Category Archives: Biochemistry

Malang’s new songs & # 039; Hamarah & # 039; But get ready to dancing, may be circulated about this time – Sahiwal Tv

January 22, 2020 medical

new Delhi. After wooing fans with all the groovy lyrics of Mohit Suri's film 'Malang', the producer is currently prepared to win the minds associated with the market with all the most recent track 'Humraah'.

'Humraah' tune of 'Malang' may be circulated the next day 'Hamarah' into the sound of Sachet Tandon is created by Kunal Verma which is circulated the next day and remember the motif associated with the movie, it is an exciting and colorful vibe tune.

->In 'Humrah', people are certain to get a deeper glance at the sizzling biochemistry between Aditya Roy Kapoor and Disha Patani.

Aditya and Disha may be seen performing adventure recreations Aditya and Disha may be seen playing plenty of adventure recreations like sky scuba diving, sub wing, liquid kitesurfing, driving quad bicycles etc. in this tune. While the present launch subject tabs on 'Malang' is showing become a chartbuster hit, the movie's debut tune 'Chala Ghar Chalen' is a soulful tune which has created an unique invest the minds associated with the market.

The film 'Malang' is likely to be circulated about this time 'Malang' is perhaps all set to discharge on 7 February 2020, which was shot in Mauritius, Goa and elements of Mumbai. The exact same, the secret and biochemistry noticed in the truck has actually certainly made it probably the most awaited truck associated with the period.

Malang is directed by Mohit Suri and created by Bhushan Kumar, Krishna Kumar of T-Series, Luv Ranjan, Ankur Garg of Love Films and J Shevakramani of Northern Lights Entertainment.

Biochemistry

Study reveals new mechanism involved in the pathogenesis of IBD – News-Medical.net

January 22, 2020 medical

Inflammatory bowel disease (IBD) is a category of refractory inflammatory disease, of which ulcerative colitis (UC) and Crohn's disease (CD) are the main types.

Current studies suggest that IBD is a complex autoinflammatory disease determined by genetic and environmental factors, and is the major cause of gastrointestinal cancer. Because of its complex and refractory character, researchers have focused on determining the detailed pathogenesis of IBD and finding an effective therapy for it.

In a study published online in PNAS on Jan. 20, Prof. SUN Bing's team from the Center for Excellence in Molecular and Cellular Science, Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, in collaboration with Prof. LIU Jie from Huashan Hospital, Fudan University, revealed a new mechanism involved in the pathogenesis of IBD and suggested therapeutic targets for clinical trial.

Among the identified IBD-susceptibility genes (NOD2, IL-23, etc.), extracellular matrix protein-1 (ECM1) gene was found to be strongly related to UC in 2008. Since 2011, several studies from SUN's lab have reported the disease-related functions of ECM1 in Th2, Th17 and Tfh cells. However, no available evidence suggested that ECM1 plays a direct role in IBD.

In this study, the researchers analyzed tissue samples from patients with ulcerative colitis and a DSS-induced IBD mice model.

They found that ECM1 was highly expressed in macrophages, particularly tissue-infiltrated macrophages under inflammatory conditions, and ECM1 expression was significantly induced during IBD progression. The macrophage-specific knockout of ECM1 resulted in increased arginase 1 (ARG1) expression and impaired polarization into the M1 macrophage phenotype after lipopolysaccharide (LPS) treatment.

Further study showed that ECM1 protein could regulate M1 macrophage polarization through the GM-CSF/STAT5 signaling pathway. Pathological changes in mice with dextran sodium sulfate-induced IBD were alleviated by the specific knockout of the ECM1 gene in macrophages.

These results reveal a role for the IBD-susceptibility gene ECM1 in colitis and the possible existence of a GM-CSF/STAT5 regulatory axis in macrophages, indicating that the attenuation of ECM1 function in macrophages is a potential strategy for IBD therapy.

Biochemistry

Astrobiologist explains why there may be invisible aliens among us. – Tech Ballad

January 22, 2020 medical

Life is pretty easy to learn. He moves, he grows, he eats, he secrete, he multiplies. Simply. In biology, researchers often use the abbreviation MRSGREN to describe it. It refers to movement, breathing, sensitivity, growth, reproduction, excretion and nutrition.

But Helen Sharman, the first British astronaut and chemist at Imperial College London, recently said that alien life forms that cannot be found can live among us. How could this be possible?

Although life can be easily recognized, it is actually difficult to define, and scientists and philosophers have argued for centuries, if not millennia. For example, a 3D printer can reproduce itself, but we would not call it alive. On the other hand, the mule is famously sterile, but we would never say that he does not live.

As no one can agree, there are over 100 definitions of what life is. An alternative (but imperfect) approach describes life as a self-sustaining chemical system capable of Darwin evolution, which works in many of the cases that we want to describe.

(Read: aliens exist, but we are not open enough to see them)

Lack of definition is a huge problem when it comes to finding life in space. Failure to define life other than we will know it when we see it means that we really confine ourselves to geocentric, perhaps even anthropocentric ideas about how life looks. When we think of aliens, we often portray humanoid creatures. But the intelligent life we seek does not have to be humanoid.

Sharman says that she believes that aliens exist, and there are no two ways. She also wonders: Will they look like you and me, made up of carbon and nitrogen? Probably no. Perhaps they are here now, and we simply cannot see them.

Such a life will exist in the shadow biosphere. By this I do not mean the realm of ghosts, but undetected creatures, possibly with a different biochemistry. This means that we cannot study or even notice them, because they are beyond our comprehension. Assuming that it exists, such a shadow biosphere is likely to be microscopic.

So why didnt we find it? We have limited opportunities to study the microscopic world, since only a small percentage of microbes can be cultured in the laboratory. This may mean that there really can be many life forms that we have not yet noticed. Now we have the opportunity to sequence the DNA of uncultured strains of microbes, but this can only be detected by the life that we know which contains DNA.

However, if we find such a biosphere, it is not clear whether we should call it a stranger. It depends on whether we mean extraterrestrial origin or simply unfamiliar.

A popular alternative biochemistry proposal is based on silicon, not carbon. This makes sense even from a geocentric point of view. About 90 percent of the Earth is made up of silicon, iron, magnesium and oxygen, which means there are many opportunities for creating potential life.

Artists impression of silicone life form. Zita

Silicon is like carbon, it has 4 electrons to create bonds with other atoms. But silicon is heavier, with 14 protons (protons make up the atomic nucleus with neutrons) compared with six in the carbon nucleus. Although carbon can create strong double and triple bonds to form long chains, useful for many functions, such as building cell walls, silicon is much more complex. He is struggling to create strong bonds, so molecules with long chains are much less stable.

Moreover, conventional silicon compounds, such as silicon dioxide (or silicon dioxide), are usually solid at terrestrial temperatures and insoluble in water. Compare this, for example, with highly soluble carbon dioxide, and we will see that carbon is more flexible and provides much more molecular possibilities.

Life on Earth is fundamentally different from the basic composition of the Earth. Another argument against the silicon-based shadow biosphere is that there is too much silicon in the rocks. In fact, the chemical composition of life on Earth has an approximate correlation with the chemical composition of the Sun, with 98 percent of the atoms in biology being made up of hydrogen, oxygen, and carbon. So, if there were viable life forms of silicon, they could have developed elsewhere.

However, there are arguments in favor of silicon-based life on Earth. Nature is adaptable. A few years ago, scientists at the California Institute of Technology managed to bring out a bacterial protein that created bonds with silicon essentially driving silicon. Thus, although silicon is inflexible compared to carbon, it may be able to find ways to assemble into living organisms, potentially including carbon.

And when it comes to other places in space, such as the moon of Saturns Titan or planets orbiting other stars, we certainly cannot rule out the possibility of life based on silicon.

To find it, we must somehow think outside the framework of terrestrial biology and find ways to recognize life forms that are fundamentally different from carbon-based forms. There are many experiments to test these alternative biochemical methods, for example, from Caltech

Regardless of the belief of many that life exists elsewhere in the universe, we have no evidence of this. Therefore, it is important to consider all life as precious, regardless of its size, quantity or location. Earth supports the only known life in the universe. Therefore, no matter what form life can take elsewhere in the solar system or the universe, we must be sure that we will protect it from harmful pollution whether it be earthly life or alien life forms.

So can aliens be among us? I do not believe that we were visited by a living form with the technology to travel through vast outer spaces. But we have evidence that carbon-based life-forming molecules arrived on Earth on meteorites, so the data certainly does not preclude the same possibility for more unfamiliar life forms.

This article is reprinted from Conversation by Samantha Rolfe, lecturer in astrobiology and chief technical specialist at the Bayfordbury Observatory, University of Hertfordshire, licensed under Creative Commons. Read the original article.

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Astrobiologist explains why there may be invisible aliens among us. - Tech Ballad

Biochemistry

The Business Strategies Accepted By Leading Players In The Biochemistry Analyzers Market | (List: Abbott Laboratories,Danaher Corporation and more) -…

January 22, 2020 medical

The newest research report andinnovative strategies on Biochemistry Analyzers Marketexamined by Marketresearch.biz encloses a comprehensive analysis of the market and was conducted across a variety of industries in various regions to produce more than 100+ page reports. Biochemistry Analyzers concludes with precise and authentic market estimations considering all the parameters and market dynamics. Segmentation of the market is studied specifically to give profound knowledge for supplementary market investments.

Biochemistry Analyzers study is a perfect blend of qualitative and quantifiable information highlighting key market developments, industry, absolute opportunity assessment and competitors challenges in gap analysis and may be trending in the Biochemistry Analyzers market. The strategies followed by leading Biochemistry Analyzers market players which can reflect growth during the forecast period 2020-2029 is analyzed during this report. The past market development, opportunities, and market risks are covered during this study. the elemental Biochemistry Analyzers Market overview, development scope, market dynamics, growth challenges, and influencing factors are briefed.

The Renowned Players-Abbott Laboratories, Danaher Corporation, Hoffman-La Roche Ltd, Meril, Siemens AG, Hologic Inc, Thermo Fisher Scientific Inc, Randox Laboratories Ltd, Beckman Coulter Inc, Horiba Medical

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Biochemistry Analyzers Market Segmentation Overview:

Global biochemistry analyzers market segmentation, by type:

Semi-AutomaticFully AutomaticGlobal biochemistry analyzers market segmentation, by modality:

Bench TopFloor StandingGlobal biochemistry analyzers market segmentation, by end user:

HospitalsDiagnostics CentersAcademic Research InstitutesContract Research OrganizationsPharmaceutical and Biotechnology Companies

The research provides answers to the following key questions:

1) Who are the key Top Competitors in the Global Biochemistry Analyzers Market?

Following are the list of key players: Abbott Laboratories, Danaher Corporation, Hoffman-La Roche Ltd, Meril, Siemens AG, Hologic Inc, Thermo Fisher Scientific Inc, Randox Laboratories Ltd, Beckman Coulter Inc, Horiba Medical

2) What is the expected market size and growth rate of the Biochemistry Analyzers market for the period 2020-2029?

** The Values marked with XX is confidential data. To know more about CAGR figures fill in your information so that our business development executive can get in touch with you.

3) Which Are The Main Key Regions Cover in Reports?

Geographically, this report is segmented into several key Regions, consumption, revenue (million USD), and market share and growth rate of Biochemistry Analyzers in these regions, from 2020 to 2029 (forecast), covering North America, Europe, Asia-Pacific, etc

4) Can I include additional segmentation/market segmentation?

Yes. Additional granularity/market segmentation may be included depending on data availability and the difficulty of the survey. However, you should investigate and share detailed requirements before final confirmation to the customer.

Global Biochemistry Analyzers Market Research Report comprises holistic business information and changing trends in the current market that enables users to spot the pin-point analysis of the market along with growth, revenue and profit during the forecast period 2020-2029. It provides an in-depth study of Biochemistry Analyzers Market by using SWOT analysis. This gives a complete analysis of drivers, restraints, and opportunities of the market. Additionally, the report provides a detailed study of top players within the market by highlighting their product description, business overview, and business strategy. It also endows with a quantity of production, required raw material, future demand, and the money health of the organization.

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Biochemistry Analyzers market research report also involves the manufacturing process along with shipment, price, interview records, gross profit, potential, revenue, business distribution, etc. This enables users to get a complete scenario of competitive analysis of the market.

Also, Biochemistry Analyzers survey report offers Porters Five Forces analysis and PESTLE analysis for more detailed contrast studies. Each section of the report has something valuable that helps companies for improving their sales and marketing strategy, gross margin, and profit margins. Using the report as a tool for gaining insightful Biochemistry Analyzers market analysis, players can identify the much-required changes in their operation and improve their approach to doing business.

In this study, the years considered to estimate the market size of the Biochemistry Analyzers are as follows:

Base Year: 2019 | Estimated Year:2020 | Forecast Year: 2020 to 2029

Table of Content:

Market Outline:The report lists the merchandise overview, applications, product highlights including price, revenue, sales, rate of growth, and market share study.

Competition by Top Players:Worldwide market players and their Biochemistry Analyzers competition by the newest trends, market share, expansion, sales, and acquisitions are stated.

Business Profiles and Sales Analysis:This section stated the sales analysis of top Biochemistry Analyzers Market, manufacturing base, top regions, specifications, and merchandise details are stated.

Market Position and Regional Level View:during this part, the report states the CAGR value, market size estimation by regions and top countries present in North America, Europe, Asia-Pacific, Middle East, and Africa and South America.

Application or user Segment Analysis:This part explains the wide selection of applications that contribute to Biochemistry Analyzers marketing research

Forecast Trend Analysis:Here, the report states forecast Biochemistry Analyzers Industry view and revenue estimates for various segments like product, types, and applications for the forecast period from 2020-2029.

Research Outcomes and Inference:This part of the report mentions the analyst opinions and findings of Biochemistry Analyzers Market.

Appendix Section:Here, weve stated the disclaimer, data sources, research methodology, data triangulation, market breakdown.

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Definitively, Biochemistry Analyzers report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

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The Business Strategies Accepted By Leading Players In The Biochemistry Analyzers Market | (List: Abbott Laboratories,Danaher Corporation and more) -...

Biochemistry

Global Biochemistry Analyzer Market Growth to Thrive with Technology Advancement by 2025 Dagoretti News – Dagoretti News

January 21, 2020 medical

The latest insightful research study on the Global Biochemistry Analyzer Market 2020 released byMarket Research Explorecomprises valuable comprehension of vital facets in the global Biochemistry Analyzer industry. The report carries our significant elements such as market scope, history, structure, performance, maturity, trends, and growth potential with expansive analysis. It also enlightens precise sales, revenue, demand, production, and growth rate forecasts up to 2025, which have been extracted from a thorough survey of historical and current market performance.

The global Biochemistry Analyzer market report also sheds light on the most significant factors of the market, which includes market segmentation, competitive landscape, industry environment, and leading players profiles. Additionally, the report highlights changing market dynamics, restraints, limitations, entry barriers as well as strained pricing structure, market fluctuations, variations, and growth driving forces that could possibly influence the Biochemistry Analyzer market structure in a positive/negative way. It also executes adept analytical models such as SWOT and Porters Five Forces analysis to examine vital market factors more effectively.

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Dominant contenders in the global Biochemistry Analyzer market with detailed profiles:

Various multinational Biochemistry Analyzer manufacturers and companies are operating in the market, and are striving to fulfill the overall demand for $keywords. Current rapidly evolving industrialization is prompting players to adopt effective manufacturing techniques and perform product developments, research activities, innovations in order to set strong challenges in the Biochemistry Analyzer industry and simultaneously deliver better fit products to their customers. Companies are also performing mergers, acquisitions, and partnerships as efforts to enlarge their serving area and target ample market size.

More importantly, the report offers a complete financial assessment of companies based on gross margin, Biochemistry Analyzer sales volume, financial ratios, pricing structure, production cost, product values, profitability, and revenue. It also illuminates their product specifications, raw material sourcing strategies, concentration rate of major raw material, key vendors, manufacturing base, production processes, effective technologies, production volume, distribution networks, global presence, organizational structure, and corporate alliance. The proposed analysis will help market players intuit the strengths, weaknesses, and market positions of their rivals.

Get Expansive Exploration of Global Biochemistry Analyzer Market 2020

Leading segments of the global Biochemistry Analyzer market:

The Biochemistry Analyzer types, applications, technologies, regions, and end-users are significant divisions of the market that have been intensely elaborated in the report. Each segment analysis considers its attractiveness, profitability, growth prospects, and futuristic demand. The study offers precise comprehension to market players to determine lucrative market segments for their Biochemistry Analyzer business and using appropriate business resources to maximize their gains.

Current and forthcoming market opportunities and challenges are also elucidated in the global Biochemistry Analyzer market report to assist market players to perform accordingly. Similarly, the report discovers potential market risks, obstacles, and uncertainties that could prove harmful to market growth momentum during the forecast period. Finally, the report delivers irreplaceable research conclusions that help players to build their own business and market strategies and make informed business decisions.

You can contact us at[emailprotected]in case you need detailed information or have queries regarding the market study.

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Global Biochemistry Analyzer Market Growth to Thrive with Technology Advancement by 2025 Dagoretti News - Dagoretti News

Biochemistry

Top Diet and Nutrition Issues to be Highlighted during Jan. 29 Media-only Event – Newswise

January 21, 2020 medical

MEDIA CONTACT

Available for logged-in reporters only

Newswise Nebraska food scientists are at the forefront in some of the hottest food and nutrition issues in the country the microbiome, which some predict to be one of the top nutrition issues in 2020; obesity, which continues to be a major health issue for the nation; food allergens, with the CDC reporting rising prevalence of food alelrgies in children; and food choice behavior.

On Jan. 29, a dozen researchers and scientists will be at the Food Innovation Center (1901 N. 21stSt., Lincoln, Nebraska) at Nebraska Innovation Campus to discuss their groundbreaking work with the media. The event begins at 11 a.m. with a brief overview of each research program. After a provided box lunch, media in attendance will have six 15-minute sessions to interview researchers. At 2 p.m., optional laboratory tours will be available for photos and b-roll. The event will be live-streamed for media who cannot attend in person.

Participating laboratories:

Nebraska Food for Health Center,Andy Benson, director, professor of food science and technology; Amanda Ramer-Tait, associate professor of food science and technology; and Robert Hutkins, Khem Shahani Professor of Food Science and Technology. The center is located in the Food Innovation Center, 1901 N. 21stSt., on the Nebraska Innovation Campus of the University of Nebraska-Lincoln.https://foodforhealth.unl.edu

Nebraska Center for Prevention of Obesity Diseases,Janos Zempleni, director, Cather Professor of Nutrition and Health Sciences; Jiujiu Yu, assistant professor of nutrition and health sciences; Xinghui Sun, assistant professor of biochemistry; Yongjun Wang, research assistant professor of nutrition and health sciences; Edward Harris, associate professor of biochemistry; Alice Ngu, graduate research assistant in nutrition and health sciences. The center is located at 316C Leverton Hall, 1700 N. 35thSt., on the University of Nebraska-Lincoln East Campus.https://cehs.unl.edu/npod

Food Allergy Research and Resource Program,Joseph Baumert, director, associate professor of food science and technology; Melanie Downs, assistant professor of food science and technology; Philip Johnson, assistant professor of food science and technology; and Richard E. Rick Goodman, research professor of food science and technology. The program is located in the Food Innovation Center, 1901 N. 21stSt. on the Nebraska Innovation Campus of the University of Nebraska-Lincoln.https://farrp.unl.edu

Food Choice Economics,Christopher Gustafson, associate professor of agricultural economics, 314A Filley Hall, 1625 Arbor Drive on the University of Nebraska-Lincoln East Campus.

The Food for Health Center, a $40.3 million collaboration among academics, food and drug manufacturers and philanthropists, was established in 2017 to use microbiome research to link agriculture and food production to wellness and disease prevention.

Launched in 2014, the Nebraska Center for the Prevention of Obesity Diseases has received nearly $23 million from the National Institutes of Health to determine the molecular mechanisms that lead to obesity and to identify consumer friendly remedies.

For nearly 25 years, the Food Allergy Research and Resource Program has worked in partnership with the food industry to detect and eliminate allergens in the food supply.

Behavioral economist Christopher Gustafson is identifying the hidden factors that cause people to add an extra dollop of mayo to their sandwich or select an apple, not a brownie for a post-workout snack.

Please contact Leslie Reed at 402-472-2059 orlreed5@unl.eduto reserve your space, including lunch, parking and optional lab tours.

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Top Diet and Nutrition Issues to be Highlighted during Jan. 29 Media-only Event - Newswise

Biochemistry

EXPLORER scanner captures real-time videos of blood flow and heart function – News-Medical.net

January 21, 2020 medical

Positron Emission Tomography, or PET scanning, a technique for tracing metabolic processes in the body, has been widely applied in clinical diagnosis and research spanning physiology, biochemistry, and pharmacology.

Now researchers at the University of California, Davis and Fudan University, Shanghai have shown how to use an advanced reconstruction method with an ultrasensitive total-body PET scanner to capture real-time videos of blood flow and heart function.

The work paves the way for looking at the function of multiple organs, such as the brain and heart, at the same time. The researchers published their findings Jan. 20 in the Proceedings of the National Academy of Sciences.

The project makes use of the EXPLORER PET/CT total body scanner, originally developed by a team led by Professor Simon Cherry, UC Davis Department of Biomedical Engineering and Ramsey Badawi, professor of radiology in the UC Davis School of Medicine.

A commercial version named uEXPLORER is manufactured by United Imaging Healthcare of Shanghai, and an FDA-approved model is now in clinical use at UC Davis.

The breakthrough in this work is to capture the ultrafast whole-body dynamic tracer imaging with EXPLORER at the same time. We can see global changes with improved image quality at a timescale of 100 milliseconds, which was never seen before using any medical imaging modalities."

Jinyi Qi, professor of biomedical engineering, UC Davis

Qi and project scientist Xuezhu Zhang developed methods to reduce noise and reconstruct images from the raw data from EXPLORER scans of volunteers. They were able to see changes on a scale of 100 milliseconds, or one-tenth of a second and use these to create high quality real-time movies of the scans.

In a scan shown in the paper, a volunteer was injected in the lower leg with a short-lived radioactive tracer (PET scans work by following radioactive tracers in the body). The resulting video shows the tracer moving up the body to the heart, flowing through the right ventricle to the lungs, back through the left ventricle and on to the rest of the body.

"It's a combination of the scanner and advanced data reconstruction methods that makes this possible. This has applications in real-time tracking of blood flow over the human circulatory system, motion-frozen heart beating and breathing monitoring for cardiovascular and cerebrovascular disease and analysis of respiratory system function," Zhang said.

The video shows the motion of the heart with exceptional clarity. Changes in the cardiac contraction are well captured with clear delineation of the end-systolic and end-diastolic phases. While other techniques are available to measure heart function, EXPLORER's full-body scans provide opportunities for new studies that look at the dynamic function of multiple organs, such as the brain and heart, at the same time.

The scan shown in the paper was conducted at United Health Imaging and supervised by Zhongshan Hospital, Shanghai. The researchers are continuing to collect images from volunteers at UC Davis.

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EXPLORER scanner captures real-time videos of blood flow and heart function - News-Medical.net

Biochemistry

Postdoc Position, Department of Biology job with MASARYK UNIVERSITY | 193197 – Times Higher Education (THE)

January 21, 2020 medical

POSTDOC POSITION in Characterization of factors involved in metabolism of stalled replication forks and their possible disease relevance

Department Department of BiologyFaculty of Medicine

Deadline 29 Feb 2020

Start date March/April 2020 or upon agreement but no later than by 30th November 2020

Masaryk University, Brno, Czech Republic invites excellent scientists to apply for POSTDOC POSITION in Characterization of factors involved in metabolism of stalled replication forks and their possible disease relevance

Description:

The integrity of DNA continually resists the presence of physical and chemical carcinogens in our environment. In addition to exogenous agents, DNA undergoes spontaneous decay, including replication errors, oxidative and other damages which arise from common metabolic processes. The repair of damaged DNA is vital for the maintenance of genome integrity, and as aresult, all organisms have evolved awide variety of DNA repair pathways that can restore DNA structure and its genetic information.

The main objective of our research is to decipher the intrinsic functions of homologous recombination (HR) which has adual role in the maintenance of genome stability. First, it promotes the faithful repair of DNA double-strand breaks (DSBs) belonging among of the most lethal forms of DNA damage. Moreover, HR is responsible for the creation of genetic variability during meiosis by directing the formation of reciprocal crossovers that result in random combinations of alleles and traits. Changes in the execution and regulation of recombination are linked to human infertility, miscarriage and genetic diseases, particularly cancer thus emphasizing the importance of better understanding the mechanism and regulation of this pathway.

To achieve our goals, we utilize awide range of different methods from biochemistry, molecular biology, genetics, structural biology, and biophysics that are well established in our lab. Since we believe that interdisciplinary approach is needed to fully understand the fundamental biological processes, we also collaborate with numerous specialists.

The successful candidate should:

Specific criteria can be filled, i.e.:

The application should include:

MU offers the opportunity to get:

Anticipated start date:The position is available from March/April 2020 or upon agreement but no later than by 30th November 2020.

The submission deadline is29th February 2020.

Please submit your application by e-mail tovrablikova@med.muni.cz

Areview of applications will commence immediately after the deadline. Short-listed candidates will be invited for interview within one month of the deadline.

Further information about:

prof. MUDr. Martin Repko, Ph.D.dkan

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Postdoc Position, Department of Biology job with MASARYK UNIVERSITY | 193197 - Times Higher Education (THE)

Biochemistry

UHS approves affiliation of 29 institutes – The News International

January 21, 2020 medical

UHS approves affiliation of 29 institutes

LAHORE: The syndicate of University of Health Sciences (UHS) has approved the affiliation of 29 institutes for start of 56 new postgraduate and undergraduate programmes.

The 58th meeting of UHS Syndicate was held here on Monday with Vice Chancellor Prof Javed Akram in the chair. The other members who were present included Prof Talat Naseer Pasha, Prof Khawaja Sadiq Hussain, Prof Humaira Akram, Prof Nadia Naseem, Prof Nasir Shah, Dr Asad Zaheer and representatives of Punjab Specialized Healthcare and Medical Education (SHC&ME) and Finance departments.

The syndicate approved affiliation, extension in affiliation and enhancement of seats in various institutions after considering inspection reports of the affiliation committee. It approved Doctor of Medicine (MD) in the disciplines of psychiatry, radiology, gastroenterology, nephrology, cardiology, medicine, and paediatrics to be offered in different public sector institutions of the province.

Similarly, recommendations of the affiliation committee were approved for start of Master of Surgery (MS) in cardiac surgery, ophthalmology, neurosurgery, urology, and paediatric surgery.

The body also approved BSc programmes in the disciplines of nursing, Doctor of Physical Therapy (DPT), medical laboratory technology, dental technology, dental hygiene, nutrition, cardiac perfusion, medical imaging technology, orthotics and prosthetics, optometry and Orthoptics, and audiology to be started in different public and private sector institutions of Punjab.

Moreover, approval was also granted for start of MPhil Biochemistry, MSc Nursing, Diploma in Anaesthesia, and Diploma in Child Health.

The syndicate also approved the recommendations of MD/MS/MDS Reforms Committee to conduct intermediate examination on completion of 18 months of training rather than 24 months.

The policy of negative marking was also abolished for both intermediate and abridged examination in all disciplines in Central Induction Policy (CIP) scheme of MD/MS/MDS programmes.

It was also decided that the candidates who would pass written component of an examination in MD/MS/MDS, but fail in clinical and oral component, would be allowed a maximum of three attempts to clear clinical and oral component of that examination, failing which they would have to take the entire examination, including written component, afresh.

The syndicate also endorsed the VCs proposal to invite online applications for grant of affiliation in future besides creation of a dedicated directorate of affiliation in the University to deal with matters related to affiliation.

The members also approved award of PhD degree to Dr Rabiea Munir in the subject of pharmacology.

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UHS approves affiliation of 29 institutes - The News International

Biochemistry

Science Talk – Tell me more about telomeres: how ‘basic’ science can help us treat cancer – The Institute of Cancer Research

January 21, 2020 medical

Image: Chromosomes and their telomeres (visualised in red). Credit: Thomas Ried, NCI Center for Cancer Research

You might not have heard of telomeres but theyre incredibly important they are the caps that protect the end of chromosomes. They work like the plastic tips that stop your shoelaces from fraying.

All cancers alter telomeres in order to survive, so by doing basic research to try to understand how telomere replication and processing works, Max and his team hope to identify possible new ways to target and treat cancer.

Having joined the Division of Cancer Biology in October 2019, Dr Max Douglasis now one of the newest Team Leaders at the ICR. I met him at our Chester Beatty Laboratories in Chelsea, where he told me more about his work.

Max studied for his PhD in biochemistry and cell biology at the University of Cambridge. He then joined Dr John Diffleys team in Londons Clare Hall Laboratories which later became part of the Francis Crick Institute where he focused on studying the early stages of DNA replication.

At the Crick, he helped establish in detail how a protein complex called the CMG replicative helicase that helps unwind DNA during replication, is assembled and activated.

Now at the ICR, Max leads his own research team studying DNA replication but in the context of telomeres and cancer.

My main project is to rebuild telomeres in the lab and then unpick how they work how they are replicated and how they are processed. This knowledge is generally useful, but we will focus on studying it in the context of cancer, explained Max.

Lets finish it:help us revolutionise cancer treatment. We aim to discover a new generation of cancer treatments so smart and targeted, that more patients will defeat their cancer and finish what they started.

Support our work

When a cell becomes cancerous, it divides more often and every time it divides, its telomeres become shorter and shorter. Once there is no telomere left, the DNA unravels, like a shoelace fraying, and the cell dies. This eventually happens in most healthy cells telomeres shorten over time until cell division is no longer possible, leading to cell death.

While this loss of telomere protection can cause cancer cells and healthy cells to die, it can also lead to a state of genome instability that helps cancer survive and spread.

We also know that cancer cells can escape death by making telomerase, an enzyme that prevents telomeres from getting short. Certain cells in our body, such as stem cells, are able to divide over and over again thanks to telomerase. Cancer cells take advantage of this enzyme and hijack it to maintain telomere length which enables them to continue to divide and spread.

In other words, telomeres seem to play a role in the death of cancer cells but theyre also crucial for their survival. However, the molecular steps that guide telomere replication and processing remain poorly understood.

By using genetics and replicating cellular processes in a test tube, through a technique known as reconstitution biochemistry, Max and his team hope to better understand how telomeres are processed, and how they are inherited from one generation of cells to the next.

If Max and his team can dissect how telomeres work and clarify their link to cancer, maybe well figure out new ways to treat it.

His research might seem quite distant from the clinic, but Max knows he belongs at the ICR, which has an exemplary track record in making discoveries that ultimately benefit people with cancer.

I really value the ICRs commitment to doing basic, laboratory science. Good basic science is necessary to understand cancer, and the ICR values that. Here, I can figure out how to use my findings to benefit people, and that, in turn, will also hugely benefit my work, Max said.

I feel very lucky to work at an institution with a mission, being able to do what I love while getting opportunities to make discoveries that could help people.

As a new Team Leader, Max is currently the only member of his team but a higher scientific officer will be joining this month, as well as a post-doctoral training fellow, who will be joining in March. They will also start recruiting for a PhD student. As he told me, he cant wait for the new team members to join him in January.

Im excited to supervise other people for the first time. I want to build a strong team and a good environment for them to thrive in.