Category Archives: Biochemistry

Biochemistry

Itaconic Acid Market Incredible Possibilities, Growth Analysis and Forecast To 2025 |Alpha Chemika, Chengdu Jinkai Biology Engineering, Itaconix…

Overview Of Itaconic Acid Industry 2020-2025:

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

The Itaconic Acid Market analysis summary by Reports Insights is a thorough study of the current trends leading to this vertical trend in various regions. Research summarizes important details related to market share, market size, applications, statistics and sales. In addition, this study emphasizes thorough competition analysis on market prospects, especially growth strategies that market experts claim.

Itaconic Acid Market competition by top manufacturers as follow: , Alpha Chemika, Chengdu Jinkai Biology Engineering, Itaconix Corporation, Jinan Huaming Biochemistry, Shandong Zhongshun Science & Technology Development, Spectrum Chemical, Zhejiang Guoguang Biochemistry, Nanjing Huajin Biologicals, Qingdao Langyatai Group, Qingdao Kehai Biochemistry, Ronas Chemicals, Shandong Kaison Biochemical,

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The global Itaconic Acid market has been segmented on the basis of technology, product type, application, distribution channel, end-user, and industry vertical, along with the geography, delivering valuable insights.

The Type Coverage in the Market are: SynthesisFermentation

Market Segment by Applications, covers:PlasticizerLubricating Oil AdditiveOthers

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Major factors covered in the report:

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The analysis objectives of the report are:

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Itaconic Acid Market Incredible Possibilities, Growth Analysis and Forecast To 2025 |Alpha Chemika, Chengdu Jinkai Biology Engineering, Itaconix...

Biochemistry

CSU-SACNAS working to create inclusive community in STEM – College of Natural Sciences – Source

Taking a leadership role

Ricardo Vazquez, a fifth-year CSU student double majoring in biochemistry and molecular biology and biomedical science, is this years SACNAS president. He has been involved with the club since 2018 and joined immediately after transferring from Aims Community College in Greeley.

What drew him to the club, initially, was diversity.

Not everybody in SACNAS identifies as Chicano or is Hispanic or Native American, said Vazquez who identifies as Chicano and is a first-generation student. I really like the community because its not a student organization dedicated to promoting just one under-represented minority, it is an enginWoverarching student organization dedicated to promoting diversity in STEM by allowing underrepresented students the opportunity to have an impact in both their scientific and cultural communities.

Vazquez added: I never thought Id be the president of a student organization I never even thought Id be centered in anything. I really didnt have a community back at my old school. I came to CSU looking to be part of a community, and SACNAS really allowed me to do that. Now, the club is allowing me to take a leadership role, trying to grow it and get everybody take part in the community.

SACNAS has a robust group of advisors, faculty board members, and long-term members who are passionate about science and fostering the success of all people in STEM.

Vazquez added that being part of a community of support has been a tremendous asset, adding that SACNAS is a hub for rewarding mentorship opportunities.

Building a community that empowers us and allows us to ask for help and ask questions and be mentors for each other is really important, because you dont know what you dont know, and there are people in our community that do know and want to help, Vazquez said.

Vazquez found SACNAS through Paul Laybourn, a professor in the Department of Biochemistry and Molecular Biology and advisor for the club.

Diversity and inclusion are the biggest issues in science today, Laybourn said. They are a bigger problem than funding. Diversity and inclusion affect science. Its a national security issue. If you dont have all ideas and minds at the table how can you be prepared to solve problems, to answer questions?

While SACNAS was initially meant to bring representation to a few minority groups, it has evolved to become inclusive of all minoritized groups in STEM.

We want everyone to succeed, Vazquez said. SACNAS main goal is getting students more involved in research so that they can understand fundamentally what its like to be a researcher, Laybourn said. We also seek to create a scientific community that doesnt ask you to adopt a new culture but rather introduce your culture to your research.

SACNAS is also diverse in the disciplines of science it represents. It allows students to speak to each other about their research, which teaches them to communicate about their work outside of their direct field, which is a huge skill, said Shane Kanatous, the SACNAS faculty advisor and Department of Biology professor.

While CSU has many different administrative and student efforts focused on diversity and inclusion, SACNAS is somewhat unique. Everyone in science is big on research, but not everyone is big on diversity and inclusion, said CSU student Vincent Elias, a neuroscience major and the public and marketing relations officer for SACNAS.

This semester, all SACNAS events and meetings will be completely virtual. The club leaders have developed We Hear You, Lets Talk About It, a virtual meeting series in response to the COVID-19 pandemic that provides a safe space for community members designed to foster discourse and support.

According to the organizers, the first few iterations of the meeting have been very successful, and the club leadership is looking forward to growing the community, even in a virtual format.

The club has also taken the time to develop a statement of commitment: To promote diversity within STEM with careful consideration of the Black Lives Matter movement and incidents of racial bias both on and off CSUs campus.

The action we take on campus will prepare us to take action off campus, said Vazquez.

This years SACNAS student leaders give proof that the organization is deeply committed to its mission, and ready to make change at CSU, in STEM, and around the world.

About Rams Shape Science:Meet some of the extraordinary students, faculty, and staff in the College of Natural Sciences who are shaping the future of science and our society.

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CSU-SACNAS working to create inclusive community in STEM - College of Natural Sciences - Source

Biochemistry

Global Biochemical Diagnostic Reagent Market Insights and Forecast 2020 to 2025 – The Daily Chronicle

This report additionally covers the effect of COVID-19 on the worldwide market. The pandemic brought about by Coronavirus (COVID-19) has influenced each part of life all inclusive, including the business segment. This has brought along a several changes in economic situations.

The Biochemical Diagnostic Reagent market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, impact of domestic and global market players, value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

It incorporates Biochemical Diagnostic Reagent market evolution study, involving the current scenario, growth rate (CAGR), and SWOT analysis. Important the study on Biochemical Diagnostic Reagent market takes a closer look at the top market performers and monitors the strategies that have enabled them to occupy a strong foothold in the market. Apart from this, the research brings to light real-time data about opportunities that will completely transform the trajectory of the business environment in the coming years to 2025. Some of the key players in the global Biochemical Diagnostic Reagent market is cccc

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According to 99Strategy, the Global Biochemical Diagnostic Reagent Market is estimated to reach xxx million USD in 2020 and projected to grow at the CAGR of xx% during the 2021-2026. The report analyses the global Biochemical Diagnostic Reagent market, the market size and growth, as well as the major market participants.

The analysis includes market size, upstream situation, market segmentation, market segmentation, price & cost and industry environment. In addition, the report outlines the factors driving industry growth and the description of market channels.The report begins from overview of industrial chain structure, and describes the upstream. Besides, the report analyses market size and forecast in different geographies, type and end-use segment, in addition, the report introduces market competition overview among the major companies and companies profiles, besides, market price and channel features are covered in the report.

Key Regions

Asia Pacific

North America

Europe

South America

Middle East & Africa

Key Companies

Roche

Siemens Healthineers

Beckman Coulter

Randox

BioSino

Beijing Leadman Biochemistry

FosunPharma

Beijing Strong Biotechnologies

Dojindo Laboratories

Sysmex

KAINOS Laboratories

DAAN Gene

Key Product Type

Liquid Double Reagent

Dry Powder Double Reagent

Market by Application

Hospital

Clinic

Laboratory

Main Aspects covered in the Report

Overview of the Biochemical Diagnostic Reagent market including production, consumption, status & forecast and market growth

2016-2020 historical data and 2021-2026 market forecast

Geographical analysis including major countries

Overview the product type market including development

Overview the end-user market including development

Impact of Coronavirus on the Industry

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Major Point of TOC:

Chapter One: Biochemical Diagnostic Reagent Market Overview

Chapter Two: Biochemical Diagnostic Reagent Market Segment Analysis by Player

Chapter Three: Biochemical Diagnostic Reagent Market Segment Analysis by Type

Chapter Four: Biochemical Diagnostic Reagent Market Segment Analysis by Application

Chapter Five: Biochemical Diagnostic Reagent Market Segment Analysis by Sales Channel

Chapter Six: Biochemical Diagnostic Reagent Market Segment Analysis by Region

Chapter Seven: Profile of Leading Biochemical Diagnostic Reagent Players

Chapter Eight: Upstream and Downstream Analysis of Biochemical Diagnostic Reagent

Chapter Nine: Development Trend of Biochemical Diagnostic Reagent (2020-2029)

Chapter Ten: Appendix

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Global Biochemical Diagnostic Reagent Market Insights and Forecast 2020 to 2025 - The Daily Chronicle

Biochemistry

Increase In Frequency Of Product Innovations To Drive The Biochemistry Analyser Market From 2024 – The Daily Chronicle

Market Size US$ 4,700 Mnin 2024, Market Growth CAGR of 5.5%, Market Trends Growing prevalence ofHealthcare Industry

The clinical use of biochemistry analyzers in measurement solutions such as latex agglutination, ion-selective potentiometry, and colorimetric & photometric testing. In addition to this, accuracy of biochemistry analyzers in analyzing blood and urine samples has benefited pathology labs and diagnostic centers across the globe. Persistence Market Research predicts that the global demand for biochemistry analyzers will continue to soar on the grounds of such factors.

A recent report published by Persistence Market Research projects that by the end of 2024, the global market for biochemistry analyzers will reach US$ 4,625.3 Mn in terms of value.

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Company Profiles

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Key findings in the report cite that the use of chemistry analyzers spans from high-throughput clinical labs to point-of-care clinics, and its use for testing enzymes, electrolytes and proteins is gaining traction.

The report current values the globalbiochemistry analyzer marketat a little over US$ 3,000 Mn. During the forecast period, revenues generated through global sales of biochemistry analyzers are, thus, expected to soar at a steady CAGR of 5.5%.

Key Research Insights from the Report include:

The global market for biochemistry analyzers represents absolute $ opportunity of US$ 154.6 Mn in 2017 over 2016 and incremental opportunity of US$ 1,570.8 Mn between 2016 and 2024

Apart from clinical diagnostics, critical applications of biochemistry analyzers include drugs-of-abuse testing and diagnostic testing of patients metabolic functions

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Over 40% of biochemistry analyzers sold across the globe during the forecast period will be concentrated in North America

Demand for biochemistry analyzers is also expected to surge in Asia-Pacific, revenues from which will record steadfast growth at 6.1% CAGR

Leading manufacturers of biochemistry analyzers are developing multiplexing analyzers a cost-effective upgrade to existing product line

The report further reveals that fully-automated biochemistry analyzers will remain in great demand in the years to come. In 2017 and beyond, more than 85% of global biochemistry analyzer revenues will be accounted by sales of fully-automated biochemistry analyzers.

Moreover, clinical diagnostics will also remain the largest application of biochemistry analyzers throughout the forecast period. Revenues accounted by global sales of biochemistry analyzers in clinical diagnostics are anticipated to register speedy growth at 5.7% CAGR.

The report further identifies diagnostic centers as largest end-users of biochemistry analyzers in the world. On the other hand, rising number of point-of-care diagnostic labs instated in hospitals will render a key end-user of biochemistry analyzers. Together, hospitals and diagnostics centers will be responsible for procure over two-third of global biochemistry analyzers revenues through 2024.

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Persistence Market Research (PMR) is a third-platform research firm. Our research model is a unique collaboration of data analytics and market research methodology to help businesses achieve optimal performance.

To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

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Increase In Frequency Of Product Innovations To Drive The Biochemistry Analyser Market From 2024 - The Daily Chronicle

Biochemistry

Department of Energy Awards $1M to CU Denver-Led Team for Computational Biology – CU Denver News

The U.S. Department of Energy (DOE) announced $5 million in funding for six new research projects in computational biology, $1,049,639 of which goes to Chris Miller, associate professor in CU Denvers Department of Integrative Biology, and his collaboratorsFarnoush Banaei-Kashani from CU Denver, Kelly Wrighton from CSU, and Chris Henry from DOE.

Millers project, titled Finding the Missing Pieces: Filling Gaps that Impede the Translation of Omics Data into Models, seeks to develop novel computational biology approaches and software to better understand microbial genomes relevant to the environment. According to Miller, there are parallels to studying the human microbiome in many challenges we see todayclimate change, bioenergy-relevant systems, and more.

Take, for example, a freshwater wetland system in Ohio. Miller and his colleagues studied this model for years because microbes in the soil of freshwater wetlands naturally emit the greenhouse gas methane. All that said, we know relatively little about the controls on this microbial process or how changing climate or land-use practices might affect emissions.

There are thousands of different types of microbes (bacteria, fungi, etc.) living in even just a pinch of this soil, Miller said. But we have no clue how to grow and study most of them in the lab, so DNA sequencing and computation give us the ability to extract DNA directly from soil, sequence the bits of genome we recover, and then computationally try to piece the original genomes back together.

The reason this matters? Miller notes by following this process, we are able to actually predict which proteins those genomes encode and infer what the microbes might be doing in the environment.

In some of these complex soils, we are discovering novel organismslots of themand the genes we are sequencing often look nothing like scientists have characterized in the lab before, Miller said. New computational approaches are needed to infer microbial biochemistry and metabolism from the DNA so we can better understand and predict microbial roles in the larger ecosystems.

By developing new algorithms and software for analyzing microbial genomes recovered from the environment, Miller and his team will develop and scale new computational methods to infer functions for genes. This will be integrated into a DOE computational biology system called KBase so scientists all over the world can utilize their methods to more efficiently figure out what proteins and genomes are doing in their systems of interest.

This project is exciting because it is foundational to answering so many different kinds of questions, said Miller. Biology is increasingly Big Data science, and we need to make sure we have the computational tools to keep up with the data generation Our collaborators on this project are world-class, and I feel grateful that CU Denver students and I will have the chance to work with and learn from this team to advance the science.

Related Research: Genetic Adaptation to Climate Change Is Swift in Crop Pests

Awards were selected based on competitive peer review under a DOE Funding Opportunity Announcement issued by the Office of Biological and Environmental Research (BER) within DOEs Office of Science. Total funding is $5 million in Fiscal Year 2020 dollars, for projects up to three years in duration.

A list of projects can be found on the BER homepage under the heading, Whats New.

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Department of Energy Awards $1M to CU Denver-Led Team for Computational Biology - CU Denver News

Biochemistry

Scientist takes a closer look at the genome – University of Miami

With a $1.82 million grant, computer scientist and bioinformatic researcher Zheng Wang is poised to help researchers see every aspect of the genome in super-resolution 3D.

Breakthrough advances in biomedical technology have come a long way, especially with three-dimensional mapping of the structure of the genome. For years, scientists and researchers have attempted to obtain and analyze the entire 3D structure of an organism's DNA to observe and understand its complex organization and how the genes function and interact.

Now, by combining cutting-edge computer science techniqueswith leading biomedical technologies, computer scientist and bioinformatic researcher Zheng Wang ispoised to help researchers see every aspect of the genome in super-resolution 3D formalmost an impossibility through the microscopeto better interpret its biological meaning.

Wang, who specializes in bioinformatics research, an interdisciplinaryfield combining biology, statistics, and computer science, recently received a five-year, $1.82 million Maximizing Investigators' Research Award (MIRA), considered one of the most prestigious National Institutes of Health grants for outstanding investigators, to develop more complex computational algorithms that will enable closer looks at the 3D genome.

"This is very exciting news, said Wang. This award will help me develop a new 3D perspective for studying the genome. Over the next five years, I hope to develop computational algorithms toreconstruct the 3D genome structures of single cells and builddeep-learning algorithms toenhance the resolution of whats known as Hi-C, the biochemistry experiment for detecting spatial proximity between different parts of the genome.

Although Wang is the sole principal investigator of the award, he said he cannot do his work without collaborators. He already has enlisted the help of Miller School of Medicine neuroscientists Vance Lemmon and John Bixby. Their lab is providing samples of mouse genomes to help Wang examine the changes of the 3D genome structures during the regenerative process of damaged neuron cells.

The scientist is also using Hi-C data generated by other biochemistry labs that use human brain, liver, spleen, stomach, and cancer cells. Neither a computer program nor the Hi-C experiment can directly detect the 3D genome structure. But a biochemical wet lab can provide the cells, or Hi-C data, that will enable me to create the intelligent algorithms to build the 3D genome structures and then analyze them very, very closely, Wang explained.

The award also will help Wang answer scientific questions on how the structure of the genome influences gene regulation and other important biological processes of the cells, as well as the role of the long non-coding RNAs in the formation of genome structures.

The scientific question that fascinates me is why the 3D genomestructures are different and what consequences these differences will lead to, said Wang. With this award, I hope to answer fundamental and biological questions that can then be used when studying the genome. One of my goals is to help other scientists develop further research so that they can go deeper into the genome and be able to study specific diseases.

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Scientist takes a closer look at the genome - University of Miami

Biochemistry

Postdoctoral studies on the molecular mechanisms that regulate aging – Nature.com

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including aging, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, bioorganic chemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 250 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Do you want to contribute to top quality medical research?

Aging is one of the main risk factors for morbidity and mortality. Thus, a better understanding of the mechanisms that regulate this process is highly desirable. One of our efforts focuses on arguably the most important aging regulator known to date, the transcription factor DAF-16/FOXO. It resides downstream of the nutrient-sensing insulin/IGF signaling pathway and in response to low nutrients activates gene expression programs that slow down the aging process. DAF-16/FOXO depends on a diverse range of binding partners and regulators to fulfill its role, and we are studying their functions by diverse biochemical, genetic, and cytological techniques. (See Lin et al., Nature Communications 2018, or Sen et al., Nature Communications 2020, for examples of such work from our lab.)

Your mission

We are looking for a Postdoc to join our research group, the lab of Christian Riedel. Focus of this position is to explore a new binding partner of DAF-16/FOXO which we found to be required for DAF-16/FOXO to promote longevity in response to low nutrient signals. This work is conducted both in the model organism C. elegans and in human cells. You will synergize with aging biologists and bioinformaticians from the Riedel lab and be part of a larger aging-focused research environment at our department, which also contains the labs of Martin Berg and Maria Eriksson.

We are looking for a talented and highly motivated scientist with a doctoral degree and strong background in Molecular Biology, Cell Biology, Genetics, and/or Biochemistry. Good expertise in either C. elegans methods or in mammalian cell culture techniques is desired. Also, a background in the biology of aging is appreciated, even though it is not essential.

Applicants are expected to work independently but as part of an enthusiastic team and to be proficient in English. They are expected to play a leading role in the design and execution of their experiments as well as the analysis and the presentation/publication of the resulting data. Before and while being in the lab, the applicant will be encouraged to apply for competitive national and international postdoctoral fellowships and career grants and will receive support in those endeavors.

This position will be financed by a postdoc scholarship paid out by Karolinska Institutet.

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the worlds leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden.

Location: Department of Biosciences and Nutrition, Neo Building, Flemingsberg

Links: https://ki.se/en/bionut/department-of-biosciences-and-nutrition https://ki.se/en/bionut/christian-riedel-group http://riedellab.org/

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

An application must contain the following documents in English:

You are welcome to apply at the latest by 16 October 2020.

The application has to be submitted through the Varbi recruitment system.

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Postdoctoral studies on the molecular mechanisms that regulate aging - Nature.com

Biochemistry

UK research getting to bottom of COVID clots – ABC 36 News – WTVQ

The research led by Jeremy Wood, Zach Porterfield and Jamie Sturgill in the Department of Internal Medicine; Beth Garvy in Microbiology, Immunology & Molecular Genetics; and Wally Whiteheart in Molecular & Cellular Biochemistry, suggests localized inflammation in the lungs caused by COVID-19 may be responsible for the increased presence of blood clots in patients.

The study also provides evidence suggesting the risk of thrombosis could persist after the infection clears.

The study examined the blood of 30 COVID-19 patients including 15 who were inpatients in the intensive care unit, and 15 who received care as outpatients at UKs Infectious Diseases Clinic, along with eight disease-free volunteers who acted as a control group.

Compared to baseline, the COVID-19 patients had elevated levels of tissue factor, a protein found in blood that initiates the clotting process. Patients also had reduced levels of protein S, an anticoagulant that helps prevent blood clotting.

The researchers concluded that lung inflammation caused by COVID-19 is what leads to a decrease in protein S. Thisinflammation also causes immune and possible endothelial cell activation, which leads to increased tissue factor protein.

What weve learned is that the clotting is not caused by anything systemic. Localized inflammation in the lungs is whats driving this whole process, Wood said. With an increase in tissue factor and a deficiency in protein S, COVID-19 patients get more blood clotting without the ability to shut it down or control it.

The study additionally showed that protein S levels remained low in some patients even after they tested negative for COVID-19, which suggests that blood clotting issues may persist after infection and long-term monitoring of thrombotic risk may be necessary.

Wood says this preliminary data could be a cause for concern. Certain viruses like HIV are linked to a long-term deficiency in protein S, which causes an ongoing risk of thrombosis in patients. It is not yet known if COVID-19 could cause a similar persisting protein S deficiency.

Tissue factor and protein S are good markers to monitor for long-term thrombosis risk and the data suggest that we need to be monitoring these patients because were not seeing these parameters corrected immediately, Wood said.

The research team recently received a grant from UKsCenter for Clinical and Translational Science(CCTS) to begin a longitudinal study to look at these levels in patients over the next year.

This will help answer the question: will this risk remain like it is in the HIV patients or will it go away?

The study was funded in part by anAlliance Grantthrough the College of Medicine as well as UKsCOVID-19 Unified Research Experts (CURE) Alliancethroughthe Vice President for Research and the College of Medicine and the CCTS. It was a product of collaboration between a number of different groups at UK that have been studying COVID-19.

Additional collaborators includeMartha Sim, Meenakshi Banerjee and Hammodah Alfar in the Department of Molecular and Cellular Biochemistry; Melissa Hollifield and Jerry Woodward with Microbiology, Immunology and Molecular Genetics; Xian Li with the Saha Cardiovascular Research Center; Alice Thornton with the Division of Infectious Disease; and Gail Sievert, Marietta Barton-Baxter and Kenneth Campbell with CCTS.

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UK research getting to bottom of COVID clots - ABC 36 News - WTVQ

Biochemistry

Global Blood Cell Analyzer Industry – Yahoo Finance

Global Blood Cell Analyzer Market to Reach $2. 1 Billion by 2027. Amid the COVID-19 crisis, the global market for Blood Cell Analyzer estimated at US$1. 5 Billion in the year 2020, is projected to reach a revised size of US$2.

New York, Sept. 15, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Blood Cell Analyzer Industry" - https://www.reportlinker.com/p05960820/?utm_source=GNW 1 Billion by 2027, growing at aCAGR of 4.8% over the period 2020-2027. Semi-automated Biochemistry Analyzers, one of the segments analyzed in the report, is projected to record 4.5% CAGR and reach US$539.5 Million by the end of the analysis period. After an early analysis of the business implications of the pandemic and its induced economic crisis, growth in the Fully Automated Biochemistry Analyzers segment is readjusted to a revised 4.9% CAGR for the next 7-year period.

The U.S. Market is Estimated at $439.7 Million, While China is Forecast to Grow at 4.5% CAGR

The Blood Cell Analyzer market in the U.S. is estimated at US$439.7 Million in the year 2020. China, the world`s second largest economy, is forecast to reach a projected market size of US$366.3 Million by the year 2027 trailing a CAGR of 4.5% over the analysis period 2020 to 2027. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at 4.6% and 3.8% respectively over the 2020-2027 period. Within Europe, Germany is forecast to grow at approximately 4% CAGR.We bring years of research experience to this 8th edition of our report. The 277-page report presents concise insights into how the pandemic has impacted production and the buy side for 2020 and 2021. A short-term phased recovery by key geography is also addressed.

Competitors identified in this market include, among others,

Read the full report: https://www.reportlinker.com/p05960820/?utm_source=GNW

I. INTRODUCTION, METHODOLOGY & REPORT SCOPE

II. EXECUTIVE SUMMARY

1. MARKET OVERVIEW Global Competitor Market Shares Blood Cell Analyzer Competitor Market Share Scenario Worldwide (in %): 2019 & 2025 Impact of Covid-19 and a Looming Global Recession

2. FOCUS ON SELECT PLAYERS

3. MARKET TRENDS & DRIVERS

4. GLOBAL MARKET PERSPECTIVE Table 1: World Current & Future Analysis for Blood Cell Analyzer by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 2: World Historic Review for Blood Cell Analyzer by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 3: World 15-Year Perspective for Blood Cell Analyzer by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets for Years 2012, 2020 & 2027

Table 4: World Current & Future Analysis for Semi-automated Biochemistry Analyzers by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 5: World Historic Review for Semi-automated Biochemistry Analyzers by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 6: World 15-Year Perspective for Semi-automated Biochemistry Analyzers by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 7: World Current & Future Analysis for Fully Automated Biochemistry Analyzers by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 8: World Historic Review for Fully Automated Biochemistry Analyzers by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 9: World 15-Year Perspective for Fully Automated Biochemistry Analyzers by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 10: World Current & Future Analysis for Bench-top by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 11: World Historic Review for Bench-top by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 12: World 15-Year Perspective for Bench-top by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 13: World Current & Future Analysis for Floor-standing by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 14: World Historic Review for Floor-standing by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 15: World 15-Year Perspective for Floor-standing by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 16: World Current & Future Analysis for Clinical Diagnostics by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 17: World Historic Review for Clinical Diagnostics by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 18: World 15-Year Perspective for Clinical Diagnostics by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 19: World Current & Future Analysis for Drug development by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 20: World Historic Review for Drug development by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 21: World 15-Year Perspective for Drug development by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 22: World Current & Future Analysis for Other Applications by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 23: World Historic Review for Other Applications by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 24: World 15-Year Perspective for Other Applications by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 25: World Current & Future Analysis for Hospitals by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 26: World Historic Review for Hospitals by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 27: World 15-Year Perspective for Hospitals by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 28: World Current & Future Analysis for Diagnostic Centers by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 29: World Historic Review for Diagnostic Centers by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 30: World 15-Year Perspective for Diagnostic Centers by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 31: World Current & Future Analysis for Pharmaceutical Companies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 32: World Historic Review for Pharmaceutical Companies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 33: World 15-Year Perspective for Pharmaceutical Companies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 34: World Current & Future Analysis for Biotechnology Companies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 35: World Historic Review for Biotechnology Companies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 36: World 15-Year Perspective for Biotechnology Companies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 37: World Current & Future Analysis for Contract Research Organizations by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 38: World Historic Review for Contract Research Organizations by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 39: World 15-Year Perspective for Contract Research Organizations by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

Table 40: World Current & Future Analysis for Academic Research Institutes by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2020 through 2027

Table 41: World Historic Review for Academic Research Institutes by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 42: World 15-Year Perspective for Academic Research Institutes by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2012, 2020 & 2027

III. MARKET ANALYSIS

GEOGRAPHIC MARKET ANALYSIS

UNITED STATES Market Facts & Figures US Blood Cell Analyzer Market Share (in %) by Company: 2019 & 2025 Market Analytics Table 43: USA Current & Future Analysis for Blood Cell Analyzer by Product Type - Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 44: USA Historic Review for Blood Cell Analyzer by Product Type - Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 45: USA 15-Year Perspective for Blood Cell Analyzer by Product Type - Percentage Breakdown of Value Sales for Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers for the Years 2012, 2020 & 2027

Table 46: USA Current & Future Analysis for Blood Cell Analyzer by Modality - Bench-top and Floor-standing - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 47: USA Historic Review for Blood Cell Analyzer by Modality - Bench-top and Floor-standing Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 48: USA 15-Year Perspective for Blood Cell Analyzer by Modality - Percentage Breakdown of Value Sales for Bench-top and Floor-standing for the Years 2012, 2020 & 2027

Table 49: USA Current & Future Analysis for Blood Cell Analyzer by Application - Clinical Diagnostics, Drug development and Other Applications - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 50: USA Historic Review for Blood Cell Analyzer by Application - Clinical Diagnostics, Drug development and Other Applications Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 51: USA 15-Year Perspective for Blood Cell Analyzer by Application - Percentage Breakdown of Value Sales for Clinical Diagnostics, Drug development and Other Applications for the Years 2012, 2020 & 2027

Table 52: USA Current & Future Analysis for Blood Cell Analyzer by End-Use - Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 53: USA Historic Review for Blood Cell Analyzer by End-Use - Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 54: USA 15-Year Perspective for Blood Cell Analyzer by End-Use - Percentage Breakdown of Value Sales for Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes for the Years 2012, 2020 & 2027

CANADA Table 55: Canada Current & Future Analysis for Blood Cell Analyzer by Product Type - Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 56: Canada Historic Review for Blood Cell Analyzer by Product Type - Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 57: Canada 15-Year Perspective for Blood Cell Analyzer by Product Type - Percentage Breakdown of Value Sales for Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers for the Years 2012, 2020 & 2027

Table 58: Canada Current & Future Analysis for Blood Cell Analyzer by Modality - Bench-top and Floor-standing - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 59: Canada Historic Review for Blood Cell Analyzer by Modality - Bench-top and Floor-standing Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 60: Canada 15-Year Perspective for Blood Cell Analyzer by Modality - Percentage Breakdown of Value Sales for Bench-top and Floor-standing for the Years 2012, 2020 & 2027

Table 61: Canada Current & Future Analysis for Blood Cell Analyzer by Application - Clinical Diagnostics, Drug development and Other Applications - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 62: Canada Historic Review for Blood Cell Analyzer by Application - Clinical Diagnostics, Drug development and Other Applications Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 63: Canada 15-Year Perspective for Blood Cell Analyzer by Application - Percentage Breakdown of Value Sales for Clinical Diagnostics, Drug development and Other Applications for the Years 2012, 2020 & 2027

Table 64: Canada Current & Future Analysis for Blood Cell Analyzer by End-Use - Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 65: Canada Historic Review for Blood Cell Analyzer by End-Use - Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 66: Canada 15-Year Perspective for Blood Cell Analyzer by End-Use - Percentage Breakdown of Value Sales for Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes for the Years 2012, 2020 & 2027

JAPAN Table 67: Japan Current & Future Analysis for Blood Cell Analyzer by Product Type - Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 68: Japan Historic Review for Blood Cell Analyzer by Product Type - Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 69: Japan 15-Year Perspective for Blood Cell Analyzer by Product Type - Percentage Breakdown of Value Sales for Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers for the Years 2012, 2020 & 2027

Table 70: Japan Current & Future Analysis for Blood Cell Analyzer by Modality - Bench-top and Floor-standing - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 71: Japan Historic Review for Blood Cell Analyzer by Modality - Bench-top and Floor-standing Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 72: Japan 15-Year Perspective for Blood Cell Analyzer by Modality - Percentage Breakdown of Value Sales for Bench-top and Floor-standing for the Years 2012, 2020 & 2027

Table 73: Japan Current & Future Analysis for Blood Cell Analyzer by Application - Clinical Diagnostics, Drug development and Other Applications - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 74: Japan Historic Review for Blood Cell Analyzer by Application - Clinical Diagnostics, Drug development and Other Applications Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 75: Japan 15-Year Perspective for Blood Cell Analyzer by Application - Percentage Breakdown of Value Sales for Clinical Diagnostics, Drug development and Other Applications for the Years 2012, 2020 & 2027

Table 76: Japan Current & Future Analysis for Blood Cell Analyzer by End-Use - Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 77: Japan Historic Review for Blood Cell Analyzer by End-Use - Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 78: Japan 15-Year Perspective for Blood Cell Analyzer by End-Use - Percentage Breakdown of Value Sales for Hospitals, Diagnostic Centers, Pharmaceutical Companies, Biotechnology Companies, Contract Research Organizations and Academic Research Institutes for the Years 2012, 2020 & 2027

CHINA Table 79: China Current & Future Analysis for Blood Cell Analyzer by Product Type - Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 80: China Historic Review for Blood Cell Analyzer by Product Type - Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 81: China 15-Year Perspective for Blood Cell Analyzer by Product Type - Percentage Breakdown of Value Sales for Semi-automated Biochemistry Analyzers and Fully Automated Biochemistry Analyzers for the Years 2012, 2020 & 2027

Table 82: China Current & Future Analysis for Blood Cell Analyzer by Modality - Bench-top and Floor-standing - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 83: China Historic Review for Blood Cell Analyzer by Modality - Bench-top and Floor-standing Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 84: China 15-Year Perspective for Blood Cell Analyzer by Modality - Percentage Breakdown of Value Sales for Bench-top and Floor-standing for the Years 2012, 2020 & 2027

Table 85: China Current & Future Analysis for Blood Cell Analyzer by Application - Clinical Diagnostics, Drug development and Other Applications - Independent Analysis of Annual Sales in US$ Thousand for the Years 2020 through 2027

Table 86: China Historic Review for Blood Cell Analyzer by Application - Clinical Diagnostics, Drug development and Other Applications Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2012 through 2019

Table 87: China 15-Year Perspective for Blood Cell Analyzer by Application - Percentage Breakdown of Value Sales for Clinical Diagnostics, Drug development and Other Applications for the Years 2012, 2020 & 2027

Link:
Global Blood Cell Analyzer Industry - Yahoo Finance

Biochemistry

Predicting the path of COVID-19 from Wuhan to Buffalo – University at Buffalo Reporter

Jennifer Surtees is a biochemist at UB. For more than two decades, her research has focused on genome stability and how mutations threaten that stability and sometimes lead to cancer.

But when the COVID-19 pandemic caused the temporary shutdown of UB research laboratories last March, Surtees, like many of her colleagues, couldnt help but consider how her expertise might be applied to the novel coronavirus.

When the pandemic started, there was a huge surge of interest research-wise into the pandemic and trying to understand how the virus moved around, says Surtees, associate professor of biochemistry in the Jacobs School of Medicine and Biomedical Sciences at UB and director of UBs Genome, Environment and Microbiome Community of Excellence.

I had watched the early genome sequencing coming out of Seattle and California, and I thought we could totally do this here, she says.

Surtees contacted UBs Office of the Vice President for Research and Economic Development to ask if anyone at UB was doing genome sequencing of the SARS-COV2 virus isolated from Western New York patients. No one was.

So she contacted Teresa Quattrin, senior associate dean for research integration in the Jacobs School and Special Populations Core director in the Clinical and Translational Science Institute; Gale Burstein, Erie County health commissioner and a Jacobs School faculty member; and Carleen Pope, administrative coordinator of the Erie County Public Health Laboratory. All were enthusiastic about Surtees idea.

Its an interesting epidemiological question to get a sense of where the virus is circulating in our community, Surtees says. Are there versions that are more pathogenic or infectious? I wanted to see what we could learn about the accumulation of mutations in Western New York patients.

Surtees explains that rapid genomic sequencing could be used alongside contact tracing to understand transmission of the virus through communities, with the goal of understanding how mutations affect clinical outcomes.

The goal with this project is to get a sense of the evolution of the virus, and where it came from, to find out its genomic epidemiology, to try and understand the biology of this virus, she says.

To do that, she worked with researchers in the sequencing core headed by Norma J. Nowak, executive director of UBs New York State Center of Excellence in Bioinformatics and Life Sciences. Donald Yergeau, associate director of genomic technologies in the Genomics and Bioinformatics Core, established a wet lab pipeline to convert the viral (SARS-CoV-2) RNA genomes derived from patients to DNA through reverse-transcription. The DNA version of the entire genome for each sample was amplified in small fragments and subjected to next-generation sequencing.

Jonathan Bard, a senior bioinformatician, then established a bioinformatics pipeline to compare the sequenced Erie County genomes with the reference genome, the original virus that circulated in Wuhan, China, to identify any changes or mutations in the genome.These genome sequences were uploaded into the nextstrain.org platform to assess phylogeny, a kind of family tree for the viral strains in Erie County, Surtees explains. This predicts the path the virus may have taken to get from Wuhan to Buffalo.

By July, Surtees had received Institutional Review Board approval to study the first batch of 50 deidentified (anonymous) samples isolated from nasal swabs from Western New York patients with COVID-19. They retrieved reliable sequence data from 32 of the samples. Now that that pipeline is in place, Surtees and her team can crank through new samples much more quickly.

Over time, mutations accumulate; thats just life, Surtees says, It happens in all organisms that replicate their genomes. Studying mutations provides us with an evolutionary path. It tells us which genomes are more closely related, the same way we can tell how closely people are related by looking at changes in their DNA sequences. The more mutations that two genomes have in common, the more closely related they are. Genomic sequencing also allows us to see how quickly the virus is mutating.

The question is to find out how mutations may affect infectivity of the virus, to find out which, if any, mutations are functional and which are just being carried along, she continues.

In the first batch of samples from patients who were sick with COVID-19 in early April, the majority, approximately two thirds, of virus samples from Western New Yorkers seemed to be of European origin, primarily Italy, France and Spain. The remaining third appears to have come through China and Singapore.

Surtees says the data from the samples will prove more valuable if it is possible to gather more information, such as gender, age and travel history, from the patients from whom the samples were taken. Since the samples were deidentified, that will require permission from Erie County and from each individual patient, as well as approval by UBs IRB.

Recently, the UB researchers received another 200 samples from the Erie County Public Health Laboratory, which they are running through the pipeline as well.

Surtees has received a small grant from the SUNY Research Foundation to pursue this work, as well as some funding from UBs Genome, Environment and Microbiome Community of Excellence.

She also has begun collaborating on the COVID-19 research with Amy Jacobs, a virologist and research associate professor in the Department of Microbiology and Immunology in the Jacobs School, and with Omer Gokcumen, an evolutionary biologist and associate professor of biological sciences in the College of Arts and Sciences.

They have applied for external funding from the National Institute of Allergy and Infectious Disease of the National Institutes of Health.

Originally posted here:
Predicting the path of COVID-19 from Wuhan to Buffalo - University at Buffalo Reporter