Category Archives: Genetics

Genetics

Planting the milestones of human genetics in Senegal – Nature.com

I remember, after my PharmD graduation, how happy my mother was. She said, Now that you are done with school, you have to set up your own drugstore, find a good husband and settle down. However, my destiny was far from supporting this maternal wish since my aim at that time was to become a medical researcher. I had tremendous support from my eldest brother, Mouhamadou Ndiaye, an eminent professor of cardiac and vascular surgery at the University Cheikh Anta Diop (UCAD). I started with two years training in clinical biochemistry, hematology and immunology at the University of Cocody in the Ivory Coast.

Originally posted here:
Planting the milestones of human genetics in Senegal - Nature.com

Genetics

Genetic continuity and change among the Indigenous peoples of … – Nature.com

Golla, V. California Indian Languages (Univ. California Press, 2011).

Carpenter, J. P., Sanchez, G. & Villalpando, M. E. in Traditions, Transitions, and Technologies: Themes in Southwestern Archaeology (ed. Schlanger, S. H.) 245258 (Univ. Press of Colorado, 2002).

LeBlanc, S. A. in Archaeology without Borders: Contact, Commerce, and Change in the US Southwest and Northwestern Mexico (eds Webster, L. D. & McBrinn, M. E.) 107142 (Univ. Press of Colorado, 2008).

Mabry, J. B., Carpenter, J. P. & Sanchez, G. in Archaeology without Borders: Contact, Commerce, and Change in the US Southwest and Northwestern Mexico (eds Webster, L. D. & McBrinn, M. E.) 155183 (Univ. Press of Colorado, 2008).

Breschini, G. S. Models of Population Movement in Central California Prehistory (Coyoye Press, 1984).

Erlandson, J. M. et al. Paleoindian seafaring, maritime technologies, and coastal foraging on Californias Channel Islands. Science 331, 11811185 (2011).

Article CAS PubMed ADS Google Scholar

Johnson, J. R. & Lorenz, J. G. Genetics, linguistics, and prehistoric migrations: An analysis of California Indian mitochondrial DNA lineages. J. Calif. Gt. Basin Antrhopol. 26, 3364 (2006).

Google Scholar

DeLancey, S. & Golla, V. The Penutian hypothesis: retrospect and prospect. Int. J. Am. Linguist. 63, 171202 (1997).

Article Google Scholar

Merrill, W. L. et al. The diffusion of maize to the southwestern United States and its impact. Proc. Natl Acad. Sci. USA 106, 2101921026 (2009).

Article CAS PubMed PubMed Central ADS Google Scholar

Shaul, D. L. A PreHistory of Western North America: The Impact of Uto-Aztecan Languages. (Univ. of New Mexico Press, 2014).

Greenhill, S. J. et al. A recent northern origin for the Uto-Aztecan family. Preprint at SocArXiv https://doi.org/10.31235/osf.io/k598j (2023).

Hill, J. H. ProtoUtoAztecan: a community of cultivators in Central Mexico? Am. Anthropol. 103, 913934 (2001).

Article Google Scholar

Fowler, C. S. Some lexical clues to Uto-Aztecan prehistory. Int. J. Am. Linguist. 49, 224257 (1983).

Article Google Scholar

Scheib, C. L. et al. Ancient human parallel lineages within North America contributed to a coastal expansion. Science 360, 10241027 (2018).

Article CAS PubMed ADS Google Scholar

Rasmussen, M. et al. The genome of a Late Pleistocene human from a Clovis burial site in western Montana. Nature 506, 225229 (2014).

Article CAS PubMed PubMed Central ADS Google Scholar

Posth, C. et al. Reconstructing the deep population history of Central and South America. Cell 175, 11851197.e22 (2018).

Article PubMed PubMed Central Google Scholar

Hill, J. in Examining the Farming/Language Dispersal Hypothesis (eds Bellwood, P. & Renfew, C.) 331340 (MacDonald Institute for Archaeological Research, 2003).

Vellanoweth, R. L. AMS radiocarbon dating and shell bead chronologies: Middle Holocene trade and interaction in western North America. J. Archaeolog. Sci. 28, 941950 (2001).

Article Google Scholar

Moreno-Mayar, J. V. et al. Early human dispersals within the Americas. Science 362, eaav2621 (2018).

Article PubMed ADS Google Scholar

Bellwood, P. et al. First farmers: the origins of agricultural societies. Camb. Archaeol. J. 17, 87109 (2007).

Article Google Scholar

Glassow, M. A. et al. in California Prehistory: Colonization, Culture, and Complexity (eds Jones, T. L. & Klar, K. A.) 191213 (Altamira Press, 2007).

Kelley, J. C. & Reyman, J. in The Gran Chichimeca: Essays on the Archaeology and Ethnohistory of Northern Mesoamerica (ed. Reyman, J. E.) 103172 (Avebury Ashgate, 1995).

Coulam, N. J. The appearance of contracting stem dart points in the Western United States, diffusion or migration? KIVA 88, 355371 (2022).

Article Google Scholar

Barrett, S. A. The Washo Indians. Bull. Pub. Mus. Milwaukee 2, 113 (1917).

Google Scholar

dAzevedo, W. L. Handbook of North American Indians. Great Basin. Vol. 11 (Smithsonian Institution, 1986).

Eshleman, J. A. et al. Mitochondrial DNA and prehistoric settlements: native migrations on the western edge of North America. Hum. Biol. 76, 5575 (2004).

Article PubMed Google Scholar

Kaestle, F. A. & Smith, D. G. Ancient mitochondrial DNA evidence for prehistoric population movement: the Numic expansion. Am. J. Phys. Anthropol. 115, 112 (2001).

Article CAS PubMed Google Scholar

Siegel, J. S. in Demographic and Socioeconomic Basis of Ethnolinguistics 427484 (Springer, 2018).

Severson, A. L. et al. Ancient and modern genomics of the Ohlone Indigenous population of California. Proc. Natl Acad. Sci. USA 119, e2111533119 (2022).

Article CAS PubMed PubMed Central Google Scholar

Garca-Ortiz, H. et al. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas. Nat. Commun. 12, 5942 (2021).

Article PubMed PubMed Central ADS Google Scholar

Villa-Islas, V. et al. Demographic history and genetic structure in pre-Hispanic Central Mexico. Science 380, eadd6142 (2023).

Article CAS PubMed Google Scholar

Jones, T. L. & Klar, K. A. Diffusionism reconsidered: linguistic and archaeological evidence for prehistoric Polynesian contact with southern California. Am. Antiq. 70, 457484 (2005).

Article Google Scholar

Arnold, J. E. Credit where credit is due: the history of the Chumash oceangoing plank canoe. Am. Antiq. 72, 196209 (2007).

Article Google Scholar

Nakatsuka, N. et al. A Paleogenomic reconstruction of the deep population history of the Andes. Cell 181, 11311145.e21 (2020).

Article CAS PubMed PubMed Central Google Scholar

Kennett, D. J. et al. South-to-north migration preceded the advent of intensive farming in the Maya region. Nat. Commun. 13, 1530 (2022).

Article CAS PubMed PubMed Central ADS Google Scholar

Fernandes, D. M. et al. A genetic history of the pre-contact Caribbean. Nature 590, 103110 (2021).

Article CAS PubMed ADS Google Scholar

da Fonseca, R. R. et al. The origin and evolution of maize in the southwestern United States. Nat. Plants 1, 14003 (2015).

Article PubMed Google Scholar

Carpenter, J., Snchez, G., Snchez, I. & Vierra, B. J. in The Archaic Southwest: Foragers in an Arid Land (ed. Vierra, B. J.) 98118 (Univ. of Utah Press, 2018).

Carpenter Slavens, J. & Snchez, G. Los cambios ambientales del Holoceno medio/Holoceno tardo en el desierto de Sonora y sus implicaciones en la diversificacin del Yuto-Aztecano y la difusin del maz. Dilogo Andino https://doi.org/10.4067/S0719-26812013000100013 (2013).

Kennett, D. J., Kennett, J. P., Erlandson, J. M. & Cannariato, K. G. Human responses to Middle Holocene climate change on Californias Channel Islands. Quat. Sci. Rev. 26, 351367 (2007).

Article ADS Google Scholar

Fitzgerald, R. T., Rosenthal, J. S., Eerkens, J. W., Nicholson, D. & Spero, H. J. The distribution of Olivella grooved rectangular beads in the Far West. J. Calif. Gt. Basin Anthropol. 38, 241252 (2018).

Google Scholar

Hughes, R. E. Obsidian studies in California archaeology. Quat. Int. 482, 6782 (2018).

Article Google Scholar

Reimer, P. J. et al. The IntCal20 Northern Hemisphere radiocarbon age calibration curve (055 cal kBP). Radiocarbon 62, 725757 (2020).

Article CAS Google Scholar

Heaton, T. J. et al. Marine20the marine radiocarbon age calibration curve (055,000 cal BP). Radiocarbon 62, 779820 (2020).

Article CAS Google Scholar

Hendy, I. et al. Resolving varve and radiocarbon chronology differences during the last 2000 years in the Santa Barbara Basin sedimentary record, California. Quat. Int. 310, 155168 (2013).

Article Google Scholar

Nakatsuka, N. et al. Ancient genomes in South Patagonia reveal population movements associated with technological shifts and geography. Nat. Commun. 11, 3868 (2020).

Article CAS PubMed PubMed Central ADS Google Scholar

Dabney, J. et al. Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments. Proc. Natl Acad. Sci. USA 110, 1575815763 (2013).

Article CAS PubMed PubMed Central ADS Google Scholar

Korlevic, P. et al. Reducing microbial and human contamination in DNA extractions from ancient bones and teeth. BioTechniques 59, 8793 (2015).

Article CAS PubMed ADS Google Scholar

Sirak, K. A. et al. A minimally-invasive method for sampling human petrous bones from the cranial base for ancient DNA analysis. BioTechniques 62, 283289 (2017).

Article CAS PubMed Google Scholar

Rohland, N., Harney, E., Mallick, S., Nordenfelt, S. & Reich, D. Partial uracil-DNA-glycosylase treatment for screening of ancient DNA. Philos. Trans. R. Soc. Lond. B Biol. Sci. 370, 20130624 (2015).

Article PubMed PubMed Central Google Scholar

DeAngelis, M. M., Wang, D. G. & Hawkins, T. L. Solid-phase reversible immobilization for the isolation of PCR products. Nucleic Acids Res. 23, 47424743 (1995).

Article CAS PubMed PubMed Central Google Scholar

Rohland, N. & Reich, D. Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture. Genome Res. 22, 939946 (2012).

Article CAS PubMed PubMed Central Google Scholar

Maricic, T., Whitten, M. & Paabo, S. Multiplexed DNA sequence capture of mitochondrial genomes using PCR products. PLoS ONE 5, e14004 (2010).

Article PubMed PubMed Central ADS Google Scholar

Fu, Q. et al. An early modern human from Romania with a recent Neanderthal ancestor. Nature 524, 216219 (2015).

Article CAS PubMed PubMed Central ADS Google Scholar

Mathieson, I. et al. Genome-wide patterns of selection in 230 ancient Eurasians. Nature 528, 499503 (2015).

Article CAS PubMed PubMed Central ADS Google Scholar

Haak, W. et al. Massive migration from the steppe was a source for Indo-European languages in Europe. Nature 522, 207211 (2015).

Article CAS PubMed PubMed Central ADS Google Scholar

Li, H. & Durbin, R. Fast and accurate long-read alignment with BurrowsWheeler transform. Bioinformatics 26, 589595 (2010).

Article PubMed PubMed Central Google Scholar

See the original post here:
Genetic continuity and change among the Indigenous peoples of ... - Nature.com

Genetics

Flagship Pioneering Unveils Quotient Therapeutics to Create … – PR Newswire

Quotient's Somatic Genomics platform reveals new approaches to treat disease based on the vast genetic variation present in the body's trillions of cells

Company emerges from stealth after two years of platform development with an initial commitment of $50 million from Flagship Pioneering

CAMBRIDGE, Mass., Nov. 21, 2023 /PRNewswire/ -- Flagship Pioneering, thebioplatform innovation company, today unveiled Quotient Therapeutics, a company pioneering somatic genomics, the study of genetic variation at the cellular level, to discover therapeutics informed by new links between genes and disease. Flagship has made an initial commitment of $50 million to advance development of the company's platform following two years of development at Flagship Labs and pursue a pipeline of medicines across a wide range of therapeutic areas and modalities.

"The assumption that we each have a single genome turns out to be off by a trillion-fold," said Geoffrey von Maltzahn, Ph.D., Co-Founder and Chief Executive Officer of Quotient Therapeutics and General Partner, Flagship Pioneering. "All cells accumulate random genetic changes in their DNA, resulting in trillions of unique genomes in the body. Some genetic changes make a cell resistant or vulnerable to disease, while others can cause disease. We started Quotient to study the natural genetics library inside every tissue, discover gene variants that are beneficial, neutral, or disease-causing, and to harness that knowledge to develop the medicines of tomorrow."

Quotient's Somatic Genomics platform utilizes proprietary single molecule, genome sequencing technology to reveal the extensive variation encoded in the somatic genome at unprecedented resolution. Created by Flagship scientists in partnership with leading geneticists at the Wellcome Sanger Institute and the University of Texas Southwestern, this platform is able to study natural selection at the cellular level through four steps: phenotyping of cells from clinical tissue samples, isolation, single cell genotyping, and computation. As a result, naturally selected genes, proteins, and pathways are identified as prospective targets for the development of transformative therapies intended to cure, prevent, or reverse disease. Quotient's approach will enable the development of first-in-class drugs across a broad range of modalities and therapeutic areas, including immune disease, cardiometabolic disease, infectious disease, oncology, neurodegenerative disease, rare disease, and aging.

Jacob Rubens, Ph.D., Co-Founder and President of Quotient Therapeutics and Origination Partner, Flagship Pioneering added, "At Quotient, we're inspired by the maxim that 'Nothing in biology makes sense except in the light of evolution.' Our Somatic Genomics platform measures genetic changes underlying the evolution of cells in the body to make sense of disease, illuminating the path to a wide range of potentially curative medicines. Already, we've created the world's largest somatic genomes dataset, demonstrated the applicability of our platform to multiple therapeutic areas, and translated our genetic discoveries into drug discoveries."

Noubar Afeyan, Ph.D., Founder and CEO, Flagship Pioneering and Co-Founder and Strategic Oversight Board Chairman, Quotient Therapeutics, remarked, "One of the defining characteristics of the modern era of genetics has been the systematic comparison of people's genomes. Today, we stand at the precipice of a new era, enabled by the comparison of the trillions of genomes inside each one of us. Genetics has already created tremendous advances in human health, and Quotient is pioneering the next big leap forward."

Academic co-founders of Quotient include Professor Sir Mike Stratton, MD, PhD, Inigo Martincorena, PhD, and Peter Campbell, PhD, from the Wellcome Sanger Institute, and Hao Zhu, MD, from University of Texas Southwestern. In addition to von Maltzahn and Rubens, Quotient is led by Scott Hayton, Ph.D., Acting Chief Operating Officer, Caroline Fox,M.D., MPH, Senior Vice President, Head of Genetics and Target Discovery, and SimonBrunner, Ph.D., Co-Founder and Head of Platform. Quotient is co-located in Cambridge, MA and Cambridge, UK with research facilities in both cities.

To learn more about Quotient Therapeutics visit http://www.quotient-tx.com.

About Quotient Therapeutics

Quotient Therapeutics is the first company to systematically study the genetic variation and evolution of the trillions of cells inside the human body. The company's Somatic Genomics platform reveals novel links between genes and disease across a broad range of therapeutic areas, enabling the discovery of transformative medicines intended to cure, prevent, or reverse disease. Founded by Flagship Pioneering in 2022, Quotient is backed by experts in the field of somatic genetics.

About Flagship Pioneering

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. To date, Flagship has deployed over $3.4 billion in capital toward the founding and growth of its pioneering companies alongside more than $26 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 companies, including Denali Therapeutics(NASDAQ: DNLI),Foghorn Therapeutics(NASDAQ: FHTX),Generate:Biomedicines,Inari,Indigo Agriculture,Moderna(NASDAQ: MRNA),Omega Therapeutics(NASDAQ: OMGA),Sana Biotechnology(NASDAQ: SANA),Seres Therapeutics(NASDAQ: MCRB) andTessera Therapeutics.

Media Contact:[emailprotected]

SOURCE Flagship Pioneering

Visit link:
Flagship Pioneering Unveils Quotient Therapeutics to Create ... - PR Newswire

Genetics

Weaponized genomics: potential threats to international and human … – Nature.com

Lentzos, F. (ed.) Biological threats in the 21st century: The politics, people, science and historical roots (Imperial College Press, 2016).

Kania, E. B. Minds at War: Chinas pursuit of military dominance through the cognitive sciences and biotechnology. PRISM 8, 82101 (2019).

Google Scholar

Lentzos, F. Personalized war: How the genomics revolution will reshape war, espionage, and tyranny Aporia Magazine https://www.aporiamagazine.com/p/personalised-war (2023).

Cyranoski, D. China expands DNA data grab in troubled western region. Nature 545, 395396 (2017).

Article CAS PubMed Google Scholar

Kanokwongnuwut, P., Martin, B., Taylor, D., Kirkbride, K. P. & Linacre, A. How many cells are required for successful DNA profiling? Forensic Sci. Int. Genet. 51, 102453 (2021).

Article CAS PubMed Google Scholar

Zmorzynski, S., Styk, W., Klinkosz, W., Iskra, J. & Filip, A. A. Personality traits and polymorphisms of genes coding neurotransmitter receptors or transporters: review of single gene and genome-wide association studies. Ann. Gen. Psychiatry 20, 7 (2021).

Article PubMed PubMed Central Google Scholar

Dash, H. R. & Arora, M. CRISPRCasB technology in forensic DNA analysis: challenges and solutions. Appl. Microbiol. Biotechnol. 106, 43674374 (2022).

Article CAS PubMed Google Scholar

Cyranoski, D. Chinas crackdown on genetics breaches could deter data sharing. Nature 563, 301302 (2018).

Article CAS PubMed Google Scholar

Sero, D. et al. Facial recognition from DNA using face-to-DNA classifiers. Nat. Commun. 10, 2557 (2019).

Article PubMed PubMed Central Google Scholar

Andorno, R. in The Cambridge Handbook of New Human Rights: Recognition, Novelty, Rhetoric (eds von Arnauld, A. et al.) Ch. 26 (Cambridge University Press, 2020).

Go here to read the rest:
Weaponized genomics: potential threats to international and human ... - Nature.com

Genetics

New insights into genetic risk factors for early breast cancer in … – News-Medical.Net

A new research paper was published in Oncotarget's Volume 14 on October 4, 2023, entitled, "Determination of genetic predisposition to early breast cancer in women of Kazakh ethnicity."

Breast cancer (BC) is the most common type of cancer among women in Kazakhstan. To date, little data are available on the spectrum of genetic variation in Kazakh women with BC.

In this new study, researchers Gulnur Zhunussova, Nazgul Omarbayeva, Dilyara Kaidarova, Saltanat Abdikerim, Natalya Mit, Ilya Kisselev, Kanagat Yergali, Aigul Zhunussova, Tatyana Goncharova, Aliya Abdrakhmanova, and Leyla Djansugurova from the Institute of Genetics and Physiology, Kazakh Institute of Oncology and Radiology, Al-Farabi Kazakh National University, and Asfendiyarov Kazakh National Medical University aimed to identify population-specific genetic markers associated with the risk of developing early-onset BC and test their association with clinical and prognostic factors.

"To our knowledge, this is the first study using NGS [next-generation sequencing] technology to study the genetic predisposition to early-onset BC women from Kazakhstan and assess their impact on the patients' clinical outcomes."

The study included 224 Kazakh women diagnosed with BC (40 age). Entire coding regions (>1700 exons) and the flanking noncoding regions of 94 cancer-associated genes were sequenced from blood DNA using MiSeq platform. The researchers identified 38 unique pathogenic variants (PVs) in 13 different cancer-predisposing genes among 57 patients (25.4%), of which 6 variants were novel. In total, 12 of the 38 distinct PVs were detected recurrently, including BRCA1 c.5266dup, c.5278-2del, and c.2T>C, and BRCA2 c.9409dup and c.9253del that may be founder in this population. BRCA1 carriers were significantly more likely to develop triple-negative BC (OR = 6.61, 95% CI 2.4417.91, p = 0.0002) and have family history of BC (OR = 3.17, 95% CI 1.148.76, p = 0.03) compared to non-carriers.

"This study allowed the identification of PVs specific to early-onset BC, which may be used as a foundation to develop regional expertise and diagnostic tools for early detection of BC in young Kazakh women."

Source:

Journal reference:

Zhunussova, G., et al. (2023). Determination of genetic predisposition to early breast cancer in women of Kazakh ethnicity. Oncotarget. doi.org/10.18632/oncotarget.28518.

See the original post here:
New insights into genetic risk factors for early breast cancer in ... - News-Medical.Net

Genetics

Wow: Geneticists Created an Organism Immune to All Viruses – Popular Mechanics

Viruses are often incredibly hard to treat. Were certainly not strangers to that fact after the last few years. Theyre extremely adaptable and very hard to destroy, making them very dangerous to human health. Antivirals can sometimes help a little, but usuallyyou get a virus, youre stuck with it.

But what if instead of trying to treat these sneaky little beasts, we could stop them in their tracks before they even enter our cells? Create an organism thats basically immune to viruses right off the bat? Well, geneticists at Harvard claim theyve done just that.

In a recent study, a team of researchers announced that they had made an E. coli bacterium immune to all viruses. Well, all they could test in the lab, anyway.

More From Popular Mechanics

We cant say its fully virus-resistant, Akos Nyerges, genetics researcher and one of the authors of the study, said in a press release, but so far, based on extensive laboratory experiments and computational analysis, we havent found a virus that can break it.

The researchers decided to take a delete and trick approach in the creation of their super-organism. They first went in and stripped the bacterium of three of its codons, which are little chunks of genetic code. And they didnt just pick at randomthey carefully deleted the codons that viruses latch onto to begin replicating themselves.

So, problem solved, right? Wrong.

It turns out that viruses can bring their own versions of these codons into the cell and bypass the deletions altogether, kind of like bringing a power adapter on an international trip so you can plug your devices into wrong-shaped outlets.

So, in step two, the scientists got a little tricky with RNA. Specifically with tRNA, or transfer RNA. When a virus is trying, to begin the replication process, it basically plugs a strand of tRNA into a codon, and the codon prints out an amino acid. That process creates proteins.

But critically, if the codons print the wrong amino acid, nothing gets made. You just get a string of gibberish instructions that halt the viral duplication process in its tracks. So, the researcher team inserted strands of tRNA into the E. coli that would tell the codons brought in by the viruses to produce the wrong amino acids. Theoretically, the virus could bring in its own tRNA too, but the researchers seem convinced that their tRNA strands win that fight.

With the codons now printing out completely wrong amino acids and the viruss replication instructions being turned into nonsense, the infection was stopped before it even got started. With that success under their belt, the team eventually wants to use their new gene tech to create strands of virus-resistant bacteria that can be used to produce things like insulin.

And who knows? Maybe someday, well be able to extend that tech to ourselves.

Associate News Editor

Jackie is a writer and editor from Pennsylvania. She's especially fond of writing about space and physics, and loves sharing the weird wonders of the universe with anyone who wants to listen. She is supervised in her home office by her two cats.

Link:
Wow: Geneticists Created an Organism Immune to All Viruses - Popular Mechanics

Genetics

Where Myriad Genetics Stands With Analysts – Myriad Genetics (NASDAQ:MYGN) – Benzinga

May 4, 2023 5:01 PM | 2 min read

Analysts have provided the following ratings for Myriad Genetics (NASDAQ:MYGN) within the last quarter:

These 4 analysts have an average price target of $23.25 versus the current price of Myriad Genetics at $21.09, implying upside.

Enter your email and you'll also get Benzinga's ultimate morning update AND a free $30 gift card and more!

Below is a summary of how these 4 analysts rated Myriad Genetics over the past 3 months. The greater the number of bullish ratings, the more positive analysts are on the stock and the greater the number of bearish ratings, the more negative analysts are on the stock

The Best Report Benzinga Has Ever Produced

Massive returns are within possible within this market! For a limited time, get access to the Benzinga Insider Report, usually $47/month, for just $0.99! Discover extremely undervalued stock picks before they skyrocket! Time is running out! Act fast and secure your future wealth at this unbelievable discount!

Claim your $0.99 offer NOW!

This average price target has increased by 12.48% over the past month.

Stay up to date on Myriad Genetics analyst ratings.

If you are interested in following small-cap stock news and performance you can start by tracking it here.

Benzinga tracks 150 analyst firms and reports on their stock expectations. Analysts typically arrive at their conclusions by predicting how much money a company will make in the future, usually the upcoming five years, and how risky or predictable that company's revenue streams are.

Analysts attend company conference calls and meetings, research company financial statements, and communicate with insiders to publish their ratings on stocks. Analysts typically rate each stock once per quarter or whenever the company has a major update.

Some analysts publish their predictions for metrics such as growth estimates, earnings, and revenue to provide additional guidance with their ratings. When using analyst ratings, it is important to keep in mind that stock and sector analysts are also human and are only offering their opinions to investors.

If you want to keep track of which analysts are outperforming others, you can view updated analyst ratings along withanalyst success scores in Benzinga Pro.

This article was generated by Benzinga's automated content engine and reviewed by an editor.

2023 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

Originally posted here:
Where Myriad Genetics Stands With Analysts - Myriad Genetics (NASDAQ:MYGN) - Benzinga