Category Archives: Biochemistry

Students, Faculty Respond to Discrimination Allegations within Oberlin STEM – The Oberlin Review

Two weeks ago, the Biochemistry Department hosted a listening session to allow students to share concerns about diversity and inclusion within the department. The meeting came after an opinions piece published in the Review elicited a strong reaction from students, faculty, and alumni.

In the original article, College fourth-year Ritesh Isuri discussed their experiences with racial and gender-based discrimination in the Biochemistry and Physics departments. According to Isuri, they have received over 300 messages from students and alumni who resonated with their story.

I think one thing that was really surprising to me is the sheer amount of emails, Isuri said. Ive got messages and texts as responses from students. [Students and alumni] have been telling me Im not the only one; theyre also having issues like that. And they did share a few personal stories with me. Its just insane to think 300 students have reached out about these things and that so many of them are alumni. So how long has this been going on?

Howard Hughes Medical Institute STEM Fellow Marcus Hill, OC 19, held the listening session to learn more about students concerns. HHMI is a grant program at Oberlin College committed to addressing inequity in the sciences.

There were stories of students who felt like they had experienced a microaggression at best or something more severe at worst wanting to see change, Hill said. I think so much of that problem exists because of the boundaries and the communication that we have.

After the listening session, Hill developed ideas that he could bring to faculty to enhance discussions around equity in the department. He plans to meet with the faculty to share student concerns and encourage faculty to incorporate discussions of inclusivity inside the classroom.

In addition to eliciting responses from students, Isuris op-ed also garnered the attention of faculty. Some were surprised when they read the article because they were unaware of the discriminatory treatment within Oberlin academic departments.

Im really close to my professors, which is why they were shocked when I told them about these things, Isuri said. They were like, Oh, Im close to you. I did not know you had to go through all these things at Oberlin. It is insane, but I am not alone, this happens to everybody to everybody who looks like me. Although I was disappointed with the initial surprise, I just think they needed the time to process it. And now what Im seeing is they are willing to take actions. Im happy about that.

After digesting this information, faculty have committed to making changes to ensure that the Biochemistry department is more inclusive including changes that specifically respond to the concerns voiced by international students.

We never want to see students in bad situations, said Associate Professor and Chair of Chemistry and Biochemistry and HHMI Program Director Jason Belitsky. I think everyone on the faculty responded in that way; we wanted to do whatever we can to make the department as welcoming and inclusive as possible and avoid any negative situations that have happened in the past or are still happening.

The Biochemistry department has promised to expand research opportunities, review departmental awards, and bolster general support for international students. The department is also planning an alumni listening session with the hope that former students will feel more comfortable speaking to faculty about problems in the department.

Other STEM departments are also examining their practices. This past year, three departments have established Departmental Action and Reflection Teams, an HHMI process aimed at improving inclusivity in STEM. Next year, another four departments will assemble DARTs, including Biochemistry.

Hill hopes that DART will give departments more tools to have these kinds of conversations next year. Departments that went through the DART process this year were able to enact changes to improve inclusivity for example, Geology strengthened the student representatives role in the department and instituted a more democratic process for their election.

Isuris op-ed resonated with Yasmine Ramachandra, OC 19, who hopes that the article will continue to spark dialogue.

It reflected a lot of my experiences and also just affirms how I felt while I was at Oberlin, Ramachandra said. Previously, when I had talked about things, it was always within the department, and it was never some external force putting pressure on the department, which is why I really appreciated what [Isuri] wrote.

Going forward, Ramachandra hopes to see continued changes. She believes that STEM departments should focus on recruiting more students of color, specifically Black students, and create a more permanent position for diversity and inclusion than the current HHMI fellowship.

Additionally, Ramachandra believes that there is a need for more avenues to hold students and professors accountable for their actions. While the Office of Equity, Diversity, and Inclusion exists to help students report instances of racism, not all students are aware of this resource.

[In the Geology department,] I know there are conversations about making more obvious ways of reporting any discomfort going on in the department, whether its with a particular professor or student, or if theres unsafe lab practices that you want to address, Hill said. Obviously the College promotes going to Title IX, if there are those sorts of things. But besides that, I dont know that there is any sort of process laid out of how to bring these up in a way that that feels appropriate.

For students, the patchwork set of processes for getting help might include talking to Hill directly, reaching out to a trusted faculty member, or talking to other students. Faculty often hear about incidents secondhand or thirdhand.

Ive opened up chair office hours, Belitsky said. Thats one avenue, but I think thats definitely something for us to work on is to have better routes of communication for different concerns.

Reporting problems to a department chair can often be difficult because of a chairs close relationship with their faculty members, as well as the lack of protocol around accountability measures. Additionally, some students may hesitate to speak to department chairs because they are concerned about retaliation. Ramachandra spoke to a negative experience that she had in conversation with a professor.

There was one point where I complained multiple times about a professor who is no longer at Oberlin, Ramachandra said. I remember trying to go to office hours to get feedback on a test and [earn] points back when my answer was the exact same as my friends answers who got full credit, and I didnt get any credit. That professor was so disrespectful to me and alluded to things that I had brought up when meeting with the department head at the time. So I know that this particular professor had heard what I said, and I felt like it was being thrown back in my face.

For Ramachandra, this conversation was exemplary of her experience trying to confront issues in Oberlins STEM departments.

It felt like they were saying, Im not going to help you because you complained about me, she said. But the thing is that when I bring up criticism, its not because I want someone fired; its because I want to see action being taken, whether its a conversation or disciplinary action.

Concerns about retaliation are especially salient for students in STEM departments who need strong grades and letters of recommendation to apply for graduate school. For international students, grad school acceptances or job offers are often essential to ensure their immigration status allows them to stay in the U.S. after graduation.

I also wish [departments] had some sort of process that outlines the steps [professors] need to take when they treat their students differently and these [steps] are like disciplinary actions, Ramachandra said. I just dont see a ton of policy [for] accountability. I see a start of conversations about accountability, but theres nothing really integrated into the foundation of the department yet.

If a student has experienced discrimination they are encouraged to report their experience to the College using this link. Students are also invited to share their experiences with the Review at [emailprotected].

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Students, Faculty Respond to Discrimination Allegations within Oberlin STEM - The Oberlin Review

Global Electrolyte and Biochemistry Analyzers Market 2020 Key Players Analysis, Competitive Landscape and Forecast to 2025 KSU | The Sentinel…

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Global Electrolyte and Biochemistry Analyzers Market 2020 Key Players Analysis, Competitive Landscape and Forecast to 2025 KSU | The Sentinel...

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Segment by TypeElectrolyte AnalyzersBiochemistry Analyzers

Segment by ApplicationHospitalClinicLabsOthers

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UVM gets $9 million to explore epigenetics of breast cancer – Vermont Biz

Larner College of Medicine faculty Gary and Janet Stein are principal investigators on a new $9 million grant from the National Cancer Institute to explore the epigenetics of breast cancer with the goal of finding new drug targets. (Photos: Sally McCay, Larner College of Medicine)

Vermont Business Magazine A team of University of Vermont scientists and physician investigators at the UVM Cancer Center and the Northern New England Clinical and Translational Research Network has been awarded a $9 million, five-year grant from the National Cancer Institute (NCI) to investigate the underlying causes of breast cancer with the goal of identifying new cellular-level targets that could be treated with drugs to prevent the disease or halt its progression.

The principal investigators for the project are Gary Stein, PhD, Perelman Professor and chair of the UVM Larner College of Medicine Department of Biochemistry and professor of surgery, and Janet Stein, PhD, a professor of biochemistry at the Larner College of Medicine. They lead a large, collaborative team representing scientific expertise across three colleges at the University of Vermont.

The competitive grantabout 5 percent of similar NCI grant proposals are fundedcame to UVM, in part, because of the research teams track record.

The NCI is investing in research groups that have made major, proven contributions, said Gary Stein. There is a high expectation that the progress wont be incremental but will represent a paradigm shift.

Stein and his collaborators have published their earlier findings on the underlying mechanisms of breast cancer in publications ranging from Nature to Cancer Research. The new work will build on the previous research contributions to expand both general understanding of breast cancer dynamics and how that molecular-level knowledge could reveal new potential drug targets leading to novel, more effective treatments.

The research will focus on three interrelated projects to determine what goes awry when cell division in healthy breast tissue becomes defective and produces cancer cells. Its focus will be on epigenetics, the instructions that proteins and nucleic acids within a cells nucleus give to its genetic codeits DNAthat tell genes to turn on or off. When a cell reproduces, these epigenetic instructions are passed on to newly formed cells, along with the parental cell DNA, its genetic blueprint. If the epigenetic instructions dont function precisely, cells can become cancerous.

The goal is understanding cancer-compromised epigenetic control of genes in breast tumors, Janet Stein said.

The first project will examine in detail how instructions for the epigenetic regulation of geneswhether they are turned on or off, or poised to turn onare passed on from a parent cell to its two offspring cells accurately, so there are no defects in the control of its specialized function or its ability to go through cell division in a normal way, Janet Stein said.Were trying to understand, precisely, what are the components, what are the epigenetic factors that remain with the gene during cell division, in order to ensure that you are not going to compromise normal function in the progeny cells.

The second project focuses on the proteins, called histones, that organize the two-and-a-half yards of DNA within a cells nucleus into intricate folds inside a chromosome. If these proteins bind a section of the folded DNA tightly, genes wont be expressed; if the bond is loose, the genes will be expressed or poised to express. In cancer cells, the ability to modify these proteins is undermined. The project will seek both to chart how the DNA organizing process works and identify drug targets that will restore function of cancer-compromised proteins.

In the third project, researchers will examine the functioning of a type of long non-coding RNA found in a cells nucleus that the research team discovered in an earlier project. It is present only when cells divide, the team found, and is associated with breast cancer, especially in its most aggressive forms, and is not responsive to conventional cancer treatments. The earlier work showed that, if the activity of this particular type of RNA is blocked, the cancer cell is unable to reproduce and dies. It is a prime drug target, Gary Stein said.

Technology and Team-based Approach Helped Win the Day

UVM has two other capabilities that helped the Cancer Center team win the grantaccess to advanced technology and the strength of its collaborative scientific team. The Larner College of Medicines advanced genome sequencing, microscopy and bioinformatics core facilities allow researchers to peer into cells and chromosomes and view genes and proteins visually in three dimensions.

We have a saying: Seeing is believing, Gary Stein said. The work would be impossible without this highly advanced instrumentation and the world-class expertise behind that technology, which allow us to identify and visualize modified genes and gene expression in cancer cells. It was definitely a credential that the NCI looked favorably on.

In addition, the NCI places priority on what it calls collaborative team science, an interdisciplinary research approach that is the fabric of the UVM Cancer Center.

Collaboration is the guiding principle for the UVM Cancer Center, Gary Stein said.We engage the complementary perspectives, expertise and experience of clinicians, oncologists, molecular biologists, biochemists, bioinformaticists, pathologists and others. UVMs breadth and culture incentivize partnerships that synergize to accelerate the translation of laboratory discovery to advances in cancer prevention, early detection, treatment and survivorship, he said.

Members of the research team come from the University of Vermonts Larner College of Medicine, College of Nursing and Health Sciences, and College of Engineering and Mathematical Sciences and cover both basic science and clinical departments.Members of the team, in addition to Gary and Janet Stein, are Mark Evans, Seth Frietze, Karen Glass, Jonathan Gordon, Peter Kaufman, Jane Lian, Jason Stumpff, Coralee Tye, Pamela Vacek, Jos Van der Velden, Donald Weaver and Marie Wood. Andrew Fritz and Kirsten Tracy are NCI postdoctoral fellows participating in the project.

Source: University of Vermont 4.6.2021

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UVM gets $9 million to explore epigenetics of breast cancer - Vermont Biz

Burlington High graduate finds the right fit with Westminster volleyball – Burlington Hawk Eye

Edward Everett Hale penned the novel, 'A Man Without A Country' in 1863, a story aboutAmerican Army lieutenant Philip Nolan, who renounces his country during a trial for treason, and is consequently sentenced to spend the rest of his days at sea.

In the summer of 2020, Gretchen Durbala was a college athletewithout a school.

Durbala, a graduate of Burlington High School, was getting ready for her senior year at MacMurray College in Jacksonville, Illinois. But MacMurray shuttered its doors, its financialstruggles pushed over the edge by the COVID-19 pandemic.

Just 18 months before she was supposed to walk across the stage to get her degree in biochemistry and just weeks before the start of her senior season of volleyball was supposed to begin, Durbala was scrambling to find a school.

Up steppedNatalia Koryzna, head volleyball coach at Westminster College in Fulton, Missouri. Koryzna had seen Durbala play, since the schools were in the St. Louis Intercollegiate Athletic Conference together.

One thing led to another, and suddenly Westminster had a setter and Durbala had a new home.

It has been a perfect fit for all involved.

"MacMurray College announced they were not opening up in the fall, they were shutting down. I was a littlebit in shock. I really didn't know what to think," Durbala said. "In a matter of hours I was getting calls asking me ifI wanted to play volleyball for my senior season. (Koryzna) called and asked me if I was interested in playing for her.

"They already knew me and I knew how they played. My parents and I went down on a visit. I had never been there or met any of the girls. But I knew it was the perfect fit for me."

Durbala was actually in the middle of a class when the news broke that MacMurray College was closing its doors forever.

"The kids and teachers didn't know what to do," Durbala said. "The teacher said, 'Okay, I guess we are done with class for the day.'"

Durbala helped the Blue Jays to a 13-3 season, including 11-2 in the SLIAC, where they shared the regular-season title with Greenville. Westminster advanced to the conference championship match this spring before falling to Greenville, which handed the Blue Jays two of their three losses this season.

Durbala made a smoothtransition, helped when the pandemic pushed the start of the season from fall to spring. She got her 1,000th career assist this season and finished 38th in NCAA Division III, averaging 9.19 assists per set. The 5-foot-10 Durbala garnered second team All-SLIAC honors, whileKoryzna was named co-Coach of the Year in the SLIAC.

"It was a pretty smooth transition. It helped that the season was pushed back to the spring, especially with 10 incoming freshman and myself. We had a lot of new people on the team and we all had to get to know each other," Durbala said. "I had a couple extra months to get to know everyone and know how and where they want the ball set. We got it all figured out pretty quickly and had a really good season."

Because of the COVID-19 pandemic, Durbala was granted an extra year of eligibility. She will return to Westminster College for the fall semester and complete work on her biochemistry major. From there, it's probably off to physician's assistant school.

Now, Durbala hopes Westminster will have a volleyball season in the fall.

"I have to go back anyway, so hopefully they get to play in the fall," Durbala said. "It would be really nice to get to play one more year of volleyball."

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Burlington High graduate finds the right fit with Westminster volleyball - Burlington Hawk Eye

Tetrachloropyridine Regional Analysis, Key Players and Forecasts till 2026 Chongqing Huage Biochemistry, Nanjing Red Sun, Jubilant Life Sciences,…

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Penrose TherapeuTx Expands Scientific Advisory Board with Three World-Renowned Oncology Researchers – PharmiWeb.com

Drs. Mircea Ivan, David Rubin and Patrick Farmer join Penroses growing board of experts in latest round of scientific appointees

ANN ARBOR, Mich. & CHICAGO--(BUSINESS WIRE)--Penrose TherapeuTx, a pharmaceutical company focused on developing innovative small-molecule therapies for the treatment of advanced cancers, has welcomed three new leading oncology researchers to serve on the companys advisory board. Penroses deep bench of scientific advisors will now also include Mircea Ivan, M.D., Ph.D., a microbiologist and immunologist whose research contributed to the 2019 Nobel Prize in Medicine or Physiology for the discovery of how cells sense and adapt to oxygen availability, David Rubin, M.D., a gastroenterologist with expertise in high-risk cancer syndromes, inflammatory bowel diseases and clinical trial design, and Patrick Farmer, M.D., a chemical and biochemical expert whose research includes metal-based therapies for melanoma.

Drs. Ivan, Rubin and Farmer all bring world-class experience across the many interconnected fields of oncology research, said Mark de Souza, CEO of Penrose TherapeuTx. With unique backgrounds in microbiology, gastroenterology and chemistry, we believe their expertise will propel and expedite our novel mitochondrial research platform through the next stages of development.

Dr. Mircea Ivan is an Associate Professor of Medicine at the University of Indiana School of Medicine and a leading researcher in hypoxia, having pioneered the study of noncoding RNAs regulated by oxygen deprivation. He is also focused on combinatorial therapeutic approaches in oncology and tumor metabolism. Dr. Ivans research with Dr. William Kaelin (Dana-Farber Cancer Institute) showing how normal oxygen levels control rapid HIF-1 degradation with the help of oxygen-sensitive enzymes contributed to the 2019 Nobel Prize in Medicine or Physiology.

Dr. David Rubin is an international thought leader in the field of gastroenterology and the Joseph B. Kirsner Professor Chair, Chief of the Section of Gastroenterology, Hepatology and Nutrition, and the Co-Director of the Digestive Diseases Center at the University of Chicago Medicine. His 30 plus years of clinical expertise includes high-risk cancer syndromes and inflammatory bowel diseases (Crohns disease and ulcerative colitis) with particular interest in the prevention of cancer associated with these gastrointestinal (GI) diseases, as well as better screening tools for colorectal cancer.

Dr. Patrick Farmer is a Professor and Chair of the Department of Chemistry and Biochemistry at Baylor University who has extensively researched melanoma and brings over 30 years of chemical and biochemical expertise to the scientific advisory board. His research groups early study of the pigment melanin as a means of targeting melanoma led to chelator-based therapies that are currently in clinical trial for several types of cancer.

Drs. Ivan, Rubin and Farmer join current board members Dr. Navdeep Chandel, a Professor of Medicine, Biochemistry and Molecular Genetics at Northwestern University Feinberg School of Medicine with over 25 years of experience focused on understanding mitochondria as signaling organelles, Dr. Bhardwaj Desai, Chief Development Officer at Penrose TherapeuTx and a leader in oncology clinical drug development across all classes of medication and phases of development, and Dr. James Stankiewicz, a Professor of Otolaryngology at the Loyola University Medical Center in Chicago for over four decades.

About Penrose TherapeuTx

Penrose TherapeuTx is a U.S.-based pharmaceutical company focused on developing innovative small-molecule therapies for the treatment of advanced cancers. Penrose has pioneered the development of a novel Mitochondrial Modifying Agent (MMA) therapeutic platform designed to generate therapies for difficult to treat cancers through a unique cooperative mechanism of action. Our approach has potential broad applicability across both hematologic and solid tumors. Learn more at https://penrosetherapeutx.com.

Chad HyettMCS Healthcare917-204-7917chadh@mcspr.com

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Penrose TherapeuTx Expands Scientific Advisory Board with Three World-Renowned Oncology Researchers - PharmiWeb.com

Surprising lung reaction may explain why COVID is hard to treat – Futurity: Research News

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New insights into the immune response to SARS-CoV-2 infections could bring better treatments for COVID-19 cases.

Researchers unexpectedly found that the virus triggers a biochemical pathway, known as the immune complement system, in lung cells. That might explain why the disease is so difficult to treat.

The research appears in the journal Science Immunology.

The researchers propose that the pairing of antiviral drugs with drugs that inhibit this process may be more effective. Using an in vitro model using human lung cells, they found that the antiviral drug Remdesivir, in combination with the drug Ruxolitinib, inhibited this complement response.

This is despite recent evidence that trials of using Ruxolitinib alone to treat COVID-19 have not been promising.

To identify possible drug targets, the research team examined more than 1,600 previously FDA-approved drugs with known targets, says Majid Kazemian, assistant professor in the departments of computer science and biochemistry at Purdue University.

We looked at the genes that are up-regulated by COVID-19 but down-regulated by specific drugs, and Ruxolitinib was the top drug with that property, he says.

Within the last few years, scientists have discovered that the immune complement systema complex system of small proteins produced by the liver that aids, or complements, the bodys antibodies in the fight against blood-borne pathogenscan work inside cells and not just in the bloodstream.

Surprisingly, the study found that this response is triggered in cells of the small structures in the lungs known as alveoli, Kazemian says.

We observed that SARS-CoV2 infection of these lung cells causes expression of an activated complement system in an unprecedented way, Kazemian says. This was completely unexpected to us because we were not thinking about activation of this system inside the cells, or at least not lung cells. We typically think of the complement source as the liver.

Claudia Kemper, senior investigator and chief of the Complement and Inflammation Research Section of the National Institutes of Health, was among the first to characterize novel roles of the complement system in the immune system. She agreed these latest findings are surprising.

The complement system is traditionally considered a liver-derived and blood-circulating sentinel system that protects the host against infections by bacteria, fungi, and viruses, she says. It is unexpected that in the setting of a SARS-CoV2 infection, this system rather turns against the host and contributes to the detrimental tissue inflammation observed in severe COVID-19. We need to think about modulation of this intracellular, local, complement when combating COVID-19.

Ben Afzali, an investigator of the National Institute of Healths National Institute of Diabetes and Digestive and Kidney Diseases, says there are now indications that this has implications for difficulties in treating COVID-19.

These findings provide important evidence showing not only that complement-related genes are amongst the most significant pathways induced by SARS-CoV2 in infected cells, but also that activation of complement occurs inside of lung epithelial cells, i.e., locally where infection is present, he says.

This may explain why targeting the complement system outside of cells and in the circulation has, in general, been disappointing in COVID-19. We should probably consider using inhibitors of complement gene transcription or complement protein activation that are cell permeable and act intracellularly instead.

Afzali cautions that appropriate clinical trials should be conducted to establish whether a combination treatment provides a survival benefit.

The second finding that I think is important is that the data suggest potential benefit for patients with severe COVID-19 from combinatorial use of an antiviral agent together with an agent that broadly targets complement production or activation within infected cells, he says. These data are promising, but it is important to acknowledge that we carried out the drug treatment experiments in cell lines infected with SARS-CoV2. So, in and of themselves they should not be used to direct treatment of patients.

Kemper adds that the unexpected findings bring more questions.

A currently unexplored and possibly therapeutically interesting aspect of our observations is also whether the virus utilizes local complement generation and activation to its benefit, for example, for the processes underlying cell infection and replication, she says.

Source: Purdue University

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Growth Drivers of Biochemistry Analyser Market 2020-2027 based on Key Players Like Thermo Fisher Scientific, RMS, HORIBA SoccerNurds – SoccerNurds

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Global Bench-top Veterinary Biochemistry Analyzers Market 2020 2025 Qualitative and Quantitative Assessment by Industry Analysis across the Value…

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