Category Archives: Biochemistry

Seven to receive 2020 Alumni Awards – News – Illinois State University News

David DeMarini 72, M.S. 74, Ph.D. 80, accepts the 2019 Distinguished Alumni Award.

Each yearIllinois State Universitys Alumni Association recognizes alumni for their outstanding contributions to their fields, their impact on society, and their passion for Illinois State through the Alumni Awards program. This year seven individuals will be honored at the Annual Awards Dinner:

Distinguished Alumni AwardJay D. Bergman 70CEO and chairman, Petco Petroleum Corp.Major/College: Business administration, College of Business

Alumni Achievement AwardDaniel Wagner 89, M.S. 94Senior vice president of government relations, Inland Real Estate GroupMajor/College: Political science, College of Arts and Science

Senator John W. Maitland Jr. Commitment to Education AwardDamian K. GregoryFounder and executive director, Gridiron Group

E. Burton Mercier Alumni Service AwardBeverly Grimes 60Retired nurseMajor/College: Nursing, Mennonite College of Nursing

Outstanding Young Alumni AwardPaul DeJong 15Shortstop, St. Louis CardinalsMajor/College: Biochemistry, College of Arts and Science

Jenna Goldsmith 08, M.S. 10Instructor of Writing, Oregon State University-CascadesMajor/College: English, College of Arts and Science

Griffin Hammond 07, M.S. 09Documentary Filmmaker, Recount MediaMajor/College: Television/Communication, College of Arts and Science

Nominations are also being sought for the 2021 Alumni Awards. The deadline to submit is May 31, 2020.

A quick summary how to recognize outstanding alumni.

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Seven to receive 2020 Alumni Awards - News - Illinois State University News

To the stars and beyond: A hundred years of Isaac Asimov – Hindustan Times

In a completely unscientific survey I conducted for the express purpose of writing this article, I sent a WhatsApp message to many of my (what I hoped were) sci-fi reading friends asking what they thought Asimovs greatest work (or their favourite Asimov work) was. The answers did not surprise me; there was absolutely no consensus. Everyone who had read Asimov had a different answer. Bicentennial Man and End of Eternity FTW! replied one. Some would say the Robot stories, but Foundation is more in-depth, answered another. Robot Dreams, said a third; his short stories definitelyespecially the AI ones, pinged a fourth; Nightfall. No questions there! said a fifth with complete confidenceand so on.

Of course, there was also one who said whos Asimov? Horrified, I explained that he was an acclaimed writer whose work had been made into several movies. Havent you seen I, Robot? I asked. Is that the one with Rajinikanth? came the tentative reply.

Message received. Asimov isnt everyones cup of tea.

But for those of us who revel in the scientific accuracy of fantastic worlds, in the possibility of reimagining the mundane into never-impossible futures, and found ways of thinking about the Big Questions of life through the stories of Multivac and lands where stars were only seen once in a thousand years, Isaac Asimov is a prophet (peace be upon his name).

A Russian immigrant in the USA in the 1930s, a professor of biochemistry, a war veteran, and a writer of popular science books, Isaac Asimov whose birth centenary it was on 02 January was also, possibly, the most successful science fiction writer of his generation.

His mind-bending stories of inter-stellar travel, other worlds, strange encounters, and sentient machines have never stopped fascinating readers since he first put finger to typewriter. One of the most prolific of writers, he has authored more than 500 books, edited several volumes, and all of this while also being a professor of biochemistry.

Born in a village called Petrovichi in Smolensk, Russia somewhere between October 1919 and January 1920, Isaac Asimov decided to celebrate his birthday on 02 January. He wrote in In Memory Yet Green, It could not have been later than that... There is, however, no way of finding out. My parents were always uncertain and it really doesnt matter. I celebrate January 2, 1920, so let it be.

The Asimovs emigrated to the USA in 1922, and after struggling for three years, managed to save enough money to open a small candy store in New York. It was there that a young Isaac discovered science fiction in the form of magazines lying around in the store and also discovered the incomparable joy of reading and getting lost in the pages of a good book.

Isaac Asimov discovered he was a storyteller in school, and soon even before he had turned 12 was already trying his hand at writing them. He also wrote a detailed daily journal, complete with baseball scores, and had a dedicated following as a teller of tales he had read in magazines and books. But before he ever wrote science fiction, as a teenager, he had first tried his hand at fantasy.

In Its Been a Good Life a compilation of Asimovs diary entries, personal communications, and a condensation of his earlier autobiographies he writes about the first piece of fiction he ever attempted to write on the used typewriter his father had bought him: (it was a story of) a group of men wandering on some quest through a universe in which there were elves, dwarves, and wizards, and in which magic worked.

This was in the year 1935. Asimov was 15, and JRR Tolkiens The Hobbit wasnt published till 1937 (The Lord of Rings trilogy, which pretty much set the template for fantasy fiction for the next several decades, would only be published twenty years later between July 1954 and October 1955). It was as though I had some premonition of JRR Tolkiens Lord of The Rings, writes Asimov. But for better or worse, it didnt stick.

By the mid-1930s, Asimov was an avowed sci-fi fan, writing letters to science fiction magazines and even joining fab clubs. And by 1938, as an undergraduate chemistry major at Columbia University, he had written his first complete science fiction story and went to the New York offices of the Astounding Science Fiction magazine to meet the editor and submit it for publication. The Editor John Campbell, who is credited with having found and nurtured an entire generation of science fiction writers, and went on to become Asimovs trusted friend and editor for many years to come rejected the piece, with a cordial letter that explained to the young Asimov why the story didnt work and how he could get better. It would take nine more rejections before Asimov was finally published in another magazine called Amazing Stories.

For a writer so dedicated to his craft and one who wrote as much as he did, it took Asimov another twenty years to be able to earn enough to live off writing full time. In the meanwhile, he finished his Bachelor of Science degree, spent three years as a civilian chemist in World War II in Philadelphia, returned to New York and earned his doctorate in chemistry, and got a job as professor of biochemistry in Boston.

Till then and after, he wrote some of science fictions best loved stories. Stories of 200 year old robots who wanted to be human (The Bicentennial Man); of elections in an age where computers could predict the mood of the nation with a sample size of one (Franchise); of super computers who had all the knowledge of the world, and couldnt yet answer one important question (The Last Question), and a history of a future in which a great civilisation came to an end (Foundation)

But he was more than just a teller of made up stories. He was really invested in the science he wrote about, and the great pains he took to keep the science realistic in his stories is matched only by the pleasure he took in the research of it all. The simple evidence of how deeply he cared about the science of his stories is in the number of nonfiction books he wrote. He was as proud of being a science writer as he was of being a science fiction writer. Having written on subjects as varied as nuclear physics and human biology; Asimov the polymath is the poster child of multi-disciplinarity and academia as at ease in the hard sciences as in sociology and history; as eager to learn and read when he became a full professor as he was as a teenager; and able to write in a clear and concise manner in fiction and science.

An atheist all his life, Asimov was a member of the humanist movement, and believed that human beings are responsible for the progressive advancement of society, and must step up and alleviate the ills of society themselves, instead of depending on supernatural forces. He even went so far as to sign the Humanist Manifesto in 1970. His two volume Asimovs Guide to the Bible is also written from a strictly humanist point of view.

It is a vision reflected in his stories, in his hopes for possible futures. In 1984 35 years after George Orwells grim book of that name was published Asimov was asked by the Toronto Star to predict what the world might look like 35 years from then (in 2019), and he managed to get quite a bit right. Even though we havent come to a point where we can live under the faint semblance of a world government by co-operation and we havent shifted polluting industries in a wholesale manner to space; he did foresee the human races increasing reliance on computers and predicted that mobile computerised objects would penetrate the home. He also predicted that there would have to be a vast change in the nature of education because wed have to learn to live in an increasingly high tech world.

Asimov, above all, was an optimist someone who was sure that the inherent good in enough members of the human race would outrun the evil forces and keep humans going for millennia to come. Oh the robots we would build! And the galaxies we would colonise! What adventures we would have! It is a world view that recognises the challenges of war and natural disasters and discrimination; but it is filled with hope for a better future, a fantastic future, a kinder future.

Isaac Asimov was possibly the most successful science fiction writer of his time.(Getty Images)

Little Known Facts About Isaac Asimov1. When Isaac Asimov was about two years old, 17 children in his village, including Isaac, contracted double pneumonia a disease in which both lungs become inflamed, making it near impossible to breathe. All but Isaac died. He credits his survival to his mother, who after the doctor had given up on him, held baby Isaac in her arms without ever letting go until he was better.

2. Though he wrote extensively about interstellar travel, Asimov was afraid of flying, and almost never took flights.

3. Asimov was fond of music and thought of Tchaikovsky as music that makes me feel happy and Beethoven as music that makes me feel awed.

4. He wrote more than science and science fiction! Asimovs Guide To The Bible was written in two volumes in 1968 and 1969. And in 1970, he wrote Asimovs Guide To Shakespeare. He organised the plays not as tragedies, comedies, and histories (as is usually done) but by region Greek, Roman, Italian, English. Other than writing his autobiographies, Asimovs Guide To Shakespeare was according to him the most pleasant work Ive ever done.

5. Paul McCartney, in 1974, asked Asimov if he would write a screenplay for a science fictional movie musical about a band whose members were being impersonated by aliens. Asimov wrote it, but it was never made (speculation is that it had been rejected because Asimov neglected to use the scraps of dialogue that McCartney had suggested).

6. Apart from his own (what he called legitimate) PhD, Asimov was awarded 14 honorary doctorates in his lifetime.

7. When Asimov had a triple bypass surgery in 1983, he contracted HIV from a bad blood transfusion. In 1990, Asimov and his wife Janet Jeppson Asimov found out about it but they did not go public with this information on the advice of his doctors. It was not revealed even when he died in 1992 of heart and kidney failure caused by AIDS. The truth came to light in 2002, when Janet revealed it in the epilogue to Its Been A Good Life.

8. In September 1983, Asimov met Indira Gandhi, when she was in New York City to attend the UN General Assembly. She was a gracious and intelligent woman, he wrote about the meeting.

9. A fan of Sherlock Holmes, Asimov was a member of the official fan club The Baker Street Irregulars; and even wrote a song (to be sung to the tune of Danny Boy) in praise of the detective for an annual dinner of the club. The first few lines were: Oh, Sherlock Holmes, the Baker Street Irregulars/ Are Gathered here to honour you today,/ For in their hearts you glitter like a thousand stars,/And like the stars, youll never fade away.

The Laws Of RoboticsOne of Asimovs most memorable contributions to the world are his Three Laws of Robotics. While scientists and others have written their own laws since, Asimovs were the first, most popular, and remain at the heart of all other laws of robotics. They have also formed the bedrock of much of sci-fi involving robots. Many writers have written stories, simply assuming the laws as fact.The Laws as Asimov wrote them:1. A robot may not injure a human being or, through inaction, allow a human being to come to harm.

2. A robot must obey the orders given it by human beings except where such orders would conflict with the first law.

3. A robot must protect its own existence as long as such protection does not conflict with the first or second laws.

Asimov credits his friend and publisher John Campbell with having come up with them.

It was at a meeting between Asimov and Campbell where Campbell was actually rejecting one of Asimovs stories that the idea for the laws emerged. Asimov was pitching a story about a robot that had become capable of reading minds due to a minor mistake on the assembly line.

And as they talked of the complications that robot telepathy might present, Campbell said, Look, Asimov, in working this out, you have to realize that there are three rules that robots have to follow. In the first place, they cant do any harm to human beings; in the second place, they have to obey orders without doing harm; in the third, they have to protect themselves, without doing harm or proving disobedient. Well ...

The Writers Personal FavouritesIn 1968, Asimovs story Nightfall was voted the best science fiction short story ever written, by the Science Fiction Writers of America, and many think that honour still holds.

But what were Asimovs favourites from among his own work?

Helpfully, he has answered the question himself. His own three favourite short stories were, in descending order:

(1) The Last Question

(2) The Bicentennial Man

(3) The Ugly Little Boy

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To the stars and beyond: A hundred years of Isaac Asimov - Hindustan Times

How Inflammation Can Lead to Depression – Psychology Today

When we think of things like depression, the role of inflammation seems secondary to, perhaps, social circumstances that cause sadness and trauma, or even ourgenetics, which is a continuous field of study in mental health. Inflammation in brain and spinal cord tissue (also known as headaches and backaches) can usually be lessened by swallowing a Tylenol or two. But researchers in Georgia and South Carolina were recently awarded grants from the National Institute of Mental Health (NIMH) to study the biochemistry that contributes to inflammation.

"Everything has a price. The price, however, isn't always money." -Ahmed Mostafa

Source: Wikimedia Commons

Why?

It goes back to swallowing a Tylenol to make your pain dissipatein other words, your biochemistry. In order to better understand our biochemistry and why Tylenol and other drugs are effective, we have to understand something called the complement system or the complement cascade. The complement system is part of a humans immune system.

Our immune system provides checks and balances throughout the body to keep us healthy. The complement system is made up of proteins derived from the liver. If your liver isnt healthy, theres a good chance you may be unhealthy in other areas as wellincluding your mental health.

The complement system was named by Paul Ehrlich (1854-1915). Ehrlich won a Nobel Prize for his contributions in immunology; he discovered the cure for syphilis, and in so doing, coined the term chemotherapy. Chemotherapy basically means using chemistry to treat diseasethough today, people use the phrase almost exclusively for the treatment of cancer.

When a human gets an infectionwhich can include something like the common cold orfluone of the first responses by the immune system is inflammation. Inflammation is a physical barrier, meant to help contain the infection in order to help promote healing. But researchers at the Medical College of Georgia at Augusta University have found that chronic stress actually causes inflammation in the brainin the same way that cold germs cause inflammation in our throat and nasal passages. Inflammation of the brain essentially destroys the connections between neurons, causing depression.

Monocytes are white blood cells.Monocytes circulate throughout our bodies during periods of stress as a line of defense. But it is the microglia or the immune cells in the brainthat may be delivering excess C3, a small protein from the complement system that causes continuous inflammation in the brain, which then contributes to depression.

Researchers at the Medical University of South Carolina College of Medicine are collaborating with Georgia researchers because their lab synthesizes something called complement inhibitors, or drugs that block C3 activation.

Though interferon-alpha is a drug used to treat cancer, its also a naturally-occurring protein produced by our bodies to stimulate the immune system in order to stop viral infections and the development of melanoma (skin cancer)a very useful aspect to our biochemistry. The problem comes in with prolonged use of the synthesized version. Patients treated with interferon-alpha for long periods of time had depression and other mental health issues.[i] Its interesting to note that when overused as a synthesized drug, the very protein our bodies create on their own works against us.

The theory is that increases in interferon-alphawhether through chronic stress or something like the treatment of canceractivatethe microglia, the immune cells in the brain. Activating the microglia ups the production of the C3 protein, which in turn not only damages communication between our neurons but outright destroys the connections between them. When our neurons cant communicate, we dont think properly. When we cant think properly, we cant act properly.

As we move into 2020, its important to remember that keeping ourselves in stressful environmentswhether at home or through a jobis not just causing situational depression (or temporary depression that goes away when the difficulty does), it mayactually be destroying brain function. The more we understand about how our bodies work, the healthier our minds will be, too.

In the new year, its of the utmost importance to remove yourself from anyrelationship that is causing chronic stress. Think of people who abuse you as not just abusers you can walk away from, but individuals who are causing you, your body, and your mind irreparable harm that can and will permanently affect both your physical and mental health.

No person or situation is worth injuring your life. Start fresh in 2020. If you have a difficult relationship, begin regular counseling sessions so you can at least have less stress as you work toward financial independence, increasing your ability to leave the toxicity behind. If your partner isnt amenable to counseling, you can always go to talk therapy sessions on your own.

Protecting your brain from the effects of chronic stress protects every aspect of your life. The year 2020 is all about living longer and stronger. That starts the moment you begin believing in yourself.

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How Inflammation Can Lead to Depression - Psychology Today

OSU scientists replace mice genes to study vitamin Ds effects on infections – The Register-Guard

By giving mice a human gene that helps fight infections, Oregon State University scientists have made a new model to show the impacts of vitamin D on staph infections.

Research from Oregon State University has shown a new model suggesting vitamin D treatment can dramatically reduce the quantity of disease-causing bacteria in skin wounds.

OSU scientist Adrian Gombart and his collaborators in the past have examined the vitamin's role in fighting infection, but in their new study mice were given a human gene that provides a barrier against infections and is promoted by the bioactive form of vitamin D.

Mice naturally have a similar gene, but vitamin D does not trigger it. The scientists replaced the mouse gene, called Camp, with the human gene, called CAMP, which gave the mice increased resistance to gut and staph infections, caused by the bacterium Staphylococcus aureus, when vitamin D was introduced.

Vitamin D3 regulates the expression of the CAMP, and Staphylococcus aureus is an important human pathogen that causes skin infections, Gombart said in a news release. With our mouse model, we showed that treating a skin wound infected with S. aureus with the bioactive form of vitamin D significantly reduced the number of bacteria in the wound.

Vitamin D, which is fat-soluble and present in very few foods, promotes calcium absorption in the gut and is needed for bone growth. Vitamin D, manufactured by the body when triggered by sunlight, is also important for cell growth, neuromuscular function, and reduction of inflammation.

The scientists believe their new model will be useful as research into vitamin D-induced expression of CAMP progresses, involving diseases caused by microorganisms and also conditions that are non-pathogenic, such as inflammatory bowel disease.

The finding, Gombart said, suggests vitamin D can be used to increase protection against infection by increasing CAMP levels. Those findings recently were published in the Journal of Steroid Biochemistry and Molecular Biology.

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OSU scientists replace mice genes to study vitamin Ds effects on infections - The Register-Guard

2020 Biochemistry Analyzers Market Insight ( Investment Analysis, Market Overview and Focus on Top Players) | By QYResearch – The Picayune Current

Los Angeles, United State,January 2020 :

The latest report up for sale by QY Research demonstrates that the global Biochemistry Analyzers market is likely to garner a great pace in the coming years. Analysts have scrutinized the market drivers, confinements, risks, and openings present in the overall market. The report shows course the market is expected to take in the coming years along with its estimations. The careful examination is aimed at understanding of the course of the market.

Global Biochemistry Analyzers Market: Segmentation

The global market for Biochemistry Analyzers is segmented on the basis of product, type, services, and technology. All of these segments have been studied individually. The detailed investigation allows assessment of the factors influencing the market. Experts have analyzed the nature of development, investments in research and development, changing consumption patterns, and growing number of applications. In addition, analysts have also evaluated the changing economics around the market that are likely affect its course.

Get PDF template of Biochemistry Analyzers market [emailprotected] https://www.qyresearch.com/sample-form/form/1122038/global-Biochemistry-Analyzers-market

The various contributors involved in the value chain of the product include manufacturers, suppliers, distributors, intermediaries, and customers. The key manufacturers in this market includeAbbottDanaherRoche DiagnosticsSiemens

By the product type, the market is primarily split intoSemi-AutomaticFully Automatic

By the end users/application, this report covers the following segmentsHospital and Diagnostic LaboratoriesHome Care, and AcademicResearch Institutes

What will the report include?

Market Dynamics: The report shares important information on influence factors, market drivers, challenges, opportunities, and market trends as part of market dynamics.

Global Market Forecast: Readers are provided with production and revenue forecasts for the global Biochemistry Analyzers market, production and consumption forecasts for regional markets, production, revenue, and price forecasts for the global Biochemistry Analyzers market by type, and consumption forecast for the global Biochemistry Analyzers market by application.

Regional Market Analysis: It could be divided into two different sections: one for regional production analysis and the other for regional consumption analysis. Here, the analysts share gross margin, price, revenue, production, CAGR, and other factors that indicate the growth of all regional markets studied in the report.

Market Competition: In this section, the report provides information on competitive situation and trends including merger and acquisition and expansion, market shares of top three or five players, and market concentration rate. Readers could also be provided with production, revenue, and average price shares by manufacturers.

Strategic Points Covered in TOC:

Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Biochemistry Analyzers market

Chapter 2: Evaluating the leading manufacturers of the global Biochemistry Analyzers market which consists of its revenue, sales, and price of the products

Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales

Chapter 4: Presenting global Biochemistry Analyzers market by regions, market share and with revenue and sales for the projected period

Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions

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2020 Biochemistry Analyzers Market Insight ( Investment Analysis, Market Overview and Focus on Top Players) | By QYResearch - The Picayune Current

How our phones became our whole lives in just 10 years, from a woman who resuscitates them – NBC News

When did you last put pictures in a photo album? When did you last drop off a roll of film at a drugstore, then flip through the prints an hour later? It was probably some time before the last decade given that, at the start of 2013, more than 50 percent of American adults had a smartphone for the first time, and now more than 80 percent of us do.

Since we wrapped our fingers around the first touch-screen smartphones a decade ago, the family photo album has all but ceased to exist. But even as we no longer make albums of them, we are even more obsessed with taking pictures. We spend hours transcribing our entire lives into digits inside memory chips on our phones, and maybe posting some small percentage of them online.

These photos are our lives now we can all remember every important moment in an entire year in just a few minutes by scrolling through our camera roll. If it was notable, we took a picture. For the first time ever, we can visualize an entire life, including somebody else's.

My job is to recover these pictures and videos when things go wrong sometimes very wrong. Each day, people from all over the world reach out to the iPad Rehab Microsolderings team of former stay-at-home moms (and one dad) after one of lifes most gut-wrenching moments. They are staring at a dead phone, usually a loved one's, and realizing that the data they thought or hoped was backing up, wasnt.

It is a beloved privilege to be trusted with the responsibility to recover these memories. We get to tell families every day Great news, we got the pictures back!

But what will become of these now-recovered pictures? Will they be printed, hung up and cherished, or will they rot on a USB stick never to be seen again, after the joy of the initial reunion fades? Few of us will ever really get around to loading those pictures onto the digital frame we always mean to buy. Our pictures tend to sit there on our individual phones, unseen, secure inside a tiny chip, because we are too busy spending our lives capturing newer pictures of sushi, birthday parties and sunsets you can almost see.

On a recent trip to New York City, I signed up for the sunset viewing at the top of the Rockefeller Center and, like everyone else, I took a picture. The picture I took, though, was a picture of all the people taking pictures. Some people there never did see the sun actually set they just saw the view of the sunset through their phones, held high above their heads.

At my kids' recent holiday concert, like many a parent, I quietly ignored the principals request to turn off our cellphones and just enjoy the concert. Instead, I took a picture and posted it on social media right in the middle of the concert; the caption read, I am filled with holiday joy that the six parents near me who are secretly videotaping the concert are all holding their phones in landscape mode.

It is possible we were better off when we were restricted to 24 carefully chosen shots on a tangible roll of film.

It's hard to imagine that this has all changed so much in 10 years, but it has. We suffer from a near-constant digital information overload; there is too much choice, and way too much noise. The sum of the knowledge of humanity is stuffed into our back pockets, as is access to nearly anything it can create. In the past, buying a new lawn chair would mean standing at a store and deciding between one with green woven canvas strips and one with blue. Today, it means scrolling through endless chair variations, struggling to distinguish fake reviews from genuine, and then being haunted by nagging ads stalking us everywhere we go online. Sometimes we simply give up.

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We are part of a grand experiment: Never before have human brains been constantly exposed to the ceaseless parade of stimulation that pours from devices in our pockets.

In order to be heard above the cacophony of the internet, even our news media is forced to shout increasingly polarizing viewpoints. To deal with the sheer volume of information, our brains seek to bundle and categorize awesome or terrible and slowly lose the ability to notice and appreciate nuance. There is no longer a middle.

Through our phones, we stare into the lights of Las Vegas when we first wake up, and just before we try to sleep. How does this affect the biochemistry of our brain? We dont know for sure, but studies are already suggesting the answer is not good.

A few weeks ago, I finally decided to give it all up ... well, for one night a week. Our family started an evening of digital respite, when we turn off our phones, tablets, computers and even the television. It is just as hard as it seems, and just as amazing.

Life unplugged feels dry and brittle at first. It is painful; I dread it each week. Im dismayed to realize that feels emotionally identical to quitting smoking.

The amount of extra time, though, is phenomenal. Did you know that you can go sledding, stop by the library, make dinner and memorize all five verses of "Good King Wenceslas" before 7:00 p.m. on a Tuesday? In the second week, I laid on the bed feeling like a disgrace to my generation. What did we do with our time growing up without phones and computers? I couldnt remember. That day I spent an hour just talking with my husband about not work and not kids. When was the last time we did that?

In the third week I found myself saying yes, out of boredom, to things to which Id normally Id say no. Can we make cookies? Yes. Can we make a gingerbread house? Yes. Do you want to go cross-country skiing with me? Yes. Will you read this book with me for two solid hours tonight? Yes. Will I remember these times more than a few gigabytes of buried digital memories? Definitely.

I taught them things: We explored how to navigate without Google maps, how to live without looking up a weather forecast. They are now wholly convinced that, yes, it is indeed impossible for a human hand to break an intact egg; they know that teeth can do a fine job of it. I learned incredible details about the fabric of my childrens lives that I miss when obsessed with photo-documenting every moment.

Our phones are amazing. But we rely on them too much. We are addicted.

And, beyond that, the idea that they are helping us keep an incredible record of our lives that will persist for generations has more than a few caveats. Yes, our great-great-grandchildren will be able to get to "know" us in a way that is unprecedented if we back up our data and find ways to pass down accessing it; I'm not sure my parents' eight-tracks or boxes of slides will be so useful to my kids.

But with the increasing complexity of mobile phone security and data encryption, the ability of people like me to recover these precious memories will become more and more limited without the support of the manufacturers. Back up your data and support the right to repair, or all those pictures you're taking to show the truth of your life to your kids one day won't be worth the silicon on which they're embedded. Plus, you have to have conversations with your family or your friends about what will happen to your phone, your pictures and your entire digital footprint when you die or else large corporations and planned obsolescence will make those decisions for you in your absence.

In the meantime, though: Put your phone down. Watch a sunset. Enjoy your kid's school play as it happens. Make some cookies that exist only in your shared memories.

More from our decade reflections project:

THINKing about 2010-2019: Where we started, how we grew and where we might go

A decade of Black Lives Matter gives us a new understanding of Black liberation

College in the U.S. is at a crossroads. Will it increase social mobility or class stratification?

The success of the 'me too' movement took a decade of work, not just a hashtag

The decade in LGBTQ: Pop culture visibility but stalled political progress

Egg freezing and IVF in the 2010s brought us the next phase in women's lib

How Netflix, Star Wars and Marvel redefined Hollywood and how we experience movies

Opioids, pot and criminal justice reform helped undermine this decade's War on Drugs

Climate change became a burning issue in the past decade, but also an opportunity

Taylor Swift, Beyonc, Rihanna, Gaga, Pink and Kesha cleared the way for women in the 2010s

Celebrities like Gwyneth Paltrow made the 2010s the decade of health and wellness misinformation

White Christian America ended in the 2010s

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How our phones became our whole lives in just 10 years, from a woman who resuscitates them - NBC News

How the fear of death affects our investment processes – MoneyWeek

Our investment impulses are driven by the knowledge that, one day, we will be dead.This article is taken from our FREE daily investment email Money Morning.

Every day, MoneyWeek's executive editor John Stepek and guest contributors explain how current economic and political developments are affecting the markets and your wealth, and give you pointers on how you can profit.

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This year, I published my first book. Its called The Sceptical Investor, and its about contrarian investing or, as Ive slightly cheekily rebranded it, sceptical investing.

My publisher, Harriman House, is offering a cracking deal on the book right now. You can get 40% off by ordering it here, and entering the code SCEPTIC40 at the check-out.

If youre not convinced by that fantastic value investment, let me share an extract with you in todays Money Morning its from Chapter 5, entitled You vs the crowd.

As with any complex system, you cant model the human mind perfectly. Were a morass of conflicting, shifting desires affected by changes in both our internal environment (our own biochemistry) and our interactions with our external environment (other people, the weather, whats on the telly).

But we dont need to go into complicated models of individual minds to get a good idea of how crowds work. There are just two key impulses to wrap your head around.

Theyre commonly described as greed and fear. But Im not so keen on those labels both have very negative connotations. I prefer to say we have an expansionary impulse and a contractionary one.

When you are in an expansionary mood, your focus is on growing your wealth, grabbing a bigger piece of the cake, empire-building. When you are in contractionary mode, you want to hunker down, build walls, protect what is yours.

These two impulses are in turn driven by one simple fact: the knowledge that, one day, you will be dead.

When evolutionary psychologists and behavioural economists talk about what drives our herding instincts, they often hark back to the days when we were dwelling in Stone Age tribes out on the African savannah, at constant risk of being picked off by lions, dying of dehydration, or nibbling on some poisonous vegetation.

The idea is that we are programmed to run with the crowd because its safer. But theres more to it than a simple evolutionary hangover. You really dont have to go back to the Stone Age to find unforgiving death lurking around every corner.

Vaccines and antibiotics only became widely available to most people (in developed countries at that) in the middle of the last century.

In 1924, four years before the discovery of penicillin, the 16-year-old son of one of the most powerful men in the world US president Calvin Coolidge died of septicaemia that resulted from a blister that developed on his toe while he was playing tennis in ill-fitting shoes.

Even today, and even in the most advanced societies, life is unpredictable and full of potentially lethal threats. And while all animals have a fight or flight instinct when faced with life- threatening situations, only humans (as far as we can tell) have a sufficiently evolved brain to bless us with an ever-present awareness of the inevitability of our own extinction.

This fear may not always be at the forefront of our minds, but its never far away.

What does any fundamentally rational being crave in such an environment? Its not happiness or contentment (although these may be desirable side effects).

Its security and certainty.

I want to keep myself and my loved ones safe, and I also want to know that after I am gone, the things that I value will persist (it doesnt matter that Ill be gone at that point what matters is how I feel about that now, while Im alive).

To do that, I need to be able to do two things. I need to get out there and explore and master my environment in order to take advantage of opportunities that could make my life better and my situation more secure (the expansionary impulse).

But I also need to be highly alert to danger and ready to raise my defences in response to threats to that security (the contractionary impulse).

So how do we navigate an uncertain world? How do we impose order on the chaos around us? Its simple. We look for elements that appear to be predictable we seek patterns.

We look for cause-and-effect rules that govern outcomes and can be used to influence them. If we know (or at least think we know) that x causes y, then we can increase our level of certainty in our world view.

Some rules are governed by natural phenomenon dont fall off cliffs; dont eat poisonous mushrooms. Some are instinctive (social animals such as humans and apes have been found to have an inherent sense of fairness, even though the world itself is clearly not naturally fair).

But many of the most important ones are social (such as learning the conventions for crossing a road or transacting with one another).

And the critical point is that we dont formulate these worldviews alone. They are passed down from our parents, and reinforced by our schools, friends, co-religionists and colleagues.

In fact, historian Yuval Noah Harari, in his recent bestseller Sapiens, argues that this ability to create and believe in epic, society-spanning shared world views from religions to legal systems to money itself (which ultimately derives its value from our belief in it, and the social structures that give everyone the confidence to rely upon it) is key to our spectacular success as a species.

You can call them stories, as Harari does, or you can call them social structures, or you can think of them as rules for a particularly complicated board game.

But however you describe them, they are all systems that human beings have invented to enable us to cooperate in a more mutually bene cial way and our brains are wired to be receptive to information presented like this.

Which unfortunately, can be a real handicap in the world of investment.

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How the fear of death affects our investment processes - MoneyWeek

Experts Reveal Beating Heart of Photosynthesis Can Help Us Meet Urgent Food Security Needs – SciTechDaily

Protein structure solved by study. Credit: University of Sheffield

Scientists have solved the structure of one of the key components of photosynthesis, a discovery that could lead to photosynthesis being redesigned to achieve higher yields and meet urgent food security needs.

The study, led by the University of Sheffield and published in the journal Nature, reveals the structure of cytochrome b6f the protein complex that significantly influences plant growth via photosynthesis.

Photosynthesis is the foundation of life on Earth providing the food, oxygen, and energy that sustains the biosphere and human civilization.

Using a high-resolution structural model, the team found that the protein complex provides the electrical connection between the two light-powered chlorophyll-proteins (Photosystems I and II) found in the plant cell chloroplast that convert sunlight into chemical energy.

Lorna Malone, the first author of the study and a Ph.D. student in the University of Sheffields Department of Molecular Biology and Biotechnology, said: Our study provides important new insights into how cytochrome b6f utilizes the electrical current passing through it to power up a proton battery. This stored energy can then be then used to make ATP, the energy currency of living cells. Ultimately this reaction provides the energy that plants need to turn carbon dioxide into the carbohydrates and biomass that sustain the global food chain.

The high-resolution structural model, determined using single-particle cryo-electron microscopy, reveals new details of the additional role of cytochrome b6f as a sensor to tune photosynthetic efficiency in response to ever-changing environmental conditions. This response mechanism protects the plant from damage during exposure to harsh conditions such as drought or excess light.

Dr. Matt Johnson, reader in Biochemistry at the University of Sheffield and one of the supervisors of the study added: Cytochrome b6f is the beating heart of photosynthesis which plays a crucial role in regulating photosynthetic efficiency.

Previous studies have shown that by manipulating the levels of this complex we can grow bigger and better plants. With the new insights we have obtained from our structure we can hope to rationally redesign photosynthesis in crop plants to achieve the higher yields we urgently need to sustain a projected global population of 9-10 billion by 2050.

###

Reference: Cryo-EM structure of the spinach cytochrome b6fcomplex at 3.6 resolution by Lorna A. Malone, Pu Qian, Guy E. Mayneord, Andrew Hitchcock, David A. Farmer, Rebecca F. Thompson, David J. K. Swainsbury, Neil A. Ranson, C. Neil Hunter and Matthew P. Johnson, 13 November 2019, Nature.DOI: 10.1038/s41586-019-1746-6

The research was conducted in collaboration with the Astbury Centre for Structural Molecular Biology at the University of Leeds.

Researchers now aim to establish how cytochrome b6f is controlled by a myriad of regulatory proteins and how these regulators affect the function of this complex.

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Fruitfly Drosophilia at the heart of global conference in Pune – Hindustan Times

Prachi Bari

PUNE: Scientists from across the world who use the common fruitfly Drosophila as a model organism to address basic and applied questions in life sciences, will be participating in the 5th Asia Pacific Drosophila Research Conference (APDRC5) and Indian Drosophila Research Conference here next week.

Two Nobel laureates, Eric Wieschaus and Michael Rosbash, renowned for their work in development biology and chronobiology respectively, will be among the 100 international and 330 Indian participants in this five-day conference. It is being organised for the first time in the country by the Indian Institute of Science Education and Research (IISER).

IISERs Professor (Biology) Sutirth Dey, who is using Drosophilia for research in Ecology and Evolution said this common fruitfly is one of the most widely-used model organism in the world for research in life sciences over the last 100 years.

Its genome is entirely sequenced and there is enormous information available about its biochemistry, physiology and behaviour. That is why it is one of the most preferred model organisms in Biology, said Dey.

He noted that IISER, Pune, has a strong focus on Drosophila research with five professors and 30 PhD scholars using this organism to answer questions in developmental biology (Prof LS Shashidhara), cell biology (Prof Richa Rikhy), gene regulation and immunity (Prof Girish Ratnaparkhi) and neurobiology (Prof Aurnab Ghose).

IISER scientist and head, research communications, Shanti Kalipatnapu said, some of the biggest names in neurobiology, cell biology, developmental biology and evolutionary biology will be attending the conference. Krishnaswamy Vijay Raghavan, principal scientific adviser to the Government of India, will be one of the nine plenary speakers at the event.

Held previously in Taipei, Seoul, Beijing and Osaka, one of the highlights of this conference is that we are explicitly encouraging undergraduates from various institutes of the world to participate, said Dey.

A total of 57 talks and 240 posters covering topics such as Gametogenesisand Stem Cells, Pattern formation, Morphogenesis and Mechanobiology, Hormones and Physiology, Cellular Neurobiology, Behavioural Neurobiology, Infection and Immunity and Ecology and Evolution, will be covered in the conference.

One pre-conference symposium called Signals from the gut will be held in collaboration with the city-based National Centre for Cell Sciences (NCCS) with 70 participants.

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The best health advice from 2019 – The Week

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Napping may boost your heart health. That's the finding of researchers in Switzerland, who tracked 3,462 healthy adults for five years. Those who dozed for five minutes to an hour once or twice a week were 48 percent less likely to suffer a heart attack, stroke, or heart failure than those who never snoozed in the daytime. Napping longer or more often didn't deliver any additional health benefits. Lead author Nadine Husler says it's still unclear how napping might influence heart health. "Our best guess," she says, "is that a daytime nap just releases stress from insufficient sleep."

Eating mushrooms could lower your chances of developing memory problems in later life. A study involving 663 Chinese men and women found that those who ate one or two 5-ounce portions of mushrooms a week had a 43 percent lower risk of developing mild cognitive impairment a precursor to Alzheimer's than participants who consumed less than one. Those who ate more than two portions had a 52 percent reduced risk. Lead author Lei Feng says the most likely explanation for this "dramatic effect" is that the fungi contain antioxidants that protect neurons from damage.

Having kids makes you happier once they've grown up and moved out. Previous research has shown that, earlier in life, people with children are less happy and more prone to depression than childless peers, partly because they get less sleep and experience more stress. But a study of 55,000 Europeans found that parents were more likely to be happier when they got older, provided their offspring had flown the nest. Researchers say grown kids can offer parents more social and emotional connection, as well as care and other support. "There is no simple answer on whether children bring happiness," says lead author Christoph Becker. "It depends on which stage of life your children are at."

Running just once a week could significantly cut your risk of a premature death. Researchers in Australia looked at 14 studies that tracked the health of some 230,000 people for up to 35 years. Those who did any running at all were 27 percent less likely to die early. Surprisingly, the runners who ran longer distances or at a faster pace didn't see their risk decline any further just 50 minutes of jogging a week was enough. "If you are physically inactive and don't have much time on your hands for exercise," says lead author Zeljko Pedisic, "running might just be the right activity for you."

NSAIDs such as aspirin and ibuprofen may help relieve depression. In an analysis of previous studies, researchers in China found that a daily dose of nonsteroidal anti-inflammatory drugs (NSAIDs) was 79 percent more effective than a placebo at eliminating depressive symptoms. Several studies have linked depression to brain and body inflammation, leading to speculation that an overactive immune system which can cause inflammation could be a factor. Alan Carson, who edited the study, says depression "may simply be the price we pay for having an immune system."

Northern Irish soil could have healing properties. Residents of the Boho Highlands have been using the alkaline dirt from a local churchyard as a folk remedy for 200 years. An analysis of this "sacred clay" revealed that it contains a previously unknown strain of Streptomyces bacterium that can halt the growth of four of the top six superbugs resistant to conventional antibiotics. Scientists believe such traditional medicines may prove to be a useful source of new antibiotics. "Some of these cures might have been perfectly effective," says co-author Gerry Quinn. The people "just didn't have any knowledge of the scientific principles or biochemistry behind them."

High-fiber foods can shrink your risk of dying early or developing a chronic condition. A scientific review commissioned by the World Health Organization noted that people who ate the most fiber found in fruit, vegetables, and whole-grain cereals, pasta, and bread were 15 to 30 percent less likely to die prematurely than those who ate the least. Heavy fiber consumers were also 16 to 24 percent less likely to suffer a stroke or develop heart disease, type 2 diabetes, or colorectal cancer. The optimal fiber intake was 25 to 29 grams a day; American adults consume an average of 15 grams.

Playing soccer may increase your risk of neurodegenerative disease. Researchers in Scotland compared the deaths of 7,676 male former pro soccer players with those of more than 23,000 people from the general population. The ex-players had a longer life expectancy overall, but a 3.5 times higher risk of dying from diseases such as Alzheimer's and Parkinson's. While soccer players don't endure the same kind of crashing tackles that can cause degenerative brain disease in football players, frequent heading of the ball can alter the makeup of the brain. "It is not just the 'big hits' resulting in symptomatic concussions that increase the risk of neurologic disorders later in life," says neurologist Robert Stern.

Aspirin could significantly raise the chance of dangerous bleeds in the gut and skull. A daily dose of the blood-thinning drug can help prevent heart attacks and strokes for those with existing cardiovascular issues. But a review by British scientists of 13 previous studies found that for people with no issues, the cons outweigh the pros. Overall, aspirin reduced the risk of cardiovascular problems by 11 percent but was linked to a 43 percent increase in significant bleeding events. Co-author Sean Lee Zheng says that before prescribing the drug, physicians should weigh "any small potential cardiovascular benefits [against] the real risk of severe bleeding."

Ultraprocessed foods can shorten your life. A French study found that every 10 percent increase in consumption of these foods such as chicken nuggets, potato chips, and ready-to-eat meals was linked to a 14 percent higher risk of early death. The researchers say some additives in ultraprocessed products are carcinogenic and that chemicals from packaging may leak into the foods. Co-author Mathilde Touvier recommends people "avoid these foods as much as they can."

Getting a tattoo can put toxic metal fragments in your body. German scientists examined 12 new steel tattoo needles with a high-powered microscope, both before and after use. They found that chromium and nickel particles break off during the tattooing process and become embedded in the skin. Those metals can travel through the body and build up in lymph nodes, potentially triggering an allergic reaction. Anyone thinking of getting inked, says lead author Ines Schreiver, should be aware they could be exposed to "impurities that might be allergenic or carcinogenic."

Vaping may damage blood vessels. Using MRI scans, University of Pennsylvania scientists monitored blood flow in 31 nonsmokers. After participants had several puffs on an e-cigarette without a flavor or nicotine, their blood flow was noticeably worse. Overall, vaping temporarily constricted arteries in the legs, heart, and brain by more than 30 percent. The researchers believe glycerol and propylene glycol, the core ingredients of vape fluid besides water, can irritate the lining of blood vessels. More than 2,400 people have been hospitalized over the past year for vaping-related lung illnesses, and at least 52 have died. Scientists suspect many had vaped illicit liquids containing THC the psychoactive compound in marijuana that had been cut with vitamin E acetate, a sticky oil that can cling to the lungs.

Also from The Week: The best things you didn't watch, read, and listen to in 2019

Doctors' coats are often contaminated with dangerous bacteria and other pathogens. A review of previous studies found that up to 16 percent of the garments tested positive for MRSA, and up to 42 percent for Gram-negative rods antibiotic-resistant bacteria that can cause skin and blood infections, sepsis, pneumonia, and other health issues. Researchers found that stethoscopes, phones, and digital tablets can also be contaminated with dangerous bacteria. Previous studies have found that most American physicians wash their coats less than once a week; up to 17 percent go more than a month between washes.

White meat may raise your cholesterol levels as much as red meat. Researchers put 113 adults on three rotating monthlong diets: one centered on lean cuts of beef, the second on lean cuts of chicken, and the third on plant proteins. Half the participants' diets irrespective of their main protein source were high in saturated fats, while half were low. Overall, white meat raised levels of LDL cholesterol, the so-called bad cholesterol that clogs arteries, just as much as red meat even when saturated fat levels were equal.

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