Category Archives: Genetics

Hendrix Genetics expand layer distribution in the US – Poultry World (subscription)

Eggs

News Aug 25, 2017259views

Hendrix Genetics has officially opened a new $18.5m hatchery in Nebraska, creating 45 jobs, as it aims to expand its share of the market.

The new layer hatchery has a capacity to produce 24m female chicks per year.

Key contract growers located near the new hatchery will rear and house the birds during production. The company is already working with 8 contract growers in the Grand Island area who have invested in new barns with a capacity of 40,000 birds per barn.

The Grand Island contract growers will complete the new national production hub for Hendrix Genetics in the US, enabling the firm to meet another 10% of the total US layer market needs.

Ron Joerissen, Hendrix Genetics production director layers, said: The new hatchery signifies a major step in supplying the US layer market with top quality laying hens. We are dedicated to breed for the egg producing industry of today and tomorrow.

Nebraskas Governor Pete Ricketts described the plant as a great example of value-added agriculture.

It is not only a $20m investment here that will create between 40 to 50 jobs but it is going to allow area farmers to put up these barns for the eggs that will supply this hatchery and a diversified revenue stream for those farmers who are participating, he said.

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Hendrix Genetics expand layer distribution in the US - Poultry World (subscription)

Trying to Find a Healthy Diet? Look to Your Genes – NBCNews.com

The latest trend in nutrition isn't a fad diet or newly discovered supplement; it's your DNA.

Unlocking the secrets of one's genetic code used to be confined to the laboratory, but increasingly, the big business of DNA is now going after your eating habits. Thanks to new research in a field of study called nutrigenomics, scientists are learning how variations in our genes determine how well our bodies metabolize certain foods and nutrients.

For example, people with a variation of the CYP1A2 gene metabolize caffeine more slowly, and are at an increased risk of heart attack and hypertension if they drink more than a couple of cups of coffee a day.

Companies like the genetic testing service 23andMe helped pave the way for genotyping the process of determining variations in a person's genes to go mainstream. The California-based company has genotyped more than 2 million customers, though their testing focuses on genetic health risks and ancestry reports.

Now, more and more genetics startups are getting into nutrition: looking at how information in your genes could help people decide the best food to eat to feel good and even lose weight.

Scientists from the University of Toronto launched biotechnology company Nutrigenomix in 2012. The company offers genotyping test kits that look at 45 genetic markers related to genes for issues like weight loss, heart health, and food intolerances. The test is designed to help medical professionals make recommendations for a person's intake of sodium, omega-3 fatty acids, vitamin C, and yes, caffeine.

Ahmed El-Sohemy, a professor of nutritional sciences at the University of Toronto and the founder of Nutrigenomix, points to research that shows the "one-size-fits-all model of nutritional guidance" is not the most effective way for people to eat healthily or lose weight.

"There's research now showing that people who get DNA-based dietary advice are more likely to follow recommendations. So not only are people getting more accurate dietary advice, but they are more likely to follow it," said El-Sohemy.

Nutrigenomix uses a saliva test ordered through healthcare professionals, and is available from more than 5,000 healthcare providers in 35 countries.

Now, there's a new kid on the block: Oakland-based personalized nutrition company Habit.

"We think we're going to disrupt the diet industry," Habit founder and CEO Neil Grimmer told NBC News. "When you think about moving from a one-size-fits-all approach to food to something that's highly personalized, it changes everything. It changes the way you shop. It changes the way you eat. And quite frankly, it even changes the way you think about your own health and well-being."

Habit's home testing kit containing DNA cheek swabs, three finger-prick blood tests, and a special shake. The bloodwork is designed to show how your body metabolizes the huge amounts of carbohydrates, fats, and proteins in the shake. Chiara Sottile

At Habit, it's not just DNA data they're using to make diet recommendations. For $299, Habit sends customers an at-home test kit containing DNA cheek swabs, three finger-prick blood tests, and a "metabolic challenge shake loaded with 950 calories. Users take one blood test prior to drinking the shake, and two more timed blood pricks afterwards. The bloodwork is designed to show how your body metabolizes the huge amounts of carbohydrates, fats, and proteins in the shake.

"You layer in your blood work, your fasting blood work, and you layer in your metabolism, and all of a sudden you have a really clear picture of what's going on inside yourself," said Grimmer.

The Habit test kit also asks you to measure your waist circumference and provide information about your weight and activity level. Users send in the DNA swabs and blood sample testing cards sealed in a pre-paid envelope, and then get their results back a couple weeks later.

Health-conscious San Francisco resident Michelle Hillier was introduced to Habit through a friend. When she received her test results, she was surprised to learn she is a diet type Habit calls a "Range Seeker" meaning she should eat about 50 percent of her daily calories in carbohydrates, about 30 percent from fat, and 20 percent from protein.

"You hear so much about how you need so much protein, and I'm a pretty active person so I had been really upping my protein. And to find out that I'm supposed to have more carbs than anything else was really surprising to me," said Hillier, who is not affiliated with the company.

She also learned that she has genes that are impactful for lactose and caffeine sensitivity, something she had suspected. Like all Habit users get for the $299, after she received her test results, Hillier had a 25-minute phone consultation with a registered dietitian from the Habit team.

Michelle Hillier, pictured, learned she is a "Range Seeker," which means she should eat about 50 percent of her daily calories in carbohydrates, about 30 percent from fat, and 20 percent from protein. Chiara Sottile

The Habit test kit is now available nationally (except in New York, New Jersey, and Rhode Island, because of regulatory restrictions). In the San Francisco Bay Area, Habit users get an added perk: the company will cook you fresh meals in their Oakland kitchen based on your diet recommendations and deliver them to your door weekly.

Hillier receives about three dinners a week costing between $10 and $15 a meal and she can choose her meals with Habit's online dashboard.

For Hillier, the Habit meals have been a positive addition to her already healthy lifestyle, though she admits: "The shake was awful," referring to the metabolic challenge shake. "It was like drinking seven coffees, four avocados, and a scoop of ice cream," said Hillier with a laugh.

Blood pricks and a "Challenge Shake" that lives up to its name could be barriers for some people but, Hillier says, it was well worth it for her.

"I've noticed that my clothes are looser on my body, I feel better. I noticed that I have more energy, honestly, since I started doing the meal plans," said Hillier in an interview, noting she's lost about seven pounds since she started receiving the Habit meal plans in May.

Kristin Kirkpatrick is a registered dietitian at the Cleveland Clinic Wellness Institute, where they offer DNA testing kits from Nutrigenomix.

"Many of my patients have mentioned to me that it [nutrigenomics] has truly changed the way that they eat. But I don't think it's the first step. I think seeing a professional and going over what those important goals and barriers are is definitely what you want to do first, said Kirkpatrick in an interview with NBCs Jo Ling Kent.

As some urge potential consumers to do their homework and speak with their own healthcare professional before they take the plunge into their genetics, the market for DNA-based products is racing ahead. Just last month, Helix, a personal genomics company, launched the first online "marketplace."

Customers who have their genome sequenced with Helix get access to a slew of services from other emerging genomics companies ranging from Vinome,which aims to pick wine for you based on your genes, to EverlyWell, which offers food sensitivity and metabolism tests.

"People are very interested to go beyond the generalities that they've seen and get more specific to what's actually impacting their genes," said Kirkpatrick, though she warns this kind of testing "may not be ready for primetime."

The Academy of Nutrition and Dietetics agrees, writing in a 2014 opinion paper that, "...the use of nutrigenetic testing to provide dietary advice is not ready for routine dietetics practice." In the same paper, the Academy did also characterize nutritional genomics as insightful into how diet and genes impact our phenotypes.

"I don't think it's going to answer every single question that you may have about your health and it's definitely not going to answer things that are very specific to health ailments that you may have," Kirkpatrick told NBC News.

"Will it put you in the right direction towards knowing what foods you need to increase? What foods perhaps you should have less of and what's the best source of protein or fat related to weight loss? Absolutely," Kirkpatrick continued.

By 2020, the genomics market is expected to generate a staggering $50 billion globally, and diagnostic tools, health tech, and wireless wearables are expected to boom from $2 billion to $150 billion globally, according to one analysis.

"I think this is the start of a highly personalized future," said Habit CEO Neil Grimmer. "What we really hope to do is actually dispel a lot of the myths, get rid of the fad diets and actually get something that's personal to you."

Michelle Hillier says her Habit "nutrition coach," a registered dietitian, also advised her that she should consider factors beyond just her test results.

"She said take the results with a grain of salt, because you have to first see how you feel when you eat this way. It's not meant to be the 'end all be all,' but it is a guide like anything else," said Hillier.

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Trying to Find a Healthy Diet? Look to Your Genes - NBCNews.com

How white supremacists respond when their DNA says they’re not … – PBS NewsHour

A white supremacist wears a shirt with the slogan European Brotherhood at a rally in Charlottesville, Virginia, U.S., August 12, 2017. Photo by Joshua Roberts/Reuters

Whether youre a white supremacist, a white nationalist or a member of the alt-right, much of your ideology centers around a simple principle: being white. The creation of a white ethnostate, populated and controlled by pure descendants of white Europeans, ranks high on your priority list.

Yet, when confronted with genetic evidence suggesting someone isnt pure blood, as white supremacists put it, they do not cast the person out of online communities. They bargain.

A new study from UCLA found when genetic ancestry tests like 23andMe spot mixed ancestry among white supremacists, most respond in three ways to discount the results and keep members with impure genealogy in their clan. Their reactions range from challenging the basic math behind the tests to accusing Jewish conspirators of sabotage.

Some argued their family history was all the proof they needed. Or they looked in the mirror and clung to the notion that race and ethnicity are directly visible, which is false.

But the real takeaway centers on a new, nuanced pattern within white supremacist groups to redefine and solidify their ranks through genetic ancestry testing, said Aaron Panofsky, a UCLA sociologist who co-led the study presented Monday at the American Sociological Associations 112th annual meeting in Montreal.

Once they start to see that a lot of members of their community are not going to fit the all-white criteria, they start to say, Well, do we have to think about what percentage [of white European genealogy] could define membership? said Aaron Panofsky, a UCLA sociologist who co-led the study presented Monday at the American Sociological Associations 112th annual meeting in Montreal.

And this co-opting of science raises an important reminder: The best way to counter white supremacists may not be to fight their alternative facts with logical ones, according to people who rehabilitate far-right extremists.

To catalog white supremacists reactions to genetic ancestry results, this study logged onto the website Stormfront. Launched in 1995, Stormfront was an original forum of white supremacy views on the internet. The website resembles a Reddit-style social network, filled with chat forums and users posting under anonymous nicknames. By housing nearly one million archived threads and over twelve million posts by 325,000 or more members, Stormfront serves as a living history of the white nationalist movement.

Over the course of two years, Panofsky and fellow UCLA sociologist Joan Donovan combed through this online community and found 153 posts where users volunteered the results of genetic ancestry tests. They then read through the subsequent discussion threads 2,341 posts wherein the community faced their collective identities.

No surprise, but white supremacists celebrate the test results that suggest full European ancestry. One example:

67% British isles18% Balkan15% Scandinavian100% white! HURRAY!

On the flip side, Panofsky and Donovan found that bad news was rarely met with expulsion from the group.

So sometimes, someone says, Yeah, this makes you not white. Go kill yourself,' Panofsky said. Much more of the responses are what we call repair responses where theyre saying, OK, this is bad news. Lets think about how you should interpret this news to make it to make it right.'

These repair responses fell into two categories.

Reject! One coping mechanism involved the outright rejection of genetic tests validity. Some argued their family history was all the proof they needed. Or they looked in the mirror and clung to the notion that race and ethnicity are directly visible, which is false, University of Chicago population geneticist John Novembre told NewsHour.

Genetically, the idea of white European as a single homogenous group does not hold up.

Though the genetics of whiteness are not completely understood, the gene variants known to influence skin color are more diluted across the globe than any random spot in the human genome. That is to say, humans appear, based on our skin pigmentation, to be much more different from each other than we actually are on a genomic level, Novembre said.

Others accused the ancestry companies of being run and manipulated by Jews, in an attempt to thwart white nationalism, but even other Stormfront users pointed out the inaccuracy of this idea.

Reinterpret:The biggest proportion of responses 1,260 posts tried to rationalize the result by offering an educational or scientific explanation for the genetic ancestry results. Many in the online community played a numbers game. If a genetic ancestry test stated someone was 95 percent white European, they would merely count the remaining 5 percent as a statistical error.

Many adapted this line of thinking to make exceptions for those with mixed ancestry. Nearly 500 posts made appeals by misapplying theories of genetics or by saying whiteness is a culture, not just biology an apparent contradiction to the mission of forming a pure ethnostate. This trend led some white supremacists to debate the boundaries of their ethnostate, Panofsky said.

They start to think about the genetic signs and markers of white nationalism that might be useful for our community, Panofsky said. [They say] maybe there are going to be lots of different white nations, each with slightly different rules for nationalism? Or an overlapping set of nations, that are genetically defined in their own ways?

But these arguments are moot, because these genetic ancestry boundaries are inherently built on shaky ground.

If it seems white supremacists are making arbitrary decisions about their ancestry tests, its hard to blame them. Direct-to-consumer ancestry testing is a slippery, secretive industry, built largely upon arbitrary scientific definitions.

Its black box because its corporate, said Jonathan Marks, biological anthropologist at the University of North Carolina at Charlotte. The way these answers are generated depends strongly on the sampling, the laboratory work that you do and the algorithm that you use to analyze the information. All of this stuff is intellectual property. We cant really evaluate it.

White nationalists carry torches on the grounds of the University of Virginia, on the eve of a planned Unite The Right rally in Charlottesville, Virginia, U.S. August 11, 2017. Picture taken August 11, 2017. Photo by Alejandro Alvarez/News2Share via REUTERS

Genetic ancestry companies assess a persons geographic heritage by analyzing DNA markers in their autosomal DNA (for individual variation), mitochondrial DNA (for maternal history) or their Y chromosome (for paternal history). The latter two sources of DNA remain unchanged from parent to child to grandchild, aside from a relatively small number of mutations that occur naturally during life. These mutations can serve as branch points in the trees of human ancestry, Panofsky and Donovan wrote, and as DNA markers specific to different regions around the world.

When genetic anthropologists examine the full scope of humans, they find that historical patterns in DNA markers make the case that everyone in the world came from a common ancestor who was born in East Africa within the last 100,000 to 200,000 years. Plus, groups intermingled so much over the course of history that genetic diversity is a continuum both within American and Europe, through to Asia and Africa, Novembre of the University of Chicago said.

WATCH: Years after transatlantic slavery, DNA tests give clarity

Genetically, the idea of white European as a single homogenous group does not hold up. The classic geographic boundaries of the Mediterranean, Caucasus, and Urals that have shaped human movement and contact are all permeable barriers, said Novembre. Most of the genetic variants you or I carry, we share with other people all across the globeIf you are in some ethnic group, there are not single genetic variants that you definitely have and everyone outside the group does not.

Commercial ancestry companies know these truths, but bend them to draw arbitrary conclusions about peoples ancestry, researchers say. They compare DNA from a customer to the genomes of people or reference groups whose ancestries they claim to already know.

23andMe, for instance, uses reference dataset that include genomes from 10,418 people who were carefully chosen to reflect populations that existed before transcontinental travel and migration were common (at least 500 years ago). To build these geographic groups, they select individuals who say all four of their grandparents were born in the same country, and then remove outliers whose DNA markers do not match well within the group.

These choices willfully bias the genetic definitions for both geography and time. They claim that a relatively small group of modern people can reveal the past makeup of Europe, Africa and Asia and the ancestral histories for millions of customers. But their reference groups skew toward the present and overpromise on the details of where people came from.

While 23andMe denounces the use of their services to justify hateful ideologies, they do not actively ban known white supremacists from their DNA testing.

A study by 23andMe reported that with their definition of European ancestry, there is an average of 98.6 percent European ancestry among self-reported European-Americans. But given all Ive said, we should digest this with caution, Novembre said. An individual with 100 percent European ancestry tests is simply someone who looks very much like the European reference samples being used.

Though ancestry companies cite research that claims genetic tests can pinpoint someone within 100 miles of their European ancestral home, thats not always the case. Marks offered the recent example of three blond triplets who took an ancestry test for the TV show The Doctors. The test said the triplets were 99 percent European. But one sister had more English and Irish ancestry, while another had more French and German. Did we mention they are identical triplets?

That shows you just how much slop there is in these kinds of of ancestry estimates, Marks said.

Marks described commercial ancestry testing as recreational science because its proprietary nature lacks public, academic oversight, but uses scientific practices to validate stereotypical notions of race and ethnicity.

While 23andMe denounces the use of their services to justify hateful ideologies, they do not actively ban known white supremacists from their DNA testing, BuzzFeed reported.

But white supremacists arent the only ones to buy into these wayward notions when genetic ancestry tests support their self-prescribed identities or reject the science when things dont pan out as expected. African-Americans do it too, as Columbia University sociologist Alondra Nelson found in 2008.

Consumers have what I call genealogical aspiration, Nelson told NewsHour. They often make choices among dozens of companies based on the kind of information theyre seeking. If youre interested in finding whether or not youre a member of the small group that has, for example, some trace of Neanderthal DNA, then youre going to go to a company that focuses on that.

She said Panofsky and Donovans study shows that white nationalists will engage in a process of psychic and symbolic negotiation when genetic ancestry results fail to satisfy their impossible idea for racial purity.

But Panofsky, who doesnt support or sympathize with white nationalists, believes these negotiations are not a reason to dismiss white nationalists as ignorant and stupid.

I think that is actually a dangerous view, Panofsky said. Our study reveals that these white nationalists are often engaging with genetic information in extraordinarily sophisticated ways.

Many white supremacists are dealing with toxic shame, a perpetual subconscious belief system where their sense of identity is negative.

White supremacists are trying to deal with the issue of identity as an intellectual problem, said Tony McAleer, the co-founder and board chair of Life After Hate, a counseling organization that rehabs white supremacists. But he said the rehab of white nationalist views doesnt start with challenging their mental gymnastics with data.

We need to deal with the emotional drivers first, McAleer said. University of Maryland did a study of violent extremists and what they found was the number one correlated factor with someone joining a violent extremist group was childhood trauma.

But McAleer continued that the emotional trauma fueling white supremacy extends past physical and sexual abuse. Many white supremacists are dealing with toxic shame, a perpetual subconscious belief system where their sense of identity is negative.

The person feels at a subconscious level theyre not good enough, McAleer said. One way to react to that is to perpetually spend all of your efforts to prove to the world that you are a winner.

So, Life After Hates antidote to this shame is compassion and empathy, he said. Rather than toss statistics about how Muslims arent flooding the country and do not lead to spikes in crime, they will take a white supremacist to an Islamic center and have them sit down and spend time there.

A personal connection is a much more powerful way to change the dynamics within a person, than it is to re-educate the dataset thats in their head, McAleer said.

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How white supremacists respond when their DNA says they're not ... - PBS NewsHour

To Protect Genetic Privacy, Encrypt Your DNA – WIRED

In 2007, DNA pioneer James Watson became the first person to have his entire genome sequencedmaking all of his 6 billion base pairs publicly available for research. Well, almost all of them. He left one spot blank, on the long arm of chromosome 19, where a gene called APOE lives. Certain variations in APOE increase your chances of developing Alzheimers, and Watson wanted to keep that information private.

Except it wasnt. Researchers quickly pointed out you could predict Watsons APOE variant based on signatures in the surrounding DNA. They didnt actually do it, but database managers wasted no time in redacting another two million base pairs surrounding the APOE gene.

This is the dilemma at the heart of precision medicine: It requires people to give up some of their privacy in service of the greater scientific good. To completely eliminate the risk of outing an individual based on their DNA records, youd have to strip it of the same identifying details that make it scientifically useful. But now, computer scientists and mathematicians are working toward an alternative solution. Instead of stripping genomic data, theyre encrypting it.

Gill Bejerano leads a developmental biology lab at Stanford that investigates the genetic roots of human disease. In 2013, when he realized he needed more genomic data, his lab joined Stanford Hospitals Pediatrics Departmentan arduous process that required extensive vetting and training of all his staff and equipment. This is how most institutions solve the privacy perils of data sharing. They limit who can access all the genomes in their possession to a trusted few, and only share obfuscated summary statistics more widely.

So when Bejerano found himself sitting in on a faculty talk given by Dan Boneh, head of the applied cryptography group at Stanford, he was struck with an idea. He scribbled down a mathematical formula for one of the genetic computations he uses often in his work. Afterward, he approached Boneh and showed it to him. Could you compute these outputs without knowing the inputs? he asked. Sure, said Boneh.

Last week, Bejerano and Boneh published a paper in Science that did just that. Using a cryptographic genome cloaking method, the scientists were able to do things like identify responsible mutations in groups of patients with rare diseases and compare groups of patients at two medical centers to find shared mutations associated with shared symptoms, all while keeping 97 percent of each participants unique genetic information completely hidden. They accomplished this by converting variations in each genome into a linear series of values. That allowed them to conduct any analyses they needed while only revealing genes relevant to that particular investigation.

Just like programs have bugs, people have bugs, says Bejerano. Finding disease-causing genetic traits is a lot like spotting flaws in computer code. You have to compare code that works to code that doesnt. But genetic data is much more sensitive, and people (rightly) worry that it might be used against them by insurers, or even stolen by hackers. If a patient held the cryptographic key to their data, they could get a valuable medical diagnosis while not exposing the rest of their genome to outside threats. You can make rules about not discriminating on the basis of genetics, or you can provide technology where you cant discriminate against people even if you wanted to, says Bejerano. Thats a much stronger statement.

The National Institutes of Health have been working toward such a technology since reidentification researchers first began connecting the dots in anonymous genomics data. In 2010, the agency founded a national center for Integrating Data for Analysis, Anonymization and Sharing housed on the campus of UC San Diego. And since 2015, iDash has been funding annual competitions to develop privacy-preserving genomics protocols. Another promising approach iDash has supported is something called fully homomorphic encryption, which allows users to run any computation they want on totally encrypted data without losing years of computing time.

Kristen Lauter, head of cryptography research at Microsoft, focuses on this form of encryption, and her team has taken home the iDash prize two years running. Critically, the method encodes the data in such a way that scientists dont lose the flexibility to perform medically useful genetic tests. Unlike previous encryption schemes, Lauters tool preserves the underlying mathematical structure of the data. That allows computers to do the math that delivers genetic diagnoses, for example, on totally encrypted data. Scientists get a key to decode the final results, but they never see the source.

This is extra important as more and more genetic data moves off local servers and into the cloud. The NIH lets users download human genomic data from its repositories, and in 2014, the agency started letting people store and analyze that data in private or commercial cloud environments. But under NIHs policy, its the scientists using the datanot the cloud service providerresponsible with ensuring its security. Cloud providers can get hacked, or subpoenaed by law enforcement, something researchers have no control over. That is, unless theres a viable encryption for data stored in the cloud.

If we dont think about it now, in five to 10 years a lot peoples genomic information will be used in ways they did not intend, says Lauter. But encryption is a funny technology to work with, she says. One that requires building trust between researchers and consumers. You can propose any crazy encryption you want and say its secure. Why should anyone believe you?

Thats where federal review comes in. In July, Lauters group, along with researchers from IBM and academic institutions around the world launched a process to standardize homomorphic encryption protocols. The National Institute for Standards and Technology will now begin reviewing draft standards and collecting public comments. If all goes well, genomics researchers and privacy advocates might finally have something they can agree on.

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To Protect Genetic Privacy, Encrypt Your DNA - WIRED

YHS Teacher Attends Genetics Workshop – Yankton Daily Press

Sanford Health and Harvard Medical School have collaborated to bring information and education about personal genetics and research to classrooms and communities in Massachusetts and South Dakota.

One such program the two facilities have created is the Personal Genetics Education Project (pgEd), which offers workshops that bring awareness and create community understanding about development in genetics and how they affect health.

Lindsay Kortan, who teaches ninth-grade physical science at Yankton High School (YHS), jumped at the chance to learn more about genetics by attending the pgEd Genetics and Social Justice Summer Institute in Brockton, Massachusetts this summer.

A member of the South Dakota Science Teachers Association, Kortan is also a Sanford ambassador and has done research with the organization for several years. It was through this involvement that she was invited to attend the weeklong pgEd conference.

"The setup was them showing (the attendees) their lesson plans, allowing us to experience what type of content is in the lesson and what kind of discussions/questions we might have in the classroom," she explained. "It covered a wide range of things, everything from the eugenics movement to ethics in genetics testing to personal genetics testing."

As someone who developed a strong interest in genetics through her studies at the University of South Dakota, all of this was right up Kortans alley.

"(Genetics) was one of my favorite topics to teach in a biology classroom," she said.

Prior to coming to YHS, Kortan had taught grades 10-12 science biology, physiology, physics and chemistry in the Bon Homme school district for five years.

She admitted that introducing what she learned at the conference into her current class will be difficult, but plans to spread her newfound information in other ways.

"Ive shared my knowledge with some of the other teachers and offered to help them incorporate it into their classrooms if theyre interested," she said.

She plans to be part of next summers workshop in Sioux Falls, which will be hosted by Sanford PROMISE and pgEd.

"From an education perspective, the pgED information is great for teaching our kids those critical-thinking and difficult life-decision questions they might have to encounter in their lifetime, especially now with the way genetic testing and technology is advancing," she said. "Its getting more prevalent in making decisions, even down to doctors looking at your genetic code to know what drugs they should prescribe to you, or whether the drug will be effective or not. Its important for kids to know that information before they get into those critical situations where they have to make an (important) decision. The process of going through that critical thinking and seeing different viewpoints is always a good thing in the classroom.

"Im currently pregnant, so some of those genetic questions that you get asked because of pregnancy and fertility treatments (that) I received really brought it to a personal level for me."

Follow @ReillyBiel on Twitter.

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YHS Teacher Attends Genetics Workshop - Yankton Daily Press

Study reveals white nationalists’ reactions when genetics test results challenge their identity – UCLA Newsroom

A new study by UCLA researchers reveals the range of reactions from rejection to reinterpretation to acceptance after white nationalists learn that DNA ancestry test results indicate they may not be as white or European as they previously thought.

Thestudy,When Genetics Challenges a Racists Identity: Genetic Ancestry Testing Among White Nationalists, is the work of UCLA researchersAaron Panofskyand Joan Donovan, who presented their findings at the annual meeting of the American Sociological Association held Aug. 14, 2017, in Montreal, Canada.

Upon receiving genetic evidence of non-white or non-European ancestry, those posting online expend considerable energy to repair identities by rejecting or reinterpreting genetic ancestry testing results, said the researchers, who studied discussion threads on the topic posted on the white nationalist online forum Stormfront.

UCLA Luskin School of Public Affairs

Aaron Panofsky

In their study, Donovan and Panofsky, an associate professor with appointments in Public Policy at UCLA Luskin School of Public Affairs, the Institute for Society and Genetics, and Sociology, looked at more than 3,000 posts in 70 discussion threads on topics related to test reveals. These included posts by individuals who revealed results of non-white/non-European ancestry on Stormfront, a website that requires members to be white or European with non-Jewish ancestry. Responses also included the comments on those test results.

Panofsky and Donovan, a postdoctoral fellow at the Institute for Society and Genetics, report that while ancestry tests promote the capacity to reveal ones genetic ties to ethnic groups, ancient populations and historical migrations, and even famous historical figures this opportunity to know thyself can come with significant risks.

Panofsky points out that based on white nationalists responses to genetic information upon learning their test results, there is no reason to believe that they would give up their racial ideology, and, more importantly, that genetic information cannot be relied on to change the views of white nationalists.

In addition, Panofsky said that, as a group, white nationalists appear to have a combination of sophisticated and unsophisticated methods of interpreting the data from statistical and genetic viewpoints, as well as on their own historical reasoning or reinterpretation.

In this framework, the repair strategy is not to reject scientific or historical knowledge, but to educate oneself to understand the construction of [genetic test] results and to explain those results in alternate terms, the researchers conclude.

In parsing responses to genetic ancestry test results posted on Stormfront, Panofsky and Donovan created a decision tree consisting of good news responses, or confirmation of white identity, or bad news, revealing results of non-white or non-European ancestry.

Good news served a confirming purpose and was well-received, but bad news elicited responses of rejection of the test results. Alternatives to the rejected responses included championing traditional methods, citing family history or using a mirror test, whereby individuals evaluated their outward appearance as a gauge of racial identity.

Many of the responses to bad news are about how to repair the damage, rather than latching onto the ideology of Stormfront, Panofsky said. Even though they have that idea of purity, they help people explain away or dismiss the result.

The researchers also found that some who reject unfavorable genetic test results interpret them as the product of companies with an anti-white bias, or Jewish ownership invested in sowing racial doubt and confusion among whites. They also attribute a small percentage of non-white or non-European markers as being part of a multicultural conspiracy, according to the study.

Another way the posters dealt with bad news, Panofsky and Donovan reported, was to discount indications of non-white ancestry as a statistical error or noise to engage in scientific reinterpretation of the results.

The findings also indicate that white nationalists are using genetic ancestry test results to rethink the boundaries of whiteness. Panofsky and Donovan point out that a great deal of discussion on Stormfront focuses on what are the genetic markers of legitimate whiteness or European-ness, and how to think about white nationalism in an era of genetic ancestry testing.

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Study reveals white nationalists' reactions when genetics test results challenge their identity - UCLA Newsroom

DNA Kit Uses Genetics for Customized Skin Care Regimen – WWD

Virgil Abloh and Nike announce new design project "The 10," where the Off-White designer reconstructs ten iconic Nike models. During NYFW, Nike will introduce a space in partnership with Abloh to celebrate their collab. Get all the details and see what other initiatives Nike is pursuing during fashion week on WWD.com. #wwdfashion

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DNA Kit Uses Genetics for Customized Skin Care Regimen - WWD

Most Breast-Ovarian Ca Patients Miss Genetic Tests – MedPage Today

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Despite the existence of evidence-based guidelines supporting genetic testing for women with a history of breast and/or ovarian cancer, most of these women didn't get tested, according to researchers.

Based on an analysis of pooled data from three cancer control modules, fewer than one in five women with a history of breast or ovarian cancer meeting National Cancer Comprehensive Network (NCCN) criteria underwent testing, reported Christopher P. Childers, MD, of the David Geffen School of Medicine at UCLA in Los Angeles, and colleagues.

Up to 10% of breast and 15% of ovarian cancers can be linked to heritable gene mutations -- most commonly mutations in the BRCA1 and BRCA2 -- which suggests that the identification of women with these mutations can direct both cancer treatment and surgical decision-making, they wrote in the Journal of Clinical Oncology.

While the rates of genetic testing in newly diagnosed patients meeting NCCN criteria have been increasing, "there is likely a large cohort of breast and ovarian cancer survivors for whom testing was not offered, pursued, or even available," Childers' group wrote.

They used nationally representative samples from the 2005, 2010, and 2015 National Health Interview Surveys (NHIS). Eligible patients included women with a history of breast cancer and/or ovarian cancer who met certain NCCN eligibility criteria based on age of diagnosis and family history:

Outcomes included the percentage of eligible individuals who either discussed genetic testing with a health professional, were advised to undergo such testing, or actually underwent testing.

Of 47,218 women identified from the three surveys, 2.7% had breast cancer. Of those women, about 36% met one or more of the eligibility criteria, and of those, 29% discussed testing with a healthcare professional, 20.2% were advised to undergo testing, and 15.3% underwent testing.

Approximately 0.4% of the women in the survey had ovarian cancer. Of those, 15.1% discussed testing, 13.1% percent were advised to undergo testing, and just 10.5% underwent testing.

Based on the pooled sample, an estimated 1,471,279 women with a history of breast and/or ovarian cancer meet one or more of the eligibility criteria. The authors determined that within this population, the rate of genetic testing was 13.8% (95% CI 10.8% to 17%).

"Using only these five criteria, this generates a population-based estimate of unmet need of genetic testing for breast and ovarian cancer survivors between 1,212,334 and 1,312,381," they noted.

Furthermore over 70% of eligible patients with breast cancer and 80% of those with ovarian cancer haven't even discussed genetic testing with a health professional.

"Given the low testing rate and large impact of identifying a heritable mutation, aggressive solutions should be considered," Childers' group suggested. "These may include universal testing for women with breast and/or ovarian cancer or other select populations, directed patient education for self-referral, or modified direct-to-consumer testing."

The study had some limitations, including the fact that NHIS collects self-reported data only, and is not validated against the medical record. Also, recall bias in terms of "advising, discussing, and testing are all possible and are likely magnied as patients become more removed from their treatment," the authors noted.

In an accompanying editorial, Kevin S. Hughes, MD, of the Avon Comprehensive Breast Evaluation Center at Massachusetts General Hospital in Boston, lamented that while many new strategies involving genetic testing have been adopted and save lives, "we have yet to apply these strategies at the population level where their effect can be generalized beyond a small number of selected patients."

Hughes wrote that while some reports of the underutilization of genetic testing have been met by calls for more genetic counselors, "there is nowhere near the number of genetic counselors needed to take on population-level testing."

The problem is that too many mutation carriers are unaware of their status and could develop cancers that could have been prevented or discovered earlier, he stated, adding that healthcare professionals need to take certain steps that will increase the rate of detection of these mutations.

He suggested some steps that can be taken, such as abbreviating pretest counseling sessions to enable more patients to be seen by genetic counselors or educated clinics. "It is time to move to population-level screening for hereditary cancer susceptibility mutations. We have thought about this for 20 years. It might be time to take action," he wrote.

Childers disclosed funded from the Agency for Healthcare Research and Quality.

Childers and co-authors disclosed no relevant relationships with industry.

Hughes disclosed relevant relationships with Hughes RiskApps, CRA Health, Myriad Genetics, Veritas Genetics, Focal Therapeutics, and Health Beacons.

2017-08-23T12:00:00-0400

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Most Breast-Ovarian Ca Patients Miss Genetic Tests - MedPage Today

Using Genetics to Uncover Human History – JD Supra (press release)

Human history is often something modern man only sees as through a glass, darkly. This is particularly the case when that history did not occur in the Mediterranean, the Nile Valley, India, or China, or when there is no written record on which scholars can rely. Exacerbating the disrupting effects of time on history can be when that history occurs in a region where extensive migration has disrupted whatever temporarily stable civilization happened to have taken root at that place at any particular time.

But humans leave traces of themselves in their history and a variety of such traces have been the source of reconstructions outside conventional sources. Luigi Cavalli-Sforza began the study of human population genetics as a way to understand this history in 1971 in The Genetics of Human Populations, and later extended these studies to include language and how it influences gene flow between human populations. More recent efforts to use genetics to reconstruct history include Deep Ancestry: The Landmark DNA Quest to Decipher Our Distant Past by Spencer Wells (National Geographic: 2006), and The Seven Daughters of Eve: The Science that Reveals our Genetic Ancestry by Brian Sykes (Carrol & Graf: 2002). And even more recently, genetic studies have illuminated the "fine structure" of human populations in England (see "Fine-structure Genetic Mapping of Human Population in Britain").

Two recent reports illustrate how genetics can inform history: the first, in the American Journal of Human Genetics entitled "Continuity and Admixture in the Last Five Millennia of Levantine History from Ancient Canaanite and Present-Day Lebanese Genome Sequences"; and a second in the Proceedings of the National Academy of Sciences USA, entitled "Genomic landscape of human diversity across Madagascar." In the first study, authors* from The Wellcome Trust Sanger Institute, University of Cambridge, University of Zurich, University of Otago, Bournemouth University, Lebanese American University, and Harvard University found evidence of genetic admixture over 5,000 years of a Canaanite population that has persisted in Lebanese populations into the modern era. This population is interesting for historians in view of the central location of the ancestral home of the Canaanites, the Levant, in the Fertile Crescent that ran from Egypt through Mesopotamia. The Canaanites also inhabited the Levant during the Bronze Age and provide a critical link between the Neolithic transition from hunter gatherer societies to agriculture. This group (known to the ancient Greeks as the Phoenicians) is also a link to the great early societies recognized through their historical writings and civilizations (including the Egyptians, Assyrians, Babylonians, Persians, Greeks, and Romans); if the Canaanites had any such texts or other writings they have not survived. In addition, the type of genetic analyses that have been done for European populations has not been done for descendants of inhabitants of the Levant from this historical period. This paper uses genetic comparisons between 99 modern day residents of Lebanon (specifically, from Sidon and the Lebanese interior) and ancient DNA (aDNA) from ~3,700 year old genomes from petrous bone of individuals interred in gravesites in Sidon. For aDNA, these analyses yielded 0.4-2.3-fold genomic DNA coverage and 53-264-fold mitochondrial DNA coverage, and also compared Y chromosome sequences with present-day Lebanese, two Canaanite males and samples from the 1000 Genomes Project. Over one million single nucleotide polymorphisms (SNPs) were used for comparison.

These results indicated that the Canaanite ancestry was an admixture of local Neolithic populations and migrants from Chalcolithic (Copper Age) Iran. The authors estimate from these linkage disequilibrium studies that this admixture occurred between 6,600 and 3,550 years ago, a date that is consistent with recorded mass migrations in the region during that time. Perhaps surprisingly, their results also show that the majority of the present-day Lebanese population has inherited most of their genomic DNA from these Canaanite ancestors. These researchers also found traces of Eurasian ancestry consistent with conquests by outside populations during the period from 3,750-2,170 years ago, as well as the expansion of Phoenician maritime trade network that extended during historical time to the Iberian Peninsula.

The second paper arose from genetic studies of an Asian/African admixture population on Mozambique. This group** from the University of Toulouse, INSERM, the University of Bordeaux, University of Indonesia, the Max Plank Institute for Evolutionary Anthropology, Institut genomique, Centre Nacional de Genotypage, University of Melbourne, and the Universite de la Rochelle, showed geographic stratification between ancestral African (mostly Bantu) and Asian (Austronesean) ancestors. Cultural, historical, linguistic, ethnographic, archeological, and genetic studies supports the conclusion that Madagascar residents have traits from both populations but the effects of settlement history are termed "contentious" by these authors. Various competing putative "founder" populations (including Arabic, Indian, Papuan, and/or Jewish populations as well as first settlers found only in legend, under names like "Vazimba," "Kimosy," and "Gola") have been posited as initial settlers. These researchers report an attempt to illuminate the ancestry of the Malagasy by a study of human genetics.

These results showed common Bantu and Austronesian descent for the population with what the authors termed "limited" paternal contributions from Europe and Middle Eastern populations. The admixture of African and Austronesian populations occurred "recently" (i.e., over the past millennium) but was gender-biased and heterogeneous, which reflected for these researchers independent colonization by the two groups. The results also indicated that detectable genetic structure can be imposed on human populations over a relatively brief time (~ a few centuries).

Using a "grid-based approach" the researchers performed a high-resolution genetic diversity study that included maternal and paternal lineages as well as genome-wide data from 257 villages and over 2,700 Malagasy individuals. Maternal inheritance patterns were interrogated using mitochondrial DNA and patterns of paternity assayed using Y chromosomal sequences. Non-gender specific relationships were assessed through 2.5 million SNPs. Mitochondrial DNA analyses showed maternal inheritance from either African or East Asian origins (with one unique Madagascar variant termed M23) in roughly equal amounts, with no evidence of maternal gene flow from Europe or the Middle East. The M23 variant shows evidence of recent (within 900-1500 years) origin. Y chromosomal sequences, in contrast are much more prevalent from African origins (70.7% Africa:20.7% East Asia); the authors hypothesize that the remainder may reflect Muslim influences, with evidence of but little European ancestry.

Admixture assessments support Southeast Asian (Indonesian) and East African source populations for the Malagasy admixture. These results provide the frequency of the African component to be ~59%, the Asian component frequency to be ~37%, and the Western European component to have a frequency of about 4% (albeit with considerable variation, e.g., African ancestry can range from ~26% to almost 93%). Similar results were obtained when the frequency of chromosomal fragments shared with other populations were compared to the Malagasy population (finding the closest link to Asian populations from south Borneo, and excluding Indian, Somali, and Ethiopian populations, although the analysis was sensitive in one individual to detect French Basque ancestry). The split with ancestral Asian populations either occurred ~2,500 years ago or by slower divergence between ~2,000-3,000 years ago, while divergence with Bantu populations occurred more recently (~1,500 years ago).

There were also significant differences in geographic distribution between descendants of these ancestral populations. Maternal African lineages were found predominantly in north Madagascar, with material Asian lineages found in central and southern Madagascar (from mtDNA analyses). Paternal lineages were generally much lower overall for Asian descendants (~30% in central Madagascar) based on Y chromosome analyses. Genome-wide analyses showed "highlanders" had predominantly Asian ancestry (~65%) while coastal inhabitants had predominantly (~65%) African ancestry; these results depended greatly on the method of performing the analyses which affected the granularity of the geographic correlates. Finally, assessing admixture patterns indicated that the genetic results are consistent with single intermixing event (500-900 years ago) for all but one geographic area, which may have seen a first event 28 generations ago and a second one only 4 generations ago. These researchers also found evidence of at least one population bottleneck, where the number of individuals dropped to a few hundred people about 1,000-800 years ago.

These results are represented pictorially in the paper:

In view of the current political climate, the eloquent opening of the paper deserves attention:

Ancient long-distance voyaging between continents stimulates the imagination, raises questions about the circumstances surrounding such voyages, and reminds us that globalization is not a recent phenomenon. Moreover, populations which thereby come into contact can exchange genes, goods, ideas and technologies.

* Marc Haber, Claude Doumet-Serhal, Christiana Scheib, Yali Xue, Petr Danecek, Massimo Mezzavilla, Sonia Youhanna, Rui Martiniano, Javier Prado-Martinez, Micha Szpak, Elizabeth Matisoo-Smith, Holger Schutkowski, Richard Mikulski, Pierre Zalloua, Toomas Kivisild, Chris Tyler-Smith

** Denis Pierrona, Margit Heiskea, Harilanto Razafindrazakaa, Ignace Rakotob, Nelly Rabetokotanyb, Bodo Ravololomangab, Lucien M.-A. Rakotozafyb, Mireille Mialy Rakotomalalab, Michel Razafiarivonyb, Bako Rasoarifetrab, Miakabola Andriamampianina Raharijesyb, Lolona Razafindralambob, Ramilisoninab, Fulgence Fanonyb, Sendra Lejamblec, Olivier Thomasc, Ahmed Mohamed Abdallahc, Christophe Rocherc,, Amal Arachichec, Laure Tonasoa, Veronica Pereda-lotha, Stphanie Schiavinatoa, Nicolas Brucatoa, Francois-Xavier Ricauta, Pradiptajati Kusumaa,d,e, Herawati Sudoyod,e, Shengyu Nif, Anne Bolandg, Jean-Francois Deleuzeg, Philippe Beaujardh, Philippe Grangei, Sander Adelaarj, Mark Stonekingf, Jean-Aim Rakotoarisoab, Chantal Radimilahy, and Thierry Letelliera

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Using Genetics to Uncover Human History - JD Supra (press release)

UCLA Researchers Study Reveals White Nationalists’ Reactions When Genetics Test Results Challenge Their Identity – Sierra Sun Times

August 23, 2017 - By Stan Paul - A new study by UCLA researchers reveals the range of reactions from rejection to reinterpretation to acceptance after white nationalists learn that DNA ancestry test results indicate they may not be as white or European as they previously thought.

Thestudy,When Genetics Challenges a Racists Identity: Genetic Ancestry Testing Among White Nationalists, is the work of UCLA researchersAaron Panofskyand Joan Donovan, who presented their findings at the annual meeting of the American Sociological Association held Aug. 14, 2017, in Montreal, Canada.

Upon receiving genetic evidence of non-white or non-European ancestry, those posting online expend considerable energy to repair identities by rejecting or reinterpreting genetic ancestry testing results, said the researchers, who studied discussion threads on the topic posted on the white nationalist online forum Stormfront.

(Right) Aaron Panofsky - Credit: UCLA Luskin School of Public Affairs

In their study, Donovan and Panofsky, an associate professor with appointments in Public Policy at UCLA Luskin School of Public Affairs, the Institute for Society and Genetics, and Sociology, looked at more than 3,000 posts in 70 discussion threads on topics related to test reveals. These included posts by individuals who revealed results of non-white/non-European ancestry on Stormfront, a website that requires members to be white or European with non-Jewish ancestry. Responses also included the comments on those test results.

Panofsky and Donovan, a postdoctoral fellow at the Institute for Society and Genetics, report that while ancestry tests promote the capacity to reveal ones genetic ties to ethnic groups, ancient populations and historical migrations, and even famous historical figures this opportunity to know thyself can come with significant risks.

Panofsky points out that based on white nationalists responses to genetic information upon learning their test results, there is no reason to believe that they would give up their racial ideology, and, more importantly, that genetic information cannot be relied on to change the views of white nationalists.

In addition, Panofsky said that, as a group, white nationalists appear to have a combination of sophisticated and unsophisticated methods of interpreting the data from statistical and genetic viewpoints, as well as on their own historical reasoning or reinterpretation.

In this framework, the repair strategy is not to reject scientific or historical knowledge, but to educate oneself to understand the construction of [genetic test] results and to explain those results in alternate terms, the researchers conclude.

In parsing responses to genetic ancestry test results posted on Stormfront, Panofsky and Donovan created a decision tree consisting of good news responses, or confirmation of white identity, or bad news, revealing results of non-white or non-European ancestry.

Good news served a confirming purpose and was well-received, but bad news elicited responses of rejection of the test results. Alternatives to the rejected responses included championing traditional methods, citing family history or using a mirror test, whereby individuals evaluated their outward appearance as a gauge of racial identity.

Many of the responses to bad news are about how to repair the damage, rather than latching onto the ideology of Stormfront, Panofsky said. Even though they have that idea of purity, they help people explain away or dismiss the result.

The researchers also found that some who reject unfavorable genetic test results interpret them as the product of companies with an anti-white bias, or Jewish ownership invested in sowing racial doubt and confusion among whites. They also attribute a small percentage of non-white or non-European markers as being part of a multicultural conspiracy, according to the study.

Another way the posters dealt with bad news, Panofsky and Donovan reported, was to discount indications of non-white ancestry as a statistical error or noise to engage in scientific reinterpretation of the results.

The findings also indicate that white nationalists are using genetic ancestry test results to rethink the boundaries of whiteness. Panofsky and Donovan point out that a great deal of discussion on Stormfront focuses on what are the genetic markers of legitimate whiteness or European-ness, and how to think about white nationalism in an era of genetic ancestry testing.Source: UCLA

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UCLA Researchers Study Reveals White Nationalists' Reactions When Genetics Test Results Challenge Their Identity - Sierra Sun Times