December 09, 2019

A scientist whose research has transformed our understanding of Australias iconic mammals has been recognised by the Australian Academy of Science. Professor Marilyn Renfree AO FAA has been awarded the Academys highest honour in the biological sciencesthe Macfarlane Burnet Medal and Lecture.

For half a century the committed reproductive and developmental biologist and conservationist from the University of Melbourne has been using the tammar wallaby, a small macropodid marsupial native to South and Western Australia, to study their reproduction and development.

Professor Renfree has developed contraceptive strategies for kangaroos and koalas and established marsupials as unique biomedical models for understanding human reproduction.

She is now a world authority on marsupial reproduction and development and has pioneered research on some of Australias most iconic creatures including kangaroos, koalas and now echidnas.

And with passion for her work as strong as ever, she has no plans of slowing down. Professor Renfree has just embarked on the worlds first study of the development of the embryo and newly hatched pouch young from the echidna.

Professor Renfree said hardly anything was known about marsupials when she started out.

Im passionately Australian and I really wanted to work on something Australian but when I started honours I said to my prospective supervisors: I wanted to do biochemistry and fieldwork. And they laughed at me. Well, Im still really doing biochemistry and fieldwork.

Her first paper published from her PhD in 1972 was aNaturepublication.

In her distinguished career Professor Renfree has made numerous research breakthroughs. In research with colleagues Professor Renfree conducted the first genome sequencing of an Australian marsupial, the tammar wallaby, providing new information on their evolution.

She also showed that certain genes directly control sexual development during pregnancy and even after birth in marsupials, providing a new understanding of the relative influence of genes versus hormones in sexual differentiation in all mammals. With colleagues she also discovered a new hormone pathway that explains some human disorders of sexual development.

Professor Renfree said Australia is sitting on a biological goldmine because it is home to a unique assembly of mammalsthe marsupials and monotremes.

The impact of Australias recent bushfires on Australian mammals has highlighted Australia and the worlds fascination with these special animals. We really need to put more effort, time and money into conserving and doing research on them, Professor Renfree said.

Australia has the distinction of having the worst record of mammal extinctions of any developed country and thats not a record you want to be proud of.

Professor Renfree said the Academy award is a huge honour.

Im receiving it on behalf of all of my students, PhD students and postdocs and collaborators. Without them I could have only done a fraction of what I've done, Professor Renfree said.

She was nominated for the medal by Professor James Angus FAA from the University of Melbourne.

Professor Renfree is a pioneer and forward thinker who has an ability to excite and inspire scientists from around the world by providing new insights through the study of the unique evolutionary innovations in the reproductive systems of marsupials and monotremes, Professor Angus said.

The basic science and the clinical impact of her work for humans are as important as the direct benefits of her work for Australias marsupials. Her research has undoubtedly opened the eyes of the academic world and beyond to the value of these iconic Australian mammals both for their intrinsic interest and as unique biomedical models.

Professor Renfree will receive the medal and give a lecture at the Academys Science at the Shine Dome event in May 2020. The Macfarlane Burnet Medal and Lecture honours the contributions to science by Sir MacFarlane BurnetOMKBMDFAAFRSNobel Laureate.

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Researcher who uncovered the sex life of marsupials awarded Academy's most prestigious medal - Australian Academy of Science

GlobalBiochemistry Analyzers Market: Overview

The report details an exhaustive account of the global biochemistry analyzers market along with numerous associated factors. Some of these factors that are included in the report are drivers, restraints, competitive analysis, latest trends and opportunities, geographical outlook, and many other aspects. The study covered in the report spans a forecast period from 2018 to 2028. From an overall perspective, the report is expected to exist as a valuable insight to businesses which are already operating in the global biochemistry analyzers market, as well for those who intend to newly establish themselves in this environment.

GlobalBiochemistry Analyzers Market: Market Potential and Restraints

Widespread advancements in the medical field have primarily been responsible for driving the global biochemistry analyzers market. Moreover, with rising geriatric population, the numbers of health issues are gradually increasing, thereby increasing demand for relevant treatments that involve biochemical analyzers. In addition, these analyzers possess a high rate of identification of a specific pathogen, consequently providing high clarity and accuracy.

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These characteristics make the use of the biochemical analyzers more suitable than other alternatives, thereby boosting growth in the global biochemical analyzers market. Technological advancements are expected to increase even more in the near future, consequently projected to further stoke expansion in the global biochemical analyzer market. Increasing use of the analyzers in drug monitoring, drug abuse detection, and drug provision, owing to rise in the number of health conditions too is notably contributing towards growth witnessed by the global biochemistry analyzers market.

However, this market is hindered owing to several factors. A prominent obstacle present in its growth involves lack of expertise and shortage of necessary manpower required to provide the treatments that involves use of biochemistry analyzers in remote and underdeveloped regions. Owing to this, the market remains restrained geographically. Moreover, high costs of manufacturing the analyzer compounds might cause difficulties for small-scale healthcare centers to afford the required equipment.

In addition, there are several complexities involved with carrying out medical processes that make use of the analyzers. Due to this, people might prefer traditional and cheaper alternatives, which is notably hampering progress in the global biochemistry analyzers market. Nonetheless, key players are soon expected to introduce cost-effective analyzer production procedures, thus blanketing most restraints affecting the global biochemistry analyzers market.

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GlobalBiochemistry Analyzers Market: Geographical Outlook

This market is mainly spread across North America, Europe, Asia Pacific, the Middle East and Africa, and Latin America. Of these, a strong medical infrastructure in North America has made this region hold a leading stance with maximum market share. Many organizations are growing in the global biochemistry analyzers market in North America owing to the availability of necessary funds, mainly to conduct research and develop new and efficient treatments. However, apart from North America, Asia Pacific too showcases a splendid growth present in the global biochemistry analyzers market. This is majorly due to the introduction and utilization of various treatment procedures wherein biochemistry analyzers play a huge role. In addition, several companies are pouring extensive investments in developed economies located in Asia Pacific, which is anticipated to strengthen the market in this region.

GlobalBiochemistry Analyzers Market: Competitive Landscape

This market depicts the presence of a substantially competitive vendor landscape, with the presence of a handful of players exerting their respective dominance. Regulation of treatment costs, achieving geographical expansion, and bringing forth medical treatment efficiency are key strategies implemented by most players operating in the global biochemistry analyzers market. Abbott Diagnostics Inc., Hologic, Inc., Transasia Biomedicals Ltd., Beckman Coulter Inc., Roche Diagnostics GmbH, Siemens AG, Randox Laboratories Ltd., Awareness Technology, Inc., Shenzhen Mindray Bio-Medical Electronics Co., Ltd., and Nova Biomedical Corp., are chief players operating in this sector.

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Biochemistry Analyzers Market to Receive Overwhelming Hike in Revenues by 2026 - Montana Ledger

The importance of proteostasis is becoming increasingly apparent as disrupted proteostasis and dysregulation of proteostasis-associated networks has been linked with aging and many age-associated diseases such as Alzheimers, Parkinsons and Huntingtons disorders. In recognition of the importance of this subject, PLOS ONE, alongside PLOS Biology, launched a Call for Papers on the topic of Autophagy and Proteostasis earlier this year. We welcomed a range of submissions that provided insight into the molecular and cellular machinery, and mechanisms that regulate autophagy and the crosstalk of this process with other protein quality control pathways to ensure proteostasis. These studies also underline the importance of all these cellular pathways in pathophysiological conditions and aging. The Guest Editors are Sharon Tooze (Francis Crick Institute, United Kingdom), Fulvio Reggiori (University Medical Centre Groningen, The Netherlands) and Thorsten Hoppe (Institute for Genetics and CECAD Center for Aging Research, University of Cologne, Germany).

We are happy to launch this Collection today, which includes five studies published in PLOS ONE that highlight the relevance of autophagy and other pathways such as the ubiquitin proteasome-system in maintaining protein homeostasis. In human cells, Ferreira et al. showed that when the STUB1/CHIP ubiquitin ligase is inactivated, cells increase secretion of extracellular vesicles (EVs) enriched in ubiquitylated or stabilized proteins, suggesting that cells use these EVs to dispose of proteotoxic material. Studying another E3 ubiquitin ligase, Si and colleagues investigate the mechanism for Pink1- and Parkin-mediated mitophagy in indirect flight muscles in Drosophila melanogaster, and showed that Pink1/Parkin are crucial for muscle function in aged muscles in an Atg1-dependent manner. Autophagy also plays crucial roles in the fungus Aspergillus niger and Kaur and Punekar revealed that acidogenic growth appears to mimic a nutrient deficient condition, and acidogenic growth and metabolism are compromised in atg1 and atg8 strains of A. niger.

In addition, two papers in the Collection showcase research investigating proteostasis dysfunction in disease states, and potential ways to modulate autophagy for therapeutic uses. Aviazidis et al. study proteostasis network dysfunction caused by unbalanced karyotypes using human Downs syndrome fibroblasts, showing that decreased abundance of SNARE family members STX17 and VAMP8 maybe responsible for reducing autophagic flux by impairing autophagosome-lysosome fusion. Bhaskar et al. identify lipoarabinomannan (LAM), a crucial lipid component of the Mycobacterium indicius pranii cell-wall, as an inducer of autophagy that leads to the enhancement of co-localization between Mycobacteriaum tuberculosis and phago-lysosomes, and increased clearance of this bacterium in macrophages.

Papers will continue to be added to the Collection as they are published. Stay tuned for new articles and additional insights on this important topic.

Fulvio Reggiori

Fulvio Reggiori is a Professor and Section Head of Molecular Cell Biology at the Department of Biomedical Sciences of Cells and Systems of the University Medical Centre Groningen, The Netherlands. Fulvio obtained in his PhD in Biochemistry from the University of Fribourg, Switzerland, in the laboratory of Professor Andreas Conzelmann. Subsequently, he moved to the MRC Laboratory in Molecular Biology in Cambridge to join the laboratory of Dr. Hugh Pelham, UK in 1998. In 2001, Fulvio moved to the University of Michigan in Ann Arbor, USA to the laboratory of Professor Daniel Klionsky, where he started working on different aspects of the molecular mechanisms of autophagy in yeast. In 2005 he was appointed as an Assistant Professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands before becoming an Associate Professor in 2011. Fulvio moved his lab in 2015, to the Department of Department of Biomedical Sciences of Cells and Systems of the University Medical Center Groningen where he became Professor. His research continues to investigate the molecular mechanisms of autophagy using Saccharomyces cerevisiae as a model organism as well as understanding the interaction between autophagy and pathogens, in particular viruses.

Sharon Tooze

Sharon Tooze is a Senior Group Leader at the Francis Crick Institute, London, UK. She has a long-standing interest in understanding organelle biogenesis using molecular cell biology approaches. Sharon received her PhD and undertook a postdoctoral research position in Wieland Huttners lab at the European Molecular Biology Laboratory (EMBL). She established a lab at Imperial Cancer Research Fund, UK which later became known as the Cancer Research UK London Research Institute. In 2015 she moved her lab to the Francis Crick Institute where her research continues to focus on autophagy. Her current interests are focused on expanding our knowledge of the core autophagy proteins in mammalian cells at the molecular level, in particular the autophagy proteins which initiate the formation of the autophagosome.

Thorsten Hoppe

Thorsten Hoppe is a Professor at the Institute for Genetics and the Center for Aging Research (CECAD) at the University of Cologne, Germany. He received his PhD from the University of Heidelberg working in the lab of Stefan Jentsch at the Center for Molecular Biology in Heidelberg (ZMBH) and the Max Planck Institute of Biochemistry in Martinsried. He undertook is postdoctoral work in the Department of Molecular Neurogenetics in the group of Ralf Baumeister at the LM-University of Munich before setting up his own group in 2003 at the Centre for Molecular Neurobiologie at the University of Hamburg (ZMNH). In 2008 he moved his lab to the Institute for Genetics and was Acting Director from 2011 to 2013. His research focuses on understanding the role proteostasis plays in aging and age-associated diseases.

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Introducing the Autophagy and Proteostasis Collection - PLoS Blogs

Chieko Hara, University Relations

From left, Dan Sui, vice chancellor for research and innovation; Roger Koeppe, Distinguished Professor of chemistry and biochemistry; and Robert "Bobby" McGehee, executive director of Arkansas Biosciences Institute and dean at UAMS Graduate School

Science and engineering researchers at the University of Arkansas use research awards from the Arkansas Biosciences Institute to improve the health of Arkansans and prevent smoking-related illnesses.

Seed funding from the institute, a statewide consortium consisting of five research institutions, often enables researchers to produce preliminary results that help them and the university compete for large grants from federal agencies, such as the National Science Foundation and the National Institutes of Health.

As the U of A's institutional director and ABI representative for 11 years, Roger Koeppe, Distinguished Professor in the Department of Chemistry and Biochemistry, helped many colleagues secure funding from the institute. Koeppe was recognized for his service Thursday during a faculty town hall meeting to discuss future funding priorities and strategies of the Arkansas Biosciences Institute. The meeting was hosted by Dan Sui, vice chancellor for research and innovation.

"ABI funds have made a huge difference on this campus, certainly in terms of biosciences research, but also as leverage to attract and recruit top investigators," Sui said. "Obviously, Roger has been responsible so much its success on this campus, and we want to recognize his enormous contribution."

Earlier this semester, Chancellor Joe Steinmetz appointed Sui to serve as the new ABI institutional director.

The Arkansas Biosciences Institute was established as a result of Arkansas' share of the 1998 nationwide tobacco settlement. Health care leaders in the state sought a productive way to disperse the state's share of the settlement. TheArkansas Biosciences Institutewas created as a conduit for research that could help reduce or prevent smoking-related illnesses.

Arkansas voters endorsed the proposed Tobacco Settlement Proceeds Act of 2000, and the Arkansas Legislature enacted the provisions of that proposal as Acts 1569 through 1580 of 2001. Part of that legislation established the institute as a consortium of five research institutions: the University of Arkansas, the University of Arkansas System Division of Agriculture, the University of Arkansas for Medical Sciences, Arkansas State University and Arkansas Children's Hospital. Since ABI's beginning, scientists at these institutions have focused on biomedical and agricultural research with medical implications.

Robert "Bobby" McGehee, executive director of the Arkansas Biosciences Instituteand dean at University of Arkansas for Medical Sciences Graduate School, also recognized Koeppe during Thursday's meeting. He and Koeppe served together for more than a decade.

McGehee said Arkansas is one of only two states that uses all of its tobacco settlement money for heath inititatives and healthcare research. Sui said the university will continue to use ABI funds to make new strategetic investments in biosciences research.

Link:
Koeppe Recognized for Service as ABI Institutional Director at University of Arkansas - University of Arkansas Newswire

Gabriela K. Popescu, professor of biochemistry in the Jacobs School of Medicine and Biomedical Sciences at UB, has been elected chair of the Council of Faculty and Academic Societies (CFAS) of the Association of American Medical Colleges (AAMC).

Popescu, a UB faculty member since 2006 and a UB alumna, began her two-year term as CFAS chair on Nov. 13 and will serve until Nov. 9, 2021, when she will become immediate past chair. As CFAS chair, she will serve as a member of the AAMCs board of directors until November 2021.

The AAMC represents the nations medical schools and teaching hospitals, and is dedicated to transforming health care through innovative medical education, cutting-edge patient care and groundbreaking medical research.

I am honored to step into this new role, Popescu says.

This year, she plans to engage and lead the CFAS Administrative Board in an overall evaluation of current activities, to identify areas of success and to find ways to more effectively serve as a voice for the faculty members the group represents.

CFAS formed in 2013 at the request of faculty who had formerly been active in the AAMCs Council of Academic Societies, with the goal of more directly engaging and representing faculty views and issues, and voicing them to the AAMC to help shape the development and implementation of its programs and policies.

As the largest of the AAMC councils, CFAS represents more than 173,000 full-time faculty with 350 faculty members, two representatives from each AAMC member school and society.

Popescu initially served on the administrative board, representing the Jacobs School. In 2017, she was named chair-elect and her primary responsibility was to chair the committee that organizes the annual CFAS spring meeting.

Last spring, she and CFAS colleagues organized what she calls a tremendously effective plenary session on sexual harassment in academic medicine and one of a few pioneering sessions held at national meetings on the subject. The session included opportunities for participants to learn and practice new skills designed to disrupt unconscious bias and to foster a more inclusive climate for women.

As CFAS chair for the next two years, she says, it will be important to continue to chisel the identity of this relatively new council, to engage and empower faculty representatives to speak loudly and effectively to the most critical issues facing academic medicine, and to foster a culture of inclusivity and appreciation.

Popescu believes that her experiences as a bench scientist, as a woman in academic medicine and as an immigrant serve her well in this leadership position.

Specifically, I feel that at this particular juncture, when the gender composition of our student body for the first time in history matches that of our nations population, it is important to commit ourselves to advancing and achieving equity along the entire career span of scientists and physicians, and across the spectrum of disciplines and specialties, she says.

Popescu points out that as a bench scientist, she is a representative of what is arguably the smallest of the three traditional tracks in academic medicine, the others being educators and clinicians.

Scientists here in the Jacobs School, like many others in academic medicine, have felt the specter of reduced National Institutes of Health funding and budgetary cuts for research amid talk of the high cost that basic research imposes on medical schools, she says.

My CFAS colleagues have mobilized under this threat and have been instrumental in demonstrating the value that science brings to the mission of medical schools, she continues. With this evidence from the trenches, the AAMC partnered with many others to make a successful case for the profitable investment that scientific discoveries represent for medicine. Today, bipartisan legislatures support predictable and sustainable funding for the NIH, and many scientists at the Jacobs School and across the country receive federal funds to push the boundaries of knowledge.

Popescu currently directs research funded by three NIH awards totaling more than $3.5 million. She has invested much of her career studying afamily of brain receptors called NMDA (N-methyl-D-aspartate) receptors that are critical to learning and memory. Her research on these receptors may lead to more effective strategies to treat a range of neurological and neurodegenerative conditions, from stroke, chronic pain and addiction to disorders such as schizophrenia and epilepsy.

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Popescu works to empower faculty, foster inclusivity as chair of national group - UB Now: News and views for UB faculty and staff - University at...

Scientists researching a key aspect of biochemistry in living creatures have been taking a very close look at the tiny Caenorhabditis elegans roundworm. Their latest results show that when these nematodes get put under more biochemical stress early in their lives, they somehow tend to live longer.

This type of stress, called oxidative stress - an imbalance of oxygen-containing molecules that can result in cellular and tissue damage - seems to better prepare the worms for the strains of later life, along the same lines as the old adage that whatever doesn't kill you, makes you stronger.

You might think that worm lifespans have no bearing on human life. And surely, until we have loads more research done in this field, it would be a big leap to say the same principles of prolonging one's lifespan might hold true for human beings.

But there's good reason to put C. elegans through the paces. This model organism has proven immensely helpful for researchers trying to better understand key biological functions present in worm and human alike - and oxidative stress is one such function.

The little wriggly creatures are known to have significant variations in their lifespan even when the whole population is genetically identical and grows up in the exact same conditions. So the team went looking for other factors that affect C. elegans' longevity.

"The general idea that early life events have such profound, positive effects later in life is truly fascinating," says biochemist Ursula Jakob from the University of Michigan.

Jakob and her colleagues sorted thousands of C. elegans larvae based on the oxidative stress levels they experienced during development this stress arises when cells produce more oxidants and free radicals than they can handle. It's a normal part of the ageing process, but it's also triggered by exercise and a limited food supply.

One way to measure this stress is by the levels of reactive oxygen species (ROS) molecules an organism produces - simply put, this measurement indicates the biochemical stress an organism is under. In the case of these roundworms, the more ROS were produced during development, the longer their lifespans turned out to be.

(University of Michigan)

To explain how this effect of ROS might come about, the researchers went looking for changes in the worms' genetic regulation, specifically those genes that are known to be involved in dealing with oxidative stress.

While doing so, they detected a key difference - the nematodes exposed to more ROS during development appeared to have undergone an epigenetic change (a gene expression switch that can happen due to environmental influences) thatincreased the oxidative stress resistance of their body's cells.

There are still a lot of questions to answer, but the researchers think their results identify one of the stochastic or random influences on the lifespan of organisms; it's something that has been hypothesised in the field of the genetics of ageing. And down the line, it may turn out to be relevant for ageing humans, too.

"This study provides a foundation for future work in mammals, in which very early and transient metabolic events in life seem to have equally profound impacts on lifespan," the researchers conclude.

The study has been published in Nature.

Continue reading here:
Fascinating Study Finds That Stressed Out Baby Worms Tend to Live Longer - ScienceAlert

Global Bench-top Veterinary Biochemistry Analyzers Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025  Industry News Info

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Global Bench-top Veterinary Biochemistry Analyzers Market 2019 by Manufacturers, Regions, Type and Application, Forecast to 2025 - Industry News Info

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Methylene Succinic Acid Market is Expected to Thrive at Impressive CAGR by 2024 & Top key Players are Itaconix Corporation, Qingdao Langyatai...

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Global Biochemistry Analyzers Market Key players and Growth Analysis Outlook up to 2019 to 2028 - Tech News Today

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Repot Scope:

Global C-Reactive Protein Test Market Segmentation By Type and Application:

Global C-Reactive Protein Test Market Segmentation By Type

Type 1Type 2Type 3

Global C-Reactive Protein Test Market Segmentation By Application:

Application 1Application 2Application 3

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Providing a thorough outline of the competitive and regional spheres of the C-Reactive Protein Test Market:

An important evaluation of the competitive landscape of this business is provided in the report.

Crucial data related to the Market share accumulated by each company along with facts pertaining to the sales area have been provided in the report.

The study offers a thorough assessment of the products manufactured by the firms, specifications, including their application frame of reference.

Information pertaining a basic outline, profit margins, price prototypes etc. of the companies participating in the C-Reactive Protein Test

Details related to every regions Market share along with the growth opportunities for each region is inculcated in the report.

The projected growth rate which every region is expected to register over the predicted time period is mentioned in the study.

Table Of Content

Chapter 1 :Definition, Specifications and Classification of C-Reactive Protein Test , Applications of C-Reactive Protein Test , Market Segment by Regions;

Chapter 2 :Manufacturing Cost Structure, Raw Material and Suppliers, Manufacturing Process, Industry Chain Structure;

Chapter 3 :Technical Data and Manufacturing Plants Analysis of C-Reactive Protein Test , Capacity and Commercial Production Date, Manufacturing Plants Distribution, R&D Status and Technology Source, Raw Materials Sources Analysis;

Chapter 4 :Overall Market Analysis, Capacity Analysis (Company Segment), Sales Analysis (Company Segment), Sales Price Analysis (Company Segment);

Chapter 5-6: Regional Market Analysis that includes North America, Europe, Asia-Pacific, South America, Middle East & Africa, C-Reactive Protein Test Segment Market Analysis (by Type);

Chapter 7-8 :The C-Reactive Protein Test Segment Market Analysis (by Application) Major Manufacturers Analysis of C-Reactive Protein Test ;

Chapter 9 :Market Trend Analysis, Regional Market Trend, Market Trend by Product Type, Market Trend by Application;

Chapter 10 :Regional Marketing Type Analysis, International Trade Type Analysis, Supply Chain Analysis;

Chapter 11 :The Consumers Analysis of Global C-Reactive Protein Test ;

Chapter 1 2 : C-Reactive Protein Test sales channel, distributors, traders, dealers, Research Findings and Conclusion, appendix and data source.,

Chapter 13,14 & 15 : C-Reactive Protein Test Research Findings and Conclusion, Appendix, methodology and data source;

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Contact: Global Marketers.Biz

Mr. Alex White Email: [emailprotected]

Phone number: +1(617)2753012

Website: https://www.globalmarketers.biz/

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Global C-Reactive Protein Test Market Outlook to 2026 ORTHO CLINICAL DIAGNOSTICS(J&J), Leadman Biochemistry, BioSino, KEHUA GROUP, ABBOTT -...