Category Archives: Genetics

Clinical Cancer Genetics and Prevention Johns Hopkins …

Posted: June 9, 2017 at 4:48 pm

Johns Hopkins is a leader regarding thegenetics of cancer. Research in genetics,discoveredby Bert Vogelstein here at Johns Hopkins in 1983, has lead they way in discoveriesthroughout the country. Our experts in basic sciences, public health offer a wealth of expertiese for patients at a high risk of cancer.

At The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, we offer specifically designed programs to meet the needs of high-risk patients and families lead by Kala Visvanathan, M.D. This knowledge can help the person or families in planning health care for the future. Individuals assessed to have a higher than average risk of cancer will be referred to a specialist. They can talk to the person about having screening early to detect any signs of cancer as early as possible to ensure prompt treatment and successful outcomes.

The Clinical Cancer Genetics Program offers risk assessment, testing and long term management for men and women with a family history of cancer. The program is composed of three clinics:

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Genetics / Genomics SciPol Daily, 9 June 2017 | SciPol

Clinical OMICs Jackson Laboratory Expands Genomic Research Into China

The Jackson Laboratory (JAX) said it will expand into China through a strategic collaborative clinical genomics research agreement with three groups in Wenzhou. JAX will collaborate with the Wenzhou Municipal People's Government, Ouhai District People's Government (WZ), and Wenzhou Medical University and its affiliated hospitals (WMU), to conduct research on the genomic causes of disease.

Medical Xpress Stem cell treatment for lethal STAT1 gene mutation produces mixed results

Researchers report the first-ever study assessing how patients with "gain of function" mutation of the STAT1 gene respond to stem cell transplantation. It involved 15 young patients from nine different countries, each suffering a range of complications caused by the gene's mutation. Of these, only six survived a regime of stem cell transplantationwith five completely cured and disease free by the study's conclusion.

Motherboard CRISPR Is Not Accurate Enough to Save Us Yet

While this study brings some CRISPR limitations to the forefront, all of its claims may not stand up under scrutiny. We're definitely going to need more research to really figure out the extent of off-target mutations, when they happen, and why.

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Genetics / Genomics SciPol Daily, 9 June 2017 | SciPol

NewLink Genetics’ stock plunges as Genentech plans to returns rights cancer treatment candidate – MarketWatch

Shares of NewLink Genetics Corp. NLNK, +3.53% plunged 31% in premarket trade Thursday, putting them on track to open at a more-than 5-year low, after the biopharmaceutical company said Genentech planned to return the the rights to NewLink's IDO inhibitor GDC-0919 (navoximod), an immuno-oncology product candidate. The rights were part of a license agreement from October 2014. NewLink said the research collaboration with Genentech, a member of the Roche Group ROG, +0.12% for the discovery of IDO/TDO inhibitors will continue. "We are obviously disappointed in this decision," said NewLink Chief Executive Charles Link. "We remain committed to advancing our IDO pathway inhibitor indoximod, which continues to generate exciting data in combination with anti-PD-1 agents, cancer vaccines, and chemotherapy in multiple cancer types including melanoma, prostate cancer, acute myeloid leukemia, and pancreatic cancer." NewLink shares had tumbled in April after disappointing results of a trial in which indoximod was being tested in combination with Merck & Co.'s MRK, +1.88% Keytruda. The stock traded at $7.38 ahead of the open, the lowest price seen during regular trading hours since February 2012. The stock has plummeted 47% over the past three months, while the iShares Nasdaq Biotechnology ETF IBB, -0.22% has slipped 1.6% and the S&P 500 SPX, -0.08% has gained 8.7%.

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NewLink Genetics' stock plunges as Genentech plans to returns rights cancer treatment candidate - MarketWatch

Canada Is Using Genetics to Make Cows Less Gassy – WIRED

Number 1995 is a very special cow. Every day, this Holstein, mostly black with a white cat-face-shaped spot on her forehead, sticks her head into a trough that measures the exact amount of feed she eats. Shes had her genome partially sequenced, and will soon get her breath checked for methane several times a day.

Number 1995 also happens to be J. P. Brouwers favorite. I just like her character, the Canadian farmer says. It has nothing to do with how she looks. Shes a nice cow.

Brouwer, along with his father and two brothers at Sunalta Farms in central Alberta, runs the first commercial dairy farm contributing data to the Genome Canada project. One part of the project aims to increase feed efficiencygrowing cows as big as possible with as little food as possibleand reduce emissions of methane, a greenhouse gas that traps 30 times more heat per molecule than carbon dioxide. Eight years after scientists from the National Institutes of Health and the US Department of Agriculture sequenced the first cow genome , this project is trying to turn that information into more profitable, environmentally friendly cattle. Theyll be like Number 1995, but better.

Bovine livestock are responsible for about 9.5 percent of global greenhouse gas output, according to the Food and Agriculture Organization of the United Nations. Farmers are trying to reduce those emissions with lots of different strategies, starting with their diets. Researchers have tried adding flaxseed oil , garlic, juniper berries , and even seaweed to cow feed. Some scientists at Pennsylvania State University are even genetically modifying the bacteria in cow guts. Simpler tweaks can have an impact, too: Vaccinating cows against common viruses mean fewer cows die, letting farmers focus on raising fewer, healthier cows that live long into adulthoodcreating less methane as a result.

But scientists are also tweaking the cows themselves. The Genome Canada project, led by Filippo Miglior at the University of Guelph and Paul Stothard at the University of Alberta, harnesses labs in the US, UK, Denmark, Australia, and Switzerland to help identify cows that produce fewer greenhouse gases, with the ultimate goal of distributing the responsible genesconveniently transported in the form of bull semento areas that dont have the resources to develop their own greener cows.

Oliver Milman

How Can California Cut Methane Emissions if Cows Keep Cutting the Cheese?

Sarah Zhang

Farmers Are Manipulating Microbiomes to Help Crops Grow

Wired Staff

Origin of Modern Cows Traced to Single Herd

1995 is one of at least 10,000 cows that will be involved in the project, including those from two Canadian research farms, three Canadian commercial farms, and genome data from Migliors international allies. 1995s farmer, Brouwer, sent a little of her hair to a genome sequencing labin Canada, the farmers use Genome Quebec in Montreal, and every other country has an equivalent lab. These scientists fully sequence each bull, which costs about $1,100. A partial sequence like 1995s costs much less at about $40, but shell get a full sequence if she happens to have remarkable methane emissions and feed efficiency. We are going to try to identify the cows that do great and the cows that do poorly, says Miglior.

Its not easy to gather data on how much methane a cow actually produces: You can stick a cow in a closed chamber for a few days, but thats expensive and interrupts the cows daily routine. Some researchers use small backpacks that wrap around a cows head and measure how much methane it exhales. Migliors lab in Ontarioalong with the other farms involved in the projectuse a third option: a machine that puts out little cow snacks. Cows like Number 1995 stop by a couple of times a day to take a nibble. When the animal sticks its head in the machine, a vent sucks up a sample of its breath and measures the amount of methane and carbon dioxide.

That methane data is hard-won, and it wasnt easy for Miglior to get cattle researchers to share. But Yvette de Haas , a senior scientist with Wageningen Livestock Research in the Netherlands who is collaborating with Miglior, was won over by the promise of the work. Together, we knew more than each of us individually, she says. And the research could ultimately benefit ranchers and dairy farmers all over the world, not just in the developed countries where the research is taking place.

Once all the data is collected, Migliors labsupported by from the Canadian federal government, the Ontario and Alberta equivalents of the US state government, and dairy industry partnersworks to identify specific genetic markers associated with these traits. Finally, he makes recommendations to the farmers that breed the bulls to provide semen for the dairy cows. We can identify the best young bulls that carry the right markers for their particular traits, says Miglior. The best genes keep on accumulating.

Miglior says he considers over 80 other traits while making his recommendationsnot just feed efficiency and methane production, but also overall health. I want a cow to live a long, awesome and producing life, says Brouwer. Thats every farmers goal.

Another goal, of course, is making money. Brouwer thinks his participation in the genetics research will give him a leg up over his fellow dairy farmers. We would like to see cows with less potential leave the herd, he says. You want to keep the bestthats how you move forward. Once this project starts returning data, Brouwer will know which cows are most efficient, and can sell off the ones that would grow more slowly and produce more methane.

These changes will not happen overnight. Breeding, especially in livestock, is a long-term perspective, says de Haas. I cant change it from today to tomorrow, but I can change it in five years time. Miglior plans to monitor 1995who loves cuddling Brouwer when shes not snacking in her methane-measuring troughuntil at least 2019. If her genes turn out to be as exceptional as her personality, they might end up in Holsteins for many generations to come.

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Canada Is Using Genetics to Make Cows Less Gassy - WIRED

101-year-old woman credits genetics, being happy as keys to longevity – Sentinel-Tribune

Photo by J.D. Pooley/Sentinel-Tribune

Mary Frazier is 101 and lives at Grand Rapids Care Center in Grand Rapids.

Posted: Saturday, June 10, 2017 12:31 am

101-year-old woman credits genetics, being happy as keys to longevity By SARAH BAER, Sentinel-Tribune Staff Writer Sentinel-Tribune

GRAND RAPIDS -- Mary Frazier is turning 101 years old on Sunday and it is going to be a big celebration at Grand Rapids Care Center.

Jenn Wanless, director of the center, said that on Frazier's birthday they are going to have a luncheon with all of Frazier's family, and her closest friends along with the residents and staff. The meal provided will be many of Frazier's favorite foods, including meatloaf, scallop potatoes and pie.

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101-year-old woman credits genetics, being happy as keys to longevity - Sentinel-Tribune

New issue: Pig Progress focuses on biosecurity and genetics – Pig Progress (registration) (blog)

Subjects related to biosecurity as well as breeding/genetics constitute the core of the latest print edition of Pig Progress.

The cover article is aptly titled Will Big Data change the future of pig genetics? and aims to answer this main question. Seeing that Big Data are making way in all sectors of pig production, genetics is no exception.

In fact, author and pig genetics expert Benny van Haandel argues, the developments are happening right now. Increasingly more data are becoming available as it costs increasingly less to gather them and more techniques become available every day. Analysing them properly will take pig production to a next level. Page 24

Illustration: Shutterstock | blackdogvfx

Years ago, studies were carried out on the techniques which could ensure the gender of pigs being born. This concept has been revived by developments in the United States, where sex-sorted sperm was introduced as a concept first in cattle and this has now been extended into the swine business.

Are we heading towards a future with female finishers only? Correspondent Treena Hein reports on page 22.

A lot has been said about internal and external biosecurity. Internal biosecurity means that inside pig farms every protocol is followed and that farm staff are aware how pathogens may travel within a farm. As P.H. Rathkjen and Xavier de Paz, Boehringer Ingelheim, describe, several apps might be useful. Page 12

A pig producer cleaning out a pig facility. Not only internal biosecurity, but also external biosecurity is important to avoid pathogens from coming in.

For a reliable outcome of pig nutrition research, sometimes it is needed to know how feed transforms during digestion. Cannulating pigs is a way to tap some semi-digested feed from a pigs gastro-intestinal tract without having to cull the animal. At Novus farm Green Acres in Missouri, they have a range of cannulated animals. Pig Progress editor Vincent ter Beek captured their story. Page 20

How can the digestibility of amino acids be enhanced? At Dupont Animal Nutrition, they believe the combination of an enzyme and a probiotic has great possibilities. Scientist Laura Payling and swine platform lead Maria Walsh explain how exactly. Page 34

A potential zinc ban is keeping many authors busy these days including columnist John Gadd. He wonders what producers can do to alleviate a potential ZnO ban on page 9. In addition, welfare columnist Dr Monique Pairis-Garcia takes a closer look at loose house farrowing options for sows. Page 34

Landlocked yet insular in a way, that holds true for Switzerland. The country asks more and different things from its pig production chain than in the surrounding EU and therefore the countrys pig industry has its own dynamics. Which? Read Maarten Ceyssens contribution on page 10.

At Scotlands Rural College, Edinburgh, UK, much effort has been spent on aggression issues among pigs over 15 years. How does it originate, what are the consequences for pig farmers, and what can they do about it? Researcher Dr Irene Camerlink presents a useful summary as from page 6.

Aggression by two pigs as photographed during the trials. Photo: Marianne Farish

Every year, the worlds feed production is growing and so is the pig segment of that. Animal nutrition company Alltech summarised it in its annual overview; editor Emmy Koeleman of All About Feed made a concise summary. Page 14

Emmy Koeleman also interviewed Sren Bank, the chief commercial officer of Hamlet Protein. He explains the companys focus on young animal nutrition. Page 16

Sows do suffer from high temperatures and thus these may prove to be detrimental for their production performance. Animal nutrition company Lallemand shares some of their latest insights on how nutritional solutions can alleviate that. Page 27

To read all the articles in this issue, go to the magazine overview page and sign up with your current website login.

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Why Is NewLink Genetics Losing One-Third of Its Value Today? – Motley Fool

What happened

After a surprising decision by Roche Holding (NASDAQOTH:RHHBY) to exit its co-development deal on a new cancer drug, NewLink Genetics Corporation (NASDAQ:NLNK) shares were crashing 32% as of 1 p.m. EDT.

Hope that success for NewLink Genetics' IDO-inhibiting cancer drugs could get its share price back on track, following a disappointing trial failure last year, were dashed today when Roche announced it was returning rights to co-develop GDC-0919.

IMAGE SOURCE: GETTY IMAGES.

The news is a bit surprising given that Roche just presented data from a trial of GDC-0919 at the high-profile American Society of Clinical Oncology (ASCO) annual meeting this week.

However, it becomes a little less surprising when we dig into the data and discover that the benefit of adding GDC-0919 to Roche's PD-L1 checkpoint inhibitor Tecentriq didn't move the needle much. The combination did improve response rates, but the improvement appears too slight for Roche to justify committing any more research to it. Specifically, the overall response rate in patients diagnosed with various solid tumor cancers was only 9%, and all responses were partial responses.

Further sealing GDC-0919's fate was that the response rate appears to trail that of Incyte's (NASDAQ:INCY) epacadostat, a drug that has the same IDO-inhibiting target as GDC-0919. At ASCO, Incyte reported that teaming epacadostat up with Merck & Co.'s (NYSE:MRK) PD-1 checkpoint inhibitor Keytruda delivered overall response rates of 30% to 35% in various cancers, including kidney cancer and non-small cell lung cancer.

Roche's decision caps off a week of disappointing news at NewLink Genetics. On Jun. 2, it reported that another of its IDO-inhibitors, indoximod, failed a mid-stage breast cancer trial, casting doubt on its use in indications outside of melanoma, where results have been solid.

In April, management said that combining indoximod with Keytruda resulted in an objective response rate of 52%, and a disease control rate of 73%. Those are good numbers, but they don't appear to be much different from epacadostat, which delivered a 58% overall response rate in advanced melanoma patients when used alongside Keytruda, and a 74% disease-control rate.

Overall, IDO-inhibitors appear to work, but their efficacy might not be as strong across all cancers as hoped; undeniably, that puts peak sales forecasts for this class of drugs at risk. Only time will tell what NewLink Genetics does now that it has 100% rights to both indoximod and GDC-0919, but it may be a bit premature to assume that the company's IDO-inhibitors won't eventually make it to market.

Todd Campbell has no position in any stocks mentioned. His clients may have positions in the companies mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

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Why Is NewLink Genetics Losing One-Third of Its Value Today? - Motley Fool

Biology professor: Trump’s presidency will permanently alter human … – TheBlaze.com

A biology professor at the University of Washington in Seattle believes the stress caused by President Donald Trumps time in office will lead to a permanent change in human genetics.

Peter Ward, a professor who works in the earth and space sciences department of UWs College of the Environment, offered his bizarre prediction to Gizmodo earlier this weekwhen the publication asked a handful of evolutionary biologists, Can superhuman mutants be living among us?

Ward argued that significant traumas like abuse or military combat cancause permanent change to the human genome. He went on to suggest Trumps presidency is akin to those traumas and will have an evolutionary consequence on humanity.

Were finding more and more that, for instance, people who have gone through combat, or women who have been abused when you have these horrendous episodes in life, it causes permanent change, which is then passed on to your kids, he said. These are actual genetic shifts that are taking place within people.

Those shifts, Ward contended, can cause huge evolutionary change.

He added: On a larger scale, the amount of stress that Americans are going through now, because of Trump there is going to be an evolutionary consequence.

Earlier in his statement, the professor also predicted the U.S. military willmanipulate genetics to create some sort of superhuman soldiers.

A soldier whos much harder to bleed to death, or a soldier that doesnt need to drink as much water, or doesnt need to eat for five or six days, or doesnt need to sleep any one of these things would be an enormous advantage in warfare, he said.

This isnt the first time Ward has raised eyebrows for his ideas.

In his 2009 book The Medea Hypothesis: Is Life on Earth Ultimately Self-Destructive? Wardargued that life on earth will cause its own destruction in order to save the planet.

He argued at the time, The Christian Science Monitor reported, that life will self-destruct prematurely, many years before the sun, which he believes will begin to expand in roughly one billion years, burns the biosphere away.

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Biology professor: Trump's presidency will permanently alter human ... - TheBlaze.com

The monk who became the ‘father of genetics’ – Catholic Star Herald

This is the first piece in a series exploring Catholicism and science.

We know well the churchs stance that reason (ratio) can never be ultimately alien or antithetical to fides (faith), for God is the Source of all Truth. A disproportionate overtaxing of the aims and abilities of human nature as the basis for all social, ethical and political realities can and has led to totalitarian systems which have been disastrous for humanity (Fides et Ratio, 46). Yet the answer to these challenges is never a flight into the feeling and experience of unmitigated fideism, with no relationship to rational reflection, for this ends in religious expression withering into myth or superstition (FeR, 48).

This series will hope to emphasize the relationship between scientific thought and religious conviction, always recognizing the distinct spheres of both because using Scripture as a proof text for a scientific claim, or enshrining a scientific hypothesis as an indubitably revealed truth, is neither good science nor good theology. Yet faith and reason are famously recognized as the two wings on which the human spirit rises to the contemplation of the Truth.

These anthropological and theological claims do not preclude us from examining the contributions people of faith have made to the progress of human knowledge in various scientific disciplines. On the contrary, they impel us to do so. And with the proliferation of television commercials for private companies offering to help us explore our genetic past and the impact it has on our children and grandchildren, there is no better place to begin than with Gregor Mendel.

Mendel was born in 1822 in what is today the Czech Republic. An Augustinian monk, he studied math and botany in Vienna. When he returned to the monastery, he experimented with pea plants and came to realize that traits were passed on in independent pairings of what he coined dominant and recessive factors (now called genes), not inherited in equal proportions from each of the preceding generations as previously thought. He is thus known as the father of genetics.

Both the ability to identify genetically inherited diseases and to engineer plant varieties for more desirable qualities (e.g., corn with optimal kernel size, shape, color, durability, and resistance to pests) are indebted to the work of Mendel.

It is well known that prayer and praise formed and supported Mendels exploratory search for truths about life on our planet. He recognized the importance of creatureliness and what this implied: both limitation to our self-determination and a relationship with the Creator and the natural world in which we live.

Like Anselm of Canterbury almost a millennium before him, Mendel saw in his rigorous investigations a path toward union with the divine. As Mendels predecessor put it: Come now, insignificant man, fly for a moment from your affairs, escape for a little while from the tumult of your thoughts. Enter into the inner chamber of your soul, shut out everything save God and what can be of help in your quest for him Come then, Lord my God, teach my heart where and how to seek You, where and how to find You. Teach me to seek you, and reveal yourself to me as I seek, because I can neither seek you if you do not teach me how, nor find you unless you reveal yourself. Let me seek you in desiring you; let me desire you in seeking you; let me find you in loving you; let me love you in finding you.

Mendel died at 61 years of age after serving as a friar, botanist, abbot, and author. It was not until decades after his quiet death in the monastery that his genius was recognized by the international academic community, and his important role in this history of human self-understanding confirmed.

Collingswood native Michael M. Canaris, Ph.D., teaches at Loyola University, Chicago.

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The monk who became the 'father of genetics' - Catholic Star Herald

MerinoLink 2017 to feature latest in shearing, genetics and animal health – Sheep Central

An upright shearing platform will be demonstrated at the MerinoLink field day.

INNOVATIONS in shearing, genetics, pasture growth and animal health prediction, and the latest research on feed supplements will be outlined at the MerinoLink conference on June 21.

The conference at Mercure Goulburn from 8am-5pm will be followed by a field day on June 22 at Gunning to demonstrate an upright shearing platform.

Keynote speaker, Meat & Livestock Australia managing director Richard Norton, will outline how levies are being invested in the Merino production supply chain.

Australian Wool Innovation trade consultant Scott Carmody will give an insight into the wool market and Riverina sheep producer and 2017 RIRDC Rural Women of the Year, Sandra Ireson, of Hay, will cover programs aimed at fostering agricultural careers for young people.

The newly unveiled ASKBILL web-based program developed by the Sheep Co-operative Research Centre will be explained by Lu Hogan. The tool predicts pasture growth, animal performance and risks of flystrike, worm infection and weather stress.

A joint project between MerinoLink and Charles Sturt University evaluating the cost and production benefits of vitamin and mineral supplements will be outlined, along with genetic technology and the use of genomics at a commercial level.

NSW DPI technical specialist livestock systems Phil Graham will round out the afternoon sessions with future Merino production system challenges. Elmore ewe trial consultant Kieran Ransom will discuss the best sheep type for a combination of prime lamb and wool production.

An upright shearing platform developed by southern New South Wales wool grower Grant Burbidge will be the highlight of the MerinoLink field day at Merrill, Gunning, from 9am to noon on June 22. The platform shearing system aimsto increase efficiency in the shed and streamline sheep and wool handling, with no dragging or bending of sheep.

There will also be trade displays of sheep handling equipment, wool broking, animal health and industry research, and demonstrations of ram selection for commercial breeders.

Conference co-ordinator and MerinoLink chief executive officer Sally Martin said all members of the wool and sheep meats supply chain were welcome at the conference and field day.

Ms Martin said commercial producers would hear how MerinoLink research project outcomes could be incorporated in their enterprise to lift profitability.

There will be plenty of tips and tricks on using the new technologies available in the market place, she said.

Speakers will be also looking at the additional profit and genetic gain to be made from using electronic identification.

And, pasture is not forgotten with trends in pasture genetic improvement to be covered.

Master Australian storyteller Murray Hartin will be guest speaker at the MerinoLink dinner to be held at the Mercure Goulburn on June 21 from 6.30pm.

To register for the MerinoLink conference go to the MerinoLink website http://www.merinolink.com or contact Sally Martin on 0400 782 477, Donna Cummins on 0407 273 225 or email [emailprotected]

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