GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work.

While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor's journal.

The editors make decisions quickly in around 35 days without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists.

GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook . For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we've published thematic collections, including Genomic Prediction, Multiparental Populations, Genetics of Immunity, and Genetics of Sex.

More than just a publisher, the Genetics Society of America is mission-driven and places a high priority on responding to community needs. GENETICS and G3 have long been committed to supporting resources that serve scientists. We were the first journals to partner with Cold Spring Harbor Laboratories to enable seamless deposits of manuscripts from our submission systems straight into the preprint server bioRxiv, as well as from bioRxiv to GENETICS and G3, and we have accepted submissions posted for preprint servers since 2012. Articles feature links to model organism databases like SGD, FlyBase, and WormBase. We have also partnered with Overleaf to provide custom templates for authors who use LaTex, saving them time at submission. Our collaboration with protocols.io, encourages authors to freely share methods from GENETICS articles, helping to increase research reproducibility. The annotation tool Remarq is available on both the GENETICS and G3 websites and allows for collaborative commenting and article sharing. Our latest collaboration with Figshare ensures that supplemental material and data files are permanently associated with an articleand that authors arent limited by file type or size when providing data that support their work. Early online publication means that research investigations are freely accessible and in PubMed within days of acceptance which eliminates delays in discovering the latest science.

For information on the Genetics Society of America, please visit the GSA Home Page.

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About GENETICS | Genetics

APA format:

Genetic Science Learning Center. (2018, October 23) Gel Electrophoresis.Retrieved February 18, 2019, from https://learn.genetics.utah.edu/content/labs/gel/

CSE format:

Gel Electrophoresis [Internet]. Salt Lake City (UT): Genetic Science Learning Center; 2018[cited 2019 Feb 18] Available from https://learn.genetics.utah.edu/content/labs/gel/

Chicago format:

Genetic Science Learning Center. "Gel Electrophoresis." Learn.Genetics.October 23, 2018. Accessed February 18, 2019. https://learn.genetics.utah.edu/content/labs/gel/.

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Gel Electrophoresis - Genetics

DNA from the Beginning - An animated primer of 75 experiments that made modern genetics.

DNA from the Beginning is organized around key concepts. The science behind each concept is explained by: animation, image gallery, video interviews, problem, biographies, and links.

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DNA from the Beginning - An animated primer of 75 ...

For over 150 years, Darwins hypothesis that all species share a common ancestor has dominated the creation-evolution debate. Surprisingly, when Darwin wrote his seminal work, he had no direct evidence for these genealogical relationships. Now, with online databases full of DNA-sequence information from thousands of species, the direct testing of Darwins hypothesis has finally commenced. More...

Authentic speciation is a process whereby organisms diversify within the boundaries of their gene pools, and this can result in variants with specific ecological adaptability. While it was once thought that this process was strictly facilitated by DNA sequence variability, Darwin's classic example of speciation in finches now includes a surprisingly strong epigenetic component as well. More...

One of the rapidly expanding and exciting research fields in molecular biology is the area of epigenetics. In the study of epigenetic modifications, scientists analyze DNA that has been modified in such a way that its chemistry is changed, but not the actual base pairs that make up the genetic code of the sequence. Its like a separate control code and system imposed upon and within the standard code of DNA sequence.

Because epigenetic modifications in the genome are related to gene expression, researchers have been using highly advanced technologies for comparing these differences in humans and chimps for regions of the genome that they both have in common. More... More...

Living things develop partly according to genetic instructions encoded on their DNA. The study of inheritance has widened the paradigms from genes to genomes, and now recent research indicates that critical biological information is carried from one generation to the next in systems additional to DNA, called epigenetic factors.

So, where did this information come from? More...

Genes could be thought of as brick molds, used to construct materials for building the physical structures of living organisms. They carry the codes to help make proteins, which then make up different cells that are combined together to form mega-structures called tissues.

New research has shed more light on how genes are used by cells to build the different tissues needed by complex living creatures. More...

Indiana University researchers discovered that certain genes used in developing horned beetle larvae are re-used later to make horns in their adult stage. The studys authors called the genes co-opted, indicating their belief that evolution decided to give them a secondary use. The authors suggestion that gene co-opting offers a possible explanation for the development of novel traits comes up short, however. More...

One of the past arguments for evidence of biological evolution in the genome has been the concept of pseudogenes. These DNA sequences were once thought to be the defunct remnants of genes, representing nothing but genomic fossils in the genomes of plants and animals. More...

Amazingly, scientists documented the activity of 2,082 distinct pseudogenes in the human genome whose aberrant levels of activity were directly associated with cancer-specific pathologies. More...

Proteins do most of the required metabolic tasks within each of the trillions of cells in the human body. However, only about four percent of human DNA contains coded instructions that specify proteins.

So what is the purpose of the remaining 96 or so percent? More...

A research team recently characterized a group of genes in humans and other mammals that not only defies evolutionary models but vindicates the Bibles prediction of the uniqueness of created kinds with distinct genetic features. More...

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Genetics | The Institute for Creation Research

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Genetics is the study of genes and heredity. It studies how living organisms, including people, inherit traits from their parents. Genetics is generally considered part of the science of biology. Scientists who study genetics are called geneticists.

What are genes?

Genes are the basic units of heredity. They consist of DNA and are part of a larger structure called the chromosome. Genes carry information that determine what characteristics are inherited from an organism's parents. They determine traits such as the color of your hair, how tall you are, and the color of your eyes.

What are chromosomes?

Chromosomes are tiny structures inside cells made from DNA and protein. The information inside chromosomes acts like a recipe that tells cells how to function. Humans have 23 pairs of chromosomes for a total of 46 chromosomes in each cell. Other plants and animals have different numbers of chromosomes. For example, a garden pea has 14 chromosomes and an elephant has 56.

What is DNA?

The actual instructions inside the chromosome is stored in a long molecule called DNA. DNA stands for deoxyribonucleic acid.

Gregor Mendel is considered the father of the science of genetics. Mendel was a scientist during the 1800s who studied inheritance by experimenting with pea plants in his garden. Through his experiments he was able to show patterns of inheritance and prove that traits were inherited from the parents.

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Biology for Kids: Genetics - ducksters.com

Cells rarely exist alone, which drives the evolution of diverse mechanisms for identifying and responding appropriately to the presence of other nearby cells. Filamentous fungi depend on somatic cell-to-cell communication and fusion for the development and maintenance of a multicellular, interconnected colony that is characteristic of this group of organisms. The filamentous fungus Neurospora crassa is a model for investigating the mechanisms of somatic cell-to-cell communication and fusion. N. crassa cells chemotropically grow toward genetically similar cells, which ultimately make physical contact and undergo cell fusion. Here, we describe the development of a Pprm1-luciferase reporter system that differentiates whether genes function upstream or downstream of a conserved MAP-Kinase (MAPK) signaling complex by using a set of mutants required for communication and cell fusion. The vast majority of these mutants are deficient for self-fusion and for fusion when paired with wild type cells. However, the ham-11 mutant is unique in that fails to undergo self-fusion, but chemotropic interactions and cell fusion are restored in ham-11 + wild-type interactions. In genetically dissimilar cells, chemotropic interactions are regulated by genetic differences at doc-1 and doc-2, which regulate pre-fusion non-self recognition; cells with dissimilar doc-1 and doc-2 alleles show greatly reduced cell fusion frequencies. Here, we show that HAM-11 functions in parallel with the DOC-1 and DOC-2 proteins to regulate activity of the MAPK signaling complex. Together our data support a model of integrated self and non-self recognition processes that modulate somatic cell-to-cell communication in N. crassa.

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Integration of Self and Non-self Recognition ... - genetics.org

Our genetic make-up is responsible for many of the physical characteristics we are born with,including eye, hair and skin color. Genes will also determine how we are able to metabolize certain nutrients and many of the other characteristics we are destined to have as adults, such as height, handedness and early baldness, for example. Although there is still much we dont know about inherited diseases, we do know that genetics are also responsible for many serious genetic disorders, including genetic birth defects,intellectual disability, cleft lip and palate, developmental abnormalities and neurologic disorders.

The University Hospitals Center for Human Genetics specializes in evaluation, diagnosis, treatment and counseling for individuals of all ages with genetic and metabolic disorders.

The center, an integral part of the Department of Genetics and Genome Sciences of the School of Medicine, is a critical link between clinicians of University Hospitals and researchers of Case Western Reserve University. Together, a team of experts that includes medical geneticists, biochemical geneticists, clinical laboratory geneticists, genetic counselors and research human geneticists serve patients with a variety of conditions. Examples include children with developmental abnormalities and metabolic derangements, pregnant women who have an abnormality detected on prenatal testing and adults with early onset cancer. Some genetic diseases are not yet treatable; therefore, we ensure that patients and their family are carefully educated about prognosis, complications that may occur and the best therapy currently available.

This team of geneticists is supported by state-of-the-art technology in the centers laboratories that focus on clinical cytogenetics, molecular and biochemical diagnostics and prenatal screening.

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Genetic Services | Geneticists Treating Hereditary ...

Cancer research not only advances the state-of-the-art in cancer treatment, it also provides a source of hope and help to patients for whom other treatments have failed. As a member of the Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center is involved in the discovery of new forms of prevention, diagnosis and treatment. UH Seidman Cancer Center research efforts are focused on "developmental therapeutics" quickly translating scientific findings into the highest quality patient care. Thus, UH Seidman Cancer Center patients are among the first in the nation to benefit from the newest investigative cancer treatmentsmany of which are not available outside a research setting.

Clinical trials are research studies that are used to find better ways to diagnose and treat individuals with cancer. UH Seidman Cancer Center offers more than 300 clinical trialsin most cancer diagnoses and stages of disease.

The Cancer Genetics Programat University Hospitals brings together experts from the Center for Human Genetics and University Hospitals Seidman Cancer Center to help families with a history of breast, colon or pediatric cancers.

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Clinical Cancer Research | Cancer Clinical Research ...

The Center for Cardiovascular Genetics at University Hospitals Harrington Heart & Vascular Institute specializes in evaluation, treatment, diagnosis and genetic counseling for individuals of all ages and their family members. The goal of the Center for Cardiovascular Genetics is to identify and treat patients with inherited cardiac conditions, those at risk of developing an inherited cardiac condition, and those who are at risk for sudden cardiac death.

Although many cardiac conditions result from diet, smoking, lack of exercise, high cholesterol, or other medical conditions such as diabetes, some cardiac conditions are the result of a genetic abnormality. These genetic abnormalities can result in problems with the hearts muscle function (cardiomyopathy) or problems with the hearts electrical system, which may put patients at risk for sudden cardiac death.

A genetic abnormality can be inherited and passed down through families. Family members with the same genetic abnormality may present with a variable degree of symptoms. Some patients may have no symptoms and others will have significant symptoms.

Inherited cardiac conditions which may put patients at risk for sudden cardiac death or arrest (SCD/A) include:

Comprising physicians specializing in cardiomyopathy, congestive heart failure, cardiac electrophysiology, medical genetics and a certified genetic counselor, the Center for Cardiovascular Genetics is designed to identify patients with inherited conditions or genetically determined cardiac disease. Diagnosis of an inherited condition can be made using a combination of cardiac and genetic testing.

Consultation with a medical geneticist and certified genetic counselor may be recommended to determine if genetic testing will aid in the diagnosis, direct treatment strategy, and identify other at-risk or affected family members.

As an outpatient clinic, patients may meet and be evaluated by an electrophysiologist (a doctor specializing in heart rhythm disorders), a cardiologist specializing in cardiomyopathy, and a registered nurse.

Cardiac evaluation will include a thorough history and physical examination. Sometimes additional testing may be recommended in order to establish the patients diagnosis or risk. This may include one or more of the following:

Once a diagnosis is made, the patient will meet with the medical geneticist and the genetic counselor to discuss whether genetic testing would benefit them or other members of their family. Genetic testing is done by providing a sample of blood that will be sent to a laboratory where the genetic material will be examined. The genetic analysis will look for abnormal changes in genetic information that are responsible for the inherited cardiac disease.

Once the genetic testing is complete, the patient will return to the Center for Cardiovascular Genetics where the genetic results will be discussed with the geneticist and the genetic counselor. They will explain what the findings mean for the patient and his or her family members. They can also help patients discuss this information with other family members.

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Center for Cardiovascular Genetics | University Hospitals ...

The Center for Human Genetics laboratory is housed instate-of-the-art facilities and has offered genetic screening and diagnostic testing for numerous genetic conditions for more than 25 years.

The laboratory combines clinical practice with genetic research, allowing it to offer patients advanced, innovative diagnostic testing. In addition, as an assurance of its quality, the laboratory is certified by the College of American Pathologists (CAP) and approved by the Clinical Laboratory Improvement Amendments (CLIA). Our faculty includes one board-certified clinical cytogeneticist and one board-certified clinical molecular geneticist/clinical geneticist.

Contact UsW.O. Walker Center6th Floor 10524 Euclid AvenueCleveland, OH 44106216-983-1134

CIDEM is a specialized laboratory with focus on disorders of mitochondrial function. These disorders include defects of pyruvate metabolism, the Krebs cycle, fatty acid oxidation, and the electron transport chain. Clinical conditions associated with these disorders include major disabilities affecting the central nervous system, skeletal muscle, heart and other organs. The goal of CIDEM is to provide specialized diagnostic laboratory services on a clinical and/or research basis to facilitate diagnosis and treatment of patients affected with such disorders.

The laboratory is certified by the Clinical Laboratory Improvement Amendments (CLIA). Our faculty is board-certified in clinical biochemical genetics.

Contact UsWearn Bldg., Room 64911100 Euclid AveCleveland, OH 44106216-844-1286

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Genetic Screenings and Diagnostic Testing | Center for ...