Category Archives: Biochemistry

Dr. Richard McCann Appointed Assistant Dean of Faculty Affairs and Professional Development – Mercer News

MACON Dr. Jean R. Sumner, dean of Mercer University School of Medicine (MUSM), recently announced the appointment of Dr. Richard McCann as assistant dean of faculty affairs and professional development.

Working with Dr. Marie Dent, associate dean of faculty affairs and professional development, Dr. McCann will continue providing guidance and professional development opportunities for faculty, said Dr. Sumner. Dr. McCann is a proven leader, scientist and outstanding teacher who embodies a commitment to students, colleagues and the mission of Mercer University School of Medicine.

Dr. McCann, a native of Brunswick, graduated from Glynn Academy and earned his B.S. in biochemistry and Ph.D. in biochemistry and molecular biology from the University of Georgia. He was an American Heart Association Postdoctoral Research Fellow at Johns Hopkins University School of Medicine in the Department of Biological Chemistry.

Prior to joining Mercers faculty in 2008, Dr. McCann was an assistant professor of biochemistry at the University of Kentucky College of Medicine in Lexington.

He currently serves MUSM as an associate professor of biochemistry.

Throughout his career, Dr. McCann has combined a research program on cell adhesion withteaching. He advised three Ph.D. students and one M.D./Ph.D. student at the University of Kentucky. He also taught cell biology, genetics and biochemistry in the Master of Science in Biotechnology Program at Johns Hopkins and in the Integrated Biomedical Sciences Program at Kentucky.

At Mercer, Dr. McCann has served as a tutor in the first-year medical curriculum, and from 2011-2015, he was phase coordinator for the cellular basis of medicine in the Biomedical Problems Program curriculum. He is currently Block 1 co-chair for the Macon Campus in the revised Patient Based Learning curriculum.

Dr. McCann is the founding director of MUSMs Master of Science in Biomedical Sciences, and for the next three years, he will chair the Cell Structure and Survival Review Panel for the American Heart Association.

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Dr. Richard McCann Appointed Assistant Dean of Faculty Affairs and Professional Development - Mercer News

Rowan staff and students mourn loss of chemistry professor Timothy Sheehan – The Whit Online

Adjunct and three-quarter time Rowan professor Timothy Sheehan diedon Feb. 13, according to a Rowan Announcer Extra Edition email sent to facultyTuesdayevening.

Sheehan was a professorin the chemistry and biochemistry department and worked at Rowan since spring 2009, according toGregory Caputo, chemistry and biochemistry department chair.

According to Caputo,Sheehan taught two general chemistry courses as well as an advanced college chemistry series.

One thing that always stood out about Tim was that he was always really positive and really upbeat and energetic and really brought that into the classroom, Caputo said in a phone interview. [His passing] came as a real shock to all of us.

According to his obituary from legacy.com, Sheehan was a father, husband and grandfather from Mt. Laurel, New Jersey. He died age 66 from natural causes.

Assistant professor of chemistry and biochemistry Tim Vaden was similarly shocked and saddened by the news of Sheehans death.

Up until last week, he seemed healthy and normal, Vaden said. He was very positive and never complained about anything at all.

Vaden admiresSheehan for his reliability, saying, Whether it was 8 a.m. or evening classes, he was always open to whatever we needed him to do, with a smile on his face.

Along with the faculty, Rowan students shared positive remembrances about Sheehan as an individual.

Sophomore biology major Jenn Hopkins, who had Sheehan for Chemistry 2, appreciated his frequent anecdotes.

He shared a lot of stories and experiences about his work in chemistry throughout the class, which made it really interesting to learn from him, she said.

Freshman biochemistry major Justin Roldan respected Sheehans affability and clarity.

He was always friendly, like a grandpa figure to the class, Roldan said. Even if the lessons would get confusing, professor Sheehan would take time to make the lessons more relatable and talk about his past experiences in pharmaceutical companies.

Roldan added that two grieving counselors were available for his class during lecture period.

Freshman biochemistry major Edward Taggart, paralleled the comments expressed by others, touching on Sheehans helpful nature, extensive experience and the feelings of grief that have come as a result of hisdeath.

He was a kind man with a lot of personality, and it came as a great shock to me and the entire class the morning after he passed. Im just more at a loss for words, and hoping the rest of the semester proceeds as he would have wanted, he said.

Additional reporting by Justin Decker.

For comments/questions about this story, email news@thewhitonline.com or tweet @thewhitonline.

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Rowan staff and students mourn loss of chemistry professor Timothy Sheehan - The Whit Online

SSCI Expands Biochemistry Services to Meet Growing Industry … – Benzinga

Intended to meet rapidly growing needs of the biopharmaceutical sector

WEST LAFAYETTE, Indiana (PRWEB) February 16, 2017

SSCI, a division of Albany Molecular Research Inc. has further extended its industry leading Biochemistry Services specifically targeting the rapidly growing needs of the biopharmaceutical sector. This service offers state-of-the-art cGMP techniques and methods for the biochemical and biosimilar characterization, product-related impurity characterization, aggregation state characterization, structure elucidation, protein formulation development, comparability, analytical method development and validation, and protein and peptide crystallization. Included in the diverse array of services available, an ultra-high resolution Q-TOF mass spectrometry is the cornerstone a state of the art instrument that significantly enhances SSCI's capabilities in analysis and data interpretation for large molecules, including biologic drugs such as antibodies and antibody-drug conjugates, metabolites and polymers to meet the expectations outlined in the ICH Q6B Specifications: Test Procedures and Acceptance Criteria for Biotechnological/ Biological Products.

"Innovative proteins and biopharmaceuticals comprise the fastest growing class of new chemical entities in the industry," commented Patrick Tishmack, PhD, Director Analytical Development , who leads the Biochemistry Services at SSCI. "Many of these therapeutic proteins typically exist in the solid state as lyophilized powders during their manufacture or in a final formulation. Few proteins are produced as crystals or formulated as mixtures of crystalline and amorphous protein. Therefore, SSCI is uniquely positioned to provide an understanding of the properties of biologics in the solid-state or as liquid formulations, which is of critical importance both in the development of the product and for regulatory approval."

About SSCI SSCI, a division of Albany Molecular Research Inc., provides industry leading contract solid-state and analytical testing services and exists to help companies in the pharmaceutical, food, agrochemical, and other chemical industries develop better products and get them to market more quickly. Over the past quarter century, SSCI has provided comprehensive cGMP research and analytical services in the characterization and chemistry of solid materials, with particular expertise in small and large molecules being investigated for pharmaceutical use. As the AMRI's Center of Excellence for Solid State Chemistry, its offerings include early candidate support services (in vitro analysis, stability, solubility, dissolution, excipient compatibility), solid form screening and polymorph, salt and cocrystal screening, form selection, particle engineering (process development, particle size method development), property improvement, crystallization of difficult materials, process control, biochemical analysis, full analytical chemistry support including method development and validation, intellectual property consulting and litigation support, and related research activities.

For more information about SSCI's biochemistry services, please contact 1-800-375-2179 or visit http://www.ssci-inc.com.

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SSCI Expands Biochemistry Services to Meet Growing Industry ... - Benzinga

Chemistry Seminar by Fr. Gerald Buonopane – Seton Hall University News & Events

Wednesday, February 15, 2017

By Nicholas Snow

The Department of Chemistry and Biochemistry Rose Mercadante Seminar Series is pleased to present a seminar entitled "Effect of Cold Plasma Processing on Sweet Basil and the Chemistry of its Essential Oils" by Fr. Gerald Buonopane, Dr. Cosimo Antonacci and Dr. Jose Lopez of the Departments of Chemistry and Biochemistry and Physics of Seton Hall University.

The seminar will take place in the Helen Lerner Amphitheater, Science and Technology Center, Seton Hall University at 5:45 P.M. on Tuesday February 21, 2017. Refreshments are available at 5:30 PM.

This interdisciplinary research project, which focuses on the emerging field of plasma agriculture, seeks to better understand the chemical and physical effects of cold plasma processing on plants and their essential oils. Cold plasma processing has been shown to be a rapid, economical, and pollution-free method to improve plant seed performance and crop yield. Essential oils are aromatic oily liquids extracted from different parts of plants, such as the leaves, flowers, and roots. Among the various beneficial properties of essential oils is their demonstrated antioxidant effect directly applicable to foods that are prone to oxidative consequences such as poor flavor, bad odors, and spoilage. Antioxidants, either synthetic (e.g., butylated hydroxytoluene, BHT) or natural (e.g., Vitamin C), are routinely added to processed foods to inhibit or delay oxidation. Essential oils are examples of natural antioxidants. Although synthetic antioxidants like BHT and BHA (butylated hydroxyanisole) are very effective, they have been shown to be potentially harmful to human health with demonstrated evidence of causing cancer in laboratory animals. As a result, food scientists have been seeking alternative natural compounds as substitute antioxidants, such as essential oils. We have observed a growth effect in our preliminary studies treating basil plants with cold plasmas. We have also observed that plasma treatment increases the antioxidant activity of essential oils. Our preliminary work further revealed a difference in the composition of individual antioxidant components between the plasma-treated and non-plasma-treated basil. In follow-up studies, we seek to better understand cold plasma's physical and biochemical-molecular effects on basil plants.

Ordained as a priest of the Archdiocese of Newark in 2006, Fr. Gerry's area of specialization is food chemistry. He earned a B.S. in Biology from Northeastern University (1978), a M.S. in Nutritional Science from the University of Connecticut (1981) and a Ph.D. in Food Science from Penn State University (1988). Prior to seminary and the priesthood, Fr. Gerry held a number of positions in academia, the federal government (USFDA), and in the food and pharmaceutical industries. His research areas of interest are: Chemical Deterioration of Food Lipids: Oxidative Reactions; Essential Oils as Natural Antioxidants; and Cold Plasma Treatment of Botanicals and Essential Oils.

Dr. Cosimo Antonacci holds BS and PhD degrees in Chemistry from Seton Hall University. He is currently Undergraduate Laboratory Manager in the Department of Chemistry and Biochemistry, where he supervises all activities in the department's teaching laboratories. He is an active researcher in biochemistry with ongoing collaborations in Biochemistry, Biological Sciences and Physics.

Professor Jose L. Lopez is an Associate Professor in the Department of Physics at Seton Hall University in South Orange, New Jersey, USA. He earned a B.S. in Physics from Saint Peter's University in Jersey City, New Jersey in 2000, an M.S. in Physics in 2003 and a Ph.D. in Physics in 2006 from the Stevens Institute of Technology in Hoboken, New Jersey.

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Chemistry Seminar by Fr. Gerald Buonopane - Seton Hall University News & Events

Roses are red, violets are bluewhat gives flowers those eye … – Phys.Org

February 13, 2017 by Cheryl Dybas Knock-your-eyes-out red: A flowering plant native to Mexico called early jessamine or red cestrum. Credit: Stacey Smith

To solve the mystery of why roses are red and violets are blue, scientists are peering into the genes of plant petals.

"When you ask anyone how one flower is different from another, for most of us, color is the feature that first comes to mind," says evolutionary biologist Stacey Smith of the University of Colorado Boulder.

Most people don't think about why a flower is a particular color, but it's an important question for biologists, says Prosanta Chakrabarty, a program director in the National Science Foundation's (NSF) Division of Environmental Biology, which funds Smith's research.

Smith and her team are "looking at the genetics of flower colors, and at changes in those colors over time," Chakrabarty says.

It all comes down to biochemistry

In nature, flowers come in hues that span the rainbow.

"On a microscopic level, the colors come from the biochemical composition of petal cells," Smith says.

Pigments are the main chemicals responsible. Plants contain thousands of pigment compounds, all of which belong to three major groups: flavonoids, carotenoids and betalains. Most flower colors come from flavonoids and carotenoids.

"In addition to giving flowers their colors, carotenoids and anthocyaninswhich are flavonoidshave antioxidant and other medicinal properties, including anti-cancer, antibacterial, antifungal and anti-inflammatory activity," says Simon Malcomber, a program director in NSF's Division of Environmental Biology.

Malcomber says the research could show how plants evolved to synthesize the carotenoids and anthocyanins that produce red flowers. "The results could be used in future drug discovery research," he says.

Much of Smith's work is focused on understanding how changes in flavonoid and carotenoid biochemistry relate to differences in flower colors. She and colleagues conduct research on the tomato family, a group of about 2,800 species that includes tomatoes, eggplants, chili peppers, tobacco and potatoes.

"These domesticated species don't have a terribly wide range of flower colors and patterns, but their wild relatives often do," Smith says. "So we study wild, or undomesticated, species, which are most diverse in South America."

Hot pursuit of red-hot color

Smith has had her share of adventures in the fieldlike the time she tried to find a plant with red flowers that lives at the base of a volcanic crater in Ecuador.

"It was my very first field trip, and I wasn't super-savvy," Smith says. "I took a bus to the outside of the crater, dragged my suitcase up to the rim then down into the crater, assuming there would be a village and a way to get out. There was neither. Thankfully, there was a park station nearby where I was able to stay overnight. I found the species in full flower in the forest the next day."

Smith is currently in hot pursuit of an answer to the question: When did red flowers first appear in the tomato family? "We thought that red flowers might have evolved many times independently of each other because red-flowered species are scattered among many branches of this family tree," she says.

Just 34 species in the entire tomato family, however, have red flowers.

"With such a small number, we can take samples of every one of these species to find out whether it represents an independent origin, and to determine the biochemistry of how it makes red flowers," Smith says.

She and other biologists traveled from Brazil to Colombia to Mexico to track down red flowers and measure their pigments. "We found surprising patterns," Smith says, "including that nearly every red-flowered species represents a new origin of the color, so red flowers have evolved at least 30 different times."

While the researchers expected that flowers would be red due to the presence of red pigments, they found that plants often combine yellow-orange carotenoids with purple anthocyanins to produce red flowers.

"Our studies are now aimed at tracing the entire genetic pathway by which plants make flower colors and identifying genetic changes to see if there are common mechanisms," Smith says.

The scientists want to know, for example, what changes have taken place since flowers first became red.

Answers in a petunia

"We're focusing on a single branch of the tomato family [petunias], creating an evolutionary history and conducting measurements of gene expression, pigment production and flower color," says Smith.

Petunias and their colorful relatives are good choices for this research, according to Smith.

"Most of us have seen the tremendous variation in petunia colors at our local nurseries, and indeed, petunias have served as models for studying flower color and biochemistry for decades."

Few people, though, are aware of the variation in petunias' wild relatives, most of which are found in Argentina and Brazil. "We're harnessing this natural diversity, as well as genetic information already available from ornamental petunias, to reconstruct the evolutionary history of flower colors," says Smith.

"If earlier studies taught us anything," she adds, "we shouldn't expect flowers to play by the rules."

Will roses always be red, and violets blue?

Explore further: Turning pretty penstemon flowers from blue to red

While roses are red, and violets are blue, how exactly do flower colors change?

Flower colors that contrast with their background are more important to foraging bees than patterns of colored veins on pale flowers according to new research, by Heather Whitney from the University of Cambridge in the UK, ...

(Phys.org) -- A team of researchers in Australia has shown that the evolution of flowers in that country was driven by the preferences of bees, rather than the other way around. In their paper published in the Proceedings ...

Researchers have uncovered the secret recipe to making some petunias such a rare shade of blue. The findings may help to explain and manipulate the color of other ornamental flowers, not to mention the taste of fruits and ...

Male hummingbirds drive female birds away from their preferred yellow-flowered plant, which may have implications for flower diversification, according a study published Jan. 27, 2016 in the open-access journal PLOS ONE by ...

Roses are red, violets are blue. Everybody knows that, but what makes them so? Although plant breeders were aware of some of the genes involved, there was as yet no quantitative study of how pigment turns a flower red, blue ...

A new report from the Stowers Institute for Medical Research chronicles the embryonic origins of planaria, providing new insight into the animal's remarkable regenerative abilities.

How plant cells divide and how that contributes to plant growth has been one of the longstanding unsolved mysteries of cell biology. Two conflicting ideas have fueled the mystery.

Watching the smooth movement generated by hundreds of fish as they swim in unison is truly mesmerising. But it's not only its sheer beauty that makes it so hard to look away, for scientists, it's also the fact that its emergence ...

Recent evidence demonstrates that the origins of photosynthesis can be found in deep sea hydrothermal vents, where microbes evolved to obtain energy from ejected hydrogen sulfide and methane gases. These microbes are capable ...

A new study of songbird dehydration and survival risk during heat waves in the United States desert Southwest suggests that some birds are at risk of lethal dehydration and mass die-offs when water is scarce, and the risk ...

Scientists have discovered a new protein that likely will advance the search for new natural antibiotics, according to a study by Texas A&M AgriLife Research published Feb. 13 in the journal Nature Microbiology.

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The Biochemistry of Love and Herbal Aphrodisiacs – Lawrence, Kansas

Dive deep into this dynamic, hands-on intensive to discover the biochemistry behind love, arousal, connection, and the medicinal plants that can aid us in these completely natural and healthy processes. We will look in-depth at six different powerful aphrodisiac herbs, the phytochemistry of how they work in the body, contraindications, and practical ideas for application. We will finish the class with smelling, tasting and finally making our own Damiana Cordial to take home. Class is taught by Shannon Ryan, Professional Herbalist and Licensed Acupuncturist. Note: While beginners are welcome, content is most suitable for attendees with some basic knowledge of herbal medicine.

~ $35 ~ *Space is Limited and Pre-Registration is Required*

* Call Lawrence Acupuncture to Register (785) 371-1141 or book online at http://www.lawrenceacupuncture.com

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Laurie Stargell named chair of Department of Biochemistry and … – Colorado State University News (press release)

The Department of Biochemistry and Molecular Biology baton has been passed into the hands of Professor Laurie Stargell, who is ready to go full speed ahead as the new chair of that department in Colorado State Universitys College of Natural Sciences.

Laurie Stargell, professor and department chair, biochemistry and molecular biology

Stargell strives to continue her mentoring, to grow and strengthen her department ranks, and to develop new programs and ideas. But these are just the start to her plans as department chair. She said, I feel strongly that we should empower our people, whether they be faculty, staff or students, with the knowledge and skills they need to succeed.

Stargell earned her B.A. in biology at the University of Virginia in 1986. She then went on to become a pre-doctoral fellow at the University of Rochester, where she received her Ph.D. in biology. There, she began studying basic machinery for RNA polymerase II transcription. This led into her research with chromatin, histone variants, and transcription processes in the model organism Tetrahymena.

After completing her studies at Rochester, Stargell began her postdoctoral research in genetics at Harvard Medical School and finished in 1996. As a postdoctoral fellow, she became fascinated by the power and breadth of approaches available in the yeast system for understanding mechanisms of transcriptional regulation, which she continues to make headway on today.

Stargell has been a part of CSU for the past 20 years and is committed to mentoring and providing research opportunities for students at all levels. She started out as an assistant professor in 1996, and moved up to associate professor in 2002. She has been the associate chair for undergraduate studies since 2006 and is involved in creating curriculum, advising, and helping with the scholarship processes for the growing undergrad population in biochemistry and molecular biology.

In 2008, she became a full professor in the Department of Biochemistry and Molecular Biology and continues to teach introduction to genetics, molecular genetics, a biochemistry seminar, and molecular biology. Thanks to her research and her ability to mentor at CSU, past students have reached career goals and now hold positions in academia and in the field.

She is also the chair of the board of directors for the Institute of Genome Architecture and Function. She has received honors from CSU such as the Jack E. Cermak Advising Award, CNS Professor Laureate, and Oliver P. Pennock Distinguished Service Award. She was also awarded, along with fellow CSU professor Jennifer Nyborg and former CSU professor Karolin Luger, a $7.8 million grant from the National Institutes of Health to study how chromosomes unravel to depict genes that dictate cell behavior.

Stargell also started an elementary outreach program along with fellow CSU Associate Professor Eric Ross, to get young students excited about science. Biochemistry is Elementary, is an eight-week-long program that has engaged over 600 fifth graders. It allows students to get hands on experience introducing genetics and biochemistry, while showing the value of studying model systems.

With a new chair being filled, the department looks ahead to keep research and advancement growing in the Department of Biochemistry and Molecular Biology under new chair, Laurie Stargell.

The College of Natural Sciences extends its gratitude to Shing Ho who has been the departments chair for the last 10 years. As he returns to his faculty position, the department appreciates the progress he made during his time as chair. Biochemistry and molecular biology is now the fourth largest major in the college. And as of 2016, the entering class was 130, pushing majors to over 300 students. Whats more, its faculty continue to produce groundbreaking research.

Stargell sees her role as continuing this success. She said, Each member of our department, whether faculty, staff, or student, is important and essential, and together we are responsible for the overall health and welfare of the department.

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Chemistry & Biochemistry | College of Letters & Science

A Search-and-Destroy Strategy for Killing Tumors

March 12, 2015 1:24 pm

One of Chemistrys Assistant Professors, Dr. Xiaohua Peng, was featured in the 2015 edition of the UWM Research Report. Current cancer drugs do not distinguish between malignant cells and healthy ones. In order to destroy tumors, drugs must target all... Read more

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Chemistry & Biochemistry | College of Letters & Science

Biochemistry professor continues to follow passions at 100 years old – The Maneater

Eighty years ago, professor emeritus of biochemistry Boyd ODell began taking classes at MU. Now 100 years old, ODell, who has made many discoveries and inspired generations of colleagues, can still be found in his office in Eckles Hall.

I have some questions I really would like to answer, and Id rather think about answering those questions than retiring, ODell said.

ODell technically retired in 1988, but still does part-time research on campus.

In September, a celebration honoring the 40th anniversary of the biochemistry department served as an early 100th birthday party for ODell. In December, a plaque was unveiled, naming the bridge connecting Schweitzer Hall to the Schlundt Annex the Boyd ODell Bridge of Discovery.

I hope the bridge will be a bridge to the future for all the students and progress will be made in research and learning, ODell said at the unveiling.

Over the years, ODell has served as a mentor and a friend for many of his colleagues and students. Biochemistry professor Judy Wall first met ODell when she joined the MU faculty in 1978.

Hes an incredible gentleman, very professional, a great scholar and a truly kind person, Wall said.

Wall remembers when she and ODell were assigned to evaluate a graduate students grant proposal for a comprehensive exam. This was Walls first time evaluating this type of exam, and the only other female faculty member in the department did not attend their presentations.

I was the sole female faculty member and, you know, a silly person who was in the process of thinking about impressing all of my peers and making sure they didnt think I was an idiot at the evaluations, Wall said. So I was all set for getting this guy because I didnt think his proposal was great.

ODell went first. He discussed the importance of the problem the student had addressed and the strengths of the work before introducing criticism.

That was a wonderful experience for me because I thought thats exactly the way you should do it, Wall said. You have to earn the right to criticize by showing that you understand whats going on and you have to earn the right to begin to make constructive suggestions. Dr. ODell had shown me that was the professional way of going about it.

Wall uses this same approach anytime she has to evaluate anything in a similar manner.

He didnt realize, and I dont think I realized at the time, that he was mentoring me, but he certainly was, Wall said.

ODell decided to pursue education because he admired his teachers, who were his first role models.

I always had an ambition to be a teacher, ODell said. What did a farm boy in Carroll County have as role models? There was two things that I can think of, teacher was the most obvious one, and veterinarian.

ODell was born on a farm outside of Hale, Missouri, on Oct. 14, 1916. Becoming a veterinarian wasnt an option he considered, because it wasnt a financial possibility.

My parents were just poor farmers, and they couldnt help me, he said. I had to pave my way.

The summer after he graduated high school, ODell took an examination to become a teacher.

I passed all subjects with high scores except one, and that was pedagogy, ODell said. I didnt even know what pedagogy was. I suppose its the art of teaching.

That summer, ODell took classes at the University of Central Missouri, which was known as Warrensburg Teachers College at the time. He then began working in a one-room schoolhouse, where he taught first through eighth grade.

It was kind of fun in retrospect, ODell said. And that was in the depths of the Depression, to be paid $50 a month was a very good job. A lot of people were unable to even find a job.

Because he wanted to continue his education, ODell left the grade school after four years.

After a few years I transferred to the university here and got jobs one way or another and was able to support myself, he said.

He wanted to study bacteriology, but MU didnt have a program, so ODell was advised to become a chemistry major.

I worked for Dr. A.G. Hogan, who was my mentor for my Ph.D. At that time, he was interested in a vitamin that now is known as folic acid, ODell said.

ODell went on to work for a pharmaceutical company in Detroit after receiving his degree. With the end of World War II, MU saw an increase in students and invited ODell back to become a professor.

Coming back to Mizzou was kind of an easy choice because that was home. Im a Missourian through and through, ODell said.

ODell then studied the existence of unknown vitamins as an assistant professor.

At that time, an assistant professor was really an assistant to the professor, ODell said. When I became a little further along and had the independence, I still followed the question of, are there still unknown vitamins?

ODell went on to study the role of copper and zinc in the body. Among his discoveries was the revelation that copper deficiencies in animals can cause death through the rupture of the aorta, in the heart.

The opportunity arose for me to go on a sabbatical to Australia, ODell said. And why would I want to go to Australia? If youre interested in copper, its the place to go because much of the soil in Australia is copper-deficient.

In Australia, ODell saw that copper deficiency in sheep can cause symptoms similar to Parkinsons disease. He later observed the same results in rats.

We became interested in zinc deficiency around the same time, ODell said. We found that zinc deficiency in animals stops growth and causes increased subject to disease. Diarrhea is a common complaint of zinc-deficient animals and children.

He then discovered that phytic acid, which appears in plants such as soybeans and corn, can actually impact the way the body absorbs zinc.

Scientists want to know why does zinc deficiency cause these signs and symptoms in humans and animals, ODell said. Ive been interested in trying to solve that question for quite a number of years.

ODell is currently researching the importance of zinc in maintaining calcium channels.

If you think back of all the factors that a cell does, a cell divides, a cell secretes, contracts and carries messages, ODell said. All of this is dependent on a calcium channel, and if you take away zinc, the channel fails and you get all these symptoms. I think that that is the true, fundamental function of zinc to maintain the calcium channel.

ODell and Wall, a professor of biochemistry, have since worked together on a variety of committees and both taught biochemistry to first-year medical students.

He was always incredibly prepared, just beautiful lectures and so absolutely timely, Wall said. He knew the literature and was just great.

Another of ODells colleagues, professor emerita of biochemistry Grace Sun, also spoke of ODells role as a mentor.

Right now, Ive been retired for two years only and hes been retired for many more years, Sun said. I would say that hes a role model for me, and I wish I could do half as much like him.

The two became friends in the 80s, when a colleague Sun had met while working as a visiting professor in Taiwan came to MU to study with ODell.

ODell and his wife used to throw parties around the holidays where they would serve American foods, Sun said.

We loved it because we have a lot of international students and he has always a group of them, Sun said. At the time, he was like a hub for the international students.

Sun says ODell still interacts with colleagues and former research assistants by attending seminars and events on campus.

I remember one time, this must have been four or five years ago, and hes way over 90 and he wrote me an email, Sun said. He read a paper and then he said, Hey, Grace, maybe we can work together to do something on this area. I was so shocked. I was really amazed how he must be reading a lot of papers at home or in his office.

Now, ODell does experiments once or twice a week with cells that are grown in the Life Science Building.

I asked to use the equipment and I think they decided they better volunteer to do some of the work rather than trust me, ODell said with a laugh.

An undergraduate was assigned to help ODell grow and transfer the cells, Wall said.

It came holiday time, and the undergraduate was coming up on holiday, and so instead of imposing on this woman, Boyd decided he would just teach himself how to culture the human tissue culture, and so he did it, Wall said. Every day he would come over and transfer his cells and work with his cells. He walks over form Eckles to the Life Sciences Center and back again and has learned how to do this. What a terrifically fearless person he is when it comes to science.

ODell doesnt just walk across campus; he also walks from his house every time he comes to do research.

Most of my career I rode a bicycle to work, ODell said. I dont have a car, and I dont ride my bicycle anymore that leaves walking. I like walking. I think its good exercise, and I need exercise.

ODells daughter Ann, who lives in Columbia, helps drive him when he needs to go shopping and eats with him every week. ODell has a son, David, who lives in California, as well as four grandchildren and two great-grandchildren.

Outside of science, ODells hobbies include photography and bird-watching.

I was always interested in bird-watching and nature work; I guess that might fall from the science, ODell said. Even when I was teaching at the grade school, I had projects for the kids where wed collect plants.

After 100 years, ODell recognizes the importance of lifelong learning and following ones interests.

I think you should, in general even beyond science, you should pick a job or do what you have a real passion for, ODell said. I think if you really are keenly interested in it you will be successful.

Edited by Kyle LaHucik | klahucik@themaneater.com

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Biochemistry professor continues to follow passions at 100 years old - The Maneater

Sumo protein explored as likely source for some congenital heart defects – Medical Xpress

February 7, 2017 by Brandi Klingerman Professor Paul Huber. Credit: University of Notre Dame

Small ubiquitin-like modifier (SUMO) proteins are small peptides that get added on to other proteins to regulate their activity. While SUMO has many regulatory roles in cells, it is especially important for controlling gene expression during early development. Just a few years ago this connection between SUMO and gene regulation was relatively unknown, but now, Notre Dame researchers are exploring how a disruption to the SUMO protein's ability to regulate embryo development may be linked to congenital heart defects.

Paul Huber, professor of chemistry and biochemistry, and Norman Dovichi, the Grace-Rupley Professor of Chemistry and Biochemistry, are working together to understand the role of all proteins in embryo development using Xenopus laevis or the African claw frog. This species is known for having a similar gene structure to that of the human genome, meaning that findings related to this species have the potential to provide a deep understanding about human diseases.

When discussing their research, Dovichi said, "In 2014, Huber and I completed a study using Xenopus laevis embryos to understand how more than 4,000 proteins fluctuate during the different stages of development. We found that certain proteins spike or lower during specific stages. For example, a number of proteins that are used during the creation of cardiovascular tissue rose during stage 13, when organs develop."

In these early experiments, Huber found that when SUMO activity was repressed, many of the embryos had two predominate phenotypes, one of which was heart defects. Then, new studies began linking mutations in SUMO protein to heart failure as well as congenital heart defects. This is when the Notre Dame researchers began to develop the next steps for their research.

"At the time, there was not a lot of information about the role of the SUMO protein, but our theory was that it was critical for proper development of the heart," said Huber. "To study the protein's specific impact, we inhibited SUMO activity in the developing cardiovascular tissue. This will allow us to compare the proteome or all of the proteins that are expressed by a cell of the defective hearts with their normal counterparts."

To support the research, Olivia Cox, a Notre Dame graduate student, collaborated with Daniel Weeks, professor of biochemistry and pediatrics at the University of Iowa, and identified three predominate heart defects in the SUMO-deficient hearts: septal defects commonly thought of as holes in the heart abnormal turning of the outflow tract, and noncompaction cardiomyopathy.

The goal of this research is to use the proteome comparisons to specifically identify which proteins are responsible for congenital heart defects. Additionally, Huber, affiliated with the Harper Cancer Research Institute (HCRI) and the Center for Stem Cells and Regenerative Medicine, and Dovichi, affiliated with Advanced Diagnostics and Therapeutics as well as the HCRI, plan to continue exploring the SUMO protein's significance in other areas of embryo development. This research could help explain why other development defects arise, and eventually lead to a solution for increasing SUMO protein expression when a mutation occurs.

Explore further: SUMO-snipping protein plays crucial role in T and B cell development

More information: Liangliang Sun et al. Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development, Scientific Reports (2014). DOI: 10.1038/srep04365

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Sumo protein explored as likely source for some congenital heart defects - Medical Xpress