Hank and his brother John discuss heredity via the gross example of relative ear wax moistness.

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tags: crashcourse, science, biology, evolution, genetics, heredity, aristotle, bloodlines, gregor mendel, mendelian genetics, mendelian trait, classical genetics, chromosome, gene, polygenic, pleiotropic, allele, ear wax gene, somatic, diploid, gametes, sperm, egg, haploid, polyploid, dominance, dominant, recessive, heterozygous, homozygous, phenotype, punnett square, reginald c. punnett, sex-linked inheritance, autosome Support CrashCourse on Subbable: http://subbable.com/crashcourse

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Heredity: Crash Course Biology #9

CYP1A1*2C A4889Grs1048943CTT-/-CYP1A1*4 C2453Ars1799814TGG-/-CYP1A2 C164Ars762551CAC+/-CYP1B1 L432Vrs1056836CCG+/-CYP1B1 N453Srs1800440CTT-/-CYP1B1 R48Grs10012CGG-/-CYP2A6*2 A1799Trs1801272TAA-/-CYP2C19*17rs12248560TCC-/-CYP2C9*2 C430Trs1799853TCC-/-CYP2C9*3 A1075Crs1057910CAA-/-CYP2D6 S486Trs1135840GGG+/+CYP2D6 T100Crs1065852AGG-/-CYP2D6 T2850Crs16947AAA+/+CYP2E1*1B G9896Crs2070676GCC-/-CYP2E1*4 A4768Grs6413419AGG-/-CYP3A4*1Brs2740574CTT-/-CYP3A4*3 M445Trs4986910GAA-/-CYPs are primarily membrane-associatedproteins located either in the inner membrane ofmitochondriaor in theendoplasmic reticulumof cells. CYPs metabolize thousands ofendogenousandexogenouschemicals. Some CYPs metabolize only one (or a very few) substrates, such asCYP19(aromatase), while others may metabolize multiple substrates. Both of these characteristics account for their central importance inmedicine. Cytochrome P450 enzymes are present in most tissues of the body, and play important roles inhormonesynthesis and breakdown includingestrogenandtestosteronesynthesis and metabolism,cholesterolsynthesis, andvitamin Dmetabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, includingdrugsand products of endogenous metabolism such asbilirubin, principally in theliver.rs762551 (C) allele is a slow metabolizer or of certain substrates including caffeine which means Im more stimulated by it than most people.rs1056836 increases susceptibility to lung and breast cancer, blocks testosterone and inhibits mitochondrial function.rs1135840 is involved in the metabolism of approximately 25% of all medications and most psych meds including antipsychotics and antidepressants.GPX3rs8177412CTT-/-GSTM1rs12068997TCC-/-GSTM1rs4147565AGG-/-GSTM1rs4147567GAA-/-GSTM1rs4147568ATT-/-GSTM1rs1056806TCC-/-GSTM1rs12562055ATT-/-GSTM1rs2239892GAA-/-GSTP I105Vrs1695GAG+/-GSTP1 A114Vrs1138272TCC-/-GSTP genes encode the Glutathione S-transferase P enzyme. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of manyhydrophobic and electrophilic compounds with reducedglutathione. Mutations here will increase your need for glutathione and importance of chelating out mercury.rs1695 influences asthma risk.NAT1 A560G(?) (R187Q)rs4986782AGG-/-NAT2 A803G (K268R)rs1208GGG+/+NAT2 C190T (R64W)rs1805158TCC-/-NAT2 G590A (R197Q)rs1799930AGG-/-NAT2 G857A (G286E)rs1799931AGG-/-NAT2 T341C (I114T)rs1801280CCC+/+NAT2 encodes N-acetyltransferases which are enzymes acting primarily in the liver to detoxify a large number of chemicals, includingcaffeineand several prescribed drugs. The NAT2 acetylation polymorphism is important because of its primary role in the activation and/or deactivation of many chemicals in the bodys environment, including those produced by cigarettes as well as aromatic amine and hydrazine drugs used medicinally. In turn, this can affect an individualscancerrisk.I have a particular combination of NAT2 polymorphisms rs1801280 (C) +rs1208 (G) which makes me a slow metabolizer. In general, slow metabolizers have higher rates of certain types ofcancerand are more susceptible to side effects from chemicals (known as MCS) metabolized by NAT2.SOD2rs2758331AAA+/+SOD2rs2855262TCT+/-SOD2 A16Vrs4880GGG+/+SOD2 gene is a member of the iron/manganesesuperoxide dismutasefamily and may be one of the key sources of my troubles. This protein transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain, intohydrogen peroxideand diatomicoxygen. In simpler terms, the more energy your mitochondria produce, the more byproducts (also called free radicals) get produced. These toxic byproducts tear up cell membranes and walls through a process called oxidative stress.Mutations in the SOD2 gene diminish your ability to transform these toxic byproducts into harmless components. People with SOD2 polymorphisms may not tolerate nitrates or fish oil well. Mutations in this gene have been associated withidiopathic cardiomyopathy(IDC), sporadic motor neuron disease, and cancer.

Now what about SOD1 & 3? I dont know why it doesnt appear on this report but I was able to get some information on it from Livewello and it looks like I am much better off there. Heres my SOD1 and SOD3 status. Just for kicks, I decided to run SOD2 and I find it shows a much different picture than sterlings app: my SOD 2 on Livewello. Notice how it shows that I do have some working SOD2 genes!

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My genetics - How I Recovered

1 : relating to or determined by the origin, development, or causal antecedents of something

2a : of, relating to, or involving genetics

b : of, relating to, caused by, or controlled by genes a genetic disease genetic variation

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Genetic | Definition of Genetic by Merriam-Webster

Genetics is the study of how traits and diseases pass from parents to children. Many conditions are passed from parents to children, including some birth defects and developmental disabilities. Seattle Children's has one of the largest programs in the United States devoted to genetics research and care for children with genetic conditions. We are home to the oldest and most well-known referral center for genetic disorders in the Pacific Northwest.

Because conditions related to genetics are so wide-ranging, our doctors come from many backgrounds and medical specialties, including human and medical genetics,neurology, developmental and behavioral pediatrics, developmental biology and biochemistry. At Seattle Children's Genetics program, a team made up of experts in their fields, including surgeons, therapists and social workers, will see your child and work with you to understand any genetic conditions your child may have.

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Genetics - seattlechildrens.org

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DNA Genetics

For other uses, see Transition. Illustration of a transition: each of the 4 nucleotide changes between purines or between pyrimidines (in blue). The 8 other changes are transversions (in red).

Transition, in genetics and molecular biology, refers to a point mutation that changes a purine nucleotide to another purine (A G), or a pyrimidine nucleotide to another pyrimidine (C T). Approximately two out of three single nucleotide polymorphisms (SNPs) are transitions.[1]

Transitions can be caused by oxidative deamination and tautomerization.[2] Although there are twice as many possible transversions, transitions appear more often in genomes, possibly due to the molecular mechanisms that generate them.[3]

5-Methylcytosine is more prone to transition than unmethylated cytosine, due to spontaneous deamination. This mechanism is important because it dictates the rarity of CpG islands.

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Transition (genetics) - Wikipedia

# Genetics And Diabetes # Pre Diabetes Webmd Diabetic Diet Plan To Gain Weight The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days.[ GENETICS AND DIABETES ] The REAL cause of Diabetes ( Recommended ),Genetics And Diabetes Gestational diabetes is just another aspect of diabetes with a twist. It happens during pregnancy when blood sugar levels increase and everyone should know that is actually because the time that is vital to eat well in deliver will be desired way so having blood sugar level levels will be irregular are certainly not extremely. Genetics And Diabetes Diabetes is often a serious illness which destroys the body. There is a poison inside the bloodstream leads to the parts of the body to lack the possibility. This illness is painful and intensely strong. Many lose the uses with their legs providing to hold the legs away. This is brought on by the poison glucose in the bloodstream that is out of control. This poison blood glucose spreads on the eyes and results blurry vision and for most blindness. It is critical get rid of this accelerated. When seeking to new diabetes medicine without medication should turn to your diet. Basically healing diet can save the body. Genetics And Diabetes Like I discussed earlier it is incurable for diabetes right. The sole cure is employing great and bad food exercise as well as other resources that can help you reverse diabetes.,Genetics And Diabetes Eating smaller portions of meals is not really a superb way of chance of heart disease but in the same time that it is the most beneficial technique of controlling the degrees of blood. It is for you to control the portion genuine salad plate or smaller plate. Every person better to stay away from snacking during cooking. Never try to the left over food to avoid it from throwing or storing in refrigerator. Breakfast is probably the most important meal of the day. Carefully select the meal plan for breakfast. Eat the meals and snacks at fixed times daily. Genetics And Diabetes Did you will know treating Diabetes is now a $132-billion per year business.Unfortunately far too often profits are usually put prior to a patients. (Marcia Angell Mirielle.D. Editor of the New England Journal of Medicine). It really is change this. I believe that it might be worth exploring healthier more natural methods of controlling our Diabetes than using harmful drugs yourself. I can share a good source along with you that addresses this drawback. Genetics And Diabetes If the already diagnosed with diabetes should consider that there are specific foods essential you not to take. That not to forget these foods you may need to create a list of preventive measure of type 1 diabetes or perhaps type 2 diabetes posted in your fridge., See what your medical symptoms could mean, and learn about possible conditions.

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@ Genetics And Diabetes Ketoacidosis And Diabetes

# Type 2 Diabetes Genetics # Treating Diabetic Blisters Diabetes Effect On Eyes The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days.[ TYPE 2 DIABETES GENETICS ] The REAL cause of Diabetes ( Recommended ),Type 2 Diabetes Genetics In diabetes type 2 diabetes the body in a childs body are resistant towards the effects of insulin and glucose increases in the bloodstream. Eventually this causes glucose to achieve dangerous levels in the body. Type 2 Diabetes Genetics In addition the tea made in cold water can not affect a persons sleep. However not all of the kinds of tea leaves can be utilized to make tea in cold water to drink. If you want to make tea in cold water need to choose the categories of tea leaves which containing low content of phosphorus like green tea and oolong tea benefits. It is convenient and healthy to make tea in cold water by us. Type 2 Diabetes Genetics Fat. Butter margarine lard and oils add fat to treats. Fat is also in many dairy and meat product. Try to avoid fried foods mayonnaise-based dishes (unless very good made with fat-free mayo) egg yolks bacon and high-fat goods. Your doctor or dietitian will let you how many grams of fat might eat just a day. When eating fat-free versions of foods (like mayonnaise and butter) check the label notice how many grams of carbohydrates nutrients and vitamins .. Keep in mind that these products often have added your sugar intake.,Type 2 Diabetes Genetics 5-Interrupt stressful thoughts. Practice your breathing techniques when you are aware of stressful leads to. Speaking of stress triggers to take into consideration that if you have had an excessive amount of coffee it may be time to lower just just a little. Type 2 Diabetes Genetics In two diabetes diabetes cellular matrix in childrens body are resistant into the effects of insulin and glucose gathers up in the bloodstream. Eventually this causes glucose achieve dangerous levels in human body. Type 2 Diabetes Genetics Diabetics end up being properly educated on appropriate ways to guard their body and ensure continued properly. This article provides good tips employed to all people suffering from diabetes as well as family members and friends., See what your medical symptoms could mean, and learn about possible conditions.

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@ Type 2 Diabetes Genetics Can Diabetes Cause Stroke

# Probiotics And Diabetes # Diabetic Treatment For Burns Aic Diabetes The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days.[ PROBIOTICS AND DIABETES ] The REAL cause of Diabetes ( Recommended ),Probiotics And Diabetes There are well over 30+ ways start with to cure the regarding GERD naturally. I will give you 5 GERD remedies to start your treatment at home. Though you will not fill immediate relief like antacids you can be assured that these remedies will permanently cure this disease over spare time. Probiotics And Diabetes Always combine what is on your plate each and every meal or snack. Combine carbohydrates with healthy fats and proteins. Make sure additionally you get raw fruits and vegetables too. Eating fiber rich foods will definitely help regulate how fast your body absorbs blood sugar. Ensure you choose healthy plant-based fats over meat fats whenever suitable. That will definitely help keep cholesterol manageable. Add whole grains to doing it . as extremely well. They absorb much slower than their refined cousins absorb and demands to function properly fiber. Probiotics And Diabetes Many insurance firms now cover acupuncture. Consumer demand can have spiked this interest but maybe directly will secure the potential advantages TCM brings if it keeps money in their bank balance. This trend is essential as Western and Eastern medicine set out to co- happen in primary therapy. Health reform starts individually with what you is capable of doing to build up your own health. TCM helps you start on the actual foot.,Probiotics And Diabetes Let me share with you how diabetes got its name. In the victorian era the Greek who started calling it as diabetes which means siphon. Offer based on its distinguishable characteristics to urinate with greater regularity and copiously when unattended. Then on the seventeenth century statement mellitus was added and that means sweet. Have you know that in the days 1 of the popular methods of diagnosing diabetes is to taste the patients pee. My grandmother even mentioned that they used ants because ants love sugar. Probiotics And Diabetes The cause vegetables nuts and fruit are recommended as diabetes diet people is mainly because they contain soluble fibers which minimize the absorption of glucose of ones intestines. In fact legumes like kidney beans higher soluble fiber and carrots are extremely bet. Probiotics And Diabetes An important part of best diabetes treatment is exercise. Everyone says diet and exercise but they could be recycled separate. This has to hold your exercise session. While exercise can use up BG (blood glucose) thats not its essential use for Type 2 diabetics. Type 2 is avert probably have unless possibly immediately add insulin as well as the onset was sudden. Exercise for Type 2s readjusts your metabolism and also lowers insulin push back. Insulin resistance is really whats wrong with you. That glucose in your blood has trouble all through the cell walls. So dont forget exercise. And exercise makes the necessary diet less hard., See what your medical symptoms could mean, and learn about possible conditions.

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@ Probiotics And Diabetes Genetics And Diabetes

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The Cartoon Guide to Genetics (Updated Edition): Larry ...