Category Archives: Genetics

Why Sina, Eldorado Gold, and NewLink Genetics Slumped Today … – Motley Fool

The market was mixed on Thursday, with the Nasdaq Composite posting a modest gain while the Dow and S&P 500 stayed almost unchanged on the day. Events in Europe, including the U.K. election and a decision from the European Central Bank to keep interest rates stable, drew attention from international investors, but those in the U.S. didn't have a major response to those or other political events going on both domestically and across the globe.

Still, despite the quiet mood on Wall Street, some stocks suffered from bad news, and Sina (NASDAQ:SINA), Eldorado Gold (NYSE:EGO), and NewLink Genetics (NASDAQ:NLNK) were among the worst performers on the day. Below, we'll look more closely at these stocks to tell you why they did so poorly.

Shares of Sina fell more than 4% after the Chinese online media company detailed its plans to distribute a portion of the shares of microblogging specialist Weibo (NASDAQ:WB) that it still owns. Sina said that it will distribute one Weibo share for every 10 shares of Sina that investors own, leading to the distribution of roughly 7.14 million shares of Weibo. The distribution will take place on July 10, and it will reduce Sina's stake in Weibo from about 49% to 46%. However, Sina will retain voting control of Weibo, with the microblogging company's multiple share classes giving the online media player about 72% in terms of voting power. Weibo has been a big part of Sina's success, and some likely don't want to see Sina's stake in Weibo decline. Some of Sina's weakness also likely stemmed from the recent success of a key rival in the Chinese internet and e-commerce space, as rising competition will force Sina to up its game in order to keep pace.

Image source: Eldorado Gold.

Eldorado Gold stock lost 9% in the wake of news that one of the company's projects will likely become the subject of arbitration proceedings. Reports from Greece indicated that the head of the Greek energy ministry will ask the nation's litigation specialists to make preparations for arbitration over a gold mining project that Eldorado is seeking to develop in the northern part of the country. The Skouries project is a high-grade gold and copper deposit on the Halkidiki Peninsula, and Eldorado is looking to operate the company as an open pit mine for the first nine years, followed by an additional 15 years of underground mining. The Greek government wants to ensure that Eldorado will make good on its contractual obligations, but Eldorado is still hopeful that development will allow for operations to start on the open pit portion of the project by 2019.

Finally, shares of NewLink Genetics plunged more than 40%. Roche Holdings said that it had decided to stop working with NewLink on the cancer drug GDC-0919, returning its rights to help co-develop the candidate treatment back to its smaller partner. Many investors were surprised by the move, but early study results seemed to indicate only marginal benefits from adding NewLink's treatment to existing drugs in Roche's stable. With competitors' drugs apparently providing greater benefits, Roche chose to pull the plug. For NewLink, the news comes only days after poor study results on another candidate treatment for breast cancer, and shareholders have to wonder when the bad news will turn around for the company. For now, investors seem downbeat on NewLink's prospects going forward.

Dan Caplinger has no position in any stocks mentioned. The Motley Fool recommends Sina and Weibo. The Motley Fool has a disclosure policy.

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Why Sina, Eldorado Gold, and NewLink Genetics Slumped Today ... - Motley Fool

Genetics May Influence Ability to See Others’ Thoughts in Their Eyes – PsychCentral.com

Emerging research suggests our DNA influences the ability to read a persons thoughts and emotions from looking at their eyes. And it appears that genetic capability is prevalent among women but not men.

A new study expands on work initiated twenty years ago when a team of scientists at the University of Cambridge in the U.K. developed a test of cognitive empathy called the Reading the Mind in the Eyes Test (or the Eyes Test, for short).

They discovered that people can rapidly interpret what another person is thinking or feeling from looking at their eyes alone. It also showed that some of us are better at this than others, and that women on average score better on this test than men.

Now, the same team, working with the genetics company 23andMe along with scientists from France, Australia, and the Netherlands, report results from a new study of performance on this test in 89,000 people across the world.

The majority of these were 23andMe customers who consented to participate in research. The results confirmed that women on average do indeed score better on this test.

Study results appear in the journalMolecular Psychiatry.

The new study confirmed that genes influence performance on the Eyes Test. Investigators also discovered that in women, key genetic variants on chromosome 3 are associated with their ability to read the mind in the eyes.

The study was led by Varun Warrier, a Cambridge Ph.D. student, and Professors Simon Baron-Cohen, Director of the Autism Research Centre at the University of Cambridge, and Thomas Bourgeron, of the University Paris Diderot and the Institut Pasteur.

Interestingly, performance on the Eyes Test in males was not associated with genes in this particular region of chromosome 3.

Researchers also found the same pattern of results in an independent cohort of almost 1,500 people who were part of the Brisbane Longitudinal Twin Study, suggesting the genetic association in females is a reliable finding.

The closest genes in this tiny stretch of chromosome 3 include LRRN1 (Leucine Rich Neuronal 1) which is highly active in a part of the human brain called the striatum, and which has been shown using brain scanning to play a role in cognitive empathy.

Consistent with this, genetic variants that contribute to higher scores on the Eyes Test also increase the volume of the striatum in humans, a finding that needs to be investigated further.

Previous studies have found that people with autism and anorexia tend to score lower on the Eyes Test.

The team found that genetic variants that contribute to higher scores on the Eyes Test also increase the risk for anorexia, but not autism. They speculate that this may be because autism involves both social and non-social traits, and this test only measures a social trait.

Warrier said, This is the largest ever study of this test of cognitive empathy in the world. This is also the first study to attempt to correlate performance on this test with variation in the human genome.

This is an important step forward for the field of social neuroscience and adds one more piece to the puzzle of what may cause variation in cognitive empathy.

Bourgeron added, This new study demonstrates that empathy is partly genetic, but we should not lose sight of other important social factors such as early upbringing and postnatal experience.

We are excited by this new discovery, Baron-Cohen said, and are now testing if the results replicate, and exploring precisely what these genetic variants do in the brain, to give rise to individual differences in cognitive empathy.

This new study takes us one step closer in understanding such variation in the population.

Source: University of Cambridge

APA Reference Nauert PhD, R. (2017). Genetics May Influence Ability to See Others Thoughts in Their Eyes. Psych Central. Retrieved on June 8, 2017, from https://psychcentral.com/news/2017/06/08/genetics-may-influence-ability-to-see-others-thoughts-in-their-eyes/121659.html

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BRIEF-Newlink Genetics says Roche Group member Genentech informed co that it intends to return rights to IDO … – Reuters

June 8 Newlink Genetics Corp

* Newlink Genetics - on June 6, Genentech, a member of Roche Group, informed co that it intends to return rights to IDO inhibitor GDC-0919

* Newlink Genetics - rights co had licensed to genentech with respect to GDC-0919 will revert to co when termination becomes effective

* Newlink Genetics - research collaboration with Genentech for discovery of next generation IDO/TDO (tryptophan 2,3-dioxygenase) inhibitors continues Source text for Eikon: Further company coverage:

* Bain, Western Digital in group led by Japan state fund -sources

June 8 BlackRock Inc said on Thursday it hired Goldman Sachs' Heather Brownlie as its U.S. head of fixed-income ETFs.

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BRIEF-Newlink Genetics says Roche Group member Genentech informed co that it intends to return rights to IDO ... - Reuters

BRIEF-Takeda, Seattle Genetics announce Lancet publication – Reuters

CORRECTED-Investors expect to meet with Exxon on climate-impact report

HOUSTON, June 1 Exxon Mobil Corp investors will push to meet with oil company officials this summer to hash out elements of a climate-impact analysis following a shareholder vote calling for studies of technology and climate-related risks to its business.

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BRIEF-Takeda, Seattle Genetics announce Lancet publication - Reuters

Genetics authority to continue as director of US health institute – Reuters

Genetics pioneer Francis Collins will continue as director of the U.S. National Institutes of Health (NIH), the White House said in a statement on Tuesday.

President Donald Trump has proposed a 20 percent cut amounting to $5.8 billion to the NIH budget, a move which has been called a "catastrophe" by some heart doctors and researchers in the country.

Collins, a medical doctor with advanced degrees in chemistry, was nominated to head the NIH by former U.S. President Barack Obama in 2009. He said he was grateful for Trump's trust in his ability to continue to lead the NIH.

The NIH is one of the world's foremost medical research centers and has had a key role in important discoveries including the invention of magnetic resonance imaging, the mapping of the human genome and, more recently, the development of CRISPR, a genome editing tool that is fueling a boom in new treatments and products from medical and pharmaceutical companies.

(Reporting by Kanishka Singh in Bengaluru; Editing by Bill Trott)

NORRISTOWN, Pa. Bill Cosby's lawyers on Wednesday tried to undermine the account of the woman who accused him of sexually assaulting her in 2004, questioning apparent inconsistencies in her statements to police and suggesting she was after money.

The United States has joined a lawsuit accusing the city of Los Angeles of failing to develop affordable housing for disabled people despite accepting millions of dollars of federal funds for that purpose, the Department of Justice said on Wednesday.

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Genetics authority to continue as director of US health institute - Reuters

Release: Sophia Genetics using AI in liquid biopsies to accelerate early detection of cancer – Access Ai

news

Sophia Genetics, aleader in Data-Driven Medicine, has unveiled a new AI-powered solution for liquid biopsies to help with the detection of cancer and to monitor treatment.

This new application, unveiledat the 2017 Annual Meeting of the American Society of Clinical Oncology (ASCO), taps the analytical power of the companys artificial intelligence, SOPHiA, to help clinicians diagnose, treat, and monitor cancer earlier and more effectively by looking at circulating tumour DNA (ctDNA), or circulating tumour cells (CTC), contained in patients liquid samples such as blood, urine, and cerebral spinal fluid.

Compared to tissue biopsies, liquid biopsies allow clinicians to perform analysis of solid tumours and hematological malignancies at various time points to detect tumour progression and monitor treatments effectiveness. This new approach also represents a faster and less invasive alternative for patients.

The lack of a standardised analytical solution able to take into account different samples stability and low ctDNA levels has for a long time been a significant barrier to the widespread adoption of liquid biopsies in hospitals. SOPHiA solves these challenges by offering a standardised DNA analysis approach to liquid biopsy testing, built upon the network of 300 hospitals from 50 countries already using SOPHiA for genomic data analysis. Even with low ctDNA levels, SOPHiA provides indispensable insights into tumours profiles, straight from liquid samples.

One of the first users of SOPHiA for liquid biopsies, Prof. La Payen-Gay, co-investigator of the CIRCAN (CIRculating CANcer) program at the Hospices Civils de Lyon Laboratory, based in Lyon, France, explained, SOPHiA helps save precious time and resources and serves as an excellent benchmark for our laboratory as it detects and validates a more comprehensive list of variants. The companys analytical platform, SOPHiA DDM, is user-friendly and easy to navigate, making it possible for a user to be hands-on from benchtop to variant calling.

Speed and precision

Rather than waiting for months to detect changes on an imaging scan, SOPHiA allows clinicians to monitor a tumours progression with remarkable precision from a simple blood test. Faster and more accurate analysis eliminates undue anxiety resulting from biased answers and unclear response to heavy treatments, making regular status-check less stressful and painful for patients. SOPHiAs application for liquid biopsies is also available for clinical trials, making it possible to identify the patients most likely to benefit from new treatments.

To facilitate the interpretation of all the genetic variants detected by SOPHiA in ctDNA, the analysis results are presented in the companys OncoPortal, an interface dedicated to solid tumours and hematological malignancies, which experts can access on the companys online analytical platform, Sophia DDM. OncoPortal flags associations between human gene variants, disease causality, progression, drug efficacy, and toxicity to help the clinicians better leverage the data analysed by SOPHiA in order to provide personalised care to patients.

Jurgi Camblong, CEO and co-founder of Sophia Genetics, commented, By applying SOPHiAs state-of-the-art analytical power to liquid biopsies, clinicians can now leverage the collective intelligence of over 300 hospitals to help better diagnose, treat, and monitor cancer in a less invasive manner for patients. Now supporting tumor testing directly from blood samples with ctDNA, SOPHiA has the potential to benefit thousands of patients lives by giving clinicians access to the most advanced technology for cancer diagnosis and identification of successful treatments.

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Release: Sophia Genetics using AI in liquid biopsies to accelerate early detection of cancer - Access Ai

Using genetics to make best use of wind and solar in electrical systems – ScienceBlog.com (blog)

Scientists from the University of Geneva are using the rules of genetics to better understand how to incorporate wind and solar power into the current electrical grid to produce a renewable power system. The researchers published their study in IEEE/CAA Journal of Automatica Sinica (JAS), a joint publication of the IEEE and the Chinese Association of Automation.

Integration of intermittent generation into the electric network is a challenging task, as supply must always match demand, said Tim Mareda, a doctoral student at University of Geneva and an author on the paper.

The researchers examined the problems of wind and solar power reliability, storage, and delivery to areas with high demand for power across a large-scale area, such as Europe. Mareda and his team used Europes existing transmission map to create a grid of equally sized and spaced cells. They then simulated the mismatch between power generation and use every hour from years of electricity consumption data, and also estimated typical solar and wind generation.

To process this information, the researchers created an algorithm with set parameters, including the grids physical reach, the produced power of the renewable units, the storage capacity, and the ability of the system to charge and discharge power.

Designed to optimize the power exchange and use of available solar and wind power, the algorithm is derived from biology. Genes mutate, or share information, or select a specific output, to solve biological problems. It may not be the best solution for the entire body, but it provides a good solution for the individual genes. Mareda and his group used the same principles to optimize power generation and dispatch decisions through the simulated grid system, and they found it worked well.

From a technical perspective, and within our model assumptions, expanding the spatial distribution of weather-driven power sources is an effective way to manage intermittent generation, said Mareda. He noted that his teams study results are specific to Europe, but their approach can be used to study intermittent generation in any location.

Mareda and team plan to explore how wind and solar power systems could be coupled between different regions as a part of a large-scale renewable integration strategy.

Long term planning is crucial when evaluating options, Mareda said. Distributed generation harvested from wind and solar power can expand through both locally defined integration strategies and through large-scale power system designs. The paradigms are not mutually exclusive, and all options should be carefully considered to achieve a successful transition to a fully sustainable power system.

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Fulltext of the paper is available:

http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7894136 http://html.rhhz.net/ieee-jas/html/20170213.htm

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Oxford Genetics gets 500000 from Mercia Technologies – Tech City News

BioTech firm Oxford Genetics has raised 500,000 from Mercia Technologies.

The news comes after the company, which specialises in synthetic biology and DNA design, raised 1m from Mercia, which has a direct equity stake of 47.9% in the firm in October last year.

Oxford Genetics has so far raised 5.8m through a combination of grants and external investments and says it will use this latest round to expand its reach in the US market and further its growth.

Oxfords AI firm Oxbotica gets 8.6m to lead driverless car consortium

Dr Ryan Cawood, CEO of Oxford Genetics, commented on the raise: Mercias continued support has been instrumental in helping us to achieve the significant progress to date.

Our turnover has doubled in the last year and with this additional capital, we will be able to further expand the team, giving us the ability to build the most innovative technologies in the DNA and protein design market.

Dr Mark Payton, CEO of Mercia Technologies PLC, spoke about the companys trajectory over the past year.

Oxford Genetics has clearly demonstrated its ability to create market leading technologies and has been bolstered by an industry leading research and development team.

Payton went on to note that life sciences and bio-sciences continued to be a key sector for Mercia and one which they believe would deliver significant shareholder value over the medium term.

Follow Yessi Bello Perez on Twitter @yessibelloperez

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Oxford Genetics gets 500000 from Mercia Technologies - Tech City News

Poplar Healthcare Acquires Genetics of Memphis – 360Dx (subscription)

NEW YORK (360Dx) Laboratory services firm Poplar Healthcare today announced it has completed its acquisition of cytogenetics reference lab Genetics of Memphis.

Financial and other terms of the deal were not disclosed.

As part of the deal, Genetics' cytogenetics training facility one of five accredited cytogenetics training facilities in the US will be transferred to Poplar.

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New CEO for tilapia genetics firm – Fish Update

GENOMAR Genetics, which specialises in the tilapia industry, has appointed Alejandro Tola Alvarez as its CEO.

Alvarez (pictured), who took up his new role on June 1, will be responsible for innovation, operations and business development within the company, which is part of the EW Group.

He hasbeen part of the Genomar group since 2006, based in South-East Asia as chief operational officer and in Norway as chief technical officer.

We were very pleased to find a highly qualified internal candidate for the CEO position, said chairman Odd Magne Rdseth.

Alejandro has played a major role in both R&D and commercial development of the most reputable and professional genetic brands in global tilapia aquaculture.

He comes with a deep understanding of the tilapia operating environments and the opportunities of modern breeding technologies, such as genomics, to improve economic and environmental performance of the industry.

Alvarez is a qualified vet and has masters degrees in aquaculture and business administration.

GenoMar Genetics, based in Oslo with its main operation in Luzon, Philippines, has developed the Genomar Supreme Tilapia strain (GST) through more than 25 years of selective breeding.

The company was part of the Norway Fresh Group until March 2017 when EW Group concluded an agreement to acquire 100 per cent of GenoMar Genetics shares.

EW Group, based in Visbek, Germany, is a family owned holding company with more than 120 subsidiaries in over 30 countries.

The core business of the group, which has 9,000 employees worldwide, is animal breeding, animal nutrition and animal health.

Over the past 10 years, the group has expanded into the aquaculture sector and includes companies such as AquaGen, Aquabel, GenoMar Genetics and Vaxxinova.

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New CEO for tilapia genetics firm - Fish Update