Category Archives: Biochemistry

Biochemistry

Faculty receive grant for heart health research | The Source – Washington University Record

Weikai Li, associate professor of biochemistry and molecular biophysics at the School of Medicine, along with Michael J. Greenberg, assistant professor of biochemistry and molecular biophysics, and Michael L. Gross, professor of chemistry in Arts & Sciences, and of immunology and of medicine at the School of Medicine, received a three-year $750,000 grant from American Heart Association for their research titled Interdisciplinary structural studies of iron homeostasis in cardiovascular health.

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Faculty receive grant for heart health research | The Source - Washington University Record

Biochemistry

Global Automatic Biochemistry Analyzers Market 2020 Growth, Latest Trend Analysis and Forecast 2025 KSU | The Sentinel Newspaper – KSU | The Sentinel…

A recently published report titled Global Automatic Biochemistry Analyzers Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 by MarketQuest.biz broadly analyzes the markets critical aspects such as the vendor landscape, market dynamics, and regional analysis. The report offers end to end industry from the definition, product specifications, and demand till forecast prospects. The report comes out as a compilation of key guidelines for players to secure a position of strength in the global market. The report states global Automatic Biochemistry Analyzers industry developmental factors, historical performance from 2015-2025. The segmental market view by types of products, applications, end-users, and top vendors is given. In addition, the production value growth rate, production growth rate, import and export, and key players of each regional market are provided.

Market Landscape Analysis:

The report provides comprehensive research that focuses on overall consumption structure, development trends, and sales of top countries in the global Automatic Biochemistry Analyzers market. The research study deeply analyzes the global Automatic Biochemistry Analyzers industry landscape and the prospects it is anticipated to create during the forecast period from 2020 to 2025. Key segments are studied about different factors such as consumption, market share, value, growth rate, and production. The report analyzes region-wise revenue and volume for the forecast period of 2015 to 2025.

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NOTE: Our report highlights the major issues and hazards that companies might come across due to the unprecedented outbreak of COVID-19.

Market competition by top manufacturers as follows: Roche, KHB, Abbott, Danaher, Thermo Scientific, Siemens Healthcare, Horiba Medical, Mindray Medical, Hitachi, Abaxis, Sysmex, Randox Laboratories, ELITech, Adaltis, Urit, Senlo, Gaomi Caihong, Dirui, Tecom Science, Sunostik, Rayto

Based on product types, this report focuses on the status and outlook for product types, consumption (sales), market share, and growth rate for types, including: Floor-standing, Bench-top

Based on application, this report focuses on the status and outlook for major applications/end users, consumption (sales), market share, and growth rate for each application, including: , Primary Hospital, Provincial Hospital, Prefectural Hospital

Global Automatic Biochemistry Analyzers market segment by regions, regional analysis covers: North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia and Italy), Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia), South America (Brazil, Argentina), Middle East & Africa (Saudi Arabia, UAE, Egypt and South Africa)

The report delivers marketing type analysis, market supply chain analysis, international trade type analysis, and traders or distributors by region with their contact information. The description of the products comprises the various ex-factors, production & consumption rates, and other factors about the products. The global Automatic Biochemistry Analyzers market report additionally focuses on investigating product capacity, product price, profit streams, supply to demand ratio, production and market growth rate, and a projected growth forecast.

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Moreover, the report minutely studies all such factors which are essential to be known by all major industry players operating into this market or new players planning to enter this global Automatic Biochemistry Analyzers market. The report examines the global Automatic Biochemistry Analyzers market breakdown and anticipates the market volume related to volume and value.

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Global Automatic Biochemistry Analyzers Market 2020 Growth, Latest Trend Analysis and Forecast 2025 KSU | The Sentinel Newspaper - KSU | The Sentinel...

Biochemistry

U of A Researcher Wins Two Scialog Awards – University of Arkansas Newswire

University Relations

Robert Coridan, assistant professor of chemistry and biochemistry in the Fulbright College of Arts and Sciences.

Robert Coridan, assistant professor of chemistry and biochemistry, recently received two individual awards totaling $110,000 at the Scialog: Negative Emissions Science conference, a meeting of Scialog Fellows sponsored by the Research Corporation for Scientific Advancement and the Sloan Foundation. Coridan is a principal investigator on two projects honored by Scialog, "Using Electrochemistry to Improve Selectivity of Plasma-Assisted CO2 Reduction" and "Integrated Low-Temperature Electrified Process for CO2 Direct Air Capture and Transformation to Solid Carbon."

The 2020 Scialog Collaborative Innovation Awards were given to eight collaborative research teams, representing universities across the United States and Canada. Coridan is working with researchers from the University of British Columbia, the University of California, Irvine, the University of Rochester and the University of California, Los Angeles.

A Scialog (a combination of the words "science" and "dialog") is meant to help develop a research community to address scientific challenges of global significance. Scialog Fellows participate in annual meetings over the three-year course of the Scialog to develop collaborations and ideas to tackle these challenges. The Collaborative Innovation Awards initiate research into ideas developed at the meetings. The 2020 Scialog for Negative Emissions Science, held virtually in November, was the first to address solutions for the removal and utilization of greenhouse gases. Other Scialogs have considered topics from a broad range of scientific disciplines, including Advanced Energy Storage, the Chemical Machinery of the Cell, and Signatures of Life in the Universe. Funding for the research awards was provided by the Research Corporation for Science Advancement, the Alfred P. Sloan Foundation and the Thistledown Foundation.

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U of A Researcher Wins Two Scialog Awards - University of Arkansas Newswire

Biochemistry

Scientists discuss inclusion and equity in biomedical research at virtual event – Vanderbilt University News

Biomedical researchers across Vanderbilt University will convene to discuss the history and impact of Black biomedical scientists on Monday, Feb. 15, at noon CT. The virtual discussion, From Inclusion to Equity: The Story of Black Biomedical Scientists, will be moderated by Dr.Andr L. Churchwell, vice chancellor for equity, diversity and inclusion and chief diversity officer.

The event is free and open to the public. Registration is required.

The discussion will cover discoveries and experiences of earlier generations of Black biomedical scientists, the impact of their discoveries, and existing disparities that the academic biomedical community still needs to overcome to reach its full potential.

Panelists areBreann Brown, assistant professor of biochemistry;Ren Robinson, associate professor of chemistry and Dorothy J. Wingfield Phillips Chancellors Faculty Fellow, andSteven Townsend, assistant professor of chemistry and Deans Faculty Fellow in the College of Arts and Science.

Participants will be able to submit questions in advance through the registration page.

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Scientists discuss inclusion and equity in biomedical research at virtual event - Vanderbilt University News

Biochemistry

COVID-19 vaccines mostly effective against new strains, researchers say – The Stanford Daily

Following the global and local emergence of COVID-19 variants, Stanford researchers predict that the Pfizer and Moderna vaccines will continue to be mostly effective in the near future, though each of the new strains responds differently to the current vaccines.

Multiple variants have been identified to date, but the most concerning ones are the B.1.1.7 strain discovered in the United Kingdom, B.1.351 in South Africa and P.1 in Brazil all of which have already reached the United States. Recently, the new L452R strain identified in Denmark caused outbreaks in Santa Clara County.

While the B.1.1.7 variant is fully susceptible to vaccine-induced immunity, B.1.351 is less susceptible but still within the range where we expect some protection, associate medicine professor Catherine Blish wrote in an email to The Daily.

According to infectious disease clinical professor Stanley Deresinski, the Moderna vaccine has a six- to nine-fold reduced potency on the B.1.351 variant but no loss in potency forB.1.1.7. The vaccine efficacy rates for the other variants have yet to be reported.

However, researchers said that even if new mutations do render the current vaccines ineffective, they can easily be updated to block against new strains. Moderna has already initiated its Phase I testing for a vaccine booster dose against B.1.351, according to Blish and Deresinski.

One of the values of mRNA vaccines is that new ones can be produced in the laboratory within weeks, Deresinski wrote in a statement to The Daily. Jennifer Haller received the first dose of the Moderna vaccine 66 days after scientists in the U.S. were able to view the published genetic code of SARS-CoV-2.

Infectious disease clinical professor Jake Scott referred to the mRNA vaccines as nimble and strong to begin with. This offers some wiggle room even if the vaccines were six-fold less active, they would still potentially be effective, he said.

Next in line for approval are the Johnson & Johnson and Novavax vaccines, but recent testing indicated that they experience reduced efficacy against the B.1.351 strain from South Africa, according to sixth-year chemistry Ph.D. student Payton Weidenbacher. Weidenbacher is currently working in biochemistry professor Peter Kims lab to develop a nanoparticle vaccine that can be kept at less extreme temperatures.

While the Johnson & Johnson vaccine demonstrated a 72% efficacy rate in the U.S. but only a 57% rate in South Africa, it still offers complete protection against severe disease and death for those who are infected, Weidenbacher said.

Part of Johnson & Johnsons Phase 3 trial was conducted at Stanford, and the company sent their vaccine in to be considered for emergency use authorization last week.

Shifting the direction of vaccine research

The mutating SARS-CoV-2 virus is not an unexpected development but rather a completely normal progression of the disease, Blish wrote. Many vaccine developers have anticipated the emergence of variants and have already been tackling it in their research, she added.

Associate biochemistry professor Rhiju Das leads the OpenVaccine challenge at Stanford, working to design a highly stabilized mRNA vaccine that could allow the deployment of mRNA vaccines without freezing.

Das said that he and his lab have now started addressing the new variants, figuring out how to rapidly redesign the mRNA sequences in their vaccines to code for the emerging strains.

The real worry, though, is that more variants will arise that will completely escape the vaccines, Das said. Once they see the medicines were deploying, the viruses will be under pressure to evolve resistance.

Meanwhile, in the Kim Lab, Weidenbacher and his colleagues have started investigating the major new strains for their nanoparticle vaccine.

The big question that were grappling with is: what is the best variant to immunize? Weidenbacher said.

To answer this question, the lab is pinpointing the mutations that the variants have in common, which are likely the ones that have an evolutionary advantage and will continue to be found in future strains.

If three independent occurrences around the world have all elicited the same sets of mutations, it seems like those mutations are relevant to include in a new vaccine, Weidenbacher explained.

Looking forward, Weidenbacher said that people dont know if this virus is going to keep on mutating like the flu, or if it will hit some sort of plateau and converge into a single strain.

High mutational frequency is the reason why we need new flu vaccines every year and have not yet developed a vaccine for human immunodeficiency virus (HIV), Blish said. However, she believes its unlikely that we will require yearly vaccines because coronaviruses simply dont mutate as quickly as influenza.

According to Deresinski, the typical SARS-CoV-2 virus mutates at a rate about half that of influenza and a quarter that of HIV.

The news about these new variants coincided with the rollout of these incredibly effective vaccines, so its basically a kick in the butt to really do everything we can to vaccinate as many people as possible, Scott said.

Contact Athena Xue at axue8 at stanford.edu.

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COVID-19 vaccines mostly effective against new strains, researchers say - The Stanford Daily

Biochemistry

Named positions celebrate the work of Rochester’s faculty – University of Rochester

February 8, 2021

The University of Rochesters Board of Trustees has appointed faculty members to named professorships. An honor designed to recognize the national stature of a professors work, the named positions are part of a long-standing tradition to celebrate the work of Rochesters faculty as researchers, scholars, and teachers.

Recent appointments include the following:

Andrew Ainslie, former dean of the Simon Business School, has been appointed as the Benjamin Forman Professor in Marketing. Ainslies primary research interest is economic and statistical models of heterogeneity in consumer behavior and segmentation.

The professorship was established by an anonymous donor.

Hani Awad, a professor of orthopaedics in the Center for Musculoskeletal Research, has been jointly appointed as the Donald and Mary Clark Distinguished Professor in Orthopaedics. The research of Awad, a member of the School of Medicine and Dentistry faculty since 2004, focuses on musculoskeletal tissue engineering.

The position is named for the late Donald Clark and his late wife Mary Clark, who were longtime friends and supporters of the University.

Laura Calvi, a professor of medicine, has been appointed as the SKAWA Foundation Professor in Endocrinology and Metabolism. Calvi retains her joint appointments as professor of neurosurgery, of oncology, of pathology and laboratory medicine, and of pharmacology and physiology. Her lab examines the cellular and molecular mechanisms of microenvironmental regulation of hematopoietic stem cells in the bone marrow.

Established by the Board of Trustees in 2020, the SKAWA Foundation Professorship in Endocrinology and Metabolism is intended to support an endowed professorship in endocrinology and metabolism in the School of Medicine and Dentistry.

Christopher Cook, a professor of orthopaedics, has been jointly appointed as the Dr. C. McCollister Evarts Professor in Orthopaedics. Cook, chief of the Orthopaedic Pediatric Division, specializes in pediatric orthopaedics, hip dysplasia in children and young adults, and complex hips.

The position was established by Mac Evarts 57M (MD), 64M (Res), a former Medical Center CEO.

Kathi Heffner, an associate professor of nursing, of medicine, and of psychiatry, has been jointly appointed as the Marie C. Wilson and Joseph C. Wilson Professor in the School of Nursing. Heffners research centers on how social, psychological, and behavioral factors promote or impair physiological stress adaptation and immune/inflammatory regulation.

The Marie Curran Wilson and Joseph Chamberlain Wilson Professorship Fund has supported professorships that have historically included disciplines ranging from biology, economics, history, political science, medicine, and optical physics. Heffner and Feng (Vankee) Lin, included below, are the first Wilson Professors in the School of Nursing. The fund, directed by the Universitys Board of Trustees, is named for Joe Wilson 31, founder of Xerox, and his wife, Marie (Peggy) Wilson, a former member of the board.

Benzi Kluger, a professor of neurology, has been jointly appointed as the Julius, Helen, and Robert Fine Distinguished Professor in Neurology. Kluger retains his joint appointments as professor of medicine and as professor in the Center for Health and Technology. Klugers research interests focus on how palliative care approaches can improve the lives of patients and families affected by neurologic illnesses. He is founding director of the of the Medical Centers Palliative Care Research Center and Neuropalliative Care Division.

The professorship, established in 2019 by the Board of Trustees, was created at the suggestion of Paul Fine 57, 61M (MD), 66M (Res) by his nephew, Robert Fine, in his and his parents names.

Feng (Vankee) Lin, an associate professor of nursing, has been appointed as Marie C. Wilson and Joseph C. Wilson Professor in the School of Nursing. She retains her joint appointments as an assistant professor of neuroscience, of brain and cognitive sciences, and of psychiatry. Lin is a nationally recognized leader in research on cognitive aging and dementia among older adults.

The Marie Curran Wilson and Joseph Chamberlain Wilson Professorship Fund has supported professorships that have historically included disciplines ranging from biology, economics, history, political science, medicine, and optical physics. The fund, directed by the Universitys Board of Trustees, is named for Joe Wilson 31, founder of Xerox, and his wife, Marie (Peggy) Wilson, a former member of the board.

David Mathews 94, 02 (PhD), 03M (MD), a professor of biochemistry and biophysics, has been jointly appointed as the Lynne E. Maquat Distinguished Professor. The Mathews Lab is interested in predicting RNA structure and developing computational tools for targeting RNA with pharmaceuticals and for using RNA as a pharmaceutical.

This new professorship, established in 2020, was made possible by the support of anonymous donors in honor of Lynne Maquat, the J. Lowell Orbison Professor of Biochemistry & Biophysics in the School of Medicine and Dentistry.

Honey Meconi, a professor of music, has been jointly appointed as the inauguralArthur Satz Professor for the Department of Music. Meconi, who is also a professor of musicology at the Eastman School of Music, is an expert on Renaissance music as well as the music of Hildegard of Bingen.

The professorship is named for the late Arthur Satz 51a music major and the late president emeritus at the New York School of Interior Design (NYSID). The Department of Music in the School of Arts & Sciences is also named for Satz.

Huaxia Rui, an associate professor of business administration at the Simon Business School, has been appointed as Xerox Professor of Computers and Information Systems. Ruis research interests include social media, health IT, and optimal contract design.

The Xerox Foundation supports endowed professorships in manufacturing management and information systems management for both senior and junior faculty at the Simon Business School.

Giovanni Schifitto, a professor of neurology, has been jointly appointed as the Esther Aresty Granite Professor in Neurology. Schifitto retains his joint appointment as a professor of imaging sciences. Schifittos major research interests are in the development and implementation of novel neuroimaging biomarkers applied in the investigation and treatment of neuroinflammatory, neurodegenerative, and cerebrovascular disorders.

Established in 2018, this professorship was made possible with a gift from Joseph Aresty, and the Catherine and Joseph Aresty Foundation, in honor of Joseph Arestys sister Esther.

Tags: Andrew Ainslie, Arts and Sciences, Benzi Kluger, Christopher Cook, David Mathews, Eastman School of Music, Feng (Vankee) Lin, Giovanni Schifitto, Hani Awad, Honey Meconi, Huaxia Rui, Kathi Heffner, Laura Calvi, medical center, School of Medicine and Dentistry, School of Nursing, Simon Business School

Category: University News

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Named positions celebrate the work of Rochester's faculty - University of Rochester

Biochemistry

Biochemistry, Doppler echocardiography, and electrocardiography evaluation in captive owl monkeys (Aotus sp). – Physician’s Weekly

The cardiovascular system of owl monkeys has been studied due to frequent postmortem findings of heart disease in asymptomatic animals. The silent aspect and the difficulty of early diagnosis intensify the importance of studying the cardiovascular system in this species.Echocardiogram evaluation was carried out on 60 animals, grouped into suspect or non-suspect of having heart diseases, and evaluated through electrocardiogram, hematology, and biochemical tests.Doppler echocardiography indicated two animals with suspicion of left ventricular hypertrophy and eight with dilated cardiomyopathy. Suspect animals had higher cardiac measurements and reduced shortening fraction. Troponin I was detectable in two animals (0.128ng/mL and 0.584ng/mL), and serum albumin concentration was significantly higher in non-suspect animals (P<.05).The importance of echocardiographic measurements of IVSd, IVSs, LVIDd, LVIDs, LVPWd, LVPWs, LA, EF, and FS in the cardiac evaluation of captive owl monkeys was evidenced.

PubMed

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Biochemistry, Doppler echocardiography, and electrocardiography evaluation in captive owl monkeys (Aotus sp). - Physician's Weekly

Biochemistry

Student Scientist Searches for Therapeutics to Treat West Nile Virus | CSUF News – CSUF News

Biochemistry major Shaina Nguyen works in the lab on her West Nile virus research project.

With no treatment or cure for West Nile virus spread through the bite of an infected mosquito Cal State Fullerton undergraduate researcher Shaina Nguyen is working on creating new therapeutics to treat people infected with the disease.

Hopefully, our research could provide possible drug therapeutics to stop West Nile virus, Nguyen said.

Since her freshman year, Nguyen, a biochemistry major who is graduating in May, has worked in the lab of Nicholas T. Salzameda, associate professor of chemistry and biochemistry. The researchers are seeking treatments since there is no vaccine or medications available for the mosquito-borne disease.

In the ongoing study, the faculty-student research team is studying a viral protein for the West Nile virus, known as the NS2B-NS3 protease, which is responsible for producing viral particles for replication and is a promising therapeutic target in stopping infection, Nguyen said.

The lab also is experimenting with Zafirlukast, a currently available anti-asthmatic drug.

Given the structure of Zafirlukast, we want to make modifications to this drug to see if it could further improve the inhibition against the West Nile virus NS2B-NS3 protease, she said.

According to the Centers for Disease Control and Prevention, during mosquito season, which starts in the summer and continues through fall, about 1 in 5 people who are infected with West Nile virus develop a fever and other symptoms. About 1 out of 150 infected people get a severe condition, including neurological symptoms, such as meningitis and encephalitis, or sometimes, fatal illnesses.

Glenn Nagel Undergraduate Student Research Award

For her outstanding research and presentation, Nguyen received the Glenn Nagel Undergraduate Student Research Award at the recent 33rd annual California State University Biotechnology Symposium. The award is named in honor of Nagel, a former biochemistry professor at Cal State Fullerton who became a dean at Cal State Long Beach. The Nagel Award fosters excellence in undergraduate student research.

The virtual symposium, presented by the California State University Program for Education and Research in Biotechnology, featured 36 student nominees and finalists from 13 campuses who competed for systemwide undergraduate and graduate research awards.

Its humbling to receive this award. Dr. Salzameda has pushed me and guided me to realize my dreams for graduate school, said Nguyen, an award-winning scholar who has presented her research at regional and national conferences.

Nguyen is a scholar in the universitys Maximizing Access to Research Careers (MARC) program, which prepares students for graduate school and careers in biomedical research, a Presidents Scholar and University Honors Program student.

Her research adviser relayed that Nguyen, who plans to pursue an M.D.-Ph.D. program to become a physician-scientist in a clinical setting, is a top student scholar.

Shaina has always found ways to amaze me, whether earning As in all her courses or making a new molecule that others could not make, Salzameda said. The M.D.-Ph.D. programs are reserved for the very best students. Shaina will succeed and put her talents to improving the health care of people through biomedical research.

Nguyens parents, who were teenagers, and grandparents fled Vietnam in the late 1970s. Her close family ties reinforce the importance of holding on to her Vietnamese culture and her academic pursuits and career goals.

She has maintained a 4.0 GPA, despite the personal loss of both her grandmothers while in college. Nguyen pressed on by spending long hours in the lab several days a week to work on her research project, earning good grades and staying on track to graduate in four years.

My grandmothers wouldnt have wanted me to stop, Nguyen said. This research project has required a lot of hard work, with bumps along the way, but it has paid off.

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Student Scientist Searches for Therapeutics to Treat West Nile Virus | CSUF News - CSUF News

Biochemistry

Bio-Based Itaconic Acid Market 2021 | Key Findings, Trends, Market Share, and Growth Forecast | Thermo Fisher Scientific., Itaconix Corporation,…

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The major players covered in the bio-based itaconic acid market report are Thermo Fisher Scientific., Itaconix Corporation, Qingdao Kehai Biochemistry Co., LTD., AEKYUNG PETROCHEMICAL Co., Ltd, Zhejiang Guoguang Biochemistry Co.,Ltd., Spectrum Ultimate Chem India Pvt. Ltd, Alpha Chemika, Haihang Industry Co., Ltd, Ronas Chemicals Ind. Co., Ltd., Hefei TNJ Chemical Industry Co.,Ltd., Alfa Aesar, Merck KGaA, Choice Organochem Llp., FUSO CHEMICAL CO., LTD., Henan Haofei Chemical Co.,Ltd., Chemical Manufacturing Corp and FUJIFILM Wako Pure Chemical Corporation, among other domestic and global players. Market share data is available for global, North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

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Chapter 1: Bio-Based Itaconic Acid Introduction and Market Overview1.1 Objectives of the Study1.2 Overview ofBio-Based Itaconic Acid1.3 Scope of The Study1.3.1 Key Market Segments1.3.2 Players Covered1.3.3 COVID-19s impact on the Bio-Based Itaconic Acid industry1.4 Methodology of The Study1.5 Research Data Source

Chapter 2: Market Dynamics2.1 DROC2.1.1 Drivers2.1.2 Restraints2.1.3 Opportunities2.1.4 Challenges2.2 PEST Analysis2.2.1 Political2.2.2 Economic2.2.3 Social2.2.4 Technological2.3 Market Impacting Trends2.4 Porters 5-force Analysis

Chapter 3: Segmentation & Statistics3.1 Segmentation Overview3.2 Demand Forecast & Market SizingContinued..

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Bio-Based Itaconic Acid Market 2021 | Key Findings, Trends, Market Share, and Growth Forecast | Thermo Fisher Scientific., Itaconix Corporation,...

Biochemistry

Fully Auto Biochemistry Analyzer Market 2021-2027 Global Industry to Revenue Growth in the Coming Years NeighborWebSJ – NeighborWebSJ

Global Fully Auto Biochemistry Analyzer Market 2021-27 Abbott, Hitachi, Mindray Medical, Thermo Scientific

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RocheDanaherSiemens HealthcareAbbottHitachiMindray MedicalThermo ScientificKHBAbaxisHoriba MedicalELITechGaomi CaihongSunostikSenloSysmexUritTecom ScienceRandox LaboratoriesDiruiAdaltisRayto

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Floor-standingBench-top

Major applications included in this report are:

HospitalResearchOthers

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Fully Auto Biochemistry Analyzer Market 2021-2027 Global Industry to Revenue Growth in the Coming Years NeighborWebSJ - NeighborWebSJ