Food and Drug Administration in April approved Tukysa for patients with metastatic HER2-positive breast cancer after approving Padcev in December for locally advanced or metastatic urothelial cancer. In Padcev's first full quarter of commercialization, the drug generated $34.5 million in net sales, the company reported.

Urothelial cancer is the most common form of bladder cancer, and according to Grand View Research, the global drug market for the disease is growing at a 22.9% compound annual growth rate and is set to reach $3.6 billion by 2023. The global HER2-positive breast cancer market, at a 4.4% compound annual growth rate, may reach nearly $10 billion by 2025, a Global Data report shows. With these growing markets, Tukysa and Padcev have plenty of room to deliver sales increases.

Seattle Genetics' drug Adcetris, for Hodgkin lymphoma, was approved in 2011. Adcetris sales climbed 22% in the first quarter, and the company forecasts more growth as it works to further establish the drug as part of a frontline treatment, or first treatment given to patients.

The European Medicines Agency is currently reviewing Tukysa, so investors will be watching for a possible approval in Europe. Sales figures from Padcev's second quarter on the market will be another factor that could offer the stock direction in the second half of the year.

In more positive news, Seattle Genetics recently reported encouraging data from its phase 2 trial of tisotumab vedotin for recurrent or metastatic cervical cancer. The biotech company plans to speak with the FDA about the possibility of an accelerated approval process for the drug candidate. If the FDA agrees to an accelerated pathway, that likely will be another positive driver for Seattle Genetics' shares.

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Why Seattle Genetics Shares Climbed 48.7% in the First Half - The Motley Fool

Genetics

Shrimp stalwart hands over to Hendrix – The Fish Site

Dr Chamberlain has been leading the Hawaiian company for over 20 years and will continue his role as president of The Global Aquaculture Alliance.

Chamberlains career in aquaculture started in 1990 when he joined Ralston Purina Company directing their aquaculture feed programme in the Americas, Europe and Asia. After eight years, he moved to Monsanto, directing a programme on genetically selected marine shrimp, soy-based feed, and sustainable pond systems for marine shrimp.

His days as an entrepreneur started in 1999, when he established developed Black Tiger Aquaculture, an integrated shrimp farm in Malaysia, with Ken Morison. And in 2004, they established Integrated Aquaculture International, a technology company owning the Kona Bay L. vannameibreeding centre in Hawaii and operating a P. monodon breeding centre and farm in Brunei.

Over the last decade Chamberlain and his management team have built Kona Bay shrimp genetics into one of the leading brands in SPF shrimp broodstock, supporting shrimp farmers in achieving better performance in major shrimp producing countries. In addition, its food shrimp production under the Kauai Shrimp brand enjoys a reputation for premium quality in the Hawaiian and mainland US markets.

George Chamberlain commented: My career in the shrimp farming business has been deeply fulfilling. I owe whatever success our company has experienced to the support of colleagues, friends and family. Now its time to leave this enterprise in the capable hands of Hendrix Genetics whose leader, Thijs Hendrix, embodies the values and culture that our team so much admires.

Neil Manchester, managing director of aquaculture in Hendrix Genetics, said: We owe an immense amount to George, not just for bringing us into the shrimp breeding business with a world class operation like Kona Bay, but by sharing his knowledge, experience and contacts in the global industry that allows us to expand our reach and develop the Kona Bay brand in every shrimp production region. George will remain a friend and advisor, and we wish him an enjoyable retirement from shrimp breeding.

Hendrix Genetics acquired a majority shareholding in Kona Bay in 2017, as an entry point into shrimp breeding concentrating on acceleration of the breeding programme, strengthening the sales and technical support teams in Asia, and establishing a nucleus breeding and PL hatchery operation in Ecuador in 2019.

The company is investing heavily to realise a world class L.vannamei shrimp breeding operation in Hawaii, selling high quality Kona Bay broodstock to all major markets globally. The shrimp operations of Hendrix Genetics are expected to grow with the Ecuador development being a precursor to similar expansion in the major Asian markets. With the retirement of Chamberlain, Hendrix will acquire the remaining management shares in Kona Bay and subsidiaries, converting this to a 100 percent ownership.

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Shrimp stalwart hands over to Hendrix - The Fish Site

Genetics

Genetics vs. Genomics Fact Sheet – Genome.gov

Proteomics

The suffix "-ome" comes from the Greek for all, every, or complete. It was originally used in "genome," which refers to all the genes in a person or other organism. Due to the success of large-scale biology projects such as the sequencing of the human genome, the suffix "-ome" is now being used in other research contexts. Proteomics is an example. The DNA sequence of genes carries the instructions, or code, for building proteins. This DNA is transcribed into a related molecule, RNA, which is then translated into proteins. Proteomics, therefore, is a similar large-scale analysis of all the proteins in an organism, tissue type, or cell (called the proteome). Proteomics can be used to reveal specific, abnormal proteins that lead to diseases, such as certain forms of cancer.

Pharmacogenetics and Pharmacogenomics

The terms "pharmacogenetics" and "pharmacogenomics" are often used interchangeably in describing the intersection of pharmacology (the study of drugs, or pharmaceuticals) and genetic variability in determining an individual's response to particular drugs. The terms may be distinguished in the following way.

Pharmacogenetics is the field of study dealing with the variability of responses to medications due to variation in single genes. Pharmacogenetics takes into account a person's genetic information regarding specific drug receptors and how drugs are transported and metabolized by the body. The goal of pharmacogenetics is to create an individualized drug therapy that allows for the best choice and dose of drugs. One example is the breast cancer drug trastuzumab (Herceptin). This therapy works only for women whose tumors have a particular genetic profile that leads to overproduction of a protein called HER2. (See: Genetics, Disease Prevention and Treatment)

Pharmacogenomics is similar to pharmacogenetics, except that it typically involves the search for variations in multiple genes that are associated with variability in drug response. Since pharmacogenomics is one of the large-scale "omic" technologies, it can examine the entirety of the genome, rather than just single genes. Pharmacogenomic studies may also examine genetic variation among large groups of people (populations), for example, in order to see how different drugs might affect different racial or ethnic groups.

Pharmacogenetic and pharmacogenomic studies are leading to drugs that can be tailor-made for individuals, and adapted to each person's particular genetic makeup. Although a person's environment, diet, age, lifestyle, and state of health can also influence that person's response to medicines, understanding an individual's genetic makeup is key to creating personalized drugs that work better and have fewer side effects than the one-size-fits-all drugs that are common today. (See: Genetics, Disease Prevention and Treatment). For example, the U.S. Food and Drug Administration (FDA) recommends genetic testing before giving the chemotherapy drug mercaptopurine (Purinethol) to patients with acute lymphoblastic leukemia. Some people have a genetic variant that interferes with their ability to process this drug. This processing problem can cause severe side effects, unless the standard dose is adjusted according to the patient's genetic makeup. (See: Frequently Asked Questions about Pharmacogenomics).

Stem Cell Therapy

Stem cells have two important characteristics. First, stem cells are unspecialized cells that can develop into various specialized body cells. Second, stem cells are able to stay in their unspecialized state and make copies of themselves. Embryonic stem cells come from the embryo at a very early stage in development (the blastocyst staqe). The stem cells in the blastocyst go on to develop all of the cells in the complete organism. Adult stem cells come from more fully developed tissues, like umbilical cord blood in newborns, circulating blood, bone marrow or skin.

Medical researchers are investigating the use of stem cells to repair or replace damaged body tissues, similar to whole organ transplants. Embryonic stem cells from the blastocyst have the ability to develop into every type of tissue (skin, liver, kidney, blood, etc.) found in an adult human. Adult stem cells are more limited in their potential (for example, stem cells from liver may only develop into more liver cells). In organ transplants, when tissues from a donor are placed into the body of a patient, there is the possibility that the patient's immune system may react and reject the donated tissue as "foreign." However, by using stem cells, there may be less risk of this immune rejection, and the therapy may be more successful.

Stem cells have been used in experiments to form cells of the bone marrow, heart, blood vessels, and muscle. Since the 1990's, umbilical cord blood stem cells have been used to treat heart and other physical problems in children who have rare metabolic conditions, or to treat children with certain anemias and leukemias. For example, one of the treatment options for childhood acute lymphoblastic leukemia [cancer.gov] is stem cell transplantation therapy.

There has been much debate nationally about the use of embryonic stem cells, especially about the creation of human embryos for use in experiments. In 1995, Congress enacted a ban on federal financing for research using human embryos. However, these restrictions have not stopped researchers in the United States and elsewhere from using private funding to create new embryonic cell lines and undertaking research with them. The embryos for such research are typically obtained from embryos that develop from eggs that have been fertilized in vitro - as in an in vitro fertilization clinic - and then donated for research purposes with informed consent of the donors. In 2009, some of the barriers to federal financing of responsible and scientifically worthy human stem cell research were lifted.

Cloning

Cloning can refer to genes, cells, or whole organisms. In the case of a cell, a clone refers to any genetically identical cell in a population that comes from a single, common ancestor. For example, when a single bacterial cell copies its DNA and divides thousands of times, all of the cells that are formed will contain the same DNA and will be clones of the common ancestor bacterial cell. Gene cloning involves manipulations to make multiple identical copies of a single gene from the same ancestor gene. Cloning an organism means making a genetically identical copy of all of the cells, tissues, and organs that make up the organism. There are two major types of cloning that may relate to humans or other animals: therapeutic cloning and reproductive cloning.

Therapeutic cloning involves growing cloned cells or tissues from an individual, such as new liver tissue for a patient with a liver disease. Such cloning attempts typically involve the use of stem cells. The nucleus will be taken from a patient's body cell, such as a liver cell, and inserted into an egg that has had its nucleus removed. This will ultimately produce a blastocyst whose stem cells could then be used to create new tissue that is genetically identical to that of the patient.

Reproductive cloning is a related process used to generate an entire animal that has the same nuclear DNA as another currently or previously existing animal. The first cloned animals were frogs. Dolly, the famous sheep, is another example of cloning. The success rates of reproductive animal cloning, however, have been very low. In 2005, South Korean researchers claimed to have produced human embryonic stem cell lines by cloning genetic material from patients. However, this data was later reported to have been falsified.

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Genetics vs. Genomics Fact Sheet - Genome.gov

Genetics

5 Best Genetics Classes & Degree [2020] [UPDATED]

25 Experts have compiled this list of Best Genetics Course, Tutorial, Training, Class, and Certification available online for 2020. It includes both paid and free resources to help you learn Genetics and these courses are suitable for beginners, intermediate learners as well as experts.

With over 100 options, Coursera makes sure that you can enhance your skills in this rapidly evolving field of Genetics irrespective of your proficiency level. The programs are divided based on the difficulty levels namely beginner, intermediate and advanced. The classes here dont only allow you to build a strong foundation and apply this subject to the present research topics as well as developments. Top choices on the website include an introduction to genetics and evolution, classical papers in molecular genetics, introduction to the biology of cancer and bioinformatics for beginners.Check out our compilation of Best Bioinformatics Courses.

Key USPs-

Get acquainted with the necessary general jargon as well as practical ones.

The introductory lessons provide an overview of the content of the lectures and show how to make the most the experience.

Lots of exercises for understanding the problems from implementing them to solve the challenges of different levels of complexity.

The flexible deadline allows you to learn as per your convenience.

Complete all the exams and graded assessments that follow the lessons to earn the course completion certificate.

Duration: Self-paced

Rating: 4.8 out of 5

You can Sign up Here

This e-learning platform brings you a series of online courses from top academic institutions of the world. Get introduced to the concepts of cells, genome analysis, DNA among others. Apart from this, the classes will also help you with your coursework and beyond. Some of the top choices are DNA sequences, molecular biology, principles of synthetics biology, introduction to genomic data, graph algorithms in genome sequencing and statistical methods for gene mapping.

Key USPs

All the necessary concepts are explained clearly so that they can be helpful in building a strong fundamental.

The platform consists of individual and credit-eligible courses, micromaster program and more.

Work on the quizzes and assignments to assess your grasp on the topics covered.

The interactive lessons make learning a fun experience.

The study materials, videos, and exercises are available for free and the certification can be added for an additional fee.

Duration: Self-paced

Rating: 4.6 out of 5

You can Sign up Here

It is a fact that genomic technologies are changing the way many diseases are diagnosed and treated. This course spans the field from basic to advanced genetics and provides insight into health, risk factors, and disease prevention. By the end of the classes, you will have a solid understanding of all the topics covered. Have a look at our take on Best Molecular Biology Courses.

Key USPs-

As this is an intermediate level program, therefore, some prior experience in the topic can be beneficial.

-Understand the fundamental concepts, including gene structure and genetic variation.

Learn about the inheritance of diseases, including modes of inheritance, population-specific risks, and genetic testing.

See how increased knowledge of the human genome is applied in clinical settings, including through precision treatment of cancer and other diseases

The classes allow you to learn at a comfortable pace.

Duration: 10 weeks, 3 to 6 hours per week

Rating: 4.4 out of 5

You can Sign up Here

In this course, you will discuss the principles of genetics with application to the study of biological function at the level of molecules, cells and multicellular organisms including humans. Some of the topics covered include structure and function of genes, chromosomes and genomes, biological variation resulting from recombination, mutation, and selection, population genetics, use of genetic methods to analyze protein function, gene regulation and inherited disease.

Key USPs-

All the topics are covered in depth and at an undergraduate level.

Attempt the regular graded assignments to check your understanding of the subject and improve accordingly.

Suggestions for books and other resources are provided that can be used to supplement the learning experience.

Pass the final exam and other graded assessments to complete the program.

Lecture notes, exams and solutions and problem sets with solutions are available.

Duration: Self-paced

Rating: 4.4 out of 5

You can Sign up Here

This program is designed in a way that it takes a unified approach to transmission genetics, molecular genetics, cytogenetics, evolutionary genetics, molecular medicine, and developmental genetics. There is a focus on modern technological and experimental methodologies that are used in studying this field and genomics of prokaryotes, higher plants, and animals. Check our curation of Best Pathophysiology Courses.

Key USPs-

The introductory lectures help you to explore the different terms and concepts that will help you to build a strong foundation.

The classes are a combination of lectures and lab.

Reflect on how these mechanisms play a fundamental role in pathogenesis, treatment of diseases and maintenance of health.

The assessments will seek to emphasize important concepts.

The lectures are divided into sections which make it easy to follow along.

Duration: Self-paced

Rating: 4.4 out of 5

You can Sign up Here

So these were the 5 Best Genetics Classes, Course, Degree, Training & Certification available online for 2020. Hope you found what you were looking for. Wish you Happy Learning!

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5 Best Genetics Classes & Degree [2020] [UPDATED]

Genetics

Podcast: Let the light shineTackling eye disease with gene therapy – Genetic Literacy Project

In this episode, supported by the UK Medical Research Council, geneticist Kat Arney and reporter Georgia Mills explore how researchers are letting the light shine in, literally, by uncovering the underlying genetic faults that cause eye diseases and developing game-changing gene therapies to save sight.

Mills speaks with sight loss charity campaigner and fundraiser Ken Reid about his experiences of living with the genetic eye condition Retinitis Pigmentosa (RP)a hereditary disease that causes the gradual degeneration of light-sensitive cells in the back of the eye. He first realized that something was wrong with his sight when he was a party-going teenager in the 1970s.

I always had very poor eyesight and couldnt understand how people could do things in the dark, he says. Most people probably dont remember what discos in the 70s were like, but they were just dark. You had this lovely interaction where it was very noisy, it was very dark and there were some flashing lights. I could see nothing and trying to find somebody to dance with was a real torment. I didnt know how people managed it!

At the MRC Human Genetics Unit in Edinburgh, Chloe Stanton is searching for the gene faults that underpin RP and other hereditary eye diseases, with more than 100 RP genes identified so far. To find out more about what all these genes actually do, her colleague Roly Megaw is growing tiny mini-eyes in the lab from reprogrammed stem cells originally derived from skin samples including one from Reid himself.

Finally, Robin Ali at Kings College London is running clinical trials of gene therapy for inherited eye disorders. Theres been impressive progress in recent years, and Ali is hopeful that treatments will come through for people like Reid.

In the 25 years Ive been working on developing gene therapy for retinal degeneration, weve seen huge advances. I think we couldnt imagine how far we could come. I remember when I first started, we were working out ways to deliver genes to the retina and we were pleased if we saw just one or two cells that had taken up a virus and maybe expressing a gene for a couple of weeks. We are now able to rescue dozens of different animal models highly effectively. Its just a matter of time until this technology can be applied as effectively to humans.

Full transcript, links and references available online at GeneticsUnzipped.com

Genetics Unzippedis the podcast from the UKGenetics Society,presented by award-winning science communicator and biologistKat Arneyand produced byFirst Create the Media.Follow Kat on Twitter@Kat_Arney,Genetics Unzipped@geneticsunzip,and the Genetics Society at@GenSocUK

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Podcast: Let the light shineTackling eye disease with gene therapy - Genetic Literacy Project

Genetics

Wound Healing | Slow Wound Healing? It Could Be Your Genetics – runnersworld.com

Maybe you take a spill on an asphalt path and scrape your knees, and on that same day, a fellow runner friend does the same on a trail run. Days later, your friend only has minor evidence of the incident, while your scrapes still look fresh. Is it the difference between dirt and pavement?

The more likely answer is that the difference could be related to genetics, according to new research.

The study, published in PLOS Pathogens, found that genetic variability across 164 patients influences the composition of wounds and how they heal. Specifically, the forms of bacteria present in wounds have a genetic component that could make it easier to identify who would struggle with slower wound healing.

Researchers found that genetic variation in two genes, TLN2 and ZNF521, was associated with both the number of bacteria in wounds and the prevalence of common pathogens that causes slower healing.

Its important to note that the study was done on chronic wounds, which dont heal under a normal timeframe, according to lead study author Caleb Phillips, Ph.D., assistant professor of biological sciences and curator of genetic resources at Texas Tech University.

About two percent of Americans are afflicted with these kind of wounds, and they can be costly and frustrating to treat. Finding a genetic link like this could be a first step toward creating prevention strategies or developing new treatments, he told Runners World. It could also be used to identify patients who need to receive more aggressive therapy early on in wound care, rather than waiting weeks for the bodys healing process to kick in.

[Run faster, stronger, and longer with this 360-degree training program.]

You cant swap out your genes to help speed up the healing of your wounds. But there actually are some tactics that may cut down on healing time, previous research has found.

For example, get more sleep. A 2018 study in Journal of Applied Physiology that measured immune response and skin barrier restoration on people with minor blisters found that those who had restricted sleep showed slower wound healing than those who got adequate shuteye.

Good nutrition also plays a part, and research done on older people with chronic wound issues, which was published in Advanced Wound Care, found that common micronutrient deficienciesparticularly vitamin D, zinc, and B12could have a significant impact on wound healing.

Lifestyle changes like those mentioned above might not counteract genetic differences completely, but they may speed up healing to some degree, and also provide all the other benefits of quality sleep and good nutrition.

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Genetics

July: Genome sequencing rare diseases | News and features – University of Bristol

A research programme pioneering the use of whole genome sequencing in the NHS has diagnosed hundreds of patients and discovered new genetic causes of disease.

The project, the results of which were published in the journal Nature, offered whole-genome sequencing as a diagnostic test to patients with rare diseases across an integrated health system, a world first in clinical genomics.

Whole genome sequencing is the technology used by the 100,000 Genomes Project, a service set up by the government which aims to introduce routine genetic diagnostic testing in the NHS. The integration of genetic research with NHS diagnostic systems increases the likelihood that a patient will receive a diagnosis and the chance this will be provided within weeks rather than months.

The multi-centre study, led by researchers at the National Institute for Health Research (NIHR) BioResource together with Genomics England, demonstrates how sequencing the whole genomes of large numbers of individuals in a standardised way can improve the diagnosis and treatment of patients with rare diseases.

The researchers, including experts from the University of Bristol, studied the genomes of groups of patients with similar symptoms, affecting different tissues, such as the brain, eyes, kidney, blood, or the immune system. They identified a genetic diagnosis for 60 per cent of individuals in one group of patients with early loss of vision.

Principal investigators Andrew Mumford, Professor of Haematology, and Moin Saleem, Professor of Paediatric Renal Medicine, led the set-up of the programme and oversaw regional enrolment in the South West. Professor Mumford provided national oversight for blood related disorders, while Professor Saleem managed inherited kidney diseases.

Professor Mumford and researchers in the School of Cellular and Molecular Medicine collaborated with the Bristol NIHR Biomedical Research Centre and the University of Cambridge to develop ways to improve the genetic identification of blood disorders, contributing significantly to the breakthrough diagnostic potential.

Professor Mumford said: This pioneering study illustrates the power of whole genome sequencing for diagnosis of rare human diseases. The approach developed in this research has paved the way for the flagship 100,000 Genomes Project and the introduction of whole genome sequencing into standard NHS care.

Professor Saleem established the UK National Renal Rare Disease Registry, and the national and international NephroS (Nephrotic Syndrome) groups, based within the UK Renal Registry in Bristol. These provided recruitment, essential genetic data, and DNA collection for the study. Researchers in Bristol provided functional and clinical insights leading to the discovery of causative genes relating to kidney disorders.

Professor Saleem said: Rare diseases in their entirety are common, in that there are more than 7,000 different rare diseases in total affecting about 7 per cent of the population. Most have a genetic cause, so this research for the first time brings the most powerful genetic sequencing capabilities to apply across the whole health service, meaning all patients will now have the best possible chance of finding their individual genetic defect.

In the study, funded mainly by the National Institute for Health Research, the entire genomes of almost 10,000 NHS patients with rare diseases were sequenced and searched for genetic causes of their conditions. Previously unobserved genetic differences causing known rare diseases were identified, in addition to genetic differences causing completely new genetic diseases.

The team identified more than 172 million genetic differences in the genomes of the patients, many of which were previously unknown. Most of these genetic differences have no effect on human health, so the researchers used new statistical methods and powerful supercomputers to search for the differences which cause disease a few hundred needles in the haystack.

Using a new analysis method developed specifically for the project, the team identified 95 genes in which rare genetic differences are statistically very likely to be the cause of rare diseases. Genetic differences in at least 79 of these genes have been shown definitively to cause disease.

The team searched for rare genetic differences in almost all of the 3.2 billion DNA letters that make up the genome of each patient. This contrasts with current clinical genomics tests, which usually examine a small fraction of the letters, where genetic differences are thought most likely to cause disease. By searching the entire genome researchers were able to explore the switches and dimmers of the genome the regulatory elements in DNA that control the activity of the thousands of genes.

The team showed that rare differences in these switches and dimmers, rather than disrupting the gene itself, affect whether or not the gene can be switched on at the correct intensity. Identifying genetic changes in regulatory elements that cause rare disease is not possible with the clinical genomics tests currently used by health services worldwide. It is only possible if the whole of the genetic code is analysed for each patient.

Dr Ernest Turro, from the University of Cambridge and the NIHR BioResource, said: We have shown that sequencing the whole genomes of patients with rare diseases routinely within a health system provides a more rapid and sensitive diagnostic service to patients than the previous fragmentary approach, and, simultaneously, it enhances genetics research for the future benefit of patients still waiting for a diagnosis.

"Thanks to the contributions of hundreds of physicians and researchers across the UK and abroad, we were able to study patients in sufficient numbers to identify the causes of even very rare diseases."

Paper:

Whole-genome sequencing of patients with rare diseases in a national health system, by Ernest Turro et alin Nature.

There are thousands of rare diseases and, together, they affect more than three million people in the UK. To tackle this challenge, the NIHR BioResource created a network of 57 NHS hospitals which focus on the care of patients with rare diseases.

Based on the emerging data from the present NIHR BioResource study and other studies by Genomics England, the UK government previously announced that the NHS will offer whole-genome sequencing analysis for all seriously ill children with a suspected genetic disorder, including those with cancer. The sequencing of whole genomes will expand to one million genomes per year by 2024.

Whole-genome sequencing will be phased in nationally for the diagnosis of rare diseases as the standard of care, ensuring equivalent care across the country.

Read more from the original source:
July: Genome sequencing rare diseases | News and features - University of Bristol

Genetics

Genotype analysis of six popular dog breeds finds reduced genetic diversity within subpopulations – PRNewswire

VANCOUVER, Wash., June 30, 2020 /PRNewswire/ --Wisdom Health Genetics, the world's leader in pet genetics and makers of the WISDOM PANELdog DNA tests, announced today the publication in Canine Medicine and Genetics of a study conducted in collaboration with the University of Eastern Finland.

The study, Variation in breeding practices and geographic isolation drive subpopulation differentiation, contributing to the loss of genetic diversity within dog breed lineages,describes genetic subpopulation differentiation and related loss of genetic diversity discovered in six dog breeds: the Belgian Shepherd, English Greyhound, Finnish Lapphund, Italian Greyhound, Labrador Retriever, and Shetland Sheepdog.

Researchers examined the six popular dog breeds based on differential breeding strategies -- such as breeding for characteristics desired in 'sporting' compared to 'show' lines -- and geography using genotype analysis, finding that each of the breeds showed subpopulation differentiation contributing to a lack of genetic diversity.

For the Italian Greyhound and Shetland Sheepdog, the differentiation could be attributed to the founder effect -- or the reduction in genetic diversity caused when a population descends from a small number of 'founding' ancestors, combined withgeographical isolation based on continent. Breeder preferences accounted for the genetic structure of the remaining four breeds: the English Greyhound and Labrador Retriever breed structures were selected for either show, sport, or working lineages. Analysis of the Belgian Shepherd breed structure shed light on the genetic relationships between different subvarieties of the breed; analysis of the Finnish Lapphund revealed a relatively recent, unexpected split within that subpopulation due to breeder preference.

"These findings are yet another example of how the genetic data generated during our commercial testing at Wisdom Health Genetics can be used to gain insight into the population structure and diversity levels of breeds and their subpopulations," said Jonas Donner, PhD, Discovery Manager at Wisdom Health Genetics.

Though breed differentiation can serve important purposes, selection must be done critically and carefully to maintain healthy genetic diversity and increase gene flow between isolated populations.

"Breeding dogs to fulfill specific breed ideals, by definition, will result in a loss of variation over time; this differentiation is not generally negative. However, due to their size, many small breed populations are in danger of suffering from the accumulated effects of inbreeding depression over the generations," said study co-author Jaakko Pohjoismaki, PhD, senior researcher in genetics at the University of Eastern Finland. "Breed organizations should be more proactive in mixing the dogs between specialized lineages or closely related breeds to prevent deleterious effects of inbreeding depression."

It is essential to maintain a balance between preserving diversity within the breeds when selecting for desired characteristics; to continue responsible breeding, genetic diversity and selecting for positive health traits are central to keeping a population healthy.

"The results of this study highlight the importance of careful balancing between selection for desired traits and health, and avoiding loss of genetic diversity," said Rebecca Chodroff Foran, PhD, R&D Director at Wisdom Health Genetics. "Through our research, we aim to improve the lives of pets everywhere, and identifying opportunities to maintain genetic diversity will ultimately help create and support healthier populations."

Based on the observed loss of genetic diversity in subpopulations of the six breeds studied, the researchers recommend that breeders take steps to encourage genetic diversity, facilitating exchange of dogs across geographical borders and avoiding unnecessary artificial boundaries between lineages.

About the Subpopulation Genetic Differentiation Study:

About Wisdom Health Genetics

The mission of the Wisdom Health business is to strengthen the bond between pets and their people through world-leading insights powered by DNA. Wisdom Panel dog DNA tests - backed by the WISDOM HEALTH scientific research - can help pet parents plan better, care smarter, and love longer. For more than a decade, Wisdom Health scientific research contributed to develop state-of-the-art genetic tests for companion animals, revolutionizing personalized pet care. By unlocking the secrets of their dog or cat's DNA, pet parents and veterinarians can work together to tailor wellness programs that fit the one-of-a-kind needs of their pets. Wisdom Panel products are recommended by veterinarians, and the tests are currently offered by 7000+ veterinarians worldwide. For more information, visithttp://www.wisdompanel.com, or follow the Wisdom Panel brand onFacebook andInstagram.

About Kinship Labs

Advances in science, technology, health and nutrition offer an opportunity to transform the $100B+ pet care industry. With industry-leading data and analytics capabilities, a $100M venture fund and pioneering startup accelerator program, unique set of technology businesses like Whistle Labs and Wisdom Health Genetics,Kinship Labs is building the first-of-its-kind coalition of partners to transform the future of pet care. Kinship Labs is a business division of Mars Petcare, the global leader in pet health, nutrition and services, dedicated to one purpose:A BETTER WORLD FOR PETS. Follow @kinshipco to learn more.

About Mars Petcare

Part of Mars, Incorporated, a family-owned business with more than a century of history making diverse products and offering services for people and the pets people love, the 85,000 Associates across 50+ countries in Mars Petcare are dedicated to one purpose: A BETTER WORLD FOR PETS. With 85 years of experience, our portfolio of almost 50 brands serves the health and nutrition needs of the world's pets including brands PEDIGREE, WHISKAS, ROYAL CANIN,NUTRO, GREENIES, SHEBA, CESAR, IAMS and EUKANUBA as well as the Waltham Petcare Science Institute which has advanced research in the nutrition and health of pets for over 50 years. Mars Petcare is also a leading veterinary health provider through an international network of over 2,000 pet hospitals and diagnostic services including BANFIELD, BLUEPEARL, VCA, Linnaeus, AniCura and Antech. We're also active in innovation and technology for pets, with Wisdom Panel genetic health screening and DNA testing for dogs, the WHISTLE GPS dog tracker, LEAPVENTURE STUDIOaccelerator and COMPANION FUND programs that drive innovation and disruption in the pet care industry. As a family business guided by our principles, we are privileged with the flexibility to fight for what we believe in and we choose to fight for our purpose: A BETTER WORLD FOR PETS.

Media Contact:Lesley Albert[emailprotected]

SOURCE Wisdom Health

http://www.wisdompanel.com

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Genotype analysis of six popular dog breeds finds reduced genetic diversity within subpopulations - PRNewswire