Category Archives: Genetics

Is the consumer genetics fad over? – MIT Technology Review

The CEO of 23andMe told CNBC her company will lay off 100 people as sales of its direct-to-consumer gene tests slump.

This has been slow and painful for us, CEO Anne Wojcicki told the website, which estimated the cuts would pare about 15% of the company's staff.

Boom times: Sales of DNA tests that tell people their ancestry and health facts started booming a few years ago, propelled by TV and Internet ads hawking the promise that people could gain unique insights from their genes.

During 2018, the total number of people who had ever bought the tests doubled, swelling the databases of 23andMe, Ancestry, and several smaller companies to over 26 million people altogether.

The bust: Now, all signs are that sales of the $99 consumer tests slowed dramatically in 2019.

Our own calculations suggest the largest companies sold only four to six million of them, meaning the databases would have grown by just 20% during the year. That would have been the slowest growth rate for the DNA test industry ever.

Uncertain causes: It's not clear why consumers stopped buying tests in droves. It could be that the market is tapped out, and there aren't many people left curious to learn what percent French or Nigerian they are, or whether they are at risk for going bald.

Others may have concerns about their DNA data staying private, since police have started accessing smaller ancestry databases to carry out genetic manhunts.

Ancestry, which maintains the largest database with more than 16 million people, did not answer questions about whether it had seen a sales slowdown. Last year, Ancestry introduced new health offerings in what some analysts saw as a bid spark a "re-testing" market, or coaxing consumers to pay for an additional test.

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Is the consumer genetics fad over? - MIT Technology Review

Local News Doctors weigh in on pros and cons of genetic testing kits Brooke Hafs 5 – WGBA-TV

APPLETON, Wis. (NBC26) -- Genetic testing kits have grown in popularity.

Doctors say there's a time where it is appropriate to use them and a time when the information might not be sufficient.

At 59-years-old, Robin Vandermoss was diagnosed with cancer.

"It has tracked through my father and his father," said Vandermoss. "I just kind of want to put the puzzle together."

Now more than 6 months later he's undergoing genetic testing at ThedaCare.

"Hopefully we end up with some results that can be useful for my children and their children going on," said Vandermoss.

He's taking a route that doctors say is best under his circumstances.

As direct-to-consumer genetic testing kits grow in demand, doctors are informing people there are times to use them and times to seek an alternate route.

"If anybody has a strong personal or family history of cancer, heart disease or other conditions running in their family, then they really need a more formal evaluation," said Bobby McGivern, a Genetic Counselor with ThedaCare Regional Cancer Center.

Here's how these tests work.

You send a saliva sample in the mail. Your sample is tested in a lab and you receive your results revealing a plethora of new information about yourself.

Some examples of traits you can learn from a direct-to-consumer kit are:

Doctors say if you choose to use a gene testing kit that you've ordered online it's best to read the fine print.

Make sure you understand the capabilities of the test and look closely at the privacy information so you know what the lab is doing with your DNA.

Overall doctors say direct-to-consumer genetic testing kits have inspired a valuable trend.

"Families are talking more about family history," said McGivern. "They're asking some of the older relatives what is in the family, or maybe they're initiating some conversations with primary care doctors that they wouldn't have otherwise."

Use the kits wisely and seek a genetics referral from your primary care doctor if you have risk factors or a family history.

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Local News Doctors weigh in on pros and cons of genetic testing kits Brooke Hafs 5 - WGBA-TV

Doing well in school is nothing to be proud of – Daily Nation

By BITANGE NDEMOMore by this Author

We recently celebrated those who passed their 2019 Kenya Certificate of Secondary Education (KCSE).

For several days, newspaper headlines displayed names and pictures of those who scored As. Their performance promises them a place in top Universities in and outside the country.

At college graduations, the very few first-class students are celebrated while a majority limp on in frustration.

I recently read the article by Olivia Goldhill, Doing well in school is nothing to be proud of. The article, published in Quartz, argues that new research presents views contrary to our tradition. I thought it important to review this article.

The study had identified 1,271 genetic variants that are associated with how many years people spend in school. Their result follows on from several other academics papers and years of research identifying the genetic variants associated with educational achievements.

The authors reported that:

These studies do not support the idea that intelligence is all down to genetics: Even with full knowledge of all these variants, an analysis of any one individuals genes could not be used to make a meaningful prediction about whether theyre going to get a PhD or drop out of school. But they do show that genetics have an impact; while genetics do not definitively determine how someone will fare in school, they create certain predispositions. In total, all the genetic variants account for 11 percent of variation in educational attainment across the population.

High achievers feel validated when results correspond to their achievements. The study notes that most cultures in the modern times treat educational success as a sign of moral worth. Parents, communities and teachers celebrate kids who do well in school. They shouldnt.

Latest research findings from the work of Robert Plomin, professor of behavioural genetics at Kings College London also established that genetic data from 20,000 DNA variants across several genes collectively account for between two and nine percent of the differences in childrens educational achievement.

In his paper, Predicting Educational Achievement from DNA, Plomin argues that his findings could herald future widespread use of genetic risk score to predict genetic risk and resilience in the social and behavioural sciences.

These research findings from genes should never be ignored since they have been used before to promote the idea that there is such a thing as genetically-determined intelligence often used as a basis for superiority.

Indeed, as a student in the US, I registered for an advanced math course. In my first class, the professor advised me to change my registration to a similar course offered under Martin Luther (ML) program at the University.

Students widely felt that ML was basically a euphemism for inferior students from different minority groups. I refused to change my registration. After the first continuous test, in which I did well, the professor developed a weird invigilation tactic whenever we had an exam.

He would simply stand behind my back, perhaps trying to ensure that I was indeed the one taking the exam. Although it was a form of intimidation, I ignored it.

Only later did I realise that some of my classmates and the professor considered themselves a superior race.

Goldhills article suggests that, how you perform in the classroom is the result of many things ranging from environmental to biological factors, including but not limited to genetics. The familys socioeconomic status, the level of emphasis that the family places on education and accessibility to good teachers determine the performance of learners. There is also the element of luck where the students skill set conveniently matches exam requirements. Doing well, in school is, largely, a sign of good luck.

Parents in some cases are the greatest problem as it relates to educational performance. In some cases where perhaps one of the children performs poorly, their comments may reinforce failure, especially when they openly address them as weak in academics. The child could be suffering from dyslexia or autism but such comments destroy their confidence.

Instead, the parents should be looking at such children as a category that thinks differently while investigating.

The advent of artificial intelligence has brought adaptive learning, an educational system that adjusts the presentation of learning material in response to student performance.

On the other hand, students who consistently perform well are not without a problem. A single failure could lead to depression. Perhaps the increasing incidences in mental health may be attributable to young people who hitherto have performed well but have recently encountered failure to a point where they feel they are no longer worth anything.

Some research shows that high achievers in some cases feel entitled and less willing to ask for help even when they need it, while others think they are imposters referred to as imposter syndrome.

In the KCSE results where, only 125,746 out of 660,240, or 20 percent of candidates, qualified to go to university, there are thousands who missed university entry requirements but are perhaps as good as those who qualified.

They may never know that it wasnt entirely their fault. Our system of education is unforgiving and often ignores these many reasons for failing to perform well in the exam.

While genetics could be used to explain good performance in education, there is evidence that good performance is, to a large extent, a function of good luck.

Yes, there is a need to acknowledge those who perform well but it must be in moderation. It is equally important to encourage those who have not excelled.

In as much as there are consequences for those who fail, there are also similar consequences for those who pass.

The writer is a professor of entrepreneurship at University of Nairobis School of Business.

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Doing well in school is nothing to be proud of - Daily Nation

A guide to picking the right life science program for you – Varsity

Students in fields from fundamental genetics to bioinformatics and computational biology discussed their fields of study with attendees. COURTESY OF GLOBAL SOCIETY FOR GENETICS AND GENOME BIOLOGY

As second semester rolls in and spring approaches, many first-year life sciences students are starting to consider which program of study they will pursue next year. This is often a time of stress and confusion for students who may not know exactly what they want to study, or even how to start their search.

Fortunately, some University of Toronto student groups are offering their time and wisdom to help first years navigate the multiple programs offered in the life sciences.

The Global Society for Genetics and Genome Biology (GSGGB) hosted a How to choose a life science [program of study] event at New College on January 13. Members of the GSGGB offered their guidance and support to keen first-year students representing the programs of molecular genetics and microbiology, fundamental genetics, bioinformatics and computational biology, ecology and evolutionary biology (EEB), and more.

Students had the opportunity to discuss programs, enrollment requirements, and even research opportunities with the upper-year students, who were eager to share their experiences in their respective programs.

Whats the difference between type 1, 2, and 3 programs?

The Faculty of Arts & Science offers 21 specialist programs, 20 majors, and six minors in the life sciences. Most specialist programs, alongside some majors, such as molecular genetics and microbiology, are known for their competitiveness. These are type 3 programs, which have limited spots available, require minimum grades in certain prerequisite first-year courses, and supplemental information such as a personal statement or audition.

Type 2 programs also require minimum grades in prerequisite courses, but typically have more available spots and lower grade requirements. The neuroscience major is an example one popular type 2 program.

However, many students dont realize that a lot of life science majors and minors are type 1 programs, which do not require any specific courses or grades for enrollment. Common type 1 majors include as global health, EEB, and fundamental genetics, in addition to some lesser-known majors such as animal physiology, or environment and health. As long as a student is on course to obtaining four full-course equivalents by the end of this school year, they will be admitted to any type 1 program.

Where can students learn more about programs of study?

To learn more about programs of study, first-year students are encouraged to visit the program toolkit section of Sidney Smith Commons website. There, they will find a comprehensive list of all programs offered by the Faculty of Arts & Science, how to apply to each, and important dates. This year, enrollment begins on March 1.

Students should also consider meeting with their colleges academic advisors, who can provide guidance regarding program enrollment and degree planning.

Student groups like the GSGGB are also a useful resource for first-year students, who may at times be daunted by the prospect of approaching professors or older students for advice.

Events like How to choose a life science [program of study] provide students with the opportunity to chat in a casual, stress-free environment, while receiving advice from people who were once in their same position.

GSGGB Affairs Leader Aisha Faruqui wrote to The Varsity that there are plenty of life sci clubs like GSGGB that would love to help out puzzled first-year students, and that students should feel free to reach out.

Weve all had moments in undergrad where we have felt lost or uncertain about our future, she noted, so students should never feel alone in their experiences.

U of T offers its students plenty of resources when it comes to academic planning and discovery. Students will have many opportunities to explore interesting fields in the life sciences and to shape their career paths.

Faruqui reflected, Dont stress out about choosing your program, and dont worry about not getting into your desired program after first year!

You can make it work out in the end.

Tags: Careers, education, life sciences, program of study, Science

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A guide to picking the right life science program for you - Varsity

Genetics and lifestyle can be obesity risks – Coshocton Tribune

Emily Marrison, Columnist Published 11:00 a.m. ET Jan. 25, 2020

For better and for worse, we all inherit particular characteristics from our parents.

Maybe its our mothers eyesor maybe our fathers temper. Some of that is directly the result of the DNA weve receivedand some of it comes from the influence they exerted in our environment.

Emily Marrison(Photo: Submitted)

When it comes to our health and wellness, it can be challenging to determine whether nature or nurture has more of an impact. In some cases, it may not really matter. But when it causes you to feel powerless or apathetic about how much you can change your condition, it definitely matters.

Results of a long-term study were recently published in the Journal of the American Medical Association of Cardiology. The study tracked data on more than 2,500 Americans who were followed for decades from young adulthood in 1985 to 2010. One of their findings is that body mass index (BMI) in youth appears to be the best predictor of long-term obesity risk.

There have been other studies in recent years that have identified certain genes that are believed to be responsible for a person becoming overweight and obese. There are rare inherited causes of obesity, but this is not the case for the majority of the population. This study suggests that daily lifestyle is the more important factor for determining our weight.

When we look at the BMI of children, this is showing the result of genetics as well as environment. The genes we inherit can certainly make us more susceptible to weight gain, but that doesnt mean it is inevitable. Hopefully, this research can empower people to know that being obese doesnt have to be someones destiny. Their healthy lifestyle choices the foods they eat, their portion sizesand physical activity can result in a better quality of life.

According to the National Heart, Lungand Blood Institute, being overweight or obese increases your risk of developing heart disease, high blood pressure, type 2 diabetes, gallstones, breathing problems and certain cancers. A European study linked obesity to a nearly six-fold increased risk of developing type 2 diabetes.

If you are looking for ways to learn more about healthy lifestyle choices while managing diabetes, theOSU Extension has some great resources available. I am pleased that we will be partnering with the Coshocton Regional Medical Center this April to offer Dining with Diabetes. This is a cooking school and nutrition education program designed for people with diabetes and their family members or caregivers.

Dining with Diabetes will be held from 5:30 to 7:30 p.m. Mondays April 6 to 27 at Coshocton Regional Medical Center, 1460 Orange Street, Coshocton. The cost of the program is $20 per person and includes all four classes, educational handoutsand small-sized meals that feature a variety of recipes. You are encouraged to also register a support person to attend with you for an additional $5. You can find more details and registration information at coshocton.osu.edu.

Today, Ill leave you with this quote from Billy Graham, When wealth is lost, nothing is lost; when health is lost, something is lost; when character is lost, all is lost.

Emily Marrison is an OSU Extension Family & Consumer Sciences Educator and may be reached at 740-622-2265.

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Genetics and lifestyle can be obesity risks - Coshocton Tribune

23andMe just laid off 100 employees as the DNA-testing ‘fad’ ends – Business Insider – Business Insider

DNA-testing giant 23andMe is laying off about 14% of its staff, the latest sign of a slump in the business.

About 100 employees have been let go in departments across the organization in an effort to scale back on work that isn't core to the consumer testing and therapeutics businesses that 23andMe operates, a spokesman told Business Insider. The therapeutics team was not impacted by the layoffs, he said.

CNBC's Christina Farr reported on the layoffs earlier on Thursday.

23andMe will also be scaling back on its work recruiting for clinical trials, the spokesman said.

Over the past few years, genetic tests have grown in popularity. That's helped consumer genetics companies like 23andMe grow to 10 million users who've shipped off their spit with the hopes of learning more about their family trees, genetic traits, or even some health information.

Along the way, there have been beenflags raised about ethics and privacy, along with a slew of tough questions about identity and family.

Still, for years, it seemed like interest in genetic testing was only increasing. But in 2019, the companies started to run into a slowdown.

Read more: The DNA-testing 'fad' is over, and one company just halted operations. The CEOs of Ancestry and 23andMe reveal how they're fighting back.

The first warning was raised by Illumina, the company that makes all the tech that's used to read info about your genes. On an earnings call in July, the company noted "softness" in the market.

And in December, Veritas Genetics, a company that provides whole-genome sequencing for $600, said it had suspended its US operations, citing issues raising additional funding.

"It's a new technology, and I think it's hit a lull," 23andMe CEO Anne Wojcicki told Business Insider in an October interview on the sidelines of a conference.

She attributed that in large part to privacy concerns coming in from the tech industry, or what she calls the "Facebook Effect."

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23andMe just laid off 100 employees as the DNA-testing 'fad' ends - Business Insider - Business Insider

Genetic test developed to predict onset of glaucoma – The Siasat Daily

Washington: A group of researchers from Australia has formulated a genetic test that could detect peoples susceptibility towards developing glaucoma, which is a debilitating ocular disease that can potentially make its sufferers go blind.

The team of scientists suggests that there are 107 genes that are responsible for the onset of this condition.

They are looking forward to 20,000 peoples participation in their Genetics of Glaucoma Study in order to help them find more genes involved in the disease.

Glaucoma is characterised by progressive damage and degeneration of the optic nerve which also causes gradual loss of vision. It is the leading cause of irreversible blindness worldwide and is predicted to affect 76 million people by 2020.

There is still no proven cure for the disease, but treatment can reliably slow or halt deterioration in most cases. Up to 50 percent of those affected are not even aware.

Stuart MacGregor, lead researcher and the head of QIMR Berghofers Statistical Genetics Group, Associate Professor, said that identifying new genes allowed them to develop a glaucoma polygenic risk score (PRS) that can predict who is likely to get the eye disease.

Glaucoma is a genetic disease and the best way to prevent the loss of sight from glaucoma is through early detection and treatment, MacGregor defined.

Our study found that by analysing DNA collected from saliva or blood, we could determine how likely a person was to develop the disease and who should be offered early treatment and/or monitoring, he added.

He also feels that unlike existing eye health checks that are based on eye pressure or optic nerve damage, the genetic test can be done before damage begins so that regular screening can be put in place.

Clinical lead researcher and academic head of the Department of Ophthalmology at Flinders University, Professor Jamie Craig, said that the study results gave hope that mass screening for glaucoma could be offered in the future.

There are Australians who, if theyd had appropriate treatment a few years earlier, wouldnt have gone blind, said Professor Craig, who is also a consultant ophthalmologist.

One in 30 Australians has glaucoma, but most people only find out they have it when they go to the optometrist because they are losing vision, or for a general eye check, shares Craig, continuing, Early detection is paramount because existing treatments cant restore vision that has been lost, and late detection of glaucoma is a major risk factor for blindness.

He said that glaucoma can arise at any age but most of those affected are in their 50s or older, so their aim is to offer blood tests to people of that age to find out if they are at risk, and then hopefully act on it.

This test is likely to be helpful in identifying those who would benefit from a more aggressive intervention such as surgery rather than simple eyedrops.

The researchers are hoping to get in touch with people with a family history of the disease. We want to know who will get glaucoma, and for those who are susceptible, we want to be able to pinpoint at what age theyre going to get it, said Associate Professor MacGregor.

The researcher concluded, That would allow us to develop a personalised approach for earlier treatment of high-risk individuals, and means people at lower risk could have less intensive monitoring and treatment. This would have benefits for patients, doctors and the health care system with reduced interventions and reduced costs.

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Genetic test developed to predict onset of glaucoma - The Siasat Daily

GyanSys Selected by AgReliant Genetics as the Primary Partner for Their Implementation of SAP S/4HANA as Part of Their Digital Transformation -…

CARMEL, Ind., Jan. 24, 2020 /PRNewswire/ --AgReliant Genetics, a leader in seed research, production and provider of seed solutions, signed a contract with GyanSys Inc. ("GyanSys"), a leading IT services provider headquartered in Indiana, to implementSAP S/4HANA on HANA Enterprise Cloud (HEC) as part of their digital transformation journey to replace their legacy ERP systems.

Steve Thompson, CIO of AgReliant Genetics "GyanSys led our team to conduct S/4HANA Best Practice workshops, gap analysis, and recommended the right SAP software bill-of-materials. AgReliant is excited to start our digital transformation journey partnering with GyanSys to build a scalable digital core for our Finance, Purchasing, Planning, Sales, Manufacturing, and Warehouse Management systems."

Rajkishore Una, President & CEO of GyanSys "GyanSys is committed to successfully deliver AgReliant Genetics' new SAP environment with our global delivery approach and our best practice-led implementation methodology. We are bringing our expertise in SAP S/4HANA digital core, alongside BPC, EWM, aATP, Manufacturing for Planning & Scheduling, and Analytics Cloud, for AgReliant to derive the most value from this strategic investment."

About AgReliant Genetics:

AgReliant Genetics offers corn, soybean, sorghum, and alfalfa seed solutions to farmers through their product brands. Contact your local AgriGold, LG Seeds, or PRIDE Seeds representative for more information.

Learn more about AgReliant Geneticsat http://www.agreliantgenetics.com.

About GyanSys Inc.:

GyanSys is a mid-tier global systems integrator specializing in SAP, Salesforce, Microsoft, and ServiceNow Platforms to improve the Sales, Finance, Supply Chain, Manufacturing, Operations, and HR business processes to support digital transformation.

Headquartered in Indiana, GyanSys was founded in 2005 and has approximately 1,000+ professionals globally serving 125+ customers across various industries, including the manufacturing, automotive, high-tech, CPG, and life sciences industries.

For more information about GyanSys, visit http://www.gyansys.com.

For press inquiries and more information, contact:Cliff SaitoDigital Marketing ManagerE-mail: cliff.saito@gyansys.com

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What Causes Autism? Researchers ID 102 Genes Linked to Condition – Healthline

In the largest genetics study of its kind to date, scientists have identified 102 genes associated with the risk for autism spectrum disorder (ASD).

Researchers also gained further insight into which of these genes are associated with both ASD and other disorders that cause intellectual disability and developmental delay.

For the study, an international team of researchers analyzed more than 35,000 participant samples, including almost 12,000 from people with ASD.

Researchers used a genetic technique called exome sequencing, which looks at all the regions of a persons genetic information or genome that are translated into proteins. This testing can pick up rare genetic mutations that might not show up with other methods.

Dr. Lonnie Zwaigenbaum, a professor in the Department of Pediatrics and the Stollery Childrens Hospital Foundation Chair in Autism at the University of Alberta, called this an exciting study, both for the sophisticated methods used and the large sample size.

These enabled researchers to identify a larger number of genes than ever before, which gives insight into how those genes operate and how they might increase the risk of ASD, said Zwaigenbaum, who wasnt involved in the research.

The study results were published January 23 in the journal Cell.

ASD is a group of neurological and developmental conditions that affect communication and behavior. Theres wide variation in the type and severity of symptoms in people with ASD.

Scientists believe that both genes and environment are involved in the development of ASD, with genetics playing a big part.

We know that inherited and unique mutations in the genome are a major source of risk for developing ASD, but specific causes of ASD are not yet well understood, said Lori J. Warner, PhD, director of the Center for Human Development and Ted Lindsay Foundation HOPE Center at Beaumont Childrens Hospital in Royal Oak, Michigan, who wasnt involved in the study.

Although environmental factors play some role in ASD, scientific studies have found that theres no link between receiving vaccines and developing ASD.

The new study marks an important step forward in scientists understanding of the genetic basis of ASD.

Researchers identified both inherited genetic mutations and de novo mutations ones that occur spontaneously when an egg or sperm form.

They also found that the ASD genes identified in the study can affect brain development or brain function. And they showed that two major types of nerve cells can be affected in ASD.

Of the 102 genes identified in the study, 49 were associated with other developmental delays.

Some genes appear connected to the development of ASD, whereas others may increase risk for ASD plus severe neurodevelopmental disorder, said Warner. We dont yet understand fully this process, but differentiating ASD from other disorders is important for effective treatment.

Zwaigenbaum said the overlap between ASD and other neurodevelopmental disorders fits with previous research.

This study reinforces that there are many genes that may have some role in autism vulnerability, but that also have a broader role in early brain development, said Zwaigenbaum.

These genes have a broader expression in terms of developmental abilities and challenges of the affected individual.

While scientists now understand ASD better as a result of this study, this kind of research also points toward better ways to help children with ASD.

The greatest benefit of studies of this type is helping researchers, families, and interventionists better understand how genetic factors actually function in the developing brain and body of the individual, said Warner, so that treatments can be developed to ameliorate or completely block the disruptive changes that lead to disorders such as ASD.

But Zwaigenbaum cautions that the results of the study will not lead to clinical benefits right away.

Theres a lot of translational work that would still need to happen in order to assess whether the findings from this study will directly inform assessment, diagnosis, or treatment, he said.

Still, he said the results provide direction for future research into potential biological treatments, as well as genetic tests that could allow earlier diagnosis of ASD.

Warner said there are medications currently approved for use in children with ASD, but they address symptoms like agitation or anxiety, rather than the core social or behavioral deficits of ASD.

Early diagnosis is another goal of ASD research, because the sooner children are identified and appropriately assessed, the sooner families can receive needed supports, said Warner.

But ASD is a complex condition, so genetic diagnosis isnt always straightforward.

Although studies like this continue to expand our appreciation for the increasing number of genes associated with ASD, the reality is that a genetic cause is seldom identified in most children with ASD even with the most sophisticated genetic testing, said Andrew Adesman, MD, chief of Developmental & Behavioral Pediatrics at Cohen Childrens Medical Center in Queens, New York, who wasnt involved in the study.

But he said theres still value in parents of a child with ASD seeking out genetic testing, especially as genetic technologies advance.

There have been steady gains in terms of the diagnostic yield of genetic testing, said Adesman. For this reason, parents of children with ASD may wish to discuss with their pediatrician whether their child should have the newer genetic tests done.

In the absence of a simple test for ASD, there are still things parents can do for their children.

The single most important things families and healthcare providers can do is to be aware of the risk factors and early signs and symptoms of autism, and get connected with needed services as soon as possible, said Warner.

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What Causes Autism? Researchers ID 102 Genes Linked to Condition - Healthline

Quest buys Helsinki-based Blueprint Genetics to expand reach – MedTech Dive

Dive Brief:

Though FDA is ramping up its scrutiny of genetic tests claiming to predict individual patient responses to drugs,payers have become more open to the idea of reimbursing for the tests. In response, major labs and pharmaceutical companies are scrambling to establish relationships with DNA sequencing players that could be lucrative down the line.

Blueprint, founded in 2012,provides genetic diagnostics of rare diseases based on an NGS method developed at Stanford, which was an early investor in the startup. The eight-year-old company has scaled relatively quickly by decreasing the price of genetic diagnostics while adding clinical insights through gene variant interpretation of the results, identifying associations between quirks in the gene and potential diseases and treatment responses.

Quest already sells more than 700 genetic tests but is looking to Blueprint to spur growth across diseases and geographies.

"Blueprint Genetics has developed a proven model for delivering highly specialized genetic insights that we believe we can scale to serve new patient populations with unmet clinical needs," Quest CEO Steve Rusckowski said in a Wednesday statement.

It's the latest acquisition from Quest as the 53-year-old lab behemoth elbows for market share with Burlington, North Carolina rival LabCorp. Quest has embarked on sustained M&A over the past three years, most recently nabbing the clinical lab services of Columbia, Missouri-based Boyce and Bynum Pathology Laboratories in November 2018.

Though the pace of acquisitions last year was slower than Wall Street expected, both Quest and LabCorp reiterated their eat-or-be-eaten strategy at the J.P. Morgan Healthcare Conference in San Francisco earlier this year, highlighting acquisitions and market share gains as key drivers of diagnostic growth.

Blueprint, which operates in more than 70 countries, "considered joining forces with several organizations" before agreeing to be acquired by Quest, according to Tommi Lehtonen, Bueprint's CEO, who will stay on as VP and general manager. The privately held DNA player has raised more than $26 million over four funding rounds, most recently a Series B round in November, and brings in an estimated $4 million in annual revenue, according to Owler.

As the biopharma business grows, Blueprint opened its first North American lab in October: a hub facility in Seattle. The company says it plans to scale further by leveraging Quest's national infrastructure (it serves half the health systems and providers in the U.S.), though Quest noted Blueprint will continue to "operate largely independently" from its headquarters in Helsinki.

Unlike the roiling direct-to-consumer space, Blueprint's genetic tests are targeted for hospitals and research groups. But there's significant overlap between players, especially as heavy hitters Ancestry and 23andMe look to carve out market share in health testing. Ancestry announced in October it was partnering with clinical labs, including Quest and rival Illumina, to sell physician-ordered tests for genes relates to heart disease and other conditions.

Quest plans to announce fourth quarter earnings Jan. 30.

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Quest buys Helsinki-based Blueprint Genetics to expand reach - MedTech Dive