Category Archives: Genetics

Modest clinical trial win for Seattle Genetics, New Ra Pharma data on tap – STAT

Why the United States is no longer turning up

Why the United States is no longer turning up its nose at Caribbean medical schools

He may have invented one of neurosciences biggest advances.

He may have invented one of neurosciences biggest advances. But youve never heard of him

The Supreme Court decision thats shaking up biotech

The Supreme Court decision thats shaking up biotech

Pharmalittle: Shkreli jury selection begins; Will Trump pressure India

Pharmalittle: Shkreli jury selection begins; Will Trump pressure India to change patent laws?

Martin Shkreli defies advice to keep quiet before fraud

Martin Shkreli defies advice to keep quiet before fraud trial

Who will pay for CRISPR?

Who will pay for CRISPR?

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Modest clinical trial win for Seattle Genetics, New Ra Pharma data on tap - STAT

BRIEF-Atossa Genetics receives positive safety committee assessment – Reuters

Alimentation Couche-Tard wins US antitrust approval to buy CST, with conditions

WASHINGTON, June 26 Alimentation Couche-Tard Inc has won U.S. antitrust approval to buy rival CST Brands Inc on condition that it sell up to 71 gas stations in eight states, the Federal Trade Commission said on Monday.

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BRIEF-Atossa Genetics receives positive safety committee assessment - Reuters

How culture, passion and genetics are fueling a Nigerian takeover of US sports – CBS sports.com (blog)

It wasn't just coincidence to Bobby Burton. The 47-year-old Houston native had been covering college football recruiting for more than 20 years. With increased frequency, the best players he saw were more Americanized than American.

Burton lives in a Houston recruiting hotbed, but what he increasingly saw created a recruiting quandary. Who were these kids with the strange names? They were polite, dedicated and often studs.

They absolutely were Nigerian, or the second-generation offspring of Nigerians playing the hell out of American football.

"You're always looking for the next thing in recruiting," said Burton, a writer for 247Sports.

This one hit him between the eyes.

All of it made sense when Burton did the math. Nigeria is the seventh most populous nation in the world (190 million). It has the planet's largest black population. There are more Nigerian immigrants in the United States (376,000) than anywhere in the world. The Houston metro area is home to most Nigerians in the country (about 150,000).

Somehow their culture, their drive, their family structure and, oh yes, their bodies seemed to fit football.

With some meticulous research, Burton determined that in the 2016 NFL Draft there were as many players taken from Lagos, Nigeria, as from the city of Chicago (three).

"Unbelievable, unbelievable," said Hakeem Olajuwon, the acknowledged pied piper for Nigerian athletes after coming out the University of Houston in 1984 prior and becoming a member of the Naismith Memorial Basketball Hall of Fame.

"You can see the talents coming out."

It turns out, this phenomenon was bound to happen.

"I think it was kind of that moment in time," Burton said. "It's gone past the point of coincidence It's no longer just a anomaly. It's part of the fabric of football and football recruiting in this country."

Their story goes beyond college football -- or even college athletics. Forget any athletic stereotype, Nigerians have a fierce family pride and dogged belief in education -- particularly higher education -- that allows them to succeed in this country.

These noble West African natives and their descendants are the American Dream.

"There is an honor about them," Southern California Trojans coach Clay Helton said.

Helton counts at least five first- or second-generation Nigerians on his roster.

"They're such a regal people," said Chris Plonsky, the women's athletic director at Texas Longhorns .

Oh, and they can play. In the space of four picks at the end of the first round and beginning of the second of that 2016 NFL Draft, three were of Nigerian descent ( Ole Miss Rebels ' Robert Nkemdiche , Texas A&M's Germain Ifedi and Oklahoma State Cowboys 's Emmanuel Ogbah ).

While the NCAA doesn't keep statistics on nationality (only race), Nigerian influence on college sports is obvious. Among the Power Five, only the SEC didn't have at least one player of Nigerian heritage on its all-conference first or second teams in 2016.

The last three seasons, at least one player of Nigerian heritage has finished in the top 25 nationally in tackles.

At least 80 players of Nigerian ancestry have populated professional football, soccer, basketball and even car racing in recent years. In 1987, Christian Okoye ("The Nigerian Nightmare") became the first Nigerian-born NFL player.

Before Okoye, Olajuwon was the inspiration.

"You're totally right," said Emmanuel Acho , a Nigerian-American who played linebacker at Texas and in the NFL. "If you want to start with Hakeem Olajuwon or you want to start with Christian Okoye, [it doesn't matter]."

Hakeem's background in soccer and handball helped his footwork in basketball. Those Phi Slama Jama teams in the mid-1980s changed the game.

But what about the scores of second-generation Nigerians -- those born into a family with at least one Nigerian-born parent? In the 2016 draft alone, there were three times as many Nigerian players with hereditary ties to the country's dominant tribe -- the Igbo -- (six) than draftees from Florida State Seminoles (two).

Oluwole Betiku might be the next Nigerian phenom in that draft. The sophomore linebacker is already the talk of USC where they affectionately they call him "Wole" (woe-lay).

Betiku was discovered at a basketball camp in Nigeria. At age 15, he rode 11 hours in a bus to that camp in hopes of finding a better life for his impoverished family.

Desperation doesn't begin to describe it. Seventy percent of the Nigerian population is below the poverty line. Forty percent of the population is illiterate. The AIDS rate there is the highest in the world.

"We have oil everywhere," said Sonny Acho of his native land.

Acho is father of Sam and another Texas/NFL linebacker, Emmanuel. Sonny has become an icon not only in his Dallas community but also for his Nigerian outreach.

"We have a corrupt culture: Get all you can!" he said of Nigeria. "Only a few politicians live large. Millions live in poverty. These are the people that we are trying to go help."

Sam and Emmanuel have been on an estimated 15-20 mission trips back to their parents' homeland. They have recruited friends and teammates to provide basic needs to villages.

"People talk about modern-day miracles," Sam explained. "I saw a lady that was blind, and she received her sight through prayer."

That required some reconfirmation. The mission trip did include some doctors who were removing cataracts. Wasn't that what Sam witnessed?

"She starts praying, praying, praying," Sam said. "The next thing she says is, 'Amen.' I'm standing around the way just kind of seeing what's going on. The lady starts freaking out. They hold up this card and ask her what color it is.

"She says, 'Yellow.'"

A more conventional miracle: Out of that Nigerian camp, Betiku eventually got referred to former Penn State Nittany Lions star LaVar Arrington, who became his legal guardian and brought him to the U.S. Betiku didn't take up football until he was a sophomore at Serra High School in Los Angeles.

At that point, he was so nave to the sport, Wole shed his shoulder pads as an annoyance. Just getting on the field for the Trojans for five games as a freshman was a win.

"I'll never forget him absolutely breaking down into tears one day in our defensive team meeting," Helton said. "They had showed some tape on him and a little bit of praise. He said, 'Coach, if you could imagine where I was a couple of years ago to where I'm sitting right now. I just thank God for this opportunity.'"

If you want to secure one of these talents, you might want to place a call to Lou Ayeni. He is as plugged in to the Nigerian recruiting scene as anyone. Both parents of Iowa State Cyclones 's running backs coach are from Lagos, Nigeria's capital.

Babs and Flora have PhDs. Dad is a statistical engineer. Mom is a biomedical statistician. One sister, Tina, is a nationally noted oncologist who treated the mother of Iowa State coach Matt Campbell.

"She's trying to find a cure for ovarian cancer," Lou said. "My mom makes fun of me. You went to Northwestern Wildcats to coach football? I don't understand it."

That was after playing tailback and safety for the Wildcats under Randy Walker and surviving eight surgeries in his career. That was after his mother all but hand-picked the elite school for her son.

"My mom says, 'You're going to the best academic school you can go to,'" Lou recalled. "I was high school player of the year in Minnesota Golden Gophers . I was enamored with Wisconsin Badgers . My first Big Ten visit was Iowa Hawkeyes . They were really intriguing schools to me."

Flora then interjected: Nothing is happening until you visit Northwestern.

"We go through the academic piece. First thing she says is, 'You're coming here,'" Lou said. "Some Nigerian families are like that."

As an Ayeni, Lou did take the road less traveled. He knows those Dallas and Houston hotbeds.

Running back Kene Nwangwu was the state high jump champion out Dallas, not the kind of player to come to Ames, Iowa. He was offered by every Big 12 school. Iowa State got him.

"It was an easy sell for me," Ayeni said. "His family is very similar to my family -- 4.0 GPA, yes sir, no sir."

Ayeni says he can see Nigerian talent just by watching tape.

"Some of them," he said. "If I hear the name and watch them, I'll know if they're Nigerian."

Their names are often lyrical, peaceful and meant to convey both their faith and future -- Blessing, Sunday, Passionate, Peace, Promise, Princess.

Former Iowa State offensive lineman Oni Omoile was part of a royal bloodline in Nigeria. His nickname on the team quickly became "Prince."

"We know each other by our last names," Sonny Acho said. "You give me somebody's last name, not only will I know that person is from Nigeria, I will even tell you where the person is from. It tells you the tribe and the language the person speaks."

"Acho" means "I have found what I'm looking for," according to Sonny. Burton says he knows Nigerians by another definition.

"I've been doing this a long time," he said. "I can't remember a Nigerian kid ever having grade problems. It's not the physical nature of their ability. It's the maximization of what they have."

There are other cultures that stress education and family. Why are Nigerians different to be the subject of this talent/recruiting boom?

The Immigration and Nationality Act of 1965 was a direct result of the growing civil rights movement. It relaxed immigration quotas. The Refugee Act of 1980 made it easier for African immigrants to come here. That was important for those fleeing conflict-impacted areas, such as Nigeria.

That Nigerian U.S. population of 376,000 is roughly the size of New Orleans. That sample size has produced an athletic revolution.

WNBA players Chiney and Nneke Ogwumike -- from the Houston suburb of Tomball -- were the only other siblings besides the Mannings to be drafted No. 1 overall in a U.S. professional sports league (2014).

They are part of the fabric of a metro area. Half of all African immigrants in Houston are from Nigeria

"Why is there such a concentration in Houston?" asked Stephen Klineberg, a sociology professor at Rice Owls . "It's the classic story of immigration. You go where you know people. You go there because your cousin is there."

And the climate is roughly the same. The humidity and warmth of Houston is similar to Lagos. That gives rise to the some of the first families of Nigerian-American sports -- the Achos, the Orakpos, the Okafors.

All-American linebacker Brian Orakpo came out of Houston to win a national championship at Texas. He has been selected for the Pro Bowl in half of his eight pro seasons.

Emeka Okafor was the first member of his Nigerian family born in the United States. The former UConn basketball star and No. 2 overall draft pick played 10 NBA seasons. Distant cousin Jahlil Okafor was the No. 3 pick overall in 2015 out of Duke Blue Devils .

The Nigerian surge in athletics is best described another way: Half of all Nigerians have arrived in the country since 2000. Twenty-nine percent of those immigrants age 25 or older hold a master's degree. That's compared to 11 percent of the overall U.S. population. Eight percent of those Nigerians hold doctorate degrees compared to 1 percent of the U.S. population. This 2008 story calls them the most educated ethnicity in the U.S.

The NCAA's antiquated bylaws constantly remind us a degree doesn't necessarily equal an education. But in the Nigerian culture, education is the foundation for life.

Sam Acho could have played anywhere. His athletic talent was evident. But he was also being recruited by elite schools including several in the Ivy League. Sonny had to be convinced Texas was worthy of his son.

"Sam got into Texas' McCombs School of Business," Sonny said. "That solved the problem. Mack Brown basically knew we were strong people. Anything outside of that was going to cause a problem. They allowed us to be involved in the boy's lives. It's all about academics first and football second."

In 2010, Sam won the Campbell Trophy, the so-called "Academic Heisman" for the nation's top football scholar-athlete. Sam has a master's in international business. Emmanuel has a master's in psychology.

As kids, they led somewhat of a cloistered life. Such is the influence of parents. Sonny said former USC coach Pete Carroll once pulled Sam from a group of 300 and tried to get him to commit.

So you can sort of understand a natural skepticism.

"My kids couldn't do sleepovers," Sonny said. "I don't know what you have going on in your house I'm not willing to let my son go over there and something goes wrong and then they accuse my son of raping Many African parents will be like that."

A large part of this story is simple math and demographics. One in eight of the world's population is from Africa. The only countries larger are Pakistan, Brazil, Indonesia, the United States, India and China.

Nigeria also has the largest black population. There are more native Nigerians in the U.S. than from any other African nation.

In 1980, that number was 25,000. As those laws began to loosen, in every decade from the 1980s through the 2000s, at least 10 million immigrants came to the U.S.

Eighty-eight percent of those were of Asian, Latin American, Caribbean or African descent, Klineberg said.

"It's a new immigration stream that has never existed before in American history," he added.

Nigerian families tend to be large, accomplished and -- as mentioned -- extremely close. Florida State All-ACC defensive tackle Derrick Nnadi says he talks to each of his six siblings daily via social media.

"Every day we have a whole group chat," he said.

A brother, Bradley, is an actor in Southern California. A sister, Ashley, got into the nursing program at Old Dominion Monarchs . Derrick somehow ended up the kid with his hand in the dirt -- although one with a 3.12 GPA last semester.

"I have four jobs," Derrick said. "Go to class, study, get conditioned, play football. That really boils down to two jobs."

You shouldn't even have to ask. Consider his father, Fred Nnadi. He came to the U.S. with his brother decades ago determined to carve out a life as an engineer.

But like a lot of immigrants, he was hindered by his nationality and the language barrier.

"I went to a job interview one time. I had three degrees going in," Fred said. "I applied to be a meter reader. The supervisor doesn't have the degree I have.

"He hired me and didn't say a word. When I left, he started tell me he wished he had the education I had. I had to feed my family. That's why we emphasize education."

But perhaps the only reason Derrick is at Florida State in the first place is that Fred survived the brutal Nigerian civil war from 1967-70.

Up to two million may have died in the bloody conflict. It evolved as Nigeria was finding its identity as an independent nation after separating from the United Kingdom in 1960.

As a teenager, Fred voluntarily joined what he said were the equivalent of U.S. Army Rangers, fighting behind enemy lines. This was in the days of governmental conscription.

"It was a war of genocide It was a terrible war," Fred said. "That war, they have not recovered. I'm not kidding you. I don't care what anybody says."

Those who survived at least had the chance to pass on their genes in the United States. Fred's father had been a tribal chief back in the homeland with "many wives" who "when he walked on land, the ground shook."

"I have so many brothers and sisters," Fred said. "We were in the hundreds. He was a very great man. I have to tell you, when you look at Derrick, he's black and big You're looking at my father."

That memory of Chief Ezeoha explains some of the why the 6-foot-1, 312-pound Derrick became one of three "Seminole Warriors" on the team by throwing up 525 pounds on the bench.

"I have a video if you want to see it," Derrick said proudly. "I will never shy from showing the video."

After that civil war, a series of oppressive dictators emerged. Lately, the ISIS-affiliated Boko Haram have terrorized Nigerians.

Like all Nigerian athletes spoken to for this story, they seem to be Americans first. Some have been back to the homeland. All of them can't forget it.

"Killing this goat right in front of us and slicing it's neck," USC tight end Daniel Imatorbhebhe said while recalling a visit from his childhood. "[I remember] it running it around. We ate it later in the day. It was spicy."

In one sense, Imatorbhebhe is as American as the corner McDonald's. He was born in Nigeria but grew up in suburban Atlanta before signing with Florida Gators and immediately transferring to USC.

Imatorbhebhe's mother is a biomedical consultant. His father worked for a mortgage company before the financial crash. His brother, Josh, is a Trojans receiver.

"It's tough because it's like we're not really seen as in the some mold as an African-American kid," Daniel said. "Teammates have always said, 'Y'all are just built different. What do you attribute that to? Is it what you eat?'"

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How culture, passion and genetics are fueling a Nigerian takeover of US sports - CBS sports.com (blog)

Trust Is Influenced By Genetics But Distrust Is Not – ReliaWire

Trust may depend, at least in part, on genes. But, a new study suggests people may not inherit distrust in the same way.

The study explores distrust as a separate and distinct quality from trust. Lead author Martin Reimann, assistant professor of marketing at the University of Arizona, said:

This research supports the idea that distrust is not merely the opposite of trust. Both trust and distrust are strongly influenced by the individuals unique environment, but whats interesting is that trust seems to be significantly influenced by genetics, while distrust is not. Distrust appears to be primarily socialized.

For the study, researchers studied sets of adult identical twins, who have identical genetic relatedness, and adult fraternal (or non-identical) twins, who have different genetic relatedness.

Based on the core principles of behavioral genetics, if genetics explain variations in distrust and trust behaviors, then identical twins should behave more similarly to each other than fraternal twins, since the genes of identical twins are shared, while the genes of fraternal twins are only imperfectly correlated, Reimann says.

Studying the two different types of twins allowed researchers to estimate the relative influence of three different factors on twins trust and distrust trust behaviors:

For the research, 324 identical and 210 fraternal twins were asked them to decide how much money to send to another study participant (representing trust) and another task that asked them to decide how much money to take away from another participant (representing distrust).

Identical twin pairs behaved more similarly than the fraternal twin pairs in their trust behaviors but not their distrust behaviors, suggesting that genetics influence trust, but not distrust.

Overall, analyses estimated that trust is 30 percent heritable, while distrust is not at all heritable.

Meanwhile, the estimated contribution of shared environment to distrust was 19 percent, while shared environment didnt contribute at all to trust.

Unshared environment or the twins independent experiences in life had the biggest impact on both trust and distrust, with unshared experiences contributing 81 percent to distrust and 70 percent to trust.

In other words, whether a person has a propensity to trust or distrust is not inherited or commonly socialized. Instead, its influenced by unique experiences in life.

We all have a stock of past experiences that we draw on to help determine how we are going to behave in different situations, and future research should look at what particular types of life experiences could be the most influential on trust or distrust, Reimann says. Disposition to trust, however, is not a product of experience alone; genetic influence is also significant. But we dont see the same genetic influence with distrust.

Image: Argya Diptya CC-BY

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Trust Is Influenced By Genetics But Distrust Is Not - ReliaWire

Accelerated Genetics votes to join with Select Sires – Feedstuffs

Accelerated Genetics and Select Sires Inc. announced June 22 that they will be joining forces as a unified cooperative, effective July 1.

At a special delegate meeting held June 22, Accelerated Genetics delegates voted in favor of uniting Select Sires Inc. with Accelerated Genetics, formally finalizing the agreement recommended by both cooperatives' boards of directors.

Related: Select Sires, Accelerated Genetics to unify

Accelerated Genetics has been searching for a partner who could enhance the business and move it forward, Accelerated Genetics board chair Scott Dahlk said. Joining forces with Select Sires is a positive move for both member-owners and producers worldwide.

The official agreement states that Select Sires will acquire all Accelerated Genetics assets, integrating employees and independent sales representatives in each of their geographic member organizations. The decision to merge coincides with an already collaborative business relationship between the two cooperatives that began in 2001 under which each company shares ownership of World Wide Sires Ltd., which serves as the international marketing arm for both companies in Europe, Africa, Asia, the Middle East and Oceania.

By working together, we will be stronger, said David Thorbahn, Select Sires president and chief executive officer. The value and expertise gained by joining the people from both organizations allows us to offer our customers a broader genetics program in addition to an outstanding animal health product line." He added that working with the Accelerated Genetics team gives the organization "the ability to expand genetic research, technical support, service and programs with people who are passionate about the dairy and beef industries.

Accelerated Genetics and Select Sires are built on the same cooperative business principles and share similar operating structures. Each organization stems from innovative breeders who had a common vision to move the dairy and beef industries forward. Both cultures value the input of their member-owners and recognize the importance of their guidance in driving the need to produce superior genetics and outstanding reproductive programs.

The unification of both cooperatives will create a well-rounded genetics program and solution-based animal health care product line that will fit the needs of dairy and beef producers worldwide, the announcement said. Producers can expect to continue working with highly qualified, passionate individuals who know and understand the cattle breeding industry.

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Accelerated Genetics votes to join with Select Sires - Feedstuffs

Are New Zealand sheep genetics the way forward? – Agriland

With New Zealand (NZ) sheep genetics in the flock, it might be possible to reduce the labour requirement around lambing.

That is according to Teagasc Post Doctoral Researcher, Fiona McGovern, who is carrying out a study on the Ireland New Zealand across breed Animal Comparison (INZAC) flock.

The research has shown that NZ sheep have a lambing difficulty of 2.2%. This was compared to 3.6% for the 5-star replacement Irish sheep and 9.7% for the 1-star replacement Irish sheep.

NZ sheep also produced more milk when compared to the two Irish groups, according toTeagascResearch officer for Beef and Sheep Genetics,Nirn McHugh.

The INZAC flock was originally formed in 2015, with sheep imported from New Zealand.

The flock consists of 180 ewes: 60 of NZ origin; 60 5-star replacement Irish; and 60 1-star replacement Irish. Each group of 60 was split into 30 Texels and 30 Suffolks.

These two breeds were selected because they are the two most popular terminal breeds in Ireland, with the flock bred using artificial insemination (AI) during autumn 2015.

The stocking rate for the INZAC flock is 12 ewes/ha and the total area allocated is 15ha: three farmlets of 5ha. Some 130kg of chemical nitrogen/ha per year is applied. The flock is mid-season lambing within a grass-based production system.

According to the results of the study, the type of breed had a direct impact on the performance of the lamb.

The NZ breed had fewer days-to-slaughter when compared to the elite Irish and Irish low. It took 155 days to slaughter the NZ lamb and 164 days to slaughter the elite Irish, whereas it took 178 days for the Irish low.

96% of NZ lambs were drafted from grass, while 82% of elite Irish and 69% of Irish low were drafted from grass. Almost all NZ lambs were slaughtered from a grass-based diet only.

Speaking at the Teagasc Sheep Open Day in Athenry on Wednesday, June 21, McGovern said the study which isa four to five-year project and will continue for another two years did not take into accountthe area of labour requirement.

Apart from the INZAC flockstand, the open day also showcased stands that focused on grassland management, ewe prolificacy and age of lambing.

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Are New Zealand sheep genetics the way forward? - Agriland

Fungal Genetics Conference Q&A identifying new L maculans effectors, a fungal pathogen of oilseed rape – BMC Blogs Network (blog)

Fungal Biology and Biotechnologyrecently attended the 29th Fungal Genetics Conference in California. Whilst there, we invited three young scientists who presented excellent posters to take part in a Q&A. In this blog we talk to Julie Gervais, a third year PhD student in INRA BIOGER (France) whos currently working on a fungal pathogen of oilseed rape, Leptosphaeria maculans.

Julie Gervais 23 Jun 2017

Leptosphaeria maculans is an oilseed rape pathogen and is responsible for the stem canker disease.

Pixabay

My name is Julie Gervais and I am a third year PhD student in INRA BIOGER (France) working on a fungal pathogen of oilseed rape, Leptosphaeria maculans, which is responsible for the stem canker disease. This fungus has two colonization stages of the plant. During the first stage, the fungus infects leaves and cotyledons (the first leaves to appear from a germinating seed). Once in the leaves, the fungus has a short biotrophic stage of 10 days and then switches to necrotrophy.

Following this primary leaf infection, L. maculans grows inside the stem tissues during a long endophytic systemic colonization. This colonization is completely symptomless and may last up to 9 months. I am aiming to gain a better understanding of how the fungus can grow inside the oilseed rape stem for several months without causing any symptoms. I am particularly focused on the identification of new effectors, secreted proteins, produced by the fungus enabling it to develop itself efficiently into the plant.

I am particularly focused on the identification of new effectors, secreted proteins, produced by the fungus enabling it to develop itself efficiently into the plant.

By transcriptomic analysis, I identified late effector candidates, under-expressed in the early colonization stage and over-expressed in the infected stems. My analysis revealed a link between the regulation of expression of effectors and their genomic location: the late effector candidates, putatively involved in systemic colonization, are located in gene-rich genomic regions, whereas the early effector genes, over-expressed in the early colonization stage, are located in gene-poor regions of the genome. These results were recently published in an article of Molecular Plant Pathology.

I am also trying to confirm the role of effector for six late effector candidates: I am measuring the impact of the silencing of these genes on the fungal growth inside the stem. Preliminary results indicated that the silencing of one of these candidates induced smaller necrosis on the stem.

Another aim of my thesis is to identify new resistances to control L. maculans. The identification of new effector genes would contribute to the identification of new resistance genes specific to these effectors.

During my studies, I became more interested in the understanding of interactions between plants and micro-organisms, so I decided to pursue this interest in my thesis on L. maculans and its host, oilseed rape. I especially enjoy trying to dissect the network of interactions between the two organisms and to be able to apply such findings in the effective control of plant diseases.

I would advise young scientists to stay focused on what they are interested in and to always take pleasure in what they do. Science is fun!

I was able to attend to the Fungal Genetics Conference thanks to travel fundings from the Acadmie dagriculture (grant Jean & Marie-Louise Dufrenoy) and from the Genetics Society of America.

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Fungal Genetics Conference Q&A identifying new L maculans effectors, a fungal pathogen of oilseed rape - BMC Blogs Network (blog)

Florida higher education official said women may earn less than men because of genetics – New York Daily News

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Florida higher education official said women may earn less than men because of genetics - New York Daily News

Did That Fox Just Wag Its Tail? Inside a Bold Genetics Experiment – Undark Magazine

One spring morning in 1963, a Soviet scientist named Lyudmila Trut was making the rounds at a commercial fox farm, visiting several litters of three-week-old fox pups. As she approached one cage, a fuzzy male pup named Ember began to wag his tail. This simple, back-and-forth movement was a startling sight. Several years earlier, Trut and another scientist had launched an audacious experiment to solve the mysteries surrounding dog domestication by trying to replicate the process in foxes. Embers restless tail was the best sign yet that they were succeeding.

BOOK REVIEW How to Tame a Fox (and Build a Dog): Visionary Scientists and a Siberian Tale of Jump-Started Evolution, by Lee Alan DugatkinandLyudmila Trut (University of Chicago, 240 pages).

A six-decade project that challenged conventional wisdom about domestication and evolution and is still yielding new scientific insights.

Wagging their tails in response to humans is one of the signature behaviors of dogs, and until that day, they were the only animals observed to do so, Trut and the biologist Lee Alan Dugatkin write in their new book, How to Tame a Fox (and Build a Dog). And yet, here was Ember, who appeared to be wagging his tail due to a new emotional response to people, and if other pups also began to do so, that might prove to be a big step in the process of domestication. This comprehensive book provides an inside look at one of the most remarkable and longest-running experiments in science. Its a rich and fascinating story of a six-decade project that challenged conventional wisdom about domestication and evolution and is still yielding new scientific insights today.

The fox experiment was the brainchild of Dmitri Belyaev, a geneticist who worked at Moscows Central Research Laboratory on Fur Breeding Animals, where he was tasked with helping fox breeders produce animals that would earn more money for the Soviet Unions lucrative fur industry. But as he worked with the often-ferocious foxes that lived on Soviet fur farms, he began to wonder how humans had managed to tame the wolf a close relative of the fox into the docile domestic dog. Fossil evidence provided snapshots of how wild animals had changed over the course of domestication, but a major riddle remained unsolved: How had the process begun in the first place? As Dugatkin and Trut put it, How had fierce wild animals, intensely averse to human contact, become docile enough for our human ancestors to have started breeding them?

Belyaev had a theory. In his own work, he had noticed that while most foxes were aggressive or agitated around people, a few seemed to have an innate calmness. Perhaps, he speculated, all our ancestors had done was breed the wild wolves that seemed to be the most naturally docile, exhibiting the least fear of and aggression toward humans. And over evolutionary time, as our early ancestors had begun raising them and selecting for this innate tameness, the animals became more and more docile, Dugatkin and Trut write. He thought that all of the other changes involved in domestication had been triggered by this change in the behavioral selection pressure for tameness.

Belyaev decided to test his theory by putting it into action. He would start with wild foxes, breeding the tamest ones he could find over the course of many generations. If he could basically turn a fox into a dog-like animal, he might solve the longstanding riddle of how domestication comes about, the authors write.

The idea wasnt just scientifically bold it was politically risky. Stalins government had banned genetics research in 1948, calling it a bourgeois perversion, and many leading geneticists had been fired, arrested, imprisoned, and even executed. (Belyaevs older brother, a prominent geneticist, was among those killed.) So Belyaev would have to be discreet about the real purpose of his experiment, spinning it as physiological, rather than genetic, research.

In 1958, he recruited Trut, a young animal behaviorist, to run the experiment. She almost immediately began to have doubts about the endeavor. Having had no prior experience with foxes, Lyudmila was taken aback at first by how aggressive they were, Dugatkin and Trut write. Becoming acquainted with these fire-breathing dragons, as she called them, snarling and lunging at her when she approached their cages, she found it hard to believe that they could ever be tamed. Still, she would try. Each morning, she donned a pair of thick gloves and began visiting each fox, carefully observing its reaction as she approached, opened its cage, and slid a stick inside. She selected the calmest foxes, bred them together, and then selected the tamest of the pups to parent the next generation.

It didnt take long for dog-like traits to emerge. By the fourth generation and just the fourth year of the experiment Ember was wagging his tail. By the sixth, about 2 percent of the pups would lick Truts hand, roll over for belly rubs, and cry when their human caretakers walked away. By the following generation, 10 percent of the pups were displaying these behaviors. There seemed to be no doubt at all that these pups, from as early as they could walk, eagerly sought contact with humans, Dugatkin and Trut write. These tame foxes also seemed to have extended puppyhoods, remaining playful and curious well past the age that wild fox pups typically mature. Their bodies changed, too; the tame foxes developed curly tails, floppy ears, and piebald coats.

Maybe it wasnt the foxes underlying genetic code that was changing, but how the genes were regulated or expressed. The idea was wildly ahead of its time.

These new traits had appeared mind-bogglingly fast, over far fewer years and generations than evolution was thought to occur. The speed and nature of the changes led Belyaev to propose a radical theory. Belyaev had realized that most of the changes theyd seen in the foxes involved changes in the timing of when traits turn on and off, Dugatkin and Trut write. Many of the changes they were observing in the tamer foxes involved retaining a juvenile trait longer than normal. The whimpering was a youthful behavior that normally stopped as foxes matured. So was calmness; fox pups are serenely calm when theyre first born, but as they age, foxes typically become quite high-strung. It occurred to Belyaev that maybe it wasnt the foxes underlying genetic code that was changing from one generation to the next, but how the animals genes were regulated or expressed; certain genes that were already present in wild foxes might have become more or less active in the tame ones, or have turned on or off at different stages of development.

The idea was wildly ahead of its time, and it would be decades before research would bear it out. In the meantime, Belyaev and Trut kept breeding foxes. They built their own experimental fox farm in Siberia, and Trut moved into a nearby house with some of the tamest foxes, which quickly adopted behaviors common in pet dogs. (A visiting researcher later demonstrated that the tame foxes had the same high level of social intelligence that dogs did and better social cognition than the wild foxes.) Belyaev died in 1985, but two decades later, researchers finally validated his hypothesis, documenting differences in gene expression between tame and wild or aggressive foxes. (Gene expression isnt the entire story researchers have also found changes in gene sequence in the tame foxes but its clearly an important part of it.)

Dugatkin and Trut deftly synthesize scientific findings from fields ranging from genetics to animal cognition and openly grapple with some provocative unanswered questions: How much further can scientists push these foxes? What do the foxes tell us about the domestication of more distant species, such as cows and pigs? And might they teach us something about our own evolution? (Belyaev proposed that as we organized ourselves into ever-larger social groups, there would have been a selective advantage for individuals who were calm and comfortable around others, rather than aggressive and fearful. Essentially, we are domesticated, but in our case self-domesticated, primates, Dugatkin and Trut write.) The answers to these questions wont come easy, but the experiment is still running; considering what scientists have learned so far, theres no telling what evolutionary insights might emerge if they keep Belyaevs legacy and his line of tame foxes alive for another 60 years.

Emily Anthes, who has written for Undark, The New York Times, The New Yorker, Wired, and Scientific American, among other publications, is the author of Frankensteins Cat: Cuddling Up to Biotechs Brave New Beasts.

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Did That Fox Just Wag Its Tail? Inside a Bold Genetics Experiment - Undark Magazine

‘Genetics’ comment leads to calls for board member’s resignation … – NBC2 News

A member of the Governing Board of the State University apologized after suggesting the reason women make less than men is because of genetics.

But the National Organization for Women says the apology doesnt go far enough.

While discussing the pay gap between men and women graduates, Board of Governors member Ed Morton said: The women are given, maybe some of it is genetic, I dont know. Im not smart enough to know the difference.

A furor followed.

Governor Rick Scott, who appointed Morton, made it clear he didnt agree and released a statement through his press secretary saying, "As a father of two daughters, the Governor absolutely does not agree with this statement."

The following day, Morton apologized in a statement that said in part, I chose my words poorly. My belief is that women and men should be valued equally in the workplace.

The apology isnt enough for the National Organization for Women.

Mr. Morton should resign, said Barbara DeVane, a Lobbyist for Florida NOW.

NOW says if Morton doesnt step down, Rick Scott should remove him from office.

No one in 2017 should ever be making such a statement. Especially someone whos on the Board of Governors, DeVane said.

Florida is one of 15 states that has not ratified the Equal Rights Amendment.

Every session we dont even get a hearing, just like this past session. So for someone in this position to be making such a statement is idiotic and ignorant, she said. Genetics has nothing to do with the difference in salary between a man and a woman. It all has to do with discrimination.

In Florida, women who graduate from state universities are being paid on average $5,500 less each year than men.

Scotts press office failed to issue a statement regarding whether or not the governor would consider removing Morton from office in time for this story.

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'Genetics' comment leads to calls for board member's resignation ... - NBC2 News